colforsin has been researched along with Insulinoma in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (9.09) | 18.7374 |
| 1990's | 32 (58.18) | 18.2507 |
| 2000's | 16 (29.09) | 29.6817 |
| 2010's | 2 (3.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akiyama, S; Aoki, T; Araki, O; Murakami, M; Ogiwara, T; Tsunekawa, K | 1 |
| Mizoguchi, A; Saito, T; Seino, S; Shibasaki, T; Sugawara, K | 1 |
| Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S | 1 |
| Albrecht, E; Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S | 1 |
| Chankiewitz, E; Csernus, VJ; Mühlbauer, E; Musshoff, U; Peschke, D; Peschke, E | 1 |
| Eliasson, L; Galvanovskis, J; MacDonald, PE; Obermüller, S; Rorsman, P; Vikman, J | 1 |
| Fujita, T; Kadowaki, T; Kimata-Hayashi, N; Sekine, N; Takano, K | 1 |
| Andon, NL; Bilakovics, JM; Ghosh, SS; Hanley, MR; Lowe, C; Pittner, R; Taylor, SW | 1 |
| Cristino, L; De Petrocellis, L; Di Marzo, V; Marini, P; Matias, I; Moriello, AS; Nigam, S; Starowicz, K | 1 |
| Mühlbauer, E; Peschke, E; Stumpf, I | 1 |
| Pozzan, T; Ullrich, S; Wollheim, CB | 1 |
| de Mazancourt, P; Goldsmith, PK; Weinstein, LS | 1 |
| McDermott, AM; Sharp, GW | 1 |
| Göke, B; Göke, R; McGregor, GP | 1 |
| Bokvist, K; Dissing, S; Frøkjaer-Jensen, J; Gromada, J; Renström, E; Rorsman, P; Wulff, BS | 1 |
| Jochum, C; Mayer, P; Pfeiffer, A; Schatz, H | 1 |
| Kojima, I; Miyazaki, J; Ogata, E; Sekine, N; Yamashita, N | 1 |
| Habener, JF; Holz, GG; Leech, CA | 1 |
| Fehmann, HC; Göke, B; Strowski, M | 1 |
| Bertherat, J; Epelbaum, J; Li, JY; Rauch, C; Sassolas, G; Schaison, G; Turpin, G | 1 |
| Becker, TC; BeltrandelRio, H; Cassidy, LE; Clark, S; Ferber, S; Hughes, SD; Johnson, JH; Newgard, CB; Noel, RJ | 1 |
| Brunner, HR; Grouzmann, E; Nicod, P; Thompson, N; Waeber, B; Waeber, G | 1 |
| Andell, S; Bartfai, T; Berthold, M; Bourne, J; Kask, K; Langel, U | 1 |
| Göke, B; Göke, R; Steffen, H | 1 |
| Fehmann, HC; Göke, B; Jiang, J; Pitt, D; Schweinfurth, J | 1 |
| Cobb, MH; Khoo, S | 1 |
| Cobb, MH; Dang, A; Do, V; Khoo, S; Schaefer, EM; Witt, S; Xu, S; Zhen, E | 1 |
| Bhatt, H; Easom, RA; Krueger, KA; Landt, M | 1 |
| Bokník, P; Knapp, J; Müller, FU; Neumann, J; Oetjen, E; Scheld, HH; Schmitz, W; Vahlensieck, U | 1 |
| Baroni, MG; Cavallo, MG; Mark, M; Monetini, L; Pozzilli, P; Stoehrer, B | 1 |
| Demuth, HU; Ehses, J; Hinke, SA; Kerridge, P; McIntosh, CH; Pauly, RP; Pederson, RA | 1 |
| Aust, G; Nguyen, TB; Scherbaum, WA; Seissler, J; Steinbrenner, H | 1 |
| Berggren, PO; Cooney, RV; Sjöholm, A | 1 |
| Bohrer, A; Hsu, FF; Ma, Z; Ramanadham, S; Turk, J; Wohltmann, M | 1 |
| Hescheler, J; Lenka, N; Su, J; Ullrich, S; Yu, H | 1 |
| Bloch, K; Vardi, P | 1 |
| Chepurny, OG; Holz, GG; Kang, G | 1 |
| Ma, Z; Ramanadham, S; Turk, J; Zhang, S | 1 |
| Abe, S; Ishizuka, J; Murakami, M; Satoh, Y; Shintani, S; Suzuki, K; Suzuki, S; Thompson, JC; Toyota, T | 1 |
| Hidaka, H; Li, G; Wollheim, CB | 1 |
| Asfari, M; Halban, PA; Janjic, D; Li, G; Meda, P; Wollheim, CB | 1 |
| Bataille, D; Demirpence, E; Gros, L; Jarrousse, C; Kervran, A | 1 |
| Fehmann, HC; Habener, JF | 1 |
| Bockaert, J; Carrette, J; Fehrentsz, JA; Hillaire-Buys, D; Landry, Y; Mousli, M; Rouot, B | 1 |
| Beinfeld, MC | 1 |
| Cooper, CW; Ishizuka, J; Murakami, M; Nickols, GA; Sumi, S; Thompson, JC; Townsend, CM | 1 |
| D'Ambra, R; Efrat, S; Fleischer, N; Starr, RG; Surana, M | 1 |
| Chiba, T; Fujita, T; Kadowaki, S; Morishita, T; Nakamura, A; Yamaguchi, A; Yamatani, T | 1 |
| Efrat, S; Fleischer, N; Surana, M | 1 |
| Nagamatsu, S; Nishi, M; Steiner, DF | 1 |
| Billestrup, N; Nielsen, JH; Petersen, ED | 1 |
| Danoff, A; Fleischer, N; Pasmantier, R; Schubart, UK | 1 |
| Chiba, T; Fujita, T; Inui, T; Kadowaki, S; Saito, Y; Yamaguchi, A; Yamatani, T | 1 |
| Gold, G; Grodsky, GM; Wieland, FT | 1 |
| Schonbrunn, A; Sullivan, SJ | 1 |
55 other study(ies) available for colforsin and Insulinoma
| Article | Year |
|---|---|
Glucagon-like peptide-1 stimulates type 3 iodothyronine deiodinase expression in a mouse insulinoma cell line.
Topics: Animals; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Exenatide; Gene Expression Regulation, Neoplastic; Glucagon-Like Peptide 1; Insulin-Secreting Cells; Insulinoma; Iodide Peroxidase; Mice; Pancreatic Neoplasms; Peptides; RNA, Messenger; Signal Transduction; Triiodothyronine; Triiodothyronine, Reverse; Venoms | 2014 |
Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Exocytosis; Glucose; Green Fluorescent Proteins; Immunoblotting; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Isoquinolines; Mice; Microscopy, Fluorescence; Microscopy, Immunoelectron; Mitochondrial Proteins; Okadaic Acid; Phosphorylation; Protein Transport; rab GTP-Binding Proteins; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Transfection | 2009 |
Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Colforsin; Gene Expression Regulation, Developmental; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Islets of Langerhans; Melatonin; Rats; Rats, Wistar | 2009 |
Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Colforsin; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Humans; Insulin-Secreting Cells; Insulinoma; Melatonin; Microscopy, Confocal; Pancreatic Neoplasms; Phosphorylation; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Time Factors; Transfection; Tryptamines | 2012 |
Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Biological Transport; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Melatonin; Pancreatic Neoplasms; Phosphodiesterase Inhibitors; Polymerase Chain Reaction; Probenecid; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Signal Transduction; Tryptamines; Tumor Cells, Cultured | 2002 |
Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.
Topics: Animals; Calcium; Calcium Channels; Cell Line, Tumor; Cell Membrane; Cell-Free System; Colforsin; Exocytosis; gamma-Aminobutyric Acid; Glucose; Insulinoma; Islets of Langerhans; Rats; Secretory Vesicles | 2005 |
Adrenomedullin inhibits insulin exocytosis via pertussis toxin-sensitive G protein-coupled mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Adrenomedullin; Calcium; Cell Line, Tumor; Colforsin; Exocytosis; Formazans; Glucose; GTP-Binding Proteins; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Membrane Potentials; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Phosphodiesterase Inhibitors; Tetrazolium Salts | 2006 |
Efficient high-throughput discovery of large peptidic hormones and biomarkers.
Topics: Amino Acid Sequence; Animals; Biomarkers, Tumor; Cell Line, Tumor; Colforsin; Computer Simulation; Culture Media, Conditioned; Drug Evaluation, Preclinical; Hormones; Insulinoma; Molecular Sequence Data; Pancreatic Neoplasms; Peptides; Proteomics; Rats | 2006 |
Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells.
Topics: Animals; Arachidonic Acids; Bombesin; Calcium; Cannabinoids; Capsaicin; Cell Line, Tumor; Colforsin; Dose-Response Relationship, Drug; Dronabinol; Enzyme Inhibitors; Estrenes; Insulinoma; Neuroprotective Agents; Neurotransmitter Agents; Pertussis Toxin; Phosphoinositide Phospholipase C; Pyrrolidinones; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sensory System Agents; Signal Transduction; Thapsigargin; TRPV Cation Channels | 2007 |
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line, Tumor; Colforsin; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide-Gated Cation Channels; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Guanylate Cyclase; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Melatonin; Pineal Gland; Rats; Rats, Wistar; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Tryptamines | 2008 |
Glyceraldehyde, but not cyclic AMP-stimulated insulin release is preceded by a rise in cytosolic free Ca2+.
Topics: Aminoquinolines; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Diterpenes; Fluorescent Dyes; Glyceraldehyde; Insulin; Insulinoma; Membrane Potentials; Pancreatic Neoplasms | 1984 |
Inhibition of adenylate cyclase activity by galanin in rat insulinoma cells is mediated by the G-protein Gi3.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Antibody Specificity; Base Sequence; Colforsin; Electrophoresis, Polyacrylamide Gel; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique; Galanin; GTP-Binding Proteins; Insulin; Insulin Secretion; Insulinoma; Molecular Sequence Data; Neuropeptides; Oligonucleotides, Antisense; Pancreatic Neoplasms; Peptides; Pertussis Toxin; Phosphates; Protein Biosynthesis; Rats; Receptors, Galanin; Receptors, Gastrointestinal Hormone; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Noradrenaline induces supersensitivity of adenylyl cyclase in NG108-15 and HT29-18 cells but not in the beta-cell RINm5F.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glioma; Humans; Hybrid Cells; Insulinoma; Kinetics; Neuroblastoma; Norepinephrine; Pancreatic Neoplasms; Tumor Cells, Cultured | 1995 |
Amylin alters the biological action of the incretin hormone GLP-1(7-36)amide.
Topics: Adenylyl Cyclases; Amyloid; Animals; Cell Line; Colforsin; Cyclic AMP; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Intolerance; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Models, Biological; Peptide Fragments; Peptides; Rats; Substance P | 1993 |
Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.
Topics: Animals; Calcium; Calcium Channels; Cell Line; Colforsin; Cyclic AMP; Cytoplasm; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Peptide Fragments; Ryanodine; Time Factors; Tumor Cells, Cultured | 1995 |
Okadaic acid indicates a major function for protein phosphatases in stimulus-response coupling of RINm5F rat insulinoma cells.
Topics: Animals; Bucladesine; Carbachol; Colforsin; Cyclic AMP; Ethers, Cyclic; Insulin; Insulinoma; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Tumor Cells, Cultured | 1994 |
Bimodal effect of transforming growth factor-beta on insulin secretion in MIN6 cells.
Topics: Animals; Colforsin; Dose-Response Relationship, Drug; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mice; Pancreatic Neoplasms; Tolbutamide; Transforming Growth Factor beta; Tumor Cells, Cultured | 1994 |
Pituitary adenylate cyclase-activating polypeptide induces the voltage-independent activation of inward membrane currents and elevation of intracellular calcium in HIT-T15 insulinoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Calcium; Calcium Channels; Colforsin; Electric Conductivity; Fura-2; Insulin; Insulin Secretion; Insulinoma; Lanthanum; Manganese; Membrane Potentials; Neuropeptides; Pancreatic Neoplasms; Pituitary Adenylate Cyclase-Activating Polypeptide; Sodium Channels; Spectrometry, Fluorescence; Tumor Cells, Cultured | 1995 |
Interaction of glucagon-like peptide-I (7-37) and somatostatin-14 on signal transduction and proinsulin gene expression in beta TC-1 cells.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Drug Interactions; Gene Expression; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Mice; Pancreatic Neoplasms; Peptides; Proinsulin; Receptors, Cell Surface; Receptors, Glucagon; Signal Transduction; Somatostatin; Tumor Cells, Cultured | 1994 |
Presence of somatostatin receptors negatively coupled to adenylate cyclase in ectopic growth hormone-releasing hormone- and alpha-subunit-secreting tumors from acromegalic patients responsive to octreotide.
Topics: Acromegaly; Adenylyl Cyclases; Adult; Carcinoid Tumor; Colforsin; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Immunohistochemistry; Insulinoma; Male; Multiple Endocrine Neoplasia Type 1; Octreotide; Pancreatic Neoplasms; Receptors, Somatostatin | 1994 |
GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.
Topics: 3-O-Methylglucose; Adenoviridae; Animals; Biological Transport; Cell Line; Colforsin; Gene Expression; Genetic Vectors; Glucokinase; Glucose; Glucose Transporter Type 2; Hexokinase; Humans; Insulin; Insulin Secretion; Insulinoma; Kinetics; Methylglucosides; Monosaccharide Transport Proteins; Pancreatic Neoplasms; Rats; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1994 |
Neuropeptide Y expression and regulation in a differentiated rat insulin-secreting cell line.
Topics: Adenylyl Cyclases; Animals; Cell Differentiation; Clonidine; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Neuropeptide Y; Pancreatic Neoplasms; Peptide Fragments; Protein Kinase C; Rats; Receptors, Neuropeptide Y; Tumor Cells, Cultured | 1993 |
Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells.
Topics: Animals; Binding Sites; Binding, Competitive; Bradykinin; Cell Membrane; Colforsin; Cyclic AMP; Galanin; Guanosine Triphosphate; Insulinoma; Ligands; Peptide Fragments; Pertussis Toxin; Protein Binding; Rats; Receptors, Galanin; Receptors, Gastrointestinal Hormone; Recombinant Fusion Proteins; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1995 |
The signal transduction of the glucagon-like peptide 1 receptor: fishing beyond the protein kinase level.
Topics: Colforsin; Electrophoresis, Gel, Two-Dimensional; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Isoelectric Focusing; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Precursors; Receptors, Glucagon; Signal Transduction; Tumor Cells, Cultured | 1996 |
Ligand-induced regulation of glucagon-like peptide-I receptor function and expression in insulin-secreting beta cells.
Topics: Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Protein Synthesis Inhibitors; Rats; Receptors, Glucagon; RNA, Messenger; Tumor Cells, Cultured | 1996 |
Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucose; Insulin; Insulin Secretion; Insulinoma; JNK Mitogen-Activated Protein Kinases; Kinetics; Mannoheptulose; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Tolbutamide; Tumor Cells, Cultured | 1997 |
Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism.
Topics: 3T3 Cells; Aluminum Compounds; Animals; Antibodies, Monoclonal; Astrocytes; Carbachol; Cell Line; CHO Cells; Colforsin; Cricetinae; Cricetulus; Embryo, Mammalian; Enzyme Activation; Enzyme Induction; Fluorides; Gene Expression Regulation, Enzymologic; Glucose; GTP-Binding Proteins; Insulin; Insulin Secretion; Insulinoma; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase Kinases; Pancreatic Neoplasms; PC12 Cells; Pheochromocytoma; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Receptors, Cell Surface; Recombinant Fusion Proteins; Signal Transduction; Transfection; Tumor Cells, Cultured | 1997 |
Calcium-stimulated phosphorylation of MAP-2 in pancreatic betaTC3-cells is mediated by Ca2+/calmodulin-dependent kinase II.
Topics: Adenylyl Cyclases; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Insulinoma; Islets of Langerhans; Isoquinolines; Kinetics; Microtubule-Associated Proteins; Pancreatic Neoplasms; Peptide Mapping; Phosphopeptides; Phosphorylation; Rats; Sulfonamides; Tumor Cells, Cultured | 1997 |
Identification and expression of a novel isoform of cAMP response element modulator in the human heart.
Topics: Animals; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP Response Element Modulator; Dimethyl Sulfoxide; DNA-Binding Proteins; Escherichia coli; Humans; Insulinoma; Myocardium; Pancreatic Neoplasms; Polymerase Chain Reaction; Recombinant Proteins; Repressor Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1998 |
Beta-cell gene expression and functional characterisation of the human insulinoma cell line CM.
Topics: Adenylyl Cyclases; Colforsin; Enzyme Activation; Gene Expression; Glucokinase; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 2; Humans; Insulin; Insulinoma; Islets of Langerhans; Models, Biological; Monosaccharide Transport Proteins; Stimulation, Chemical; Time Factors | 1999 |
Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide.
Topics: Analysis of Variance; Animals; Colforsin; Cyclic AMP; Gastric Inhibitory Polypeptide; Glucose; Insulin; Insulinoma; Islets of Langerhans; Male; Mice; Pancreatic Neoplasms; Perfusion; Rats; Rats, Wistar; Signal Transduction; Tumor Cells, Cultured | 2000 |
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoantigens; Colforsin; Cyclic AMP; Gene Expression Regulation; Glucagon; Glucose; Insulinoma; Islets of Langerhans; Kinetics; Membrane Proteins; Pancreatic Neoplasms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
gamma-tocopherol partially protects insulin-secreting cells against functional inhibition by nitric oxide.
Topics: Adenylyl Cyclases; Animals; Calcium; Calcium Channels; Carbachol; Cell Division; Cell Line; Cell Survival; Cholinergic Agonists; Colforsin; Cyclic GMP; Enzyme Inhibitors; Insulin; Insulin Secretion; Insulinoma; Interleukin-1; Islets of Langerhans; Models, Chemical; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Phorbol Esters; Protein Kinase C; Quinoxalines; Rats; Spermine; Type C Phospholipases; Vitamin E | 2000 |
Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2b
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Arachidonic Acid; Colforsin; Enzyme Inhibitors; Glucose; Group VI Phospholipases A2; Humans; Insulin; Insulin Secretion; Insulinoma; Kinetics; Mice; Naphthalenes; Pancreatic Neoplasms; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Pyrones; Rats; Recombinant Proteins; Signal Transduction; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Transfection; Tumor Cells, Cultured | 2001 |
The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Calcium; Colforsin; Electric Conductivity; Gene Expression Regulation; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Potassium Channel Blockers; Potassium Channels; Quaternary Ammonium Compounds; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetraethylammonium; Tolbutamide; Tumor Cells, Cultured | 2001 |
Therapeutic differentiation of tumor-derived insulin-producing cells selected for resistance to diabetogenic drugs.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Drug Resistance; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Pancreatic Neoplasms; Rats; Streptozocin; Tumor Cells, Cultured | 2000 |
cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells.
Topics: Animals; Caffeine; Calcium; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Exenatide; Gene Expression; Guanine Nucleotide Exchange Factors; Insulinoma; Ion Channel Gating; Islets of Langerhans; Pancreatic Neoplasms; Peptides; Phosphodiesterase Inhibitors; Rats; Ryanodine Receptor Calcium Release Channel; Transfection; Tumor Cells, Cultured; Venoms | 2001 |
Stimulation of insulin secretion and associated nuclear accumulation of iPLA(2)beta in INS-1 insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Nucleus; Colforsin; Cyclic AMP-Dependent Protein Kinases; Fluorescent Antibody Technique; Gene Expression; Glucose; Glycosylation; Group VI Phospholipases A2; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Phospholipases A; Phosphorylation; Rats; Signal Transduction; Transfection; Tumor Cells, Cultured | 2002 |
The effects of amylin on insulin secretion from Rin m5F cells and glycogen synthesis and lipogenesis in rat primary cultured hepatocytes.
Topics: Acetates; Amyloid; Animals; Arginine; Blood Glucose; Cell Line; Cells, Cultured; Colforsin; Cyclic AMP; DNA Replication; Glucose; Glyceraldehyde; Insulin; Insulin Secretion; Insulinoma; Islet Amyloid Polypeptide; Isoproterenol; Kinetics; Lipid Metabolism; Liver; Liver Glycogen; Male; Mice; Mice, Inbred Strains; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Thymidine | 1992 |
Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type Ca2+ channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Membrane Permeability; Colforsin; Cricetinae; Diphosphonates; Drug Synergism; Insulin; Insulin Secretion; Insulinoma; Ion Channel Gating; Isoquinolines; Manganese; Membrane Potentials; Mitochondria; Piperazines; Protein Kinase Inhibitors; Stimulation, Chemical; Tumor Cells, Cultured | 1992 |
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Colforsin; Insulin; Insulin Secretion; Insulinoma; Membrane Potentials; Mercaptoethanol; Pancreatic Neoplasms; Rats; Tumor Cells, Cultured | 1992 |
Characterization of binding sites for oxyntomodulin on a somatostatin-secreting cell line (RIN T3).
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Binding Sites; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucagon; Glucagon-Like Peptides; Insulinoma; Iodine Radioisotopes; Oxyntomodulin; Rats; Somatostatin; Tumor Cells, Cultured | 1992 |
Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells.
Topics: Adenylate Cyclase Toxin; Animals; Blotting, Northern; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Galanin; Gene Expression; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Mice; Models, Biological; Pancreatic Neoplasms; Peptide Fragments; Peptides; Pertussis Toxin; Proinsulin; RNA, Neoplasm; Transfection; Virulence Factors, Bordetella | 1992 |
Insulin releasing effects of mastoparan and amphiphilic substance P receptor antagonists on RINm5F insulinoma cells.
Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Animals; Cholera Toxin; Colforsin; Exocytosis; GTP-Binding Proteins; Insulin; Insulin Secretion; Insulinoma; Intercellular Signaling Peptides and Proteins; Molecular Sequence Data; Neoplasm Proteins; Pancreatic Neoplasms; Peptide Fragments; Peptides; Pertussis Toxin; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Stimulation, Chemical; Structure-Activity Relationship; Substance P; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wasp Venoms | 1992 |
CCK mRNA expression, pro-CCK processing, and regulated secretion of immunoreactive CCK peptides by rat insulinoma (RIN 5F) and mouse pituitary tumor (AtT-20) cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cholecystokinin; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Gene Expression; Insulinoma; Mice; Pancreatic Neoplasms; Pituitary Neoplasms; Protein Precursors; Rats; RNA, Messenger; Sincalide; Tumor Cells, Cultured | 1992 |
Role of extracellular magnesium in insulin secretion from rat insulinoma cells.
Topics: Animals; Calcium; Cell Line; Colforsin; Glyburide; Glyceraldehyde; Insulin; Insulin Secretion; Insulinoma; Kinetics; Magnesium; Pancreatic Neoplasms; Potassium Chloride; Rats; Tumor Cells, Cultured; Verapamil | 1992 |
Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Animals; Carbachol; Colforsin; Cyclic AMP; Drug Synergism; Glipizide; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Potassium; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Activation of PKC inhibits NaF-induced inositol phospholipid turnover in rat insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Protein Kinase C; Rats; Sodium Fluoride; Tumor Cells, Cultured | 1990 |
Glucose induces insulin gene transcription in a murine pancreatic beta-cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Nucleus; Colforsin; Cyclic AMP; Gallopamil; Genes; Glucose; Insulin; Insulinoma; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Promoter Regions, Genetic; Rats; Transcription, Genetic; Uridine Triphosphate | 1991 |
Biosynthesis of islet amyloid polypeptide. Elevated expression in mouse beta TC3 cells.
Topics: Amyloid; Animals; Blotting, Northern; Colforsin; Dexamethasone; Gene Expression; Insulin; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Mice; Molecular Weight; Protein Precursors; Protein Processing, Post-Translational; RNA, Messenger; Secretory Rate; Tumor Cells, Cultured | 1991 |
Effect of growth hormone and serum on the expression of the proto-oncogenes c-jun and c-fos in insulin producing cells.
Topics: Adenylyl Cyclases; Animals; Blood; Colforsin; Cycloheximide; DNA Probes; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation; Insulin; Insulinoma; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Somatomedins; Transcription Factors; Tumor Cells, Cultured | 1990 |
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Animals; Colforsin; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Glucagon; Insulinoma; Isoproterenol; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Pituitary Neoplasms; Potassium; Rats; Tetradecanoylphorbol Acetate | 1986 |
Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Carbachol; Colforsin; Cyclic AMP; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Phosphatidylinositols | 1987 |
Unregulated secretion of an exogenous glycotripeptide by rat islets and HIT cells.
Topics: Adenoma, Islet Cell; Animals; Cell Line; Colforsin; Egtazic Acid; Glucose; Glycopeptides; In Vitro Techniques; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Male; Pancreatic Neoplasms; Rats | 1988 |
Distribution of somatostatin receptors in RINm5F insulinoma cells.
Topics: Adenoma, Islet Cell; Animals; Cell Fractionation; Cell Membrane; Colforsin; Cytoplasmic Granules; Cytosol; Glucagon; Glyceraldehyde; Insulin; Insulin Secretion; Insulinoma; Iodine Radioisotopes; Kinetics; Leucine; Microsomes; Pancreatic Neoplasms; Rats; Receptors, Neurotransmitter; Receptors, Somatostatin; Somatostatin; Tumor Cells, Cultured | 1988 |