Page last updated: 2024-08-23

colforsin and Insulinoma

colforsin has been researched along with Insulinoma in 55 studies

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19905 (9.09)18.7374
1990's32 (58.18)18.2507
2000's16 (29.09)29.6817
2010's2 (3.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Akiyama, S; Aoki, T; Araki, O; Murakami, M; Ogiwara, T; Tsunekawa, K1
Mizoguchi, A; Saito, T; Seino, S; Shibasaki, T; Sugawara, K1
Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S1
Albrecht, E; Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S1
Chankiewitz, E; Csernus, VJ; Mühlbauer, E; Musshoff, U; Peschke, D; Peschke, E1
Eliasson, L; Galvanovskis, J; MacDonald, PE; Obermüller, S; Rorsman, P; Vikman, J1
Fujita, T; Kadowaki, T; Kimata-Hayashi, N; Sekine, N; Takano, K1
Andon, NL; Bilakovics, JM; Ghosh, SS; Hanley, MR; Lowe, C; Pittner, R; Taylor, SW1
Cristino, L; De Petrocellis, L; Di Marzo, V; Marini, P; Matias, I; Moriello, AS; Nigam, S; Starowicz, K1
Mühlbauer, E; Peschke, E; Stumpf, I1
Pozzan, T; Ullrich, S; Wollheim, CB1
de Mazancourt, P; Goldsmith, PK; Weinstein, LS1
McDermott, AM; Sharp, GW1
Göke, B; Göke, R; McGregor, GP1
Bokvist, K; Dissing, S; Frøkjaer-Jensen, J; Gromada, J; Renström, E; Rorsman, P; Wulff, BS1
Jochum, C; Mayer, P; Pfeiffer, A; Schatz, H1
Kojima, I; Miyazaki, J; Ogata, E; Sekine, N; Yamashita, N1
Habener, JF; Holz, GG; Leech, CA1
Fehmann, HC; Göke, B; Strowski, M1
Bertherat, J; Epelbaum, J; Li, JY; Rauch, C; Sassolas, G; Schaison, G; Turpin, G1
Becker, TC; BeltrandelRio, H; Cassidy, LE; Clark, S; Ferber, S; Hughes, SD; Johnson, JH; Newgard, CB; Noel, RJ1
Brunner, HR; Grouzmann, E; Nicod, P; Thompson, N; Waeber, B; Waeber, G1
Andell, S; Bartfai, T; Berthold, M; Bourne, J; Kask, K; Langel, U1
Göke, B; Göke, R; Steffen, H1
Fehmann, HC; Göke, B; Jiang, J; Pitt, D; Schweinfurth, J1
Cobb, MH; Khoo, S1
Cobb, MH; Dang, A; Do, V; Khoo, S; Schaefer, EM; Witt, S; Xu, S; Zhen, E1
Bhatt, H; Easom, RA; Krueger, KA; Landt, M1
Bokník, P; Knapp, J; Müller, FU; Neumann, J; Oetjen, E; Scheld, HH; Schmitz, W; Vahlensieck, U1
Baroni, MG; Cavallo, MG; Mark, M; Monetini, L; Pozzilli, P; Stoehrer, B1
Demuth, HU; Ehses, J; Hinke, SA; Kerridge, P; McIntosh, CH; Pauly, RP; Pederson, RA1
Aust, G; Nguyen, TB; Scherbaum, WA; Seissler, J; Steinbrenner, H1
Berggren, PO; Cooney, RV; Sjöholm, A1
Bohrer, A; Hsu, FF; Ma, Z; Ramanadham, S; Turk, J; Wohltmann, M1
Hescheler, J; Lenka, N; Su, J; Ullrich, S; Yu, H1
Bloch, K; Vardi, P1
Chepurny, OG; Holz, GG; Kang, G1
Ma, Z; Ramanadham, S; Turk, J; Zhang, S1
Abe, S; Ishizuka, J; Murakami, M; Satoh, Y; Shintani, S; Suzuki, K; Suzuki, S; Thompson, JC; Toyota, T1
Hidaka, H; Li, G; Wollheim, CB1
Asfari, M; Halban, PA; Janjic, D; Li, G; Meda, P; Wollheim, CB1
Bataille, D; Demirpence, E; Gros, L; Jarrousse, C; Kervran, A1
Fehmann, HC; Habener, JF1
Bockaert, J; Carrette, J; Fehrentsz, JA; Hillaire-Buys, D; Landry, Y; Mousli, M; Rouot, B1
Beinfeld, MC1
Cooper, CW; Ishizuka, J; Murakami, M; Nickols, GA; Sumi, S; Thompson, JC; Townsend, CM1
D'Ambra, R; Efrat, S; Fleischer, N; Starr, RG; Surana, M1
Chiba, T; Fujita, T; Kadowaki, S; Morishita, T; Nakamura, A; Yamaguchi, A; Yamatani, T1
Efrat, S; Fleischer, N; Surana, M1
Nagamatsu, S; Nishi, M; Steiner, DF1
Billestrup, N; Nielsen, JH; Petersen, ED1
Danoff, A; Fleischer, N; Pasmantier, R; Schubart, UK1
Chiba, T; Fujita, T; Inui, T; Kadowaki, S; Saito, Y; Yamaguchi, A; Yamatani, T1
Gold, G; Grodsky, GM; Wieland, FT1
Schonbrunn, A; Sullivan, SJ1

Other Studies

55 other study(ies) available for colforsin and Insulinoma

ArticleYear
Glucagon-like peptide-1 stimulates type 3 iodothyronine deiodinase expression in a mouse insulinoma cell line.
    Life sciences, 2014, Oct-12, Volume: 115, Issue:1-2

    Topics: Animals; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Exenatide; Gene Expression Regulation, Neoplastic; Glucagon-Like Peptide 1; Insulin-Secreting Cells; Insulinoma; Iodide Peroxidase; Mice; Pancreatic Neoplasms; Peptides; RNA, Messenger; Signal Transduction; Triiodothyronine; Triiodothyronine, Reverse; Venoms

2014
Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis.
    Genes to cells : devoted to molecular & cellular mechanisms, 2009, Volume: 14, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Exocytosis; Glucose; Green Fluorescent Proteins; Immunoblotting; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Isoquinolines; Mice; Microscopy, Fluorescence; Microscopy, Immunoelectron; Mitochondrial Proteins; Okadaic Acid; Phosphorylation; Protein Transport; rab GTP-Binding Proteins; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Transfection

2009
Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1).
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2009, Volume: 41, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Colforsin; Gene Expression Regulation, Developmental; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Islets of Langerhans; Melatonin; Rats; Rats, Wistar

2009
Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1).
    Journal of pineal research, 2012, Volume: 53, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Colforsin; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Humans; Insulin-Secreting Cells; Insulinoma; Melatonin; Microscopy, Confocal; Pancreatic Neoplasms; Phosphorylation; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Time Factors; Transfection; Tryptamines

2012
Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.
    Journal of pineal research, 2002, Volume: 33, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Biological Transport; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Melatonin; Pancreatic Neoplasms; Phosphodiesterase Inhibitors; Polymerase Chain Reaction; Probenecid; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Signal Transduction; Tryptamines; Tumor Cells, Cultured

2002
Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.
    Diabetes, 2005, Volume: 54, Issue:3

    Topics: Animals; Calcium; Calcium Channels; Cell Line, Tumor; Cell Membrane; Cell-Free System; Colforsin; Exocytosis; gamma-Aminobutyric Acid; Glucose; Insulinoma; Islets of Langerhans; Rats; Secretory Vesicles

2005
Adrenomedullin inhibits insulin exocytosis via pertussis toxin-sensitive G protein-coupled mechanism.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 291, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adrenomedullin; Calcium; Cell Line, Tumor; Colforsin; Exocytosis; Formazans; Glucose; GTP-Binding Proteins; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Membrane Potentials; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Phosphodiesterase Inhibitors; Tetrazolium Salts

2006
Efficient high-throughput discovery of large peptidic hormones and biomarkers.
    Journal of proteome research, 2006, Volume: 5, Issue:7

    Topics: Amino Acid Sequence; Animals; Biomarkers, Tumor; Cell Line, Tumor; Colforsin; Computer Simulation; Culture Media, Conditioned; Drug Evaluation, Preclinical; Hormones; Insulinoma; Molecular Sequence Data; Pancreatic Neoplasms; Peptides; Proteomics; Rats

2006
Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells.
    Experimental cell research, 2007, Aug-15, Volume: 313, Issue:14

    Topics: Animals; Arachidonic Acids; Bombesin; Calcium; Cannabinoids; Capsaicin; Cell Line, Tumor; Colforsin; Dose-Response Relationship, Drug; Dronabinol; Enzyme Inhibitors; Estrenes; Insulinoma; Neuroprotective Agents; Neurotransmitter Agents; Pertussis Toxin; Phosphoinositide Phospholipase C; Pyrrolidinones; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sensory System Agents; Signal Transduction; Thapsigargin; TRPV Cation Channels

2007
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells.
    Journal of pineal research, 2008, Volume: 45, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line, Tumor; Colforsin; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide-Gated Cation Channels; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Guanylate Cyclase; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Melatonin; Pineal Gland; Rats; Rats, Wistar; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Tryptamines

2008
Glyceraldehyde, but not cyclic AMP-stimulated insulin release is preceded by a rise in cytosolic free Ca2+.
    FEBS letters, 1984, Nov-05, Volume: 177, Issue:1

    Topics: Aminoquinolines; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Diterpenes; Fluorescent Dyes; Glyceraldehyde; Insulin; Insulinoma; Membrane Potentials; Pancreatic Neoplasms

1984
Inhibition of adenylate cyclase activity by galanin in rat insulinoma cells is mediated by the G-protein Gi3.
    The Biochemical journal, 1994, Oct-15, Volume: 303 ( Pt 2)

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Antibody Specificity; Base Sequence; Colforsin; Electrophoresis, Polyacrylamide Gel; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique; Galanin; GTP-Binding Proteins; Insulin; Insulin Secretion; Insulinoma; Molecular Sequence Data; Neuropeptides; Oligonucleotides, Antisense; Pancreatic Neoplasms; Peptides; Pertussis Toxin; Phosphates; Protein Biosynthesis; Rats; Receptors, Galanin; Receptors, Gastrointestinal Hormone; Tumor Cells, Cultured; Virulence Factors, Bordetella

1994
Noradrenaline induces supersensitivity of adenylyl cyclase in NG108-15 and HT29-18 cells but not in the beta-cell RINm5F.
    Cellular signalling, 1995, Volume: 7, Issue:3

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glioma; Humans; Hybrid Cells; Insulinoma; Kinetics; Neuroblastoma; Norepinephrine; Pancreatic Neoplasms; Tumor Cells, Cultured

1995
Amylin alters the biological action of the incretin hormone GLP-1(7-36)amide.
    Life sciences, 1993, Volume: 53, Issue:17

    Topics: Adenylyl Cyclases; Amyloid; Animals; Cell Line; Colforsin; Cyclic AMP; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Intolerance; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Models, Biological; Peptide Fragments; Peptides; Rats; Substance P

1993
Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.
    Diabetes, 1995, Volume: 44, Issue:7

    Topics: Animals; Calcium; Calcium Channels; Cell Line; Colforsin; Cyclic AMP; Cytoplasm; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Peptide Fragments; Ryanodine; Time Factors; Tumor Cells, Cultured

1995
Okadaic acid indicates a major function for protein phosphatases in stimulus-response coupling of RINm5F rat insulinoma cells.
    Experimental and clinical endocrinology, 1994, Volume: 102, Issue:4

    Topics: Animals; Bucladesine; Carbachol; Colforsin; Cyclic AMP; Ethers, Cyclic; Insulin; Insulinoma; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Tumor Cells, Cultured

1994
Bimodal effect of transforming growth factor-beta on insulin secretion in MIN6 cells.
    Diabetes research and clinical practice, 1994, Volume: 26, Issue:1

    Topics: Animals; Colforsin; Dose-Response Relationship, Drug; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mice; Pancreatic Neoplasms; Tolbutamide; Transforming Growth Factor beta; Tumor Cells, Cultured

1994
Pituitary adenylate cyclase-activating polypeptide induces the voltage-independent activation of inward membrane currents and elevation of intracellular calcium in HIT-T15 insulinoma cells.
    Endocrinology, 1995, Volume: 136, Issue:4

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Calcium; Calcium Channels; Colforsin; Electric Conductivity; Fura-2; Insulin; Insulin Secretion; Insulinoma; Lanthanum; Manganese; Membrane Potentials; Neuropeptides; Pancreatic Neoplasms; Pituitary Adenylate Cyclase-Activating Polypeptide; Sodium Channels; Spectrometry, Fluorescence; Tumor Cells, Cultured

1995
Interaction of glucagon-like peptide-I (7-37) and somatostatin-14 on signal transduction and proinsulin gene expression in beta TC-1 cells.
    Metabolism: clinical and experimental, 1994, Volume: 43, Issue:6

    Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Drug Interactions; Gene Expression; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Mice; Pancreatic Neoplasms; Peptides; Proinsulin; Receptors, Cell Surface; Receptors, Glucagon; Signal Transduction; Somatostatin; Tumor Cells, Cultured

1994
Presence of somatostatin receptors negatively coupled to adenylate cyclase in ectopic growth hormone-releasing hormone- and alpha-subunit-secreting tumors from acromegalic patients responsive to octreotide.
    The Journal of clinical endocrinology and metabolism, 1994, Volume: 79, Issue:5

    Topics: Acromegaly; Adenylyl Cyclases; Adult; Carcinoid Tumor; Colforsin; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Immunohistochemistry; Insulinoma; Male; Multiple Endocrine Neoplasia Type 1; Octreotide; Pancreatic Neoplasms; Receptors, Somatostatin

1994
GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.
    The Journal of biological chemistry, 1994, Apr-15, Volume: 269, Issue:15

    Topics: 3-O-Methylglucose; Adenoviridae; Animals; Biological Transport; Cell Line; Colforsin; Gene Expression; Genetic Vectors; Glucokinase; Glucose; Glucose Transporter Type 2; Hexokinase; Humans; Insulin; Insulin Secretion; Insulinoma; Kinetics; Methylglucosides; Monosaccharide Transport Proteins; Pancreatic Neoplasms; Rats; RNA, Messenger; Transfection; Tumor Cells, Cultured

1994
Neuropeptide Y expression and regulation in a differentiated rat insulin-secreting cell line.
    Endocrinology, 1993, Volume: 133, Issue:3

    Topics: Adenylyl Cyclases; Animals; Cell Differentiation; Clonidine; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Neuropeptide Y; Pancreatic Neoplasms; Peptide Fragments; Protein Kinase C; Rats; Receptors, Neuropeptide Y; Tumor Cells, Cultured

1993
Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells.
    Regulatory peptides, 1995, Nov-10, Volume: 59, Issue:3

    Topics: Animals; Binding Sites; Binding, Competitive; Bradykinin; Cell Membrane; Colforsin; Cyclic AMP; Galanin; Guanosine Triphosphate; Insulinoma; Ligands; Peptide Fragments; Pertussis Toxin; Protein Binding; Rats; Receptors, Galanin; Receptors, Gastrointestinal Hormone; Recombinant Fusion Proteins; Tumor Cells, Cultured; Virulence Factors, Bordetella

1995
The signal transduction of the glucagon-like peptide 1 receptor: fishing beyond the protein kinase level.
    Acta physiologica Scandinavica, 1996, Volume: 157, Issue:3

    Topics: Colforsin; Electrophoresis, Gel, Two-Dimensional; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Isoelectric Focusing; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Precursors; Receptors, Glucagon; Signal Transduction; Tumor Cells, Cultured

1996
Ligand-induced regulation of glucagon-like peptide-I receptor function and expression in insulin-secreting beta cells.
    Pancreas, 1996, Volume: 13, Issue:3

    Topics: Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Protein Synthesis Inhibitors; Rats; Receptors, Glucagon; RNA, Messenger; Tumor Cells, Cultured

1996
Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, May-27, Volume: 94, Issue:11

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucose; Insulin; Insulin Secretion; Insulinoma; JNK Mitogen-Activated Protein Kinases; Kinetics; Mannoheptulose; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Tolbutamide; Tumor Cells, Cultured

1997
Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism.
    Molecular endocrinology (Baltimore, Md.), 1997, Volume: 11, Issue:11

    Topics: 3T3 Cells; Aluminum Compounds; Animals; Antibodies, Monoclonal; Astrocytes; Carbachol; Cell Line; CHO Cells; Colforsin; Cricetinae; Cricetulus; Embryo, Mammalian; Enzyme Activation; Enzyme Induction; Fluorides; Gene Expression Regulation, Enzymologic; Glucose; GTP-Binding Proteins; Insulin; Insulin Secretion; Insulinoma; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase Kinases; Pancreatic Neoplasms; PC12 Cells; Pheochromocytoma; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Receptors, Cell Surface; Recombinant Fusion Proteins; Signal Transduction; Transfection; Tumor Cells, Cultured

1997
Calcium-stimulated phosphorylation of MAP-2 in pancreatic betaTC3-cells is mediated by Ca2+/calmodulin-dependent kinase II.
    The Journal of biological chemistry, 1997, Oct-24, Volume: 272, Issue:43

    Topics: Adenylyl Cyclases; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Insulinoma; Islets of Langerhans; Isoquinolines; Kinetics; Microtubule-Associated Proteins; Pancreatic Neoplasms; Peptide Mapping; Phosphopeptides; Phosphorylation; Rats; Sulfonamides; Tumor Cells, Cultured

1997
Identification and expression of a novel isoform of cAMP response element modulator in the human heart.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1998, Volume: 12, Issue:12

    Topics: Animals; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP Response Element Modulator; Dimethyl Sulfoxide; DNA-Binding Proteins; Escherichia coli; Humans; Insulinoma; Myocardium; Pancreatic Neoplasms; Polymerase Chain Reaction; Recombinant Proteins; Repressor Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured

1998
Beta-cell gene expression and functional characterisation of the human insulinoma cell line CM.
    The Journal of endocrinology, 1999, Volume: 161, Issue:1

    Topics: Adenylyl Cyclases; Colforsin; Enzyme Activation; Gene Expression; Glucokinase; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 2; Humans; Insulin; Insulinoma; Islets of Langerhans; Models, Biological; Monosaccharide Transport Proteins; Stimulation, Chemical; Time Factors

1999
Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide.
    The Journal of endocrinology, 2000, Volume: 165, Issue:2

    Topics: Analysis of Variance; Animals; Colforsin; Cyclic AMP; Gastric Inhibitory Polypeptide; Glucose; Insulin; Insulinoma; Islets of Langerhans; Male; Mice; Pancreatic Neoplasms; Perfusion; Rats; Rats, Wistar; Signal Transduction; Tumor Cells, Cultured

2000
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
    Diabetes, 2000, Volume: 49, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoantigens; Colforsin; Cyclic AMP; Gene Expression Regulation; Glucagon; Glucose; Insulinoma; Islets of Langerhans; Kinetics; Membrane Proteins; Pancreatic Neoplasms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

2000
gamma-tocopherol partially protects insulin-secreting cells against functional inhibition by nitric oxide.
    Biochemical and biophysical research communications, 2000, Oct-22, Volume: 277, Issue:2

    Topics: Adenylyl Cyclases; Animals; Calcium; Calcium Channels; Carbachol; Cell Division; Cell Line; Cell Survival; Cholinergic Agonists; Colforsin; Cyclic GMP; Enzyme Inhibitors; Insulin; Insulin Secretion; Insulinoma; Interleukin-1; Islets of Langerhans; Models, Chemical; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Phorbol Esters; Protein Kinase C; Quinoxalines; Rats; Spermine; Type C Phospholipases; Vitamin E

2000
Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2b
    The Journal of biological chemistry, 2001, Apr-20, Volume: 276, Issue:16

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Arachidonic Acid; Colforsin; Enzyme Inhibitors; Glucose; Group VI Phospholipases A2; Humans; Insulin; Insulin Secretion; Insulinoma; Kinetics; Mice; Naphthalenes; Pancreatic Neoplasms; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Pyrones; Rats; Recombinant Proteins; Signal Transduction; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Transfection; Tumor Cells, Cultured

2001
The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1.
    Pflugers Archiv : European journal of physiology, 2001, Volume: 442, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Calcium; Colforsin; Electric Conductivity; Gene Expression Regulation; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Potassium Channel Blockers; Potassium Channels; Quaternary Ammonium Compounds; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetraethylammonium; Tolbutamide; Tumor Cells, Cultured

2001
Therapeutic differentiation of tumor-derived insulin-producing cells selected for resistance to diabetogenic drugs.
    International journal of experimental diabetes research, 2000, Volume: 1, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Drug Resistance; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Pancreatic Neoplasms; Rats; Streptozocin; Tumor Cells, Cultured

2000
cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells.
    The Journal of physiology, 2001, Oct-15, Volume: 536, Issue:Pt 2

    Topics: Animals; Caffeine; Calcium; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Exenatide; Gene Expression; Guanine Nucleotide Exchange Factors; Insulinoma; Ion Channel Gating; Islets of Langerhans; Pancreatic Neoplasms; Peptides; Phosphodiesterase Inhibitors; Rats; Ryanodine Receptor Calcium Release Channel; Transfection; Tumor Cells, Cultured; Venoms

2001
Stimulation of insulin secretion and associated nuclear accumulation of iPLA(2)beta in INS-1 insulinoma cells.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Nucleus; Colforsin; Cyclic AMP-Dependent Protein Kinases; Fluorescent Antibody Technique; Gene Expression; Glucose; Glycosylation; Group VI Phospholipases A2; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Phospholipases A; Phosphorylation; Rats; Signal Transduction; Transfection; Tumor Cells, Cultured

2002
The effects of amylin on insulin secretion from Rin m5F cells and glycogen synthesis and lipogenesis in rat primary cultured hepatocytes.
    Diabetes research and clinical practice, 1992, Volume: 15, Issue:1

    Topics: Acetates; Amyloid; Animals; Arginine; Blood Glucose; Cell Line; Cells, Cultured; Colforsin; Cyclic AMP; DNA Replication; Glucose; Glyceraldehyde; Insulin; Insulin Secretion; Insulinoma; Islet Amyloid Polypeptide; Isoproterenol; Kinetics; Lipid Metabolism; Liver; Liver Glycogen; Male; Mice; Mice, Inbred Strains; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Thymidine

1992
Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type Ca2+ channels.
    Molecular pharmacology, 1992, Volume: 42, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Membrane Permeability; Colforsin; Cricetinae; Diphosphonates; Drug Synergism; Insulin; Insulin Secretion; Insulinoma; Ion Channel Gating; Isoquinolines; Manganese; Membrane Potentials; Mitochondria; Piperazines; Protein Kinase Inhibitors; Stimulation, Chemical; Tumor Cells, Cultured

1992
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.
    Endocrinology, 1992, Volume: 130, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Colforsin; Insulin; Insulin Secretion; Insulinoma; Membrane Potentials; Mercaptoethanol; Pancreatic Neoplasms; Rats; Tumor Cells, Cultured

1992
Characterization of binding sites for oxyntomodulin on a somatostatin-secreting cell line (RIN T3).
    Endocrinology, 1992, Volume: 130, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Binding Sites; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucagon; Glucagon-Like Peptides; Insulinoma; Iodine Radioisotopes; Oxyntomodulin; Rats; Somatostatin; Tumor Cells, Cultured

1992
Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells.
    Endocrinology, 1992, Volume: 130, Issue:5

    Topics: Adenylate Cyclase Toxin; Animals; Blotting, Northern; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Galanin; Gene Expression; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Mice; Models, Biological; Pancreatic Neoplasms; Peptide Fragments; Peptides; Pertussis Toxin; Proinsulin; RNA, Neoplasm; Transfection; Virulence Factors, Bordetella

1992
Insulin releasing effects of mastoparan and amphiphilic substance P receptor antagonists on RINm5F insulinoma cells.
    Molecular and cellular biochemistry, 1992, Feb-12, Volume: 109, Issue:2

    Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Animals; Cholera Toxin; Colforsin; Exocytosis; GTP-Binding Proteins; Insulin; Insulin Secretion; Insulinoma; Intercellular Signaling Peptides and Proteins; Molecular Sequence Data; Neoplasm Proteins; Pancreatic Neoplasms; Peptide Fragments; Peptides; Pertussis Toxin; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Stimulation, Chemical; Structure-Activity Relationship; Substance P; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wasp Venoms

1992
CCK mRNA expression, pro-CCK processing, and regulated secretion of immunoreactive CCK peptides by rat insulinoma (RIN 5F) and mouse pituitary tumor (AtT-20) cells in culture.
    Neuropeptides, 1992, Volume: 22, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cholecystokinin; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Gene Expression; Insulinoma; Mice; Pancreatic Neoplasms; Pituitary Neoplasms; Protein Precursors; Rats; RNA, Messenger; Sincalide; Tumor Cells, Cultured

1992
Role of extracellular magnesium in insulin secretion from rat insulinoma cells.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1992, Volume: 200, Issue:4

    Topics: Animals; Calcium; Cell Line; Colforsin; Glyburide; Glyceraldehyde; Insulin; Insulin Secretion; Insulinoma; Kinetics; Magnesium; Pancreatic Neoplasms; Potassium Chloride; Rats; Tumor Cells, Cultured; Verapamil

1992
Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells.
    Endocrinology, 1990, Volume: 126, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Animals; Carbachol; Colforsin; Cyclic AMP; Drug Synergism; Glipizide; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Potassium; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1990
Activation of PKC inhibits NaF-induced inositol phospholipid turnover in rat insulinoma cells.
    The American journal of physiology, 1990, Volume: 259, Issue:1 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Protein Kinase C; Rats; Sodium Fluoride; Tumor Cells, Cultured

1990
Glucose induces insulin gene transcription in a murine pancreatic beta-cell line.
    The Journal of biological chemistry, 1991, Jun-15, Volume: 266, Issue:17

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Nucleus; Colforsin; Cyclic AMP; Gallopamil; Genes; Glucose; Insulin; Insulinoma; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Promoter Regions, Genetic; Rats; Transcription, Genetic; Uridine Triphosphate

1991
Biosynthesis of islet amyloid polypeptide. Elevated expression in mouse beta TC3 cells.
    The Journal of biological chemistry, 1991, Jul-25, Volume: 266, Issue:21

    Topics: Amyloid; Animals; Blotting, Northern; Colforsin; Dexamethasone; Gene Expression; Insulin; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Mice; Molecular Weight; Protein Precursors; Protein Processing, Post-Translational; RNA, Messenger; Secretory Rate; Tumor Cells, Cultured

1991
Effect of growth hormone and serum on the expression of the proto-oncogenes c-jun and c-fos in insulin producing cells.
    Biomedica biochimica acta, 1990, Volume: 49, Issue:12

    Topics: Adenylyl Cyclases; Animals; Blood; Colforsin; Cycloheximide; DNA Probes; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation; Insulin; Insulinoma; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Somatomedins; Transcription Factors; Tumor Cells, Cultured

1990
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
    Endocrinology, 1986, Volume: 119, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Animals; Colforsin; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Glucagon; Insulinoma; Isoproterenol; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Pituitary Neoplasms; Potassium; Rats; Tetradecanoylphorbol Acetate

1986
Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells.
    Biochemical and biophysical research communications, 1987, May-29, Volume: 145, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Carbachol; Colforsin; Cyclic AMP; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Phosphatidylinositols

1987
Unregulated secretion of an exogenous glycotripeptide by rat islets and HIT cells.
    Biochemical and biophysical research communications, 1988, Oct-14, Volume: 156, Issue:1

    Topics: Adenoma, Islet Cell; Animals; Cell Line; Colforsin; Egtazic Acid; Glucose; Glycopeptides; In Vitro Techniques; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Male; Pancreatic Neoplasms; Rats

1988
Distribution of somatostatin receptors in RINm5F insulinoma cells.
    Endocrinology, 1988, Volume: 122, Issue:3

    Topics: Adenoma, Islet Cell; Animals; Cell Fractionation; Cell Membrane; Colforsin; Cytoplasmic Granules; Cytosol; Glucagon; Glyceraldehyde; Insulin; Insulin Secretion; Insulinoma; Iodine Radioisotopes; Kinetics; Leucine; Microsomes; Pancreatic Neoplasms; Rats; Receptors, Neurotransmitter; Receptors, Somatostatin; Somatostatin; Tumor Cells, Cultured

1988