colforsin has been researched along with Disease Models, Animal in 130 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (3.08) | 18.7374 |
| 1990's | 19 (14.62) | 18.2507 |
| 2000's | 49 (37.69) | 29.6817 |
| 2010's | 47 (36.15) | 24.3611 |
| 2020's | 11 (8.46) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Cho, HJ; Choi, JY; Engelhardt, JF; Joo, NS; Milla, CE; Shinbashi, M; Wine, JJ | 1 |
| Beazley, S; Burmester, M; Campanucci, VA; Carmalt, JL; Duke, T; Fujiyama, M; Gray, B; Ianowski, JP; Jagadeeshan, S; Le, Y; Luan, X; Machen, TE; Murray, B; Shipley, A; Swekla, K; Tam, JS | 1 |
| Dagda, R; Dagda, RK; Grigoruta, M; Martinez, B; Vazquez-Mayorga, E | 1 |
| Andersson, Å; Kuo, A; Leen Lam, A; Lewis, R; Magiera, J; Meutermans, W; Rethwan, N; Smith, M; Wyse, B | 1 |
| Gioino, P; Grishchenko, N; Hassan, N; Ianowski, JP; Jagadeeshan, S; Luan, X; Machen, TE; Shipley, AM; Tam, JS | 1 |
| Amato, R; Bagnoli, P; Cammalleri, M; Dal Monte, M; Rusciano, D | 1 |
| Chen, H; Hao, H; Li, Q; Ma, X; Peng, Z; Wang, M; Xu, C; Xu, Z; Zhang, Y; Zhu, L | 1 |
| Birulina, YG; Buyko, EE; Efremkina, EP; Gusakova, SV; Ivanov, VV; Kovalev, IV; Nosarev, AV; Smagliy, LV | 1 |
| Alvear-Perez, R; Bonnet, D; De Mota, N; Estéoulle, L; Flahault, A; Girault-Sotias, PE; Iturrioz, X; Keck, M; Llorens-Cortes, C; Ramanoudjame, SM | 1 |
| Chen, WL; Ke, PX; Yuan, X; Zhang, GP; Zhang, GS; Zhang, X | 1 |
| Chen, R; Jia, Y; Lei, L; Liu, J; Liu, L; Lu, HAJ; Su, L; Yang, B; Zhou, H; Zhu, S | 1 |
| Chen, W; Huang, J; Liang, X; Liu, J; Ma, X; Nagao, N; Wang, J; Wang, Y; Weng, W | 1 |
| Shi, K; Shi, L; Xiong, B; You, ZP; Zhang, YL | 1 |
| Cheng, AB; Gao, XZ; Liu, TJ; Tan, ZB; Wang, JJ; Zhang, JC; Zhang, PP; Zhang, SB | 1 |
| Chahal, SK; Kaur, J; Kumar, R; Madan, J; Sodhi, RK | 1 |
| Bravo, CA; Levy, D; Oydanich, M; Vatner, DE; Vatner, SF; Yoon, S; Zhang, J | 1 |
| Grümmer, R; Koch, Y; Wimberger, P | 1 |
| Kumar, A; Singh, N | 2 |
| Hu, Y; Lu, C; Pan, M; Qu, J; Reinach, PS; Srinivasalu, N; Wen, Y; Zhou, X | 1 |
| Fan, SH; Han, XR; Hu, B; Li, MQ; Lu, J; Shan, Q; Shen, M; Sun, CH; Wang, S; Wang, YJ; Wen, X; Wu, DM; Zhang, ZF; Zheng, YL; Zhuang, J | 1 |
| Goldberg, AL; Lokireddy, S; VerPlank, JJS; Zhao, J | 1 |
| Ahlborn, R; Baltzer, S; Bleich, M; Compton, F; Dema, A; Eichhorst, J; Himmerkus, N; Hinze, C; Klussmann, E; Quintanova, C; Schmidt-Ott, KM; Vukićević, T; Wiesner, B; Zühlke, K | 1 |
| Hanazono, K; Itami, T; Makita, K; Oyama, N; Sano, T; Yamashita, K | 1 |
| Casazza, S; Di Prisco, S; Merega, E; Milanese, M; Pistoia, V; Pittaluga, A; Raffaghello, L; Summa, M; Uccelli, A | 1 |
| Amaro-Ortiz, A; D'Orazio, JA; Scott, TL; Vanover, JC | 1 |
| Choi, HJ; Kim, S; Moon, J; Park, JM | 1 |
| Asvadi, NH; Cabot, PJ; Herath, HM; Hewavitharana, AK; Morgan, M; Shaw, PN | 1 |
| Bauer, I; Behmenburg, F; Heinen, A; Hollmann, MW; Huhn, R; Schmidt, A; Stracke, N; Ströthoff, M | 1 |
| Antonio Chiocca, E; Dohi, E; Hide, I; Matsumoto, M; Miyagi, T; Saeki, Y; Sakai, N; Seki, T; Sotomaru, Y; Tanaka, S | 1 |
| Limjeerajarus, CN; Manokawinchoke, J; Osathanon, T; Pavasant, P | 1 |
| Adornetto, A; Bagetta, G; Cavaliere, F; Corasaniti, MT; Morrone, LA; Nucci, C; Rusciano, D; Russo, R; Varano, GP | 1 |
| Blanco, G; Calvet, JP; Jansson, K; Magenheimer, BS; Reif, GA; Sánchez, G; Venugopal, J; Wallace, DP | 1 |
| Aguilera, G; Hiraoka, Y; Jurek, B; Liu, Y; Neumann, ID; Nishimori, K; Slattery, DA; van den Burg, EH | 1 |
| Gong, WG; Ren, QG; Wang, YJ; Xu, L; Zhang, ZJ | 1 |
| Stroth, N; Svenningsson, P | 1 |
| Baekelandt, V; Beekman, JM; Bijvelds, MJ; Carlon, MS; da Cunha, MF; De Boeck, K; de Jonge, HR; Debyser, Z; Dekkers, JF; Edelman, A; Ferrante, M; Gijsbers, R; Hollenhorst, MI; Janssens, HM; Ramalho, AS; Sermet-Gaudelus, I; Van den Haute, C; Vidović, D | 1 |
| Ambrosio, SR; Simão, MR; Simplicio, JA; Tirapelli, CR | 1 |
| Owona, BA; Schluesener, HJ; Zhang, ZY; Zug, C | 1 |
| Balbo, SL; Bonfleur, ML; Carneiro, EM; Lubaczeuski, C; Maller, AC; Mendes, MC; Ribeiro, RA | 1 |
| Folts, CJ; Mayer-Pröschel, M; Noble, M; Pröschel, C; Scott-Hewitt, N | 1 |
| Abo-Elmatty, DM; Ahmed, AA; El-Baz, AA; Mosaad, SM; Moustafa, YM; Zaitone, SA | 1 |
| Battaglia, G; Bruno, V; Caruso, A; Girardi, P; Gruber, SH; Marchiafava, M; Mathè, AA; Matrisciano, F; Melchiorri, D; Nicoletti, F; Orlando, R; Tatarelli, R | 1 |
| Adwanikar, H; Fu, Y; Han, J; Ishola, T; Neugebauer, V; Ramsey, C; Scerbo, M | 1 |
| Alm, P; Efendic, S; Guenifi, A; Henningsson, R; Jimenez-Feltström, J; Lundquist, I; Mosén, H; Ostenson, CG; Salehi, A | 1 |
| Cui, H; Fu, W; Gao, J; Lu, B; Wang, H; Wang, Y; Yu, X; Yu, Y; Zhang, L | 1 |
| Bae, EH; Fenton, RA; Frøkiaer, J; Jensen, AM; Kim, SW; Nielsen, S; Nørregaard, R | 1 |
| Barman, SA; White, RE; Zhu, S | 1 |
| Bah, TM; D'Anjou, B; Godbout, R; Rousseau, G; Wann, BP; Webster, HH | 1 |
| Boucher, RC; Grubb, BR; Ostrowski, LE; Rogers, TD | 1 |
| Bajwa, PJ; Lee, JW; Lytle, C; Straus, DS | 1 |
| Jackson, EK; Mi, Z | 1 |
| Faingold, CL; Tupal, S | 1 |
| Molkentin, JD; Navedo, MF; Nieves-Cintrón, M; Santana, LF; Takeda, Y | 1 |
| Ehlert, FJ; Matsui, M; Ostrom, RS; Pak, KJ | 1 |
| Bian, JS; Goh, HS; Liu, YH; Lu, M; Wang, JJ; Wang, R; Yong, QC | 1 |
| Gao, J; Lei, T; Li, W; Li, X; Yang, B; Zhou, H; Zhou, L | 1 |
| Chen, YH; Liu, J; Ma, L; Qiang, D; Qing, C; Xu, Y; Yang, W; Zhang, M; Zhang, Y; Zhen, C | 1 |
| Bull, ND; DeKorver, NW; Johnson, TV; Martin, KR; Tomarev, SI; Welsapar, G | 1 |
| Blomhoff, HK; Blomhoff, R; Bogen, B; Follin-Arbelet, V; Hauglin, H; Hofgaard, PO; Naderi, S; Sundan, A | 1 |
| Baamonde, C; Dierssen, M; Flórez, J; Martínez-Cué, C | 1 |
| Busuttil, RW; Chang, WW; Gao, F; Huang, CY; Ji, H; Ke, B; Kupiec-Weglinski, JW; Lee, C; Shen, XD; Zhang, Y | 1 |
| Gao, J; Li, W; Li, X; Xia, Y; Yang, B; Zhou, H; Zhou, L | 1 |
| Christian, PA; D'Orazio, J; Donohue, KM; Ito, S; Kesler, MV; Scott, TL; Shelton, B; Wakamatsu, K | 1 |
| Hayashibe, K; Kusuhara, H; Kusuhara, S; Maruyama, K; Matsumiya, W; Negi, A; Schuetz, JD; Tagami, M | 1 |
| Makinodan, E; Marneros, AG | 1 |
| Cho, Y; Han, D; Heo, H; Joung, I; Kwon, YK; Yoo, M | 1 |
| Bermingham, JR; O'Connell, S; Rosenfeld, MG; Scherer, SS; Shumas, S; Sirkowski, EE; Whisenhunt, T | 1 |
| Ando, T; Ichikawa, T; Kajihara, H; Kikuchi, K; Miyake-Takagi, K; Omino, K; Takagi, N; Takeo, S; Tanonaka, K | 1 |
| Castresana, MR; McKinney, W; Newman, WH; Webb, JG | 1 |
| Abdel-Halim, SM; Ahrén, B; Efendic, S; Ljungberg, O; Lukinius, A; Portela-Gomes, GM | 1 |
| Chedid, NG; Díaz G, LE; Masuda, MO; Quintero H, CC; Saraiva, RM | 1 |
| Balsam, LB; Koransky, ML; Kown, MH; Lijkwan, MA; Martens, JM; Miniati, DN; Murata, S; Robbins, RC | 1 |
| Hall, KE; Neubig, RR; Shangguan, Y; Wiley, JW | 1 |
| Boyd, JG; Gordon, T; Sulaiman, O | 1 |
| Bendhack, LM; Callera, GE; Caperuto, LC; Carvalho, CR; Tostes, RC; Yeh, E | 1 |
| Anand-Srivastava, MB; Hashim, S | 1 |
| He, Q; Li, L; Liu, X; Lu, Y; Wang, K; Wang, X; Wang, Y; Zhang, H | 1 |
| Chang, YC; Ho, CJ; Huang, CC; Lee, HT; Wang, LY; Wang, ST | 1 |
| Levine, JD; Parada, CA; Reichling, DB | 1 |
| Abe, T; Komatsu, K; Matsuura, A; Morikawa, M; Nakashima, S; Sato, N | 1 |
| Goldshmidt, A; Hamill, CE; Hepler, JR; Lyuboslavsky, P; McKeon, RJ; Nicole, O; Sastre, A; Sorensen, SD; Traynelis, SF | 1 |
| Brose, N; Gibson, HE; Jones, S; Morton, AJ; Reim, K | 1 |
| Becker, TC; Cao, W; Collins, QF; Collins, S; Daniel, KW; Floering, L; Lupo, EG; Robidoux, J; Xiong, Y | 1 |
| Colledge, WH; Riederer, B; Seidler, U; Soleimani, M; Tuo, B; Wang, Z | 1 |
| Bosse, F; Hasenpusch-Theil, K; Küry, P; Müller, HW | 1 |
| Ko, SW; Petrovic, MJ; Sluka, KA; Vadakkan, KI; Wang, H; Zastepa, E; Zhuo, M | 1 |
| Bruins, MJ; Cermak, R; Kiers, JL; van Amelsvoort, JM; van der Meulen, J; van Klinken, BJ | 1 |
| Breitenbach, SC; Ghofrani, HA; Grimminger, F; Kirchrath, JM; Nilius, SM; Pullamsetti, SS; Rose, F; Schermuly, RT; Schrör, K; Seeger, W; Weissmann, N | 1 |
| Ameen, N; Melvin, JE; Vidyasagar, S; Zhang, H | 1 |
| Burns, KA; Grubb, BR; Kulaga, HM; Ostrowski, LE; Reed, RR; Rogers, TD; Wonsetler, RL | 1 |
| De Jonge, H; Leal, T; Lebacq, J; Lebecque, P; Lecourt, H; Lubamba, B; Wallemacq, P | 1 |
| Bruscia, E; Caputo, C; Egan, ME; Ferreira, EC; Krause, DS; Price, JE; Weiner, SA | 1 |
| Bot, A; Breves, G; Burmester, M; Charizopoulou, N; de Jonge, HR; Dorsch, M; Hedrich, HJ; Jansen, S; Leonhard-Marek, S; Stanke, F; Tóth, B; Tümmler, B; Wedekind, D; Wilke, M | 1 |
| Anand-Srivastava, MB; Li, Y; Saha, S | 1 |
| Berti-Mattera, LN; Douglas, JG; Goraya, TY; Wilkins, P; Zhou, J | 1 |
| Awaji, T; Haruno, A; Hashimoto, K; Hirasawa, A; Hosono, M | 1 |
| Dey, CR; DuVall, MD; Frizzell, RA; Wert, SE; Whitsett, JA; Zhou, L | 1 |
| D'Amico, TA; Koutlas, TC; Meyers, CH; Peterseim, DS; Sabiston, DC; Schwinn, DA; Van Trigt, P | 1 |
| Coureau, C; Escoubet, B; Hruby, M; Rabin, MR; Silve, C; Turner, G; Walrant, O | 1 |
| Diederich, M; Eschenhagen, T; Kluge, SH; Magnussen, O; Mene, U; Müller, F; Schmitz, W; Scholz, H; Sent, U; Weil, J | 1 |
| Díaz-Laviada, I; García-Barreno, P; Guillén, A; Haro, A; Nieto, JL | 1 |
| Black, C; Curry, C; Emala, C; Hirshman, CA; Levine, MA | 1 |
| Alton, EW; Delaney, SJ; Dorin, JR; Farley, R; Geddes, DM; Porteous, DJ; Smith, SN; Wainwright, BJ | 1 |
| Katusic, ZS; Onoue, H | 1 |
| Arrizurieta, E; Bertuccio, C; Ibarra, FR; Martin, RS; Paz, L; Pignataro, O; Toledo, J | 1 |
| Boyle, EM; Lille, S; Russell, RC; Schoeller, T; Suchy, H | 1 |
| Assie, MB; Carilla-Durand, E; Chopin, P; Colpaert, FC; Halazy, S; John, GW; Kleven, MS; Koek, W; Le Grand, B; Marien, M; Palmier, C; Pauwels, PJ; Perez, M; Tarayre, JP; Valentin, JP; Verscheure, Y; Wurch, T | 1 |
| Carroll, JF | 1 |
| Armstrong, J; Dong, E; Hagen, J; Kawai, H; Liang, CS; Mohan, A; Stevens, SY | 1 |
| Abraham, JA; Chen, MM; Joly, AH; Lam, A; Schreiner, GF | 1 |
| Benovic, JL; Kem, DC; Kyker, K; Patterson, E; Yu, X; Zhang, M | 1 |
| Cuthbert, AW | 1 |
| Aono, S; Higashiyama, S; Ishiguro, H; Keino, H; Matsui, F; Oohira, A; Tokita, Y | 1 |
| Beshay, E; Croze, F; Prud'homme, GJ | 1 |
| Cerasi, E; Efendic, S; Kaiser, N; Khan, A; Nesher, R; Warwar, N | 1 |
| Beales, IL | 1 |
| Ishiguro, Y; Morgan, JP | 1 |
| Brady, KG; Drumm, ML; Kelley, TJ | 1 |
| Gordon, T; Sulaiman, OA | 1 |
| Abrams, TA; Gregory, CY; Hall, MO | 1 |
| Boucher, RC; Clarke, LL; Gabriel, SE; Grubb, BR; Koller, BH; Smithies, O | 1 |
| Houslay, MD; Palmer, TM; Taberner, PV | 1 |
| Dawson, DA; Macrae, IM; McCulloch, J; Reid, JL; Robinson, MJ | 1 |
| Dartt, DA; Gilbard, JP; Heyda, KG; Rossi, SR | 1 |
| Katoh, A; Masuo, M; Sonoki, H; Sugimoto, T; Tomaru, T; Uchida, Y | 1 |
| Martinez, AM; Martinez, JR | 1 |
| Masaki, Y; Note, S; Ohguni, S; Tanigawa, K | 1 |
| Gherezghiher, T; Koss, MC; March, WF; Nordquist, RE | 1 |
130 other study(ies) available for colforsin and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model.
Topics: Animals; Carbachol; Colforsin; Cystic Fibrosis; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Ferrets; Isoproterenol; Mucociliary Clearance; Muscle Contraction; Muscle, Smooth; Swine | 2021 |
cAMP triggers Na
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Animals, Genetically Modified; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Epithelial Sodium Channel Blockers; Epithelial Sodium Channels; Epithelium; Ion Transport; Male; Sodium; Swine | 2021 |
Intraperitoneal Administration of Forskolin Reverses Motor Symptoms and Loss of Midbrain Dopamine Neurons in PINK1 Knockout Rats.
Topics: Animals; Colforsin; Disease Models, Animal; Dopaminergic Neurons; Humans; Levodopa; Mesencephalon; Neurodegenerative Diseases; Parkinson Disease; Protein Kinases; Rats; Substantia Nigra | 2022 |
In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile.
Topics: Analgesics, Opioid; Animals; beta-Arrestin 2; Colforsin; Constipation; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Ligands; Rats; Receptors, Opioid; Respiratory Insufficiency | 2020 |
Airway submucosal glands from cystic fibrosis swine suffer from abnormal ion transport across the serous acini, collecting duct, and ciliated duct.
Topics: Acinar Cells; Animals; Carbachol; Cations, Monovalent; Chlorides; Cilia; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Electrochemical Techniques; Electrodes; Gene Deletion; Gene Expression; Humans; Ion Transport; Lung; Potassium; Sodium; Swine | 2020 |
A Dietary Combination of Forskolin with Homotaurine, Spearmint and B Vitamins Protects Injured Retinal Ganglion Cells in a Rodent Model of Hypertensive Glaucoma.
Topics: Animals; Colforsin; Dietary Supplements; Disease Models, Animal; Female; Glaucoma; Intraocular Pressure; Male; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Nutritional Physiological Phenomena; Ocular Hypertension; Retinal Ganglion Cells; Taurine; Vitamin B Complex | 2020 |
The cyclic adenosine monophosphate elevating medicine, forskolin, reduces neointimal formation and atherogenesis in mice.
Topics: Animals; Aorta; Atherosclerosis; Blood Pressure; Cell Proliferation; Colforsin; Cyclic AMP; Disease Models, Animal; Endothelial Cells; Endothelium; Hyperplasia; Inflammation; Leukocytes; Medicine; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Signal Transduction | 2020 |
Regulation of Vascular Smooth Muscle Contractions in the Model of Metabolic Syndrome.
Topics: Acetylcholine; Animals; Aorta; Body Weight; Calcium; Carbohydrates; Colforsin; Disease Models, Animal; Endothelium, Vascular; Glucose; Hemodynamics; Lipids; Male; Metabolic Syndrome; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Nitroprusside; Phenylephrine; Potassium Channels; Rats; Rats, Wistar; Stress, Mechanical; Triglycerides; Vasoconstriction | 2020 |
A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia.
Topics: Amino Acid Sequence; Animals; Apelin; Apelin Receptors; Arginine Vasopressin; Blood Glucose; Blood Pressure; Cell Line; Colforsin; Cyclic AMP; Deamino Arginine Vasopressin; Disease Models, Animal; Diuresis; Electrolytes; Half-Life; Hyponatremia; Kidney Tubules, Collecting; Male; Mice; Models, Biological; Myocardial Contraction; Peptides; Phosphorylation; Rats, Sprague-Dawley; Tolvaptan | 2021 |
Forskolin Protected against Streptozotocin-Induced Diabetic Cardiomyopathy via Inhibition of Oxidative Stress and Cardiac Fibrosis in Mice.
Topics: Actins; Animals; Apoptosis; Colforsin; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Heart; Humans; Mice; Myocardium; Oxidative Stress; Transforming Growth Factor beta | 2021 |
Ganoderma triterpenes retard renal cyst development by downregulating Ras/MAPK signaling and promoting cell differentiation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Differentiation; Cell Line; Cell Proliferation; Colforsin; Cysts; Disease Models, Animal; Down-Regulation; Epithelial Cells; Ganoderma; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; ras Proteins; Signal Transduction; TOR Serine-Threonine Kinases; Triterpenes; TRPP Cation Channels | 2017 |
Inhibition of airway remodeling and inflammation by isoforskolin in PDGF-induced rat ASMCs and OVA-induced rat asthma model.
Topics: Airway Remodeling; Animals; Anti-Asthmatic Agents; Asthma; Colforsin; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Male; Mice; Myocytes, Smooth Muscle; Ovalbumin; Platelet-Derived Growth Factor; Random Allocation; Rats; Rats, Sprague-Dawley | 2017 |
Forskolin attenuates retinal inflammation in diabetic mice.
Topics: Animals; Blood Glucose; Body Weight; Colforsin; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Glucose Transporter Type 1; Inflammation Mediators; Leukostasis; Male; Mice; Retinal Vessels; Retinitis | 2018 |
Effect of sevoflurane on the ATPase activity of hippocampal neurons in a rat model of cerebral ischemia-reperfusion injury via the cAMP-PKA signaling pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Colforsin; CREB-Binding Protein; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Gene Expression Regulation; Germ-Free Life; Hippocampus; Humans; Infarction, Middle Cerebral Artery; Isoquinolines; Male; Neurons; Neuroprotective Agents; Platelet Aggregation Inhibitors; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sevoflurane; Sodium-Potassium-Exchanging ATPase; Sulfonamides | 2018 |
Forskolin convalesces memory in high fat diet-induced dementia in wistar rats-Plausible role of pregnane x receptors.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Biomarkers; Brain; Cholesterol, Dietary; Cognition; Colforsin; Cytokines; Dementia; Diet, High-Fat; Disease Models, Animal; Female; Glutathione; GPI-Linked Proteins; Male; Maze Learning; Memory; Neuroprotective Agents; Oxidative Stress; Peroxidase; Pregnane X Receptor; Rats, Wistar; Receptors, Steroid; Signal Transduction; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2018 |
A novel adenylyl cyclase type 5 inhibitor that reduces myocardial infarct size even when administered after coronary artery reperfusion.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Disease Models, Animal; Enzyme Inhibitors; Heart Failure; Humans; Mice; Myocardial Infarction; Myocardial Reperfusion; Receptors, Adrenergic, beta; Signal Transduction | 2018 |
Human chorionic gonadotropin induces decidualization of ectopic human endometrium more effectively than forskolin in an in-vivo endometriosis model.
Topics: Animals; Chorionic Gonadotropin; Colforsin; Disease Models, Animal; Endometriosis; Endometrium; Female; Forkhead Box Protein O1; Gene Expression Profiling; Histocytochemistry; Humans; Immunohistochemistry; Ki-67 Antigen; Mice, SCID; Microscopy; Progesterone; Prolactin; Real-Time Polymerase Chain Reaction; Reproductive Control Agents | 2018 |
Calcineurin Inhibition and Protein Kinase A Activation Limits Cognitive Dysfunction and Histopathological Damage in a Model of Dementia of the Alzheimer's Type.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Brain; Calcineurin; Calcineurin Inhibitors; Cholinesterase Inhibitors; Cognition Disorders; Colforsin; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Donepezil; Drug Therapy, Combination; Female; Glutathione; Male; Maze Learning; Mice; Peroxidase; Streptozocin; Tacrolimus; Thiobarbituric Acid Reactive Substances; Vasodilator Agents | 2018 |
Role of Cyclic Adenosine Monophosphate in Myopic Scleral Remodeling in Guinea Pigs: A Microarray Analysis.
Topics: Animals; Colforsin; Cyclic AMP; Disease Models, Animal; Down-Regulation; Fibril-Associated Collagens; Gene Expression Profiling; Gene Expression Regulation; Guinea Pigs; Microarray Analysis; Myopia; Real-Time Polymerase Chain Reaction; Sclera; Sensory Deprivation | 2018 |
Inhibition of microRNA-200a Upregulates the Expression of Striatal Dopamine Receptor D2 to Repress Apoptosis of Striatum via the cAMP/PKA Signaling Pathway in Rats with Parkinson's Disease.
Topics: Animals; Apoptosis; Colforsin; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Down-Regulation; Genetic Therapy; Male; MicroRNAs; Parkinson Disease; Rats, Sprague-Dawley; Receptors, Dopamine D2; Signal Transduction; Up-Regulation | 2018 |
26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Epinephrine; Glucagon; Hepatocytes; Humans; Kidney; Male; Mice; Muscle, Skeletal; Phosphorylation; Proteasome Endopeptidase Complex; Proteolysis; Proteostasis Deficiencies; Rats; Rats, Sprague-Dawley; Rats, Wistar; Ubiquitinated Proteins | 2019 |
Fluconazole Increases Osmotic Water Transport in Renal Collecting Duct through Effects on Aquaporin-2 Trafficking.
Topics: Analysis of Variance; Animals; Aquaporin 2; Biological Transport; Cell Membrane; Cells, Cultured; Colforsin; Diabetes Insipidus, Nephrogenic; Disease Models, Animal; Fluconazole; Kidney Tubules, Collecting; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphorylation; Random Allocation; rhoA GTP-Binding Protein; Signal Transduction; Statistics, Nonparametric | 2019 |
Cardiovascular effects of intravenous colforsin in normal and acute respiratory acidosis canine models: A dose-response study.
Topics: Acidosis, Respiratory; Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Catecholamines; Colforsin; Disease Models, Animal; Dobutamine; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Male; Pulmonary Artery; Vascular Resistance | 2019 |
CCL5-glutamate interaction in central nervous system: Early and acute presynaptic defects in EAE mice.
Topics: Age Factors; Animals; Animals, Newborn; Central Nervous System; Chemokine CCL5; Colforsin; D-Aspartic Acid; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Exocytosis; Female; Glutamic Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Potassium Chloride; Second Messenger Systems; Synaptosomes; Time Factors; Tritium | 2013 |
Pharmacologic induction of epidermal melanin and protection against sunburn in a humanized mouse model.
Topics: Animals; Colforsin; Cyclic AMP; Disease Models, Animal; Epidermis; Erythema; Glycoproteins; Mice; Plant Extracts; Plant Roots; Plectranthus; Radiation Tolerance; Skin; Skin Pigmentation; Sunburn; Toxins, Biological; Ultraviolet Rays | 2013 |
Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress.
Topics: alpha-Synuclein; Animals; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dark Adaptation; Disease Models, Animal; Dopamine beta-Hydroxylase; Exploratory Behavior; Female; Humans; Mice; Mice, Transgenic; Mutation; Restraint, Physical; Stress, Physiological; Time Factors; Transfection; Up-Regulation | 2014 |
Beta-endorphin 1-31 biotransformation and cAMP modulation in inflammation.
Topics: Animals; beta-Endorphin; Cell Line; Colforsin; Cyclic AMP; Disease Models, Animal; Gene Expression; Humans; Hydrogen-Ion Concentration; Inflammation; Male; Metabolic Networks and Pathways; Peptides; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 2014 |
Pharmacological options to protect the aged heart from ischemia and reperfusion injury by targeting the PKA-BK(Ca) signaling pathway.
Topics: Age Factors; Aging; Animals; Benzimidazoles; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Large-Conductance Calcium-Activated Potassium Channels; Male; Molecular Targeted Therapy; Myocardial Reperfusion Injury; Myocardium; Potassium Channel Blockers; Rats, Wistar; Signal Transduction | 2014 |
Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli.
Topics: Age Factors; Animals; Apoptosis; Cardiotonic Agents; Cell Survival; Cerebellum; Colforsin; Culture Media, Conditioned; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Ischemia; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Signal Transduction | 2014 |
Iloprost up-regulates vascular endothelial growth factor expression in human dental pulp cells in vitro and enhances pulpal blood flow in vivo.
Topics: Adolescent; Adult; Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dental Pulp; Dental Pulp Exposure; Disease Models, Animal; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2; Humans; Iloprost; Molar; Neovascularization, Physiologic; Platelet-Derived Growth Factor; Rats; Receptors, Fibroblast Growth Factor; Regional Blood Flow; Vascular Endothelial Growth Factor A; Young Adult | 2014 |
Intravitreal injection of forskolin, homotaurine, and L-carnosine affords neuroprotection to retinal ganglion cells following retinal ischemic injury.
Topics: Animals; Carnosine; Cell Survival; Colforsin; Disease Models, Animal; Drug Synergism; Glaucoma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Intraocular Pressure; Intravitreal Injections; Ischemia; Male; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Retinal Ganglion Cells; Retinal Vessels; Signal Transduction; Taurine | 2015 |
Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells.
Topics: Animals; Anions; Biological Transport; Cell Membrane; Chlorides; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Gene Knockout Techniques; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Mice, Knockout; Organ Culture Techniques; Ouabain; Polycystic Kidney, Autosomal Dominant; Primary Cell Culture; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase | 2015 |
Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated Transcription Coactivator 3.
Topics: Animals; Cells, Cultured; Colforsin; Corticotropin-Releasing Hormone; CREB-Binding Protein; Disease Models, Animal; Female; Gene Expression Regulation; Hypothalamus; Male; Mice; Mice, Inbred C57BL; Neurons; Oxytocics; Oxytocin; Protein Transport; Rats; Rats, Wistar; Receptors, Oxytocin; Signal Transduction; Stress, Psychological; Thromboplastin | 2015 |
Escitalopram Ameliorates Tau Hyperphosphorylation and Spatial Memory Deficits Induced by Protein Kinase A Activation in Sprague Dawley Rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Citalopram; Colforsin; Disease Models, Animal; Enzyme Activation; Exploratory Behavior; Food Preferences; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Maze Learning; Memory Disorders; Mood Disorders; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reaction Time; Serine; tau Proteins | 2015 |
S100B interacts with the serotonin 5-HT7 receptor to regulate a depressive-like behavior.
Topics: Animals; Animals, Newborn; Astrocytes; Brain; Cells, Cultured; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Depression; Disease Models, Animal; Female; Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Molecular; Neurotransmitter Agents; Receptors, Serotonin; S100 Calcium Binding Protein beta Subunit; Swimming | 2015 |
rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice.
Topics: Animals; Body Fluids; Chloride Channels; Chlorides; Colforsin; Cystic Fibrosis; Dependovirus; Disease Models, Animal; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Genotype; HeLa Cells; Humans; Intestines; Mice; Organoids; Transduction, Genetic | 2016 |
The Labdane Ent-3-Acetoxy-Labda-8(17), 13-Dien-15-Oic Decreases Blood Pressure In Hypertensive Rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Colforsin; Disease Models, Animal; Diterpenes; Drug Evaluation, Preclinical; Hypertension, Renovascular; Male; Muscle, Smooth, Vascular; Nitric Oxide; Phenylephrine; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2016 |
Protective Effects of Forskolin on Behavioral Deficits and Neuropathological Changes in a Mouse Model of Cerebral Amyloidosis.
Topics: Amyloid beta-Protein Precursor; Amyloidosis; Animals; Colforsin; Disease Models, Animal; Interpersonal Relations; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Presenilin-1; Treatment Outcome | 2016 |
Vagotomy diminishes obesity in cafeteria rats by decreasing cholinergic potentiation of insulin release.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Body Weight; Carbachol; Colforsin; Cyclic AMP; Diet, High-Fat; Disease Models, Animal; Glucose; Hyperglycemia; Hyperinsulinism; Hypertriglyceridemia; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Male; Obesity; Rats; Rats, Wistar; Tissue Culture Techniques; Vagotomy; Vagus Nerve | 2016 |
Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity.
Topics: Acids; Animals; Colforsin; Disease Models, Animal; Humans; Lysosomal Storage Diseases; Lysosomes; Mice; Sphingolipids; Stem Cells | 2016 |
Evening primrose oil or forskolin ameliorates celecoxib-enhanced upregulation of tissue factor expression in mice subjected to lipopolysaccharide-induced endotoxemia.
Topics: Animals; Antithrombin III; Blood Coagulation; Celecoxib; Colforsin; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Endotoxemia; Fibrinolytic Agents; gamma-Linolenic Acid; Linoleic Acids; Lipopolysaccharides; Lung; Male; Mice; Oenothera biennis; Peptide Hydrolases; Plant Oils; Thromboplastin; Thrombosis; Up-Regulation | 2017 |
Pharmacological activation of protein kinase A improves memory loss and neuropathological changes in a mouse model of dementia of Alzheimer's type.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dementia; Disease Models, Animal; Female; Glutathione; Male; Maze Learning; Memory Disorders; Mice; Streptozocin | 2017 |
Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats.
Topics: Amino Acids; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Clomipramine; Colforsin; Cyclic AMP; Depression; Disease Models, Animal; Drug Interactions; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Methoxyhydroxyphenylglycol; Rats; Receptors, Metabotropic Glutamate; RNA, Messenger; Swimming | 2008 |
PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior.
Topics: Amygdala; Animals; Arthritis; Behavior; Butadienes; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Indoles; Male; Maleimides; Neuronal Plasticity; Neurons; Nitriles; Pain; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Thionucleotides | 2008 |
Impaired glucose-stimulated insulin secretion in the GK rat is associated with abnormalities in islet nitric oxide production.
Topics: Animals; Arginine; Colforsin; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Inhibitors; Female; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar | 2008 |
Antiarrhythmic effect of acupuncture pretreatment in rats subjected to simulative global ischemia and reperfusion--involvement of adenylate cyclase, protein kinase A, and L-type Ca2+ channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Arrhythmias, Cardiac; Calcium Channel Agonists; Calcium Channels, L-Type; Calcium Signaling; Colforsin; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Electroacupuncture; Electrocardiography; Enzyme Activation; Enzyme Activators; Heart Rate; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1 | 2008 |
Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction.
Topics: Adenylyl Cyclases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aquaporin 2; Benzimidazoles; Biphenyl Compounds; Colforsin; Cyclic AMP; Disease Models, Animal; GTP-Binding Protein alpha Subunits, Gs; Kidney Medulla; Male; Rats; Rats, Wistar; Receptors, Vasopressin; RNA, Messenger; Sodium Fluoride; Tetrazoles; Ureteral Obstruction | 2009 |
Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Disease Models, Animal; Hypertension, Pulmonary; Milrinone; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Potassium Channels, Calcium-Activated; Protein Kinase C; Pulmonary Artery; Purinones; Rats; Vasoconstriction | 2008 |
Effect of olfactory bulbectomy on adenylyl cyclase activity in the limbic system.
Topics: Adenylyl Cyclases; Animals; Blotting, Western; Colforsin; Cyclic AMP; Depressive Disorder; Disease Models, Animal; Enzyme Activators; GTP-Binding Proteins; Limbic System; Male; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Sodium Fluoride | 2009 |
Ion transport across CF and normal murine olfactory and ciliated epithelium.
Topics: Age Factors; Amiloride; Animals; Chlorides; Cilia; Colforsin; Cystic Fibrosis; Disease Models, Animal; Humans; Ion Transport; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CFTR; Nasal Cavity; Nasopharynx; Olfactory Mucosa; Respiratory Mucosa; Sodium; Tissue Culture Techniques | 2009 |
Activation of PPARgamma by rosiglitazone attenuates intestinal Cl- secretion.
Topics: Administration, Oral; Animals; Calcium; Carbachol; Chlorides; Cholera Toxin; Colforsin; Colon; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Diarrhea; Disease Models, Animal; Electric Impedance; Female; Gastrointestinal Agents; HT29 Cells; Humans; Ileum; Intermediate-Conductance Calcium-Activated Potassium Channels; Intestinal Mucosa; Intestinal Secretions; Intestines; Jejunum; KCNQ1 Potassium Channel; Mice; Pioglitazone; PPAR gamma; Rosiglitazone; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Thiazolidinediones; Time Factors | 2009 |
Regulation of renovascular adenosine 3',5'-cyclic monophosphate in spontaneously hypertensive rats.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Analysis of Variance; Animals; Blood Pressure; Blood Pressure Determination; Colforsin; Cyclic AMP; Disease Models, Animal; Hypertension, Renovascular; Isoproterenol; Kidney; Male; Probability; Random Allocation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values; Renal Circulation; Sensitivity and Specificity; Xanthines | 2009 |
Precipitous induction of audiogenic kindling by activation of adenylyl cyclase in the amygdala.
Topics: Acoustic Stimulation; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amygdala; Animals; Colforsin; Disease Models, Animal; Electroencephalography; Enzyme Activation; Epilepsy, Reflex; Functional Laterality; Kindling, Neurologic; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2010 |
Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells.
Topics: A Kinase Anchor Proteins; Animals; Blood Glucose; Calcium Channels, L-Type; Calcium Signaling; Cerebral Arteries; Colforsin; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Hyperglycemia; Intracellular Signaling Peptides and Proteins; Membrane Potentials; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Kinase C-alpha; Protein Kinase Inhibitors; Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Up-Regulation | 2010 |
Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder.
Topics: Animals; Colforsin; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Muscle Contraction; Oxotremorine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Streptozocin; Time Factors; Urinary Bladder | 2010 |
Hydrogen sulfide inhibits plasma renin activity.
Topics: Adenylyl Cyclases; Animals; Blood Pressure; Cells, Cultured; Colforsin; Cyclic AMP; Disease Models, Animal; Hydrogen Sulfide; Hypertension; Kidney; Male; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System; Sulfides | 2010 |
Curcumin inhibits renal cyst formation and enlargement in vitro by regulating intracellular signaling pathways.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Colforsin; Curcumin; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Mice; Polycystic Kidney Diseases; Signal Transduction | 2011 |
Isoforskolin pretreatment attenuates lipopolysaccharide-induced acute lung injury in animal models.
Topics: Acute Lung Injury; Animals; Cell Adhesion; Cells, Cultured; Coleus; Colforsin; Cytokines; Disease Models, Animal; Enzyme Activation; Humans; Inflammation Mediators; Leukocytes, Mononuclear; Lipopolysaccharides; Lung; Mice; Neutrophils; Peroxidase; Rats | 2011 |
Use of an adult rat retinal explant model for screening of potential retinal ganglion cell neuroprotective therapies.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Caspase Inhibitors; Cell Survival; Cells, Cultured; Coculture Techniques; Colforsin; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mesenchymal Stem Cells; Nerve Crush; Neuroprotective Agents; Ocular Hypertension; Optic Nerve; Optic Nerve Diseases; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Stem Cell Transplantation | 2011 |
Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Survival; Colforsin; Cyclic AMP; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Intracellular Space; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Multiple Myeloma; Poly(ADP-ribose) Polymerases; Thionucleotides; Time Factors; Tumor Burden | 2011 |
G-protein-associated signal transduction processes are restored after postweaning environmental enrichment in Ts65Dn, a Down syndrome mouse model.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Carbachol; Cholinergic Agonists; Colforsin; Cyclic AMP; Disease Models, Animal; Dopamine Agonists; Down Syndrome; Environment; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Isoproterenol; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Norepinephrine; Signal Transduction | 2011 |
Activation of cyclic adenosine monophosphate-dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice.
Topics: Animals; Apoptosis; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Inhibitors; Hepatocytes; Interleukin-10; Isoquinolines; Liver; Liver Transplantation; Macrophages; Male; Mice; Mice, Inbred C57BL; Necrosis; Peroxidase; Reperfusion Injury; Signal Transduction; Sulfonamides; Temperature | 2012 |
Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models.
Topics: Animals; Apoptosis; Cell Line; Cell Proliferation; Cell Survival; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Dogs; Female; Ginkgolides; In Vitro Techniques; Kidney; Lactones; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Transgenic; Plant Extracts; Polycystic Kidney, Autosomal Dominant; Pregnancy; Protein Kinase C | 2012 |
Pigment-independent cAMP-mediated epidermal thickening protects against cutaneous UV injury by keratinocyte proliferation.
Topics: Animals; Apoptosis; Cell Proliferation; Colforsin; Cyclic AMP; Disease Models, Animal; Epidermis; Humans; Keratin-14; Keratinocytes; Melanocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pigments, Biological; Skin; Skin Pigmentation; Ultraviolet Rays | 2012 |
Forskolin modifies retinal vascular development in Mrp4-knockout mice.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Proliferation; Colforsin; Cyclic AMP; Disease Models, Animal; Endothelium, Vascular; Humans; Immunohistochemistry; Infant, Newborn; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Multidrug Resistance-Associated Proteins; Oxygen; Retinal Vessels; Retinopathy of Prematurity | 2012 |
Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin.
Topics: Animals; Carcinoma, Basal Cell; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Female; Hedgehog Proteins; In Vitro Techniques; Kruppel-Like Transcription Factors; Male; Mice; Mice, Mutant Strains; Mutation; Receptors, G-Protein-Coupled; Signal Transduction; Skin Neoplasms; Smoothened Receptor; Zinc Finger Protein GLI1 | 2012 |
Upregulation of TrkB by forskolin facilitated survival of MSC and functional recovery of memory deficient model rats.
Topics: Adenylyl Cyclases; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Colforsin; Disease Models, Animal; gamma-Aminobutyric Acid; Genetic Therapy; Humans; Male; Maze Learning; Memory; Memory Disorders; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Neurons; Rats; Rats, Sprague-Dawley; Receptor, trkB; Recovery of Function; Regeneration; Transduction, Genetic; Up-Regulation | 2013 |
Identification of genes that are downregulated in the absence of the POU domain transcription factor pou3f1 (Oct-6, Tst-1, SCIP) in sciatic nerve.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Transport Systems; Animals; Avian Proteins; Carrier Proteins; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Membrane; Cells, Cultured; Colforsin; Cytoskeleton; Disease Models, Animal; Down-Regulation; Gene Expression Profiling; LIM Domain Proteins; Mice; Mice, Mutant Strains; Myelin Sheath; Octamer Transcription Factor-6; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schwann Cells; Sciatic Nerve; Sciatic Neuropathy; Transcription Factors | 2002 |
Effects of nefiracetam on cerebral adenylyl cyclase activity in rats with microsphere embolism-induced memory dysfunction.
Topics: Animals; Behavior, Animal; Blotting, Western; Body Weight; Brain Ischemia; Cell Membrane; Colforsin; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Embolism; Escape Reaction; GTP-Binding Proteins; Male; Maze Learning; Memory Disorders; Microspheres; Neuroprotective Agents; Pyrrolidinones; Rats; Rats, Wistar; Time Factors | 2003 |
Bacterial lipopolysaccharide-stimulated release of tumor necrosis factor-alpha from the isolated rat heart: the effect of aprotinin and forskolin.
Topics: Animals; Aprotinin; Cardiopulmonary Bypass; Colforsin; Cyclic AMP; Disease Models, Animal; Drug Evaluation, Preclinical; Heart; In Vitro Techniques; Inflammation; Lipopolysaccharides; Male; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha | 2003 |
PACAP is expressed in secretory granules of insulin and glucagon cells in human and rodent pancreas. Evidence for generation of cAMP compartments uncoupled from hormone release in diabetic islets.
Topics: Animals; Colforsin; Cyclic AMP; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Glucagon; Glucose; Humans; Immunohistochemistry; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Microscopy, Immunoelectron; Neuropeptides; Pancreas; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Wistar | 2003 |
Impaired beta-adrenergic response and decreased L-type calcium current of hypertrophied left ventricular myocytes in postinfarction heart failure.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Calcium Channels, L-Type; Colforsin; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiologic Techniques, Cardiac; Female; Heart Failure; Hypertrophy, Left Ventricular; Isoproterenol; Male; Myocardial Infarction; Myocytes, Cardiac; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Time Factors | 2003 |
Elevated cyclic adenosine monophosphate ameliorates ischemia-reperfusion injury in rat cardiac allografts.
Topics: Animals; Cardiotonic Agents; Cell Movement; Colforsin; Coronary Artery Disease; Cyclic AMP; Disease Models, Animal; E-Selectin; Endothelium, Vascular; Heart Transplantation; Immunoenzyme Techniques; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Models, Cardiovascular; Myocytes, Cardiac; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transplantation, Homologous; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2003 |
Diabetic neuropathy: inhibitory G protein dysfunction involves PKC-dependent phosphorylation of Goalpha.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Diabetic Neuropathies; Disease Models, Animal; Ganglia, Spinal; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Isoenzymes; Male; Narcotics; Neurons; Phosphorylation; Protein Kinase C; Protein Subunits; Rats; Rats, Sprague-Dawley | 2003 |
Experimental strategies to promote functional recovery after peripheral nerve injuries.
Topics: Animals; Autonomic Denervation; Axons; Axotomy; Brain-Derived Neurotrophic Factor; Cell Count; Colforsin; Dextrans; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Evoked Potentials, Motor; Humans; In Vitro Techniques; Mice; Mice, Knockout; Motor Neurons; Muscle Contraction; Nerve Degeneration; Nerve Growth Factors; Nerve Regeneration; Peripheral Nerve Injuries; Peripheral Nerves; Rats; Receptor, Nerve Growth Factor; Receptor, trkB; Receptors, Nerve Growth Factor; Recovery of Function; Rhodamines; Schwann Cells; Tacrolimus; Time Factors; Transforming Growth Factor beta | 2003 |
Changes in the vascular beta-adrenoceptor-activated signalling pathway in 2Kidney-1Clip hypertensive rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta, Thoracic; Caffeine; Calcium-Transporting ATPases; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Gene Expression; Glyburide; Hypertension, Renovascular; Isoproterenol; Kidney; Male; Membrane Proteins; Muscle, Smooth, Vascular; Phenylephrine; Potassium Channels; Rats; Rats, Wistar; Receptors, Adrenergic, beta; RNA, Messenger; Sarcolemma; Signal Transduction; Thapsigargin; Vasoconstriction; Vasodilation | 2004 |
Losartan-induced attenuation of blood pressure in L-NAME hypertensive rats is associated with reversal of the enhanced expression of Gi alpha proteins.
Topics: Adenylyl Cyclases; Animals; Antihypertensive Agents; Blood Pressure; Colforsin; Disease Models, Animal; Enzyme Inhibitors; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hypertension; Losartan; Male; Models, Cardiovascular; NG-Nitroarginine Methyl Ester; Proto-Oncogene Proteins; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; RNA, Messenger; Sodium Fluoride; Statistics as Topic | 2004 |
Distinct efficacy of pre-differentiated versus intact fetal mesencephalon-derived human neural progenitor cells in alleviating rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Cell Differentiation; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Colforsin; Corpus Striatum; Disease Models, Animal; Dopamine; Embryo, Mammalian; Female; Fibroblast Growth Factor 8; Fibroblast Growth Factors; Glial Cell Line-Derived Neurotrophic Factor; Glial Fibrillary Acidic Protein; Humans; Intermediate Filament Proteins; Ki-67 Antigen; Mesencephalon; Nerve Growth Factors; Nerve Tissue Proteins; Nestin; Neurofilament Proteins; Neurons; Parkinson Disease; Rats; Recovery of Function; Stem Cell Transplantation; Stem Cells; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
cAMP response element-binding protein activation in ligation preconditioning in neonatal brain.
Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Blotting, Western; Brain-Derived Neurotrophic Factor; Carotid Stenosis; Cerebrovascular Circulation; Colforsin; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Female; Fetal Hypoxia; Functional Laterality; Hypoxia-Ischemia, Brain; Immunohistochemistry; Ischemic Preconditioning; Ligation; Male; Maze Learning; Oligodeoxyribonucleotides, Antisense; Organ Size; Phosphodiesterase Inhibitors; Phosphorylation; Rats; Reaction Time; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rolipram; Serine; Time Factors | 2004 |
Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCepsilon second messenger pathways.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Analysis of Variance; Animals; Behavior, Animal; Carrageenan; Colforsin; Cyclic AMP; Cyclic GMP; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Hyperalgesia; Male; Models, Biological; Pain Measurement; Pain Threshold; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Thionucleotides | 2005 |
Antiproliferative effects of NKH477, a forskolin derivative, on cytokine profile in rat lung allografts.
Topics: Adjuvants, Immunologic; Animals; Cell Proliferation; Colforsin; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Graft Rejection; Graft Survival; Immunohistochemistry; Lung; Lung Transplantation; Lymph Nodes; Lymphocyte Culture Test, Mixed; Male; Rats; Rats, Inbred Lew; Spleen; Transplantation, Homologous | 2005 |
Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.
Topics: Amides; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Blotting, Northern; Blotting, Western; Brain Injuries; Bromodeoxyuridine; Butadienes; Cell Count; Cell Movement; Cell Proliferation; Cells, Cultured; Coculture Techniques; Colforsin; Cyclin D1; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Functional Laterality; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Male; MAP Kinase Kinase Kinases; Mice; Mice, Knockout; Microglia; Nitriles; Oligopeptides; Pyridines; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thrombin; Time Factors | 2005 |
A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse.
Topics: 2-Amino-5-phosphonovalerate; Adaptor Proteins, Vesicular Transport; Age Factors; Animals; Anticonvulsants; Colforsin; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Huntington Disease; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Patch-Clamp Techniques; Time Factors | 2005 |
p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis.
Topics: Acetylcysteine; Adenoviridae; Animals; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 1; Disease Models, Animal; Enzyme Inhibitors; Gene Silencing; Glucagon; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Hepatocytes; Imidazoles; Liver; Mice; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphoenolpyruvate Carboxykinase (GTP); Phosphorylation; Promoter Regions, Genetic; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Streptozocin; Trans-Activators; Transcription Factors; Transfection | 2005 |
Involvement of the anion exchanger SLC26A6 in prostaglandin E2- but not forskolin-stimulated duodenal HCO3- secretion.
Topics: Animals; Antiporters; Bicarbonates; Carbachol; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dinoprostone; Disease Models, Animal; Duodenum; Humans; Intestinal Mucosa; Mice; Mice, Inbred Strains; Mice, Knockout; Sulfate Transporters | 2006 |
Gene expression profiling reveals that peripheral nerve regeneration is a consequence of both novel injury-dependent and reactivated developmental processes.
Topics: Animals; Animals, Newborn; Cells, Cultured; Colforsin; Disease Models, Animal; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Male; Nerve Regeneration; Oligonucleotide Array Sequence Analysis; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Schwann Cells; Sciatic Neuropathy; Time Factors | 2006 |
Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases.
Topics: Adenylyl Cyclases; Animals; Calcium; Calcium Signaling; Calmodulin; Chronic Disease; Colforsin; Cyclic AMP; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Pain; Spinal Cord | 2006 |
In vivo and in vitro effects of tea extracts on enterotoxigenic Escherichia coli-induced intestinal fluid loss in animal models.
Topics: Animals; Body Fluids; Colforsin; Dehydration; Disease Models, Animal; Dysentery; Electrolytes; Escherichia coli Infections; Female; Flavonoids; Gastrointestinal Agents; In Vitro Techniques; Intestinal Absorption; Jejunum; Plant Extracts; Rats; Rats, Sprague-Dawley; Swine; Tea | 2006 |
Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Inhalation; Animals; Cell Culture Techniques; Colforsin; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Female; Hypertension, Pulmonary; Iloprost; Infusions, Parenteral; Lung; Male; Myocytes, Smooth Muscle; Rabbits; Receptors, Epoprostenol; Vasodilator Agents | 2007 |
Acute inflammation alters bicarbonate transport in mouse ileum.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acute Disease; Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Bicarbonates; CD3 Complex; Chloride-Bicarbonate Antiporters; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Diarrhea; Disease Models, Animal; Electric Conductivity; Enzyme Activation; Enzyme Activators; Glyburide; Ileum; Inflammatory Bowel Diseases; Intestinal Secretions; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzoates | 2007 |
Olfactory epithelia exhibit progressive functional and morphological defects in CF mice.
Topics: Acetophenones; Adenylyl Cyclases; Aging; Aldehydes; Amiloride; Animals; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activators; Mice; Mice, Inbred CFTR; Microscopy, Electron, Scanning; Odorants; Olfactory Mucosa; Olfactory Receptor Neurons; Pentanols; Receptors, Odorant; RNA, Messenger; Smell; Sodium; Sodium Channel Blockers; Time Factors; Tissue Culture Techniques | 2007 |
Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis.
Topics: Animals; Chlorides; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Imidazoles; Injections, Intraperitoneal; Ion Transport; Membrane Potentials; Mice; Mice, Inbred CFTR; Nasal Mucosa; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Protein Modification, Translational; Purines; Sildenafil Citrate; Sulfones; Triazines; Vardenafil Dihydrochloride | 2008 |
Rectal potential difference and the functional expression of CFTR in the gastrointestinal epithelia in cystic fibrosis mouse models.
Topics: Animals; Benzoates; Colforsin; Colon; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Genotype; Intestinal Mucosa; Membrane Potentials; Mice; Mice, Inbred CFTR; Mice, Mutant Strains; Phenotype; Rectum; Reproducibility of Results; Thiazolidines | 2008 |
Very mild disease phenotype of congenic CftrTgH(neoim)Hgu cystic fibrosis mice.
Topics: Analysis of Variance; Animals; Body Weight; Carbachol; Chlorides; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Female; Fertility; Genetic Linkage; Genotype; Male; Mice; Mice, Congenic; Mice, Inbred CFTR; Microsatellite Repeats; Phenotype | 2008 |
Reduced levels of cyclic AMP contribute to the enhanced oxidative stress in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Angiotensin II; Animals; Cell Line; Cells, Cultured; Colforsin; Cyclic AMP; Disease Models, Animal; Down-Regulation; Enzyme Activation; Enzyme Activators; Hypertension; Isoproterenol; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidase 4; NADPH Oxidases; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides | 2008 |
Signal transduction alterations in peripheral nerves from streptozotocin-induced diabetic rats.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Signal Transduction; Streptozocin | 1995 |
Effects of a new forskolin derivative, NKH477, on canine ventricular arrhythmia models.
Topics: Analysis of Variance; Animals; Arrhythmias, Cardiac; Blood Pressure; Colforsin; Disease Models, Animal; Dogs; Electrocardiography; Epinephrine; Female; Heart Rate; Injections, Intravenous; Male; Myocardial Contraction; Ouabain; Vasodilator Agents | 1993 |
Correction of lethal intestinal defect in a mouse model of cystic fibrosis by human CFTR.
Topics: Animals; Base Sequence; Carrier Proteins; Chlorides; Colforsin; Colon; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Gene Expression; Genetic Therapy; Humans; Intestinal Mucosa; Intestine, Small; Membrane Proteins; Mice; Mice, Transgenic; Molecular Sequence Data; Neoplasm Proteins; Nerve Tissue Proteins; Promoter Regions, Genetic; Rats; Recombinant Proteins; RNA, Messenger; Tumor Suppressor Proteins | 1994 |
Desensitization of myocardial beta-adrenergic receptors and deterioration of left ventricular function after brain death.
Topics: Adenylyl Cyclases; Animals; Brain Death; Colforsin; Cyclic AMP; Disease Models, Animal; GTP-Binding Proteins; Isoproterenol; Myocardium; Radioligand Assay; Receptors, Adrenergic, beta; Sodium Fluoride; Swine; Ventricular Function, Left | 1995 |
Parathyroid hormone (PTH)/PTH-related protein receptor messenger ribonucleic acid expression and PTH response in a rat model of secondary hyperparathyroidism associated with vitamin D deficiency.
Topics: Adenylyl Cyclases; Animals; Calcium; Cell Membrane; Colforsin; Diaphyses; Disease Models, Animal; Femur; Food, Fortified; Hyperparathyroidism, Secondary; Isoproterenol; Kidney; Lactose; Male; Parathyroid Hormone; Phosphates; Rats; Rats, Wistar; Receptor, Parathyroid Hormone, Type 1; Receptors, Parathyroid Hormone; RNA, Messenger; Sodium Fluoride; Vitamin D; Vitamin D Deficiency | 1995 |
Bovine hereditary cardiomyopathy: an animal model of human dilated cardiomyopathy.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cardiomyopathies; Cardiomyopathy, Dilated; Catecholamines; Cattle; Cattle Diseases; Colforsin; Disease Models, Animal; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Heart; Heart Atria; Heart Ventricles; Humans; Isoproterenol; Manganese; Myocardial Contraction; Myocardium; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Reference Values; Sodium Fluoride; Ventricular Function, Right; Virulence Factors, Bordetella | 1995 |
Cardiac beta-adrenoceptors, G-proteins and adenylate cyclase regulation during myocardial hypertrophy.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Carbachol; Cardiomegaly; Cholera Toxin; Colforsin; Disease Models, Animal; Enzyme Activation; GTP-Binding Proteins; Isoproterenol; Myocardium; Pertussis Toxin; Receptors, Adrenergic, beta; Swine; Swine, Miniature; Virulence Factors, Bordetella | 1993 |
Impaired beta-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the basenji-greyhound dog model of airway hyperresponsiveness.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Bronchial Hyperreactivity; Bucladesine; Cholera Toxin; Colforsin; Dinoprostone; Disease Models, Animal; Dogs; Enzyme Activation; Immunoblotting; Isoproterenol; Lung; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Radioimmunoassay; Receptors, Adrenergic, beta; Trachea | 1993 |
Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Animals; Chlorides; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Jejunum; Levamisole; Mice; Mice, Mutant Strains; Phosphodiesterase Inhibitors; Rectum; Tetramisole; Trachea | 1998 |
The effect of subarachnoid hemorrhage on mechanisms of vasodilation mediated by cyclic adenosine monophosphate.
Topics: 4-Aminopyridine; Adenylyl Cyclases; Animals; Basilar Artery; Charybdotoxin; Colforsin; Cyclic AMP; Disease Models, Animal; Dogs; Endothelium, Vascular; Enzyme Activation; Female; Glyburide; Ischemic Attack, Transient; Male; Potassium Channel Blockers; Potassium Channels; Subarachnoid Hemorrhage; Vasodilation; Vasodilator Agents | 1998 |
Regulation of cell cyclic AMP in medullary thick ascending limb of Henle in a rat model of chronic renal failure.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Animals; Calcitonin; Cell Separation; Clonidine; Colforsin; Creatinine; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Glomerular Filtration Rate; In Vitro Techniques; Kidney Failure, Chronic; Loop of Henle; Male; Osmolar Concentration; Rats; Rats, Wistar; Vasopressins | 1998 |
Augmentation of cAMP improves muscle-flap survival and tissue inflammation in response to ischemia/reperfusion injury.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Culture Techniques; Cyclic AMP; Disease Models, Animal; Graft Survival; Inflammation; Ischemia; Male; Muscle, Skeletal; Rats; Rats, Wistar; Reference Values; Reperfusion Injury; Surgical Flaps | 1999 |
F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine.
Topics: Animals; Carotid Arteries; Colforsin; Cyclic AMP; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart; Hemodynamics; Humans; Hypothermia; In Vitro Techniques; Male; Migraine Disorders; Muscle, Smooth, Vascular; Neurons; Nitriles; Piperazines; Rabbits; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Saphenous Vein; Swine; Trigeminal Ganglion; Tryptamines | 1999 |
Post-beta-receptor defect in isolated hearts of obese-hypertensive rabbits.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiotonic Agents; Colforsin; Disease Models, Animal; Female; Heart; Heart Rate; Hypertension; Myocardial Contraction; Obesity; Rabbits; Random Allocation; Receptors, Adrenergic, beta; Signal Transduction | 1999 |
Alterations in cardiac adrenergic terminal function and beta-adrenoceptor density in pacing-induced heart failure.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Binding Sites; Cardiac Pacing, Artificial; Colforsin; Disease Models, Animal; Down-Regulation; Guanylyl Imidodiphosphate; Heart Failure; Hemodynamics; Myocardium; Nerve Endings; Norepinephrine; Rabbits; Receptors, Adrenergic, beta; Sympathetic Nervous System; Tyrosine 3-Monooxygenase; Ventricular Function, Left | 2000 |
CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis.
Topics: Adult; Aged; Animals; Animals, Newborn; Biomarkers; Blotting, Northern; Cells, Cultured; Colforsin; Collagen; Connective Tissue Growth Factor; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Female; Fibroblasts; Fibronectins; Fibrosis; Flavonoids; Genes, Reporter; Growth Substances; Heart Diseases; Heart Ventricles; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Luciferases; Male; MAP Kinase Signaling System; Middle Aged; Myocardial Infarction; Myocardium; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tissue Distribution; Transforming Growth Factor beta; Up-Regulation | 2000 |
Ischemic inactivation of G protein-coupled receptor kinase and altered desensitization of canine cardiac beta-adrenergic receptors.
Topics: Adenylyl Cyclases; Animals; beta-Adrenergic Receptor Kinases; Binding, Competitive; Blotting, Western; Colforsin; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; G-Protein-Coupled Receptor Kinase 5; Isoproterenol; Male; Myocardial Ischemia; Myocardium; Protein Serine-Threonine Kinases; Radioligand Assay; Receptors, Adrenergic, beta; Signal Transduction; Sodium-Potassium-Exchanging ATPase | 2000 |
Assessment of CFTR chloride channel openers in intact normal and cystic fibrosis murine epithelia.
Topics: Animals; Benzimidazoles; Calcium Channel Blockers; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Electric Conductivity; Intestinal Mucosa; Mice | 2001 |
Regulation of neuregulin expression in the injured rat brain and cultured astrocytes.
Topics: Animals; Astrocytes; Brain Injuries; Cells, Cultured; Cerebral Cortex; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Head Injuries, Penetrating; Neuregulins; Protein Isoforms; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; Receptor, ErbB-3; Signal Transduction; Tetradecanoylphorbol Acetate; Up-Regulation | 2001 |
The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Autoimmune Diseases; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Diabetes Mellitus, Type 1; Dibutyryl Cyclic GMP; Disease Models, Animal; Drug Evaluation, Preclinical; Enterotoxins; Enzyme Induction; Female; Interferon-gamma; Interleukin-12; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred NOD; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pentoxifylline; Phosphodiesterase Inhibitors; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rolipram; Tumor Necrosis Factor-alpha | 2001 |
Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.
Topics: Animals; Colforsin; Diabetes Mellitus, Type 2; Diazoxide; Disease Models, Animal; Disease Susceptibility; Gerbillinae; Glucagon; Glucagon-Like Peptide 1; Glucose; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Oxidation-Reduction; Peptide Fragments; Protein Kinase C; Protein Precursors; Rats; Rats, Sprague-Dawley; Reference Values; Signal Transduction; Tetradecanoylphorbol Acetate | 2001 |
Effect of platelet-activating factor on gastrin release from cultured rabbit G-cells.
Topics: Animals; Bombesin; Calcium Channels, L-Type; Cells, Cultured; Colforsin; Disease Models, Animal; Gastrin-Secreting Cells; Gastrins; Gastritis; Helicobacter Infections; Helicobacter pylori; Platelet Activating Factor; Protein Kinase C; Rabbits | 2001 |
Effect of endogenous catecholamine on myocardial stunning in a simulated ischemia model.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Carbachol; Catecholamines; Colforsin; Coronary Circulation; Disease Models, Animal; Ferrets; Fluorocarbons; Heart; In Vitro Techniques; Male; Models, Cardiovascular; Myocardial Stunning; Myocardium; Papillary Muscles; Propranolol; Reserpine | 2001 |
Examining basal chloride transport using the nasal potential difference response in a murine model.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Female; Humans; Ion Transport; Membrane Potentials; Mice; Mice, Inbred Strains; Nasal Mucosa; Thionucleotides | 2001 |
Transforming growth factor-beta and forskolin attenuate the adverse effects of long-term Schwann cell denervation on peripheral nerve regeneration in vivo.
Topics: Animals; Axons; Colforsin; Denervation; Disease Models, Animal; Female; Motor Neurons; Nerve Regeneration; Neurosurgical Procedures; Organ Culture Techniques; Peripheral Nerve Injuries; Peripheral Nerves; Prostheses and Implants; Rats; Rats, Sprague-Dawley; Recovery of Function; Schwann Cells; Time Factors; Tissue Transplantation; Transforming Growth Factor beta; Treatment Outcome; Wallerian Degeneration | 2002 |
cAMP production via the adenylyl cyclase pathway is reduced in RCS rat RPE.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Disease Models, Animal; Pigment Epithelium of Eye; Prostaglandins E; Rats; Rats, Mutant Strains; Receptors, Prostaglandin; Receptors, Purinergic; Retinal Degeneration; Signal Transduction; Vasodilator Agents | 1992 |
Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis.
Topics: Amiloride; Animals; Biological Transport; Cells, Cultured; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Epithelium; Intestinal Mucosa; Membrane Proteins; Mice; Mutation; Nasal Mucosa; Trachea | 1992 |
Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Cell Membrane; Cells, Cultured; Colforsin; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; GTP-Binding Proteins; Isoproterenol; Magnesium; Mice; Mice, Inbred CBA; Obesity; Secretin | 1992 |
Autoradiographic evaluation of forskolin and D1 dopamine receptor binding in a rat model of focal cerebral ischaemia.
Topics: Animals; Autoradiography; Cerebrovascular Circulation; Colforsin; Disease Models, Animal; Ischemic Attack, Transient; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1 | 1992 |
Stimulation of tear secretion by topical agents that increase cyclic nucleotide levels.
Topics: Administration, Topical; Animals; Colforsin; Disease Models, Animal; Female; Keratoconjunctivitis; Keratoconjunctivitis Sicca; Lacrimal Apparatus; Male; Nucleotides, Cyclic; Ophthalmic Solutions; Osmolar Concentration; Phosphodiesterase Inhibitors; Pilocarpine; Pro-Opiomelanocortin; Rabbits; Signal Transduction; Tears; Vasoactive Intestinal Peptide | 1990 |
[Effects of forskolin on canine congestive heart failure].
Topics: Animals; Blood Pressure; Colforsin; Dextrans; Disease Models, Animal; Dogs; Heart Failure; Heart Rate; Methoxamine; Myocardial Contraction; Peptide Hydrolases; Vascular Resistance | 1986 |
The reserpine-treated rat as an experimental animal model for cystic fibrosis: abnormal Cl transport in pancreatic acinar cells.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetylcholine; Amiloride; Animals; Biological Transport; Ceruletide; Chlorides; Colforsin; Cystic Fibrosis; Disease Models, Animal; Furosemide; Kinetics; Male; Pancreas; Rats; Rats, Inbred Strains; Reserpine; Vasoactive Intestinal Peptide | 1988 |
Rat fetal islets as a useful model for the study of insulin release failure.
Topics: Animals; Colforsin; Culture Techniques; Disease Models, Animal; Female; Fetus; Gliclazide; Insulin; Insulin Secretion; Islets of Langerhans; Pregnancy; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1987 |
Laser-induced glaucoma in rabbits.
Topics: Animals; Aqueous Humor; Colforsin; Disease Models, Animal; Glaucoma; Lasers; Ocular Hypertension; Optic Disk; Pilocarpine; Rabbits; Timolol; Trabecular Meshwork | 1986 |