colforsin has been researched along with B-Cell Chronic Lymphocytic Leukemia in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lerner, A; Moon, EY | 1 |
| Felekkis, K; Flies, A; Lerner, A; Moon, EY; Sherr, DH; Tiwari, S | 1 |
| Dong, H; Epstein, PM; Kim, EJ; Lerner, A; Tiwari, S; Weintraub, L | 1 |
| Emmerich, B; Haen, E; Hallek, M; Kamp, T; Liebl, B | 1 |
| Kim, DH; Lerner, A | 1 |
| Dalloul, AH; Mentz, F; Merle-Beral, H | 1 |
| Esselstyn, J; Hertel, C; Lee, R; Lerner, A; Moon, E; Wolda, S | 1 |
7 other study(ies) available for colforsin and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Apoptosis; Caspase 3; Caspase 9; Caspases; Cell Fractionation; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytochrome c Group; Diploidy; Enzyme Inhibitors; Flow Cytometry; Humans; Intracellular Membranes; Kinetics; Leukemia, Lymphocytic, Chronic, B-Cell; Mitochondria; Phosphoprotein Phosphatases; Protein Phosphatase 2; Rolipram; Tumor Cells, Cultured | 2003 |
Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Apoptosis; B-Lymphocytes; Benzimidazoles; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Inhibitors; Fluorescent Dyes; Guanine Nucleotide Exchange Factors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Monocytes; rap1 GTP-Binding Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; T-Lymphocytes | 2004 |
Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Apoptosis; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Synergism; Glucocorticoids; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphodiesterase Inhibitors; Response Elements; Rolipram; Transcriptional Activation | 2005 |
Defects of beta 2-adrenergic signal transduction in chronic lymphocytic leukaemia: relationship to disease progression.
Topics: Adult; Aged; Cholera Toxin; Colforsin; Cyclic AMP; Disease Progression; Female; Humans; Isoproterenol; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Male; Middle Aged; Receptors, Adrenergic, beta-2; Regression Analysis; Signal Transduction; Statistics, Nonparametric | 1997 |
Type 4 cyclic adenosine monophosphate phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Antibodies, Anti-Idiotypic; Antigens, CD19; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Bucladesine; Calcium; Calmodulin; Cells, Cultured; Colforsin; Cyclic AMP; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Interleukin-2; Isoenzymes; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Phosphodiesterase Inhibitors; Polymerase Chain Reaction; Pyrrolidinones; RNA, Messenger; Rolipram; Tumor Cells, Cultured; Tumor Stem Cell Assay; Vinca Alkaloids | 1998 |
Theophylline-induced B-CLL apoptosis is partly dependent on cyclic AMP production but independent of CD38 expression and endogenous IL-10 production.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antigens, CD; Antigens, Differentiation; Apoptosis; B-Lymphocytes; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Humans; Immunophenotyping; Interleukin-10; Leukemia, Lymphocytic, Chronic, B-Cell; Membrane Glycoproteins; NAD+ Nucleosidase; Theophylline; Thionucleotides | 1999 |
PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; B-Lymphocytes; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Humans; Intracellular Fluid; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Spleen; Theophylline; Tumor Cells, Cultured; Up-Regulation; Xanthines | 2002 |