colforsin has been researched along with Aging in 158 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (18.35) | 18.7374 |
| 1990's | 85 (53.80) | 18.2507 |
| 2000's | 32 (20.25) | 29.6817 |
| 2010's | 10 (6.33) | 24.3611 |
| 2020's | 2 (1.27) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, D; Gu, Y; Li, N; Shi, R; Tang, J; Wang, Z; Ye, Y; Yin, Y; Zhang, Y | 1 |
| Su, X; Wang, Q; Zhao, RC; Zhu, R | 1 |
| Kumar, A; Singh, N | 1 |
| Belsham, DD; Centeno, ML; Chalmers, JA; McFadden, SA; Menchella, JA | 1 |
| Bauer, I; Behmenburg, F; Heinen, A; Hollmann, MW; Huhn, R; Schmidt, A; Stracke, N; Ströthoff, M | 1 |
| Larson, ED; Proenza, C; Sharpe, EJ | 1 |
| Abrahamsson, T; Gustafsson, B; Hanse, E | 1 |
| Farrell, SR; Howlett, SE | 1 |
| Sampaio, Lde F | 1 |
| Ma, CH; Taylor, JS | 1 |
| Damle, S; Marín-García, J; Tan, T; Weiss, HR | 1 |
| Choi, BS; Ghee, JY; Han, DH; Hwang, HS; Kim, J; Piao, SG; Song, JH; Yang, CW | 1 |
| Cho, HJ; Joo, NS; Wine, JJ | 1 |
| Bauer, I; Heinen, A; Hollmann, MW; Huhn, R; Preckel, B; Schlack, W; Weber, NC | 1 |
| Belsham, DD; Chalmers, JA; Dhillon, SS; Kim, GL; Koletar, MM; Thompson, DR; Wang, X | 1 |
| Baamonde, C; Dierssen, M; Flórez, J; Lumbreras, MA; MartInez-Cué, C; Vallina, IF | 1 |
| Cousins, MM; Seidler, FJ; Slikker, W; Slotkin, TA; Xu, Z | 1 |
| Armbrecht, HJ; Boltz, MA; Hodam, TL | 1 |
| Hrbasová, M; Kolár, F; Novotny, J; Svoboda, P | 1 |
| Asai, K; Kudej, RK; Natividad, F; Peppas, A; Resuello, RR; Rossi, F; Shen, YT; Takagi, G; Takagi, I; Vatner, DE; Vatner, SF | 1 |
| Cousins, MM; Seidler, FJ; Slotkin, TA; Tate, CA | 1 |
| Huang, AS; Lee, MB; Parfitt, KD; Reis, GF | 1 |
| Novotny, J; Stöhr, J; Svoboda, P | 1 |
| Kau, MM; Lo, MJ; Wang, PS | 1 |
| Joyner, RW; Namiki, T; Wagner, MB | 1 |
| Delp, MD; Donato, AJ; Lesniewski, LA | 1 |
| Li, B; Schild, JH | 1 |
| Burns, KA; Grubb, BR; Kulaga, HM; Ostrowski, LE; Reed, RR; Rogers, TD; Wonsetler, RL | 1 |
| Cacicedo, L; Frutos, MG; González, M; Méndez, CF; Sánchez-Franco, F; Vicent, D | 1 |
| Abrass, IB; Scarpace, PJ | 2 |
| Makihata, J; Nomura, Y; Segawa, T | 1 |
| Klausa, G; Rörig, B; Sutor, B | 1 |
| Amano, I; Chen, C; Eguchi, T; Ishida, H; Ishikawa, Y | 1 |
| Scarpace, PJ; Shu, Y | 1 |
| Davies, AR; Howl, J; Hughes, PJ; Kirk, CJ; Lavis, RA; Michell, RH; Parslow, RA; Rudge, SA; Wheatley, M | 1 |
| Lefebvre, RA; Smits, GJ | 1 |
| Akita, T; Joyner, RW; Kumar, R | 2 |
| Brodde, OE; Broede-Sitz, A; Michel-Reher, M; Oelert, H; Piotrowski, JA; Schäfer-Beisenbusch, E; Schranz, D; Zerkowski, HR | 1 |
| Stewart, HJ | 1 |
| Collins, BJ; Cuttler, L; Marone, PA; Szabo, M | 1 |
| Mulderry, PK | 1 |
| Higami, Y; Ikeda, T; Okimoto, T; Shimokawa, I | 1 |
| Latifpour, J; Nishimoto, T; Weiss, RM; Wheeler, MA; Yoshida, M | 1 |
| Bischoff, A; Farke, W; Feth, F; Lewejohann, K; Michel, MC; Rascher, W | 1 |
| Araki, T; Kanai, Y; Kato, H; Kogure, K | 1 |
| Aguila-Mansilla, N; Kedzierski, W; Porter, JC | 1 |
| Dobber, R; Nagelkerken, L; Schuitemaker, J; Tielemans, M; van den Bergh, P | 1 |
| Gong, L; Kostrzewa, RM; Li, C | 1 |
| Aizawa, T; Hashizume, K; Ishihara, F; Komatsu, M; Nishii, N; Sato, Y; Suzuki, N; Yamada, T | 1 |
| Dekel, N; Goren, S; Piontkewitz, Y | 1 |
| Scarpace, PJ; Shu, Y; Tümer, N | 1 |
| Conte Camerino, D; De Luca, A; Pierno, S | 1 |
| Baker, SR; Goldsworthy, J; Johnson, BG; Salhoff, CR; Schoepp, DD | 1 |
| Conte Camerino, D; De Luca, A; Pierno, S; Tricarico, D | 1 |
| Rajakumar, G; Scarpace, PJ | 2 |
| Klein, DC; White, BH | 1 |
| Felder, RA; Hendley, ED; Ohbu, K; Yamaguchi, I | 1 |
| Cavallin, S; Sato, F; Sato, K; Sato, KT | 1 |
| Eiffert, KC; Horwitz, BA; Larkin, LM; McDonald, RB | 1 |
| Dobson, SP; Morrow, JA; Mulderry, PK; Quinn, JP | 1 |
| McCook, EC; Seidler, FJ; Slotkin, TA | 1 |
| Joyner, RW; Kumar, R; Osaka, T | 1 |
| Araki, T; Ishida, Y; Kanai, Y; Kato, H; Kogure, K; Shuto, K | 1 |
| May, T; Sugawa, M | 1 |
| Matheny, M; Scarpace, PJ | 1 |
| Ball, JM; Estes, MK; Morris, AP; Tian, P; Zeng, CQ | 1 |
| Suzuki, K; Yamada, H | 1 |
| Araki, T; Fujiwara, T; Itoyama, Y; Kato, H | 1 |
| Katsube, Y; Nguyen, L; Sperelakis, N; Yokoshiki, H | 1 |
| Jensen, AM; Wallace, VA | 1 |
| Belagaje, R; Burnett, JP; Johnson, BG; Mayne, NG; Monn, JA; Salhoff, CR; Schoepp, DD; Wright, RA; Wu, S | 1 |
| Kobayashi, T; Ohnishi, A; Satake, M; Yoshimura, T | 1 |
| Bowman, CJ; Kelley, A; LaRochelle, JS; Scarpace, PJ; Tümer, N | 1 |
| Bickford, PC; Gould, TJ | 1 |
| Defer, N; Hanoune, J; Miyamoto, N; Poyard, M; Shen, T; Suzuki, Y | 1 |
| Donahue, HJ; Li, Z; McCauley, LK; Zhou, Z | 1 |
| Delacourt, C; Delclaux, C; Harf, A; L'Hour, J; Lafuma, C; Rouet-Benzineb, P | 1 |
| Noguchi, K; Shigenobu, K; Tanaka, H | 1 |
| Dumas, TC; Foster, TC | 1 |
| Boluyt, MO; Cheng, H; Ji, X; Koch, WJ; Lakatta, EG; Tomhave, ED; Wang, DJ; Xiao, RP | 1 |
| McCook, EC; Seidler, FJ; Slotkin, TA; Zhang, J | 1 |
| Brodde, OE; Giessler, C; Wangemann, T; Zerkowski, HR | 1 |
| Matheny, M; Scarpace, PJ; Tümer, N | 1 |
| Chen, JJ; Kau, MM; Lin, H; Lo, MJ; Wang, PS; Wang, SW; Yeh, JY | 1 |
| Chapman, J; Mader, SL; Schutzer, WE; Watts, VJ | 1 |
| Fex Svenningsen, A; Kanje, M | 1 |
| Abe, I; Fujii, K; Fujishima, M; Goto, K; Onaka, U | 1 |
| Antonaci, S; Jirillo, E; Piazzolla, G; Spaccavento, F; Tortorella, C | 1 |
| Friedman, E; Gao, E; Gao, F; Horwitz, J; Ma, XL; Pelleg, A; Snyder, DL; Xu, J | 1 |
| Kirk, CJ; Miller, RA | 1 |
| Hayabuchi, Y; Kuroda, Y; Mori, K; Moritoki, H; Nakaya, Y; Tsuchiya, K | 1 |
| Bogdanovic, N; Cowburn, RF; Fastbom, J; García-Jiménez, A; Ohm, TG; Winblad, B | 1 |
| Seidler, FJ; Slotkin, TA; Zeiders, JL | 1 |
| Després, JP; Imbeault, P; Mauriège, P; Prud'Homme, D; Tremblay, A | 1 |
| Derweesh, IH; Weiss, RM; Wheeler, MA | 1 |
| Enjalbert, A; Gautron, JP; Rochdi, L; Théraulaz, L | 1 |
| Chow, FA; McCook, EC; Seidler, FJ; Slotkin, TA | 1 |
| Anderson, S; Mader, SL; Reed, JF; Roullet, JB; Schutzer, WE; Xue, H | 1 |
| Després, JP; Imbeault, P; Mauriège, P; Nadeau, A; Tremblay, A; Vega, N; Vidal, H | 1 |
| Gibbs, CL; Kiriazis, H | 1 |
| Kao, C; Rowlands, DK; Wise, H | 1 |
| Lopez, M; Mazzeo, RS; Podolin, DA; Roth, DA; Wills, BK; Wood, IO | 1 |
| Aghajanian, GK; Akbarian, S; Bates, B; Bothwell, M; Coppola, V; Fan, G; Jaenisch, R; Kosofsky, BE; Kucera, J; Liu, RJ; Nestler, EJ; Pejchal, T; Skirboll, SL; Sun, LD; Taylor, JR; Tessarollo, L; Wilson, MA | 1 |
| Liu, J; Olivier, K; Pope, C | 1 |
| Andersen, SL | 1 |
| Lo, MJ; Wang, PS | 1 |
| Chen, CF; Chiou, WF | 1 |
| Dénéréaz, N; Lemarchand-Béraud, T; Reymond, F | 1 |
| Mader, SL | 1 |
| Borst, SE; Crass, MF; Scarpace, PJ | 1 |
| Casabona, G; Di Stefano, M; Genazzani, AA; Nicoletti, F; Sortino, MA | 1 |
| Del Monte, F; Harding, SE; Jones, SM; Poole-Wilson, PA; Vescovo, G | 1 |
| Hultgardh-Nilsson, A; Jonzon, B; Nilsson, J; Querol-Ferrer, V; Ringertz, NR | 1 |
| Costa, PF; Ribeiro, MA; Santos, AI | 1 |
| Alafuzoff, I; Cowburn, RF; Fowler, CJ; O'Neill, C; Ravid, R; Winblad, B | 1 |
| Cain, ST; Nemeroff, CB; Pihoker, C | 1 |
| Chin, JH; Hoffman, BB | 2 |
| Kishi, M; Kuriyama, K; Ma, FH; Ohkuma, S | 1 |
| Atkinson, BN; Minneman, KP | 1 |
| Kavlock, RJ; Kudlacz, EM; Navarro, HA; Slotkin, TA | 2 |
| Buja, LM; DeBeltz, D; Muntz, KH; Shaul, PW | 1 |
| Enero, MA; Kazanietz, MG | 1 |
| Johnstone, AP; Nussey, SS; Page, SR; Taylor, AH; Whitley, GS | 1 |
| Billiau, A; Carmeliet, P; Denef, C; Van Damme, J; Vankelecom, H | 1 |
| Shigenobu, K; Tanaka, H | 1 |
| Lemmer, B; Wald, C | 1 |
| Scarpace, PJ | 1 |
| Hoffman, BB; Lee, CH; Tsujimoto, G | 1 |
| Cheng, L; Hanai, H; Liang, CT; Sacktor, B | 1 |
| Deisher, TA; Hoffman, BB; Mankani, S | 1 |
| Danziger, RS; Hansford, RG; Lakatta, EG; Sakai, M; Staddon, JM | 1 |
| Batson, JM; Evans, WS; Krieg, RJ; Martha, PM; Rogol, AD | 1 |
| Boland, SR; Hymer, TK; Katz, MS; McNair, CL | 1 |
| Chang, H; Hoffman, BB; Reaven, GM | 1 |
| Heindel, JJ | 1 |
| Mooradian, AD; Morley, JE; Scarpace, PJ | 1 |
| McCarthy, L; McMahon, KK; Schimmel, RJ | 1 |
| Hartter, DE; Ramirez, VD | 1 |
| Connelly-Fittingoff, M; Fernandez, EI; Krall, JF | 2 |
| Hanai, H; Ishida, M; Liang, CT; Sacktor, B | 1 |
| Butturini, U; Ceda, GP; Hoffman, AR; Valenti, G | 1 |
| Kawai, M; Kitamura, Y; Nomura, Y; Segawa, T | 1 |
| Kimura, A; Nakagawa, H; Ohuchi, T; Oka, M | 1 |
| Dax, EM; Gregerman, RI; Partilla, JS; Piñeyro, MA | 1 |
| Armbrecht, HJ; Boltz, MA; Forte, LR | 1 |
| Scarpace, PJ; Yu, BP | 1 |
| Camus, JC; Christophe, J; De Neef, P; Gillard, M; Robberecht, P; Waelbroeck, M | 2 |
| Mader, SL; Robbins, AS; Rubenstein, LZ; Scarpace, PJ; Tuck, ML | 1 |
| Artman, M; Kithas, PA; Strada, SJ; Wike, JS | 1 |
| Arima, T; Nomura, Y; Swgawa, T | 1 |
| Cho, YH; Housman, A; Weiss, RM; Wheeler, MA | 1 |
2 trial(s) available for colforsin and Aging
| Article | Year |
|---|---|
Age-dependent changes in the beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in human right atrium.
Topics: Adenylyl Cyclases; Adolescent; Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Aging; Blotting, Western; Child; Child, Preschool; Colforsin; Female; GTP-Binding Proteins; Heart Atria; Humans; Infant; Infant, Newborn; Isoproterenol; Male; Middle Aged; Myocardial Contraction; Receptors, Adrenergic, beta; Terbutaline | 1995 |
Adipose tissue metabolism in young and middle-aged men after control for total body fatness.
Topics: Adipose Tissue; Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Agonists; Adult; Aging; Body Composition; Brimonidine Tartrate; Bucladesine; Cell Separation; Colforsin; Epinephrine; Glycerol; Humans; Isoproterenol; Lipolysis; Lipoprotein Lipase; Male; Middle Aged; Quinoxalines; Theophylline | 2000 |
156 other study(ies) available for colforsin and Aging
| Article | Year |
|---|---|
Aging-Induced Down-Regulation of PKA/BKCa Pathway in Rat Cerebral Arteries.
Topics: Aging; Animals; Cerebral Arteries; Colforsin; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Male; Rats; Rats, Sprague-Dawley | 2022 |
cAMP Agonist Forskolin Disrupts Mitochondrial Metabolism and Induces Senescence in Human Mesenchymal Cells.
Topics: Adult; Aging; Cell Cycle Checkpoints; Cell Proliferation; Cells, Cultured; Cellular Senescence; Colforsin; Humans | 2023 |
Calcineurin Inhibition and Protein Kinase A Activation Limits Cognitive Dysfunction and Histopathological Damage in a Model of Dementia of the Alzheimer's Type.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Brain; Calcineurin; Calcineurin Inhibitors; Cholinesterase Inhibitors; Cognition Disorders; Colforsin; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Donepezil; Drug Therapy, Combination; Female; Glutathione; Male; Maze Learning; Mice; Peroxidase; Streptozocin; Tacrolimus; Thiobarbituric Acid Reactive Substances; Vasodilator Agents | 2018 |
Glucose responsiveness in a novel adult-derived GnRH cell line, mHypoA-GnRH/GFP: involvement of AMP-activated protein kinase.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Glucose; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; Mice; Models, Biological; Neurons; Nitric Oxide; Peptides; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; RNA, Messenger; Second Messenger Systems; Signal Transduction; Tetradecanoylphorbol Acetate | 2013 |
Pharmacological options to protect the aged heart from ischemia and reperfusion injury by targeting the PKA-BK(Ca) signaling pathway.
Topics: Age Factors; Aging; Animals; Benzimidazoles; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Large-Conductance Calcium-Activated Potassium Channels; Male; Molecular Targeted Therapy; Myocardial Reperfusion Injury; Myocardium; Potassium Channel Blockers; Rats, Wistar; Signal Transduction | 2014 |
Cyclic AMP reverses the effects of aging on pacemaker activity and If in sinoatrial node myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Aging; Animals; Cardiotonic Agents; Cells, Cultured; Colforsin; Cyclic AMP; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Sinoatrial Node | 2017 |
AMPA silencing is a prerequisite for developmental long-term potentiation in the hippocampal CA1 region.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Animals, Newborn; Colforsin; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Models, Biological; Rats; Valine; Xanthenes | 2008 |
The age-related decrease in catecholamine sensitivity is mediated by beta(1)-adrenergic receptors linked to a decrease in adenylate cyclase activity in ventricular myocytes from male Fischer 344 rats.
Topics: Adenylyl Cyclases; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Agonists; Aging; Albuterol; Animals; Bucladesine; Calcium Signaling; Catecholamines; Colforsin; Cyclic AMP; Dobutamine; Electric Stimulation; In Vitro Techniques; Male; Myocardial Contraction; Myocytes, Cardiac; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta-1 | 2008 |
An unexpected effect of 5-MCA-NAT in chick retinal development.
Topics: Aging; Animals; Binding Sites; Chick Embryo; Chickens; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Melatonin; Neurogenesis; Neurons; Organ Culture Techniques; Organogenesis; Quinone Reductases; Receptors, G-Protein-Coupled; Receptors, Melatonin; Retina; Second Messenger Systems; Tryptamines; Up-Regulation | 2009 |
Trophic responsiveness of purified postnatal and adult rat retinal ganglion cells.
Topics: Age Factors; Aging; Animals; Cell Growth Processes; Cell Separation; Cells, Cultured; Ciliary Neurotrophic Factor; Colforsin; Culture Media, Conditioned; Mitogen-Activated Protein Kinase 3; Neurites; Rats; Retinal Ganglion Cells; Schwann Cells; Signal Transduction | 2010 |
Hypoxia-inducible factor-1 improves inotropic responses of cardiac myocytes in ageing heart without affecting mitochondrial activity.
Topics: Aging; Animals; Calcium; Ciclopirox; Colforsin; Electron Transport Complex I; Electron Transport Complex III; Hypoxia-Inducible Factor 1, alpha Subunit; Mitochondria, Heart; Myocardial Contraction; Myocytes, Cardiac; Ouabain; Pyridones; Rats; Rats, Inbred F344; Reactive Oxygen Species | 2010 |
Effect of sirolimus on calcineurin inhibitor-induced nephrotoxicity using renal expression of KLOTHO, an antiaging gene.
Topics: Aging; Animals; Calcineurin Inhibitors; Colforsin; Cyclosporine; DNA Primers; Fibroblast Growth Factor-23; Gene Expression Regulation; Glucuronidase; Immunosuppressive Agents; Kidney; Klotho Proteins; Mice; Nephritis, Interstitial; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Sirolimus; Tacrolimus | 2010 |
Defective fluid secretion from submucosal glands of nasal turbinates from CFTR-/- and CFTR (ΔF508/ΔF508) pigs.
Topics: Aging; Animals; Animals, Newborn; Body Fluids; Carbachol; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Synergism; Exocrine Glands; Mutation; Organ Size; Substance P; Sus scrofa; Trachea; Turbinates | 2011 |
Age-related loss of cardiac preconditioning: impact of protein kinase A.
Topics: Aging; Animals; Calcium-Binding Proteins; Colforsin; CREB-Binding Protein; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Helium; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphorylation; Rats; Rats, Wistar | 2012 |
Generation of immortal cell lines from the adult pituitary: role of cAMP on differentiation of SOX2-expressing progenitor cells to mature gonadotropes.
Topics: Aging; Animals; Biomarkers; Cell Culture Techniques; Cell Differentiation; Cell Line, Transformed; Colforsin; Culture Media, Serum-Free; Cyclic AMP; Follicle Stimulating Hormone, beta Subunit; Gene Expression Regulation; Glycoprotein Hormones, alpha Subunit; Gonadotrophs; Luteinizing Hormone; Mice; Mice, Inbred C57BL; Pituitary Gland; RNA, Messenger; SOXB1 Transcription Factors; Stem Cells | 2011 |
Postnatal handling induces long-term modifications in central beta-noradrenergic signalling in rats.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Aging; Animals; Animals, Newborn; Cerebellum; Cerebral Cortex; Colforsin; Cyclic AMP; Female; Handling, Psychological; Hippocampus; Isoproterenol; Norepinephrine; Phosphodiesterase Inhibitors; Pregnancy; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Signal Transduction | 2002 |
Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Aging; Animals; Brain Chemistry; Colforsin; Female; GTP-Binding Proteins; Isoproterenol; Male; Nicotine; Nicotinic Agonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Signal Transduction; Substance Withdrawal Syndrome; Up-Regulation | 2002 |
PTH increases renal 25(OH)D3-1alpha -hydroxylase (CYP1alpha) mRNA but not renal 1,25(OH)2D3 production in adult rats.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Aging; Animals; Calcium, Dietary; Colforsin; Dose-Response Relationship, Drug; In Vitro Techniques; Kidney; Male; Parathyroid Hormone; Parathyroidectomy; Rats; Rats, Inbred F344; RNA, Messenger | 2003 |
Cardiomegaly induced by pressure overload in newborn rats is accompanied by altered expression of the long isoform of G(s)alpha protein and deranged signaling of adenylyl cyclase.
Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Cardiomegaly; Cardiotonic Agents; Colforsin; Fluorides; Gene Expression; GTP-Binding Proteins; Hypertrophy, Left Ventricular; Isoproterenol; Manganese; Myocardium; Pressure; Protein Isoforms; Rats; Rats, Wistar; Signal Transduction | 2003 |
Gender differences on the effects of aging on cardiac and peripheral adrenergic stimulation in old conscious monkeys.
Topics: Aging; Animals; Colforsin; Consciousness; Dihydropyridines; Female; Isoproterenol; Macaca fascicularis; Male; Norepinephrine; Ovary; Receptors, Adrenergic, beta; Sex Characteristics; Sympathetic Nervous System; Sympathomimetics | 2003 |
Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats.
Topics: Adaptation, Physiological; Adenylyl Cyclases; Aging; Animals; Colforsin; Depression; GTP-Binding Proteins; Male; Manganese; Neurotransmitter Agents; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin; Signal Transduction; Stimulation, Chemical | 2005 |
Adenylate cyclase-mediated forms of neuronal plasticity in hippocampal area CA1 are reduced with aging.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Age Factors; Aging; Analysis of Variance; Animals; Colforsin; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Enzyme Activation; Hippocampus; Isoproterenol; Long-Term Potentiation; Male; Neuronal Plasticity; Neurons; Rats; Rats, Inbred F344; Time Factors | 2005 |
Characterization of [3H]-forskolin binding sites in young and adult rat brain cortex: identification of suramin as a competitive inhibitor of [3H]-forskolin binding.
Topics: Adrenergic beta-Agonists; Aging; Animals; Baclofen; Binding, Competitive; Cell Membrane; Cerebral Cortex; Colforsin; GABA Agonists; Guanylyl Imidodiphosphate; Isoproterenol; Magnesium; Male; Rats; Rats, Wistar; Receptors, Drug; Suramin | 2005 |
Effect of aging on corticosterone secretion in diestrous rats.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Aging; Animals; Colforsin; Corticosterone; Cyclic AMP; Diestrus; Estradiol; Female; Progesterone; Prolactin; Rats; Rats, Sprague-Dawley; Signal Transduction | 2006 |
Developmental changes in time course of recovery from inactivation in L-type calcium currents of rabbit ventricular myocytes.
Topics: Aging; Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Colforsin; Heart Ventricles; Ion Channel Gating; Kinetics; Myocytes, Cardiac; Rabbits; Time Factors; Ventricular Function | 2007 |
Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles.
Topics: Adrenergic beta-Agonists; Aging; Animals; Arterioles; Colforsin; Enzyme Inhibitors; Hindlimb; Isoproterenol; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2007 |
Persistent tetrodotoxin-resistant Na+ currents are activated by prostaglandin E2 via cyclic AMP-dependent pathway in C-type nodose neurons of adult rats.
Topics: Aging; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Electrophysiology; Ion Channel Gating; Male; Neurons; Nodose Ganglion; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium; Tetrodotoxin; Up-Regulation | 2007 |
Olfactory epithelia exhibit progressive functional and morphological defects in CF mice.
Topics: Acetophenones; Adenylyl Cyclases; Aging; Aldehydes; Amiloride; Animals; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activators; Mice; Mice, Inbred CFTR; Microscopy, Electron, Scanning; Odorants; Olfactory Mucosa; Olfactory Receptor Neurons; Pentanols; Receptors, Odorant; RNA, Messenger; Smell; Sodium; Sodium Channel Blockers; Time Factors; Tissue Culture Techniques | 2007 |
Pituitary alterations involved in the decline of growth hormone gene expression in the pituitary of aging rats.
Topics: Aging; Animals; Cells, Cultured; Colforsin; Cyclic AMP Response Element-Binding Protein; Gene Expression; Ghrelin; Growth Hormone; Growth Hormone-Releasing Hormone; Insulin-Like Growth Factor I; Male; Peptide Hormones; Pituitary Gland; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Ghrelin; Receptors, Neuropeptide; Receptors, Pituitary Hormone-Regulating Hormone; Receptors, Somatostatin; RNA, Messenger; Transcription Factor Pit-1 | 2007 |
Decreased beta-adrenergic agonist affinity and adenylate cyclase activity in senescent rat lung.
Topics: Adenylyl Cyclases; Aging; Animals; Binding, Competitive; Colforsin; Dihydroalprenolol; Diterpenes; Female; Guanylyl Imidodiphosphate; Isoproterenol; Lung; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta; Temperature | 1983 |
Activation of adenylate cyclase by dopamine, GTP, NaF and forskolin in striatal membranes of neonatal, adult and senescent rats.
Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Colforsin; Corpus Striatum; Diterpenes; Dopamine; Enzyme Activation; Female; Guanosine Triphosphate; In Vitro Techniques; Male; Membranes; Rats; Rats, Inbred Strains; Sodium Fluoride | 1984 |
Catalytic unit of adenylate cyclase: reduced activity in aged-human lymphocytes.
Topics: Adenylyl Cyclases; Adult; Aged; Aging; Colforsin; Diterpenes; Enzyme Activation; Guanosine Triphosphate; Humans; Isoproterenol; Lymphocytes; Male; Sodium Fluoride | 1982 |
Dye coupling between pyramidal neurons in developing rat prefrontal and frontal cortex is reduced by protein kinase A activation and dopamine.
Topics: Aging; Animals; Animals, Newborn; Colforsin; Coloring Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Electric Impedance; Enzyme Activation; Enzyme Inhibitors; Female; Frontal Lobe; Gap Junctions; In Vitro Techniques; Male; Membrane Potentials; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Wistar; Thionucleotides | 1995 |
Age-dependent changes in response of rat prostatic tissues to isoproterenol and forskolin: changes with sexual maturation in function of G proteins.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Adrenergic beta-Agonists; Aging; Animals; Cell Nucleus; Colforsin; GTP-Binding Proteins; Isoproterenol; Male; Prostate; Rats; Rats, Wistar; Sexual Maturation; Signal Transduction; Testosterone | 1995 |
Forskolin binding sites and G-protein immunoreactivity in rat hearts during aging.
Topics: Adenylyl Cyclases; Aging; Animals; Binding Sites; Colforsin; Dose-Response Relationship, Drug; GTP-Binding Proteins; Heart; Male; Membranes; Myocardium; Rats; Rats, Inbred F344; Sodium Fluoride | 1994 |
Rat testicular myoid cells express vasopressin receptors: receptor structure, signal transduction, and developmental regulation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Aging; Amino Acid Sequence; Animals; Arginine Vasopressin; Base Sequence; Blotting, Northern; Cells, Cultured; Cloning, Molecular; Colforsin; Consensus Sequence; Cyclic AMP; DNA Primers; Gene Expression Regulation; Inositol Phosphates; Male; Molecular Sequence Data; Muscle, Smooth; Phosphoric Diester Hydrolases; Rats; Rats, Wistar; Receptors, Vasopressin; Seminiferous Tubules; Sequence Homology, Amino Acid; Sexual Maturation; Signal Transduction; Testis | 1995 |
Influence of age on the signal transduction pathway of non-adrenergic non-cholinergic neurotransmitters in the rat gastric fundus.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Electric Stimulation; Gastric Fundus; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Rats; Rats, Wistar; Signal Transduction; Vasoactive Intestinal Peptide | 1995 |
Developmental changes in modulation of contractility of rabbit hearts.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Blood Pressure; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Heart Ventricles; Isoproterenol; Myocardial Contraction; Phosphodiesterase Inhibitors; Rabbits; Receptors, Adrenergic, beta; Signal Transduction; Ventricular Function, Left | 1995 |
Expression of c-Jun, Jun B, Jun D and cAMP response element binding protein by Schwann cells and their precursors in vivo and in vitro.
Topics: Aging; Animals; Axons; Cell Communication; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Denervation; Nerve Crush; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve; Stem Cells | 1995 |
The effect of isobutylmethylxanthine, forskolin, and cholera toxin on growth hormone release from pituitary cell cultures of perinatal and mature rats.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Cells, Cultured; Cholera Toxin; Colforsin; Dose-Response Relationship, Drug; Female; Fetus; Growth Hormone; Male; Pituitary Gland; Rats; Rats, Sprague-Dawley | 1993 |
Synergistic regulation of vasoactive intestinal polypeptide expression by cyclic AMP and calcium in newborn but not adult rat sensory neurons in culture.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Aging; Animals; Animals, Newborn; Axons; Calcitonin Gene-Related Peptide; Calcium; Colforsin; Cyclic AMP; Female; Ganglia, Spinal; Immunohistochemistry; Male; Nerve Growth Factors; Neurons, Afferent; Rats; Rats, Wistar; Signal Transduction; Substance P; Vasoactive Intestinal Peptide | 1993 |
The growth hormone-releasing hormone-cyclic adenosine-3',5'-monophosphate signal pathway in somatotropes is practically intact during aging.
Topics: Aging; Animals; Cell Separation; Colforsin; Cyclic AMP; Growth Hormone; Growth Hormone-Releasing Hormone; Hemolytic Plaque Technique; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred F344; Signal Transduction; Specific Pathogen-Free Organisms | 1994 |
Age-dependent alterations in beta-adrenergic responsiveness of rat detrusor smooth muscle.
Topics: Aging; Animals; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP; Electric Stimulation; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Potassium Chloride; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta; Urinary Bladder | 1995 |
Regulation of NPY/NPY Y1 receptor/G protein system in rat brain cortex.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Aging; Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Colforsin; Female; GTP-Binding Proteins; Homeostasis; Inositol Phosphates; Kinetics; Male; NAD; Neuropeptide Y; Norepinephrine; Pertussis Toxin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Neuropeptide Y; Sex Characteristics; Species Specificity; Virulence Factors, Bordetella | 1995 |
Age-dependent changes in second messenger and rolipram receptor systems in the gerbil brain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Aging; Animals; Autoradiography; Brain; Brain Chemistry; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gerbillinae; Inositol 1,4,5-Trisphosphate; Male; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptors, Drug; Rolipram; Second Messenger Systems | 1994 |
Localization of a defect in hypothalamic dopaminergic neurons of the aged brain that results in impaired PKA-dependent activation of tyrosine hydroxylase.
Topics: Aging; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enzyme Activation; Female; Hypothalamus; Ovariectomy; Rats; Receptors, Vasoactive Intestinal Peptide; Signal Transduction; Theophylline; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1993 |
The sensitivity of IL-4 production for cAMP inducers is lost in CD4+ T cells from aged mice.
Topics: Aging; Animals; Antigen-Presenting Cells; CD4-Positive T-Lymphocytes; Cells, Cultured; Colforsin; Concanavalin A; Cyclic AMP; Dinoprostone; Enzyme Induction; Immunophenotyping; Interleukin-2; Interleukin-4; Lymphocyte Activation; Male; Mice; Mice, Inbred CBA | 1993 |
Neonatal 6-hydroxydopamine and adult SKF 38393 treatments alter dopamine D1 receptor mRNA levels: absence of other neurochemical associations with the enhanced behavioral responses of lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Benzazepines; Binding, Competitive; Brain; Cerebral Ventricles; Colforsin; Corpus Striatum; Dopamine; Gene Expression; Injections, Intraventricular; Motor Activity; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Serotonin; RNA, Messenger; Sodium Fluoride | 1994 |
Insulin secretion by the pancreatic beta cell of aged rats.
Topics: Aging; Animals; Colforsin; Dose-Response Relationship, Drug; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nifedipine; Potassium; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1994 |
Meiotic arrest in incompetent rat oocytes is not regulated by cAMP.
Topics: Aging; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cells, Cultured; Colforsin; Cyclic AMP; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Homeostasis; Immune Sera; Luteinizing Hormone; Meiosis; Molecular Sequence Data; Oocytes; Ovarian Follicle; Peptides; Rats; Rats, Wistar; Sexual Maturation | 1994 |
Influence of exercise training on myocardial beta-adrenergic signal transduction: differential regulation with age.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Enzyme Activation; Female; GTP-Binding Proteins; Heart; Isoproterenol; Myocardium; Organ Size; Oxygen Consumption; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta; Signal Transduction | 1994 |
Pharmacological interventions for the changes of chloride channel conductance of aging rat skeletal muscle.
Topics: Aging; Animals; Chloride Channels; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Female; Growth Hormone; Male; Muscles; Rats; Rats, Inbred WKY; Rats, Wistar; Taurine | 1994 |
3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus.
Topics: Aging; Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Colforsin; Cyclic AMP; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Kinetics; Male; Neurotoxins; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Resorcinols; Second Messenger Systems | 1994 |
Aging and chloride channel regulation in rat fast-twitch muscle fibres.
Topics: Aging; Animals; Calcimycin; Chloride Channels; Chlorides; Cholera Toxin; Colforsin; Electric Conductivity; Male; Muscle Contraction; Muscles; Phorbol 12,13-Dibutyrate; Potassium; Rats; Rats, Wistar; Time Factors; Toes; Virulence Factors, Bordetella | 1994 |
Relationship between cAMP production and protein secretion in rat submandibular acini: evidence for loss of reserve capacity with age.
Topics: Aging; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; In Vitro Techniques; Isoproterenol; Male; Rats; Rats, Inbred F344; Reference Values; Salivary Proteins and Peptides; Submandibular Gland | 1994 |
Developmental appearance of pineal adrenergic-->guanosine 3',5'-monophosphate response is determined by a process down-stream from elevation of intracellular Ca2+: possible involvement of a diffusible factor.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adrenal Glands; Aging; Animals; Arachidonic Acid; Calcium; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Cytosol; Guanylate Cyclase; Isoproterenol; Kinetics; Mice; Norepinephrine; Organ Culture Techniques; Phospholipases A; Phospholipases A2; Pineal Gland; Potassium; Protein Kinases; Rats; Tetradecanoylphorbol Acetate | 1993 |
Renal dopamine-1 receptors in hypertensive inbred rat strains with and without hyperactivity.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Benzazepines; Blood Pressure; Colforsin; Dopamine Agents; Fenoldopam; Guanylyl Imidodiphosphate; Hypertension; Iodine Radioisotopes; Kidney; Kidney Cortex; Kidney Tubules, Collecting; Kidney Tubules, Proximal; Kinetics; Male; Motor Activity; Nephrons; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Dopamine D1; Sodium | 1993 |
Secretion of ions and pharmacological responsiveness in the mouse paw sweat gland.
Topics: Aging; Animals; Colforsin; Culture Techniques; Cyclic AMP; Eccrine Glands; Forelimb; Isoproterenol; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Potassium; Sodium | 1994 |
Adrenergic stimulated skeletal muscle glycogenolysis in perfused hindlimbs of young and old male Fischer 344 rats.
Topics: Aging; Animals; Colforsin; Epinephrine; Glycogen; Hindlimb; Male; Muscles; Osmolar Concentration; Oxygen Consumption; Perfusion; Rats; Rats, Inbred F344 | 1994 |
The rat vasoactive intestinal polypeptide cyclic AMP response element regulates gene transcriptional responses differently in neonatal and adult rat sensory neurons.
Topics: Aging; Animals; Animals, Newborn; Base Sequence; Chloramphenicol O-Acetyltransferase; Colforsin; Cyclic AMP Response Element-Binding Protein; Electrophysiology; Genes, Reporter; Molecular Sequence Data; Neurons, Afferent; Oligonucleotide Probes; Potassium; Rats; Transcription, Genetic; Vasoactive Intestinal Peptide | 1994 |
Glucocorticoids regulate the development of intracellular signaling: enhanced forebrain adenylate cyclase catalytic subunit activity after fetal dexamethasone exposure.
Topics: Adenylyl Cyclases; Aging; Analysis of Variance; Animals; Body Weight; Colforsin; Dexamethasone; Female; Fluorides; Gestational Age; GTP-Binding Proteins; Guanosine Triphosphate; Macromolecular Substances; Maternal-Fetal Exchange; Membrane Proteins; Pregnancy; Prosencephalon; Rats; Rats, Sprague-Dawley; Weight Gain | 1993 |
Postnatal decrease in muscarinic cholinergic influence on Ca2+ currents of rabbit ventricular cells.
Topics: Adenylate Cyclase Toxin; Aging; Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Carbachol; Colforsin; Electric Conductivity; Female; Guanylyl Imidodiphosphate; Heart Ventricles; Isoproterenol; Male; Myocardium; Pertussis Toxin; Rabbits; Receptors, Muscarinic; Virulence Factors, Bordetella | 1993 |
Effect of vinconate against regional age-related changes in the gerbil brain.
Topics: Acetylcholine; Aging; Animals; Autoradiography; Brain; Brain Chemistry; Colforsin; Cyclic AMP; Gerbillinae; Isradipine; Male; Quinuclidinyl Benzilate; Receptors, Muscarinic; Vinca Alkaloids | 1993 |
Age-related alteration in signal transduction: involvement of the cAMP cascade.
Topics: Adenylyl Cyclases; Aging; Animals; Basal Metabolism; Colforsin; Corpus Striatum; Cyclic AMP; Female; Nucleus Accumbens; Radioligand Assay; Rats; Rats, Wistar; Signal Transduction | 1993 |
Thermogenesis in brown adipose tissue with age: post-receptor activation by forskolin.
Topics: Adipose Tissue, Brown; Adrenergic beta-Antagonists; Aging; Animals; Binding Sites; Body Temperature Regulation; Carrier Proteins; Colforsin; Guanosine Diphosphate; Ion Channels; Male; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Oxygen Consumption; Propanolamines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; RNA, Messenger; Uncoupling Agents; Uncoupling Protein 1 | 1996 |
Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein.
Topics: Aging; Amino Acid Sequence; Animals; Calcium; Carbachol; Chlorides; Colforsin; Diarrhea; Enterotoxins; Glycoproteins; Immune Sera; Immunization; In Vitro Techniques; Intestinal Mucosa; Mice; Molecular Sequence Data; Peptide Fragments; Receptors, Virus; Rotavirus; Rotavirus Infections; Signal Transduction; Toxins, Biological; Viral Nonstructural Proteins | 1996 |
Adenosine and carbachol are not equivalent in their effects on L-type calcium current in rabbit ventricular cells.
Topics: Adenosine; Aging; Amino Acid Sequence; Animals; Animals, Newborn; Calcium Channels; Carbachol; Colforsin; Cyclic AMP; Heart Ventricles; Isoproterenol; Male; Molecular Sequence Data; Rabbits; Stimulation, Chemical; Therapeutic Equivalency | 1996 |
Age-related differences in mouse Schwann cell response to cyclic AMP.
Topics: Aging; Animals; Biomarkers; Cell Division; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Galactosylceramides; Mice; Mice, Inbred C57BL; Mitogens; Schwann Cells | 1996 |
Age-related changes in bindings of second messengers in the rat brain.
Topics: Adenylyl Cyclases; Aging; Animals; Autoradiography; Brain; Brain Chemistry; Carcinogens; Colforsin; Male; Phorbol 12,13-Dibutyrate; Protein Binding; Protein Kinase C; Rats; Rats, Inbred F344; Second Messenger Systems; Tritium | 1995 |
Differences in isoproterenol stimulation of Ca2+ current of rat ventricular myocytes in neonatal compared to adult.
Topics: Adrenergic beta-Agonists; Aging; Animals; Animals, Newborn; Calcium Channel Agonists; Calcium Channels; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Heart; In Vitro Techniques; Isoproterenol; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley | 1996 |
Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina.
Topics: Aging; Animals; Bromodeoxyuridine; Cell Differentiation; Cell Division; Cells, Cultured; Colforsin; Crosses, Genetic; Cyclic AMP; Drosophila Proteins; Embryonic Induction; Female; Fibroblast Growth Factor 2; Gene Expression Regulation, Developmental; Hedgehog Proteins; In Situ Hybridization; Insect Hormones; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurons; Protein Biosynthesis; Proteins; Receptors, Cell Surface; Retina; Stem Cells; Trans-Activators; Transcription, Genetic; Transforming Growth Factor alpha | 1997 |
The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors.
Topics: Aging; Animals; Animals, Newborn; Brain; Cloning, Molecular; Colforsin; Cyclic AMP; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Humans; Inositol; Kinetics; Neuroprotective Agents; Phosphatidylinositols; Proline; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Resorcinols; Second Messenger Systems | 1996 |
Connexin32 gene expression in rat sciatic nerves and cultured Schwann cells.
Topics: Aging; Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Colforsin; Connexins; DNA Probes; Ganglia, Spinal; Gap Junction beta-1 Protein; Gene Expression; Immunohistochemistry; Myelin Sheath; Nerve Crush; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schwann Cells; Sciatic Nerve | 1997 |
Induction of tyrosine hydroxylase by forskolin: modulation with age.
Topics: Adrenal Medulla; Aging; Animals; Colforsin; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation, Enzymologic; Horseradish Peroxidase; Immunoenzyme Techniques; Luminescent Measurements; Male; Plasmids; Rats; Rats, Inbred F344; RNA, Messenger; Tissue Preservation; Transcriptional Activation; Tyrosine 3-Monooxygenase | 1997 |
Age-related deficits in the cerebellar beta adrenergic signal transduction cascade in Fischer 344 rats.
Topics: Aging; Animals; Cerebellum; Colforsin; Cyclic AMP; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta; Signal Transduction | 1997 |
Expression of adenylyl cyclase mRNAs in the adult, in developing, and in the Brattleboro rat kidney.
Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Arginine Vasopressin; Calcium; Cell Membrane; Colforsin; DNA Probes; Female; Fetus; Isoenzymes; Isoproterenol; Kidney; Kidney Cortex; Kidney Medulla; Kinetics; Male; Organ Specificity; Parathyroid Hormone; Polymerase Chain Reaction; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 1997 |
Age-related decreases in stimulatory G protein-coupled adenylate cyclase activity in osteoblastic cells.
Topics: Adenylyl Cyclases; Aging; Alkaline Phosphatase; Animals; Bone Development; Cells, Cultured; Cholera Toxin; Colforsin; Collagen; Cyclic AMP; Femur; GTP-Binding Proteins; Kinetics; Male; Osteoblasts; Osteopontin; Phosphoproteins; Rats; Rats, Inbred F344; Receptors, Parathyroid Hormone; Sialoglycoproteins; Teriparatide; Tibia; Transcription, Genetic | 1997 |
Modulatory effects of PKC activity on increased 92-kDa gelatinase secretion by neonatal alveolar macrophages.
Topics: Aging; Animals; Animals, Newborn; Bucladesine; Cell Membrane; Cells, Cultured; Colforsin; Concanavalin A; Cyclic AMP; Cysteine Endopeptidases; Enzyme Inhibitors; Gelatinases; Gene Expression Regulation, Enzymologic; Kinetics; Macrophages, Alveolar; Molecular Weight; Naphthalenes; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate | 1997 |
Myocardial action potential prolongation by calcium channel activation under calcium free-EGTA conditions in guinea-pigs: developmental and regional variations.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Adrenergic beta-Agonists; Aging; Animals; Bucladesine; Calcium; Calcium Channels; Colforsin; Egtazic Acid; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Phosphodiesterase Inhibitors | 1997 |
Late developmental changes in the ability of adenosine A1 receptors to regulate synaptic transmission in the hippocampus.
Topics: Aging; Animals; Calcium; Colforsin; Excitatory Postsynaptic Potentials; Extracellular Space; Hippocampus; In Vitro Techniques; Neurotransmitter Agents; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Synaptic Transmission; Theophylline | 1998 |
Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Cell Membrane; Colforsin; Ethanolamines; GTP-Binding Proteins; Imidazoles; Immunoblotting; Myocardium; Norepinephrine; Pertussis Toxin; Polymerase Chain Reaction; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; RNA; Sodium Fluoride; Virulence Factors, Bordetella | 1998 |
Glucocorticoid-targeting of the adenylyl cyclase signaling pathway in the cerebellum of young vs. aged rats.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Aging; Animals; Anti-Inflammatory Agents; Cerebellum; Colforsin; Dexamethasone; Fluorides; Glucocorticoids; GTP-Binding Proteins; Guanosine Triphosphate; Isoproterenol; Kidney; Male; Manganese; Rats; Rats, Sprague-Dawley; Signal Transduction | 1998 |
Age-dependent decrease in the negative inotropic effect of carbachol on isolated human right atrium.
Topics: Adolescent; Adult; Aged; Aging; Carbachol; Child; Child, Preschool; Colforsin; Female; Heart Atria; Humans; In Vitro Techniques; Male; Middle Aged; Myocardial Contraction | 1998 |
Differential down-regulation of beta3-adrenergic receptor mRNA and signal transduction by cold exposure in brown adipose tissue of young and senescent rats.
Topics: Adenylyl Cyclases; Adipose Tissue, Brown; Adrenergic beta-Agonists; Aging; Animals; Cold Temperature; Colforsin; Ethanolamines; Gene Expression Regulation; Male; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta; RNA, Messenger; Signal Transduction | 1999 |
Age-related differences in corticosterone secretion in female rats.
Topics: 3-Hydroxysteroid Dehydrogenases; Aging; Animals; Colforsin; Corticosterone; Cyclic AMP; Estradiol; Female; Ovariectomy; Prolactin; Rats; Rats, Sprague-Dawley; Steroid 11-beta-Hydroxylase; Steroid 21-Hydroxylase | 1999 |
Impaired cholera toxin relaxation with age in rat aorta.
Topics: Adenosine Diphosphate; Adrenergic beta-Agonists; Aging; Animals; Aorta, Thoracic; Cholera Toxin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; GTP-Binding Proteins; Isoproterenol; Male; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred F344; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Estrogen and progesterone stimulate Schwann cell proliferation in a sex- and age-dependent manner.
Topics: Aging; Animals; Animals, Newborn; Bromodeoxyuridine; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Estrogens; Female; Immunohistochemistry; Male; Progesterone; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve; Sex Factors; Thymidine | 1999 |
Impaired isoproterenol-induced hyperpolarization in isolated mesenteric arteries of aged rats.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Age Factors; Aging; Animals; Butoxamine; Colforsin; Cromakalim; Data Interpretation, Statistical; In Vitro Techniques; Isoproterenol; Male; Membrane Potentials; Mesenteric Arteries; Metoprolol; Muscle, Smooth, Vascular; Potassium Channels; Rats; Rats, Inbred WKY; Receptors, Adrenergic, beta; Vasodilator Agents | 1999 |
Age-related effects of oxidative metabolism and cyclic AMP signaling on neutrophil apoptosis.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antioxidants; Apoptosis; Bucladesine; Colforsin; Cyclic AMP; Dinoprostone; Female; Humans; In Vitro Techniques; Male; Neutrophils; Oxidation-Reduction; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 1999 |
Effect of aging on the negative chronotropic and anti-beta-adrenergic actions of adenosine in the rat heart.
Topics: Adenosine; Adrenergic beta-Antagonists; Aging; Animals; Cardiovascular Agents; Colforsin; Electrocardiography; Heart; Heart Rate; In Vitro Techniques; Male; Myocardium; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred F344; Receptors, Purinergic P1 | 1999 |
Age-sensitive and -insensitive pathways leading to JNK activation in mouse CD4(+) T-cells.
Topics: Aging; Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Ceramides; Colforsin; Cyclosporine; Dimethyl Sulfoxide; Enzyme Activation; Humans; Hydrogen Peroxide; Immunologic Memory; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; MAP Kinase Kinase 4; MAP Kinase Kinase 7; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Sorbitol; Ultraviolet Rays | 1999 |
Age-related endothelium-dependent vascular relaxation in rat thoracic aorta in response to colforsin.
Topics: Aging; Animals; Aorta, Thoracic; Colforsin; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Male; Nitric Oxide; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 1999 |
Quantitative autoradiography of [3H]forskolin binding sites in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits.
Topics: Adenylyl Cyclases; Aged; Aging; Alzheimer Disease; Autoradiography; Binding Sites; Brain; Brain Chemistry; Colforsin; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Neurofibrillary Tangles; Plaque, Amyloid; Postmortem Changes | 1999 |
Ontogeny of G-protein expression: control by beta-adrenoceptors.
Topics: Adrenergic beta-Agonists; Aging; Animals; Colforsin; Drug Tolerance; Female; Fluorides; Gene Expression Regulation, Developmental; GTP-Binding Proteins; Heart; Immunohistochemistry; Isoproterenol; Magnesium; Male; Myocardium; Oxidopamine; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Sympathetic Fibers, Postganglionic; Sympatholytics | 2000 |
Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Aging; Animals; Blotting, Western; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; GTP-Binding Proteins; Indoles; Isoproterenol; Muscle, Smooth; Pertussis Toxin; Pyrroles; Rats; Receptors, Adrenergic, beta; Urinary Bladder; Virulence Factors, Bordetella | 2000 |
Differential in vitro secretion of gonadotropin-releasing hormone (GnRH) and [hydroxyproline]GnRH from the rat hypothalamus during postnatal development.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Enzyme Activation; Female; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Male; Potassium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sexual Maturation; Tetradecanoylphorbol Acetate | 2000 |
Adolescent nicotine exposure alters cardiac autonomic responsiveness: beta-adrenergic and m2-muscarinic receptors and their linkage to adenylyl cyclase.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Aging; Animals; Animals, Newborn; Autonomic Nervous System; Carbachol; Cardiotonic Agents; Colforsin; Heart Conduction System; Isoproterenol; Manganese; Myocardium; Nicotine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptors, Adrenergic, beta; Receptors, Muscarinic | 2000 |
Angiotensin II enhances beta-adrenergic receptor-mediated vasorelaxation in aortas from young but not old rats.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Aging; Angiotensin II; Animals; Aorta, Thoracic; Bucladesine; Colforsin; Cyclic AMP; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Phosphodiesterase Inhibitors; Pyridines; Rats; Rats, Inbred F344; Receptor Cross-Talk; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Vasoconstrictor Agents; Vasodilation | 2000 |
Age-related differences in messenger ribonucleic acid expression of key proteins involved in adipose cell differentiation and metabolism.
Topics: Abdomen; Adipocytes; Adipose Tissue; Adult; Aging; Bucladesine; Canada; Cell Differentiation; Colforsin; Complement C3; France; Gene Expression Regulation, Developmental; Humans; Isoproterenol; Lipolysis; Lipoprotein Lipase; Male; Middle Aged; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sterol Esterase; Theophylline; Transcription Factors; Transcription, Genetic; White People | 2001 |
Effects of ageing on the activation metabolism of rat papillary muscles.
Topics: Aging; Animals; Calcium; Colforsin; Cyclic AMP; Energy Metabolism; Heart; Hypertrophy, Left Ventricular; In Vitro Techniques; Male; Muscle Development; Myocardial Contraction; Myocardium; Oxygen Consumption; Papillary Muscles; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Ventricular Function, Left | 2001 |
Regulation of prostacyclin and prostaglandin E(2) receptor mediated responses in adult rat dorsal root ganglion cells, in vitro.
Topics: Adenylyl Cyclases; Aging; Alprostadil; Animals; Antineoplastic Agents; Cell Count; Cells, Cultured; Colforsin; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Down-Regulation; Enzyme Activation; Epoprostenol; Ganglia, Spinal; Iloprost; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, Epoprostenol; Receptors, Prostaglandin | 2001 |
Attenuation of age-related declines in glucagon-mediated signal transduction in rat liver by exercise training.
Topics: Adenylyl Cyclases; Aging; Animals; Autoradiography; Cell Membrane; Colforsin; Cyclic AMP; Glucagon; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Immunoblotting; Iodine Radioisotopes; Liver; Male; Physical Endurance; Physical Exertion; Rats; Rats, Inbred F344; Receptors, Glucagon; Signal Transduction | 2001 |
Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal.
Topics: Aging; Animals; Avoidance Learning; Brain; Colforsin; Cyclic AMP; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression Regulation, Enzymologic; In Vitro Techniques; Intermediate Filament Proteins; Locus Coeruleus; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Morphine Dependence; Nerve Tissue Proteins; Nestin; Neurons; Neurotrophin 3; Signal Transduction; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase | 2001 |
Inhibition of forskolin-stimulated cAMP formation in vitro by paraoxon and chlorpyrifos oxon in cortical slices from neonatal, juvenile, and adult rats.
Topics: Aging; Animals; Animals, Newborn; Chlorpyrifos; Colforsin; Cyclic AMP; Female; In Vitro Techniques; Male; Paraoxon; Pregnancy; Rats; Rats, Sprague-Dawley | 2001 |
Changes in the second messenger cyclic AMP during development may underlie motoric symptoms in attention deficit/hyperactivity disorder (ADHD).
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Attention Deficit Disorder with Hyperactivity; Colforsin; Cyclic AMP; Dopamine Agonists; Female; Male; Motor Activity; Neostriatum; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Second Messenger Systems | 2002 |
Involvement of cAMP but not PKA in the increase of corticosterone secretion in rat zona fasciculata-reticularis cells by aging.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Adrenocorticotropic Hormone; Aging; Animals; Carrier Proteins; Colforsin; Corticosterone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Desoxycorticosterone; Female; Intracellular Signaling Peptides and Proteins; Isoquinolines; Ovariectomy; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Prolactin; Rats; Rats, Sprague-Dawley; Sulfonamides; Zona Fasciculata; Zona Reticularis | 2002 |
Pharmacological profile of evodiamine in isolated rabbit corpus cavernosum.
Topics: Aging; Animals; Colforsin; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle Relaxation; Nitric Oxide Donors; Nitroprusside; Nucleotides, Cyclic; Penis; Plant Extracts; Potassium; Potassium Channel Blockers; Quinazolines; Rabbits | 2002 |
Thyrotropin action is impaired in the thyroid gland of old rats.
Topics: Adenylyl Cyclases; Aging; Animals; Cell Membrane; Colforsin; Cyclic AMP; Guanosine Triphosphate; Male; Rats; Rats, Inbred Strains; Thyroid Gland; Thyroid Hormones; Thyrotropin | 1992 |
Influence of animal age on the beta-adrenergic system in cultured rat aortic and mesenteric artery smooth muscle cells.
Topics: Aging; Alprostadil; Animals; Aorta, Thoracic; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Iodocyanopindolol; Isoproterenol; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Pindolol; Propranolol; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta | 1992 |
Beta-adrenergic responsiveness in cultured aorta smooth muscle cells. Effects of subculture and aging.
Topics: Adenylyl Cyclases; Aging; Animals; Aorta, Thoracic; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Activation; Isoproterenol; Microscopy, Phase-Contrast; Muscle, Smooth, Vascular; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta | 1992 |
Developmental changes in the modulation of cyclic AMP formation by the metabotropic glutamate receptor agonist 1S,3R-aminocyclopentane-1,3-dicarboxylic acid in brain slices.
Topics: Aging; Animals; Animals, Newborn; Brain; Colforsin; Cyclic AMP; Cycloleucine; Dose-Response Relationship, Drug; Hippocampus; Hypothalamus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Reduced contractile responses to forskolin and a cyclic AMP analogue in myocytes from failing human ventricle.
Topics: Adult; Aging; Bucladesine; Calcium; Colforsin; Diuretics; Female; Heart Failure; Heart Ventricles; Humans; In Vitro Techniques; Isoproterenol; Male; Middle Aged; Myocardial Contraction | 1992 |
Adenosine receptors, cyclic AMP accumulation, and DNA-synthesis in aortic smooth muscle cell cultures of adult and neonatal rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aging; Animals; Aorta; Cells, Cultured; Colforsin; Cyclic AMP; DNA; Muscle, Smooth, Vascular; Phenylisopropyladenosine; Rats; Rats, Sprague-Dawley; Receptors, Purinergic | 1992 |
Slow and medium afterhyperpolarizations in maturing rat hippocampal CA1 neurones.
Topics: Aging; Analysis of Variance; Animals; Carbachol; Colforsin; Female; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neurons; Norepinephrine; PC12 Cells; Pyramidal Tracts; Rats; Rats, Wistar | 1992 |
Adenylyl cyclase activity in postmortem human brain: evidence of altered G protein mediation in Alzheimer's disease.
Topics: Adenylyl Cyclases; Aged; Aged, 80 and over; Aging; Aluminum; Aluminum Compounds; Alzheimer Disease; Brain; Cadaver; Colforsin; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Reference Values; Time Factors | 1992 |
Postnatal development of regional binding of corticotropin-releasing factor and adenylate cyclase activity in the rat brain.
Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Brain; Brain Chemistry; Colforsin; Corticotropin-Releasing Hormone; Rats; Rats, Inbred Strains; Signal Transduction; Social Isolation | 1992 |
Beta-adrenergic responsiveness in cultured vascular smooth muscle cells and fibroblasts: effect of age.
Topics: Aging; Analysis of Variance; Animals; Aorta; Cells, Cultured; Colforsin; Cyclic AMP; Fibroblasts; Isoproterenol; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta; Regression Analysis | 1991 |
Beta-adrenergic signal transduction in aging parotid and submandibular salivary glands.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Dose-Response Relationship, Drug; Enzyme Activation; Female; Isoproterenol; Parotid Gland; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta; Regression Analysis; Signal Transduction; Submandibular Gland | 1991 |
Ontogeny of beta-adrenergic receptor-mediated cyclic AMP generating system in primary cultured neurons.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Aging; Animals; Brain; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dihydroalprenolol; Fetus; Guanylyl Imidodiphosphate; Isoproterenol; Kinetics; Mice; Mice, Inbred Strains; Neurons; Pertussis Toxin; Receptors, Adrenergic, beta; Sodium Fluoride; Virulence Factors, Bordetella | 1991 |
Multiple adrenergic receptor subtypes controlling cyclic AMP formation: comparison of brain slices and primary neuronal and glial cultures.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Drug Synergism; Isoproterenol; Kinetics; Neuroglia; Neurons; Norepinephrine; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Yohimbine | 1991 |
Prenatal terbutaline treatment: tissue-selective dissociation of perinatal changes in beta-adrenergic receptor binding from regulation of adenylate cyclase activity.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Aging; Animals; Body Weight; Colforsin; Down-Regulation; Female; Litter Size; Liver; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Terbutaline; Tissue Distribution | 1991 |
Ontogeny of the adenylate cyclase system in the pulmonary vascular smooth muscle of the fetal lamb.
Topics: Adenylyl Cyclases; Aging; Animals; Cell Membrane; Colforsin; Cyclic AMP; Embryonic and Fetal Development; Female; Fetus; Guanosine Triphosphate; Isoproterenol; Muscle Development; Muscle, Smooth, Vascular; Pregnancy; Pulmonary Circulation; Receptors, Adrenergic, beta; Sheep; Sodium Fluoride; Stimulation, Chemical | 1991 |
Decreased beta-adrenoceptor-mediated vasodilation in aorta from aged rats: possible involvement of a stimulatory GTP-binding protein.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Aging; Animals; Aorta; Clenbuterol; Colforsin; Cyclic AMP; Female; GTP-Binding Proteins; Isoproterenol; Male; Muscle Relaxation; Phosphodiesterase Inhibitors; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Vasodilation | 1991 |
Effects of ageing on the growth and differentiated function of transfected human thyrocytes.
Topics: Adenylyl Cyclases; Aging; Binding, Competitive; Cell Differentiation; Cell Division; Cell Line; Cholera Toxin; Colforsin; Flow Cytometry; Humans; Kinetics; Propidium; Thyroid Gland; Thyrotropin; Transfection | 1991 |
Regulation of postnatal beta-adrenergic receptor/adenylate cyclase development by prenatal agonist stimulation and steroids: alterations in rat kidney and lung after exposure to terbutaline or dexamethasone.
Topics: Adenylyl Cyclases; Aging; Analysis of Variance; Animals; Binding Sites; Body Weight; Colforsin; Dexamethasone; Drug Synergism; Female; Isoproterenol; Kidney; Lung; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Terbutaline | 1990 |
Release of interleukin-6 from anterior pituitary cell aggregates: developmental pattern and modulation by glucocorticoids and forskolin.
Topics: Adenylyl Cyclases; Aging; Animals; Cell Aggregation; Cells, Cultured; Colforsin; Dexamethasone; Dihydrotestosterone; Estradiol; Female; Interleukin-6; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains | 1991 |
Age-related deficit in beta receptor stimulation of cAMP binding in blood vessels.
Topics: Aging; Animals; Aorta, Thoracic; Colforsin; Cyclic AMP; In Vitro Techniques; Isoproterenol; Kinetics; Male; Muscle, Smooth, Vascular; Protein Kinases; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1990 |
Role of beta-adrenoceptor-adenylate cyclase system in the developmental decrease in sensitivity to isoprenaline in foetal and neonatal rat heart.
Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Colforsin; Dihydroalprenolol; Enzyme Activation; Female; Fetus; Heart; Heart Rate; Isoproterenol; Kinetics; Myocardial Contraction; Myocardium; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1990 |
Influence of age on the rhythm in basal and forskolin-stimulated adenylate cyclase activity of the rat heart.
Topics: Adenylyl Cyclases; Aging; Animals; Circadian Rhythm; Colforsin; Heart Ventricles; Male; Myocardium; Rats; Rats, Inbred Strains | 1990 |
Forskolin activation of adenylate cyclase in rat myocardium with age: effects of guanine nucleotide analogs.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Female; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Heart; Myocardium; Rats; Rats, Inbred F344; Thionucleotides | 1990 |
Age-related decrease in beta adrenergic receptor-mediated vascular smooth muscle relaxation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Aging; Bucladesine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Iodocyanopindolol; Isoproterenol; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Pindolol; Receptors, Adrenergic, beta; Serotonin | 1986 |
Desensitization to parathyroid hormone in renal cells from aged rats is associated with alterations in G-protein activity.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Aging; Animals; Calcium; Cholera Toxin; Colforsin; GTP-Binding Proteins; Kidney; Male; Parathyroid Hormone; Pertussis Toxin; Rats; Rats, Inbred Strains; Sodium; Virulence Factors, Bordetella | 1989 |
Role of cyclic AMP-dependent protein kinase in the diminished beta adrenergic responsiveness of vascular smooth muscle with increasing age.
Topics: Aging; Animals; Aorta; Colforsin; Cyclic AMP; In Vitro Techniques; Isoproterenol; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Protein Kinases; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Timolol | 1989 |
Decrease with senescence in the norepinephrine-induced phosphorylation of myofilament proteins in isolated rat cardiac myocytes.
Topics: Actin Cytoskeleton; Aging; Animals; Carrier Proteins; Cells, Cultured; Colforsin; Cyclic AMP; Cytoskeleton; Densitometry; Male; Muscle Proteins; Myocardium; Norepinephrine; Phosphodiesterase Inhibitors; Phosphorylation; Rats; Troponin; Troponin I | 1989 |
Growth hormone secretion by individual somatotropes of the testicular feminized rat.
Topics: Aging; Androgen-Insensitivity Syndrome; Animals; Body Weight; Cell Count; Colforsin; Estradiol; Female; Gonadotropin-Releasing Hormone; Growth Hormone; Hemolytic Plaque Technique; Male; Pituitary Gland; Rats; Testosterone | 1989 |
Emergence of beta adrenergic-responsive hepatic glycogenolysis in male rats during post-maturational aging.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Enzyme Activation; Epinephrine; Glucagon; Glucose; Glycogen; Isoproterenol; Liver; Male; Propranolol; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta | 1987 |
Stimulation and inhibition of lipolysis in isolated rat adipocytes: evidence for age-related changes in responses to forskolin and PGE1.
Topics: Adipose Tissue; Aging; Animals; Colforsin; Cyclic AMP; In Vitro Techniques; Isoproterenol; Lipolysis; Male; Phenylisopropyladenosine; Prostaglandins E; Rats; Rats, Inbred Strains | 1987 |
Age-related and testicular regression-induced changes in adenosine 3',5'-monophosphate responses in cultured hamster Sertoli cells.
Topics: Adenosine Triphosphate; Adenylate Cyclase Toxin; Aging; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Follicle Stimulating Hormone; Isoproterenol; Male; Mesocricetus; Pertussis Toxin; Reference Values; Sertoli Cells; Testis; Time Factors; Virulence Factors, Bordetella | 1988 |
Age-associated decrease in beta-adrenergic receptors and adenylate cyclase activity in rat brown adipose tissue.
Topics: Adenylyl Cyclases; Adipose Tissue, Brown; Aging; Animals; Body Temperature Regulation; Colforsin; Electron Transport Complex IV; Isoproterenol; Male; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta; Sodium Fluoride | 1988 |
cAMP metabolism and lipolysis in brown adipocytes of hamsters consuming a cafeteria diet.
Topics: Adenylyl Cyclases; Adipose Tissue, Brown; Aging; Animals; Body Temperature Regulation; Colforsin; Cricetinae; Cyclic AMP; Diet; Diterpenes; Isoproterenol; Lipolysis; Male | 1985 |
Responsiveness of immature versus adult male rat hypothalami to dibutyryl cyclic AMP- and forskolin-induced LHRH release in vitro.
Topics: Aging; Animals; Bucladesine; Butyrates; Butyric Acid; Colforsin; Diterpenes; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; In Vitro Techniques; Male; Rats | 1985 |
Lymphocyte protein kinase activity in cells from young and elderly men and women.
Topics: Adult; Aged; Aging; Colforsin; Cyclic AMP; Cyclic GMP; Enzyme Activation; Female; Humans; Isoproterenol; Lymphocytes; Male; Middle Aged; Propranolol; Protein Kinases; Sex Factors | 1985 |
Parathyroid hormone increases sodium/calcium exchange activity in renal cells and the blunting of the response in aging.
Topics: Aging; Animals; Calcium; Choline; Colforsin; Cyclic AMP; Kidney; Male; Parathyroid Glands; Parathyroid Hormone; Rats; Rats, Inbred Strains; Sodium; Sodium Chloride | 1986 |
Diminished pituitary responsiveness to growth hormone-releasing factor in aging male rats.
Topics: Aging; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Growth Hormone; Growth Hormone-Releasing Hormone; Kinetics; Male; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
Alpha 2-adrenoceptor-GTP binding regulatory protein-adenylate cyclase system in cerebral cortical membranes of adult and senescent rats.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Aging; Animals; Cerebral Cortex; Clonidine; Colforsin; Epinephrine; Female; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Male; Membranes; NAD; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella | 1986 |
Effect of age on the formation of cyclic nucleotides in guinea-pig tracheal smooth muscle in response to pharmacological agents.
Topics: Aging; Alprostadil; Animals; Carbachol; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic GMP; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscle, Smooth; Nitroprusside; Potassium; Trachea | 1986 |
Beta-adrenergic receptors, glucagon receptors, and their relationship to adenylate cyclase in rat liver during aging.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Enzyme Activation; Glucagon; Guanine Nucleotides; Guanylyl Imidodiphosphate; Isoproterenol; Liver; Male; Pindolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Sodium Fluoride | 1987 |
Effect of age on parathyroid hormone and forskolin stimulated adenylate cyclase and protein kinase activity in the renal cortex.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Cyclic AMP; Kidney Cortex; Male; Parathyroid Hormone; Protein Kinases; Rats; Rats, Inbred F344; Receptors, Cell Surface; Receptors, Parathyroid Hormone | 1986 |
Diet restriction retards the age-related loss of beta-adrenergic receptors and adenylate cyclase activity in rat lung.
Topics: Adenylyl Cyclases; Aging; Animal Nutritional Physiological Phenomena; Animals; Colforsin; Diet; Epinephrine; Isoproterenol; Lung; Male; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta | 1987 |
Decreased stimulation of adenylate cyclase by growth hormone-releasing factor in the anterior pituitary of old rats.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Growth Hormone-Releasing Hormone; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Sodium Fluoride; Vasoactive Intestinal Peptide | 1986 |
Effect of age and posture on human lymphocyte adenylate cyclase activity.
Topics: Adenylyl Cyclases; Adult; Aged; Aged, 80 and over; Aging; Colforsin; Humans; Lymphocytes; Male; Norepinephrine; Posture | 1988 |
Inotropic responses change during postnatal maturation in rabbit.
Topics: Aging; Animals; Animals, Newborn; Cardiotonic Agents; Colforsin; Female; Heart; Imidazoles; Isoproterenol; Male; Milrinone; Myocardial Contraction; Pyridones; Rabbits; Reference Values; Software | 1988 |
Influences of pertussis toxin, guanine nucleotides and forskolin on adenylate cyclase in striatal membranes of infant, adult and senescent rats.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Aging; Animals; Colforsin; Corpus Striatum; Dopamine; Female; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Male; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Virulence Factors, Bordetella | 1987 |
Human aging: effect on the activation of lymphocyte cyclic AMP-dependent protein kinase by forskolin.
Topics: Adult; Aged; Aging; Colforsin; Enzyme Activation; Humans; In Vitro Techniques; Kinetics; Lymphocytes; Middle Aged; Protein Kinases | 1987 |
Alterations of rat cardiac adenylate cyclase activity with age.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Glucagon; Guanylyl Imidodiphosphate; Isoproterenol; Male; Myocardium; Rats; Rats, Inbred Strains; Secretin; Sodium Fluoride | 1986 |
Age dependence of adenylate cyclase in guinea pig ureter homogenate.
Topics: Adenylyl Cyclases; Aging; Alprostadil; Animals; Colforsin; Enzyme Activation; Ethanol; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Isoproterenol; Male; Muscle Contraction; Propranolol; Sodium Fluoride; Ureter | 1986 |