colchicine has been researched along with Disease Models, Animal in 154 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (12.34) | 18.7374 |
| 1990's | 14 (9.09) | 18.2507 |
| 2000's | 39 (25.32) | 29.6817 |
| 2010's | 57 (37.01) | 24.3611 |
| 2020's | 25 (16.23) | 2.80 |
| Authors | Studies |
|---|---|
| Bednarski, PJ; Gastpar, R; Kaufmann, D; Nishino, T; Pojarová, M; Reszka, P; von Angerer, E | 1 |
| Berridge, MV; Chia, EW; Copp, BR; Denny, WA; Godfrey, CA; Hanton, LR; Harper, JL; Larsen, L; Lu, GL; Pearce, AN; Perry, NB; Sansom, CE; Walton, M; Webb, VL | 1 |
| Chang, DJ; Jang, J; Kim, SO; Kim, WJ; Lee, S; Suh, YG | 1 |
| Alves de Lima, Mdo C; Campos, JF; da Cruz Amorim, CA; da Silva, AL; de Oliveira, JF; Ernesto de Carvalho, J; Neves, JL; Olímpio de Moura, R; Ribeiro, AG; Ruiz, AL; Vendramini-Costa, DB | 1 |
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Ha, EH; Hu, Q; Li, H; Li, Z; Pang, J; Tian, S; Wang, W; Zhou, M | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Byun, HO; Islam, SMS; Jung, JY; Kim, HA; Ryu, HM; Sayeed, HM; Sohn, S; Suh, CH | 1 |
| Li, P; Liu, W; Qu, X; Sun, X | 1 |
| Bell, CJ; Hitt, MM; Lewis, JD; Pink, D; Potts, KG; Tuszynski, JA | 1 |
| Lei, H; Li, X; Zhang, J | 1 |
| Chong, A; Contreras, JE; Fraidenraich, D; Himelman, E; Lillo, MA; Nouet, J; Rodney, GG; Shirokova, N; Wehrens, XHT; Xie, LH; Zhou, D | 1 |
| Colbourne, F; Katsanos, AH; Kung, TFC; Sander, NH; Shoamanesh, A; Wilkinson, CM | 1 |
| Arazi, E; Landau, D; Segev, Y; Shukri, N; Tobar, A | 1 |
| Chen, YX; Fu, H; Li, DJ; Li, Q; Shen, FM; Shen, QR; Shi, Y; Wu, WB; Zhao, Y | 1 |
| Gu, J; Liang, W; Qin, X; Wu, Z; Yue, H; Zhang, T; Zhao, X; Zhu, G | 1 |
| Kanoujia, J; Kumar, P; Mazhar, I; Parashar, P; Saha, S; Saraf, SA; Yadav, A | 1 |
| Abdeen, S; Abu-Fanne, R; Bdeir, K; Cines, DB; Heyman, SN; Higazi, AA; Higazi, M; Maraga, E; Masarwy, A | 1 |
| Barbas, C; Cecconi, A; Godzien, J; Ibañez, B; Izidoro, MA; López-Gonzálvez, Á; Mateo, J; Panadero, MI; Ruiz-Cabello, J; Rupérez, FJ; Vilchez, JP | 1 |
| Chen, L; Du, Y; Han, B; Huang, Z; Liao, J; Liu, H; Tse, G; Wu, Q; Zhao, N | 1 |
| Cheng, Z; Liu, T; Yue, Q | 1 |
| Al-Qazazi, R; Archer, SL; Eklund, M; Hartweck, L; Hsu, S; Neuber-Hess, M; Potus, F; Prins, KW; Prisco, SZ; Rose, L; Thenappan, T; Tian, L; Wu, D | 1 |
| Hatayama, M; Igarashi, S; Ishioh, M; Kumei, S; Nozu, T; Okumura, T; Saito, T; Shindo, M; Tanabe, H; Toki, Y; Yamamoto, M | 1 |
| Dimitriou, I; Fine, N; Glogauer, M; Gracey, E; La Rose, J; Rottapel, R | 1 |
| Brand, G; Charpentier, D; Clavet-Lanthier, MÉ; Dupuis, J; Mihalache-Avram, T; Neagoe, PE; Nguyen, QT; Rhainds, D; Rhéaume, E; Sirois, MG; Tardif, JC; Théberge-Julien, G | 1 |
| Hao, Y; Jiang, B; Wen, W; Zhang, Z | 1 |
| Lv, XW; Shuai, C; Wang, S; Xia, GQ; Yuan, F | 1 |
| Arumugam, K; Bojja, SL; Kumar, N; Rao, CM; Rompicherla, SKL | 1 |
| Igarashi, S; Ishioh, M; Kumei, S; Nozu, T; Ohhira, M; Okumura, T | 1 |
| Bakoyiannis, C; Iliopoulos, D; Kapelouzou, A; Liakakos, T; Mastrogeorgiou, M; Mylonas, KS; Nikiteas, N; Schizas, D; Spartalis, E; Spartalis, M | 1 |
| Li, C; Li, Q; Li, Z; Lu, C; Peng, Y; Song, L; Wang, L; Wang, Y; Xia, D; Yu, A | 1 |
| Aguilhon, S; Akodad, M; Blandel, F; Bourret, A; de Santa Barbara, P; Fauconnier, J; Huet, F; Hugon, G; Lacampagne, A; LeGall, M; Roubille, F; Sicard, P | 1 |
| Fujisue, K; Ishii, M; Izumiya, Y; Kaikita, K; Kurokawa, H; Matsubara, J; Sugamura, K; Sugiyama, S | 1 |
| Itano, S; Kadoya, H; Kashihara, N; Sasaki, T; Satoh, M; Sogawa, Y; Uchida, A | 1 |
| Archer, SL; Metzger, JM; Prins, KW; Thenappan, T; Tian, L; Wu, D | 1 |
| Acuner, B; Aslan, G; Baser, NT; Caydere, M; Görgü, M; Terzioglu, A; Ustun, H | 1 |
| Choi, B; Islam, SMS; Sayeed, HM; Sohn, S | 1 |
| Bhatt, PC; Kumar, V; Panda, BP; Pathak, S | 1 |
| Bai, Z; Dong, F; Han, Y; He, L; Li, G; Li, R; Liu, H; Niu, M; Sang, X; Wang, B; Wang, J; Xiao, X; Yin, P; Zhang, C | 1 |
| Ahn, JS; Cha-Molstad, H; Choi, TW; Han, HJ; Hong, JT; Hwang, J; Kim, BY; Kim, HJ; Kwon, YT; Lee, HG; Lee, KH; Lee, Y; Mun, J; Soung, NK | 1 |
| Bakhta, O; Blanchard, S; Guihot, AL; Jeannin, P; Mirebeau-Prunier, D; Prunier, F; Tamareille, S | 1 |
| Choi, BY; Suh, SW | 1 |
| Jiang, X; Kumar, M; Zhu, Y | 1 |
| Ehteda, A; Galettis, P; Morris, DL; Pillai, K | 1 |
| Canpolat, FE; Dilmen, U; Erdeve, O; Oncel, MY; Ozdemir, R; Unverdi, HG; Uysal, B; Yurttutan, S | 1 |
| Chen, G; Chen, X; Gao, B; Guan, T; Ingram, AJ; Janssen, M; Krepinsky, JC; Uttarwar, L | 1 |
| Anower, AK; Choi, B; Kwon, HJ; Shim, JA; Sohn, S | 1 |
| Jiang, H; Liu, XC; Wang, YZ; Xue, X | 1 |
| Anderson, ME; Chen, B; Gao, S; Guo, A; Hong, J; Johnson, FL; Kutschke, W; Miller, JD; Santana, LF; Song, LS; Wehrens, XH; Weiss, RM; Yuan, C; Zhang, C; Zhu, Y; Zimmerman, K | 1 |
| Dogan Ekici, I; Ekici, S; Sinanoglu, O | 1 |
| Dutta, G; Ghosh, T; Goswami, AR; Sil, S | 1 |
| Chang, DJ; Kim, WJ | 1 |
| Atasever, A; Yaman, D | 1 |
| Asiedu, MN; Dussor, G; Ghosh, S; Mandell, EK; Melemedjian, OK; Moy, JK; Price, TJ; Tillu, DV | 1 |
| Albayrak, A; Hakverdi, AU; Karateke, A; Kurt, RK; Okyay, AG; Özdemir, S; Pinar, N; Silfeler, DB | 1 |
| Chang, SL; Chen, SA; Chen, YC; Chen, YJ; Chiou, CW; Chong, E; Ha, TL; Hsiao, YW; Hsu, CP; Lin, YJ; Liu, SH; Lo, LW; Singhal, R; Tsai, YN | 1 |
| Aslan, MK; Atasoy, P; Boybeyi, Ö; Gunal, YD; Kısa, U | 1 |
| Albayrak, A; Delibasi, T; Dogan, AC; Dogan, M; Duru, M; Eren, F; Fadillioglu, E; Karateke, A; Kurt, RK; Kurt, SN; Okyay, AG | 1 |
| Chen, Y; Jiang, M; Ren, D; Wang, P; Wang, R; Wang, YG | 1 |
| Chai, KM; Cheng, CC; Fang, KM; Hsieh, YT; Li, CC; Lien, YA; Liu, JJ; Tzeng, SF | 1 |
| Aksoy, AN; Dokuyucu, R; Gozukara, IO; Kucur, SK; Kurt, RK; Ozcan, O; Ozgur, T; Pınar, N | 1 |
| Ghosh, R; Ghosh, T; Sil, S | 1 |
| Ghosh, T; Sil, S | 2 |
| Collier, TJ; Kanaan, NM; Kneynsberg, A; Manfredsson, FP | 1 |
| Barrio, RA; Chay, FK; Hernández, VS; Vázquez-Juárez, E; Zhang, L | 1 |
| Emmens, RW; Fong Hing, G; Heymans, S; Juffermans, LJ; Krijnen, PA; Murk, JL; Niessen, HW; Smilde, BJ; van Ham, M; van Rossum, AC; Woudstra, L; Wouters, D; Zeerleder, S | 1 |
| Ghosh, A; Ghosh, T; Sil, S | 1 |
| Apers, S; Capistrano I, R; Fransen, E; Pieters, L; Staelens, S; Vangestel, C; Vanpachtenbeke, H | 1 |
| Han, JS; Heo, NJ; Jung, ES; Kim, S; Lee, J; Na, KY | 1 |
| Nuki, G | 1 |
| Bicak, S; Bozkurt, D; Duman, S; Ertilav, M; Hur, E; Sen, S; Sipahi, S; Taskin, H | 1 |
| Brighente, IM; Cazarolli, LH; Folador, P; Moresco, HH; Pizzolatti, MG; Silva, FR | 1 |
| Gonzalez-Cadavid, NF; Rajfer, J | 1 |
| Basson, MD; Craig, DH | 1 |
| Han, DS; Han, SH; Jin, R; Jung, DS; Kang, SW; Kim, DK; Kim, SH; Kwak, SJ; Lee, JE; Lee, SH; Li, JJ; Moon, SJ; Ryu, DR; Yoo, TH | 1 |
| Bache, RJ; Chen, Y; Fassett, JT; French, J; Hu, X; Xu, X; Zhu, G | 1 |
| Croll, SD; Dore, A; Hylton, DM; Liu-Bryan, R; Macdonald, L; Murphy, AJ; Reinhardt, J; Rudge, JS; Stevens, S; Terkeltaub, RA; Torres, R; Yancopoulos, GD | 1 |
| Altinors, N; Calisaneller, T; Caner, H; Kiyici, H; Ozdemir, O; Sonmez, E | 1 |
| Dogra, S; Kumar, A; Prakash, A | 1 |
| Montero-Melendez, T; Patel, HB; Perretti, M | 1 |
| Ephraim, E; Haim, G; Haim, S; Ronen, P | 1 |
| Andrés, ME; Campos-Melo, D; Forray, MI; Gysling, K; Noches, V; Quiroz, G | 1 |
| Aquilina, K; Hogan, S; Hoque, N; Thoresen, M; Whitelaw, A | 1 |
| Goebel-Stengel, M; Ohning, G; Stengel, A; Taché, Y; Wang, L; Wu, SV | 1 |
| Kokare, DM; Nakhate, KT; Rangani, RJ; Subhedar, NK; Upadhya, MA | 1 |
| Arikok, AT; Demirci, A; Gökyaprak, SM; Gürer, B; Kertmen, H; Sekerci, Z; Yilmaz, ER | 1 |
| Canzian, M; Fernandes, F; Ianni, BM; Mady, C; Oliveira, AM; Pessoa, FG; Ramires, FJ; Salemi, VM | 1 |
| Dilmen, U; Erdeve, O; Oguz, SS; Ozdemir, R; Talim, B; Uysal, B; Yurttutan, S | 1 |
| Arias-Carrión, O; El-Gamal, M; Ellaithy, A; Helmy, B; Mohamed, M; Salama, M; Sheashaa, H; Sobh, M; Tantawy, D | 1 |
| Kim, JH; Kim, SC | 1 |
| Ashour, AE; Attia, SM; Bakheet, SA | 1 |
| Apte, UM; Bucci, TJ; Manautou, JE; Mehendale, HM; Ronis, MJ; Shankar, K; Vaidya, VS | 1 |
| Deheza, R; Muriel, P | 1 |
| Cocco, GA; De Riu, P; Deiana, GA; Mameli, O; Rosati, G; Sechi, G | 1 |
| Day, JR; Ewing, AG; Frank, AT; Goetting-Minesky, MP; Krady, JK; Lang, MG; Milner, RJ; Patel, SP; Price, M; Silviera, ML | 1 |
| Chechik, A; Cohen, I; Dudkiewicz, I; Horowitz, S; Langevitz, P; Livneh, A; Perelman, M; Regev, S; Salai, M; Strasburg, S | 1 |
| Camins, A; Camps, P; Canudas, AM; Jiménez, A; Jordá, EG; Muñoz-Torrero, D; Pallàs, M; Rimbau, V; Verdaguer, E | 1 |
| Gahm, C; Holmin, S; Mathiesen, T; Rudehill, S | 1 |
| Aiqun, M; Geru, W; Tao, G; Xiaojun, B; Yutao, X | 1 |
| Martinon, F; Mayor, A; Pétrilli, V; Tardivel, A; Tschopp, J | 1 |
| Karaoglu, AO; Ozutemiz, O; Vardar, E; Yenisey, C; Yukselen, O; Yukselen, V | 1 |
| Adler, Y; Brucato, A; Spodick, DH | 1 |
| Aquino, JB; Coronel, MF; Musolino, PL; Setton-Avruj, CP; Villar, MJ | 1 |
| Kumar, A; Naidu, PS; Padi, SV; Seghal, N | 1 |
| Chen, CS; Lee, YP; Lei, HY; Lin, SC; Liu, CC; Wang, JR; Wang, YF; Yao, YC; Yu, CK | 1 |
| Abdel Raheim, SR; Atta, HM; El-Rehany, MA; Fouad, R; Galal, AM | 1 |
| Muriel, P; Rivera-Espinoza, Y | 1 |
| Huang, YS; Kuang, Y | 1 |
| McCarty, DJ | 1 |
| Chia, EW; Grainger, R; Harper, JL | 1 |
| Blazek, J; Muehlberger, T; Ottomann, C | 1 |
| Jackson, D; Mowat, AP; Tanner, MS | 1 |
| Bhaskar, K; Coles, S; Reid, L | 1 |
| Dasheiff, RM; McNamara, JO | 1 |
| Dällenbach, A; Renner, EL | 1 |
| Apple, DJ; Assia, EI; Bluestein, EC; Castaneda, VE; Legler, UF; Mowbray, SL | 1 |
| Adachi, M; Kishida, S; Saitoh, Y; Takeyama, Y; Toyokawa, A; Ueda, T; Yamamoto, M | 1 |
| Ghio, AJ; Hatch, GE | 1 |
| Bing, OH; Brooks, WW; Cicogna, AC; Conrad, CH; Hayes, JA; Robinson, KG; Sen, S | 1 |
| Karmeli, F; Rachmilewitz, D; Stalnikowicz, R | 1 |
| Bhattacharya, SK; Kumar, A | 1 |
| Aguirre-Cruz, L; Sotelo, J | 1 |
| Comellas, AP; Lecuona, E; Ridge, KM; Saldías, FJ; Sznajder, JI | 1 |
| Bakircioglu, ME; Bhatnagar, RS; Dahiya, R; El-Sakka, AI; Lue, TF; Yen, TS | 1 |
| Frye, CA; Vongher, JM | 1 |
| Cheng, M; Lu, T; Lu, Y | 1 |
| Furuoka, H; Kobayashi, Y; Matsui, T; Yamada, M | 1 |
| Burrows, PC; Das, D; Gordon, C; McMahon, RF; Pemberton, PW; Smith, A; Warnes, TW | 1 |
| Akerud, P; Alberch, J; Arenas, E; Canals, JM; Checa, N; Marco, S; Michels, A; Pérez-Navarro, E; Tolosa, E | 1 |
| Chen, L; Liu, Y | 1 |
| Gal, R; Livneh, A; Pras, M; Salai, M; Shtrasburg, S | 1 |
| Lu, MC | 1 |
| Chang, E; Dellon, AL; Dellon, ES; Hendrickson, ME | 1 |
| Barrows, LR; Edler, MC; Fernandez, AM; Ireland, CM; Lassota, P | 1 |
| Bulenga, G; Heaney, T | 1 |
| Berlin, RD; Oliver, JM; Zurier, RB | 1 |
| Goldlust, MB; Harrity, TW; Rich, LC | 1 |
| Denko, CW; Whitehouse, MW | 1 |
| Barluzzi, R; Bistoni, F; Blasi, E; Mazzolla, R; Mosci, P | 1 |
| Blackham, A; Griffiths, RJ; Li, SW; Wood, BE | 1 |
| Arancibia, S; Litovsky, B | 1 |
| Meza, MA; Mourelle, M | 1 |
| Hahn, BL; Sohnle, PG | 1 |
| Brooks, PM; Burton, D; Forrest, MJ | 1 |
| Lees, P; Sedgwick, AD | 1 |
| Last, JA | 1 |
| Higuchi, K; Hosokawa, M; Kohno, A; Matsumura, A; Matsushita, M; Takeda, T; Takeshita, S; Yonezu, T | 1 |
| Cohen, AS; Shirahama, T | 1 |
| Robinson, JW | 1 |
| Gafni, J; Kedar, I; Ravid, M; Sohar, E | 1 |
| Gloor, BP | 1 |
| Akinosho, EA; Basu, PK | 1 |
| D'Agostino, AN; Markand, ON | 1 |
9 review(s) available for colchicine and Disease Models, Animal
| Article | Year |
|---|---|
Antimicrotubule Agent-Induced Zinc Neurotoxicity.
Topics: Animals; Cation Transport Proteins; Cell Death; Cognitive Dysfunction; Colchicine; Disease Models, Animal; Hippocampus; Humans; Mice; Microtubules; Neurogenesis; Neurons; Neurotoxicity Syndromes; Paclitaxel; Presynaptic Terminals; Tubulin Modulators; Vincristine | 2018 |
Colchicine: its mechanism of action and efficacy in crystal-induced inflammation.
Topics: Animals; Arthritis, Gouty; Chondrocalcinosis; Colchicine; Disease Models, Animal; Gout Suppressants; Inflammation | 2008 |
Experimental models of Peyronie's disease. Implications for new therapies.
Topics: Animals; Carrier Proteins; Colchicine; Disease Models, Animal; Fibrosis; Humans; Intracellular Signaling Peptides and Proteins; Male; Nitric Oxide Synthase; Penile Induration; Phosphodiesterase Inhibitors; Rats; Transforming Growth Factor beta; Tubulin Modulators | 2009 |
Role of melanocortin receptors in the regulation of gouty inflammation.
Topics: Allopurinol; Animals; Arthritis, Gouty; Colchicine; Crystallization; Disease Models, Animal; Gout Suppressants; Humans; Injections, Intra-Articular; Melanocortins; Mice; Receptors, Melanocortin; Uric Acid | 2011 |
Epidermolysis bullosa acquisita.
Topics: Adrenal Cortex Hormones; Animals; Antibodies, Monoclonal, Murine-Derived; Autoantibodies; Autoimmune Diseases; Colchicine; Collagen Type VII; Dapsone; Disease Models, Animal; Epidermolysis Bullosa Acquisita; Humans; Immunoglobulins, Intravenous; Mice; Rituximab | 2013 |
Beneficial drugs for liver diseases.
Topics: Adrenal Cortex Hormones; Animals; Colchicine; Curcumin; Disease Models, Animal; Drug Combinations; Glycyrrhizic Acid; Humans; Interferons; Liver Diseases; Nitric Oxide; Plant Extracts; Resveratrol; S-Adenosylmethionine; Silymarin; Stilbenes; Thalidomide | 2008 |
Clinical aspects of respiratory mucus.
Topics: Animals; Bronchi; Bronchitis; Calcium; Cilia; Colchicine; Cytochalasin B; Disease Models, Animal; Humans; Mucus; Organ Culture Techniques; Prostaglandins; Proteoglycans; Respiratory Physiological Phenomena; Sputum; Vasopressins | 1982 |
Changes in the collagen pathway in fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Colchicine; Collagen; Connective Tissue Diseases; Cross-Linking Reagents; Disease Models, Animal; Humans; Kinetics; Liver; Liver Cirrhosis; Lung; Organ Size; Ozone; Penicillamine; Proline; Pulmonary Fibrosis; Rats | 1985 |
Intestinal malabsorption in the experimental animal.
Topics: Amino Acids; Animals; Anura; Celiac Disease; Colchicine; Colonic Diseases; Disease Models, Animal; Dogs; Intestinal Absorption; Ischemia; Lactates; Malabsorption Syndromes; Mitosis; Nutrition Disorders; Rats; Swine; Triparanol | 1972 |
145 other study(ies) available for colchicine and Disease Models, Animal
| Article | Year |
|---|---|
[(2-Phenylindol-3-yl)methylene]propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in G(2)/M phase and apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; G2 Phase; Humans; Indoles; Mammary Neoplasms, Experimental; Mice; Molecular Structure; Nitriles; Stereoisomerism; Structure-Activity Relationship; Tubulin | 2007 |
Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Cell Proliferation; Disease Models, Animal; HL-60 Cells; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Neutrophils; Quinolines; Quinones; Respiratory Burst; Structure-Activity Relationship; Superoxides; Thiazines | 2008 |
Part II. Development of novel colchicine-derived immunosuppressants with improved pharmacokinetic properties.
Topics: Administration, Oral; Animals; Arthritis; Biological Availability; Colchicine; Disease Models, Animal; Immunosuppressive Agents; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Molecular Structure | 2012 |
Synthesis of thiophene-thiosemicarbazone derivatives and evaluation of their in vitro and in vivo antitumor activities.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Structure-Activity Relationship; Thiophenes; Thiosemicarbazones | 2015 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Development of novel NLRP3-XOD dual inhibitors for the treatment of gout.
Topics: Animals; Benzimidazoles; Benzoxazoles; Cell Line; Disease Models, Animal; Gout; Humans; Hyperuricemia; Interleukin-1beta; Liver; Mice; Monocytes; NLR Family, Pyrin Domain-Containing 3 Protein; Oxonic Acid; Rats; Structure-Activity Relationship; Synovial Membrane; Uric Acid; Xanthine Oxidase | 2020 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Topics: Administration, Oral; Adult; Animals; Antigens, CD; Bacteria; Behcet Syndrome; Butyrates; CD83 Antigen; Colchicine; Combined Modality Therapy; Dendritic Cells; Disease Models, Animal; Down-Regulation; Eubacterium; Fecal Microbiota Transplantation; Female; Gastrointestinal Microbiome; Herpes Simplex; Herpesvirus 1, Human; Humans; Immunoglobulins; Inflammation; Interleukin-17; Killer Cells, Natural; Male; Membrane Glycoproteins; Metagenome; Mice; Middle Aged; Random Allocation; Ribotyping; RNA, Ribosomal, 16S; Severity of Illness Index | 2021 |
Isovitexin alleviates acute gouty arthritis in rats by inhibiting inflammation via the TLR4/MyD88/NF-κB pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apigenin; Arthritis, Gouty; Colchicine; Disease Models, Animal; Inflammation; Male; Myeloid Differentiation Factor 88; NF-kappa B; Rats; Rats, Sprague-Dawley; Sulfonamides; Toll-Like Receptor 4 | 2021 |
Novel colchicine derivative CR42-24 demonstrates potent anti-tumor activity in urothelial carcinoma.
Topics: Animals; Carcinoma, Transitional Cell; Cell Line, Tumor; Colchicine; Disease Models, Animal; HeLa Cells; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Tubulin Modulators; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2022 |
The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis.
Topics: Animals; Arthritis, Gouty; Cells, Cultured; Colchicine; Disease Models, Animal; Macrophages; Malondialdehyde; Mice; NADPH Oxidase 4; NLR Family, Pyrin Domain-Containing 3 Protein; Peptides; Peroxidase; Reactive Oxygen Species; Treatment Outcome; Uric Acid | 2022 |
A microtubule-connexin-43 regulatory link suppresses arrhythmias and cardiac fibrosis in Duchenne muscular dystrophy mice.
Topics: Animals; Arrhythmias, Cardiac; Cardiomyopathies; Colchicine; Connexin 43; Disease Models, Animal; Dystrophin; Fibrosis; Mice; Mice, Inbred mdx; Microtubules; Muscular Dystrophy, Duchenne | 2022 |
Colchicine pre-treatment and post-treatment does not worsen bleeding or functional outcome after collagenase-induced intracerebral hemorrhage.
Topics: Animals; Brain Injuries; Cerebral Hemorrhage; Clinical Trials, Phase II as Topic; Colchicine; Collagenases; Disease Models, Animal; Fibrinolytic Agents; Inflammation; Rats | 2022 |
Beneficiary Effects of Colchicine on Inflammation and Fibrosis in a Mouse Model of Kidney Injury.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Caspase 1; Colchicine; Disease Models, Animal; Fibrosis; Inflammation; Interleukin-1; Kidney; Mice; Mice, Inbred C57BL; Renal Insufficiency, Chronic; Tubulin | 2023 |
Colchicine protects against the development of experimental abdominal aortic aneurysm.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Colchicine; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Oxidative Stress; Swine | 2023 |
Comparative transcriptome analysis to elucidate the therapeutic mechanism of colchicine against atrial fibrillation.
Topics: Animals; Atrial Fibrillation; Colchicine; Disease Models, Animal; Down-Regulation; Electrocardiography; Gene Expression Profiling; Gene Ontology; Heart Atria; Rats, Sprague-Dawley; Transcriptome; Up-Regulation | 2019 |
Appraisal of anti-gout potential of colchicine-loaded chitosan nanoparticle gel in uric acid-induced gout animal model.
Topics: Animals; Chitosan; Colchicine; Disease Models, Animal; Gout; Nanoparticles; Uric Acid | 2022 |
Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis.
Topics: alpha-Defensins; Animals; Anticholesteremic Agents; Aorta; Atherosclerosis; Cholesterol; Cholestyramine Resin; Colchicine; Diet, High-Fat; Disease Models, Animal; Female; Humans; Lipid Metabolism; Lipoproteins, LDL; Mice; Mice, Knockout, ApoE; Mice, Transgenic; Neutrophils | 2020 |
Plasma Metabolic Signature of Atherosclerosis Progression and Colchicine Treatment in Rabbits.
Topics: Animals; Atherosclerosis; Colchicine; Dietary Fats; Disease Models, Animal; Disease Progression; Humans; Metabolomics; Rabbits; Random Allocation | 2020 |
Colchicine prevents atrial fibrillation promotion by inhibiting IL-1β-induced IL-6 release and atrial fibrosis in the rat sterile pericarditis model.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Remodeling; Colchicine; Disease Models, Animal; Enzyme Activation; Fibrosis; Heart Atria; Heart Rate; Interleukin-1beta; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Male; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pericarditis; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Protective Effect of Colchicine on LPS-Induced Lung Injury in Rats via Inhibition of P-38, ERK1/2, and JNK Activation.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cell Line; Colchicine; Cytokines; Disease Models, Animal; Enzyme Activation; Leukocytes; Lipopolysaccharides; Lung; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Neutrophil Infiltration; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2020 |
Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.
Topics: Acylation; Adult; Aged; AMP-Activated Protein Kinases; Animals; Cell Line; Cohort Studies; Colchicine; Diabetes Mellitus; Disease Models, Animal; Echocardiography; Gene Expression Regulation; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Hexosamines; Humans; Hypertrophy, Right Ventricular; Male; Metabolome; Middle Aged; Mitochondria; Monocrotaline; Myocytes, Cardiac; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right | 2020 |
Centrally administered orexin prevents lipopolysaccharide and colchicine induced lethality via the vagal cholinergic pathway in a sepsis model in rats.
Topics: Animals; Cholinergic Neurons; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; Lipopolysaccharides; Male; Orexins; Rats; Rats, Sprague-Dawley; Sepsis; Survival Rate; Vagus Nerve | 2020 |
GEF-H1 Is Required for Colchicine Inhibition of Neutrophil Rolling and Recruitment in Mouse Models of Gout.
Topics: Actins; Animals; Colchicine; Disease Models, Animal; Gout; Leukocyte Rolling; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Knockout; Myosin Light Chains; Neutrophil Infiltration; Neutrophils; Rho Guanine Nucleotide Exchange Factors | 2020 |
Colchicine reduces lung injury in experimental acute respiratory distress syndrome.
Topics: Acute Lung Injury; Animals; Colchicine; Disease Models, Animal; Humans; Lung; Neutrophil Infiltration; Neutrophils; Oleic Acid; Rats; Respiratory Distress Syndrome | 2020 |
Orbitrap-MS-based untargeted metabolomics study on the therapeutic effect of colchicine on myocardial infarction.
Topics: Animals; Colchicine; Disease Models, Animal; Heart; Male; Metabolome; Metabolomics; Myocardial Infarction; Myocardium; Rats | 2021 |
CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease.
Topics: 5'-Nucleotidase; Acetaldehyde; Adenosine; Adenosine Triphosphate; Animals; Antigens, CD; Apyrase; Carbon Tetrachloride; Colchicine; Cytokines; Disease Models, Animal; Ethanol; Gene Knockdown Techniques; Hepatic Stellate Cells; Humans; Liver Diseases, Alcoholic; Mice, Inbred C57BL; Primary Cell Culture; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Tungsten Compounds | 2021 |
Pharmacokinetic and pharmacodynamic evaluation of nasal liposome and nanoparticle based rivastigmine formulations in acute and chronic models of Alzheimer's disease.
Topics: Administration, Intranasal; Alzheimer Disease; Animals; Area Under Curve; Biological Availability; Cholinesterase Inhibitors; Colchicine; Disease Models, Animal; Liposomes; Male; Maze Learning; Memory Disorders; Models, Biological; Nanoparticles; Rats; Rats, Wistar; Rivastigmine; Scopolamine | 2021 |
Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats.
Topics: Animals; Brain; Butyrates; Colchicine; Colon; Disease Models, Animal; Fatty Acids, Volatile; Lipopolysaccharides; Male; Nociception; Orexins; Permeability; Rats, Sprague-Dawley; Shock, Septic; Viscera | 2021 |
KLF4 Upregulation in Atherosclerotic Thoracic Aortas: Exploring the Protective Effect of Colchicine-based Regimens in a Hyperlipidemic Rabbit Model.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Colchicine; Disease Models, Animal; Drug Therapy, Combination; Fibric Acids; Hyperlipidemias; Kruppel-Like Factor 4; Male; Plaque, Atherosclerotic; Rabbits; Up-Regulation | 2022 |
Colchicine-Containing Nanoparticles Attenuates Acute Myocardial Infarction Injury by Inhibiting Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Calcium Carbonate; Colchicine; Cytokines; Disease Models, Animal; Inflammation; Myocardial Infarction; Nanoparticles; Rats | 2022 |
Interest of colchicine in the treatment of acute myocardial infarct responsible for heart failure in a mouse model.
Topics: Animals; Colchicine; Disease Models, Animal; Heart Failure; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Treatment Outcome; Tubulin Modulators | 2017 |
Colchicine Improves Survival, Left Ventricular Remodeling, and Chronic Cardiac Function After Acute Myocardial Infarction.
Topics: Animals; Colchicine; Disease Models, Animal; Male; Mice; Myocardial Infarction; Recovery of Function; Ventricular Remodeling | 2017 |
Colchicine attenuates renal fibrosis in a murine unilateral ureteral obstruction model.
Topics: Angiotensin II; Animals; Biomarkers; Cell Line; Cell Movement; Cell Survival; Colchicine; Disease Models, Animal; Fibroblasts; Fibrosis; Immunohistochemistry; Kidney Diseases; Male; Mice; Rats; rhoA GTP-Binding Protein; Ureteral Obstruction | 2017 |
Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension.
Topics: Animals; Cells, Cultured; Colchicine; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Membrane Proteins; Microtubules; Myocytes, Cardiac; Rats, Sprague-Dawley; Recovery of Function; Tubulin Modulators; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2017 |
The Effects of Colchicine-Impregnated Oxidized Regenerated Cellulose on Capsular Contracture.
Topics: Animals; Biomedical Engineering; Breast Implantation; Breast Implants; Cellulose, Oxidized; Colchicine; Contracture; Disease Models, Animal; Female; Rats; Rats, Wistar; Silicones | 2017 |
Role of N-acetyl galactosamine-4-SO
Topics: Acetylgalactosamine; Animals; Behcet Syndrome; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Interleukin-17; Lectins, C-Type; Ligands; Male; Mannose Receptor; Mannose-Binding Lectins; Mice; Pentoxifylline; Receptors, Cell Surface; Simplexvirus | 2017 |
Attenuation of neurobehavioral and neurochemical abnormalities in animal model of cognitive deficits of Alzheimer's disease by fermented soybean nanonutraceutical.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Behavior, Animal; Catalase; Cognition Disorders; Colchicine; Dietary Supplements; Disease Models, Animal; Fermented Foods; Glutathione; Glycine max; Hippocampus; Lipid Peroxidation; Male; Maze Learning; Memory; Neuroprotective Agents; Rats; Rats, Wistar; Soy Foods; Superoxide Dismutase | 2018 |
Liuweiwuling tablets attenuate BDL-induced hepatic fibrosis via modulation of TGF-β/Smad and NF-κB signaling pathways.
Topics: Animals; Colchicine; Collagen Type I; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gene Expression Regulation; Hepatic Stellate Cells; Liver Cirrhosis; Male; NF-kappa B; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad Proteins; Tablets; Transforming Growth Factor beta | 2018 |
A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimetabolites, Antineoplastic; Benzofurans; Carcinogenesis; Colchicine; Disease Models, Animal; Fluorouracil; Male; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tubulin; Tubulin Modulators | 2018 |
Cardioprotective Role of Colchicine Against Inflammatory Injury in a Rat Model of Acute Myocardial Infarction.
Topics: Animals; Anti-Inflammatory Agents; Caspase 1; Colchicine; Disease Models, Animal; Drug Therapy, Combination; Inflammasomes; Interleukin-10; Interleukin-18; Interleukin-1beta; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Rats, Wistar; Time Factors; Transforming Growth Factor beta1 | 2018 |
Protective Effect of Hyperforin on β Amyloid Protein Induced Apoptosis in PC12 Cells and Colchicine Induced Alzheimer's Disease: An Anti-oxidant and Anti-inflammatory Therapy.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; L-Lactate Dehydrogenase; Male; Malondialdehyde; Neuroprotective Agents; NF-kappa B; Oxidative Stress; PC12 Cells; Peptide Fragments; Phloroglucinol; Rats; Rats, Wistar; Signal Transduction; Terpenes | 2018 |
Combination of albendazole and 2-methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice.
Topics: 2-Methoxyestradiol; Albendazole; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colchicine; Colorectal Neoplasms; Cytotoxins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; HCT116 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Prostatic Neoplasms; Tubulin Modulators | 2013 |
Protective effects of colchicine in an experimental model of necrotizing enterocolitis in neonatal rats.
Topics: Animals; Animals, Newborn; Colchicine; Disease Models, Animal; Drug Evaluation, Preclinical; Enterocolitis, Necrotizing; Gout Suppressants; Ileum; Rats; Rats, Wistar | 2013 |
Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease.
Topics: Animals; Cells, Cultured; Colchicine; Collagen Type I; Connective Tissue Growth Factor; Cytoprotection; Disease Models, Animal; Enzyme Activation; Fibronectins; Fibrosis; Hypertension, Renal; Kidney; Male; Microtubules; Nephrectomy; Nephritis; Phosphorylation; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; rhoA GTP-Binding Protein; Smad3 Protein; Stress, Mechanical; Transfection; Transforming Growth Factor beta | 2013 |
The role of classical and alternative macrophages in the immunopathogenesis of herpes simplex virus-induced inflammation in a mouse model.
Topics: Animals; Behcet Syndrome; Colchicine; Disease Models, Animal; Inflammation; Interferon-gamma; Interleukin-4; Interleukin-6; Macrophages; Male; Mice; Mice, Inbred ICR; Pentoxifylline; Phenotype; Simplexvirus | 2014 |
[Effect of Panax notoginseng saponins on cytokines in liver fibrosis rats].
Topics: Animals; Carbon Tetrachloride; Colchicine; Cytokines; Disease Models, Animal; Gene Expression Regulation; Liver; Liver Cirrhosis, Experimental; Male; NF-kappa B; Panax notoginseng; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saponins; Tumor Necrosis Factor-alpha | 2013 |
Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.
Topics: Animals; Calcium Signaling; Cardiomegaly; Cardiomyopathies; Cells, Cultured; Colchicine; Disease Models, Animal; Excitation Contraction Coupling; Heart Failure; Humans; Kinesins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubules; Muscle Proteins; Myocytes, Cardiac; Nocodazole; Sarcolemma; Tubulin Modulators | 2014 |
Comparison of intravesical application of chondroitin sulphate and colchicine in rat protamine/lipopolysaccharide induced cystitis model.
Topics: Administration, Intravesical; Animals; Chondroitin Sulfates; Colchicine; Cystitis; Cystitis, Interstitial; Disease Models, Animal; Female; Lipopolysaccharides; Protamines; Rats; Rats, Wistar | 2014 |
Effects of naproxen on immune responses in a colchicine-induced rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Brain; Colchicine; Cytokines; Disease Models, Animal; Hydrocortisone; Lymphocytes; Male; Naproxen; Nitrites; Phagocytes; Plaque, Amyloid; Rats; Reactive Oxygen Species; Spleen; Time Factors; Tubulin Modulators | 2014 |
Discovery of structurally simplified analogs of colchicine as an immunosuppressant.
Topics: Animals; Arthritis; B-Lymphocytes; Carrageenan; Cell Proliferation; Colchicine; Concanavalin A; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Edema; Humans; Immunosuppressive Agents; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Molecular Structure; Structure-Activity Relationship; T-Lymphocytes; Zymosan | 2014 |
The effects of grape seed and colchicine on carbon tetrachloride induced hepatic damage in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Colchicine; Disease Models, Animal; Grape Seed Extract; Liver; Liver Diseases; Male; Rats; Rats, Wistar | 2014 |
Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
Topics: Animals; Axonal Transport; Brain-Derived Neurotrophic Factor; Cells, Cultured; Colchicine; CREB-Binding Protein; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; Interleukin-6; Male; Mice; Mice, Inbred ICR; Nociceptive Pain; Nocodazole; Protein Transport; Quinazolinones; Sciatic Nerve; Sensory Receptor Cells; Tubulin Modulators | 2014 |
Protective effects of colchicine in an experimental rat endometriosis model: histopathological evaluation and assessment of TNF-α levels.
Topics: Animals; Anti-Inflammatory Agents; Ascitic Fluid; Cell Proliferation; Colchicine; Cytoprotection; Disease Models, Animal; Down-Regulation; Endometriosis; Endometrium; Female; Rats, Wistar; Time Factors; Tumor Necrosis Factor-alpha | 2015 |
Colchicine suppresses atrial fibrillation in failing heart.
Topics: Action Potentials; Animals; Atrial Fibrillation; Blotting, Western; Colchicine; Collagen; Disease Models, Animal; Heart Failure; Ion Channels; Paclitaxel; Polymerase Chain Reaction; Proteins; Rabbits; RNA, Messenger; Signal Transduction | 2014 |
The effect of colchicine and low-dose methotrexate on intestinal ischemia/reperfusion injury in an experimental model.
Topics: Animals; Anti-Inflammatory Agents; Colchicine; Disease Models, Animal; Ileal Diseases; Intestines; Male; Methotrexate; Rats; Rats, Wistar; Reperfusion Injury | 2014 |
Protective effect of colchicine on ovarian ischemia-reperfusion injury: an experimental study.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Catalase; Colchicine; Cytoprotection; Disease Models, Animal; Female; Malondialdehyde; Ovarian Diseases; Ovary; Protein Carbonylation; Rats, Wistar; Reperfusion Injury; Time Factors; Torsion Abnormality | 2015 |
Effect of sodium alginate addition to resveratrol on acute gouty arthritis.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Chemokine CXCL10; Colchicine; Disease Models, Animal; Drug Therapy, Combination; Glucuronic Acid; Hexuronic Acids; Interleukin-1beta; Mice; Receptors, CCR5; Resveratrol; Stilbenes; Uric Acid | 2015 |
Colchicine derivative as a potential anti-glioma compound.
Topics: Animals; Antineoplastic Agents; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glioblastoma; Humans; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors; Tubulin; Xenograft Model Antitumor Assays | 2015 |
Effect of colchicine on polycystic ovary syndrome: an experimental study.
Topics: Androstenedione; Animals; C-Reactive Protein; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Female; Humans; Metformin; Ovarian Follicle; Ovary; Polycystic Ovary Syndrome; Random Allocation; Rats; Rats, Wistar; Testosterone; Tubulin Modulators | 2016 |
NMDA receptor is involved in neuroinflammation in intracerebroventricular colchicine-injected rats.
Topics: Alzheimer Disease; Animals; Cell Adhesion; Colchicine; Cytotoxicity, Immunologic; Disease Models, Animal; Humans; Immunomodulation; Inflammation Mediators; Infusions, Intraventricular; Male; Memantine; Mice; Neurogenic Inflammation; Neurotoxins; Phagocytosis; Rats; Receptors, N-Methyl-D-Aspartate | 2016 |
Role of cox-2 mediated neuroinflammation on the neurodegeneration and cognitive impairments in colchicine induced rat model of Alzheimer's Disease.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Cognition Disorders; Colchicine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Etoricoxib; Injections, Intraventricular; Male; Maze Learning; Neurodegenerative Diseases; Plaque, Amyloid; Pyridines; Rats; Sulfones; Time Factors | 2016 |
Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease.
Topics: Alzheimer Disease; Animals; Anxiety; Behavior, Animal; Colchicine; Corticosterone; Cyclooxygenase 2; Disease Models, Animal; Etoricoxib; Male; Memory; Pyridines; Rats; Sulfones | 2016 |
Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures.
Topics: Animals; Axons; Brain; Cells, Cultured; Colchicine; Dependovirus; Disease Models, Animal; Genetic Vectors; Green Fluorescent Proteins; Image Processing, Computer-Assisted; Male; Microscopy; Nerve Degeneration; Oxidopamine; Parkinsonian Disorders; Rats, Sprague-Dawley; Software | 2016 |
Thirst Is Associated with Suppression of Habenula Output and Active Stress Coping: Is there a Role for a Non-canonical Vasopressin-Glutamate Pathway?
Topics: Animals; Cats; Colchicine; Disease Models, Animal; Fear; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Habenula; Male; Neurons; Oncogene Proteins v-fos; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Signal Transduction; Stress, Psychological; Synapses; Thirst; Tubulin Modulators; Vasopressins; Water Deprivation | 2016 |
Colchicine aggravates coxsackievirus B3 infection in mice.
Topics: Animals; Colchicine; Coxsackievirus Infections; Disease Models, Animal; Enterovirus B, Human; Heart; Humans; Male; Mice; Mice, Inbred C3H; Myocarditis; Pancreas; Spleen; Treatment Outcome; Viral Load | 2016 |
Impairment of blood brain barrier is related with the neuroinflammation induced peripheral immune status in intracerebroventricular colchicine injected rats: An experimental study with mannitol.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Colchicine; Disease Models, Animal; Encephalitis; Hippocampus; Injections, Intraventricular; Interleukin-1beta; Leukocytes; Male; Mannitol; Mice; Phagocytosis; Rats; Reactive Oxygen Species; Spleen; Tumor Necrosis Factor-alpha | 2016 |
Coadministration of a Gloriosa superba extract improves the in vivo antitumoural activity of gemcitabine in a murine pancreatic tumour model.
Topics: Alkaloids; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Colchicine; Deoxycytidine; Disease Models, Animal; Female; Gemcitabine; Glycosides; Herb-Drug Interactions; Humans; Liliaceae; Mice, Inbred C57BL; Pancreas; Pancreatic Neoplasms; Phytotherapy; Plant Extracts; Seeds | 2016 |
Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys.
Topics: Animals; Apoptosis; Colchicine; Disease Models, Animal; Fibrosis; Kidney; Male; Mice; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Tubulin Modulators; Ureteral Obstruction | 2018 |
The effects of colchicine on the progression and regression of encapsulating peritoneal sclerosis.
Topics: Animals; Chlorhexidine; Colchicine; Dialysis Solutions; Disease Models, Animal; Female; Peritoneal Dialysis; Peritoneum; Rats; Rats, Wistar; Sclerosis; Tubulin Modulators | 2008 |
Mechanism of action of the stimulatory effect of apigenin-6-C-(2''-O-alpha-l-rhamnopyranosyl)-beta-L-fucopyranoside on 14C-glucose uptake.
Topics: Alloxan; Androstadienes; Animals; Biological Transport; Blood Glucose; Carbon Radioisotopes; Colchicine; Cycloheximide; Diabetes Mellitus, Experimental; Disaccharides; Disease Models, Animal; Dose-Response Relationship, Drug; Flavones; Flavonoids; Glucose; Hyperglycemia; Indoles; Insulin; Insulin Secretion; Magnoliopsida; Male; Muscle, Skeletal; Plant Leaves; Rats; Rats, Wistar; Tissue Distribution; Wortmannin | 2009 |
Biological impact of mechanical stimuli on tumor metastasis.
Topics: Animals; Cell Proliferation; Colchicine; Colonic Neoplasms; Disease Models, Animal; Mechanotransduction, Cellular; Mice; Neoplasm Metastasis; Stress, Mechanical | 2009 |
Colchicine attenuates inflammatory cell infiltration and extracellular matrix accumulation in diabetic nephropathy.
Topics: Animals; Cell Movement; Cells, Cultured; Chemokine CCL2; Colchicine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Extracellular Matrix; Fibronectins; Inflammation; Intercellular Adhesion Molecule-1; Macrophages; Rats; RNA, Messenger; Streptozocin; Tubulin Modulators | 2009 |
Adenosine regulation of microtubule dynamics in cardiac hypertrophy.
Topics: 2-Chloroadenosine; 5'-Nucleotidase; Adenosine; Animals; Cardiomegaly; Cells, Cultured; Colchicine; Disease Models, Animal; Mice; Mice, Inbred BALB C; Mice, Knockout; Microtubules; Myocardial Contraction; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Tubulin; Tubulin Modulators | 2009 |
Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Gouty; Biomarkers; Colchicine; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Gout Suppressants; Hyperalgesia; Interleukin-1; Male; Mice; Mice, Knockout; Neutrophil Infiltration; Receptors, Interleukin-1 Type I; Recombinant Fusion Proteins; Signal Transduction; Synovitis; Up-Regulation; Uric Acid | 2009 |
Topical use of colchicine to prevent spinal epidural fibrosis in rats.
Topics: Administration, Topical; Animals; Colchicine; Disease Models, Animal; Diskectomy; Epidural Space; Fibrosis; Laminectomy; Lumbar Vertebrae; Male; Rats; Rats, Sprague-Dawley | 2010 |
Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats.
Topics: Alzheimer Disease; Animals; Citrus; Cognition; Colchicine; Disease Models, Animal; Flavanones; Flavonoids; Humans; Male; Maze Learning; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar | 2010 |
Colchicine prolongs patency of myringotomy in an animal model.
Topics: Administration, Topical; Animals; Colchicine; Constriction, Pathologic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Ear, Middle; Follow-Up Studies; Gerbillinae; Myringoplasty; Otitis Media with Effusion; Postoperative Complications; Random Allocation; Rats; Risk Assessment; Time Factors; Treatment Outcome; Wound Healing | 2011 |
Repeated immobilization stress increases nur77 expression in the bed nucleus of the stria terminalis.
Topics: Analysis of Variance; Animals; Colchicine; Corticotropin-Releasing Hormone; Disease Models, Animal; Gene Expression Regulation; Immobilization; Male; Nuclear Receptor Subfamily 4, Group A, Member 1; Rats; Rats, Sprague-Dawley; RNA, Messenger; Septal Nuclei; Stress, Psychological; Time Factors; Tubulin Modulators | 2011 |
Decorin and colchicine as potential treatments for post-haemorrhagic ventricular dilatation in a neonatal rat model.
Topics: Animals; Animals, Newborn; Brain; Cerebral Hemorrhage; Cerebral Ventricles; Colchicine; Decorin; Dilatation, Pathologic; Disease Models, Animal; Gravity Sensing; Injections, Intraventricular; Longevity; Motor Activity; Random Allocation; Rats; Rats, Wistar; Reflex, Righting; Transforming Growth Factor beta | 2011 |
Comparison of CRF-immunoreactive neurons distribution in mouse and rat brains and selective induction of Fos in rat hypothalamic CRF neurons by abdominal surgery.
Topics: Abdomen; Amphibian Proteins; Animals; Brain; Cell Count; Colchicine; Corticotropin-Releasing Hormone; Disease Models, Animal; Gene Expression Regulation; Mice; Neurons; Oncogene Proteins v-fos; Peptide Hormones; Postoperative Complications; Radioimmunoassay; Rats; Species Specificity; Stress, Psychological; Tubulin Modulators; Urotensins | 2011 |
Nicotine evoked improvement in learning and memory is mediated through NPY Y1 receptors in rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amygdala; Analysis of Variance; Animals; Arcuate Nucleus of Hypothalamus; Arginine; Colchicine; Dentate Gyrus; Disease Models, Animal; Escape Reaction; Learning; Male; Maze Learning; Memory; Neuropeptide Y; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Septal Nuclei | 2012 |
The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit.
Topics: Animals; Basilar Artery; Colchicine; Disease Models, Animal; Male; Muscle, Smooth, Vascular; Rabbits; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2012 |
Effect of colchicine on myocardial injury induced by Trypanosoma cruzi in experimental Chagas disease.
Topics: Analysis of Variance; Animals; Chagas Disease; Colchicine; Collagen; Cricetinae; Disease Models, Animal; Female; Fibrosis; Heart Ventricles; Inflammation; Matrix Metalloproteinase 2; Myocarditis; Myocardium; Trypanosoma cruzi; Tubulin Modulators | 2012 |
Colchicine protects against hyperoxic lung injury in neonatal rats.
Topics: Acute Lung Injury; Animals; Animals, Newborn; Animals, Suckling; Antioxidants; Colchicine; Disease Models, Animal; Female; Glutathione Peroxidase; Hyperoxia; Interleukin-1beta; Male; Malondialdehyde; Oxidative Stress; Pulmonary Alveoli; Rats; Rats, Wistar; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2012 |
Colchicine protects dopaminergic neurons in a rat model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Catalepsy; Colchicine; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Dyskinesias; Injections, Intraperitoneal; Locomotion; Nerve Tissue Proteins; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tremor; Tubulin Modulators; Tyrosine 3-Monooxygenase | 2012 |
Comet-FISH studies for evaluation of genetic damage of citalopram in somatic cells of the mouse.
Topics: Administration, Oral; Animals; Bone Marrow; Centromere; Citalopram; Colchicine; Comet Assay; Disease Models, Animal; DNA Damage; DNA Probes; Dose-Response Relationship, Drug; In Situ Hybridization, Fluorescence; Male; Mice; Micronucleus Tests; Mitomycin; Mutagens | 2013 |
Type 1 diabetic mice are protected from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Bromobenzenes; Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver Injury; Colchicine; Diabetes Mellitus, Experimental; Disease Models, Animal; DNA; Drug Therapy, Combination; Liver; Liver Regeneration; Male; Mice; Microsomes, Liver; Proliferating Cell Nuclear Antigen | 2003 |
Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine.
Topics: Administration, Oral; Alanine Transaminase; Alcohol Deterrents; Animals; Bilirubin; Cholestasis, Extrahepatic; Colchicine; Collagen; Disease Models, Animal; Drug Combinations; gamma-Glutamyltransferase; Hydroxyproline; Injections, Intraperitoneal; Liver; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Liver Glycogen; Male; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar | 2003 |
Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat.
Topics: Animals; Arachnoid; Colchicine; Disease Models, Animal; Electroencephalography; Epilepsies, Partial; Male; Membranes; Microinjections; Neocortex; Rats; Rats, Wistar; Status Epilepticus; Time Factors | 2003 |
Seven cDNAs enriched following hippocampal lesion: possible roles in neuronal responses to injury.
Topics: Animals; Animals, Newborn; Blotting, Northern; Brain; Brain Injuries; Calcineurin; Cell Division; Cell Size; Cells, Cultured; Cloning, Molecular; Colchicine; Cyclosporine; Disease Models, Animal; DNA, Complementary; Enzyme Inhibitors; Gene Library; Hippocampus; Immunohistochemistry; In Situ Hybridization; Neurites; Neurons; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synapsins; Time Factors | 2003 |
Colchicine inhibits heterotopic ossification: experimental study in rabbits.
Topics: Animals; Calcification, Physiologic; Cell Proliferation; Colchicine; Disease Models, Animal; Female; Gout Suppressants; Ossification, Heterotopic; Osteoblasts; Rabbits; Radiography; Reference Values; Treatment Outcome; Ultrasonography | 2005 |
(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration.
Topics: Alkaloids; Alzheimer Disease; Aminoquinolines; Animals; Animals, Newborn; Apoptosis; Cerebellum; Cholinesterase Inhibitors; Colchicine; Cytoskeleton; Disease Models, Animal; Flow Cytometry; Glycogen Synthase Kinase 3; Heterocyclic Compounds, 4 or More Rings; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine | 2004 |
Neuronal degeneration and iNOS expression in experimental brain contusion following treatment with colchicine, dexamethasone, tirilazad mesylate and nimodipine.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Brain; Brain Injuries; Calcium Channel Blockers; Cell Survival; Colchicine; Dexamethasone; Disease Models, Animal; Encephalitis; Fluoresceins; Free Radical Scavengers; In Situ Nick-End Labeling; Male; Nerve Degeneration; Neuroprotective Agents; Nimodipine; Nitric Oxide; Nitric Oxide Synthase Type II; Organic Chemicals; Oxidative Stress; Pregnatrienes; Rats; Rats, Sprague-Dawley | 2005 |
Mechanical stretch-induced hypertrophy of neonatal rat ventricular myocytes is mediated by beta(1)-integrin-microtubule signaling pathways.
Topics: Angiotensin II; Animals; Animals, Newborn; Antibodies; Cardiomegaly; Cells, Cultured; Colchicine; Disease Models, Animal; In Vitro Techniques; Integrin beta1; Microscopy, Confocal; Microtubules; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Signal Transduction; Stress, Mechanical | 2006 |
Gout-associated uric acid crystals activate the NALP3 inflammasome.
Topics: Animals; Calcium Pyrophosphate; Carrier Proteins; Caspase 1; Cell Line; Cells, Cultured; Chondrocalcinosis; Colchicine; Disease Models, Animal; Gout; Humans; Inflammation; Interleukin-1; Macrophages; Mice; Neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein; Peritonitis; Receptors, Interleukin-1; Uric Acid | 2006 |
Colchicine in experimental alkaline burns of the rat esophagus: an old drug, a new indication?
Topics: Analysis of Variance; Animals; Burns, Chemical; Caustics; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; Esophagus; Fibrosis; Hydroxyproline; Protective Agents; Rats; Rats, Wistar; Sodium Hydroxide; Treatment Outcome; Wound Healing | 2006 |
Letter regarding article by Imazio et al, "colchicine in addition to conventional therapy for acute pericarditis".
Topics: Animals; Colchicine; Disease Models, Animal; Drug Therapy, Combination; Humans; Pericarditis; Reproducibility of Results; Research Design | 2006 |
Nerve degeneration is prevented by a single intraneural apotransferrin injection into colchicine-injured sciatic nerves in the rat.
Topics: Animals; Apoproteins; Axonal Transport; Axons; Colchicine; Cytoskeleton; Disease Models, Animal; Dose-Response Relationship, Drug; Immunohistochemistry; Microtubules; Myelin Basic Protein; Myelin Sheath; Nerve Tissue Proteins; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Sciatic Neuropathy; Transferrin; Treatment Outcome; Tubulin; Ubiquitin Thiolesterase; Wallerian Degeneration | 2006 |
Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cognition Disorders; Colchicine; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Injections, Intraventricular; Isoxazoles; Lipid Peroxidation; Male; Maze Learning; Memory; Naproxen; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Space Perception; Spatial Behavior; Sulfonamides; Time Factors | 2006 |
Retrograde axonal transport: a major transmission route of enterovirus 71 in mice.
Topics: Animals; Axonal Transport; Axons; Brain; Colchicine; Disease Models, Animal; Enterovirus; Enterovirus Infections; Lung; Mice; Mice, Inbred ICR; Spinal Cord; Survival Analysis; Viremia | 2007 |
Colchicine inhibits intimal hyperplasia and leukocyte VEGF expression in dogs.
Topics: Angioplasty, Balloon; Animals; Cardiovascular Agents; Colchicine; Disease Models, Animal; Dogs; Down-Regulation; Femoral Artery; Gene Expression; Hyperplasia; Leukocytes; Reverse Transcriptase Polymerase Chain Reaction; Tunica Intima; Vascular Endothelial Growth Factor A | 2008 |
[Effect of the microtubule depolymerization on mitochondria damage in rat myocardiocytes early after hypoxia].
Topics: Animals; Cell Hypoxia; Cells, Cultured; Colchicine; Disease Models, Animal; Hypoxia; Microtubules; Mitochondria, Heart; Random Allocation; Rats; Rats, Wistar | 2007 |
Urate crystals, inflammation, and colchicine.
Topics: Animals; Arthritis, Gouty; Colchicine; Disease Models, Animal; Gout; Gout Suppressants; History, 20th Century; Uric Acid | 2008 |
Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: a rationale for use of low-dose colchicine.
Topics: Acute Disease; Administration, Oral; Animals; Arthritis, Gouty; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; Gout Suppressants; Humans; In Vitro Techniques; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Neutrophils; Superoxides | 2008 |
[Pharmacological therapy of keloids in an athymic mouse model].
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Colchicine; Data Interpretation, Statistical; Disease Models, Animal; Glucocorticoids; Histological Techniques; Homozygote; Humans; Immunohistochemistry; Injections, Intraperitoneal; Keloid; Male; Mice; Mice, Nude; Nicardipine; Skin Transplantation; Time Factors; Transplantation, Heterologous; Triamcinolone | 2008 |
Hepatic collagen synthesis in a rat model of cirrhosis, and its modification by colchicine.
Topics: Animals; Colchicine; Collagen; Disease Models, Animal; Liver; Liver Cirrhosis, Experimental; Male; Procollagen-Proline Dioxygenase; Proline; Rats; Rats, Inbred Strains | 1981 |
Intradentate colchicine retards the development of amygdala kindling.
Topics: Amygdala; Animals; Colchicine; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Rats | 1982 |
Colchicine does not inhibit secretin-induced choleresis in rats exhibiting hyperplasia of bile ductules: evidence against a pivotal role of exocytic vesicle insertion.
Topics: Animals; Bicarbonates; Bile; Bile Ducts; Colchicine; Disease Models, Animal; Epithelium; Exocytosis; Hyperplasia; Male; Rats; Rats, Sprague-Dawley; Secretin | 1995 |
Inhibition of posterior capsule opacification: the effect of colchicine in a sustained drug delivery system.
Topics: Animals; Cataract; Cataract Extraction; Colchicine; Delayed-Action Preparations; Disease Models, Animal; Lens Capsule, Crystalline; Rabbits; Random Allocation | 1993 |
Effect of the microtubule-disrupting drug colchicine on rat cerulein-induced pancreatitis in comparison with the microtubule stabilizer taxol.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Colchicine; Disease Models, Animal; Gastrointestinal Agents; Male; Microscopy, Electron; Microscopy, Fluorescence; Microtubules; Paclitaxel; Pancreatic Juice; Pancreatitis; Rats; Rats, Wistar; Trypsin; Tubulin | 1995 |
Tolerance to phosgene is associated with a neutrophilic influx into the rat lung.
Topics: Adaptation, Physiological; Administration, Inhalation; Administration, Topical; Animals; Bronchoalveolar Lavage Fluid; Cell Movement; Colchicine; Dextrans; Disease Models, Animal; Drug Tolerance; Lung; Male; Neutrophils; Nitrogen Oxides; Oxidants; Oxygen; Ozone; Phosgene; Proteins; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Trachea | 1996 |
Effect of chronic colchicine administration on the myocardium of the aging spontaneously hypertensive rat.
Topics: Aging; Animals; Colchicine; Disease Models, Animal; Fibrosis; Heart; Hydroxyproline; Hypertension; Male; Muscle Contraction; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1997 |
Effect of colchicine and bisacodyl on rat intestinal transit and nitric oxide synthase activity.
Topics: Animals; Bisacodyl; Colchicine; Disease Models, Animal; Gastrointestinal Agents; Gastrointestinal Transit; Intestinal Mucosa; Ketotifen; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reference Values | 1997 |
Effect of Trasina, an ayurvedic herbal formulation, on experimental models of Alzheimer's disease and central cholinergic markers in rats.
Topics: Acetylcholine; Alzheimer Disease; Animals; Binding Sites; Choline O-Acetyltransferase; Cholinergic Antagonists; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; Frontal Lobe; Hippocampus; Ibotenic Acid; Male; Medicine, Ayurvedic; Memory Disorders; Phytotherapy; Plants, Medicinal; Rats; Rats, Wistar; Receptors, Muscarinic | 1997 |
Lack of therapeutic effect of colchicine on murine toxoplasmosis.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Colchicine; Diarrhea; Disease Models, Animal; Drug Combinations; Male; Mice; Pyrimethamine; Suspensions; Toxoplasmosis, Animal | 1998 |
Dopamine restores lung ability to clear edema in rats exposed to hyperoxia.
Topics: Acute Disease; Animals; Cell Membrane Permeability; Cells, Cultured; Colchicine; Disease Models, Animal; Dopamine; Epithelium; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Hyperoxia; Intracellular Fluid; Ion Transport; Macrophages, Alveolar; Male; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Sodium Channels; Sodium-Potassium-Exchanging ATPase | 1999 |
The effects of colchicine on a Peyronie's-like condition in an animal model.
Topics: Animals; Colchicine; Disease Models, Animal; Male; Penile Induration; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 1999 |
Progesterone in conjunction with estradiol has neuroprotective effects in an animal model of neurodegeneration.
Topics: Animals; Choline O-Acetyltransferase; Colchicine; Disease Models, Animal; Drug Therapy, Combination; Estradiol; Female; Hippocampus; Immunohistochemistry; Maze Learning; Neurodegenerative Diseases; Neuroprotective Agents; Progesterone; Rats; Rats, Long-Evans | 1999 |
[Changes of collagenase activity in immune hepatic fibrosis following pig's serum injection and therapeutic effect of HanDanGanLe].
Topics: Animals; Colchicine; Collagen; Collagenases; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Liver Cirrhosis, Experimental; Male; Rats; Rats, Wistar; Swine | 2000 |
Comparison of enterotoxicity between autumn crocus (Colchicum autumnale L.) and colchicine in the guinea pig and mouse : enterotoxicity in the guinea pig differs from that in the mouse.
Topics: Animals; Cattle; Cattle Diseases; Colchicine; Colchicum; Diarrhea; Disease Models, Animal; Guinea Pigs; Intestines; Male; Mice; Plants, Medicinal; Rats; Species Specificity | 2000 |
Antioxidant properties of colchicine in acute carbon tetrachloride induced rat liver injury and its role in the resolution of established cirrhosis.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; Lipid Peroxidation; Liver; Liver Cirrhosis; Luminescent Measurements; Male; Malondialdehyde; Rats; Thiobarbituric Acid Reactive Substances | 2000 |
Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area.
Topics: 3T3 Cells; Animals; Axonal Transport; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Colchicine; Corpus Striatum; Disease Models, Animal; Fibroblasts; Fluorescent Dyes; Hippocampus; Huntington Disease; In Situ Hybridization; Kainic Acid; Male; Mice; Microinjections; Neural Pathways; Neurons; Nitro Compounds; Propionates; Quinolinic Acid; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; RNA, Messenger; Stilbamidines; Up-Regulation | 2001 |
[Protection of hematopoietic cells against toxicity of anticancer agents by transfecting mdr1 gene into bone marrow cells].
Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Colchicine; Disease Models, Animal; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Genes, MDR; Humans; Mice; Transfection; Vincristine | 2000 |
Inhibition of the second phase of amyloidogenesis in a mouse model by a single-dose colchicine regimen.
Topics: Amyloidosis; Animals; Anti-Inflammatory Agents; Colchicine; Disease Models, Animal; Gout Suppressants; Male; Mice; Silver Nitrate; Time Factors | 2001 |
Danggui shaoyao san improve colchichine-induced learning acquisition impairment in rats.
Topics: Angelica sinensis; Animals; Avoidance Learning; Brain; Colchicine; Disease Models, Animal; Drugs, Chinese Herbal; Learning Disabilities; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain Threshold; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2001 |
Developing a model of colchicine neuropathy.
Topics: Animals; Biopsy, Needle; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gait; Injections, Intraperitoneal; Peripheral Nervous System Diseases; Probability; Rats; Rats, Sprague-Dawley; Reference Values; Risk Assessment; Sciatic Nerve | 2002 |
Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Division; CHO Cells; Colchicine; Cricetinae; Depsipeptides; Disease Models, Animal; Glioma; Humans; Leukemia P388; Leukemia, Lymphoid; Mice; Neoplasm Transplantation; Oligopeptides; Peptides, Cyclic; Protein Structure, Tertiary; Tubulin; Tumor Cells, Cultured; Vinca Alkaloids | 2002 |
Post-exposure local treatment of mice infected with rabies with two axonal flow inhibitors, colchicine and vinblastine.
Topics: Animals; Antibodies, Viral; Axonal Transport; Colchicine; Disease Models, Animal; Mice; Rabies; Rabies virus; Sciatic Nerve; Vinblastine | 1978 |
Concanavalin a cap formation on polymorphonuclear leukocytes of normal and beige (chediak-higashi) mice.
Topics: Animals; Binding Sites, Antibody; Cell Membrane; Chediak-Higashi Syndrome; Colchicine; Concanavalin A; Cyclic GMP; Disease Models, Animal; Leukocytes; Mice | 1975 |
Effects of antiinflammatory agents on the acute response of immune synovitis in rabbits.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Colchicine; Disease Models, Animal; Dose-Response Relationship, Immunologic; Glucuronidase; Indomethacin; Lysosomes; Methods; Niflumic Acid; Phenylbutazone; Prednisolone; Rabbits; Serum Albumin, Bovine; Synovitis; Triamcinolone Acetonide | 1977 |
Experimental inflammation induced by naturally occurring microcrystalline calcium salts.
Topics: Animals; Anti-Inflammatory Agents; Calcium; Calcium Phosphates; Carrageenan; Colchicine; Copper; Disease Models, Animal; Freund's Adjuvant; Indomethacin; Inflammation; Male; Phenylbutazone; Rats; Uric Acid | 1976 |
Experimental model of intracerebral infection with Cryptococcus neoformans: roles of phagocytes and opsonization.
Topics: Animals; Brain Diseases; Chloroquine; Colchicine; Cryptococcosis; Disease Models, Animal; Female; Mice; Opsonin Proteins; Phagocytes; Phagocytosis | 1992 |
A comparison of the anti-inflammatory activity of selective 5-lipoxygenase inhibitors with dexamethasone and colchicine in a model of zymosan induced inflammation in the rat knee joint and peritoneal cavity.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arthritis; Benzeneacetamides; Calcimycin; Colchicine; Dexamethasone; Dinoprostone; Disease Models, Animal; Hydroxamic Acids; Inflammation; Kinetics; Knee Joint; Leukocytes; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Peritonitis; Pyrazoles; Rats; Zymosan | 1991 |
["Push-pull" perfusion technic, a new approach applied to the study of transdentinal fluid].
Topics: Age Factors; Animals; Colchicine; Dentin; Dentin Permeability; Dentin Sensitivity; Disease Models, Animal; Extracellular Space; Ouabain; Perfusion; Rats | 1990 |
Colchicine prevents D-galactosamine-induced hepatitis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Calcium; Calcium-Transporting ATPases; Chemical and Drug Induced Liver Injury; Colchicine; Disease Models, Animal; Galactosamine; gamma-Glutamyltransferase; Glycogen; Lipid Peroxidation; Liver; Male; Rats; Rats, Inbred Strains | 1989 |
Effect of immunosuppression on epidermal defenses in a murine model of cutaneous candidiasis.
Topics: Animals; Candidiasis, Cutaneous; Cell Division; Colchicine; Cyclophosphamide; Disease Models, Animal; Epidermis; Female; Immunosuppression Therapy; Male; Mice; Mice, Inbred C57BL; Tetradecanoylphorbol Acetate | 1989 |
Crystal-induced inflammation in the rat subcutaneous air-pouch.
Topics: Animals; Anti-Inflammatory Agents; Calcium Pyrophosphate; Colchicine; Diphosphates; Disease Models, Animal; Inflammation; Leukotriene B4; Male; Neutrophils; Rats; Rats, Inbred Strains; Uric Acid | 1987 |
Studies of eicosanoid production in the air pouch model of synovial inflammation.
Topics: 6-Ketoprostaglandin F1 alpha; Air; Animals; Carrageenan; Colchicine; Dinoprostone; Disease Models, Animal; Female; Fluorouracil; Inflammation; Kinetics; L-Lactate Dehydrogenase; Neutrophils; Pertussis Vaccine; Prostaglandins; Prostaglandins E; Rats; Rats, Inbred Strains; Synovial Fluid | 1986 |
Morphologic demonstration of cytoplasmic ASSAM-related antigenic substance (CASSAM) by an immunoperoxidase technique.
Topics: Aging; Amyloid; Amyloidosis; Animals; Antigen-Antibody Complex; Colchicine; Cycloheximide; Cytoplasm; Disease Models, Animal; Immunoenzyme Techniques; Intestine, Small; Kidney; Liver; Mice; Microscopy, Electron; Serum Amyloid A Protein | 1985 |
Blockage of amyloid induction by colchicine in an animal model.
Topics: Amyloid; Amyloidosis; Animals; Caseins; Colchicine; Disease Models, Animal; Liver; Mice; Mice, Inbred CBA; Spleen | 1974 |
Colchicine inhibition of casein-induced amyloidosis in mice.
Topics: Amyloid; Amyloidosis; Animals; Caseins; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Microscopy, Polarization; Organ Size; Spleen; Time Factors | 1974 |
[Phagocytotic activity of the pigment epithelium after photocaogulation. (On the question of the origin of macrophages in the retina)].
Topics: Animals; Colchicine; Disease Models, Animal; Histological Techniques; Injections, Subcutaneous; Light Coagulation; Mitosis; Necrosis; Phagocytosis; Rabbits; Retina; Retinal Pigments | 1969 |
The control of corneal graft reaction by topical application of antimitotic agents (thio-tepa and colchicine).
Topics: Animals; Colchicine; Cornea; Corneal Transplantation; Disease Models, Animal; Graft Rejection; Histocompatibility; Mitosis; Ophthalmic Solutions; Postoperative Complications; Rabbits; Thiotepa; Time Factors; Transplantation Immunology; Transplantation, Homologous | 1971 |
Ultrastructural changes in skeletal muscle induced by colchicine.
Topics: Animals; Colchicine; Disease Models, Animal; Female; Injections, Intraperitoneal; Microscopy, Electron; Mitochondria, Muscle; Muscles; Myofibrils; Paralysis; Rats | 1971 |