colchiceine and Breast-Neoplasms

colchiceine has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for colchiceine and Breast-Neoplasms

Article	Year
Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors. Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:11 Demethylation of colchiceinamide (2) and its analogues (3-10) afforded a novel class of mammalian DNA topoisomerase II inhibitors (2a-10a) without displaying tubulin inhibitory activity. All target compounds inhibited the catalytic activity of topoisomerase II at drug concentrations at 100 microM. An in vitro cytotoxicity assay indicated that compounds 3a and 8a were strong and tissue-selective cytotoxic agents against the MCF-7 breast cancer cell line (IC50 = 0.36 and 0.48 microgram/mL, respectively) and the CAKI-1 renal cancer cell line (IC50 = 0.72 and 0.96 microgram/mL, respectively). Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Colchicine; Enzyme Inhibitors; Female; Humans; Indicators and Reagents; Kidney Neoplasms; Kinetics; Molecular Structure; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured	1998

Article

Year

Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors.

Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:11

Demethylation of colchiceinamide (2) and its analogues (3-10) afforded a novel class of mammalian DNA topoisomerase II inhibitors (2a-10a) without displaying tubulin inhibitory activity. All target compounds inhibited the catalytic activity of topoisomerase II at drug concentrations at 100 microM. An in vitro cytotoxicity assay indicated that compounds 3a and 8a were strong and tissue-selective cytotoxic agents against the MCF-7 breast cancer cell line (IC50 = 0.36 and 0.48 microgram/mL, respectively) and the CAKI-1 renal cancer cell line (IC50 = 0.72 and 0.96 microgram/mL, respectively).

Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Colchicine; Enzyme Inhibitors; Female; Humans; Indicators and Reagents; Kidney Neoplasms; Kinetics; Molecular Structure; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1998