coenzyme-q10 and Neuronal-Ceroid-Lipofuscinoses

coenzyme-q10 has been researched along with Neuronal-Ceroid-Lipofuscinoses* in 1 studies

Other Studies

1 other study(ies) available for coenzyme-q10 and Neuronal-Ceroid-Lipofuscinoses

Article	Year
Evaluation of the possible role of coenzyme Q10 and vitamin E in juvenile neuronal ceroid-lipofuscinosis (JNCL). Molecular aspects of medicine, 1997, Volume: 18 Suppl The juvenile type of neuronal ceroid lipofuscinosis (JNCL) is a recessively inherited, progressive neurodegenerative disease. In this study the levels of the antioxidant factors coenzyme Q10 (CoQ10) and vitamin E (alpha-tocopherol) were measured in plasma samples of 29 JNCL patients and compared to 48 healthy controls. A significant reduction of the coenzyme Q10 level (0.59 +/- 0.25 microgram/ml) was observed in JNCL patients when compared to control subjects (0.80 +/- 0.26 microgram/ml). The level of vitamin E was also reduced markedly in JNCL patients when compared to controls (10.4 +/- 4.1 and 12.1 +/- 4.5 micrograms/ml, respectively). The low levels of CoQ10 and vitamin E in JNCL patients may indicate an impaired antioxidant protection in this disease. Topics: Adolescent; Adult; Antioxidants; Child; Child, Preschool; Cholesterol; Coenzymes; Humans; Neuronal Ceroid-Lipofuscinoses; Ubiquinone; Vitamin E	1997

Article

Year

Evaluation of the possible role of coenzyme Q10 and vitamin E in juvenile neuronal ceroid-lipofuscinosis (JNCL).

Molecular aspects of medicine, 1997, Volume: 18 Suppl

The juvenile type of neuronal ceroid lipofuscinosis (JNCL) is a recessively inherited, progressive neurodegenerative disease. In this study the levels of the antioxidant factors coenzyme Q10 (CoQ10) and vitamin E (alpha-tocopherol) were measured in plasma samples of 29 JNCL patients and compared to 48 healthy controls. A significant reduction of the coenzyme Q10 level (0.59 +/- 0.25 microgram/ml) was observed in JNCL patients when compared to control subjects (0.80 +/- 0.26 microgram/ml). The level of vitamin E was also reduced markedly in JNCL patients when compared to controls (10.4 +/- 4.1 and 12.1 +/- 4.5 micrograms/ml, respectively). The low levels of CoQ10 and vitamin E in JNCL patients may indicate an impaired antioxidant protection in this disease.

Topics: Adolescent; Adult; Antioxidants; Child; Child, Preschool; Cholesterol; Coenzymes; Humans; Neuronal Ceroid-Lipofuscinoses; Ubiquinone; Vitamin E

1997