coenzyme-q10 and Glioma

Metabolic reprogramming in cancer cells, vs. non-cancer cells, elevates levels of reactive oxygen species (ROS) leading to higher oxidative stress. The elevated ROS levels suggest a vulnerability to excess prooxidant loads leading to selective cell death, a therapeutically exploitable difference. Co-enzyme Q

Topics: Animals; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Drug Delivery Systems; Female; Glioma; Humans; Lipids; Mice; Nanoparticles; NIH 3T3 Cells; Oxidation-Reduction; Pharmaceutical Preparations; Rats, Wistar; Superoxides; Ubiquinone

The present study showed the development of nanocapsules containing the association of the coenzyme Q10 and vitamin E acetate and the evaluation of their effect on in vitro cells culture of malignant glioma and melanoma. In order to investigate if nanocapsules are able to protect coenzyme Q10 from degradation under UVC radiation, a photostability study was carried out. For this, three concentrations of vitamin E acetate were evaluated (1%, 2%, or 3%). Nanocapsules presented suitable physicochemical characteristics and were able to protect coenzyme Q10 from photodegradation. In addition, this protection was influenced by higher vitamin E acetate concentrations, attributing to this oil an important role on coenzyme Q10 photostabilization. Regarding to in vitro citotoxicity assay, nanocapsules containing coenzyme Q10 and 2% vitamin E significantly reduced glioma and melanoma cell viability in 61% and 66%, respectively. In this sense, these formulations represent interesting platforms for the delivery of coenzyme Q10 and vitamin E acetate, presenting effect on the reduction of malignant cells viability.

Topics: Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Cell Survival; Drug Stability; Glioma; Humans; Melanoma; Nanocapsules; Photolysis; Polymers; Ubiquinone; Vitamin E; Vitamins