coelenterazine and Reperfusion-Injury

coelenterazine has been researched along with Reperfusion-Injury* in 1 studies

Other Studies

1 other study(ies) available for coelenterazine and Reperfusion-Injury

Article	Year
Protective effect of imidazolopyrazinone antioxidants on ischemia/reperfusion injury. Bioorganic & medicinal chemistry letters, 2003, Feb-24, Volume: 13, Issue:4 A series of 2-substituted 3,7-dihydroimidazolo[1,2-a]pyrazine-3-ones has been synthesized and evaluated for their antioxidant activity. Compounds 1-8 are inhibitors of AAPH-induced lipid peroxidation (in vitro) and excellent protectors against microvascular damages in ischemia/reperfusion (in vivo). Hence, the bicyclic structure typical of coelenterazine (luciferin) could be considered as a useful lead in medicinal chemistry. Topics: Amidines; Animals; Antioxidants; Capillary Permeability; Cricetinae; Firefly Luciferin; Imidazoles; Lipid Peroxidation; Microcirculation; Protective Agents; Pyrazines; Reperfusion Injury; Structure-Activity Relationship	2003

Article

Year

Protective effect of imidazolopyrazinone antioxidants on ischemia/reperfusion injury.

Bioorganic & medicinal chemistry letters, 2003, Feb-24, Volume: 13, Issue:4

A series of 2-substituted 3,7-dihydroimidazolo[1,2-a]pyrazine-3-ones has been synthesized and evaluated for their antioxidant activity. Compounds 1-8 are inhibitors of AAPH-induced lipid peroxidation (in vitro) and excellent protectors against microvascular damages in ischemia/reperfusion (in vivo). Hence, the bicyclic structure typical of coelenterazine (luciferin) could be considered as a useful lead in medicinal chemistry.

Topics: Amidines; Animals; Antioxidants; Capillary Permeability; Cricetinae; Firefly Luciferin; Imidazoles; Lipid Peroxidation; Microcirculation; Protective Agents; Pyrazines; Reperfusion Injury; Structure-Activity Relationship

2003