Compounds > cocaine

cocaine and Genetic Predisposition

cocaine has been researched along with Genetic Predisposition in 57 studies

Research

Studies (57)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (10.53)18.2507
2000's20 (35.09)29.6817
2010's25 (43.86)24.3611
2020's6 (10.53)2.80

Authors

AuthorsStudies
Li, RF; Lyu, Y; Mu, JB; Tian, FJ; Zheng, JP1
Cheng, J; Huang, C; Leng, S; Li, H; Liang, X; Lin, H; Niu, Y; Zhang, L; Zheng, Y1
Guo, H; He, Y; Li, J; Wang, F; Wu, T; Wu, Z; Yang, Y; Zheng, H1
Dai, YF; He, FS; Huang, CF; Leng, SG; Li, T; Li, XH; Niu, Y; Pan, ZF; Zheng, YX1
Cheng, J; Dai, Y; He, F; Leng, S; Li, X; Niu, Y; Pan, Z; Zheng, Y1
Clonfero, E; Mielzynska, D; Pavanello, S; Pulliero, A; Siwinska, E1
Cheng, J; Dai, YF; He, FS; Leng, SG; Li, B; Niu, Y; Pan, ZF; Sun, YF; Zhang, LY; Zheng, YX1
Cheng, J; Dai, YF; Leng, SG; Sun, YF1
Cheng, J; Dai, YF; Leng, SG; Li, B; Niu, Y; Pan, ZF; Zheng, YX1
Chang, SH; Chang, XW; Chen, Y; Li, YY; Lu, L; Muhai, JN; Shi, J; Sun, Y1
Bastos, DM; de Farias, KF; de Medeiros Alves, V; de Moura, EL; de Souza Figueiredo, EVM; Dos Santos, ACM; Dos Santos, BB; Dos Santos, BRC; E Silva, ACP; Nardi, AE; Neto, ABL1
Irvin, JW; Lee, CG; Lynch, WJ; Martini, M; Rissman, EF1
Bortolin, RH; Freitas, RCC; Hirata, M; Leyton, V; Miziara, ID; Pego, AMF; Santos, JR; Santos, PCJL; Tomaz, PRX; Yonamine, M1
Alballa, T; Boone, EL; Ma, L; Moeller, FG; Snyder, A1
Alasmari, F; Althobaiti, YS; Hammad, AM; Sari, Y1
Accoto, A; Andolina, D; Coassin, A; D'Amato, FR; Di Segni, M; Lizzi, AR; Luchetti, A; Luzi, C; Pascucci, T; Ventura, R1
Chadderdon, AM; Ferrario, CR; Jutkiewicz, EM; Kennedy, RT; Mabrouk, OS; Nesbitt, KM; Vollbrecht, PJ1
Arenas, C; Cabana-Domínguez, J; Cormand, B; Fernàndez-Castillo, N1
Dai, Y; Hu, R; Jia, P; Zhao, Z1
Escayg, A; Makinson, CD; Papale, LA; Purcell, RH; Sawyer, NT; Schroeder, JP; Weinshenker, D1
Almasy, L; Farrer, L; Gelernter, J; Koesterer, R; Kranzler, HR; Sherva, R; Zhao, H1
Kendler, KS; Lichtenstein, P; Maes, HH; Ohlsson, H; Sundquist, J; Sundquist, K1
Buxton, JA; Carleton, B; Gardy, J; Kuo, M; Omura, J; Purssell, R; Ross, C; Tzemis, D1
Bellivier, F; Besnard, A; Bolte, S; Caboche, J; Crettol, S; Daumas, S; Eap, CB; El Mestikawy, S; Giros, B; Gratton, A; Gutiérrez-Cuesta, J; Heck, N; Henrion, A; Herzog, E; Jamain, S; Lecca, S; Maldonado, R; Mameli, M; Marti, F; Martín-García, E; Moquin, L; Morel, LJ; Prado, MA; Prado, VF; Sakae, DY; Vanhoutte, P; Vorspan, F1
Chadderdon, AM; Ferrario, CR; Jutkiewicz, EM; Nobile, CW; Vollbrecht, PJ1
Butelman, ER; Kreek, MJ; Picetti, R; Valenza, M; Yuferov, V1
Berrettini, WH; Bloch, PJ; Dackis, CA; Ferraro, TN; Kampman, KM; Lohoff, FW; Nall, AH; O'Brien, CP; Oslin, DW; Pettinati, HM; Weller, AE1
Brady, K; Farrer, L; Gelernter, J; Kranzler, HR; Luo, X; Poling, J; Weiss, R; Yang, BZ; Zuo, L1
Boyle, AE; Gill, KJ1
Mormède, P; Ramos, A; Takahashi, RN; Terenina, E; Vendruscolo, JC; Vendruscolo, LF1
Meshul, CK; Meyer, PJ; Phillips, TJ1
Farrer, MJ; Hattori, N; Imai, H; Inoue, Y; Ishii, K; Ishiwata, K; Kachergus, JM; Kitagawa, M; Kono, S; Mizoguchi, K; Mizuno, Y; Nishioka, K; Obi, T; Ross, OA; Takanashi, M1
Alia-Klein, N; Biegon, A; Fowler, JS; Goldstein, RZ; Konova, AB; Maloney, T; Parvaz, MA; Shumay, E; Telang, F; Tomasi, D; Volkow, ND; Wang, GJ; Wang, R; Woicik, PA1
Brady, K; Cubells, JF; Farrer, LA; Gelernter, J; Ittiwut, C; Ittiwut, R; Kranzler, HR; Listman, JB; Oslin, D; Weiss, RD1
Ambrose-Lanci, LM; Berrettini, WH; Bloch, PJ; Clarke, TK; Dackis, CA; Ferraro, TN; Kampman, KM; Lohoff, FW; O'Brien, CP; Oslin, DW; Pettinati, HM1
Ambrosio, E; Botreau, F; Coria, SM; Del Olmo, N; Higuera-Matas, A; Miguéns, M; Olías, O1
Nestler, EJ1
Kosten, TR; Nielsen, DA; Reyes, JA; Simons, DD; Utrankar, A1
Lemeshow, S; Mash, DC; Papp, AC; Pinsonneault, JK; Sadee, W; Sullivan, D; Zhu, H1
Mayes, LC1
Barker, SA; Carrasco, GA; D'souza, DN; Damjanoska, KJ; Garcia, F; Muma, NA; Sullivan, NR; van De Kar, LD; Zhang, Y1
Breen, G; Castelo, A; Collier, D; Guindalini, C; Laranjeira, R; O'Gara, C; Vallada, H1
Aggen, SH; Gardner, CO; Gillespie, NA; Jacobson, K; Kendler, KS; Neale, MC; Prescott, CA1
Henricks, KK; Marley, RJ; Miner, LL1
Heavner, JE; Liu, J; Lutherer, LO; McIntyre, DC; Reigel, CE; Shi, B; Wang, MJ1
Belknap, JK; Buck, KJ; Crabbe, JC; Cunningham, CL; Phillips, TJ1
Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B1
Berrettini, WH; Ferraro, TN; Golden, GT; Jones, NL; Smith, GG; Snyder, RL1
Hall, FS; Sora, I; Uhl, GR1
Asher, J; Goodwin, FK1
Eberwine, JH; Mackler, SA1
Goldberg, SR; Marley, RJ; Witkin, JM1
Aroche, AP; Bau, CHD; Grassi-Oliveira, R; Grevet, EH; Kessler, FHP; Rovaris, DL; Sanvicente-Vieira, B; Schuch, JB; Stolf, AR; von Diemen, L1
Bau, CHD; Cupertino, RB; Grassi-Oliveira, R; Grevet, EH; Kessler, FHP; Müller, D; Pechansky, F; Roman, T; Rovaris, DL; Sanvicente-Vieira, B; Schuch, JB; Stolf, AR; Vitola, ES; von Diemen, L1
Bandeira, CE; Bau, CHD; Cupertino, RB; da Silva, BS; Grassi-Oliveira, R; Grevet, EH; Kappel, DB; Kessler, FHP; Rovaris, DL; Sanvicente-Vieira, B; Schuch, JB; von Diemen, L1
Akutagava-Martins, GC; Guimaraes, LS; Halpern, R; Kessler, FH; Müller, D; Pechansky, F; Roman, T; Stolf, AR; Szobot, CM1
Aroche, AP; Bau, CH; Bertuzzi, GP; Callegari-Jacques, SM; Grassi-Oliveira, R; Guimarães, LS; Mota, NR; Pezzi, JC; Rovaris, DL; Viola, TW1

Reviews

6 review(s) available for cocaine and Genetic Predisposition

ArticleYear
Common and distinguishing genetic factors for substance use behavior and disorder: an integrated analysis of genomic and transcriptomic studies from both human and animal studies.
    Addiction (Abingdon, England), 2022, Volume: 117, Issue:9

    Topics: Aldehyde Dehydrogenase, Mitochondrial; Animals; Cocaine; Epstein-Barr Virus Infections; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomics; Herpesvirus 4, Human; Humans; Nicotine; Polymorphism, Single Nucleotide; Substance-Related Disorders; Tobacco Use Disorder; Transcriptome

2022
Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis.
    Addiction biology, 2013, Volume: 18, Issue:4

    Topics: Adolescent; Black or African American; Case-Control Studies; Chi-Square Distribution; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Dopamine; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Haplotypes; Humans; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide; Receptor, Cannabinoid, CB1; Reward; United States

2013
Epigenetics of drug abuse: predisposition or response.
    Pharmacogenomics, 2012, Volume: 13, Issue:10

    Topics: Behavior, Addictive; Chromatin Assembly and Disassembly; Cocaine; DNA Methylation; Epigenesis, Genetic; Genetic Predisposition to Disease; Heroin; Humans; Receptors, Opioid, mu; Serotonin Plasma Membrane Transport Proteins; Substance-Related Disorders

2012
Identifying genes for alcohol and drug sensitivity: recent progress and future directions.
    Trends in neurosciences, 1999, Volume: 22, Issue:4

    Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Chromosome Mapping; Cocaine; Crosses, Genetic; Ethanol; Female; Forecasting; Genetic Predisposition to Disease; Humans; Lod Score; Male; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Mice, Knockout; Morphine; Pentobarbital; Quantitative Trait, Heritable; Substance Withdrawal Syndrome; Substance-Related Disorders

1999
Cocaine, reward, movement and monoamine transporters.
    Molecular psychiatry, 2002, Volume: 7, Issue:1

    Topics: Animals; Brain; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane Transport Proteins; Genetic Predisposition to Disease; Genetic Variation; Humans; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Mice, Knockout; Models, Neurological; Models, Psychological; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Reward; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters

2002
The molecular biology of addictive drugs.
    Molecular neurobiology, 1991,Spring, Volume: 5, Issue:1

    Topics: Alcoholism; Amphetamines; Animals; Behavior, Addictive; Brain; Cells, Cultured; Cocaine; Ethanol; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; Ion Channels; Mice; Narcotics; Nerve Tissue Proteins; Neurotransmitter Agents; Proto-Oncogenes; Rats; RNA; Signal Transduction; Substance-Related Disorders

1991

Other Studies

51 other study(ies) available for cocaine and Genetic Predisposition

ArticleYear
Interaction of heat shock protein 70 (HSP70) polymorphisms and occupational hazards increases the risk of hypertension in coke oven workers.
    Occupational and environmental medicine, 2018, Volume: 75, Issue:11

    Topics: Adult; Case-Control Studies; China; Coke; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; Hypertension; Industry; Male; Occupational Exposure; Polymorphism, Single Nucleotide; Regression Analysis

2018
Suboptimal DNA repair capacity predisposes coke-oven workers to accumulate more chromosomal damages in peripheral lymphocytes.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009, Volume: 18, Issue:3

    Topics: Adult; Biomarkers; Bleomycin; Case-Control Studies; Chi-Square Distribution; Coke; Cytokinesis; DNA Damage; DNA Repair; DNA-Binding Proteins; Female; Genetic Predisposition to Disease; Genotype; Humans; Incineration; Logistic Models; Lymphocytes; Male; Micronuclei, Chromosome-Defective; Occupational Exposure; Polymorphism, Single Nucleotide; Pyrenes; Risk; X-ray Repair Cross Complementing Protein 1

2009
Genetic variants of nucleotide excision repair genes are associated with DNA damage in coke oven workers.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Volume: 19, Issue:1

    Topics: Adult; Biomarkers, Tumor; China; Chromatography, High Pressure Liquid; Coke; Comet Assay; DNA Damage; DNA Repair; DNA-Binding Proteins; Genetic Predisposition to Disease; Genotype; Humans; Occupational Exposure; Polycyclic Aromatic Hydrocarbons; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Pyrenes; Xeroderma Pigmentosum Group A Protein

2010
[Effect of genetic polymorphisms of microsomal epoxide hydrolase on urinary 1-hydroxypyrene levels in coke oven workers].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2004, Volume: 22, Issue:4

    Topics: Coke; Cytochrome P-450 CYP1A1; DNA Damage; Epoxide Hydrolases; Genetic Predisposition to Disease; Glutathione Transferase; Humans; Male; Occupational Exposure; Polycyclic Aromatic Hydrocarbons; Polymorphism, Genetic; Pyrenes

2004
Effects of genetic polymorphisms of metabolic enzymes on cytokinesis-block micronucleus in peripheral blood lymphocyte among coke-oven workers.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2004, Volume: 13, Issue:10

    Topics: Acyltransferases; Adult; Coke; Cytokinesis; DNA Damage; Epoxide Hydrolases; Female; Genetic Predisposition to Disease; Genotype; Glutathione Transferase; Humans; Incineration; Lymphocytes; Male; Micronuclei, Chromosome-Defective; Middle Aged; Occupational Exposure; Polycyclic Aromatic Hydrocarbons; Polymorphism, Genetic

2004
Reduced nucleotide excision repair and GSTM1-null genotypes influence anti-B[a]PDE-DNA adduct levels in mononuclear white blood cells of highly PAH-exposed coke oven workers.
    Carcinogenesis, 2005, Volume: 26, Issue:1

    Topics: Benzopyrenes; Chromatography, High Pressure Liquid; Coke; DNA Adducts; DNA Repair; Genetic Predisposition to Disease; Genotype; Glutathione Transferase; Humans; Leukocytes, Mononuclear; Male; Occupational Exposure; Polycyclic Aromatic Hydrocarbons; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors

2005
[Association of XRCC1 polymorphisms and chromosomal damage levels in coke-oven workers].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2005, Volume: 39, Issue:3

    Topics: Adult; China; Chromosome Breakage; Coke; DNA-Binding Proteins; Female; Genetic Predisposition to Disease; Haplotypes; Humans; Lymphocytes; Male; Micronucleus Tests; Middle Aged; Occupational Diseases; Occupational Exposure; Polymorphism, Single Nucleotide; Pyrenes; X-ray Repair Cross Complementing Protein 1

2005
[Association between methylenetetrahydrofolate reductase gene haplotypes and the susceptibility of chromosomal damage in coke-oven workers].
    Wei sheng yan jiu = Journal of hygiene research, 2006, Volume: 35, Issue:4

    Topics: Air Pollutants, Occupational; Case-Control Studies; Coke; DNA Damage; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Micronuclei, Chromosome-Defective; Micronucleus Tests; Occupational Exposure; Polycyclic Aromatic Hydrocarbons; Polymorphism, Single Nucleotide; Pyrenes

2006
[Association between nucleotide excision repair gene polymorphisms and chromosomal damage in coke-oven workers].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2006, Volume: 40, Issue:6

    Topics: Adult; Alcohol Drinking; Coke; Comet Assay; Dihydroxydihydrobenzopyrenes; DNA Damage; DNA Repair; DNA Repair Enzymes; Extraction and Processing Industry; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Lymphocytes; Male; Micronucleus Tests; Middle Aged; Occupational Exposure; Polymorphism, Genetic; Smoking

2006
The Role of the IL-10 (-819C/T), TNFA (-308G/A) and ENOS (-786T/C) Polymorphisms of Impulsive and Aggressive Personality Traits in Cocaine/Crack Users.
    Neuroscience, 2022, 08-21, Volume: 498

    Topics: Aggression; Case-Control Studies; Cocaine; Cytokines; Genetic Predisposition to Disease; Genotype; Humans; Impulsive Behavior; Interleukin-10; Nitric Oxide; Nitric Oxide Synthase Type III; Personality; Polymorphism, Single Nucleotide

2022
Sex chromosome complement influences vulnerability to cocaine in mice.
    Hormones and behavior, 2020, Volume: 125

    Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Estradiol; Female; Genetic Predisposition to Disease; Genotype; Gonads; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Sex Characteristics; Sex Chromosomes

2020
SNPs from BCHE and DRD3 genes associated to cocaine abuse amongst violent individuals from Sao Paulo, Brazil.
    Forensic science international, 2020, Volume: 317

    Topics: Adult; Alleles; Brazil; Butyrylcholinesterase; Cocaine; Cocaine-Related Disorders; Female; Forensic Genetics; Genetic Predisposition to Disease; Genotype; Hair; Humans; Male; Polymorphism, Single Nucleotide; Racial Groups; Receptors, Dopamine D3; Violence

2020
Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.
    PloS one, 2021, Volume: 16, Issue:7

    Topics: Adult; Bayes Theorem; Brain; Cerebellum; Cocaine; Cocaine-Related Disorders; Corpus Callosum; Diffusion Tensor Imaging; Female; Genetic Association Studies; Genetic Predisposition to Disease; Glutamate Decarboxylase; Humans; Male; Middle Aged; White Matter; Young Adult

2021
Modulatory effects of Ampicillin/Sulbactam on glial glutamate transporters and metabotropic glutamate receptor 1 as well as reinstatement to cocaine-seeking behavior.
    Behavioural brain research, 2017, 08-14, Volume: 332

    Topics: Amino Acid Transport Systems, Acidic; Ampicillin; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Excitatory Amino Acid Agents; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Genetic Predisposition to Disease; Glutamic Acid; Male; Motor Activity; Neuroglia; Nucleus Accumbens; Prefrontal Cortex; Rats; Receptors, Metabotropic Glutamate; Self Administration; Sulbactam

2017
Sensitivity to cocaine in adult mice is due to interplay between genetic makeup, early environment and later experience.
    Neuropharmacology, 2017, Volume: 125

    Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Disease Models, Animal; Disease Susceptibility; Dopamine Uptake Inhibitors; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Mice, Inbred C57BL; Mice, Inbred DBA; Proto-Oncogene Proteins c-fos; Random Allocation; Reward; Spatial Behavior; Species Specificity

2017
Cocaine and desipramine elicit distinct striatal noradrenergic and behavioral responses in selectively bred obesity-resistant and obesity-prone rats.
    Behavioural brain research, 2018, 07-02, Volume: 346

    Topics: Animals; Body Temperature; Central Nervous System Agents; Cocaine; Corpus Striatum; Desipramine; Dopamine; Eating; Genetic Predisposition to Disease; Male; Motor Activity; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Obesity; Rats; Serotonin; Species Specificity

2018
MiR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in a dopaminergic cell model and may contribute to cocaine dependence.
    Translational psychiatry, 2018, 08-30, Volume: 8, Issue:1

    Topics: Case-Control Studies; Cocaine; Cocaine-Related Disorders; Dopaminergic Neurons; Down-Regulation; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; MicroRNAs

2018
ANCO-GeneDB: annotations and comprehensive analysis of candidate genes for alcohol, nicotine, cocaine and opioid dependence.
    Database : the journal of biological databases and curation, 2018, 01-01, Volume: 2018

    Topics: Alcoholism; Cocaine; Databases, Genetic; Genetic Predisposition to Disease; Genetic Variation; Humans; Internet; Molecular Sequence Annotation; Nicotine; Opioid-Related Disorders; Polymorphism, Single Nucleotide; User-Computer Interface

2018
Effects of an epilepsy-causing mutation in the SCN1A sodium channel gene on cocaine-induced seizure susceptibility in mice.
    Psychopharmacology, 2013, Volume: 228, Issue:2

    Topics: Animals; Cocaine; Dopamine; Dose-Response Relationship, Drug; Electrocardiography; Electroencephalography; Epilepsy; Fluorescent Antibody Technique; Genetic Predisposition to Disease; Male; Mice; Motor Activity; Mutation; NAV1.1 Voltage-Gated Sodium Channel; Seizures

2013
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
    Molecular psychiatry, 2014, Volume: 19, Issue:6

    Topics: Adult; Black or African American; CDC2 Protein Kinase; Cocaine; Cocaine-Related Disorders; Cyclin-Dependent Kinases; Dopamine Uptake Inhibitors; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotyping Techniques; Humans; Male; Nuclear Receptor Co-Repressor 2; Paranoid Disorders; Polymorphism, Single Nucleotide; United States; White People

2014
A population-based Swedish Twin and Sibling Study of cannabis, stimulant and sedative abuse in men.
    Drug and alcohol dependence, 2015, Apr-01, Volume: 149

    Topics: Adult; Central Nervous System Stimulants; Cocaine; Genetic Predisposition to Disease; Humans; Hypnotics and Sedatives; Male; Marijuana Abuse; Models, Statistical; Registries; Risk Factors; Siblings; Substance-Related Disorders; Sweden; Twins, Dizygotic; Twins, Monozygotic

2015
Genetic determinants of cocaine-associated agranulocytosis.
    BMC research notes, 2015, Jun-13, Volume: 8

    Topics: Adult; Agranulocytosis; ATP-Binding Cassette Transporters; British Columbia; Case-Control Studies; Cholesterol Side-Chain Cleavage Enzyme; Cocaine; Cocaine-Related Disorders; Female; Gene Expression; Genetic Predisposition to Disease; HLA-B27 Antigen; Humans; Levamisole; Male; Middle Aged; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Receptors, Adrenergic, beta-1

2015
The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens.
    Molecular psychiatry, 2015, Volume: 20, Issue:11

    Topics: Action Potentials; Adult; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Genetic Predisposition to Disease; Glutamic Acid; Humans; Mice; Mice, Transgenic; Middle Aged; Neurons; Nucleus Accumbens; Opioid-Related Disorders; Self Administration; Signal Transduction; Synaptic Potentials; Vesicular Glutamate Transport Proteins

2015
Pre-existing differences in motivation for food and sensitivity to cocaine-induced locomotion in obesity-prone rats.
    Physiology & behavior, 2015, Dec-01, Volume: 152, Issue:Pt A

    Topics: Animals; Body Weight; Cocaine; Conditioning, Operant; Diet; Dopamine Uptake Inhibitors; Feeding Behavior; Genetic Predisposition to Disease; Insulin; Male; Motivation; Motor Activity; Obesity; Rats, Sprague-Dawley

2015
Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration.
    Neuropharmacology, 2016, Volume: 105

    Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disease Models, Animal; Gene Expression; Genetic Predisposition to Disease; Male; Nucleus Accumbens; Opioid Peptides; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Opioid; RNA, Messenger; Self Administration; Species Specificity; Vasoconstrictor Agents

2016
Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:13

    Topics: Adult; Amino Acid Substitution; Black or African American; Brain Chemistry; Case-Control Studies; Catechol O-Methyltransferase; Cocaine; Cocaine-Related Disorders; DNA Mutational Analysis; Dopamine Uptake Inhibitors; Female; Genetic Predisposition to Disease; Genetic Testing; Genetic Variation; Genotype; Haplotypes; Humans; Male; Methionine; Middle Aged; Polymorphism, Genetic; Valine

2008
Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:6

    Topics: Black or African American; Case-Control Studies; Cluster Analysis; Cocaine; Cocaine-Related Disorders; Family; Genetic Predisposition to Disease; Haplotypes; Humans; Linkage Disequilibrium; Paranoid Disorders; Polymorphism, Single Nucleotide; Receptor, Cannabinoid, CB1; Regression Analysis; Sequence Analysis, DNA; United States; White People

2009
Genetic influences on drug-induced psychomotor activation in mice.
    Genes, brain, and behavior, 2008, Volume: 7, Issue:8

    Topics: Animals; Binding, Competitive; Chromosome Mapping; Cocaine; DNA Mutational Analysis; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Resistance; Ethanol; Female; Genetic Predisposition to Disease; Genetic Testing; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Morphine; Motor Activity; Presynaptic Terminals; Psychomotor Agitation; Species Specificity; Substance-Related Disorders; Synaptosomes

2008
Marker-assisted dissection of genetic influences on motor and neuroendocrine sensitization to cocaine in rats.
    Genes, brain, and behavior, 2009, Volume: 8, Issue:3

    Topics: Animals; Behavior, Animal; Biomarkers; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Corticosterone; Dopamine Uptake Inhibitors; Female; Genetic Predisposition to Disease; Genotype; Hypothalamo-Hypophyseal System; Male; Motor Activity; Neurosecretory Systems; Quantitative Trait Loci; Rats; Rats, Inbred Lew; Rats, Inbred SHR; Sex Characteristics; Species Specificity

2009
Ethanol- and cocaine-induced locomotion are genetically related to increases in accumbal dopamine.
    Genes, brain, and behavior, 2009, Volume: 8, Issue:3

    Topics: Alcohol-Induced Disorders, Nervous System; Animals; Central Nervous System Depressants; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Ethanol; Extracellular Fluid; Genetic Predisposition to Disease; Male; Mice; Mice, Mutant Strains; Microdialysis; Motor Activity; Neural Pathways; Nucleus Accumbens; Substance-Related Disorders; Ventral Tegmental Area

2009
Expanding the clinical phenotype of SNCA duplication carriers.
    Movement disorders : official journal of the Movement Disorder Society, 2009, Sep-15, Volume: 24, Issue:12

    Topics: Adult; Aged; alpha-Synuclein; Brain; Carbon Isotopes; Chromosome Mapping; Cocaine; Family Health; Female; Fluorodeoxyglucose F18; Gene Dosage; Gene Duplication; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Parkinson Disease; Phenotype; Positron-Emission Tomography; Raclopride; REM Sleep Behavior Disorder; Sensory Thresholds; Smell; Young Adult

2009
Gene x disease interaction on orbitofrontal gray matter in cocaine addiction.
    Archives of general psychiatry, 2011, Volume: 68, Issue:3

    Topics: Adult; Alcoholism; Alleles; Atrophy; Brain; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Frontal Lobe; Genetic Predisposition to Disease; Genotype; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Monoamine Oxidase; Organ Size; Polymorphism, Genetic; Prefrontal Cortex; Smoking; Tobacco Use Disorder

2011
Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2011, Volume: 156B, Issue:6

    Topics: Black or African American; Case-Control Studies; Catechol O-Methyltransferase; Cocaine; Cocaine-Related Disorders; Dopamine; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Norepinephrine; Paranoid Disorders; Polymorphism, Single Nucleotide; White People

2011
Genetic differences in the modulation of accumbal glutamate and γ-amino butyric acid levels after cocaine-induced reinstatement.
    Addiction biology, 2013, Volume: 18, Issue:4

    Topics: Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Electrophoresis, Capillary; Extinction, Psychological; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamic Acid; Microdialysis; Nucleus Accumbens; Rats; Rats, Inbred F344; Rats, Inbred Lew; Recurrence; Self Administration; Sodium Chloride; Species Specificity

2013
Hidden switches in the mind.
    Scientific American, 2011, Volume: 305, Issue:6

    Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Depression; Diseases in Twins; Environment; Epigenesis, Genetic; Female; Gene Expression; Genetic Predisposition to Disease; Humans; Male; Maternal Behavior; Mental Disorders

2011
Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction.
    Translational psychiatry, 2013, Jan-22, Volume: 3

    Topics: Adult; Case-Control Studies; Cocaine; Cocaine-Related Disorders; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Overdose; Epistasis, Genetic; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Haplotypes; Humans; Logistic Models; Male; Middle Aged; Minisatellite Repeats; Odds Ratio; Polymorphism, Genetic; Prefrontal Cortex; Putamen; Receptors, Dopamine D2

2013
Genetics of childhood disorders: LV. Prenatal drug exposure.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2003, Volume: 42, Issue:10

    Topics: Adult; Central Nervous System; Central Nervous System Stimulants; Child; Child Behavior Disorders; Child, Preschool; Cocaine; Dopamine Uptake Inhibitors; Embryonic and Fetal Development; Ethanol; Female; Genetic Predisposition to Disease; Humans; Infant; Infant, Newborn; Pregnancy; Prenatal Exposure Delayed Effects

2003
Estrogen treatment increases the levels of regulator of G protein signaling-Z1 in the hypothalamic paraventricular nucleus: possible role in desensitization of 5-hydroxytryptamine1A receptors.
    Neuroscience, 2004, Volume: 127, Issue:2

    Topics: Adaptation, Physiological; Animals; Brain Chemistry; Cocaine; Depressive Disorder; Dose-Response Relationship, Drug; Drug Resistance; Estrogens; Female; Genetic Predisposition to Disease; GTPase-Activating Proteins; Male; Membrane Proteins; Nerve Tissue Proteins; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; RGS Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists; Sex Characteristics; Up-Regulation

2004
A GSTP1 functional variant associated with cocaine dependence in a Brazilian population.
    Pharmacogenetics and genomics, 2005, Volume: 15, Issue:12

    Topics: Adult; Ambulatory Care; Brazil; Cocaine; Cocaine-Related Disorders; Genetic Predisposition to Disease; Genetic Variation; Glutathione S-Transferase pi; Humans; Male

2005
Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulants.
    Psychological medicine, 2007, Volume: 37, Issue:7

    Topics: Adolescent; Adult; Cannabis; Central Nervous System Stimulants; Child; Cocaine; Diseases in Twins; Ethanol; Genetic Predisposition to Disease; Humans; Illicit Drugs; Longitudinal Studies; Male; Models, Statistical; Nicotiana; Registries; Risk Factors; Social Environment; Substance-Related Disorders; Twins, Dizygotic; Twins, Monozygotic; Virginia

2007
Differential cocaine sensitivity between two closely related substrains of C57BL mice.
    Psychopharmacology, 1997, Volume: 132, Issue:2

    Topics: Animals; Cocaine; Female; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred C57BL; Motor Activity; Narcotics; Seizures

1997
Two genetically selected strains of rats exhibit hypersensitivity or resistance to cocaine-induced fatal arrhythmias.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Cocaine; Dose-Response Relationship, Drug; Drug Hypersensitivity; Drug Tolerance; Electrocardiography; Female; Genetic Predisposition to Disease; Heart Arrest; Hemodynamics; Male; Myocardium; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Sensitivity and Specificity; Vasoconstrictor Agents

1999
Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:4-5

    Topics: Animals; Arrhythmias, Cardiac; Cocaine; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Male; Phenotype; Rats; Rats, Sprague-Dawley; Seizures

2000
Acute cocaine-induced seizures: differential sensitivity of six inbred mouse strains.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 24, Issue:3

    Topics: Animals; Brain; Cerebral Cortex; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Seizures

2001
From the alcohol, Drug Abuse, and Mental Health Administration.
    JAMA, 1991, Dec-25, Volume: 266, Issue:24

    Topics: Antidepressive Agents, Tricyclic; Cocaine; Depressive Disorder; Genetic Predisposition to Disease; Humans; Life Change Events; United States; United States Substance Abuse and Mental Health Services Administration

1991
Genetic factors influence changes in sensitivity to the convulsant properties of cocaine following chronic treatment.
    Brain research, 1991, Feb-22, Volume: 542, Issue:1

    Topics: Animals; Cocaine; Drug Resistance; Genetic Predisposition to Disease; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Seizures; Time Factors

1991
Association of CHRNA5 Gene Variants with Crack Cocaine Addiction.
    Neuromolecular medicine, 2020, Volume: 22, Issue:3

    Topics: Adult; Alleles; Case-Control Studies; Cocaine-Related Disorders; Computer Simulation; Crack Cocaine; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Haplotypes; Humans; Male; Nerve Tissue Proteins; Polymorphism, Single Nucleotide; Receptors, Nicotinic; Risk; Structure-Activity Relationship; Young Adult

2020
Effects of DRD2 splicing-regulatory polymorphism and DRD4 48 bp VNTR on crack cocaine addiction.
    Journal of neural transmission (Vienna, Austria : 1996), 2019, Volume: 126, Issue:2

    Topics: Adult; Cocaine-Related Disorders; Crack Cocaine; Cross-Sectional Studies; Female; Genetic Predisposition to Disease; Humans; Male; Minisatellite Repeats; Polymorphism, Genetic; Receptors, Dopamine D2; Receptors, Dopamine D4; Sex Factors; Young Adult

2019
The association between SYT1-rs2251214 and cocaine use disorder further supports its role in psychiatry.
    Progress in neuro-psychopharmacology & biological psychiatry, 2019, 08-30, Volume: 94

    Topics: Adult; Case-Control Studies; Cocaine-Related Disorders; Crack Cocaine; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Polymorphism, Single Nucleotide; Synaptotagmin I; Young Adult

2019
Crack cocaine users show differences in genotype frequencies of the 3' UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3).
    Neuropsychobiology, 2014, Volume: 70, Issue:1

    Topics: 3' Untranslated Regions; Adult; Cocaine-Related Disorders; Crack Cocaine; Depression; DNA Mutational Analysis; Dopamine Plasma Membrane Transport Proteins; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Male; Minisatellite Repeats; Phenotype; Young Adult

2014
Corticosteroid receptor genes and childhood neglect influence susceptibility to crack/cocaine addiction and response to detoxification treatment.
    Journal of psychiatric research, 2015, Volume: 68

    Topics: Adult; Child; Child Abuse; Cocaine-Related Disorders; Crack Cocaine; Cross-Sectional Studies; Epistasis, Genetic; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Inactivation, Metabolic; Male; Mental Status Schedule; Polymorphism, Single Nucleotide; Receptors, Steroid; Young Adult

2015