cocaine has been researched along with Drug Withdrawal Symptoms in 850 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 112 (13.18) | 18.7374 |
| 1990's | 283 (33.29) | 18.2507 |
| 2000's | 241 (28.35) | 29.6817 |
| 2010's | 186 (21.88) | 24.3611 |
| 2020's | 28 (3.29) | 2.80 |
| Authors | Studies |
|---|---|
| Preston, CJ; Wagner, JJ | 1 |
| Chamberlain, JM; Coralic, Z; Kapur, J; Olson, KR; Overbeek, D; Silbergleit, R | 1 |
| Allocca, G; Cai, L; Chen, B; Ding, W; Dong, Y; Fang, J; Gorczyca, MT; Guo, R; Hines, RL; Huang, YH; Ozsoy, S; Tseng, GC; Wang, Y; Yan, R | 1 |
| Milovanovic, M; Stefanik, MT; Wolf, ME; Wong, B; Zimbelman, AR | 1 |
| Li, MJ; Shoptaw, SJ | 1 |
| Bristot, G; Halpern, SC; Kapczinski, F; Kessler, FHP; Ornell, F; Pechansky, F; Rebelatto, FP; Roglio, VS; Scherer, JN; Schuch, JB; Sordi, AO; von Diemen, L | 1 |
| Dong, Y; Freyberg, Z; He, Y; Li, KL; Wang, J; Wang, YQ | 1 |
| Stephenson, RJ; Toth, I | 1 |
| Dietz, DM; Gancarz, AM; Gobira, PH; Lepack, AE; Martin, JA; Maze, I; Mitra, S; Neve, RL; Ramakrishnan, A; Shen, L; Stewart, AF; Wang, ZJ; Werner, CT | 1 |
| Caccamise, A; Corbett, CM; Loweth, JA; Munshi, S; Rosenkranz, JA; Wolf, ME | 1 |
| Noble, F | 1 |
| Bernat, N; Inbar, D; Inbar, K; Kupchik, YM; Levi, LA; Odesser, T | 1 |
| Butelman, ER; Kreek, MJ; Reed, B; Valenza, M; Windisch, KA | 1 |
| Denomme, WJ; Shane, MS | 1 |
| Carr, CC; Ferrario, CR; Robinson, TE | 1 |
| Filip, M; Frankowska, M; Fumagalli, F; Sanak, M; Smaga, I; Wydra, K | 1 |
| Andersen, ML; Dokkedal-Silva, V; Galduróz, JCF; Tufik, S | 1 |
| Dhingra, I; Le, TM; Li, CR; Wang, W; Zhang, S; Zhornitsky, S | 1 |
| Gasparyan, A; Manzanares, J; Miñarro, J; Navarrete, F; Rodríguez-Arias, M | 1 |
| Gil-Miravet, I; Guarque-Chabrera, J; Miquel, M; Nicolas, C; Sanchez-Hernandez, A; Solinas, M | 1 |
| Amiad, L; Azriel, M; Bingor, A; Yaka, R | 1 |
| Ahdoot, HL; Bareli, T; Barnea, R; Ben-Moshe, H; Maayan, R; Roska, P; Warhaftig, G; Weizman, A; Yadid, G | 1 |
| Grad, E; Thornton, C; Yaka, R | 1 |
| Bakhti-Suroosh, A; Lynch, WJ; Towers, EB | 1 |
| Aguilar, MA; Ledesma, JC; Manzanedo, C | 1 |
| Barger, BD; Chiu, AS; Elias, KN; Fabella, AM; Holder, KN; Huerta Sanchez, LL; Jimenez Chavez, CL; Kang, MC; Kippin, TE; Shin, CB; Szumlinski, KK | 1 |
| Barbosa-Méndez, S; López-Morado, C; Salazar-Juárez, A | 1 |
| Cui, C; Ge, F; Li, Y; Liu, S; Sun, X; Wang, J; Wang, N; Wang, X; Wang, Z; Yang, M | 1 |
| Althobaiti, YS; Das, SC; Hammad, AM; Sari, Y | 1 |
| Banks, ML; Negus, SS | 2 |
| Frantz, KJ; Li, C | 1 |
| Aguilar, MA; Arenas, MC; Ledesma, JC; Manzanedo, C; Miñarro, J; Penalva, C; Rodríguez-Arias, M | 1 |
| Dias, N; Janes, AC; Lukas, SE; McCarthy, JM; Shepherd, JM; Zuo, CS | 1 |
| Shin, CB; Szumlinski, KK | 1 |
| Caffino, L; Fumagalli, F; Giannotti, G; Messa, G; Mottarlini, F | 1 |
| Milovanovic, M; Spainhour, JCG; Stefanik, MT; Werner, CT; Wolf, ME | 1 |
| Carelli, RM; Haake, RM; Wang, X; West, EA | 1 |
| Bading, H; Baur, K; Bengtson, CP; Bernardi, RE; Hach, A; Spanagel, R | 1 |
| Anier, K; Herodes, K; Kalda, A; Kipper, K; Timmusk, T; Urb, M; Zharkovsky, A | 1 |
| Bobadilla, AC; Heinsbroek, JA; Kalivas, PW; Neuhofer, D; Roberts-Wolfe, D | 1 |
| Aricò, E; Bussone, S; Carola, V; Casella, P; Catale, C; Chiurchiù, V; D'Argenio, A; Di Sabato, P; Guatteo, E; Lo Iacono, L; Maccarrone, M; Martini, A; Mercuri, NB; Perrone, F; Puglisi-Allegra, S; Troisi, A; Valzania, A; Viscomi, MT | 1 |
| Bading, H; Buechler, E; Cannella, N; Hemstedt, T; Lissek, T; Oliveira, AMM; Spanagel, R | 1 |
| Mameli, M; Meye, FJ; Nuno-Perez, A; Tan, D | 1 |
| Akumuo, RC; España, RA; Gao, WJ; Li, YC; Yan, CX; Zhang, YX | 1 |
| Highgate, Q; Schenk, S | 1 |
| Anderson, BJ; Bailey, GL; Kenney, SR; Stein, MD | 1 |
| Bedi, G; Carpenter, K; Evans, SM; Foltin, RW; Haney, M | 1 |
| Bernstein, I; Greer, TL; Northrup, TF; Tillitski, J; Trivedi, MH; Walker, R | 1 |
| Anier, K; Herodes, K; Kalda, A; Kipper, K; Matsalu, T; Niinep, K; Timmusk, T; Urb, M; Zharkovsky, A | 1 |
| Barbosa Méndez, S; Salazar-Juárez, A | 1 |
| Cahill, ME; Calipari, ES; Damez-Werno, DM; Defilippi, P; Dietz, DM; Gancarz, AM; Godino, A; Hurd, YL; Jlayer, Z; Kenny, PJ; Landry, JA; Nestler, EJ; Neve, RL; Peck, EG; Rabkin, J; Salery, M; Smith, ACW; Werner, CT | 1 |
| Blurton-Jones, M; Harvey, E; Kennedy, PJ | 1 |
| Adamczyk, P; Bystrowska, B; Filip, M; Fuxe, K; Moniczewski, A; Zaniewska, M | 1 |
| He, C; Hong, F; Liu, X; Yang, S | 1 |
| Damaj, MI; Ignatowska-Jankowska, BM; Lichtman, AH; Muldoon, PP | 1 |
| Chen, B; Dong, Y; Huang, YH; Ma, YY; Schlüter, OM; Wang, X; Wang, Y | 1 |
| Cahill, ME; Christoffel, DJ; Golden, SA; Loweth, JA; Marinelli, M; Penzes, P; Russo, SJ; Wang, X; Werner, CT; Wolf, ME; Xie, Z | 1 |
| Caffino, L; Cassina, C; Cervo, L; Di Clemente, A; Fumagalli, F; Giannotti, G; Moro, F; Orrù, A; Racagni, G | 1 |
| Goldman, D; Hodgkinson, C; Hu, Y; Seo, D; Sinha, R; Xu, K | 1 |
| Brown, TE; Dong, Y; Graziane, NM; Guo, C; Huang, YH; Ishikawa, M; Lee, BR; Lobo, MK; Ma, YY; Nestler, EJ; Neumann, PA; Otaka, M; Schlüter, OM; Sesack, SR; Shaham, Y; Suska, A; Wang, X; Wolf, ME | 1 |
| Baik, JH; Kim, M; Kim, W; Yoon, BJ | 1 |
| Beveridge, TJ; Calipari, ES; Jones, SR; Porrino, LJ | 1 |
| Adams, MD; Bastle, RM; Brunwasser, SJ; Der-Ghazarian, T; Harder, BG; Neisewander, JL; Peartree, NA; Pentkowski, NS; Yanamandra, K | 1 |
| Fowler, JC; Froeliger, B; Lee, TH; Szabo, ST | 1 |
| Cheng, K; Kalivas, PW; Kupchik, YM; Rice, KC; Roques, BP; Scofield, MD | 1 |
| Correll, CU; Iwata, N; Kishi, T; Matsuda, Y | 1 |
| Chen, JG; Fan, J; Hu, ZL; Jin, Y; Li, YL; Liu, J; Lu, HF; Luo, Y; Wang, F; Wu, PF; Xiao, W; Yang, YJ | 1 |
| Contarino, A; Le Moine, C; Millan, MJ; Morisot, N | 1 |
| Budziszewska, B; Cholewa, J; Detka, J; Filip, M; Frankowska, M; Miszkiel, J; Nowak, E; Przegaliński, E | 1 |
| Beveridge, TJ; Nader, MA; Nader, SH; Porrino, LJ; Smith, HR | 1 |
| deBacker, J; Di Prospero, C; Dumont, ÉC; Gardner Gregory, J; Hawken, ER; Hayton, SJ; Jones, AA; Mechefske, E; Normandeau, CP | 1 |
| Angarita, GA; Bessette, A; Canavan, SV; Forselius, E; Morgan, PT | 1 |
| Daunais, JB; Gopinath, KS; Howell, LL; Maltbie, E; Murnane, KS; Telesford, QK | 1 |
| Calipari, ES; Jones, SR; Siciliano, CA; Zimmer, BA | 1 |
| Grassi-Oliveira, R; Pezzi, JC; Rosa, CS; Tractenberg, SG; Viola, TW; Wearick-Silva, LE | 1 |
| McGinty, JF; Sun, WL; Zelek-Molik, A | 1 |
| Hsu, KS; Huang, CC; Lee, CC; Liang, YC | 1 |
| Filip, M; Frankowska, M; Fumagalli, F; Miszkiel, J; Niedzielska, E; Pomierny, B; Pomierny-Chamiolo, L; Smaga, I | 1 |
| Alexander, DN; Anosike, N; Ballard, SM; Carter, AB; Cox, TA; Freet, CS; Grigson, PS; Imperio, CG; Mahmoud, S; Ruiz-Velasco, V | 1 |
| Al-Hassani, HK; Gregg, RA; Grizzanti, D; Haidery, M; Raffa, RB; Ramnath, A; Rawls, SM; Reitz, AB; Smith, GR; Tallarida, CS; Vouga, A | 1 |
| Eisenstein, SA; McGinty, JF; Sun, WL; Zelek-Molik, A | 1 |
| Benturquia, N; Geoffroy, HA; Noble, F; Puig, S | 1 |
| Dong, Y; Huang, YH; Ishikawa, M; Neumann, PA; Otaka, M; Schlüter, OM | 1 |
| Casas, M; Corominas-Roso, M; Daigre, C; Grau-Lopez, L; Lopez, MV; Ribases, M; Rodríguez-Cintas, L; Roncero, C; Ros-Cucurull, E; Sanchez-Mora, C | 1 |
| Kreek, MJ; Zhou, Y | 1 |
| Craige, CP; Kirby, LG; Lewandowski, S; Unterwald, EM | 1 |
| Davidson, C; Hutchinson, CV; Prados, J | 1 |
| Caffino, L; Fumagalli, F; Giannotti, G; Malpighi, C; Racagni, G | 1 |
| Christian, DT; Loweth, JA; Milovanovic, M; Werner, CT; Wolf, ME | 1 |
| Lecca, S; Mameli, M; Meye, FJ; Tchenio, A; Valentinova, K | 1 |
| Beaumont, M; Doyle, M; Heshmati, M; Khibnik, LA; Nestler, EJ; Russo, SJ; Slesinger, PA | 1 |
| Cahill, CM; Castonguay, A; De Koninck, Y; Evans, CJ; Ghogha, A; Levitt, P; Mehrabani, S; Olmstead, MC; Pradhan, AA; Taylor, AM; Vayssiere, P; Wu, J; Xue, L | 1 |
| Bonci, A; Chang, WC; Chuang, JY; Hung, JJ; Su, TP; Tsai, MS; Tsai, SY; Wang, XF; Xi, ZX | 1 |
| Bomfim, GH; García García, A; Jurkiewicz, A; Jurkiewicz, NH | 1 |
| Ben-Shahar, O; Kippin, TE; Miller, BW; Sacramento, AD; Shin, CB; Silva, HE; Szumlinski, KK; Vieira, PA; Wroten, MG | 1 |
| Guan, X; Guan, Y; Hu, P; Jin, L; Zhu, C; Zhu, W | 1 |
| Silverman, MJ | 1 |
| Caffino, L; Cervo, L; Di Clemente, A; Fumagalli, F; Giannotti, G; Govoni, S; Moro, F; Osera, C; Pascale, A | 1 |
| Anastasio, NC; Cunningham, KA; Fox, RG; Stutz, SJ; Swinford-Jackson, SE | 1 |
| Duan, X; Jiang, X; Li, J; Qu, J; Shen, S; Straubinger, RM; Suarez, M; Thompson, AC; Tu, C | 1 |
| Bires, K; Kim, E; Nayak, S; Rawls, SM; Roberts, A; Tallarida, CS; Wu, M | 1 |
| Dong, Y; Huang, Y; Ma, YY; Marie, H; Nestler, EJ; Schlüter, OM; Wang, X | 1 |
| Chiu, VM; Hill, HH; Sorg, BA; Todd, RP; Zhang, X | 1 |
| Bradberry, CW; Cortes, JA; Ehnerd, C; Gomez, G; Gurnsey, K; Jedema, HP; Nicolazzo, J | 1 |
| Becker, JAJ; Kieffer, BL; Le Merrer, J | 1 |
| Barker, AT; Rebec, GV | 1 |
| Bailey, A; Georgiou, P; Hourani, S; Kitchen, I; Zanos, P | 1 |
| Goldstein, RZ; Moeller, SJ; Parvaz, MA | 1 |
| Catena, A; Perez-Garcia, M; van Son, D; Verdejo-García, A; Wiers, RW | 1 |
| Crouzin, N; Fuentes, S; Hoffmann, HM; McCormick, PJ; Moreno, E; Ortiz, J; Raivio, N; Vignes, M | 1 |
| Duan, F; He, H; Hu, B; Liu, W; Pan, Y; Yang, W; Zhao, D; Zhou, Q | 1 |
| Beroun, A; Dong, Y; Grant, SG; Neumann, PA; Olive, MF; Panopoulou, M; Schlüter, OM; Shukla, A | 1 |
| Álvarez-Dolado, M; Castilla-Ortega, E; Ladrón de Guevara-Miranda, D; Martínez-Losa, M; Millón, C; Missiroli, M; Pavón, FJ; Pérez-Fernández, M; Rodríguez de Fonseca, F; Rosell-Valle, C; Santín, LJ; Serrano, A | 1 |
| Bagdas, D; Carroll, FI; Damaj, MI; Greenwald, M; Jackson, A; Lichtman, AH; Miles, MF; Muldoon, PP | 1 |
| Aguilar, MA; Giménez-Gómez, P; Ledesma, JC; Miñarro, J; Rodríguez-Arias, M | 1 |
| Acker, J; Patel, H; Phillips, AG; Raffa, RB; Rawls, SM; Sacavage, S; Zielinski, M | 1 |
| Bachtell, RK; Chakravarty, S; Green, TA; Kumar, A; Laali, S; Nestler, EJ; Self, DW; Theobald, DE; Winstanley, CA | 1 |
| Reyes, AR; Rudoy, CA; Van Bockstaele, EJ | 1 |
| Hong, JT; Kim, YB; Ma, H; Ma, Y; Nam, SY; Oh, KW | 1 |
| Basta-Kaim, A; Budziszewska, B; Filip, M; Jaworska-Feil, L; Kubera, M; Lason, W; Leskiewicz, M; Machowska, A; Przegalinski, E; Regulska, M; Wydra, K | 1 |
| Alvarez, Jdo N; Carvalho, Rde C; Frussa-Filho, R; Fukushiro, DF; Ribeiro, LT; Ricardo, VP | 1 |
| Dziedzicka-Wasylewska, M; Faron-Górecka, A; Filip, M; Frankowska, M; Kuśmider, M; Wydra, K; Zaniewska, M | 1 |
| Coric, V; Malison, RT; Morgan, PT; Pace-Schott, EF; Sahul, ZH; Stickgold, R | 1 |
| Alves, CJ; De Sousa, L; Magalhães, A; Melo, P; Monteiro, PR; Summavielle, T; Tavares, MA | 1 |
| Bhatia, KS; Ellinwood, EH; Lee, TH; Lyles, J; Nah, SY | 1 |
| Bachtell, RK; Self, DW | 1 |
| Kalivas, PW; Pacchioni, AM; Wiggins, AT | 1 |
| Ghasemzadeh, MB; Mueller, C; Vasudevan, P | 2 |
| France, CP; Galici, R; Gerak, LR | 1 |
| Hsu, KS; Huang, CC; Lee, CC; Liang, YC; Wu, MY | 1 |
| Bouknight, A; Kalivas, PW; Moussawi, K; Shen, HW; Toda, S; Zahm, DS | 1 |
| Self, DW; Simmons, D | 1 |
| Dockstader, C; Grieder, T; Heinmiller, A; Ting-A-Kee, R; van der Kooy, D | 1 |
| Kelamangalath, L; Wagner, JJ | 1 |
| Harvey, BK; Hoffer, BJ; Lu, L; Morales, M; Shaham, Y; Wang, X; Wu, P; Xu, C; Zhao, M | 1 |
| Ford, KA; Hu, XT; Wolf, ME | 1 |
| Guan, X; Li, S; Xu, Y; Zhang, R | 1 |
| Berton, F; Chen, SA; Francesconi, W; Greenwell, TN; Hagihara, K; Koob, GF; Lekic, D; Morales, M; O'Dell, LE; Repunte-Canonigo, V; Rice, KC; Richardson, HN; Sanna, PP; Specio, SE; Thurbon, D; Zorrilla, EP | 1 |
| Baldwin, RM; Bois, F; Cosgrove, KP; Frohlich, EB; Krantzler, E; Krystal, JH; O'Malley, SS; Pittman, B; Seibyl, JP; Staley, JK; Stiklus, S; Tamagnan, GD | 1 |
| Creton, C; Engblom, D; Halbout, B; Lüscher, C; Mameli, M; Parkitna, JR; Spanagel, R | 1 |
| Chen, Q; Lee, TH; Wetsel, WC; Zhang, X; Zhang, Y; Zhu, X | 1 |
| Cepeda, S; Knecht, C; Martínez-Raga, J | 1 |
| Everhart, T; Harris, DS; Jacob, P; Jones, RT; Lin, E; Mendelson, JE | 1 |
| Bigelow, GE; Lin, SN; Moody, DE; Stoops, WW; Walsh, SL | 1 |
| McDevitt, RA; Neumaier, JF; Parsons, LH; Polis, IY | 1 |
| Neisewander, JL; Pentkowski, NS; Sanabria, F; Thiel, KJ | 1 |
| Ambrose-Lanci, LM; Sterling, RC; Van Bockstaele, EJ | 1 |
| Ferrario, CR; Li, X; Reimers, JM; Uejima, JL; Wang, X; Wolf, ME | 1 |
| Cui, FJ; Hwang, JY; Kang, UG; Park, HJ | 1 |
| Rosario, A; Santucci, AC | 1 |
| Erb, S | 1 |
| Balasubramaniam, A; Jayanthi, LD; Ramamoorthy, S; Samuvel, DJ; See, RE | 1 |
| Malison, RT; Morgan, PT; Pace-Schott, E; Pittman, B; Stickgold, R | 1 |
| Carroll, KM; Ding, YS; Ide, JS; Li, CS; Luo, X; Malison, RT; Rounsaville, BJ; Sinha, R; Zhang, S | 1 |
| Brucklacher, RM; Freeman, WM; Lull, ME; Morgan, D; Patel, KM; Roberts, DC; Vrana, KE | 1 |
| Dackis, C; O'Brien, CP | 1 |
| Buccafusco, JJ; Hall, BJ; Pearson, LS | 1 |
| Caldarone, B; Fedolak, A; Ghavami, A; Hanania, T; Olivier, B; Paterson, NE | 1 |
| Centeno, M; Fu, Y; Gallagher, JP; Genzer, K; Krishnan, B; Liu, J; Pollandt, S; Shinnick-Gallagher, P | 1 |
| Kalivas, PW; Shen, H; Toda, S | 1 |
| Bijlsma, EY; Groenink, L; Olivier, B | 1 |
| Conrad, KL; Ford, K; Marinelli, M; Wolf, ME | 1 |
| Ho, A; Kreek, MJ; Piras, AP; Schlussman, SD; Zhou, Y | 1 |
| Alenina, N; Bader, M; Filip, M; Przegaliński, E | 1 |
| Cepeda-Benito, A; Fernández-Santaella, MC; Martínez, JA; Muñoz, MA; Vila, J | 1 |
| Patil, T; Raffa, RB; Rawls, SM; Yuvasheva, E | 1 |
| Epstein, DH; Preston, KL | 1 |
| Akkentli, F; Alibhai, IN; Edwards, S; Graham, DL; Larson, EB; Nestler, EJ; Self, DW; Simmons, DL | 1 |
| Kroener, S; Lavin, A | 1 |
| Kreek, MJ; Maiya, R; Norris, EH; Strickland, S; Zhou, Y | 1 |
| Henry, PK; Howell, LL; Murnane, KS; Votaw, JR | 1 |
| Cooper, ZD; Shi, YG; Woods, JH | 1 |
| Abraham, L; Aharoni, S; Ben-Tzion, M; Croitoru, O; Flaumenhaft, Y; Gispan, I; Kinor, N; Roth-Deri, I; Shaldubina, A; Sudai, E; Yadid, G | 1 |
| Chen, CL; Guan, X; Guan, Y; Li, S; Wang, L | 1 |
| Greenwald, MK; Lundahl, LH; Steinmiller, CL | 1 |
| Hu, XT; Nasif, FJ; Perez, MF; Ramirez, OA | 1 |
| Ding, ZB; Li, SX; Lu, L; Luo, YX; Shi, HS; Wei, YM; Xue, YX; Yu, CX | 1 |
| Forselius, E; Malison, RT; Matuskey, D; Morgan, PT; Pittman, B | 1 |
| Corcoran, S; Cuthbert, B; Duncan, E; Hollis, J; Norrholm, SD; Sternberg, M | 1 |
| Gabriele, A; Pacchioni, AM; See, RE | 2 |
| Kreek, MJ; Lane, DA; Pickel, VM; Reed, B | 1 |
| Dong, Y; Lee, BR | 1 |
| Ferrario, CR; Ford, KA; Galiñanes, GL; Heng, LJ; Loweth, JA; Milovanovic, M; Tseng, KY; Wolf, ME | 1 |
| Alvarez, VA; Bock, R; Christensen, CH; Dobi, A; Seabold, GK | 1 |
| Do, PH; Kalivas, PW; Moussawi, K; Reichel, CM; See, RE | 1 |
| Bachtell, RK; Edwards, S; Guzman, D; Self, DW; Whisler, KN | 1 |
| Han, JY; Hong, JT; Kim, YB; Nam, SY; Oh, KW; Song, S; Yang, SL | 1 |
| Chan, JY; Chan, SH; Chang, AY; Hsu, KS; Huang, CC; Wu, MY; Yeh, CM | 1 |
| He, YY; Li, FQ; Li, YQ; Lu, L; Sacktor, TC; Shaham, Y; Xu, CM; Xue, LF; Xue, YX | 1 |
| Marinelli, M; McCutcheon, JE; Tseng, KY; Wang, X; Wolf, ME | 1 |
| Galuska, CM; Wade-Galuska, T; Winger, G | 1 |
| Markou, A; Stoker, AK | 1 |
| Kreek, MJ; Litvin, Y; Pfaff, DW; Piras, AP; Zhou, Y | 1 |
| Carlezon, WA; Chartoff, E; Pliakas, A; Potter, D; Rachlin, A; Sawyer, A | 1 |
| Centeno, M; Gallagher, JP; Genzer, K; Krishnan, B; Liu, J; Orozco-Cabal, L; Pollandt, S; Schmidt, K; Shinnick-Gallagher, P; Sun, A; Xia, Y | 1 |
| Boutrel, B; Koob, GF; Specio, S; Wee, S; Weiss, F; Zhao, Y; Zorrilla, EP | 1 |
| Boonstra, R; Erb, S; Kupferschmidt, DA; Newman, AE | 1 |
| Akil, H; Flagel, SB; García-Fuster, MJ; Mahmood, ST; Mayo, LM; Thompson, RC; Watson, SJ | 1 |
| Crawford, CA; Mitroi, D; Neisewander, JL; Painter, MR; Pentkowski, NS; Thiel, KJ | 1 |
| Gallagher, JP; Genzer, KM; Krishnan, B; Liu, J; Pollandt, SW; Shinnick-Gallagher, P | 1 |
| Cha, JH; Darnell, SB; Pierce, RC; Sadri-Vakili, G; Sangrey, GR; Schassburger, RL; Schmidt, HD | 1 |
| Arzaga, RR; Bass, CE; Buzin, N; Graham, DL; Green, TA; Larson, EB; Nestler, EJ; Neve, RL; Self, DW; Terwilliger, EF; Webb, J | 1 |
| Markou, A; Olivier, B; Stoker, AK | 1 |
| Casso, S; DeMuth, G; Fox, BS; Goeders, NE; Hefti, F; Kablinger, AS; Lindner, MA; McCarthy, BG; McNair, LA | 1 |
| da Silva, FC; de Oliveira Citó, Mdo C; de Sousa, FC; de Vasconcelos, SM; Fonteles, MM; Macêdo, DS; Moura, BA; Silva, MI; Woods, DJ | 1 |
| Dackis, CA; Kampman, KM; Lynch, KG; O'Brien, CP; Pettinati, HM; Plebani, JG; Sparkman, T | 1 |
| Jansen, HT; Sergeeva, A; Sorg, BA; Stark, G | 1 |
| Butelman, ER; Ho, A; Kreek, MJ; Schlussman, SD; Zhang, Y | 1 |
| Baldwin, CK; Buffalari, DM; See, RE | 1 |
| Adams, MD; Cheung, TH; Neisewander, JL; Neumaier, JF; Pentkowski, NS; Toy, WA | 1 |
| Canales, JJ; Ferragud, A; García-Sevilla, JA; Ramos-Miguel, A; Velázquez-Sánchez, C | 1 |
| Akil, H; Flagel, SB; García-Fuster, MJ; Mahmood, ST; Watson, SJ | 1 |
| Ferrario, CR; Goussakov, I; Stutzmann, GE; Wolf, ME | 1 |
| Koob, GF; Misra, KK; Schlosburg, JE; Vendruscolo, LF; Wee, S | 1 |
| Bérod, A; El Hage, C; Etievant, A; Morel, AL; Rappeneau, V; Scarna, H; Zimmer, L | 1 |
| Baker, DA; Kau, KS; Kong, L; Lutgen, V; Madayag, A; Mantsch, JR | 1 |
| Karlsson, RM; Kircher, DM; O'Donnell, P; Shaham, Y | 1 |
| Czaja, K; Dong, Y; Gallaher, ZR; Huang, X; Huang, YH; Ishikawa, M; Krueger, JM; Krüger, JM; Schlüter, OM; Winters, BD | 1 |
| Corley, G; Kovalevich, J; Langford, D; Rawls, SM; Yen, W | 1 |
| Castner, SA; Williams, GV | 1 |
| Duff, MO; Eipper, BA; Eipper-Mains, JE; Graveley, BR; Horowitz, MJ; Kiraly, DD; Mains, RE; McManus, CJ | 1 |
| Sierra, JC; Vallejo-Medina, P | 1 |
| Butelman, ER; Ho, A; Kreek, MJ; Rabkin, J; Schlussman, SD; Zhang, Y | 1 |
| Grigson, PS; Nyland, JE | 1 |
| Chavkin, C; Chavkin, NW; Gustin, RM; Hagan, CE; Lemos, JC; Messinger, DI; Neumaier, JF; Schattauer, SS; Schindler, AG; Shankar, H; Smith, JS | 1 |
| Chen, X; Damaj, MI; Jackson, KJ; Sanjakdar, SS | 1 |
| Cuadra, GR; Maldonado, NM; Orsingher, OA; Valdomero, A; Velazquez, EE | 1 |
| Ferraro, L; Filip, M; Fuxe, K; Golembiowska, K; Kamińska, K; Wydra, K; Zaniewska, M | 1 |
| Bahi, A; DeJoseph, MR; Dreyer, JL; Ferrario, CR; Ford, KA; Li, X; Loweth, JA; Meredith, GE; Urban, JH; Wolf, ME | 1 |
| Castro, G; Hilburn, C; King, GR; Konen, J; Pinto, G; Tran, S | 1 |
| Berman, J; Gonzalez, B; Roy, A; Roy, M | 1 |
| Insua, A; Kaempf, G; Kampman, KM; Lipkin, C; O'Brien, CP; Pettinati, H; Sparkman, T; Turk, E; Volpicelli, J | 1 |
| Finn, DA; Grubb, MC; Mark, GP; Welch, JR | 1 |
| Davidson, C; Ellinwood, EH; Lee, TH; Xiong, Z | 1 |
| Mihalakopoulos, A; Stellar, JR; Todtenkopf, MS | 1 |
| Grimm, JW; Hope, BT; Shaham, Y | 1 |
| Brebner, K; Lynch, WJ; Morgan, D; Roberts, DC | 1 |
| Di Ciano, P; Everitt, BJ | 1 |
| Davidson, C; Ellinwood, EH; Lazarus, C; Lee, TH; Xiong, X | 1 |
| Jackman, SL; Olmstead, MC; Paine, TA | 1 |
| Janowsky, A; Loftis, JM | 2 |
| Bencetti, ML; Caricati, AM; Grassi, MC; Nencini, P | 1 |
| Barros, HM; Loebens, M | 1 |
| Carroll, FI; Kimmel, HL; Kuhar, MJ | 1 |
| Grimm, JW; Hayashi, T; Hope, BT; Lu, L; Shaham, Y; Su, TP | 1 |
| Ho, A; Kreek, MJ; Schlussman, SD; Spangler, R; Zhou, Y | 1 |
| Deroche-Gamonet, V; Le Moal, M; Martinez, A; Piazza, PV | 1 |
| Brown, SB; Dudish-Poulsen, S; Hatsukami, DK; Sofuoglu, M | 1 |
| Avila, AH; Bayer, BM; Morgan, CA | 1 |
| Bowers, MS; Kalivas, PW | 1 |
| Hotsenpiller, G; Wolf, ME | 1 |
| Berman, J; Bissette, G; Gonzalez, B; Roy, A; Williams, R | 1 |
| Covington, HE; Miczek, KA | 1 |
| Kalivas, PW; Lake, R; Ramamoorthy, S; Samuvel, DJ; Shen, H; Xi, ZX | 1 |
| Hikida, T; Kitabatake, Y; Nakanishi, S; Pastan, I | 1 |
| Baker, LK; Cooper, DC; Marinelli, M; White, FJ | 1 |
| Kalechstein, AD; Ling, W; Newton, TF; Tervo, KE | 1 |
| Maj, M; Przewłocka, B; Smiałowska, M; Turchan, J | 1 |
| Baker, DA; Kalivas, PW; Lake, RW; McFarland, K; Shen, H; Tang, XC; Toda, S | 1 |
| Ho, A; Kreek, MJ; Spangler, R; Zhou, Y | 1 |
| Grimm, JW; Hope, BT; Lu, L; Shaham, Y | 1 |
| Achat-Mendes, C; Anderson, KL; Itzhak, Y | 1 |
| Blendy, JA; Funk, CD; Godfrey, M; Sun, D; Walters, CL; Wang, BC | 1 |
| Dürsteler-MacFarland, KM; Stohler, R | 1 |
| Castro, VJ | 1 |
| Goletiani, NV; Jaszyna-Gasior, M; Mello, NK; Mendelson, JH; Mutschler, NH; Sholar, MB; Siegel, AJ | 1 |
| Koeltzow, TE; White, FJ | 1 |
| Camí, J; Farré, M | 1 |
| Basile, A; Bolwig, TG; Fedorova, I; Fink-Jensen, A; Knitowski, KM; McKinzie, DL; Rasmussen, T; Thomsen, M; Wess, J; Woldbye, DP; Wörtwein, G; Yamada, M | 1 |
| GLATT, MM | 2 |
| Battaglia, G; Carrasco, GA; D'Souza, DN; Damjanoska, KJ; Garcia, F; Muma, NA; Van de Kar, LD; Zhang, Y | 2 |
| France, CP; McMahon, LR; Sell, SL | 1 |
| Li, N; Sorg, BA; Wu, WR | 1 |
| Bizet, C; Derumeaux, G; Lallemand, F; Monteil, C; Moritz, F; Mulder, P; Renet, S; Richard, V; Thuillez, C | 1 |
| De Vries, TJ; Homberg, JR; Raasø, HS; Schoffelmeer, AN; Wardeh, G | 1 |
| France, CP; McMahon, LR | 1 |
| Czepiel, K; Dlaboga, D; Filip, M; Nowak, E; Przegaliński, E | 1 |
| Broderick, PA; Hope, O; Okonji, C; Rahni, DN; Zhou, Y | 1 |
| Kozell, LB; Meshul, CK | 1 |
| Markou, A; Paterson, NE | 1 |
| Alonzo, NC; Avila, AH; Bayer, BM | 1 |
| Crozatier, C; Giros, B; Guerriero, RM; Kosofsky, BE; Mathieu, F; Nosten-Bertrand, M | 1 |
| Bossert, JM; Dempsey, J; Liu, SY; Lu, L; Shaham, Y | 1 |
| Dempsey, J; Lu, L | 1 |
| Dempsey, J; Grimm, JW; Lu, L; Shaham, Y | 1 |
| Ashby, CR; Campos, AC; Gardner, EL; Gilbert, J; Hagan, JJ; Heidbreder, CA; Kline, N; Xi, ZX | 1 |
| Bowers, MS; Gregory, ML; Kalivas, PW; Lake, RW; Lanier, SM; Lapish, CC; McFarland, K; Peterson, YK | 1 |
| Beauvals, J; Browndyke, JN; Cohen, RA; Gottschalk, PC; Kosten, TR; Tucker, KA; Woods, SP | 1 |
| Baumann, MH; Milchanowski, AB; Rothman, RB | 1 |
| Coffey, GP; Fuchs, RA; Joyce, JN; Neisewander, JL; Tran-Nguyen, LT; Weber, SM | 1 |
| Freeman, WM; Hemby, SE; Liang, B; Tang, W; Wesley, M | 1 |
| Cheng, HY; Laviolette, SR; Penninger, JM; van der Kooy, D | 1 |
| Gosnell, BA; Swant, J; Thompson, AM; Wagner, JJ | 1 |
| Hillburn, C; King, GR; Konen, J; Pinto, G | 1 |
| Grasing, K; He, S | 1 |
| Raffa, RB; Stagliano, GW; Umeda, S | 1 |
| Morgan, D; Roberts, DC; Smith, MA | 1 |
| Barros, HM; Lucion, AB; Marquardt, AR; Ortiz-Lemos, L | 1 |
| Hinken, C; Li, SH; Majewska, MD; Plotkin, D; Setoda, D; Van Gorp, W; Wilkins, JN | 1 |
| di Giannantonio, M; Farina, B | 1 |
| Bibb, JA; Daubner, SC; Fitzpatrick, PF; Haycock, JW; Hope, BT; Kansy, JW; Lloyd, MD; Lu, L; Nguyen, C; Nishi, A; Sotogaku, N | 1 |
| Davidson, C; Ellinwood, EH; Lazarus, C; Lee, TH | 1 |
| Besson, J; Borgeat, F; Hättenschwiler, J; Khazaal, Y; Zullino, DF | 1 |
| Chrostek Maj, J; Kamenczak, A; Kroch, S; Polewka, A; Szerszeń-Motyka, J | 1 |
| Leppävuori, A; Rovasalo, A | 1 |
| Bossert, JM; Dempsey, J; Hope, BT; Liu, SY; Lu, L; Shaham, Y | 1 |
| Davidson, C; Ellinwood, EH; Lee, TH | 2 |
| Jones, SR; Lack, CM; Mateo, Y; Morgan, D; Roberts, DC | 1 |
| France, CP; Koek, W; McMahon, LR; Sell, SL | 1 |
| Murphy, NP; Sakoori, K | 1 |
| Antkiewicz-Michaluk, L; Filip, M; Michaluk, J; Papla, I; Patsenka, A; Przegaliński, E; Romańska, I; Vetulani, J | 1 |
| Bailey, A; Gianotti, R; Ho, A; Kreek, MJ | 1 |
| Bailey, A; Bendor, J; Ho, A; Kreek, MJ; Schlussman, SD; Yuferov, V; Zhou, Y | 1 |
| Dempsey, J; Hope, BT; Lu, L; Shaham, Y | 1 |
| Beversdorf, DQ; Kelley, BJ; Pepper, TH; Yeager, KR | 1 |
| Bendor, JT; Ho, A; Kreek, MJ; Schlussman, SD; Yuferov, V; Zhou, Y | 1 |
| Hamby, SM; McCracken, CB; Morgan, D; Patel, KM; Roberts, DC; Vrana, KE | 1 |
| Ben-Shahar, O; Ettenberg, A; Jacob, B; Moscarello, JM; Roarty, MP | 1 |
| Hemby, SE; Horman, B; Tang, W | 1 |
| Kline, A; Losonczy, M; Rodrigues, S; Smelson, DA; Sussner, BD; Ziedonis, D | 1 |
| Läck, C; Morgan, D; Roberts, DC; Ward, SJ | 1 |
| Bolshakov, VY; Carlezon, WA; Chartoff, EH; Gerety, LP; Goussakov, I; Meloni, EG; Tsvetkov, E | 1 |
| Dziedzicka-Wasylewska, M; Faron-Górecka, A; Filip, M; Frankowska, M; Gołda, A; Kuśmider, M | 1 |
| Cagle, S; Kalivas, PW; Peters, J; Shen, HW; Toda, S | 1 |
| Buse, C; Fyall, A; Grimm, JW; Manaois, M; Osincup, D; Wells, B | 1 |
| Beard, L; Brown, ES; Dhanani, N; Orsulak, P; Perantie, DC; Rush, AJ | 1 |
| Edwards, S; Fuller, DC; Orsulak, PJ; Self, DW; Whisler, KN | 1 |
| Branham, RK; Fuchs, RA; See, RE | 1 |
| Brenhouse, HC; Montalto, S; Stellar, JR | 1 |
| Rebec, GV; Sun, W | 1 |
| Aharonovich, E; Bisaga, A; Brooks, DJ; Levin, FR; Nunes, EV; Raby, W; Rubin, E | 1 |
| da Silveira, DX; Fernandes, M; Jorge, MR; Silveira, ED | 1 |
| Liu, QS; Poo, MM; Pu, L | 1 |
| Atzram, M; Dackis, C; Gariti, P; Kampman, KM; Lynch, KG; O'Brien, CP; Pettinati, H; Sparkman, T; Tirado, C | 1 |
| Cunningham, KA; Geng, T; Kurosky, A; Luxon, BA; Seitz, PK; Soman, KV; Thomas, ML; Xu, B | 1 |
| Baron, DA; Raffa, RB; Rawls, SM; Rodriguez, T | 1 |
| Ahtee, L; Mijatovic, J; Piepponen, TP; Tuominen, RK; Vihavainen, T | 1 |
| Antkiewicz-Michaluk, L; Filip, M; Michaluk, J; Przegaliński, E; Romańska, I; Vetulani, J | 1 |
| Raffa, RB; Stagliano, GW; Tallarida, RJ | 2 |
| Adelson, M; Naumovsky, Y; Peles, E; Schreiber, S | 1 |
| Battaglia, G; Carrasco, GA; Garcia, F; Landry, M; Muma, NA; Sullivan, NR; Van de Kar, LD | 1 |
| Manzardo, AM; O'Dell, LE; Parsons, LH; Polis, I; Stouffer, DG | 1 |
| Fu, Y; Gallagher, JP; Genzer, K; Krishnan, B; Liu, J; Orozco-Cabal, L; Pollandt, S; Shinnick-Gallagher, P | 1 |
| Epstein, DH; Heinz, AJ; Heishman, SJ; Preston, KL; Schroeder, JR; Singleton, EG | 1 |
| Kalivas, PW; Lavin, A; Nogueira, L | 1 |
| Gonsai, K; Gonzalez, G; Kosten, T; Poling, J; Sofuoglu, M | 1 |
| Ben-Shahar, O; Brake, W; Cook, M; Ettenberg, A; Heston, R; Joyce, M; Keeley, P; Nyffeler, M | 1 |
| Caldarone, BJ; Kiraly, DD; Lynch, WJ; Picciotto, MR; Taylor, JR | 1 |
| Biswas, S; Harlan, RE; Neisewander, JL; Zavala, AR | 1 |
| Axelrod, SR; Fox, HC; Paliwal, P; Sinha, R; Sleeper, J | 1 |
| Cullinan, WE; Katz, ES; Khan, T; Mantsch, JR; Sajan, T; Tang, LC; Taves, S; Ziegler, DR | 1 |
| Boutros, N; Stanley, J; Sundaresan, K; Ziemann, U | 1 |
| Agnati, L; Filip, M; Franco, R; Fuxe, K; Lluís, C; Marcellino, D; Navarro, G; Roberts, DC | 1 |
| Bérod, A; Espinosa, JM; Felszeghy, K; Pélaprat, D; Rostène, W; Scarna, H | 1 |
| Alvarez, Jdo N; Chinen, CC; de Castro, JP; Frussa-Filho, R; Fukushiro, DF; Tatsu, JA | 1 |
| Chen, SQ; Cui, YY; Le Foll, B; Lu, L; Shi, J; Zhai, HF | 1 |
| Aujla, H; González-Cuevas, G; López-Moreno, JA; Martin-Fardon, R; Navarro, M; Weiss, F | 1 |
| Groth-Marnat, G; Howchar, H; Marsh, A | 1 |
| Hu, XT | 1 |
| Calu, DJ; Franz, TM; Schoenbaum, G; Shaham, Y; Singh, T; Stalnaker, TA | 1 |
| Aston-Jones, G; Harris, GC; Hummel, M; Mague, SD; Wimmer, M | 1 |
| Elliott, JC; Feltenstein, MW; See, RE | 1 |
| Hearing, MC; McGinty, JF; Schwendt, M; See, RE | 1 |
| Berglind, WJ; Fuchs, RA; Ghee, SM; McGinty, JF; Miller, SW; See, RE; Whitfield, TW | 1 |
| Eaton, CA; Martin, RA; Monti, PM; Rohsenow, DJ | 1 |
| Bonci, A; Bowers, MS; Chen, BT; Hopf, FW; Martin, M; Mohamedi, MM | 1 |
| Jones, SR; Lack, CM; Roberts, DC | 1 |
| Cabral, H; López-Patiño, MA; Yu, L; Zhdanova, IV | 1 |
| Fox, HC; Hong, KA; Morgan, PT; Paliwal, P; Sinha, R | 1 |
| Boudreau, AC; Milovanovic, M; Reimers, JM; Wolf, ME | 1 |
| Beveridge, TJ; Nader, MA; Porrino, LJ; Smith, HR | 1 |
| Roberts, DC; Smith, MA; Ward, SJ | 1 |
| De Biasi, M; Gangitano, D; Main, A; Salas, R | 1 |
| Ary, AW; Szumlinski, KK | 1 |
| Nwaneshiudu, CA; Perrine, SA; Schroeder, JA; Sheikh, IS; Unterwald, EM | 1 |
| Ding, Z; Phillips, AG; Powell, JA; Raffa, RB; Rawls, SM; Ross, G; Stagliano, GW | 1 |
| Jayanthi, LD; Kaliyaperumal, K; Manohar, S; Ramamoorthy, S; Samuvel, DJ; See, RE | 1 |
| Boyd, SJ; Copersino, ML; Epstein, D; Gorelick, DA; Levin, KH | 1 |
| Aguilar, VR; Kerstetter, KA; Kippin, TE; Parrish, AB | 1 |
| Pagán, OR; Rowlands, AL | 1 |
| Berger, M; Hornyak, M; Riemann, D; Schierenbeck, T | 1 |
| Choi, KH; Eisch, AJ; Noonan, MA; Self, DW | 1 |
| Capasso, A; Cavallo, F; Ding, Z; Raffa, RB; Rawls, SM | 1 |
| Jones, JL | 1 |
| Kim, JH; Kim, S | 1 |
| Caba, J; Hernandez, L; Santucci, AC | 1 |
| Ambrose-Lanci, LM; Peiris, NB; Unterwald, EM; Van Bockstaele, EJ | 1 |
| Choi, JC; Cui, CL; Han, JS; Ho, A; Kreek, MJ; Schlussman, SD; Zhou, Y | 1 |
| Hearing, MC; McGinty, JF; See, RE | 1 |
| Kampman, KM | 1 |
| Bogenschutz, MP; DeMarzo, LJ; Roll, J | 1 |
| López Patiño, MA; Yamamoto, BK; Yu, L; Zhdanova, IV | 1 |
| Madeira, E; Santucci, AC | 1 |
| Banfi, S; Maffii, G | 1 |
| Smith, DE | 1 |
| Johnson, DA | 1 |
| Dackis, CA; Gold, MS | 6 |
| Tarver, AL; Tennant, FS | 1 |
| Goldsmith, D; Hunt, DE; Lipton, DS; Strug, D | 1 |
| Resnick, EB; Resnick, RB | 1 |
| Baxter, LR | 1 |
| Balster, RL; Harris, LS; Wessinger, WD; Woolverton, WL | 1 |
| Balster, RL; Wessinger, WD; Woolverton, WL | 1 |
| Spratto, GR; Wiechman, BE | 1 |
| Valdman, AV; Zvartau, EE | 1 |
| Yamamoto, K; Yoshimura, K | 1 |
| Spratto, GR; Wiechman, BE; Wood, TE | 1 |
| Kalivas, PW; Pierce, RC | 1 |
| Griffin, ML; Hufford, C; Weiss, RD | 1 |
| Covi, L; Haertzen, CA; Hess, JM; Kreiter, NA | 1 |
| Baumann, MH; Becketts, KM; Rothman, RB | 1 |
| Co, C; Dworkin, SI; Smith, JE | 1 |
| Koob, GF; Parsons, LH; Weiss, F | 2 |
| Bigelow, GE; Garner, JE; Ginn, DH; Haberny, KA; Setoda, D; Walsh, SL; Wilkins, JN | 1 |
| Grimm, JW; Lynch, AM; Meil, WM; Roll, JM; See, RE | 1 |
| Alterman, AI; Cacciola, JS; Kaplan, MR; McKay, JR; Rutherford, MJ | 1 |
| Michiels, K; Palmer, JA; Palmer, LK; Thigpen, B | 1 |
| McCann, MJ; Obert, JL; Rawson, RA; Shoptaw, S | 1 |
| Foote, J; Handelsman, L; Lovejoy, M; Magura, S; Rosenblum, A; Stimmel, B | 1 |
| Galloway, GP; Knapp, T; Newmeyer, J; Smith, D; Stalcup, SA | 1 |
| Grace, AA | 1 |
| DePetrillo, PB; Rice, JM | 1 |
| Eiler, K; Lowery, R; Salstrom, D; Schaefer, MR | 1 |
| Thorp, JM | 1 |
| Bíró, E; Gardi, J; Julesz, J; Sarnyai, Z; Telegdy, G; Vecsernyés, M | 1 |
| Beatty, WW; Katzung, VM; Moreland, VJ; Nixon, SJ | 1 |
| Gold, MS; Miller, NS | 1 |
| Sevarino, KA; Walker, JR | 1 |
| Kosten, TR; Stine, SM | 1 |
| Kosten, TR; Lago, JA | 1 |
| Babb, Sm; Cohen, BM; Ennulat, DJ | 1 |
| Blair, RD; Carlen, PL; Noldy, NE; Politzer, N; Santos, CV | 1 |
| Aston-Jones, G; Harris, GC | 1 |
| Ellinwood, EH; King, GR; Kuhn, C | 1 |
| Herz, A | 2 |
| Ellinwood, EH; Joyner, C; King, GR | 2 |
| Kuhar, MJ; Pilotte, NS; Sharpe, LG | 1 |
| Hooks, SM; Meiergerd, SM; Schenk, JO | 1 |
| Drieze, JM; Kelly, ML; Mello, NK; Mendelson, JH; Sholar, JW; Teoh, SK | 1 |
| Bauer, LO; Kranzler, HR | 2 |
| Bryant, KJ; Carroll, KM; Rounsaville, BJ | 1 |
| Kaminer, Y | 1 |
| Fung, YK; Richard, LA | 1 |
| Koob, GF; Pulvirenti, L | 1 |
| Gillin, JC; Golshan, S; Koob, G; Pulvirenti, L; Withers, N | 1 |
| Black, JE; Heninger, GR; Kosten, TR; Malison, RT; McDougle, CJ; Price, LH; Zimmermann, RC | 1 |
| Davis, JM; Javaid, JI; Notorangelo, MP; Pandey, GN; Pandey, SC; Reddy, PL | 1 |
| Alim, TN; Deutsch, SI; McCarthy, MF; Rosse, RB | 1 |
| Mansbach, RS; Markou, A; Patrick, GA | 1 |
| Ator, NA; Griffiths, RR; Sannerud, CA | 1 |
| Gray, JD | 1 |
| Lucki, I; McGonigle, P; Neisewander, JL | 2 |
| Haertzen, CA; Henningfield, JE; Singleton, E; Tiffany, ST | 1 |
| Carroll, ME; Dixon, LM; Kish, SJ; Lac, ST; Niznik, HB; Nobrega, JN; Pristupa, ZB; Shannak, K; Wilson, JM | 1 |
| Caron, MG; Ellinwood, EH; Joyner, CM; King, GR; Lee, TH; Silvia, C; Xue, Z | 1 |
| Aronson, MJ; Handelsman, L; Hershkowitz, A; Kanof, PD; Ness, R | 1 |
| Egan, MF; Karoum, F; Wyatt, RJ | 1 |
| Ellinwood, EH; Joyner, CM; King, GR | 2 |
| Breen, KJ; Swartz, CM | 1 |
| Das, G; Laddu, A | 1 |
| Aceto, MD; Bowman, ER | 1 |
| Fitch, TE; Roberts, DC | 1 |
| Carroll, ME | 1 |
| Compton, WM; Cottler, LB; Mager, D; Shillington, AM; Spitznagel, EL | 1 |
| Hudzik, TJ; McMillan, DE; Wessinger, WD | 1 |
| Chen, NH; Reith, ME | 1 |
| Kosten, TR; McDougle, CJ; Pearsall, HR; Price, LH; Rosen, MI; Woods, SW | 1 |
| Baumann, MH; Brockington, AM; Rothman, RB | 1 |
| Johnson, DN; Vocci, FJ | 1 |
| Das, G; Prakash, A | 1 |
| Manschreck, TC | 1 |
| Earnest, MP | 1 |
| Cardoso, F; Jankovic, J | 1 |
| Gold, MS; Miller, NS; Summers, GL | 1 |
| Blevins, O; Dubois, J; Elder, IR; Flowers, Q; Sebastian, PS; Voris, J | 1 |
| Bauer, LO; Roberts, LA | 1 |
| Berry, J; Boone, K; Herzberg, DS; Hinkin, C; Steinman, L; van Gorp, WG; Wilkins, JN | 1 |
| Angrist, B; Sanfilipo, M; Wolfsohn, R | 1 |
| Satel, SL; Swann, AC | 1 |
| Ellinwood, EH; Joyner, C; King, GR; Lee, TH | 1 |
| Das, G | 1 |
| Carlson, GA; Crosby, RD; Halikas, JA; Nugent, SM | 1 |
| Hammer, RP; Koob, GF; Markou, A; Pires, WS | 1 |
| Alim, TN; Deutsch, SI; Hess, AL; Miller, MW; Rosse, RB | 1 |
| Cass, WA; Curella, P; Gerhardt, GA; Gillespie, K; Mayfield, RD; Zahniser, NR | 1 |
| Cass, WA; Zahniser, NR | 1 |
| Bauer, LO | 1 |
| Handelsman, L; Limpitlaw, L; Paris, P; Schmeidler, J; Stimmel, B; Williams, D | 1 |
| Klein, DF; Koenig, T; McGrath, PJ; Nunes, EV; Ocepek-Welikson, K; Quitkin, FM; Stewart, JW; Wager, S | 1 |
| Bauer, LO; Hersh, D; Kranzler, HR | 1 |
| Charney, DS; Kosten, TR; Krystal, JH; Stine, SM | 1 |
| Cornwell, A; Dewart, D; Ercegovac, DV; Jackson, P; Roemer, RA | 1 |
| Borison, RL; Cassano, GB; Diamond, BI; Marazziti, D; Pathiraja, A | 1 |
| Koob, GF | 3 |
| Christensen, JD; Cohen, BM; Holman, BL; Kaufman, MJ; Levin, JM; Mendelson, JH; Renshaw, PF | 1 |
| Doepel, FM; Ervin, FR; Mash, DC; Palmour, RM; Staley, JK; Young, SN | 1 |
| Roy, A; Roy, M; Smelson, DA | 3 |
| Pert, A | 1 |
| Wise, RA | 1 |
| Gillin, JC; Golshan, S; Irwin, M; Thompson, PM | 1 |
| Kuhar, MJ; Pilotte, NS | 1 |
| Butts, JD; Clark, TB; Little, KY; Patel, UN | 1 |
| Baumann, MH; Rothman, RB | 2 |
| Pilotte, NS; Sharpe, LG | 1 |
| Gawin, FH; Khalsa-Denison, ME | 1 |
| Fischman, MW; Foltin, RW | 3 |
| Bolla, KI; Cadet, JL | 1 |
| Kuhar, MJ; Pilotte, NS; Rountree, SD; Sharpe, LG | 1 |
| Barros, HM; Miczek, KA | 1 |
| Bigelow, GE; Liebson, IA; Stitzer, ML; Strain, EC | 1 |
| Avants, SK; Kosten, TR; Margolin, A | 1 |
| Kouri, EM; Lukas, SE; Mendelson, JH | 1 |
| Dannals, RF; Frost, JJ; Gorelick, DA; Ravert, HT; Stauffer, R; Zubieta, JK | 1 |
| Cooke, ES; Hammer, RP | 1 |
| Barros, HM; Belej, T; Manji, D; Nobrega, JN; Sioutis, S | 1 |
| Galloway, MP; Norton, CS | 1 |
| Roy, A; Roy, M; Smelson, D | 1 |
| Ellinwood, EH; Gao, WY; Lee, TH | 1 |
| Roy, A; Roy, M; Smelson, D; Weinberger, L; Williams, J | 1 |
| Ambrosio, E; Pilotte, NS; Sharpe, LG | 1 |
| Allen, TJ; Cherek, DR; Dougherty, DM; Moeller, FG; Rustin, T; Shah, N; Swann, AC | 1 |
| Ho, A; Kreek, MJ; Maggos, CE; Schlussman, SD; Spangler, R; Zhou, Y | 1 |
| Ellinwood, EH; King, GR; Xiong, Z | 2 |
| Barbato, M; Cooper, T; Elangovan, N; Winsberg, B | 1 |
| Connerney, I; Fischman, MW; Foltin, RW; Levin, FR | 1 |
| Better, WE; Cadet, JL; Gorelick, DA; Guo, X; Herning, RI; Lange, WR; Weinhold, LL | 1 |
| King, GR; Matell, MS | 1 |
| Bigelow, GE; Eissenberg, T; Johnson, RE; Liebson, IA; Stitzer, ML; Strain, EC; Walsh, SL | 1 |
| Carlen, PL; Noldy, NE | 1 |
| Bauer, LO; Easton, CJ | 1 |
| Johns, JM; Li, L; Noonan, LR; Pedersen, CA; Zimmerman, LI | 1 |
| Bauer, L; Costa, L | 1 |
| Baird, TJ; Briscoe, RJ; Carl, KL; Gauvin, DV; Holloway, FA; Vallett, M | 1 |
| Dudish-Poulsen, SA; Hatsukami, DK | 1 |
| Brown, S; Desai, P; Roy, A; Roy, M; Smelson, D | 1 |
| Darmani, NA | 2 |
| Brown, S; Roy, A; Roy, M; Smelson, D; Weinberger, L | 1 |
| Hitri, A; Wyatt, RJ | 1 |
| Cohen, BM; Ennulat, DJ | 1 |
| Bell, K; Bunney, BG; Bunney, WE; Fallon, J; Keator, D; Klein, E; Najafi, A; Tang, C; Widmark, C; Wu, JC | 1 |
| Hu, XT; White, FJ; Zhang, XF | 1 |
| Pilotte, NS | 1 |
| Angelucci, L; Di Grezia, R; Orzi, F; Patacchioli, FR; Pontieri, FE | 1 |
| Ellinwood, EH; Gao, WY; King, GR; Lee, TH | 1 |
| Miczek, KA; Mutschler, NH | 2 |
| Darmani, NA; Elder, EL; Shaddy, J | 1 |
| Bowers, MB; Kosten, TR; Malison, RT; Seibyl, JP | 1 |
| Prasad, BM; Sorg, BA; Ulibarri, C | 1 |
| Kosten, TR | 2 |
| Kowell, A; Miller, BL; Stein, R; Strickland, TL | 1 |
| Hurd, YL; Svensson, P | 1 |
| Baker, DA; Coffey, GP; Fuchs, RA; Neisewander, JL; O'Dell, LE; Tran-Nguyen, LT | 1 |
| Ho, A; Kakiuchi, T; Kreek, MJ; Kreuter, J; Maggos, CE; Myers, JE; Nishiyama, S; Schlussman, SD; Tsukada, H; Unterwald, EM | 1 |
| Dalia, AD; Norman, AB; Norman, MK; Schlueter, KT; Tabet, MR; Tsibulsky, VL | 1 |
| Cheeves, C; Kosten, TR; Palumbo, J; Price, LH; Seibyl, JP; Woods, SW | 1 |
| Sarnyai, Z | 1 |
| Akimoto, T; Mizuki, Y; Suetsugi, M; Ushijima, I; Yamada, M | 1 |
| Ellinwood, EH; Gee, KR; Lee, TH; Seidler, FJ | 1 |
| Bockaert, J; Manzoni, O; Pujalte, D; Williams, J | 1 |
| Boutros, NN | 1 |
| Gorelick, DA; Henningfield, JE; Radzius, A | 1 |
| Coppola, R; Doty, L; Geyer, C; Gorey, JG; Heinz, A; Hommer, D; Jones, DW; Knable, MB; Lee, KS; Linnoila, M; Ragan, P; Weinberger, DR; Williams, W | 1 |
| Emre, N; Keys, AS; Mark, GP; Meshul, CK | 1 |
| Evans, SM; Fischman, MW; Foltin, RW; Levin, FR | 1 |
| Arroyo, M; Everitt, BJ; Markou, A; Robbins, TW | 1 |
| Briscoe, RJ; Gauvin, DV | 1 |
| Baldo, BA; Koob, GF; Markou, A | 2 |
| Gomes, PB; Macêdo, DS; Marinho, MM; Sousa, FC; Viana, GS | 1 |
| Cappendijk, SL; Hurd, YL; Nylander, I; Terenius, L; van Ree, JM | 1 |
| Alterman, AI; Boardman, CR; Kampman, K; Mulvaney, FD | 1 |
| Cumming, P; Gjedde, A; Reith, J | 1 |
| Belknap, JK; Buck, KJ; Crabbe, JC; Cunningham, CL; Phillips, TJ | 1 |
| Ahonen, A; Heikkilä, J; Hillbom, M; Laine, TP; Niemelä, O; Pyhtinen, J; Räsänen, P; Torniainen, P | 1 |
| Bhargava, HN; Kumar, S | 1 |
| Cadoni, C; Di Chiara, G | 1 |
| Barol, B; Fitzgerald, K; Katz, S; King, P; Prout, LR | 1 |
| Richter, RM; Weiss, F | 1 |
| Alper, KR | 1 |
| Binnekade, R; De Vries, TJ; Schoffelmeer, AN; Vanderschuren, LJ | 1 |
| Chawarski, MC; O'Connor, PG; Pakes, J; Schottenfeld, RS | 1 |
| Basso, AM; Koob, GF; Rivier, J; Spina, M; Vale, W | 1 |
| Pierce, RC; Pierce-Bancroft, AF; Prasad, BM | 1 |
| Arnold, JM; Bennett, SA; Chen, J; Paul, DL; Roberts, DC; Stenger, J | 1 |
| Baird, TJ; Brackett, D; Briscoe, RJ; Gauvin, DV; Lerner, MR | 1 |
| Johanson, CE; Roehrs, T; Schuh, K; Warbasse, L | 1 |
| Reith, ME; Yan, Q; Yan, S | 1 |
| Karanian, DA; Self, DW; Sutton, MA | 1 |
| Bahlmann, M; Koller, G; Preuss, UW; Soyka, M | 1 |
| Acosta, T; Ehrman, R; Gariti, P; Kampman, KM; Muller, E; O'Brien, CP; Pettinati, H; Rukstalis, M | 1 |
| Jennings, RE; Malin, DH; Moon, WD; Moy, DM; Moy, ET; Warner, RL; Wilson, OB | 1 |
| Goodman, CB; London, ED; Pilotte, NS; Sharpe, LG; Shippenberg, TS | 1 |
| Brady, KT; Killeen, TK | 1 |
| Crawford, CA; McDougall, SA; Nazarian, A; Zavala, AR | 1 |
| Cancro, R; Copersino, ML; Richarme, D; Serper, MR; Vadhan, N | 1 |
| Arroyo, M; Baker, WA; Everitt, BJ | 1 |
| Glick, SD; Maisonneuve, IM; Szumlinski, KK | 1 |
| Alterman, AI; Cornish, J; Kampman, KM; O'Brien, CP; Volpicelli, JR | 1 |
| Hammer, RP; Miczek, KA; Mutschler, NH | 1 |
| Chefer, VI; Hope, B; Morón, JA; Rea, W; Shippenberg, TS | 1 |
| Aoki, T; Kobayashi, T; Mizuki, Y; Suetsugi, M; Usami, K; Ushijima, I; Watanabe, Y | 1 |
| Dudish-Poulsen, S; Hatsukami, DK | 1 |
| Ciccocioppo, R; Sanna, PP; Weiss, F | 1 |
| Brodkin, ES; Karanian, DA; Schad, CA; Schmidt, EF; Self, DW; Sutton, MA | 1 |
| Feldon, J; Heidbreder, C; Murphy, CA | 1 |
| Acosta, T; Alterman, AI; Cnaan, A; Cornish, J; Gariti, P; Kampman, KM; Luce, D; Muller, E; Mulvaney, F; O'Brien, C; Poole, S; Volpicelli, JR | 1 |
| Covington, HE; Miczek, KA; Mutschler, NH | 1 |
| Engelhart, C; Losonczy, MF; Roy, A; Roy, M; Smelson, DA; Tershakovec, D | 1 |
| Angeletti, S; Ben-Shahar, O; Ciccocioppo, R; Katner, S; Liu, X; Parsons, LH; Richter, RR; Valdez, GR; Weiss, F; Zorrilla, EP | 1 |
| Angulo, JA; Loonam, TM; Noailles, PA; Zhang, Y | 1 |
| Altomare, K; Aston-Jones, G; Harris, GC | 1 |
| Adams, JU; Duncan, EJ; Efferen, TR; Rotrosen, J | 1 |
| Di Iorio, L; Feldon, J; Murphy, CA | 1 |
| Di Iorio, L; Feldon, J; Hédou, G; Heidbreder, CA; Pryce, C | 1 |
| Lima, VT; Macêdo, DS; Sousa, FC; Vasconcelos, SM; Viana, GS | 1 |
| De La Garza, R; Jentsch, JD; Olausson, P; Taylor, JR | 1 |
| Carreiras, T; Melloni, RH; Stellar, JR; Todtenkopf, MS | 1 |
| Berrettini, WH; Gottheil, E; Hill, KP; Patkar, AA; Sterling, RC; Weinstein, SP | 1 |
| Kela, N; Kela, P | 1 |
| Cooper, DC; White, FJ; Zhang, XF | 1 |
| France, CP; Sell, SL | 1 |
| Chefer, VI; Shippenberg, TS | 1 |
| Breiter, HC; Chabris, CF; Elman, I; Gastfriend, DR; Karlsgodt, KH | 1 |
| Castro, G; Cayse, R; Hillburn, C; King, GR; Konen, J; Love, W; Pinto, G; Tran, S | 1 |
| Khantzian, EJ; McKenna, GJ | 1 |
| Rubenstein, RB; Spira, I; Wolff, WI | 1 |
| Tepper, P; Woods, JH | 1 |
| Branch, MN | 1 |
| Burstein, Y; Giardina, PJ; Kandall, SR; Peterson, CM; Rausen, AR; Siljestrom, K | 1 |
| Evans, HE; Glass, L | 2 |
| Cottereau, MJ; Deniker, P; Lôo, H; Poirier, MF | 1 |
| Elliott, HW | 1 |
| Tgashira, E; Yanaura, S | 1 |
| Kornetsky, C; Porrino, LJ | 1 |
| Ator, NA; Brady, JV; Griffiths, RR; Sannerud, CA | 1 |
| Gorelick, DA; Herzberg, DS; Nademanee, K; Taylor, A; Wilkins, JN | 1 |
| Brown, BS; Haertzen, CC; Jaffe, JH; Kolar, AF; Michaelson, BS; Weddington, WW | 1 |
| Emil, S; Negrete, JC | 1 |
| Dennison, SJ | 1 |
| Alterman, AI; Antelo, RE; Cornish, JW; Droba, M; O'Brien, CP; Parikh, GA; Sweeney, KK | 1 |
| Koob, GF; Weiss, F | 1 |
| Azzaro, AJ; Goodman, IJ; Johnson, EA; Shahan, YH | 1 |
| Kameyama, T; Kamiya, T; Toyoshi, T; Ukai, M | 1 |
| Heninger, GR; Kleber, HD; Kosten, TR; McDougle, CJ; Palumbo, JM; Price, LH | 1 |
| Hauger, RL; Koob, GF; Markou, A | 1 |
| Koob, GF; Markou, A | 2 |
| Curtis, D; Faustman, WO; King, R; Knoblich, G; Mefford, I; Stewart, S; Zarcone, V | 1 |
| Ackerman, JM; White, FJ | 2 |
| Ellinwood, EH; Joyner, C; King, GR; Kuhn, C; Lee, T | 1 |
| Kosten, TR; Rosen, MI; Stine, S; Sullivan, MC; Wallace, EA | 1 |
| Gessa, GL; Hmaidan, Y; Rossetti, ZL | 1 |
| Eeltink, CM; van Harten, PN | 1 |
| Weddington, WW | 2 |
| Koob, GF; Lorang, MT; Markou, A; Weiss, F | 1 |
| Ellinwood, EH; Lee, TH; Zhang, H | 1 |
| Auriacombe, M; Dhopesh, V; Gariti, P; Incmikoski, R; McLellan, AT; Mezochow, J; O'Brien, C; Patterson, L; Patterson, M | 1 |
| Goldstein, S; Mindry, D; Richards, M; Sano, M; Stern, Y; Todak, G | 1 |
| Elswick, RK; Green, D; Knisely, JS; Kowatch, RA; Schnoll, SS | 1 |
| Bannon, MJ; Goebel, DJ; Kapatos, G; Xia, Y | 1 |
| Ellinwood, EH; Joyner, CM; King, G; Lee, TH; Zhang, H | 1 |
| Ashton, D; Clincke, GH; Dugovic, C; Meert, TF | 1 |
| Jones, RT | 1 |
| Childress, AR; Ehrman, R; McLellan, AT; O'Brien, CP | 2 |
| Bakos, L; Compton, P; Gawin, F; Watson, R | 1 |
| Lal, H; Prather, PL | 1 |
| Harris, GC; Williams, JT | 1 |
| Slaby, AE; Taylor, WA | 1 |
| Perper, JA; Van Thiel, DH | 1 |
| Mena, I; Mendoza, R; Miller, BL | 1 |
| Hurd, YL; Koob, GF; Markou, A; Plotsky, PM; Ungerstedt, U; Weiss, F | 1 |
| Dworkin, SI; Smith, JE | 1 |
| Carboni, S; Gessa, GL; Melis, F; Rossetti, ZL | 1 |
| Kleber, HD | 2 |
| Goodwin, FK | 1 |
| Dax, EM; De Souza, E; Mitchell, WM; Pilotte, NS; Sharpe, LG | 1 |
| McMillan, DE; Snodgrass, SH | 1 |
| Nelson, JC | 1 |
| Carlson, G; Crosby, RD; Halikas, JA | 1 |
| Gual Solé, A; Sambola Buguña, JR | 1 |
| Justice, JB; Parsons, LH; Smith, AD | 1 |
| De Souza, EB; Mitchell, WM; Pilotte, NS; Sharpe, LG | 1 |
| Coleman-Hardee, ML; Decambre, N; Peris, J; Simpkins, JW | 1 |
| Dax, EM; De Souza, EB; Mitchell, WM; Pilotte, NS; Sharpe, LG | 1 |
| Brown, BS; Cone, EJ; Dax, EM; Haertzen, CA; Herning, RI; Michaelson, BS; Weddington, WW | 2 |
| Belgrade, M; Dhuna, A; Pascual-Leone, A | 1 |
| Charney, DS; Gawin, F; Heninger, GR; Kleber, HD; Krystal, JH; McDougle, CJ; Palumbo, JM; Price, LH; Satel, SL | 1 |
| Marks, JA; Palombella, A | 1 |
| Ballenger, JC; Hutto, BR; Malcolm, R; Phillips, JD | 1 |
| Clow, DW; Hammer, RP | 1 |
| Gawin, FH | 4 |
| Bennett, JP; Leslie, CA; Robertson, MW | 1 |
| Alpert, R; Bendriem, B; Dewey, S; Fowler, JS; Hitzemann, R; Hoff, A; Volkow, ND; Wolf, AP | 1 |
| Levine, MA; Nishikawa, J | 1 |
| Elder, I; Sebastian, P; Voris, J | 1 |
| Rey-Joly, C; Urrutia, A | 1 |
| Glover, BJ; Herning, RI; Jaffe, JH; Koeppl, B; Weddington, W | 1 |
| Gawin, FH; O'Malley, SS | 1 |
| Costall, B; Jones, BJ; Kelly, ME; Naylor, RJ; Onaivi, ES; Tyers, MB | 1 |
| Ereshefsky, L; Hall, WC; Talbert, RL | 1 |
| Payte, JT; Zweben, JE | 1 |
| Giacoia, GP | 1 |
| Chiang, WK; Goldfrank, LR | 1 |
| Cooper, T; DeCaria, CM; Hollander, E; Klein, DF; Nunes, E; Quitkin, FM; Wager, S | 1 |
| Kosten, TA | 2 |
| Anthony, JC; Ritter, C; Trinkoff, AM | 1 |
| Angrist, B; Wolfsohn, R | 1 |
| Chadwick, MJ; Gregory, DL; Wendling, G | 1 |
| Kumor, K | 1 |
| Del Aguila, C; Rosman, H | 1 |
| Burke, WM; Ravi, NV | 1 |
| Costall, B; Kelly, ME; Naylor, RJ; Onaivi, ES | 2 |
| DiGregorio, GJ | 1 |
| Ehrman, RN; O'Brien, CP; Ternes, JW | 1 |
| Emmett-Oglesby, MW; Mathis, DA | 1 |
| Kosten, TA; Kosten, TR | 1 |
| Clarke, MJ | 1 |
| Giannini, AJ; Miller, NS | 1 |
| Halikas, JA; Kemp, KD; Kuhn, KL | 1 |
| Anthony, JC; Ritter, CJ; Trinkoff, AM | 1 |
| DePalma, N; Kuwada, S; O'Connor, S; Stanford, T; Tasman, A | 1 |
| Amass, L; Lukas, SE; Mendelson, J; Weiss, RD | 1 |
| Bianchi, MS; Kosten, TA; Kosten, TR | 1 |
| Extein, IL; Gold, MS; Gross, DA | 1 |
| Ellinwood, EH; Gawin, FH | 1 |
| Feather, JN; Folts, DJ; Giannini, AJ; Sullivan, BS | 1 |
| Aceto, MD; Balster, RL; Beardsley, PM; Harris, LS; Knisely, JS | 1 |
| Dougherty, RJ; Lesswing, NJ | 1 |
| Choy-Kwong, M; Lipton, RB; Solomon, S | 1 |
| Choy-Kwong, M; Lipton, RB | 1 |
| Durand, DJ; Fulroth, R; Phillips, B | 1 |
| Galloway, MP; Lodhi, R; Martin, SD; Yeragani, VK | 1 |
| Gorelick, DA; Intarachot, V; Josephson, MA; Mody, FV; Nademanee, K; Robertson, HA; Ryan, MA; Wilkins, JN | 1 |
| Dackis, CA; Gold, MS; Pottash, AL | 1 |
| Jenner, FA; Liappas, IA; Vicente, B | 1 |
| Finstuen, K; Henneberger, JT; Menk, EJ; Middaugh, RE | 1 |
| Ketter, TA; Lannon, RA; Louie, AK | 1 |
| Griffin, ML; Lange, U; Mirin, SM; Weiss, RD | 1 |
| Pike, RF | 1 |
| Lyman, JL; Mohler, SR | 1 |
| Devenyi, P; Teller, DW | 1 |
| Childress, AR; Ehrman, RN; McLellan, AT; O'Brien, CP | 1 |
| Liu, SJ; Wang, RI | 1 |
| Lange, U; Mello, N; Mendelson, J; Skupny, A; Teoh, S; Weiss, R | 1 |
| Gawin, F; Kleber, H; Kosten, T; Morgan, C | 1 |
| Kantak, KM; Miczek, KA | 1 |
| Beresford, TP; Blow, FC; Brower, KJ; Maddahian, E | 1 |
| Golwyn, DH | 1 |
| Baumgartel, P; DiMarzio, LR; Giannini, AJ | 1 |
| Net, A; Rello, J | 1 |
| Richter, RW; Stanitis, T | 1 |
| Bouknight, LG; Bouknight, RR | 1 |
| Berman, ML; Tennant, F | 1 |
| Barnes, DM | 1 |
| Baldessarini, RJ; Campbell, A; Cremens, MC; Gutierrez-Esteinou, R; Teicher, MH | 1 |
| Giannini, AJ; Giannini, MC; Loiselle, RH | 1 |
| Giannini, AJ; Giannini, MC; Loiselle, RH; Malone, DA; Price, WA | 1 |
| Sagherian, AA; Tennant, FS | 1 |
| Hakkei, M; Kubota, A; Kuwahara, A; Nakamura, K | 1 |
| Carroll, ME; Lac, ST | 1 |
| Gold, MS; Lehrer, M | 1 |
| Lal, H; Wood, DM | 1 |
| Clore, ER; Nichols, CE | 1 |
| Ahmed, I; Kulick, AR | 1 |
| Gold, MS; Pottash, AC; Washton, AM | 2 |
| Bingol, N; Diaz, V; Fuchs, M; Gromisch, DS; Stone, RK | 1 |
| Brower, KJ; Paredes, A | 1 |
| Dackis, CA; Gold, MS; Sweeney, DR | 1 |
| Gazaway, PM; Mullins, CL | 1 |
| Miller, GW | 1 |
| Gawin, FH; Kleber, HD | 1 |
| Newald, J | 1 |
| Purcell, JJ; Small, GW | 1 |
| Bewley, T | 1 |
| Marlow, HF | 1 |
| Wurmser, L | 1 |
| Bläsig, J; Herz, A; Papeschi, R | 1 |
| Tagashira, E; Yanaura, S | 1 |
| Bläsig, J; Herz, A | 1 |
| Stiksrud, HA; Süllwold, L | 1 |
| Funk, F | 1 |
| Glatt, MM; Lewis, DM; Wilson, DT | 1 |
| Fraser, HF; Gorodetzky, CW; Martin, WR; Rosenberg, DE | 1 |
| Cohen, MI; Litt, IF | 1 |
| Paton, WD | 1 |
| Gubert, C; Kapczinski, F; Kessler, FH; Ornell, F; Pechansky, F; Pfaffenseller, B; Salum, GA; Schuch, S; Sordi, AO; von Diemen, L; Wollenhaupt-Aguiar, B | 1 |
| Galland, F; Hansen, F; Ligabue, K; Scherer, JN; Schuch, JB; Silvello, D; Sordi, AO; von Diemen, L | 1 |
| Aita, CAM; da Silva, B; de Bem Silveira, G; Hamerski, HM; Hirsch, GE; Jaskulski, M; Klafke, JZ; Kroker, K; Porto, FG; Santos, GT; Silveira, PCL; Viecili, PRN | 1 |
| Berry, AJ | 1 |
| Alonso-Matias, L; Gonzalez-Olvera, JJ; Reyes-Zamorano, E | 1 |
| Francke, ID; Grassi-Oliveira, R; Tractenberg, SG; Viola, TW | 1 |
| de Aguiar, BW; de Magalhães Narvaez, JC; de Moura Gubert, C; Guimarães, LS; Kapczinski, F; Kessler, FH; Pechansky, F; Pfaffenseller, B; Sordi, AO; von Diemen, L | 1 |
| Bauer, ME; Grassi-Oliveira, R; Levandowski, ML; Pezzi, JC; Teixeira, AL; Tractenberg, SG; Viola, TW | 1 |
| Bauer, ME; Brietzke, E; Grassi-Oliveira, R; Levandowski, ML; Teixeira, AL; Tractenberg, SG; Viola, TW; Wearick-Silva, LE; Wieck, A | 1 |
| de Aguiar, BW; de Magalhães Narvaez, JC; Gubert, C; Kapczinski, F; Kessler, FH; Ornell, F; Pechansky, F; Pfaffenseller, B; Sordi, AO; von Diemen, L | 1 |
| Bauer, ME; da Silva Morrone, M; Grassi-Oliveira, R; Moreira, JC; Viola, TW; Zaparte, A | 1 |
| Aroche, AP; Bau, CHD; da Silva, BS; de Almeida, RMM; Grassi-Oliveira, R; Hess, ARB; Kappel, DB; Levandowski, ML; Pezzi, JC; Rovaris, DL; Schuch, JB | 1 |
| Badin de Montjoye, B; Pharo, P; Podevin, P | 1 |
| Cunha, PJ; Gomes, LP; Moino, RM; Nicastri, S; Peluso, MA | 1 |
| D'Alberto, A | 1 |
| Ogle, K | 1 |
| Edgar, C; Hart, CL; Malison, RT; Morgan, PT; Pace-Schott, EF; Stickgold, R; Walker, M | 1 |
| Bowser, B; Edlin, BR; Faruque, S; Holmberg, SD; Inciardi, J; Irwin, KL; McCoy, HV; Serrano, Y; Word, C | 1 |
| Carson, WH; Finkenbine, R; King, L; Markowitz, JS; Myrick, H | 1 |
| Berger, SP; Delucchi, KL; Hall, SM; Mickalian, JD; Reid, MS | 1 |
| Alper, KR; John, ER; Kowalik, S; Prichep, LS; Rosenthal, MS | 1 |
| Foltin, RW; Gerra, G; Haney, M; Ward, AS | 1 |
| Carlson, GA; Crea, FS; Crosby, R; Halikas, JA; Kuhn, KL | 1 |
85 review(s) available for cocaine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Clinical management of psychostimulant withdrawal: review of the evidence.
Topics: Amphetamine-Related Disorders; Central Nervous System Stimulants; Cocaine; Humans; Methamphetamine; Substance Withdrawal Syndrome | 2023 |
Anti-cocaine Vaccine Development: Where Are We Now and Where Are We Going?
Topics: Cocaine; Cocaine-Related Disorders; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders; Vaccines | 2023 |
[Neural circuits and neurotransmitters involved in the effects of psychoactive drugs - State of the art with a focus on cocaine].
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Humans; Nerve Net; Neurotransmitter Agents; Psychotropic Drugs; Signal Transduction; Substance Withdrawal Syndrome; Synaptic Transmission | 2019 |
The role of mitochondria in cocaine addiction.
Topics: Animals; Antioxidants; Brain; Cocaine; Cocaine-Related Disorders; Energy Metabolism; Female; Glycolysis; Humans; Mice; Mitochondria; Mitochondrial Transmembrane Permeability-Driven Necrosis; Mitochondrial Turnover; Neuroglia; Organelle Biogenesis; Oxidative Phosphorylation; Oxidative Stress; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rats; Reactive Oxygen Species; Reward; Substance Withdrawal Syndrome | 2021 |
Modulation of drug choice by extended drug access and withdrawal in rhesus monkeys: Implications for negative reinforcement as a driver of addiction and target for medications development.
Topics: Animals; Choice Behavior; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Food; Heroin; Heroin Dependence; Humans; Macaca mulatta; Narcotic Antagonists; Opioid-Related Disorders; Reinforcement, Psychology; Substance Withdrawal Syndrome | 2018 |
Kinase interest you in treating incubated cocaine-craving? A hypothetical model for treatment intervention during protracted withdrawal from cocaine.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Craving; Cues; Drug-Seeking Behavior; Excitatory Amino Acid Agents; Extinction, Psychological; Glutamic Acid; Humans; MAP Kinase Signaling System; Mice; Prefrontal Cortex; Protein Kinase C; Rats; Substance Withdrawal Syndrome; Withholding Treatment | 2018 |
Antipsychotics for cocaine or psychostimulant dependence: systematic review and meta-analysis of randomized, placebo-controlled trials.
Topics: Amphetamine-Related Disorders; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Humans; Methamphetamine; Olanzapine; Outcome Assessment, Health Care; Piperazines; Quinolones; Randomized Controlled Trials as Topic; Risperidone; Substance Withdrawal Syndrome; Synaptic Transmission; Treatment Outcome | 2013 |
Cocaine self-administration causes signaling deficits in corticostriatal circuitry that are reversed by BDNF in early withdrawal.
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Agents; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Humans; Neural Pathways; Self Administration; Substance Withdrawal Syndrome | 2015 |
Modafinil: a useful medication for cocaine addiction? Review of the evidence from neuropharmacological, experimental and clinical studies.
Topics: Animals; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Combined Modality Therapy; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Induction; Humans; Metabolic Clearance Rate; Modafinil; Motivation; Neurotransmitter Agents; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome; Treatment Outcome | 2008 |
Evaluation of the relationship between anxiety during withdrawal and stress-induced reinstatement of cocaine seeking.
Topics: Animals; Anxiety; Brain; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Dopamine; Humans; Norepinephrine; Rats; Recurrence; Self Administration; Stress, Psychological; Substance Withdrawal Syndrome | 2010 |
Behavioral evidence for the significance of serotoninergic (5-HT) receptors in cocaine addiction.
Topics: Animals; Appetitive Behavior; Association Learning; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Consummatory Behavior; Discrimination, Psychological; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Emotions; Euphoria; Humans; Motivation; Norepinephrine Plasma Membrane Transport Proteins; Rats; Receptors, Serotonin; Self Administration; Substance Withdrawal Syndrome | 2010 |
Cocaine-induced metaplasticity in the nucleus accumbens: silent synapse and beyond.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Humans; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Nucleus Accumbens; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Up-Regulation | 2011 |
Vocalizations during withdrawal from opiates and cocaine: possible expressions of affective distress.
Topics: Animals; Anxiety; Cocaine; Narcotics; Substance Withdrawal Syndrome; Ultrasonics; Vocalization, Animal | 2003 |
Drug addiction.
Topics: Animals; Cannabinoids; Cocaine; Disease Models, Animal; Dopamine; Ethanol; Humans; Narcotics; Nicotine; Recurrence; Reinforcement, Psychology; Substance Withdrawal Syndrome; Substance-Related Disorders | 2003 |
Anticonvulsant drugs in the treatment of substance withdrawal.
Topics: Alcohol Withdrawal Delirium; Anticonvulsants; Benzodiazepines; Cocaine; Ethanol; Humans; Narcotics; Substance Withdrawal Syndrome | 2004 |
Cocaine withdrawal and neuro-adaptations in ion channel function.
Topics: Adaptation, Physiological; Animals; Calcium; Cocaine; Dopamine; Humans; Ion Channels; Neurons; Prefrontal Cortex; Receptors, Dopamine; Reward; Signal Transduction; Substance Withdrawal Syndrome | 2007 |
The effects of cocaine: a shifting target over the course of addiction.
Topics: Animals; Brain; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Humans; Substance Withdrawal Syndrome | 2007 |
Effect of illicit recreational drugs upon sleep: cocaine, ecstasy and marijuana.
Topics: Animals; Brain; Cocaine; Disease Models, Animal; Dronabinol; Humans; Illicit Drugs; N-Methyl-3,4-methylenedioxyamphetamine; Polysomnography; Sleep; Sleep Stages; Substance Withdrawal Syndrome; Substance-Related Disorders | 2008 |
Drug-induced psychiatric disorders.
Topics: Alcoholic Intoxication; Alcoholism; Amphetamines; Analgesics; Antihypertensive Agents; Antiparkinson Agents; Antitubercular Agents; Barbiturates; Bromides; Cannabis; Cocaine; Hallucinations; Histamine H1 Antagonists; Humans; Lysergic Acid Diethylamide; Mental Disorders; Parasympatholytics; Psychotropic Drugs; Steroids; Substance Withdrawal Syndrome | 1981 |
New insights and treatments: opiate withdrawal and cocaine addiction.
Topics: Brain Chemistry; Clonidine; Cocaine; Dopamine; Humans; Methadone; Naltrexone; Norepinephrine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
The tonic/phasic model of dopamine system regulation: its relevance for understanding how stimulant abuse can alter basal ganglia function.
Topics: Amphetamines; Animals; Autoreceptors; Basal Ganglia; Cocaine; Dose-Response Relationship, Drug; Homeostasis; Receptors, Dopamine; Substance Withdrawal Syndrome; Substance-Related Disorders; Synaptic Transmission | 1995 |
Management of drug dependency, overdose, and withdrawal in the obstetric patient.
Topics: Cocaine; Drug Overdose; Ethanol; Female; Fetus; Humans; Mass Screening; Pregnancy; Pregnancy Complications; Prevalence; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Stimulant withdrawal.
Topics: Affect; Amphetamines; Animals; Arousal; Brain; Cocaine; Dopamine; Humans; Neurologic Examination; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
[Neurobiological principles of drug dependence. Exemplified by opioids and psychostimulants].
Topics: Amphetamines; Animals; Cocaine; Humans; Limbic System; Mesencephalon; Motivation; Neural Pathways; Neurotransmitter Agents; Opioid-Related Disorders; Receptors, Dopamine D1; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Medical consequences of cocaine.
Topics: Adrenergic alpha-Antagonists; Adult; Cocaine; Comorbidity; Female; Humans; Infant, Newborn; Male; North America; Pregnancy; Referral and Consultation; Social Problems; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Cocaine: friend or foe? (Part 1).
Topics: Brain; Cocaine; Digestive System; Female; Heart; Humans; Kidney; Male; Reproduction; Respiratory System; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
The economic context of drug and non-drug reinforcers affects acquisition and maintenance of drug-reinforced behavior and withdrawal effects.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Humans; Illicit Drugs; Macaca mulatta; Motivation; Phencyclidine Abuse; Psychotropic Drugs; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Medications development at the National Institute on Drug Abuse: focus on cocaine.
Topics: Bromocriptine; Cocaine; Desipramine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Cocaine and the nervous system.
Topics: Acute Disease; Animals; Central Nervous System; Cocaine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
The treatment of cocaine abuse.
Topics: Arousal; Cocaine; Combined Modality Therapy; Comorbidity; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Seizures.
Topics: Amphetamines; Cocaine; Epilepsy; Ethanol; Humans; Infant, Newborn; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Movement disorders.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alcoholism; Amphetamines; Cocaine; Dyskinesia, Drug-Induced; Humans; Movement Disorders; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Cocaine abuse in North America: a milestone in history.
Topics: Cardiovascular System; Cocaine; Digestive System; Drug and Narcotic Control; Europe; History, 19th Century; History, 20th Century; Humans; Nervous System; North America; Substance Withdrawal Syndrome; Substance-Related Disorders; Urogenital System | 1993 |
Drug addiction: the yin and yang of hedonic homeostasis.
Topics: Amphetamine; Amygdala; Brain; Cocaine; Drug Tolerance; Homeostasis; Humans; Narcotics; Neuropeptides; Nicotine; Receptors, Dopamine; Reinforcement, Psychology; Substance Withdrawal Syndrome; Substance-Related Disorders | 1996 |
Neurobiological mechanisms underlying the acquisition and expression of incentive motivation by cocaine-associated stimuli: relationship to craving.
Topics: Animals; Cocaine; Conditioning, Operant; Disease Models, Animal; Feeding Behavior; Humans; Motivation; Motor Activity; Neurobiology; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Cocaine reward and cocaine craving: the role of dopamine in perspective.
Topics: Animals; Brain; Cocaine; Dopamine; Dopamine Agonists; Humans; Reward; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Neurochemical changes in cocaine withdrawal.
Topics: Animals; Brain Chemistry; Cocaine; Disease Models, Animal; Dopamine; Drug Design; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Neurons; Nucleus Accumbens; Substance Withdrawal Syndrome; Synapses | 1996 |
Cocaine withdrawal alters regulatory elements of dopamine neurons.
Topics: Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Narcotics; Nerve Tissue Proteins; Neurons; Substance Withdrawal Syndrome | 1996 |
Is craving mood-driven or self-propelled? Sensitization and "street" stimulant addiction.
Topics: Affect; Animals; Central Nervous System Stimulants; Cocaine; Euphoria; Humans; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1996 |
Chronic cocaine use as a neuropsychiatric syndrome: a model for debate.
Topics: Cocaine; Humans; Mental Disorders; Narcotics; Substance Withdrawal Syndrome; Substance-Related Disorders; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 1996 |
Neurochemistry of cocaine withdrawal.
Topics: Animals; Brain Chemistry; Cocaine; Dopamine; Humans; Narcotics; Substance Withdrawal Syndrome | 1997 |
Pharmacotherapy of cerebral ischemia in cocaine dependence.
Topics: Aspirin; Brain; Brain Ischemia; Cerebrovascular Circulation; Cocaine; Cocaine-Related Disorders; Cognition Disorders; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Intracranial Embolism and Thrombosis; Male; Nerve Degeneration; Neuropsychological Tests; Platelet Aggregation Inhibitors; Radionuclide Imaging; Substance Withdrawal Syndrome | 1998 |
Neurobiology of cocaine-induced organic brain impairment: contributions from functional neuroimaging.
Topics: Brain Ischemia; Cerebral Cortex; Cerebral Hemorrhage; Cerebrovascular Circulation; Cerebrovascular Disorders; Cocaine; Cocaine-Related Disorders; Cognition Disorders; Dopamine Uptake Inhibitors; Electroencephalography; Glucose; Humans; Substance Withdrawal Syndrome; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Vasoconstrictor Agents | 1998 |
Neurobiology of stress and cocaine addiction. Studies on corticotropin-releasing factor in rats, monkeys, and humans.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Haplorhini; Humans; Hypothalamus; Pituitary-Adrenal System; Rats; Stress, Physiological; Substance Withdrawal Syndrome; Substance-Related Disorders | 1998 |
Identifying genes for alcohol and drug sensitivity: recent progress and future directions.
Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Chromosome Mapping; Cocaine; Crosses, Genetic; Ethanol; Female; Forecasting; Genetic Predisposition to Disease; Humans; Lod Score; Male; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Mice, Knockout; Morphine; Pentobarbital; Quantitative Trait, Heritable; Substance Withdrawal Syndrome; Substance-Related Disorders | 1999 |
The EEG and cocaine sensitization: a hypothesis.
Topics: Brain; Cocaine; Electroencephalography; Humans; Substance Withdrawal Syndrome | 1999 |
[Treatment of cocaine dependence. Intoxication, withdrawal and prevention of relapse].
Topics: Cocaine; Cocaine-Related Disorders; Drug Overdose; Humans; Secondary Prevention; Substance Withdrawal Syndrome | 2000 |
Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors.
Topics: Adaptation, Physiological; Affect; Animals; Central Nervous System Depressants; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Disease Models, Animal; Dopamine Uptake Inhibitors; Ethanol; Humans; Nucleus Accumbens; Receptors, Dopamine; Receptors, Serotonin; Recurrence; Reinforcement, Psychology; Stress, Psychological; Substance Withdrawal Syndrome; Substance-Related Disorders | 2001 |
Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Methamphetamine; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substantia Nigra | 2001 |
Acute toxic and withdrawal reactions associated with drug use and abuse.
Topics: Alcoholic Intoxication; Alcoholism; Amphetamines; Analgesics, Opioid; Barbiturates; Benzodiazepines; Cannabinoids; Cocaine; Glutethimide; Hallucinogens; Humans; Hypnotics and Sedatives; Lysergic Acid Diethylamide; Phencyclidine; Substance Withdrawal Syndrome; Substance-Related Disorders; Toxicology | 1979 |
Brain mechanisms of drug-induced reinforcement.
Topics: Animals; Brain; Cocaine; Morphine; Motivation; Psychotropic Drugs; Rats; Receptors, Dopamine; Receptors, Opioid; Reinforcement, Psychology; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Neurobiological mechanisms in cocaine and opiate dependence.
Topics: Animals; Brain; Cocaine; Dopamine; Humans; Motivation; Opioid-Related Disorders; Self Stimulation; Substance Withdrawal Syndrome; Substance-Related Disorders; Synaptic Transmission | 1992 |
Neuropharmacology of cocaine and ethanol dependence.
Topics: Alcoholism; Animals; Brain; Cocaine; Ethanol; Humans; Motivation; Neurotransmitter Agents; Receptors, Neurotransmitter; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
What have we learned from nicotine, cocaine, and marijuana about addiction?
Topics: Brain; Cannabinoids; Cocaine; Humans; Marijuana Abuse; Nicotine; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Acute treatment of alcohol and cocaine emergencies.
Topics: Alcoholism; Cocaine; Emergencies; Ethanol; Humans; Neurologic Examination; Psychoses, Substance-Induced; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Cardiovascular complications of cocaine abuse.
Topics: Cardiovascular Diseases; Cocaine; Humans; Risk Factors; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Emergency room evaluation of cocaine-associated neuropsychiatric disorders.
Topics: Brain Damage, Chronic; Cocaine; Dose-Response Relationship, Drug; Emergency Service, Hospital; Humans; Neurologic Examination; Psychoses, Substance-Induced; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Neural mechanisms of drug reinforcement.
Topics: Animals; Brain; Cocaine; Humans; Models, Neurological; Narcotics; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Neurochemical correlates of cocaine and ethanol self-administration.
Topics: Animals; Cocaine; Dopamine; Ethanol; Nucleus Accumbens; Rats; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Cortical regulation of self-administration.
Topics: Animals; Brain; Cerebral Cortex; Cocaine; Glucose; Humans; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Classical conditioning in drug-dependent humans.
Topics: Animals; Cocaine; Conditioning, Classical; Drug Tolerance; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Treatment of cocaine abuse: pharmacotherapy.
Topics: Cocaine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Pharmacotherapeutic interventions for cocaine abuse: present practices and future directions.
Topics: Antipsychotic Agents; Benzodiazepines; Carbamazepine; Cocaine; Dopamine Agents; Humans; Recurrence; Serotonin Antagonists; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Addictiveness of central stimulants.
Topics: Amphetamines; Central Nervous System Stimulants; Cocaine; Euphoria; Humans; Methylphenidate; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Cocaine addiction: psychology and neurophysiology.
Topics: Cocaine; Humans; Models, Psychological; Nervous System; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
[Medical problems caused by cocaine].
Topics: Cocaine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Abstinence symptomatology and neuropsychological impairment in chronic cocaine abusers.
Topics: Cocaine; Emotions; Humans; Neuropsychological Tests; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Cocaine abuse and its treatment.
Topics: Animals; Central Nervous System; Cocaine; Dopamine; History, 19th Century; History, 20th Century; Humans; Mesencephalon; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Methadone maintenance in the treatment of opioid dependence. A current perspective.
Topics: Acquired Immunodeficiency Syndrome; Attitude of Health Personnel; Cocaine; Drug Interactions; Ethanol; Female; Heroin Dependence; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Substance Withdrawal Syndrome | 1990 |
Cocaine in the cradle: a hidden epidemic.
Topics: Child Behavior Disorders; Child, Preschool; Cocaine; Disease Outbreaks; Female; Fetal Diseases; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Socioeconomic Factors; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Substance withdrawal.
Topics: Ambulatory Care; Cocaine; Ethanol; Humans; Hypnotics and Sedatives; Infant, Newborn; Opium; Substance Withdrawal Syndrome | 1990 |
Cocaine update: abuse and therapy.
Topics: Cocaine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Cocaine dependence.
Topics: Animals; Cocaine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Cocaine abuse and addiction.
Topics: Cocaine; Humans; Primary Health Care; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Withdrawal syndromes.
Topics: Barbiturates; Benzodiazepines; Central Nervous System Stimulants; Cocaine; Ethanol; Female; Humans; Infant, Newborn; Narcotics; Substance Withdrawal Syndrome | 1987 |
New concepts in cocaine addiction: the dopamine depletion hypothesis.
Topics: Animals; Brain; Cocaine; Conditioning, Operant; Dopamine; Euphoria; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Mice; Models, Neurological; Models, Psychological; Prolactin; Rats; Reward; Serotonin; Substance Withdrawal Syndrome; Substance-Related Disorders; Synaptic Transmission; Thyroid Gland; Thyrotropin-Releasing Hormone | 1985 |
Chronic neuropharmacology of cocaine: progress in pharmacotherapy.
Topics: Amphetamine; Animals; Behavior, Animal; Cocaine; Dopamine; Humans; Methylphenidate; Psychotherapy; Reward; Self Stimulation; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
Laboratory assessments in treatments of substance abuse: utilization and effects on treatment design.
Topics: Body Fluids; Cocaine; Humans; Laboratories; Psychotropic Drugs; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
[Medical complications caused by cocaine consumption].
Topics: Administration, Intranasal; Cardiovascular Diseases; Cocaine; Humans; Injections, Intravenous; Mental Disorders; Spain; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
The neurologist's approach to alcoholism and drug abuse: outpatient care.
Topics: Alcoholism; Ambulatory Care; Cocaine; Humans; Narcotics; Neurology; Outpatient Clinics, Hospital; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
The cocaine habit.
Topics: Adult; Cocaine; Humans; Male; Physician's Role; Physicians, Family; Substance Withdrawal Syndrome; Substance-Related Disorders | 1985 |
Pharmacological approaches to cocaine addiction.
Topics: Brain Chemistry; Bromocriptine; Cocaine; Desipramine; Dopamine; Euphoria; Humans; Receptors, Dopamine; Reward; Substance Withdrawal Syndrome; Substance-Related Disorders; Tyrosine | 1985 |
[Neurobiologic aspects of the morphine addictions].
Topics: Acetylcholine; Amphetamine; Animals; Apomorphine; Brain Chemistry; Catecholamines; Cocaine; Desipramine; Dopamine; Drug Antagonism; Drug Interactions; Drug Synergism; Drug Tolerance; Guinea Pigs; Humans; Mice; Models, Biological; Morphine; Morphine Dependence; Rats; Receptors, Drug; Serotonin; Substance Withdrawal Syndrome | 1974 |
Cognitive functions of subjects with cocaine and crack dependency disorder during early abstinence.
Topics: Adult; Alcoholism; Cocaine-Related Disorders; Cognition; Cognition Disorders; Crack Cocaine; Craving; Cross-Sectional Studies; Executive Function; Female; Gambling; Humans; Impulsive Behavior; Male; Memory, Short-Term; Mexico; Neuropsychological Tests; Socioeconomic Factors; Substance Withdrawal Syndrome; Theory of Mind | 2019 |
Auricular acupuncture in the treatment of cocaine/crack abuse: a review of the efficacy, the use of the National Acupuncture Detoxification Association protocol, and the selection of sham points.
Topics: Acupuncture Points; Acupuncture, Ear; Adult; Behavior, Addictive; Cocaine-Related Disorders; Crack Cocaine; Europe; Humans; Randomized Controlled Trials as Topic; Research Design; Substance Withdrawal Syndrome; Treatment Outcome; United Kingdom | 2004 |
71 trial(s) available for cocaine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Treatment of Toxin-Related Status Epilepticus With Levetiracetam, Fosphenytoin, or Valproate in Patients Enrolled in the Established Status Epilepticus Treatment Trial.
Topics: Adult; Alcoholism; Analgesics, Opioid; Anticonvulsants; Benzodiazepines; Child; Cocaine; Female; Humans; Levetiracetam; Male; Phenytoin; Prospective Studies; Seizures; Status Epilepticus; Substance Withdrawal Syndrome; Valproic Acid | 2022 |
Correlates of polysomnographic sleep changes in cocaine dependence: self-administration and clinical outcomes.
Topics: Adult; Anesthetics, Local; Cocaine; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Polysomnography; Self Administration; Sleep Wake Disorders; Substance Abuse Detection; Substance Withdrawal Syndrome | 2014 |
Effects of a Single Lyric Analysis Intervention on Withdrawal and Craving With Inpatients on a Detoxification Unit: A Cluster-Randomized Effectiveness Study.
Topics: Adult; Alcoholism; Central Nervous System Depressants; Cocaine; Cocaine-Related Disorders; Craving; Dopamine Uptake Inhibitors; Ethanol; Female; Heroin; Heroin Dependence; Humans; Male; Middle Aged; Music Therapy; Narcotics; Psychotherapy, Group; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome; Young Adult | 2016 |
Sleep architecture, cocaine and visual learning.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Cognition; Female; Humans; Learning; Male; Middle Aged; Narcotics; Polysomnography; Self Administration; Sleep, REM; Substance Withdrawal Syndrome; Time Factors; Visual Perception; Young Adult | 2008 |
A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion.
Topics: Administration, Cutaneous; Adult; Affect; Amphetamine; Amphetamines; Analysis of Variance; Cocaine; Dopamine Uptake Inhibitors; Drug Interactions; Female; Homovanillic Acid; Humans; Infusions, Intravenous; Male; Methamphetamine; Methoxyhydroxyphenylglycol; Monitoring, Physiologic; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Prolactin; Selegiline; Statistics, Nonparametric; Substance Withdrawal Syndrome; Young Adult | 2009 |
Repeated dosing with oral cocaine in humans: assessment of direct effects, withdrawal, and pharmacokinetics.
Topics: Administration, Oral; Adult; Behavior, Addictive; Cocaine; Drug Administration Schedule; Female; Hemodynamics; Humans; Male; Prolactin; Sleep Wake Disorders; Substance Withdrawal Syndrome; Time Factors | 2009 |
Normalizing effects of modafinil on sleep in chronic cocaine users.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Humans; Male; Middle Aged; Modafinil; Polysomnography; Sleep Wake Disorders; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Wakefulness | 2010 |
Sustained release d-amphetamine reduces cocaine but not 'speedball'-seeking in buprenorphine-maintained volunteers: a test of dual-agonist pharmacotherapy for cocaine/heroin polydrug abusers.
Topics: Adolescent; Adult; Buprenorphine; Choice Behavior; Cocaine; Cocaine-Related Disorders; Delayed-Action Preparations; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Seeking Behavior; Female; Humans; Hydromorphone; Male; Middle Aged; Narcotic Antagonists; Opioid-Related Disorders; Reinforcement Schedule; Reward; Substance Withdrawal Syndrome | 2010 |
Acoustic startle reduction in cocaine dependence persists for 1 year of abstinence.
Topics: Acoustic Stimulation; Blinking; Cocaine; Cocaine-Related Disorders; Electromyography; Female; Humans; Male; Middle Aged; Reaction Time; Recurrence; Sensory Gating; Substance Withdrawal Syndrome | 2011 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Female; GABA Agonists; Humans; Louisiana; Male; Metyrapone; Middle Aged; Oxazepam; Patient Compliance; Patient Dropouts; Pilot Projects; Secondary Prevention; Steroid 11-beta-Hydroxylase; Substance Withdrawal Syndrome | 2012 |
A double-blind, placebo-controlled trial of modafinil for cocaine dependence.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Combined Modality Therapy; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Modafinil; Sex Factors; Substance Withdrawal Syndrome; Treatment Outcome; Young Adult | 2012 |
Effects of intravenous cocaine and cigarette smoking on luteinizing hormone, testosterone, and prolactin in men.
Topics: Carbon Monoxide; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Humans; Luteinizing Hormone; Male; Nicotine; Prolactin; Smoking; Substance Withdrawal Syndrome; Testosterone | 2003 |
DHEAS and POMS measures identify cocaine dependence treatment outcome.
Topics: Adult; Affect; Cocaine; Cocaine-Related Disorders; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Hydrocortisone; Male; Middle Aged; Predictive Value of Tests; Prolactin; Psychiatric Status Rating Scales; Substance Abuse Detection; Substance Withdrawal Syndrome; Treatment Outcome | 2005 |
A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms.
Topics: Adrenergic beta-Antagonists; Adult; Amantadine; Analgesics, Non-Narcotic; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Neurologic Examination; Patient Dropouts; Propranolol; Substance Abuse Detection; Substance Withdrawal Syndrome | 2006 |
Heroin and cocaine craving and use during treatment: measurement validation and potential relationships.
Topics: Adult; Ambulatory Care; Cocaine; Cocaine-Related Disorders; Female; Heroin; Heroin Dependence; Humans; Male; Middle Aged; Motivation; Pain Measurement; Patient Dropouts; Personality Inventory; Psychometrics; Recurrence; Reproducibility of Results; Self Efficacy; Statistics as Topic; Substance Abuse Detection; Substance Withdrawal Syndrome; Surveys and Questionnaires; Treatment Refusal | 2006 |
Cocaine withdrawal symptoms predict medication response in cocaine users.
Topics: Cocaine; Cocaine-Related Disorders; Double-Blind Method; Female; GABA Agents; Humans; Male; Outpatients; Placebos; Predictive Value of Tests; Substance Withdrawal Syndrome; Treatment Outcome | 2006 |
Effects of combined fluoxetine and counseling in the outpatient treatment of cocaine abusers.
Topics: Adult; Ambulatory Care; Antidepressive Agents, Second-Generation; Cocaine; Combined Modality Therapy; Counseling; Diphenhydramine; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans; Hypnotics and Sedatives; Male; Middle Aged; Substance Abuse Detection; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Absence of acute cocaine interactions with the MAO-B inhibitor selegiline.
Topics: Administration, Oral; Adult; Arousal; Blood Pressure; Cocaine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Euphoria; Heart Rate; Humans; Infusions, Intravenous; Male; Monoamine Oxidase Inhibitors; Reflex, Pupillary; Selegiline; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Effects of type of exercise on depression in recovering substance abusers.
Topics: Adolescent; Adult; Alcoholism; Cocaine; Depression; Exercise; Female; Humans; Internal-External Control; Male; Middle Aged; Personality Inventory; Physical Fitness; Self Concept; Substance Withdrawal Syndrome; Substance-Related Disorders; Weight Lifting | 1995 |
The Matrix model of outpatient stimulant abuse treatment: evidence of efficacy.
Topics: Adult; Ambulatory Care; Cocaine; Combined Modality Therapy; Desipramine; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Methamphetamine; Neurologic Examination; Patient Care Team; Socioenvironmental Therapy; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome | 1994 |
Neurobehavioral treatment for cocaine-using methadone patients: a preliminary report.
Topics: Adult; Ambulatory Care; Cocaine; Cognitive Behavioral Therapy; Combined Modality Therapy; Comorbidity; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Neuropsychological Tests; Personality Assessment; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome | 1994 |
Imipramine for the treatment of cocaine and methamphetamine dependence.
Topics: Cocaine; Combined Modality Therapy; Counseling; Dose-Response Relationship, Drug; Double-Blind Method; Feasibility Studies; Female; Follow-Up Studies; Humans; Imipramine; Male; Methamphetamine; Patient Dropouts; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome | 1994 |
Methadone dosing and pregnancy: impact on program compliance.
Topics: Ambulatory Care; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infant, Newborn; Methadone; Opioid-Related Disorders; Patient Compliance; Pregnancy; Pregnancy Complications; Substance Abuse Detection; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Double-blind comparison of bromocriptine and placebo in cocaine withdrawal.
Topics: Adult; Bromocriptine; Cocaine; Double-Blind Method; Growth Hormone; Humans; Male; Middle Aged; Multivariate Analysis; Prolactin; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Treatment Outcome; Veterans | 1995 |
Reduction of opiate withdrawal-like symptoms by cocaine abuse during methadone and buprenorphine maintenance.
Topics: Adult; Buprenorphine; Cocaine; Comorbidity; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methadone; Neurologic Examination; Opioid-Related Disorders; Substance Abuse Detection; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
The effects of lisuride on mood and sleep during acute withdrawal in stimulant abusers: a preliminary report.
Topics: Administration, Oral; Adult; Affect; Brain; Cocaine; Crack Cocaine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Humans; Male; Methamphetamine; Middle Aged; Neurologic Examination; Receptors, Dopamine; Sleep, REM; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Noradrenergic dysregulation during discontinuation of cocaine use in addicts.
Topics: Administration, Intranasal; Adult; Cocaine; Double-Blind Method; Female; Hospitalization; Humans; Hydrocortisone; Infusions, Intravenous; Insufflation; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Panic Disorder; Prospective Studies; Single-Blind Method; Substance Withdrawal Syndrome; Substance-Related Disorders; Yohimbine | 1994 |
Effects of acute buprenorphine on responses to intranasal cocaine: a pilot study.
Topics: Adult; Affect; Arousal; Buprenorphine; Cocaine; Comorbidity; Double-Blind Method; Drug Administration Schedule; Euphoria; Female; Heroin Dependence; Humans; Male; Pilot Projects; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
A placebo-controlled trial of L-dopa/carbidopa in early cocaine abstinence.
Topics: Adult; Breath Tests; Carbidopa; Cocaine; Drug Combinations; Electrocardiography; Humans; Levodopa; Substance Withdrawal Syndrome | 1993 |
Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients.
Topics: Adult; Amantadine; Cocaine; Dopamine Agonists; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Imipramine treatment of cocaine abuse: possible boundaries of efficacy.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Cocaine; Combined Modality Therapy; Comorbidity; Depressive Disorder; Double-Blind Method; Euphoria; Female; Humans; Imipramine; Male; Middle Aged; Motivation; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome | 1995 |
Carbamazepine and cocaine-cue reactivity.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Arousal; Carbamazepine; Cerebral Cortex; Cocaine; Cues; Double-Blind Method; Electroencephalography; Humans; Male; Middle Aged; Motivation; Signal Processing, Computer-Assisted; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Mazindol treatment for cocaine dependence.
Topics: Adult; Central Nervous System Stimulants; Cocaine; Double-Blind Method; Female; Humans; Male; Mazindol; Neurologic Examination; Substance Abuse Detection; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Effects of methadone or buprenorphine maintenance on the subjective and reinforcing effects of intravenous cocaine in humans.
Topics: Adult; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Methadone; Opioid-Related Disorders; Self Administration; Substance Withdrawal Syndrome; Surveys and Questionnaires | 1996 |
Buprenorphine versus methadone in the treatment of opioid dependence: self-reports, urinalysis, and addiction severity index.
Topics: Adolescent; Adult; Alcoholism; Buprenorphine; Cocaine; Double-Blind Method; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Abuse Detection; Substance Withdrawal Syndrome; Treatment Outcome | 1996 |
P300 assessment of opiate and cocaine users: effects of detoxification and buprenorphine treatment.
Topics: Adult; Arousal; Attention; Brain Mapping; Buprenorphine; Cerebral Cortex; Cocaine; Event-Related Potentials, P300; Heroin Dependence; Humans; Male; Middle Aged; Narcotic Antagonists; Opioid-Related Disorders; Reaction Time; Substance Withdrawal Syndrome | 1996 |
Neurohormonal and behavioral response to methylphenidate in cocaine abstinence.
Topics: Adult; Arousal; Central Nervous System Stimulants; Cocaine; Dopamine; Drug Administration Schedule; Human Growth Hormone; Humans; Male; Methylphenidate; Neurologic Examination; Opioid-Related Disorders; Prolactin; Substance Withdrawal Syndrome | 1996 |
A protocol to switch high-dose, methadone-maintained subjects to buprenorphine.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Buprenorphine; Clonidine; Cocaine; Drug Administration Schedule; Female; Humans; Inpatients; Male; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Oxazepam; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Sympatholytics; Treatment Outcome | 1997 |
Controlled opioid withdrawal evaluation during 72 h dose omission in buprenorphine-maintained patients.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cocaine; Humans; Naloxone; Narcotic Antagonists; Narcotics; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Beneficial effects of thiamine on recognition memory and P300 in abstinent cocaine-dependent patients.
Topics: Adult; Attention; Cerebral Cortex; Cocaine; Double-Blind Method; Electroencephalography; Event-Related Potentials, P300; Female; Humans; Male; Mental Recall; Parietal Lobe; Substance Withdrawal Syndrome; Substance-Related Disorders; Thiamine | 1997 |
Dissociation between subjective and behavioral responses after cocaine stimuli presentations.
Topics: Adult; Arousal; Cocaine; Crack Cocaine; Cues; Female; Humans; Male; Motivation; Personality Inventory; Self Administration; Social Environment; Substance Withdrawal Syndrome; Substance-Related Disorders; Token Economy | 1997 |
Reduced blue cone electroretinogram in withdrawn cocaine dependent patients: a replication.
Topics: Adult; Cocaine; Color; Electroretinography; Humans; Male; Retinal Cone Photoreceptor Cells; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
A laboratory model of cocaine withdrawal in humans: intravenous cocaine.
Topics: Adult; Affect; Blood Pressure; Cocaine; Cues; Depressive Disorder; Heart Rate; Humans; Male; Models, Psychological; Narcotics; Psychiatric Status Rating Scales; Self Administration; Social Environment; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Surveys and Questionnaires | 1997 |
Decreasing striatal 6-FDOPA uptake with increasing duration of cocaine withdrawal.
Topics: Adult; Brain Chemistry; Cocaine; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes; Humans; Male; Narcotics; Neostriatum; Substance Withdrawal Syndrome; Tomography, Emission-Computed | 1997 |
Risperidone diminishes cue-elicited craving in withdrawn cocaine-dependent patients.
Topics: Antipsychotic Agents; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Cues; Drive; Humans; Male; Prospective Studies; Risperidone; Substance Withdrawal Syndrome; Treatment Outcome | 1997 |
Plasma homovanillic acid and the dopamine transporter during cocaine withdrawal.
Topics: Adult; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methoxyhydroxyphenylglycol; Middle Aged; Narcotics; Nerve Tissue Proteins; Substance Withdrawal Syndrome; Tomography, Emission-Computed, Single-Photon | 1998 |
Plasma concentrations of buprenorphine 24 to 72 hours after dosing.
Topics: Administration, Sublingual; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Double-Blind Method; Ethanol; Female; Heroin; Humans; Male; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome; Time Factors | 1999 |
The effects of cocaine on mood and sleep in cocaine-dependent males.
Topics: Administration, Inhalation; Adult; Affect; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Humans; Male; Sleep; Sleep Stages; Substance Withdrawal Syndrome; Surveys and Questionnaires | 1999 |
The combination of phentermine and fenfluramine reduced cocaine withdrawal symptoms in an open trial.
Topics: Adult; Central Nervous System Stimulants; Cocaine; Drug Therapy, Combination; Female; Fenfluramine; Humans; Male; Middle Aged; Narcotics; Phentermine; Pilot Projects; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome; Treatment Outcome | 2000 |
Amantadine in the treatment of cocaine-dependent patients with severe withdrawal symptoms.
Topics: Amantadine; Ambulatory Care; Cocaine; Cocaine-Related Disorders; Dopamine Agents; Double-Blind Method; Female; Humans; Male; Placebos; Severity of Illness Index; Substance Abuse Detection; Substance Withdrawal Syndrome; Treatment Outcome | 2000 |
Effectiveness of propranolol for cocaine dependence treatment may depend on cocaine withdrawal symptom severity.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Humans; Middle Aged; Propranolol; Psychiatric Status Rating Scales; Severity of Illness Index; Substance Withdrawal Syndrome | 2001 |
Cocaine-primed craving and its relationship to depressive symptomatology in individuals with cocaine dependence.
Topics: Adult; Blood Pressure; Cocaine; Cocaine-Related Disorders; Depressive Disorder; Female; Heart Rate; Humans; Male; Psychiatric Status Rating Scales; Regression Analysis; Substance Withdrawal Syndrome | 2002 |
Hypothalamic-pituitary function during alcohol exposure and withdrawal and cocaine exposure.
Topics: Adrenocorticotropic Hormone; Adult; Alcoholic Intoxication; Alcoholism; Cocaine; Dose-Response Relationship, Drug; Double-Blind Method; Ethanol; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Middle Aged; Pituitary-Adrenal System; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Treatment of cocaine dependence in methadone maintenance clients: a pilot study comparing the efficacy of desipramine and amantadine.
Topics: Adolescent; Adult; Amantadine; Baltimore; Cocaine; Desipramine; Female; Follow-Up Studies; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Pilot Projects; Placebos; Research Design; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders; United States | 1992 |
Amantadine may facilitate detoxification of cocaine addicts.
Topics: Adult; Amantadine; Cocaine; Day Care, Medical; Double-Blind Method; Follow-Up Studies; Humans; Male; Middle Aged; Neurologic Examination; Substance Abuse Detection; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Bromocriptine and cocaine cue reactivity in cocaine-dependent patients.
Topics: Adolescent; Adult; Bromocriptine; Cocaine; Depressive Disorder; Humans; Male; Personality Assessment; Placebo Effect; Psychiatric Status Rating Scales; Substance Abuse Detection; Substance Withdrawal Syndrome; Substance-Related Disorders; Videotape Recording | 1992 |
A randomized double-blind study of neuroelectric therapy in opiate and cocaine detoxification.
Topics: Adult; Cocaine; Double-Blind Method; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Opioid-Related Disorders; Substance Abuse Detection; Substance Withdrawal Syndrome; Substance-Related Disorders; Transcutaneous Electric Nerve Stimulation | 1992 |
Pergolide mesylate treatment of cocaine withdrawal.
Topics: Adult; Ambulatory Care; Cocaine; Female; Gastrointestinal Diseases; Hospitalization; Humans; Male; Middle Aged; Pergolide; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
A double-blind amino acids, L-tryptophan and L-tyrosine, and placebo study with cocaine-dependent subjects in an inpatient chemical dependency treatment center.
Topics: Adolescent; Adult; Cocaine; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; MMPI; Substance Withdrawal Syndrome; Substance-Related Disorders; Tryptophan; Tyrosine | 1990 |
Bromocriptine treatment of cocaine withdrawal symptoms.
Topics: Acute Disease; Adult; Bromocriptine; Clinical Trials as Topic; Cocaine; Humans; Male; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Bromocriptine and amantadine in cocaine detoxification.
Topics: Adult; Amantadine; Brain; Bromocriptine; Clinical Trials as Topic; Cocaine; Humans; Male; Random Allocation; Receptors, Dopamine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Bromocriptine as treatment of cocaine abuse.
Topics: Adolescent; Adult; Bromocriptine; Cocaine; Female; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1985 |
Sphenopalatine ganglion blocks for the treatment of nicotine addiction.
Topics: Anesthesia, Local; Bupivacaine; Clinical Trials as Topic; Cocaine; Double-Blind Method; Female; Ganglia, Parasympathetic; Ganglionic Blockers; Humans; Male; Middle Aged; Palate; Substance Withdrawal Syndrome; Tobacco Use Disorder | 1988 |
Bromocriptine in cocaine withdrawal--does it work?
Topics: Adolescent; Adult; Bromocriptine; Clinical Trials as Topic; Cocaine; Female; Humans; Male; Prolactin; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
A pilot trial of amantadine for ambulatory withdrawal for cocaine dependence.
Topics: Adult; Amantadine; Bromocriptine; Clinical Trials as Topic; Cocaine; Double-Blind Method; Humans; Patient Compliance; Substance Withdrawal Syndrome | 1988 |
Bromocriptine therapy in cocaine withdrawal.
Topics: Adult; Bromocriptine; Clinical Trials as Topic; Cocaine; Double-Blind Method; Humans; Male; Psychiatric Status Rating Scales; Random Allocation; Substance Withdrawal Syndrome | 1987 |
Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse.
Topics: Adult; Cocaine; Desipramine; Double-Blind Method; Humans; Male; Phencyclidine; Psychotherapy, Brief; Substance Withdrawal Syndrome | 1987 |
Treatment of depression in chronic cocaine and phencyclidine abuse with desipramine.
Topics: Adult; Clinical Trials as Topic; Cocaine; Depression; Desipramine; Humans; Male; Phencyclidine; Placebos; Substance Withdrawal Syndrome; Substance-Related Disorders | 1986 |
Double-blind comparison of amantadine and bromocriptine for ambulatory withdrawal from cocaine dependence.
Topics: Adolescent; Adult; Amantadine; Ambulatory Care; Bromocriptine; Clinical Trials as Topic; Cocaine; Double-Blind Method; Humans; Patient Compliance; Substance Withdrawal Syndrome | 1987 |
Studies of the dependence-producing potential of the narcotic antagonist 2-cyclopropylmethyl-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan (cyclazocine, WIN-20,740, ARC II-c-3).
Topics: Amphetamine; Analgesics; Barbiturates; Cannabis; Clinical Trials as Topic; Cocaine; Cyclazocine; Drug Tolerance; Euphoria; Humans; Morphine; Nalorphine; Narcotic Antagonists; Pupil; Substance Withdrawal Syndrome; Substance-Related Disorders | 1965 |
An acute dose of nicotine enhances cue-induced cocaine craving.
Topics: Adult; Analysis of Variance; Anxiety; Behavior, Addictive; Cocaine-Related Disorders; Conditioning, Psychological; Crack Cocaine; Cross-Over Studies; Cues; Double-Blind Method; Drive; Female; Galvanic Skin Response; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Skin Temperature; Substance Withdrawal Syndrome; Tobacco Use Disorder | 1998 |
694 other study(ies) available for cocaine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Withdrawal from cocaine conditioning progressively alters AMPA receptor-mediated transmission in the ventral hippocampus.
Topics: Animals; Cocaine; Excitatory Postsynaptic Potentials; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Receptors, AMPA; Substance Withdrawal Syndrome; Time Factors | 2022 |
Rapid Eye Movement Sleep Engages Melanin-Concentrating Hormone Neurons to Reduce Cocaine Seeking.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Male; Neurons; Nucleus Accumbens; Rats; Recurrence; Self Administration; Sleep; Sleep, REM; Substance Withdrawal Syndrome | 2022 |
GluA2-lacking AMPA receptors in the nucleus accumbens core and shell contribute to the incubation of oxycodone craving in male rats.
Topics: Animals; Cocaine; Craving; Male; Nucleus Accumbens; Oxycodone; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Self Administration; Substance Withdrawal Syndrome | 2022 |
Serum BDNF levels increase during early drug withdrawal in alcohol and crack cocaine addiction.
Topics: Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Crack Cocaine; Ethanol; Follow-Up Studies; Humans; Male; Substance Withdrawal Syndrome | 2023 |
Membrane excitability of nucleus accumbens neurons gates the incubation of cocaine craving.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Craving; Humans; Mice; Neurons; Nucleus Accumbens; Rats; Receptors, Dopamine; Substance Withdrawal Syndrome | 2023 |
Ubiquitin-proteasomal regulation of chromatin remodeler INO80 in the nucleus accumbens mediates persistent cocaine craving.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Chromatin; Cocaine; Disease Models, Animal; Drug-Seeking Behavior; Early Growth Response Protein 1; Humans; Male; Nucleus Accumbens; Promoter Regions, Genetic; Protein Binding; Protein Subunits; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Ubiquitin-Protein Ligases | 2019 |
Cocaine and chronic stress exposure produce an additive increase in neuronal activity in the basolateral amygdala.
Topics: Animals; Basolateral Nuclear Complex; Cocaine; Cocaine-Related Disorders; Craving; Cues; Drug-Seeking Behavior; Male; Neurons; Nucleus Accumbens; Rats; Self Administration; Stress, Psychological; Substance Withdrawal Syndrome | 2021 |
Cocaine Dysregulates Dynorphin Modulation of Inhibitory Neurotransmission in the Ventral Pallidum in a Cell-Type-Specific Manner.
Topics: Animals; Basal Forebrain; Cocaine; Drug-Seeking Behavior; Dynorphins; Female; Male; Mice; Mice, Inbred C57BL; Neurons; Reward; Substance Withdrawal Syndrome; Synaptic Transmission | 2020 |
Effects of Kappa opioid receptor blockade by LY2444296 HCl, a selective short-acting antagonist, during chronic extended access cocaine self-administration and re-exposure in rat.
Topics: Animals; Behavior, Addictive; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Uptake Inhibitors; Male; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Administration; Substance Withdrawal Syndrome | 2020 |
History of withdrawal modulates drug- and food-cue reactivity in cocaine dependent participants.
Topics: Adult; Behavior, Addictive; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Female; Food; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Reward; Substance Withdrawal Syndrome; Young Adult | 2020 |
Intermittent access cocaine self-administration produces psychomotor sensitization: effects of withdrawal, sex and cross-sensitization.
Topics: Administration, Intravenous; Animals; Behavior, Addictive; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Male; Motivation; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Self Administration; Sex Factors; Substance Withdrawal Syndrome | 2020 |
Cocaine Self-Administration and Abstinence Modulate NMDA Receptor Subunits and Active Zone Proteins in the Rat Nucleus Accumbens.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Drug-Seeking Behavior; GTP-Binding Proteins; Male; Nerve Tissue Proteins; Neuronal Plasticity; Nucleus Accumbens; Protein Subunits; rab3A GTP-Binding Protein; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Self Administration; Substance Withdrawal Syndrome; Synaptic Transmission; Up-Regulation | 2020 |
Combined cocaine and clonazepam administration induces REM sleep loss and anxiety-like withdrawal behaviors in rats.
Topics: Animals; Anxiety; Behavior, Animal; Clonazepam; Cocaine; Corticosterone; Exploratory Behavior; Male; Open Field Test; Rats; Rats, Wistar; Sleep, REM; Substance Withdrawal Syndrome | 2020 |
Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving.
Topics: Adult; Anxiety; Cocaine; Cocaine-Related Disorders; Craving; Cues; Female; Humans; Magnetic Resonance Imaging; Male; Periaqueductal Gray; Prefrontal Cortex; Reward; Substance Withdrawal Syndrome; Young Adult | 2020 |
Cannabidiol Modulates Behavioural and Gene Expression Alterations Induced by Spontaneous Cocaine Withdrawal.
Topics: Animals; Anxiety; Cannabidiol; Cocaine; Dopamine Plasma Membrane Transport Proteins; Gene Expression; Male; Mice; Motor Activity; Nucleus Accumbens; Real-Time Polymerase Chain Reaction; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2021 |
Time-dependent regulation of perineuronal nets in the cerebellar cortex during abstinence of cocaine-self administration.
Topics: Animals; Cerebellar Cortex; Cocaine; Cocaine-Related Disorders; Interneurons; Male; Nerve Net; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 2021 |
Potentiated Response of ERK/MAPK Signaling is Associated with Prolonged Withdrawal from Cocaine Behavioral Sensitization.
Topics: Animals; Behavior, Animal; Cocaine; Excitatory Amino Acid Antagonists; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Nucleus Accumbens; Piperidines; Protein Kinase Inhibitors; Rats; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2021 |
Chronic opipramol treatment extinguishes cocaine craving through Rac1 in responders: A rat model study.
Topics: Animals; Antidepressive Agents, Tricyclic; Cocaine; Cocaine-Related Disorders; Craving; Cues; Disease Models, Animal; Drug-Seeking Behavior; Extinction, Psychological; Male; Neurons; Nucleus Accumbens; Opipramol; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 2021 |
Females develop features of an addiction-like phenotype sooner during withdrawal than males.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Uptake Inhibitors; Female; Male; Motivation; Phenotype; Rats; Rats, Sprague-Dawley; Self Administration; Sex Characteristics; Substance Withdrawal Syndrome | 2021 |
Cannabidiol prevents several of the behavioral alterations related to cocaine addiction in mice.
Topics: Animals; Cannabidiol; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Dose-Response Relationship, Drug; Extinction, Psychological; Hyperkinesis; Injections, Intraperitoneal; Locomotion; Male; Mice; Mice, Inbred C57BL; Substance Withdrawal Syndrome | 2021 |
Preclinical evidence to support repurposing everolimus for craving reduction during protracted drug withdrawal.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Craving; Cues; Drug Repositioning; Drug-Seeking Behavior; Everolimus; Extinction, Psychological; Pharmaceutical Preparations; Phosphatidylinositol 3-Kinases; Rats; Self Administration; Substance Withdrawal Syndrome | 2021 |
Mirtazapine-induced decrease in cocaine sensitization is enhanced by environmental enrichment in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Environment; Housing, Animal; Locomotion; Male; Mirtazapine; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2021 |
CRFR1 in the ventromedial caudate putamen modulates acute stress-enhanced expression of cocaine locomotor sensitization.
Topics: Analysis of Variance; Anesthetics, Local; Aniline Compounds; Animals; Cocaine; Gene Expression Regulation; Male; Motor Activity; Putamen; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Stress, Psychological; Substance Withdrawal Syndrome; Swimming; Time Factors | 2017 |
Effects of repeated cocaine exposure and withdrawal on voluntary ethanol drinking, and the expression of glial glutamate transporters in mesocorticolimbic system of P rats.
Topics: Alcohol Drinking; Amino Acid Transport System X-AG; Animals; Cocaine; Ethanol; Glutamic Acid; Male; Neuroglia; Nucleus Accumbens; Prefrontal Cortex; Rats; Substance Withdrawal Syndrome | 2017 |
Abstinence environment contributes to age differences in reinstatement of cocaine seeking between adolescent and adult male rats.
Topics: Age Factors; Animals; Behavior, Animal; Cocaine; Cues; Male; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome | 2017 |
Adolescent Exposure to the Synthetic Cannabinoid WIN 55212-2 Modifies Cocaine Withdrawal Symptoms in Adult Mice.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Exploratory Behavior; Hindlimb Suspension; Male; Memory; Mice; Morpholines; Naphthalenes; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome | 2017 |
Reduced interhemispheric executive control network coupling in men during early cocaine abstinence: A pilot study.
Topics: Cocaine; Cocaine-Related Disorders; Executive Function; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways; Pilot Projects; Recurrence; Substance Withdrawal Syndrome; Time Factors | 2017 |
Repeated cocaine exposure dysregulates BDNF expression and signaling in the mesocorticolimbic pathway of the adolescent rat.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Male; Nucleus Accumbens; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Signal Transduction; Substance Withdrawal Syndrome | 2019 |
Withdrawal From Cocaine Self-administration Alters the Regulation of Protein Translation in the Nucleus Accumbens.
Topics: Animals; Cocaine; Craving; Drug-Seeking Behavior; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Self Administration; Substance Withdrawal Syndrome | 2018 |
Drug-induced dysphoria is enhanced following prolonged cocaine abstinence and dynamically tracked by nucleus accumbens neurons.
Topics: Affect; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Electrophysiological Phenomena; Extinction, Psychological; Male; Neurons; Nucleus Accumbens; Rats; Saccharin; Self Administration; Substance Withdrawal Syndrome; Sweetening Agents | 2019 |
c-Fos marking of identified midbrain neurons coactive after nicotine administration in-vivo.
Topics: Animals; Autonomic Nervous System; Cocaine; Dopamine Uptake Inhibitors; Dopaminergic Neurons; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Reward; Substance Withdrawal Syndrome; Transcriptional Activation; Ventral Tegmental Area | 2018 |
Cocaine-induced epigenetic DNA modification in mouse addiction-specific and non-specific tissues.
Topics: Animals; Blood Cells; Cerebellum; Cocaine; Cocaine-Related Disorders; DNA Modification Methylases; Dopamine Uptake Inhibitors; Epigenesis, Genetic; Gene Expression Regulation; Male; Mice, Inbred C57BL; Motor Activity; Nucleus Accumbens; RNA, Messenger; Substance Withdrawal Syndrome | 2018 |
Drug Refraining and Seeking Potentiate Synapses on Distinct Populations of Accumbens Medium Spiny Neurons.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Dopaminergic Neurons; Drug-Seeking Behavior; Excitatory Postsynaptic Potentials; Extinction, Psychological; Genes, Reporter; Male; Mice; Mice, Transgenic; Nucleus Accumbens; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Self Administration; Substance Withdrawal Syndrome; Synapses | 2018 |
From Traumatic Childhood to Cocaine Abuse: The Critical Function of the Immune System.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Dopaminergic Neurons; Drug-Seeking Behavior; Female; Humans; Immune System; Male; Mice; Mice, Inbred DBA; Patch-Clamp Techniques; Self Administration; Social Environment; Stress, Psychological; Substance Withdrawal Syndrome; Synaptic Transmission; Ventral Tegmental Area | 2018 |
Dnmt3a2 in the Nucleus Accumbens Shell Is Required for Reinstatement of Cocaine Seeking.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Craving; Cues; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Enzyme Induction; Extinction, Psychological; Genes, Immediate-Early; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Nucleus Accumbens; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; RNA Interference; Self Administration; Substance Withdrawal Syndrome | 2018 |
Cocaine withdrawal reduces GABA
Topics: Animals; Behavior, Animal; Cocaine; Entopeduncular Nucleus; Habenula; Male; Mice, Inbred C57BL; Neurons; Receptors, GABA-B; Substance Withdrawal Syndrome; Synaptic Transmission | 2019 |
The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory.
Topics: Animals; Benzazepines; Cocaine; Conditioning, Psychological; Enzyme Inhibitors; Extinction, Psychological; Jumonji Domain-Containing Histone Demethylases; Male; Memory; Memory Consolidation; Mice; Prefrontal Cortex; Pyrimidines; Receptors, N-Methyl-D-Aspartate; Reward; Substance Withdrawal Syndrome | 2018 |
Comparison of the effects of abstinence on MDMA and cocaine self-administration in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Addictive; Cocaine; Dopamine Uptake Inhibitors; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Self Administration; Serotonin; Substance Withdrawal Syndrome | 2018 |
Expectations about alcohol, cocaine, and benzodiazepine abstinence following inpatient heroin withdrawal management.
Topics: Adult; Alcohol Drinking; Benzodiazepines; Cocaine; Female; Humans; Inpatients; Male; Motivation; Opioid-Related Disorders; Prevalence; Self Medication; Substance Withdrawal Syndrome; Substance-Related Disorders; Surveys and Questionnaires; Young Adult | 2019 |
Making risky decisions to take drug: Effects of cocaine abstinence in cocaine users.
Topics: Adult; Black People; Boredom; Candy; Cocaine; Cocaine Smoking; Cocaine-Related Disorders; Decision Making; Humans; Inpatients; Male; Middle Aged; Motivation; Risk-Taking; Substance Withdrawal Syndrome | 2019 |
The Stimulant Selective Severity Assessment: A replication and exploratory extension of the Cocaine Selective Severity Assessment.
Topics: Adult; Central Nervous System Stimulants; Cocaine; Craving; Female; Humans; Male; Methamphetamine; Middle Aged; Severity of Illness Index; Substance Withdrawal Syndrome; Young Adult | 2019 |
The role of DNA methyltransferase activity in cocaine treatment and withdrawal in the nucleus accumbens of mice.
Topics: Animals; Cocaine; Disease Models, Animal; DNA Methylation; Dopamine Uptake Inhibitors; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Substance Withdrawal Syndrome | 2020 |
Mirtazapine attenuates anxiety- and depression-like behaviors in rats during cocaine withdrawal.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Cocaine; Depression; Disease Models, Animal; Dopamine Uptake Inhibitors; Male; Mirtazapine; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2019 |
Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation Mediate Structural and Behavioral Adaptations During Withdrawal From Cocaine Self-Administration.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Female; Locomotion; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Microtubules; Oncogene Protein pp60(v-src); Phosphorylation; Rats; Self Administration; Substance Withdrawal Syndrome; Synapses | 2019 |
Hippocampal BDNF regulates a shift from flexible, goal-directed to habit memory system function following cocaine abstinence.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Goals; Habits; Hippocampus; Male; Maze Learning; Memory; Rats; Rats, Long-Evans; Self Administration; Substance Withdrawal Syndrome | 2019 |
LC/MS/MS evaluation of cocaine and its metabolites in different brain areas, peripheral organs and plasma in cocaine self-administering rats.
Topics: Animals; Biotransformation; Brain; Central Nervous System Stimulants; Chromatography, Liquid; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Half-Life; Injections, Intravenous; Kidney; Liver; Male; Metabolic Clearance Rate; Myocardium; Rats; Rats, Wistar; Reproducibility of Results; Self Administration; Substance Withdrawal Syndrome; Tandem Mass Spectrometry; Tissue Distribution | 2012 |
[Sleep disturbance induced by cocaine abstinence involving in A2A receptor over-expression in rat hypothalamus].
Topics: Animals; Cocaine; Dyssomnias; Electroencephalography; Hypothalamus; Male; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Substance Withdrawal Syndrome | 2012 |
The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice.
Topics: Animals; Anisoles; Behavior, Animal; Cocaine; Conditioning, Psychological; Cyclohexanols; Dose-Response Relationship, Drug; Female; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Receptor, Cannabinoid, CB2; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2013 |
Cocaine-induced membrane adaptation in the central nucleus of amygdala.
Topics: Amygdala; Animals; Cocaine; Corticotropin-Releasing Hormone; Male; Membrane Potentials; Neurons; Rats; Self Administration; Substance Withdrawal Syndrome | 2013 |
Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization.
Topics: Animals; Cocaine; Dendritic Spines; Gene Knockdown Techniques; Guanine Nucleotide Exchange Factors; Male; Motor Activity; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Self Administration; Substance Withdrawal Syndrome; Up-Regulation | 2013 |
Short-term abstinence from cocaine self-administration, but not passive cocaine infusion, elevates αCaMKII autophosphorylation in the rat nucleus accumbens and medial prefrontal cortex.
Topics: Animals; Behavior, Addictive; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cocaine; Infusions, Intravenous; Male; Nucleus Accumbens; Phosphorylation; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2014 |
A variant on the kappa opioid receptor gene (OPRK1) is associated with stress response and related drug craving, limbic brain activation and cocaine relapse risk.
Topics: Adult; Amygdala; Black or African American; Brain; Cerebellum; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Female; Functional Neuroimaging; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Hypothalamus; Limbic System; Magnetic Resonance Imaging; Male; Mesencephalon; Middle Aged; Pituitary-Adrenal System; Receptors, Opioid, kappa; Recurrence; Stress, Psychological; Substance Withdrawal Syndrome; Thalamus | 2013 |
Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving.
Topics: Amygdala; Animals; Channelrhodopsins; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation; HEK293 Cells; Humans; Male; Neural Pathways; Nucleus Accumbens; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Self Administration; Spermine; Substance Withdrawal Syndrome; Synapses | 2013 |
Different locomotor sensitization responses to repeated cocaine injections are associated with differential phosphorylation of GluA1 in the dorsomedial striatum of adult rats.
Topics: Age Factors; Animals; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Drug Administration Schedule; Male; Motor Activity; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Serine; Substance Withdrawal Syndrome; Time Factors | 2013 |
Withdrawal from extended-access cocaine self-administration results in dysregulated functional activity and altered locomotor activity in rats.
Topics: Animals; Attention; Brain; Cocaine; Cocaine-Related Disorders; Glucose; Learning; Locomotion; Male; Memory; Rats; Rats, Sprague-Dawley; Reward; Self Administration; Sleep; Substance Withdrawal Syndrome | 2013 |
Pharmacological evidence for an abstinence-induced switch in 5-HT1B receptor modulation of cocaine self-administration and cocaine-seeking behavior.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Male; Piperidones; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Reinforcement Schedule; Self Administration; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Spiro Compounds; Substance Withdrawal Syndrome; Time Factors | 2014 |
Time-dependent changes in nicotine behavioral responsivity during early withdrawal from chronic cocaine administration and attenuation of cocaine sensitization by mecamylamine.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2014 |
Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum.
Topics: Analgesics, Opioid; Animals; Cocaine; gamma-Aminobutyric Acid; Globus Pallidus; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Self Administration; Substance Withdrawal Syndrome; Synaptic Transmission | 2014 |
Interactions between N-ethylmaleimide-sensitive factor and GluR2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine.
Topics: Amino Acid Sequence; Animals; Cocaine; Male; Microinjections; Molecular Sequence Data; Motor Activity; N-Ethylmaleimide-Sensitive Proteins; Nucleus Accumbens; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Substance Withdrawal Syndrome | 2014 |
CRF₂ receptor-deficiency reduces recognition memory deficits and vulnerability to stress induced by cocaine withdrawal.
Topics: Animals; Brain; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Gene Expression; Male; Memory Disorders; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins c-fos; Receptors, Corticotropin-Releasing Hormone; Recognition, Psychology; Resilience, Psychological; Stress, Psychological; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase | 2014 |
The effect of active and passive intravenous cocaine administration on the extracellular signal-regulated kinase (ERK) activity in the rat brain.
Topics: Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Extinction, Psychological; Extracellular Signal-Regulated MAP Kinases; Injections, Intravenous; Male; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome | 2014 |
Functional consequences of cocaine re-exposure after discontinuation of cocaine availability.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Cocaine; Cocaine-Related Disorders; Deoxyglucose; Dopamine Uptake Inhibitors; Food; Glucose; Macaca mulatta; Male; Random Allocation; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2014 |
GluN2B-containing NMDA receptors blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dietary Sucrose; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Excitatory Postsynaptic Potentials; Male; Neuronal Plasticity; Patch-Clamp Techniques; Random Allocation; Rats, Long-Evans; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Self Administration; Septal Nuclei; Substance Withdrawal Syndrome; Synapses; Tissue Culture Techniques | 2015 |
Functional connectivity in frontal-striatal brain networks and cocaine self-administration in female rhesus monkeys.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Female; Macaca mulatta; Magnetic Resonance Imaging; Neural Pathways; Prefrontal Cortex; Self Administration; Sex Factors; Substance Withdrawal Syndrome | 2015 |
Brief intermittent cocaine self-administration and abstinence sensitizes cocaine effects on the dopamine transporter and increases drug seeking.
Topics: Animals; Central Nervous System Sensitization; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Drug-Seeking Behavior; Male; Nucleus Accumbens; Rats; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome | 2015 |
Long-term cannabis abuse and early-onset cannabis use increase the severity of cocaine withdrawal during detoxification and rehospitalization rates due to cocaine dependence.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Female; Follow-Up Studies; Humans; Marijuana Abuse; Mental Health Services; Patient Readmission; Severity of Illness Index; Substance Withdrawal Syndrome; Time Factors; Young Adult | 2014 |
Cocaine Withdrawal Impairs mGluR5-Dependent Long-Term Depression in Nucleus Accumbens Shell Neurons of Both Direct and Indirect Pathways.
Topics: Animals; Benzamides; Chromones; Cocaine; Cocaine-Related Disorders; Dopaminergic Neurons; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Genes, Reporter; Glycine; Imidazoles; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Nucleus Accumbens; Pyrazoles; Pyridazines; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D1; Receptors, Dopamine D2; Resorcinols; Substance Withdrawal Syndrome | 2015 |
Withdrawal from cocaine self-administration and yoked cocaine delivery dysregulates glutamatergic mGlu5 and NMDA receptors in the rat brain.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Extinction, Psychological; Homer Scaffolding Proteins; Male; Protein Subunits; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Self Administration; Substance Withdrawal Syndrome | 2015 |
Cocaine-induced suppression of saccharin intake and morphine modulation of Ca²⁺ channel currents in sensory neurons of OPRM1 A118G mice.
Topics: Animals; Behavior, Addictive; Calcium Channels; Cells, Cultured; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Eating; Humans; Male; Mice, Transgenic; Polymorphism, Single Nucleotide; Receptors, Opioid, mu; Reward; Saccharin; Sensory Receptor Cells; Substance Withdrawal Syndrome; Trigeminal Ganglion | 2015 |
Stereochemistry and neuropharmacology of a 'bath salt' cathinone: S-enantiomer of mephedrone reduces cocaine-induced reward and withdrawal in invertebrates.
Topics: Animals; Cocaine; Conditioning, Psychological; Methamphetamine; Movement; Planarians; Reward; Stereotyped Behavior; Substance Withdrawal Syndrome | 2015 |
A single brain-derived neurotrophic factor infusion into the dorsomedial prefrontal cortex attenuates cocaine self-administration-induced phosphorylation of synapsin in the nucleus accumbens during early withdrawal.
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Agents; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Male; Nucleus Accumbens; Phosphorylation; Prefrontal Cortex; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Synapsins | 2014 |
Temporal regulation of peripheral BDNF levels during cocaine and morphine withdrawal: comparison with a natural reward.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cocaine; Dopamine Uptake Inhibitors; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Rats; Rats, Sprague-Dawley; Reward; Substance Withdrawal Syndrome | 2014 |
Increased excitability of lateral habenula neurons in adolescent rats following cocaine self-administration.
Topics: Action Potentials; Age Factors; Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Electric Impedance; Habenula; In Vitro Techniques; Male; Neurons; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2014 |
Changes in brain-derived neurotrophic factor (BDNF) during abstinence could be associated with relapse in cocaine-dependent patients.
Topics: Adolescent; Adult; Brain-Derived Neurotrophic Factor; Chronic Disease; Cocaine; Cocaine-Related Disorders; Depression; Drug-Seeking Behavior; Female; Humans; Male; Middle Aged; Recurrence; Substance Withdrawal Syndrome; Young Adult | 2015 |
Persistent increases in rat hypothalamic POMC gene expression following chronic withdrawal from chronic "binge" pattern escalating-dose, but not steady-dose, cocaine.
Topics: Amygdala; Animals; Body Weight; Cocaine; Cocaine-Related Disorders; Corticosterone; Dopamine Uptake Inhibitors; Hypothalamus; Male; Naloxone; Narcotic Antagonists; Pro-Opiomelanocortin; Rats, Inbred F344; Reinforcement Schedule; RNA, Messenger; Substance Withdrawal Syndrome | 2015 |
Dorsal raphe 5-HT(2C) receptor and GABA networks regulate anxiety produced by cocaine withdrawal.
Topics: Action Potentials; Animals; Anxiety; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dorsal Raphe Nucleus; Exploratory Behavior; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Receptor, Serotonin, 5-HT2C; Serotonin Agents; Substance Withdrawal Syndrome; Time Factors; Tryptophan Hydroxylase | 2015 |
Persistent conditioned place preference to cocaine and withdrawal hypo-locomotion to mephedrone in the flatworm planaria.
Topics: Animals; Cocaine; Conditioning, Psychological; Disease Models, Animal; Locomotion; Methamphetamine; Planarians; Psychotropic Drugs; Substance Withdrawal Syndrome; Substance-Related Disorders | 2015 |
Short-term withdrawal from developmental exposure to cocaine activates the glucocorticoid receptor and alters spine dynamics.
Topics: Animals; Cocaine; Corticosterone; Dendritic Spines; Disease Models, Animal; Dopamine Uptake Inhibitors; Male; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, Glucocorticoid; RNA, Messenger; Substance Withdrawal Syndrome; Tacrolimus Binding Proteins; Time Factors | 2015 |
Response of the Ubiquitin-Proteasome System to Memory Retrieval After Extended-Access Cocaine or Saline Self-Administration.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Craving; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Male; Memory; Nucleus Accumbens; Proteasome Endopeptidase Complex; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Ubiquitin | 2015 |
[Hell after the pleasure: drug-induced negative symptoms involve lateral habenula].
Topics: Animals; Anxiety; Avoidance Learning; Brain Mapping; Cocaine; Cocaine-Related Disorders; Depression; Dopaminergic Neurons; Efferent Pathways; Habenula; Humans; Models, Neurological; Motor Activity; Neuronal Plasticity; Pleasure; Protein Transport; Rats; Receptors, AMPA; Receptors, Dopamine; Reward; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2015 |
Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens.
Topics: Animals; Cocaine; Dendritic Spines; Dominance-Subordination; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Green Fluorescent Proteins; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Nucleus Accumbens; Patch-Clamp Techniques; Receptors, Dopamine D1; Receptors, Dopamine D2; Stress, Psychological; Substance Withdrawal Syndrome; Synaptic Transmission; Tissue Culture Techniques | 2016 |
Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cocaine; GABAergic Neurons; K Cl- Cotransporters; Male; Mice; Mice, Inbred C57BL; Microglia; Models, Neurological; Morphine; Neuroimmunomodulation; Reward; Substance Withdrawal Syndrome; Symporters; Ventral Thalamic Nuclei | 2016 |
Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope.
Topics: Animals; Behavior, Animal; Chromatin Assembly and Disassembly; Cocaine; DNA-Binding Proteins; Gene Knockdown Techniques; Histone Deacetylase 1; Histone Deacetylase 2; Lamin Type A; Membrane Proteins; Mice; Monoamine Oxidase; Nuclear Envelope; Nuclear Proteins; Nucleus Accumbens; Promoter Regions, Genetic; Protein Binding; Protein Transport; Rats; Receptors, sigma; Sigma-1 Receptor; Sp3 Transcription Factor; Substance Withdrawal Syndrome; Transcription, Genetic | 2015 |
Relationship between central behavioral effects and peripheral sympathetic neurotransmission functionality during acute cocaine withdrawal syndrome in adult rats.
Topics: Animals; Calcium Channels, L-Type; Catecholamines; Cocaine; Imidazoline Receptors; Male; Maze Learning; Motor Activity; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Substance Withdrawal Syndrome; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens | 2016 |
Cocaine craving during protracted withdrawal requires PKCε priming within vmPFC.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Craving; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Immunoblotting; Male; Prefrontal Cortex; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2017 |
Resveratrol fails to affect cocaine conditioned place preference behavior, but alleviates anxiety-like behaviors in cocaine withdrawn rats.
Topics: Animals; Anxiety; Behavior, Animal; Cocaine; Conditioning, Operant; Cytokines; Hippocampus; Male; Motor Activity; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Substance Withdrawal Syndrome | 2016 |
Abstinence from cocaine-self-administration activates the nELAV/GAP -43 pathway in the hippocampus: A stress-related effect?
Topics: Animals; Blotting, Western; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; ELAV-Like Protein 1; GAP-43 Protein; Hippocampus; Rats; Self Administration; Signal Transduction; Stress, Psychological; Substance Withdrawal Syndrome | 2016 |
Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2CR) system.
Topics: Animals; Attention; Azepines; Cell Membrane; Cocaine; Cocaine-Related Disorders; Cohort Studies; Conditioning, Operant; Cues; Cytoplasm; Dietary Sucrose; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Indoles; Male; Prefrontal Cortex; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; RNA, Messenger; Self Administration; Serotonin 5-HT2 Receptor Agonists; Substance Withdrawal Syndrome; Time Factors | 2016 |
Large-Scale, Ion-Current-Based Proteomic Investigation of the Rat Striatal Proteome in a Model of Short- and Long-Term Cocaine Withdrawal.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Neuronal Plasticity; Proteome; Proteomics; Rats; Substance Withdrawal Syndrome; Time Factors | 2016 |
Benzodiazepine inhibits anxiogenic-like response in cocaine or ethanol withdrawn planarians.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Clorazepate Dipotassium; Cocaine; Darkness; Dose-Response Relationship, Drug; Ethanol; Light; Planarians; Substance Withdrawal Syndrome; Time Factors | 2016 |
Re-silencing of silent synapses unmasks anti-relapse effects of environmental enrichment.
Topics: Amygdala; Animals; Behavior Therapy; Cocaine; Cocaine-Related Disorders; Male; Neural Inhibition; Neural Pathways; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Recurrence; Substance Withdrawal Syndrome; Synapses; Treatment Outcome | 2016 |
Neuronal metabolomics by ion mobility mass spectrometry in cocaine self-administering rats after early and late withdrawal.
Topics: Adenosine; Animals; Cocaine; Corpus Striatum; Creatine; Glutathione; Humans; Male; Mass Spectrometry; Metabolomics; Neurons; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Time Factors | 2016 |
Altered activity-based sleep measures in rhesus monkeys following cocaine self-administration and abstinence.
Topics: Actigraphy; Animals; Cocaine; Cocaine-Related Disorders; Cognition; Cognition Disorders; Macaca mulatta; Male; Self Administration; Sleep Wake Disorders; Sleep, REM; Substance Withdrawal Syndrome | 2016 |
Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol.
Topics: Alcohol Abstinence; Amygdala; Analgesics, Opioid; Animals; Anxiety; Behavior, Animal; Brain; Cannabinoid Receptor Agonists; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Dronabinol; Drug-Seeking Behavior; Emotions; Ethanol; Male; Mice; Morphine; Motivation; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Social Behavior; Stereotyped Behavior; Substance Withdrawal Syndrome | 2017 |
Cocaine withdrawal alters the reward omission effect and enhances traits of negative urgency in rats across multiple days of testing.
Topics: Animals; Behavior, Addictive; Cocaine; Conditioning, Operant; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Rats; Rats, Sprague-Dawley; Reward; Substance Withdrawal Syndrome | 2016 |
Cocaine abstinence induces emotional impairment and brain region-specific upregulation of the oxytocin receptor binding.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Corticosterone; Emotions; Hypothalamo-Hypophyseal System; Male; Mice; Pituitary-Adrenal System; Protein Binding; Receptors, Oxytocin; Substance Withdrawal Syndrome; Up-Regulation | 2016 |
Incubation of Cue-Induced Craving in Adults Addicted to Cocaine Measured by Electroencephalography.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Comorbidity; Craving; Cross-Sectional Studies; Cues; Electroencephalography; Evoked Potentials; Follow-Up Studies; Humans; Pattern Recognition, Visual; Risk Factors; Self Report; Substance Withdrawal Syndrome; Translational Research, Biomedical | 2016 |
White matter disruptions in male cocaine polysubstance users: Associations with severity of drug use and duration of abstinence.
Topics: Adult; Anisotropy; Case-Control Studies; Cocaine; Cocaine-Related Disorders; Corpus Callosum; Diffusion Tensor Imaging; Gyrus Cinguli; Humans; Male; Substance Withdrawal Syndrome; White Matter; Young Adult | 2016 |
Long-Lasting Impairment of mGluR5-Activated Intracellular Pathways in the Striatum After Withdrawal of Cocaine Self-Administration.
Topics: Acute Disease; Animals; Chronic Disease; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disease Models, Animal; Dopamine Uptake Inhibitors; Excitatory Amino Acid Agents; Male; MAP Kinase Signaling System; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Self Administration; Substance Withdrawal Syndrome; Tissue Culture Techniques | 2017 |
Cocaine Withdrawal Reduces Gamma-Aminobutyric Acid-Ergic Transmission and Gephyrin Expression at Medial Prefrontal Cortex in Cocaine-Conditioned Place-Preference Rats, Which Shows Increased Cocaine Seeking.
Topics: Animals; Carrier Proteins; Cocaine; Conditioning, Psychological; Drug-Seeking Behavior; Excitatory Postsynaptic Potentials; GABAergic Neurons; Inhibitory Postsynaptic Potentials; Male; Membrane Proteins; Prefrontal Cortex; Rats; Substance Withdrawal Syndrome | 2017 |
Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference.
Topics: Animals; Calcium; Cocaine; Disks Large Homolog 4 Protein; Guanylate Kinases; Membrane Proteins; Mice, Knockout; Nucleus Accumbens; Receptors, AMPA; Receptors, Glutamate; Substance Withdrawal Syndrome; Synapses | 2017 |
Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis.
Topics: Adaptation, Physiological; Aging; Animals; Behavior, Animal; Cocaine; Cognition Disorders; Dentate Gyrus; Emotions; Exploratory Behavior; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Male; Memory Disorders; Mice, Inbred C57BL; Neurogenesis; Proto-Oncogene Proteins c-fos; Substance Withdrawal Syndrome | 2017 |
In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Local; Animals; Benzamides; Bridged Bicyclo Compounds; Cocaine; Conditioning, Operant; Disease Models, Animal; Fenofibrate; Hypolipidemic Agents; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Oxazoles; PPAR alpha; Pyrimidines; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tyrosine | 2017 |
Adolescent but not adult ethanol binge drinking modulates cocaine withdrawal symptoms in mice.
Topics: Age Factors; Alcohol Drinking; Animals; Cocaine; Male; Mice; Substance Withdrawal Syndrome | 2017 |
Withdrawal-like behavior in planarians is dependent on drug exposure duration.
Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Methamphetamine; Motor Activity; Planarians; Substance Withdrawal Syndrome; Time Factors | 2008 |
Increased impulsivity during withdrawal from cocaine self-administration: role for DeltaFosB in the orbitofrontal cortex.
Topics: Adenoviridae; Animals; Cocaine; Cocaine-Related Disorders; Cognition; Dose-Response Relationship, Drug; Extinction, Psychological; Gene Transfer Techniques; Genetic Vectors; Immunohistochemistry; Impulsive Behavior; Male; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Rats; Rats, Long-Evans; Reaction Time; Self Administration; Substance Withdrawal Syndrome | 2009 |
Evidence for beta1-adrenergic receptor involvement in amygdalar corticotropin-releasing factor gene expression: implications for cocaine withdrawal.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Amygdala; Animals; Betaxolol; Cell Nucleus; Central Nervous System Stimulants; Cocaine; Corticotropin-Releasing Hormone; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Gene Expression; Male; Neurons; Phosphorylation; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; RNA, Messenger; Substance Withdrawal Syndrome | 2009 |
Cocaine withdrawal enhances pentobarbital-induced sleep in rats: evidence of GABAergic modulation.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Drug Synergism; GABA Modulators; Glutamate Decarboxylase; Male; Pentobarbital; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sleep; Substance Withdrawal Syndrome; Time Factors | 2008 |
Immunosuppression induced by a conditioned stimulus associated with cocaine self-administration.
Topics: Animals; Cell Proliferation; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corticosterone; Extinction, Psychological; Immune Tolerance; Immunity, Cellular; Interleukin-10; Male; Organ Size; Rats; Rats, Wistar; Self Administration; Spleen; Substance Withdrawal Syndrome; Tumor Necrosis Factor-alpha | 2008 |
Haloperidol (but not ziprasidone) withdrawal potentiates sensitization to the hyperlocomotor effect of cocaine in mice.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Haloperidol; Humans; Male; Mice; Motor Activity; Piperazines; Schizophrenia; Substance Withdrawal Syndrome; Thiazoles | 2008 |
Neuroadaptive changes in the rat brain GABA(B) receptors after withdrawal from cocaine self-administration.
Topics: Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Male; Protein Binding; Rats; Rats, Wistar; Receptors, GABA-B; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2008 |
Hormonal, neurochemical, and behavioral response to a forced swim test in adolescent rats throughout cocaine withdrawal.
Topics: Animals; Behavior, Animal; Cocaine; Corticosterone; Dopamine; Female; Humans; Male; Motor Activity; Rats; Rats, Wistar; Serotonin; Substance Withdrawal Syndrome; Swimming | 2008 |
Effects of ginseng saponin on acute cocaine-induced alterations in evoked dopamine release and uptake in rat brain nucleus accumbens.
Topics: Analysis of Variance; Animals; Area Under Curve; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Ginsenosides; In Vitro Techniques; Male; Models, Animal; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2009 |
Renewed cocaine exposure produces transient alterations in nucleus accumbens AMPA receptor-mediated behavior.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Motor Activity; Neuronal Plasticity; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Dopamine D1; Substance Withdrawal Syndrome; Synaptic Transmission | 2008 |
Integrin expression is altered after acute and chronic cocaine.
Topics: Actins; Acute Disease; Animals; Chronic Disease; Cocaine; Cocaine-Related Disorders; Dendrites; Disease Models, Animal; Dopamine Uptake Inhibitors; Down-Regulation; Drug Administration Schedule; Integrin beta1; Integrin beta3; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Substance Withdrawal Syndrome; Synaptic Membranes; Up-Regulation | 2009 |
Behavioral sensitization to cocaine is associated with increased glutamate receptor trafficking to the postsynaptic density after extended withdrawal period.
Topics: Actins; Animals; Behavior, Animal; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disks Large Homolog 4 Protein; Dopamine Uptake Inhibitors; Gene Expression Regulation; Homer Scaffolding Proteins; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Substance Withdrawal Syndrome; Synaptosomes; Time Factors; Ventral Tegmental Area | 2009 |
Locomotor sensitization to cocaine is associated with distinct pattern of glutamate receptor trafficking to the postsynaptic density in prefrontal cortex: early versus late withdrawal effects.
Topics: Animals; Cocaine; Locomotion; Male; Prefrontal Cortex; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Subcellular Fractions; Substance Withdrawal Syndrome; Synapses | 2009 |
Self administration of heroin and cocaine in morphine-dependent and morphine-withdrawn rhesus monkeys.
Topics: Animals; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Heroin; Macaca mulatta; Male; Morphine Dependence; Narcotics; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome | 2009 |
Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Excitatory Postsynaptic Potentials; Glutamic Acid; GTP-Binding Proteins; Male; Organ Culture Techniques; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Substance Withdrawal Syndrome; Synaptic Transmission | 2009 |
Altered dendritic spine plasticity in cocaine-withdrawn rats.
Topics: Actins; Animals; Blotting, Western; Cell Count; Cocaine; Cytoskeleton; Dendritic Spines; Electric Stimulation; Evoked Potentials; Extracellular Space; Image Processing, Computer-Assisted; Male; Microscopy, Confocal; Neuronal Plasticity; Rats; Rats, Wistar; Subcellular Fractions; Substance Withdrawal Syndrome; Synapses | 2009 |
Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; beta-Endorphin; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Recurrence; Reward; Self Administration; Substance Withdrawal Syndrome | 2009 |
GABA(A) receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Cocaine; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethanol; Female; Functional Laterality; GABA Antagonists; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Motivation; Narcotics; Pedunculopontine Tegmental Nucleus; Receptors, Dopamine D2; Receptors, GABA-A; Reinforcement, Psychology; Substance Withdrawal Syndrome; Time Factors | 2009 |
Effects of abstinence or extinction on cocaine seeking as a function of withdrawal duration.
Topics: Animals; Cocaine; Conditioning, Operant; Cues; Extinction, Psychological; Male; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2009 |
Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving.
Topics: Animals; Antibodies, Blocking; Cell Line; Cocaine; Cocaine-Related Disorders; Cues; Dependovirus; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Male; Neuroglia; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2009 |
Plasticity of L-type Ca2+ channels after cocaine withdrawal.
Topics: Analysis of Variance; Animals; Calcium Channels; Calcium Channels, L-Type; Cocaine; Cross-Linking Reagents; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dopamine Uptake Inhibitors; Gene Expression Regulation; In Vitro Techniques; Male; Motor Activity; Motor Cortex; Neuronal Plasticity; Prefrontal Cortex; Protein Transport; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Time Factors | 2009 |
Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2.
Topics: Analysis of Variance; Aniline Compounds; Animals; Cocaine; Dopamine Uptake Inhibitors; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Male; Membrane Potentials; Microelectrodes; Neurons; Peptide Fragments; Peptides, Cyclic; Pyrimidines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome | 2009 |
Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis.
Topics: Animals; Cocaine; Ethanol; Heroin; Long-Term Potentiation; Rats; Rats, Wistar; Self Administration; Septal Nuclei; Substance Withdrawal Syndrome | 2009 |
Dopamine and serotonin transporter availability during acute alcohol withdrawal: effects of comorbid tobacco smoking.
Topics: Adult; Alcohol Drinking; Brain; Brain Mapping; Case-Control Studies; Cocaine; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Protein Binding; Radiopharmaceuticals; Serotonin Plasma Membrane Transport Proteins; Smoking; Statistics as Topic; Substance Withdrawal Syndrome; Tomography, Emission-Computed, Single-Photon; Young Adult | 2009 |
Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Net; Neural Pathways; Neuronal Plasticity; Nucleus Accumbens; Organ Culture Techniques; Receptors, Metabotropic Glutamate; Recurrence; Substance Withdrawal Syndrome; Synaptic Transmission; Ventral Tegmental Area | 2009 |
Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disks Large Homolog 4 Protein; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Neuronal Plasticity; Phosphorylation; Protein Serine-Threonine Kinases; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Recombinant Fusion Proteins; Serine; Substance Withdrawal Syndrome; Synapsins | 2010 |
Acquisition of and withdrawal from cocaine self-administration regulates 5-HT mRNA expression in rat striatum.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine Uptake Inhibitors; Gene Expression Regulation; Male; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; RNA, Messenger; Self Administration; Serotonin; Substance Withdrawal Syndrome | 2009 |
Anti-craving effects of environmental enrichment.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Environment; Extinction, Psychological; Housing, Animal; Male; Models, Animal; Motivation; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Secondary Prevention; Self Administration; Social Behavior; Social Isolation; Substance Withdrawal Syndrome; Time Factors | 2009 |
Effects of extended cocaine access and cocaine withdrawal on choice between cocaine and food in rhesus monkeys.
Topics: Animals; Choice Behavior; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Food; Food Preferences; Macaca mulatta; Male; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2010 |
Cocaine withdrawal-induced anxiety in females: impact of circulating estrogen and potential use of delta-opioid receptor agonists for treatment.
Topics: Analysis of Variance; Animals; Anxiety; Benzamides; Body Weight; Cocaine; Disease Models, Animal; Estrogens; Female; Maze Learning; Motor Activity; Ovariectomy; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substance Withdrawal Syndrome | 2010 |
The role of glutamate receptor redistribution in locomotor sensitization to cocaine.
Topics: Animals; Cocaine; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Substance Withdrawal Syndrome | 2010 |
Effects of clozapine on behavioral sensitization induced by cocaine.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cocaine; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Extracellular Signal-Regulated MAP Kinases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred ICR; Motor Activity; Oncogene Protein v-akt; Prefrontal Cortex; Signal Transduction; Substance Withdrawal Syndrome | 2010 |
Anxiety-like responses in adolescent rats following a 10-11-day withdrawal period from repeated cocaine administration.
Topics: Aging; Analysis of Variance; Animals; Anxiety; Cocaine; Dopamine Uptake Inhibitors; Male; Maze Learning; Neuropsychological Tests; Rats; Rats, Long-Evans; Substance Withdrawal Syndrome; Time Factors | 2010 |
Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats.
Topics: Animals; Biological Transport; Caudate Nucleus; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane Transport Proteins; Extinction, Psychological; Male; Nucleus Accumbens; Phosphorylation; Protein Phosphatase 2; Putamen; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 2010 |
Increased error-related thalamic activity during early compared to late cocaine abstinence.
Topics: Adult; Cerebral Cortex; Cocaine; Data Interpretation, Statistical; Dopamine Uptake Inhibitors; Female; Humans; Impulsive Behavior; Magnetic Resonance Imaging; Male; Psychiatric Status Rating Scales; Psychomotor Performance; Reaction Time; Recurrence; Substance Withdrawal Syndrome; Thalamus; Time Factors | 2010 |
Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration.
Topics: Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Gene Expression; Male; Nucleus Accumbens; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2010 |
Normalizing effects of modafinil on cocaine-induced sleep abnormalities.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Humans; Modafinil; Polysomnography; Randomized Controlled Trials as Topic; Sleep Wake Disorders; Substance Withdrawal Syndrome | 2010 |
Effect of the use-dependent, nicotinic receptor antagonist BTMPS in the forced swim test and elevated plus maze after cocaine discontinuation in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Decanoic Acids; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Male; Maze Learning; Nicotinic Antagonists; Piperidines; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Swimming | 2010 |
Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents.
Topics: Animals; Benzhydryl Compounds; Biogenic Monoamines; Central Nervous System Stimulants; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mice; Mice, Inbred C57BL; Modafinil; Motor Activity; Neurotransmitter Uptake Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Wakefulness | 2010 |
Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal.
Topics: Amygdala; Animals; Cocaine; Corticotropin-Releasing Hormone; Disease Models, Animal; Dopamine Agents; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agents; GABA Agents; In Vitro Techniques; Long-Term Potentiation; Male; Models, Neurological; Motor Activity; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Substance Withdrawal Syndrome; Time Factors | 2010 |
Inhibition of actin polymerization prevents cocaine-induced changes in spine morphology in the nucleus accumbens.
Topics: Actins; Animals; Cocaine; Dendritic Spines; Male; Nucleus Accumbens; Protein Multimerization; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2010 |
Cocaine-induced changes in affective state modulate the light-enhanced startle response.
Topics: Affect; Animals; Anxiety; Central Nervous System Agents; Cocaine; Male; Photic Stimulation; Rats; Reflex, Startle; Substance Withdrawal Syndrome; Time Factors; Visual Perception | 2010 |
Dopamine receptor expression and distribution dynamically change in the rat nucleus accumbens after withdrawal from cocaine self-administration.
Topics: Animals; Appetitive Behavior; Cell Membrane; Cocaine; Cocaine-Related Disorders; Cues; Cytoplasm; Gene Expression Regulation; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2010 |
Acute withdrawal from chronic escalating-dose binge cocaine administration alters kappa opioid receptor stimulation of [35S] guanosine 5'-O-[gamma-thio]triphosphate acid binding in the rat ventral tegmental area.
Topics: Animals; Autoradiography; Benzeneacetamides; Cocaine; Guanosine 5'-O-(3-Thiotriphosphate); Male; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Substantia Nigra; Ventral Tegmental Area | 2010 |
Two scales to evaluate cocaine craving.
Topics: Adolescent; Adult; Cocaine; Cocaine-Related Disorders; Cross-Cultural Comparison; Cues; Dopamine Uptake Inhibitors; Female; Humans; Illicit Drugs; Male; Middle Aged; Principal Component Analysis; Psychometrics; Reproducibility of Results; Self Efficacy; Spain; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Surveys and Questionnaires; Translating; Young Adult | 2010 |
First evidence that drugs of abuse produce behavioral sensitization and cross sensitization in planarians.
Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hypnotics and Sedatives; Methamphetamine; Motor Activity; Muscarinic Antagonists; Planarians; Scopolamine; Substance Withdrawal Syndrome; Substance-Related Disorders | 2010 |
Daily life hour by hour, with and without cocaine: an ecological momentary assessment study.
Topics: Adult; Affect; Cocaine; Cocaine-Related Disorders; Cohort Studies; Computers, Handheld; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Narcotics; Recurrence; Substance Withdrawal Syndrome; Time Factors; Young Adult | 2010 |
Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal.
Topics: Animals; Blotting, Western; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Gene Expression Regulation; Injections, Intravenous; Male; Neostriatum; Nerve Tissue Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reinforcement, Psychology; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Self Administration; Substance Abuse, Intravenous; Substance Withdrawal Syndrome | 2010 |
Altered dopamine modulation of inhibition in the prefrontal cortex of cocaine-sensitized rats.
Topics: Animals; Behavior, Addictive; Cocaine; Dopamine; Inhibitory Postsynaptic Potentials; Male; Neural Inhibition; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Substance Withdrawal Syndrome | 2010 |
Involvement of tissue plasminogen activator in stress responsivity during acute cocaine withdrawal in mice.
Topics: Amygdala; Animals; Cocaine; Corticosterone; Corticotropin-Releasing Hormone; Hippocampus; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred C57BL; Pituitary-Adrenal System; Plasminogen Activator Inhibitor 1; Pro-Opiomelanocortin; RNA, Messenger; Stress, Physiological; Substance Withdrawal Syndrome; Tissue Plasminogen Activator | 2010 |
Acute brain metabolic effects of cocaine in rhesus monkeys with a history of cocaine use.
Topics: Animals; Brain; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Female; Fluorodeoxyglucose F18; Injections, Intramuscular; Injections, Intravenous; Macaca mulatta; Male; Positron-Emission Tomography; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome | 2010 |
Reinforcer-dependent enhancement of operant responding in opioid-withdrawn rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement Schedule; Remifentanil; Self Administration; Substance Withdrawal Syndrome | 2010 |
High cocaine dosage decreases neurogenesis in the hippocampus and impairs working memory.
Topics: Animals; Cell Division; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dentate Gyrus; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Hippocampus; Male; Maze Learning; Memory, Short-Term; Neurogenesis; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 2011 |
Roles of two subtypes of corticotrophin-releasing factor receptor in the corticostriatal long-term potentiation under cocaine withdrawal condition.
Topics: Animals; Cerebral Cortex; Cocaine; Corpus Striatum; Corticotropin-Releasing Hormone; Electrophysiology; Long-Term Potentiation; Male; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome; Synapses; Urocortins; Ventral Tegmental Area | 2010 |
Inhibition of neuronal nitric oxide synthase prevents alterations in medial prefrontal cortex excitability induced by repeated cocaine administration.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Enzyme Inhibitors; Indazoles; Male; Nitric Oxide Synthase Type I; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Reward; Substance Withdrawal Syndrome | 2011 |
Protracted cocaine withdrawal produces circadian rhythmic alterations of phosphorylated GSK-3β in reward-related brain areas in rats.
Topics: Analysis of Variance; Animals; Blotting, Western; Circadian Rhythm; Cocaine; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Motor Activity; Nucleus Accumbens; Phosphorylation; Rats; Rats, Sprague-Dawley; Reward; Substance Withdrawal Syndrome; Suprachiasmatic Nucleus; Ventral Tegmental Area | 2011 |
A multistudy analysis of the effects of early cocaine abstinence on sleep.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Female; Humans; Male; Middle Aged; Polysomnography; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Stages; Substance Withdrawal Syndrome; Time Factors; Young Adult | 2011 |
Dorsal striatum mediation of cocaine-seeking after withdrawal from short or long daily access cocaine self-administration in rats.
Topics: Analysis of Variance; Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Corpus Striatum; Drug-Seeking Behavior; Extinction, Psychological; Male; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2011 |
Differential glutamate AMPA-receptor plasticity in subpopulations of VTA neurons in the presence or absence of residual cocaine: implications for the development of addiction.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dendrites; Dopamine Uptake Inhibitors; Dopaminergic Neurons; GABAergic Neurons; Male; Mice; Mice, Inbred C57BL; Multivesicular Bodies; Nerve Tissue Proteins; Neuronal Plasticity; Protein Subunits; Protein Transport; Random Allocation; Receptors, AMPA; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2011 |
Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²⁺-permeable AMPA receptors during the incubation of cocaine craving.
Topics: Animals; Behavior, Animal; Calcium Channels; Calcium Signaling; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Male; Nerve Tissue Proteins; Neurons; Nucleus Accumbens; Phosphorylation; Protein Processing, Post-Translational; Protein Subunits; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Substance Withdrawal Syndrome | 2011 |
Cocaine-induced plasticity in the nucleus accumbens is cell specific and develops without prolonged withdrawal.
Topics: Animals; Cocaine; Dendritic Spines; Electrophysiology; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Green Fluorescent Proteins; Injections, Intraperitoneal; Locomotion; Male; Mice; Mice, Transgenic; Motor Activity; Neuronal Plasticity; Neuropsychological Tests; Nucleus Accumbens; Random Allocation; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Time Factors | 2011 |
Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking.
Topics: Acetylcysteine; Animals; Cocaine; Cocaine-Related Disorders; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Glutamic Acid; Homeostasis; Male; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome | 2011 |
Emergence of context-associated GluR(1) and ERK phosphorylation in the nucleus accumbens core during withdrawal from cocaine self-administration.
Topics: Animals; Association Learning; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Extracellular Signal-Regulated MAP Kinases; Male; MAP Kinase Signaling System; Neostriatum; Nucleus Accumbens; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Self Administration; Social Environment; Substance Withdrawal Syndrome | 2011 |
Increased non-rapid eye movement sleep by cocaine withdrawal: possible involvement of A2A receptors.
Topics: Animals; Behavior, Animal; Cocaine; Electroencephalography; Male; Motor Activity; Polysomnography; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Sleep; Sleep, REM; Substance Withdrawal Syndrome; Wakefulness | 2011 |
Cocaine withdrawal impairs metabotropic glutamate receptor-dependent long-term depression in the nucleus accumbens.
Topics: Analysis of Variance; Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Electrophysiology; Enzyme-Linked Immunosorbent Assay; Long-Term Synaptic Depression; Male; Mice; Motor Activity; Nucleus Accumbens; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; Substance Withdrawal Syndrome; Synaptic Transmission | 2011 |
Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Endocytosis; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Male; Memory; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Oligopeptides; Organophosphonates; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reward; Substance Withdrawal Syndrome; Time Factors; Valine | 2011 |
Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine.
Topics: Animals; Behavior, Animal; Blotting, Western; Calcium; Cocaine; Cocaine-Related Disorders; Cross-Linking Reagents; Electrophysiological Phenomena; Male; Motor Activity; Neuronal Plasticity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Self Administration; Substance Withdrawal Syndrome; Synapses | 2011 |
Effects of daily morphine administration and deprivation on choice and demand for remifentanil and cocaine in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Choice Behavior; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Macaca mulatta; Male; Morphine; Morphine Dependence; Motivation; Piperidines; Remifentanil; Substance Withdrawal Syndrome | 2011 |
Withdrawal from chronic cocaine administration induces deficits in brain reward function in C57BL/6J mice.
Topics: Animals; Brain; Choice Behavior; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Infusion Pumps, Implantable; Male; Mice; Mice, Inbred C57BL; Microinjections; Motor Activity; Reward; Self Stimulation; Substance Withdrawal Syndrome | 2011 |
Persistent increase in hypothalamic arginine vasopressin gene expression during protracted withdrawal from chronic escalating-dose cocaine in rodents.
Topics: Animals; Arginine Vasopressin; Cocaine; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Transgenic; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Promoter Regions, Genetic; Rats; Rats, Inbred F344; Stress, Physiological; Substance Withdrawal Syndrome; Time Factors; Up-Regulation | 2011 |
Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Depression; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Routes; Immobility Response, Tonic; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome; Swimming; Time Factors | 2012 |
Cocaine withdrawal reduces group I mGluR-mediated long-term potentiation via decreased GABAergic transmission in the amygdala.
Topics: Amygdala; Animals; Behavior, Animal; Cocaine; Conditioning, Psychological; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Long-Term Potentiation; Male; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Synaptic Transmission | 2011 |
Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats.
Topics: Amygdala; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corticotropin-Releasing Hormone; Extinction, Psychological; Male; Rats; Rats, Wistar; Self Administration; Stress, Psychological; Substance Withdrawal Syndrome | 2012 |
Antagonism of cannabinoid 1 receptors reverses the anxiety-like behavior induced by central injections of corticotropin-releasing factor and cocaine withdrawal.
Topics: Animals; Anxiety; Behavior, Animal; Cocaine; Corticosterone; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Hypothalamo-Hypophyseal System; Male; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome | 2012 |
Decreased proliferation of adult hippocampal stem cells during cocaine withdrawal: possible role of the cell fate regulator FADD.
Topics: Adult Stem Cells; Animals; Cell Count; Cell Proliferation; Cocaine; Cocaine-Related Disorders; Down-Regulation; Fas-Associated Death Domain Protein; Growth Inhibitors; Hippocampus; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2011 |
Environmental enrichment counters cocaine abstinence-induced stress and brain reactivity to cocaine cues but fails to prevent the incubation effect.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corticosterone; Cues; Drug-Seeking Behavior; eIF-2 Kinase; Environment; Extinction, Psychological; In Vitro Techniques; Male; MAP Kinase Signaling System; Motivation; Rats; Rats, Sprague-Dawley; Self Administration; Social Isolation; Stress, Psychological; Substance Withdrawal Syndrome | 2012 |
Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala.
Topics: Amygdala; Animals; Behavior, Animal; Benzazepines; Cocaine; Conditioning, Psychological; Cues; Cyclopropanes; Dopamine; gamma-Aminobutyric Acid; Gene Expression Regulation, Enzymologic; Glycine; Isoenzymes; Long-Term Potentiation; Male; Memory; Neuronal Plasticity; Phospholipase D; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D5; Receptors, Metabotropic Glutamate; Substance Withdrawal Syndrome; Synapses | 2011 |
Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters.
Topics: Acetylation; Anesthetics, Local; Animals; Brain-Derived Neurotrophic Factor; Chromatin Immunoprecipitation; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; CREB-Binding Protein; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Histones; Male; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; RNA, Messenger; Self Administration; Statistics, Nonparametric; Substance Withdrawal Syndrome; Time Factors; Ventral Tegmental Area | 2012 |
Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats.
Topics: Anesthetics, Local; Animals; Brain-Derived Neurotrophic Factor; Cocaine; Conditioning, Operant; CREB-Binding Protein; Drug Administration Routes; Extinction, Psychological; Gene Expression Regulation; Green Fluorescent Proteins; Male; Mutation; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology; RNA Interference; Self Administration; Statistics as Topic; Substance Withdrawal Syndrome; Transfection | 2011 |
Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal.
Topics: Anhedonia; Animals; Brain; Cocaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reward; Self Stimulation; Substance Withdrawal Syndrome; Time Factors | 2012 |
Reversal of cocaine withdrawal-induced anxiety by ondansetron, buspirone and propranolol.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Cocaine; Male; Motor Activity; Ondansetron; Propranolol; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2012 |
Circadian discrimination of reward: evidence for simultaneous yet separable food- and drug-entrained rhythms in the rat.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Biological Clocks; Body Temperature Regulation; Caloric Restriction; Central Nervous System Stimulants; Circadian Rhythm; Cocaine; Cocaine-Related Disorders; Discrimination, Psychological; Feeding Behavior; Male; Motor Activity; Photoperiod; Rats; Rats, Sprague-Dawley; Reward; Substance Withdrawal Syndrome; Suprachiasmatic Nucleus; Time Factors | 2012 |
Effects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice.
Topics: Animals; Association Learning; Behavior, Animal; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine Uptake Inhibitors; Drug Administration Schedule; Enkephalins; Male; Mice; Mice, Inbred C57BL; Protein Precursors; RNA, Messenger; Substance Withdrawal Syndrome | 2012 |
Treatment of cocaine withdrawal anxiety with guanfacine: relationships to cocaine intake and reinstatement of cocaine seeking in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Cocaine; Drug-Seeking Behavior; Extinction, Psychological; Guanfacine; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome | 2012 |
Protracted withdrawal from cocaine self-administration flips the switch on 5-HT(1B) receptor modulation of cocaine abuse-related behaviors.
Topics: Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Gene Transfer Techniques; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome | 2012 |
Substituting a long-acting dopamine uptake inhibitor for cocaine prevents relapse to cocaine seeking.
Topics: Analysis of Variance; Animals; Behavior, Addictive; Benztropine; Blotting, Western; Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Fas-Associated Death Domain Protein; Humans; Male; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Rats; Rats, Long-Evans; Reinforcement Schedule; Secondary Prevention; Self Administration; Substance Withdrawal Syndrome | 2013 |
Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus.
Topics: Animals; Cocaine; Corticosterone; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Male; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, Steroid; RNA, Messenger; Stress, Psychological; Substance Withdrawal Syndrome | 2012 |
Withdrawal from cocaine self-administration alters NMDA receptor-mediated Ca2+ entry in nucleus accumbens dendritic spines.
Topics: Animals; Calcium; Calcium Signaling; Cocaine; Dendritic Spines; Dopamine Uptake Inhibitors; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Time Factors | 2012 |
A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence.
Topics: Animals; Buprenorphine; Cocaine; Cocaine-Related Disorders; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2012 |
Enhanced anxiety observed in cocaine withdrawn rats is associated with altered reactivity of the dorsomedial prefrontal cortex.
Topics: Animals; Anxiety; Cocaine; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2012 |
Time course of cocaine-induced behavioral and neurochemical plasticity.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Glutamic Acid; Male; Neuronal Plasticity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2014 |
Exaggerated cue-induced reinstatement of cocaine seeking but not incubation of cocaine craving in a developmental rat model of schizophrenia.
Topics: Animals; Animals, Newborn; Brain Mapping; Cocaine; Cocaine-Related Disorders; Cues; Diagnosis, Dual (Psychiatry); Disease Models, Animal; Drug-Seeking Behavior; Extinction, Psychological; Female; Hippocampus; Rats; Rats, Long-Evans; Schizophrenia; Schizophrenic Psychology; Self Administration; Substance Withdrawal Syndrome | 2013 |
Cannabinoid receptor 1-expressing neurons in the nucleus accumbens.
Topics: Analysis of Variance; Animals; Cocaine; DNA Primers; Gene Knock-In Techniques; Immunohistochemistry; Interneurons; Male; Mice; Nucleus Accumbens; Patch-Clamp Techniques; Receptor, Cannabinoid, CB1; Signal Transduction; Substance Withdrawal Syndrome | 2012 |
Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats.
Topics: Animals; Caudate Nucleus; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Glutamic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 2012 |
Cocaine-induced loss of white matter proteins in the adult mouse nucleus accumbens is attenuated by administration of a β-lactam antibiotic during cocaine withdrawal.
Topics: Aging; Animals; beta-Lactams; Caspase 3; Ceftriaxone; Cocaine; Excitatory Amino Acid Transporter 2; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Nucleus Accumbens; Oligodendroglia; Substance Withdrawal Syndrome | 2012 |
Cognitive consequences of alterations in functional circuitry induced by chronic cocaine use and the potential impact for treatment.
Topics: Animal Experimentation; Cocaine; Cocaine-Related Disorders; Cognition; Cognition Disorders; Dopamine Uptake Inhibitors; Executive Function; Humans; Psychotropic Drugs; Substance Withdrawal Syndrome; Time; Treatment Outcome | 2012 |
Effects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome.
Topics: Animals; Cadherins; Cocaine; Down-Regulation; Gene Expression Profiling; Heterotrimeric GTP-Binding Proteins; Male; Mice; Mice, Inbred C57BL; Neuropeptides; Neurotransmitter Agents; Nucleus Accumbens; Substance Withdrawal Syndrome; Transcription, Genetic; Transcriptome; Wnt Proteins | 2013 |
Effect of drug use and influence of abstinence on sexual functioning in a Spanish male drug-dependent sample: a multisite study.
Topics: Adult; Alcoholism; Arousal; Cocaine; Drug Synergism; Ethanol; Follow-Up Studies; Heroin; Humans; Illicit Drugs; Libido; Male; Middle Aged; Orgasm; Pleasure; Sexual Dysfunction, Physiological; Sexuality; Substance Abuse Treatment Centers; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Substance-Related Disorders | 2013 |
Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: effects on striatal dopamine and opioid systems in C57BL/6J mice.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine; Dynorphins; Male; Mice; Mice, Inbred C57BL; Motor Activity; Protein Precursors; Receptors, Dopamine D1; Receptors, Dopamine D2; Substance Withdrawal Syndrome; Time Factors | 2013 |
A drug-paired taste cue elicits withdrawal and predicts cocaine self-administration.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Recurrence; Reward; Saccharin; Substance Withdrawal Syndrome; Sweetening Agents; Taste | 2013 |
Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake.
Topics: Animals; Avoidance Learning; Brain; Cocaine; Corpus Striatum; Dopamine; Dynorphins; G-Protein-Coupled Receptor Kinase 3; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microinjections; Naltrexone; Narcotic Antagonists; Nicotine; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Raphe Nuclei; Receptors, Opioid, kappa; Reward; Serotonin; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Stress, Psychological; Substance Withdrawal Syndrome; Synaptosomes | 2012 |
Nicotine reward and affective nicotine withdrawal signs are attenuated in calcium/calmodulin-dependent protein kinase IV knockout mice.
Topics: Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Cocaine; Female; Haplotypes; Humans; Linkage Disequilibrium; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nucleus Accumbens; Phenotype; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2012 |
Perinatal protein deprivation facilitates accumbal ERK phosphorylation in cocaine-sensitized adult rats.
Topics: Animals; Cocaine; Extracellular Signal-Regulated MAP Kinases; Malnutrition; Motor Activity; Nucleus Accumbens; Phosphorylation; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2013 |
Accumbal and pallidal dopamine, glutamate and GABA overflow during cocaine self-administration and its extinction in rats.
Topics: Analysis of Variance; Animals; Basal Ganglia; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamates; Male; Microdialysis; Nucleus Accumbens; Potassium Chloride; Rats; Rats, Wistar; Reinforcement, Psychology; Self Administration; Sodium Chloride; Substance Withdrawal Syndrome; Synaptic Transmission; Time Factors | 2013 |
Different roles of BDNF in nucleus accumbens core versus shell during the incubation of cue-induced cocaine craving and its long-term maintenance.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Dopamine Uptake Inhibitors; Male; Nucleus Accumbens; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, trkB; Self Administration; Substance Withdrawal Syndrome | 2013 |
The effects of continuous 5-HT(3) receptor antagonist administration on the subsequent behavioral response to cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Down-Regulation; Indazoles; Indoles; Infusion Pumps; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Stereotyped Behavior; Substance Withdrawal Syndrome; Tropanes; Tropisetron | 2002 |
Cerebrospinal fluid monoamine metabolites in cocaine patients: no relationship to cue-induced craving.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Cues; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Motivation; Norepinephrine; Serotonin; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome | 2002 |
Concurrent cocaine withdrawal alters alcohol withdrawal symptoms.
Topics: Adolescent; Adult; Alcoholism; Anti-Anxiety Agents; Cocaine; Cocaine-Related Disorders; Ethanol; Female; Humans; Male; Middle Aged; Oxazepam; Substance Withdrawal Syndrome | 2002 |
Cocaine self-administration alters the locomotor response to microinjection of bicuculline into the ventral tegmental area of rats.
Topics: Animals; Behavior, Animal; Bicuculline; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug Interactions; Drug Tolerance; GABA Antagonists; Male; Microinjections; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Self Administration; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2002 |
Ondansetron given in the acute withdrawal from a repeated cocaine sensitization dosing regimen reverses the expression of sensitization and inhibits self-administration.
Topics: Acute Disease; Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Male; Motor Activity; Ondansetron; Rats; Rats, Sprague-Dawley; Reaction Time; Self Administration; Serotonin Antagonists; Substance Withdrawal Syndrome | 2002 |
Withdrawal duration differentially affects c-fos expression in the medial prefrontal cortex and discrete subregions of the nucleus accumbens in cocaine-sensitized rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Genes, Immediate-Early; Male; Motor Activity; Nucleus Accumbens; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2002 |
Effect of cocaine and sucrose withdrawal period on extinction behavior, cue-induced reinstatement, and protein levels of the dopamine transporter and tyrosine hydroxylase in limbic and cortical areas in rats.
Topics: Animals; Cerebral Cortex; Cocaine; Conditioning, Operant; Cues; Dopamine Plasma Membrane Transport Proteins; Extinction, Psychological; Immunoblotting; Limbic System; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Long-Evans; Recurrence; Reward; Self Administration; Substance Withdrawal Syndrome; Sucrose; Tyrosine 3-Monooxygenase | 2002 |
Increases in the reinforcing efficacy of cocaine after particular histories of reinforcement.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Male; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome | 2002 |
Reinstatement and spontaneous recovery of cocaine-seeking following extinction and different durations of withdrawal.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Extinction, Psychological; Male; Rats; Recurrence; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome | 2002 |
5-HT2 receptor antagonists given in the acute withdrawal from daily cocaine injections can reverse established sensitization.
Topics: Animals; Behavior, Animal; Clozapine; Cocaine; Injections; Ketanserin; Male; Mianserin; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Substance Withdrawal Syndrome | 2002 |
Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Cocaine; Conflict, Psychological; Diazepam; Dimenhydrinate; Diphenhydramine; Dose-Response Relationship, Drug; Exploratory Behavior; Injections, Intraperitoneal; Male; Maze Learning; Rats; Rats, Long-Evans; Substance Withdrawal Syndrome | 2002 |
Cocaine treatment- and withdrawal-induced alterations in the expression and serine phosphorylation of the NR1 NMDA receptor subunit.
Topics: Animals; Brain Mapping; Cocaine; Cocaine-Related Disorders; Cyclic AMP-Dependent Protein Kinases; Disks Large Homolog 4 Protein; Down-Regulation; Frontal Lobe; Hippocampus; Immunoenzyme Techniques; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Neostriatum; Nerve Tissue Proteins; Phosphoserine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2002 |
Predictive factors of persisting illicit drug use in hospitalized heroin addicts.
Topics: Adult; Chi-Square Distribution; Cocaine; Discriminant Analysis; Female; Heroin Dependence; Humans; Illicit Drugs; Male; Methadone; Patient Admission; Predictive Value of Tests; Regression Analysis; Substance Withdrawal Syndrome | 2002 |
Diet influences cocaine withdrawal behaviors in the forced swimming test.
Topics: Animals; Behavior, Animal; Cocaine; Depression; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Male; Motor Activity; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Swimming | 2003 |
Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Plasma Membrane Transport Proteins; Half-Life; In Vitro Techniques; Injections, Intraventricular; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Membranes; Motor Activity; Neostriatum; Nerve Tissue Proteins; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tropanes | 2003 |
Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving.
Topics: Acoustic Stimulation; Amygdala; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Cues; Disease Models, Animal; Dopamine; Drug Administration Routes; Extinction, Psychological; Limbic System; Male; Nerve Growth Factor; Nucleus Accumbens; Rats; Rats, Long-Evans; Reward; Self Administration; Substance Withdrawal Syndrome; Sucrose; Time; Ventral Tegmental Area | 2003 |
Alterations in hypothalamic-pituitary-adrenal axis activity and in levels of proopiomelanocortin and corticotropin-releasing hormone-receptor 1 mRNAs in the pituitary and hypothalamus of the rat during chronic 'binge' cocaine and withdrawal.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Amygdala; Animals; Blotting, Northern; Cocaine; Corticosterone; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Enkephalins; Frontal Lobe; Hypothalamo-Hypophyseal System; Male; Pituitary Gland; Pituitary-Adrenal System; Pro-Opiomelanocortin; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred F344; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors | 2003 |
Relationships between individual sensitivity to CS- and cocaine-induced reinstatement in the rat.
Topics: Animals; Behavior, Addictive; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Male; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 2003 |
Association of cocaine withdrawal symptoms with more severe dependence and enhanced subjective response to cocaine.
Topics: Adult; Arousal; Cocaine; Cocaine-Related Disorders; Drug Synergism; Euphoria; Female; Humans; Male; Recurrence; Substance Withdrawal Syndrome | 2003 |
Stress-induced suppression of the immune system after withdrawal from chronic cocaine.
Topics: Adrenalectomy; Animals; Cell Division; Cocaine; Corticosterone; Disease Models, Animal; Dopamine Uptake Inhibitors; Hormone Antagonists; Hypersensitivity, Delayed; Immune System; Leukocytes; Male; Mifepristone; Rats; Stress, Physiological; Substance Withdrawal Syndrome; T-Lymphocyte Subsets; T-Lymphocytes | 2003 |
Forebrain astroglial plasticity is induced following withdrawal from repeated cocaine administration.
Topics: Animals; Astrocytes; Cell Count; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Glial Fibrillary Acidic Protein; Immunoblotting; Immunohistochemistry; Male; Neuronal Plasticity; Nucleus Accumbens; Prefrontal Cortex; Prosencephalon; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2003 |
Baclofen attenuates conditioned locomotion to cues associated with cocaine administration and stabilizes extracellular glutamate levels in rat nucleus accumbens.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Motor Activity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Reward; Substance Withdrawal Syndrome; Synaptic Transmission | 2003 |
CSF CRH in abstinent cocaine-dependent patients.
Topics: Adult; Cocaine; Corticotropin-Releasing Hormone; Follow-Up Studies; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Substance Withdrawal Syndrome | 2003 |
GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine.
Topics: Animals; Binding, Competitive; Chronic Disease; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Drug Administration Schedule; Extracellular Space; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Male; Microdialysis; Nucleus Accumbens; Phosphorylation; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Substance Withdrawal Syndrome; Synaptic Transmission | 2003 |
Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Donepezil; Indans; Male; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Nucleus Accumbens; Pain; Piperidines; Substance Withdrawal Syndrome | 2003 |
Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior.
Topics: Action Potentials; Animals; Behavior, Addictive; Cocaine; Dopamine; Male; Mesencephalon; Neurons; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 2003 |
Irritability following abstinence from cocaine predicts euphoric effects of cocaine administration.
Topics: Adult; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Depressive Disorder; Dopamine Uptake Inhibitors; Euphoria; Humans; Irritable Mood; Middle Aged; Substance Withdrawal Syndrome | 2003 |
Morphine and cocaine influence on CRF biosynthesis in the rat central nucleus of amygdala.
Topics: Amygdala; Analgesics, Opioid; Animals; Cocaine; Corticotropin-Releasing Hormone; Immunohistochemistry; In Situ Hybridization; Injections, Intraperitoneal; Male; Morphine; Rats; Rats, Wistar; RNA, Messenger; Substance Withdrawal Syndrome | 2003 |
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse.
Topics: Acetylcysteine; Adaptation, Physiological; Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Cystine; Dose-Response Relationship, Drug; Expectorants; Extinction, Psychological; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2003 |
Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine.
Topics: Amygdala; Animals; Brain Stem; Chronic Disease; Cocaine; Cocaine-Related Disorders; Corticosterone; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Enkephalins; Frontal Lobe; Gene Expression; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Substance Withdrawal Syndrome | 2003 |
Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats.
Topics: Adaptation, Physiological; Adenylyl Cyclases; Animals; Blotting, Western; Cocaine; Cocaine-Related Disorders; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Disease Models, Animal; Male; Nucleus Accumbens; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Self Administration; Substance Withdrawal Syndrome; Time Factors; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2003 |
Methylphenidate and MDMA adolescent exposure in mice: long-lasting consequences on cocaine-induced reward and psychomotor stimulation in adulthood.
Topics: Age Factors; Animals; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Male; Methylphenidate; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Psychomotor Performance; Reward; Substance Withdrawal Syndrome; Time Factors; Weight Gain | 2003 |
Augmented responses to morphine and cocaine in mice with a 12-lipoxygenase gene disruption.
Topics: Anesthetics, Local; Animals; Arachidonate 12-Lipoxygenase; Avoidance Learning; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Drug Tolerance; Inhibition, Psychological; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Motor Activity; Mutation; Narcotics; Pain Threshold; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance Withdrawal Syndrome; Swimming | 2003 |
[Cocaine and opiate related disorders].
Topics: Cocaine; Cocaine-Related Disorders; Drug and Narcotic Control; Humans; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome; Switzerland | 2003 |
Management of drug and alcohol withdrawal.
Topics: Adrenergic beta-Antagonists; Carbazoles; Carvedilol; Cocaine; Humans; Propanolamines; Propranolol; Substance Withdrawal Syndrome | 2003 |
Behavioral depression during cocaine withdrawal is associated with decreased spontaneous activity of ventral tegmental area dopamine neurons.
Topics: Animals; Circadian Rhythm; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Male; Motor Activity; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2003 |
Role for M5 muscarinic acetylcholine receptors in cocaine addiction.
Topics: Animals; Avoidance Learning; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Male; Mice; Mice, Transgenic; Receptor, Muscarinic M5; Receptors, Muscarinic; Self Administration; Substance Withdrawal Syndrome | 2003 |
REFLECTIONS ON HEROIN AND COCAINE ADDICTION.
Topics: Adolescent; Cocaine; Cocaine-Related Disorders; Heroin; Humans; Psychotherapy; Psychotherapy, Group; Substance Withdrawal Syndrome; Substance-Related Disorders | 1965 |
A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal.
Topics: Amygdala; Animals; Blotting, Western; Brain Chemistry; Cocaine; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Image Processing, Computer-Assisted; Male; Paraventricular Hypothalamic Nucleus; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; RGS Proteins; Substance Withdrawal Syndrome | 2003 |
Cocaine and other indirect-acting monoamine agonists differentially attenuate a naltrexone discriminative stimulus in morphine-treated rhesus monkeys.
Topics: Amphetamine; Animals; Biogenic Monoamines; Cocaine; Discrimination Learning; Disease Models, Animal; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Interactions; Imipramine; Macaca mulatta; Morphine; Morphine Dependence; Naltrexone; Narcotics; Substance Withdrawal Syndrome | 2004 |
Prolonged effects of repeated cocaine on medial prefrontal cortex dopamine response to cocaine and a stressful predatory odor challenge in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Extracellular Fluid; Microdialysis; Odorants; Prefrontal Cortex; Rats; Stress, Psychological; Substance Withdrawal Syndrome; Thiazoles; Time Factors | 2003 |
Prolonged cardiac dysfunction after withdrawal of chronic cocaine exposure in rats.
Topics: Animals; Antioxidants; Cocaine; Heart Diseases; Male; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Ventricular Dysfunction, Left | 2003 |
Neuroadaptive changes in mesocorticolimbic dopamine and acetylcholine neurons following cocaine or saline self-administration are dependent on pre-existing individual differences.
Topics: Acetylcholine; Action Potentials; Adaptation, Physiological; Amygdala; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Electric Stimulation; In Vitro Techniques; Limbic System; Male; Motivation; Neurons; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Self Administration; Sodium Chloride; Substance Withdrawal Syndrome | 2003 |
Discriminative stimulus effects of the cannabinoid antagonist, SR 141716A, in delta -sup-9-tetrahydrocannabinol-treated rhesus monkeys.
Topics: Anesthetics; Animals; Behavior, Animal; Cannabinoids; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Ketamine; Macaca mulatta; Male; Photic Stimulation; Piperidines; Psychotropic Drugs; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2003 |
Withdrawal from chronic cocaine up-regulates 5-HT1B receptors in the rat brain.
Topics: Animals; Brain; Cocaine; Discrimination Learning; Drug Administration Schedule; Male; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Substance Withdrawal Syndrome; Up-Regulation | 2003 |
Clozapine and cocaine effects on dopamine and serotonin release in nucleus accumbens during psychostimulant behavior and withdrawal.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Clozapine; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Electrophysiology; Male; Microelectrodes; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Serotonin; Substance Withdrawal Syndrome | 2004 |
Nerve terminal glutamate immunoreactivity in the rat nucleus accumbens and ventral tegmental area after a short withdrawal from cocaine.
Topics: Animals; Cocaine; Glutamic Acid; Immunochemistry; Male; Motor Activity; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2004 |
Prolonged nicotine dependence associated with extended access to nicotine self-administration in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Ganglionic Stimulants; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome; Time Factors; Tobacco Use Disorder | 2004 |
Immune cell activity during the initial stages of withdrawal from chronic exposure to cocaine or morphine.
Topics: Analysis of Variance; Animals; Cocaine; Concanavalin A; Corticosterone; Lymphocytes; Male; Mitogens; Morphine; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Thymidine; Time Factors; Tritium | 2004 |
Altered cocaine-induced behavioral sensitization in adult mice exposed to cocaine in utero.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Female; Growth; Habituation, Psychophysiologic; Male; Mice; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Stereotyped Behavior; Substance Withdrawal Syndrome | 2003 |
A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Disease Models, Animal; Enzyme Inhibitors; Extinction, Psychological; Infusions, Parenteral; Male; Nerve Growth Factor; Rats; Rats, Long-Evans; Substance Withdrawal Syndrome; Substantia Nigra; Time Factors; Ventral Tegmental Area | 2004 |
Cocaine seeking over extended withdrawal periods in rats: time dependent increases of responding induced by heroin priming over the first 3 months.
Topics: Animals; Behavior, Addictive; Cocaine; Conditioning, Operant; Disease Models, Animal; Drug Administration Schedule; Extinction, Psychological; Forecasting; Heroin; Injections, Intravenous; Injections, Subcutaneous; Male; Rats; Rats, Long-Evans; Recurrence; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2004 |
Cocaine seeking over extended withdrawal periods in rats: different time courses of responding induced by cocaine cues versus cocaine priming over the first 6 months.
Topics: Animals; Behavior, Addictive; Cocaine; Conditioning, Operant; Cues; Drug Administration Schedule; Drug Evaluation, Preclinical; Extinction, Psychological; Infusion Pumps; Injections, Intraperitoneal; Male; Rats; Rats, Long-Evans; Recurrence; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2004 |
Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Dopamine D2 Receptor Antagonists; Extinction, Psychological; Infusions, Intravenous; Male; Microinjections; Nitriles; Nucleus Accumbens; Rats; Rats, Long-Evans; Receptors, Dopamine D2; Receptors, Dopamine D3; Reinforcement, Psychology; Secondary Prevention; Self Administration; Stress, Psychological; Substance Withdrawal Syndrome; Tetrahydroisoquinolines | 2004 |
Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking.
Topics: Animals; Behavior, Addictive; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Male; Oligonucleotides, Antisense; Rats; Self Administration; Substance Withdrawal Syndrome | 2004 |
Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers.
Topics: Adolescent; Adult; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Cognition Disorders; Female; Humans; Image Processing, Computer-Assisted; Male; Neuropsychological Tests; Psychometrics; Reference Values; Regional Blood Flow; Reproducibility of Results; Substance Withdrawal Syndrome; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 2004 |
Evidence for alterations in alpha2-adrenergic receptor sensitivity in rats exposed to repeated cocaine administration.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Cocaine; Cocaine-Related Disorders; Corticosterone; Depressive Disorder; Disease Models, Animal; Down-Regulation; Drug Administration Schedule; Growth Hormone; Male; Norepinephrine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Substance Withdrawal Syndrome; Synaptic Transmission | 2004 |
Increases in dopamine D3 receptor binding in rats receiving a cocaine challenge at various time points after cocaine self-administration: implications for cocaine-seeking behavior.
Topics: Animals; Autoradiography; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Agonists; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Self Administration; Substance Withdrawal Syndrome; Tetrahydronaphthalenes | 2004 |
Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats.
Topics: Animals; Behavior, Animal; Blotting, Western; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Drug Administration Schedule; Male; Neostriatum; Nucleus Accumbens; Prefrontal Cortex; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Substantia Nigra; Ventral Tegmental Area | 2004 |
Short-term cocaine treatment causes neuroadaptive changes in Galphaq and Galpha11 proteins in rats undergoing withdrawal.
Topics: Amygdala; Animals; Blotting, Western; Cocaine; Dopamine Uptake Inhibitors; GTP-Binding Protein alpha Subunits, Gq-G11; Male; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2004 |
DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine.
Topics: Analgesia; Analgesics; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Lithium Chloride; Male; Mice; Mice, Knockout; Morphine; Motivation; Motor Activity; Naloxone; Narcotic Antagonists; Reaction Time; Repressor Proteins; Substance Withdrawal Syndrome; Transcription Factors | 2004 |
Modulation of long-term potentiation in the rat hippocampus following cocaine self-administration.
Topics: Adaptation, Physiological; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Male; Memory; Neurons; Rats; Rats, Sprague-Dawley; Reaction Time; Self Administration; Substance Withdrawal Syndrome; Synaptic Transmission; Time Factors | 2004 |
The effects of continuous cocaine dose, treatment, and withdrawal duration on the induction of behavioral tolerance and dopamine autoreceptor function.
Topics: Animals; Autoreceptors; Cocaine; Drug Tolerance; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Substance Withdrawal Syndrome | 2004 |
Chronic opiate treatment enhances both cocaine-reinforced and cocaine-seeking behaviors following opiate withdrawal.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Male; Morphine; Narcotics; Rats; Rats, Wistar; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome | 2004 |
Cocaine and kappa-opioid withdrawal in Planaria blocked by D-, but not L-, glucose.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Behavior, Addictive; Carbohydrate Conformation; Cocaine; Disease Models, Animal; Glucose; Narcotic Antagonists; Opioid-Related Disorders; Planarians; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2004 |
Binge self-administration and deprivation produces sensitization to the reinforcing effects of cocaine in rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Motivation; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Substance Abuse, Intravenous; Substance Withdrawal Syndrome | 2005 |
Influence of handling or aversive stimulation during rats' neonatal or adolescence periods on oral cocaine self-administration and cocaine withdrawal.
Topics: Adolescent; Age Factors; Animals; Animals, Newborn; Cocaine; Cocaine-Related Disorders; Depression; Disease Models, Animal; Dopamine Uptake Inhibitors; Female; Humans; Male; Physical Conditioning, Animal; Rats; Rats, Wistar; Risk Factors; Stress, Psychological; Substance Withdrawal Syndrome | 2004 |
Reboxetine in cocaine withdrawal treatment: a three cases report.
Topics: Adult; Antidepressive Agents; Cocaine; Humans; Male; Morpholines; Reboxetine; Substance Withdrawal Syndrome | 2003 |
Identification of tyrosine hydroxylase as a physiological substrate for Cdk5.
Topics: Animals; Binding Sites; Cattle; Cocaine; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Neostriatum; Nerve Tissue Proteins; Neurons; Phosphoproteins; Phosphorylation; Purines; Rats; Roscovitine; Self Administration; Signal Transduction; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase | 2004 |
Ondansetron, given during the acute cocaine withdrawal, attenuates oral cocaine self-administration.
Topics: Administration, Oral; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Male; Ondansetron; Rats; Rats, Sprague-Dawley; Self Administration; Serotonin Antagonists; Stereotyped Behavior; Substance Withdrawal Syndrome | 2004 |
[Assessment of disorders after chronic psychoactive drug abuse in patients hospitalized in detoxification units].
Topics: Adolescent; Adult; Amphetamine; Amphetamine-Related Disorders; Cannabis; Cocaine; Cocaine-Related Disorders; Female; Hospitalization; Humans; Male; Marijuana Abuse; Middle Aged; N-Methyl-3,4-methylenedioxyamphetamine; Narcotics; Opioid-Related Disorders; Poland; Psychotropic Drugs; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome | 2004 |
[Depression started suddenly from a fist's blow to the head].
Topics: Acute Disease; Bipolar Disorder; Cocaine; Depression; Diagnosis, Differential; Finland; Follow-Up Studies; Humans; Male; Middle Aged; Psychotherapy; Risk Assessment; Severity of Illness Index; Spouse Abuse; Substance Withdrawal Syndrome | 2004 |
Central amygdala ERK signaling pathway is critical to incubation of cocaine craving.
Topics: Amygdala; Anesthetics, Local; Animals; Behavior, Addictive; Behavior, Animal; Blotting, Western; Butadienes; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Extinction, Psychological; Extracellular Signal-Regulated MAP Kinases; Food; Injections, Intravenous; Male; N-Methylaspartate; Nitriles; Phosphorylation; Rats; Rats, Long-Evans; Reinforcement, Psychology; Self Administration; Signal Transduction; Substance Withdrawal Syndrome; Time Factors | 2005 |
Acute and chronic continuous methamphetamine have different long-term behavioral and neurochemical consequences.
Topics: Animals; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Circadian Rhythm; Cocaine; Cold Temperature; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Electrophysiology; Fever; Infusion Pumps, Implantable; Male; Methamphetamine; Motor Activity; Quinpirole; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Time Factors; Weight Gain | 2005 |
Reduced dopamine terminal function and insensitivity to cocaine following cocaine binge self-administration and deprivation.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cocaine; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Extracellular Space; In Vitro Techniques; Male; Microdialysis; Nucleus Accumbens; Presynaptic Terminals; Quinpirole; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2005 |
Monoaminergic drugs and directly observable signs of LAAM withdrawal in rhesus monkeys.
Topics: Adrenergic alpha-Agonists; Amphetamine; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Clonidine; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Haloperidol; Imipramine; Macaca mulatta; Male; Methadyl Acetate; Muscle Rigidity; Naltrexone; Narcotic Antagonists; Respiratory Mechanics; Salivation; Substance Withdrawal Syndrome | 2005 |
Maintenance of conditioned place preferences and aversion in C57BL6 mice: effects of repeated and drug state testing.
Topics: Anesthetics, Local; Animals; Avoidance Learning; Behavior, Animal; Cocaine; Conditioning, Operant; Drug Administration Schedule; Extinction, Psychological; Locomotion; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Substance Withdrawal Syndrome; Time Factors | 2005 |
Conditioned rewarding stimulus associated with cocaine self-administration reverses the depression of catecholamine brain systems following cocaine withdrawal in rats.
Topics: Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Dopamine; Extinction, Psychological; Male; Norepinephrine; Rats; Rats, Wistar; Reward; Serotonin; Substance Withdrawal Syndrome | 2006 |
Persistent upregulation of mu-opioid, but not adenosine, receptors in brains of long-term withdrawn escalating dose "binge" cocaine-treated rats.
Topics: Adenosine; Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Brain; Brain Mapping; Cocaine; Dopamine Uptake Inhibitors; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Phenethylamines; Protein Binding; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Receptors, Purinergic P1; Substance Withdrawal Syndrome; Tritium; Up-Regulation; Xanthines | 2005 |
Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex.
Topics: Animals; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Down-Regulation; Drug Administration Schedule; Enkephalins; Frontal Lobe; Male; Narcotic Antagonists; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Opioid, mu; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors | 2005 |
Differential long-term neuroadaptations of glutamate receptors in the basolateral and central amygdala after withdrawal from cocaine self-administration in rats.
Topics: Adaptation, Physiological; Amygdala; Animals; Cocaine; Male; Rats; Rats, Long-Evans; Receptors, Glutamate; Self Administration; Substance Withdrawal Syndrome; Time | 2005 |
Cognitive impairment in acute cocaine withdrawal.
Topics: Acute Disease; Adult; Case-Control Studies; Cocaine; Cognition Disorders; Dopamine Uptake Inhibitors; Female; Humans; Male; Middle Aged; Norepinephrine; Substance Withdrawal Syndrome | 2005 |
Amygdalar vasopressin mRNA increases in acute cocaine withdrawal: evidence for opioid receptor modulation.
Topics: Amygdala; Animals; Arginine Vasopressin; Cocaine; Dopamine Uptake Inhibitors; Gene Expression; Hypothalamo-Hypophyseal System; Hypothalamus; Male; Naloxone; Narcotic Antagonists; Pituitary-Adrenal System; Pro-Opiomelanocortin; Rats; Rats, Inbred F344; Receptors, Opioid, mu; RNA, Messenger; Substance Withdrawal Syndrome | 2005 |
Extended cocaine self-administration and deprivation produces region-specific and time-dependent changes in connexin36 expression in rat brain.
Topics: Animals; Brain; Cell Communication; Cocaine; Cocaine-Related Disorders; Connexins; Disease Models, Animal; Dopamine Uptake Inhibitors; Down-Regulation; Gap Junction delta-2 Protein; Gap Junctions; Hippocampus; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2005 |
Prolonged daily exposure to i.v. cocaine results in tolerance to its stimulant effects.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Drug Tolerance; Food; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome | 2005 |
Differential regulation of ionotropic glutamate receptor subunits following cocaine self-administration.
Topics: Animals; Brain; Caudate Nucleus; Cocaine; Dopamine Uptake Inhibitors; Male; Neural Pathways; Nucleus Accumbens; Protein Subunits; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2005 |
The validity and reliability of a brief measure of cocaine craving.
Topics: Adult; Affect; Cocaine; Cocaine-Related Disorders; Female; Humans; Male; Middle Aged; Personality Inventory; Psychometrics; Reproducibility of Results; Statistics as Topic; Substance Withdrawal Syndrome; Surveys and Questionnaires | 2006 |
Discrete-trials heroin self-administration produces sensitization to the reinforcing effects of cocaine in rats.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Heroin; Male; Narcotics; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome | 2006 |
LTP in the lateral amygdala during cocaine withdrawal.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fear; GABA Agonists; Long-Term Potentiation; Male; Muscimol; Rats; Rats, Sprague-Dawley; Reflex, Startle; Self Administration; Substance Withdrawal Syndrome; Synaptic Transmission; Time Factors | 2006 |
Alterations in BDNF and trkB mRNAs following acute or sensitizing cocaine treatments and withdrawal.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Diagnostic Imaging; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Male; Motor Activity; Rats; Rats, Wistar; Reaction Time; Receptor, trkB; RNA, Messenger; Substance Withdrawal Syndrome; Swimming | 2006 |
Cocaine increases actin cycling: effects in the reinstatement model of drug seeking.
Topics: Actins; Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Male; Microfilament Proteins; Nerve Tissue Proteins; Neuronal Plasticity; Nucleus Accumbens; Pseudopodia; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2006 |
Time-dependent dissociation of cocaine dose-response effects on sucrose craving and locomotion.
Topics: Animals; Cocaine; Conditioning, Operant; Cues; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extinction, Psychological; Food Preferences; Male; Motor Activity; Rats; Rats, Long-Evans; Substance Withdrawal Syndrome; Sucrose; Time Factors | 2006 |
Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study.
Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Brief Psychiatric Rating Scale; Cocaine; Cocaine-Related Disorders; Comorbidity; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lamotrigine; Male; Middle Aged; Motivation; Personality Inventory; Reproducibility of Results; Substance Withdrawal Syndrome; Surveys and Questionnaires; Treatment Outcome; Triazines | 2006 |
Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration.
Topics: Animals; Behavior, Addictive; Brain; Chronic Disease; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Hyperkinesis; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Reward; Self Administration; Substance Withdrawal Syndrome | 2007 |
Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Cues; Extinction, Psychological; Male; Putamen; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2006 |
Electrolytic lesions of a discrete area within the nucleus accumbens shell attenuate the long-term expression, but not early phase, of sensitization to cocaine.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Electrolysis; Immunohistochemistry; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase | 2006 |
Neuronal substrates of relapse to cocaine-seeking behavior: role of prefrontal cortex.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Electroencephalography; Evoked Potentials; Feedback; Glutamic Acid; Male; Motivation; Nerve Net; Neurons; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome | 2005 |
Severity of dependence and motivation for treatment: comparison of marijuana- and cocaine-dependent treatment seekers.
Topics: Adult; Age Factors; Anxiety; Cannabis; Cocaine; Cocaine-Related Disorders; Comorbidity; Female; Humans; Male; Marijuana Abuse; Mood Disorders; Motivation; Patient Acceptance of Health Care; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome | 2006 |
Cocaine Craving Questionnaire: assessing craving among cocaine users in Brazil.
Topics: Adolescent; Adult; Brazil; Cocaine; Cocaine-Related Disorders; Female; Humans; Male; Middle Aged; Motivation; Psychometrics; Reproducibility of Results; Substance Withdrawal Syndrome; Surveys and Questionnaires | 2006 |
BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Electric Stimulation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Excitatory Postsynaptic Potentials; Gene Expression Regulation; In Vitro Techniques; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Synapses; Ventral Tegmental Area | 2006 |
Use of surface enhanced laser desorption/ionization-time of flight mass spectrometry (SELDI-TOF MS) to study protein expression in a rat model of cocaine withdrawal.
Topics: Animals; Behavior, Animal; Cocaine; Disease Models, Animal; Male; Protein Array Analysis; Proteins; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Subcellular Fractions; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2006 |
A nitric oxide synthase inhibitor (L-NAME) attenuates abstinence-induced withdrawal from both cocaine and a cannabinoid agonist (WIN 55212-2) in Planaria.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Morpholines; Motor Activity; Naphthalenes; NG-Nitroarginine Methyl Ester; Planarians; Substance Withdrawal Syndrome; Time Factors | 2006 |
Effect of morphine on locomotor activity and striatal monoamine metabolism in nicotine-withdrawn mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Biogenic Monoamines; Central Nervous System Stimulants; Cocaine; Dopamine; Drug Interactions; Male; Mice; Morphine; Motor Activity; Narcotics; Neostriatum; Nicotine; Norepinephrine; Nucleus Accumbens; Serotonin; Substance Withdrawal Syndrome | 2006 |
An endogenous neuroprotectant substance, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), prevents the behavioral and neurochemical effects of cocaine reinstatement in drug-dependent rats.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Limbic System; Male; Neural Pathways; Neuroprotective Agents; Norepinephrine; Rats; Reward; Secondary Prevention; Self Administration; Serotonin; Substance Withdrawal Syndrome; Tetrahydroisoquinolines; Ventral Tegmental Area | 2007 |
Subadditive withdrawal from cocaine/kappa-opioid agonist combinations in Planaria.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Anesthetics, Local; Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Planarians; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2006 |
Depression in methadone maintenance treatment patients: rate and risk factors.
Topics: Adult; Benzodiazepines; Brief Psychiatric Rating Scale; Cocaine; Cocaine-Related Disorders; Comorbidity; Cross-Sectional Studies; Depressive Disorder; Female; Humans; Incidence; Israel; Male; Mental Disorders; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Personality Inventory; Pregnancy; Risk Factors; Substance Abuse Detection; Substance Withdrawal Syndrome | 2007 |
Cocaine-mediated supersensitivity of 5-HT2A receptors in hypothalamic paraventricular nucleus is a withdrawal-induced phenomenon.
Topics: Amphetamines; Animals; Blotting, Western; Cocaine; Corticosterone; Dopamine Uptake Inhibitors; Drug Interactions; GTP-Binding Protein alpha Subunits; Iodine Isotopes; Male; Paraventricular Hypothalamic Nucleus; Protein Binding; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Time Factors | 2006 |
Biphasic alterations in serotonin-1B (5-HT1B) receptor function during abstinence from extended cocaine self-administration.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Male; Motor Activity; Neural Pathways; Nucleus Accumbens; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Reward; Self Administration; Serotonin; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Synaptic Transmission; Ventral Tegmental Area | 2006 |
Long-term potentiation (LTP) in the central amygdala (CeA) is enhanced after prolonged withdrawal from chronic cocaine and requires CRF1 receptors.
Topics: Amygdala; Animals; Calcium Channels, L-Type; Chronic Disease; Cocaine; Cocaine-Related Disorders; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Electric Stimulation; Long-Term Potentiation; Male; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Time Factors | 2007 |
Long-term neuroadaptations produced by withdrawal from repeated cocaine treatment: role of dopaminergic receptors in modulating cortical excitability.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Male; Membrane Potentials; Motor Activity; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2006 |
Nonlinear isobologram and superadditive withdrawal from cocaine: cannabinoid combinations in planarians.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cocaine; Drug Synergism; Morpholines; Naphthalenes; Planarians; Substance Withdrawal Syndrome | 2007 |
Changes in levels of D1, D2, or NMDA receptors during withdrawal from brief or extended daily access to IV cocaine.
Topics: Adaptation, Physiological; Animals; Binding, Competitive; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Glutamic Acid; Injections, Intravenous; Male; Neural Pathways; Nucleus Accumbens; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Synaptic Transmission | 2007 |
Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats.
Topics: Animals; Behavior, Animal; Blotting, Western; Cocaine; Cyclic AMP-Dependent Protein Kinases; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Uptake Inhibitors; Female; Male; Nucleus Accumbens; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Self Administration; Sex Factors; Signal Transduction; Substance Withdrawal Syndrome | 2007 |
Fos and glutamate AMPA receptor subunit coexpression associated with cue-elicited cocaine-seeking behavior in abstinent rats.
Topics: Animals; Biomarkers; Brain; Cocaine; Cocaine-Related Disorders; Cues; Dopamine Uptake Inhibitors; Exploratory Behavior; Glutamic Acid; Limbic System; Male; Protein Subunits; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Self Administration; Substance Withdrawal Syndrome; Synaptic Transmission; Up-Regulation | 2007 |
Difficulties in emotion regulation and impulse control during cocaine abstinence.
Topics: Adaptation, Psychological; Adult; Cocaine; Cocaine-Related Disorders; Emotions; Female; Humans; Impulsive Behavior; Male; Middle Aged; Personality Inventory; Substance Withdrawal Syndrome | 2007 |
Restraint-induced corticosterone secretion and hypothalamic CRH mRNA expression are augmented during acute withdrawal from chronic cocaine administration.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Corticosterone; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Feedback; Hypothalamo-Hypophyseal System; Hypothalamus; Male; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Restraint, Physical; RNA, Messenger; Stress, Psychological; Substance Withdrawal Syndrome; Time Factors; Up-Regulation | 2007 |
Cortical inhibition and excitation in abstinent cocaine-dependent patients: a transcranial magnetic stimulation study.
Topics: Adult; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Evoked Potentials, Motor; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Motor Cortex; Neural Inhibition; Substance Withdrawal Syndrome; Synaptic Transmission; Transcranial Magnetic Stimulation | 2007 |
Increase in A2A receptors in the nucleus accumbens after extended cocaine self-administration and its disappearance after cocaine withdrawal.
Topics: Animals; Behavior, Animal; Binding, Competitive; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Nucleus Accumbens; Raclopride; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome; Time Factors; Triazines; Triazoles; Tritium | 2007 |
Neurotensin receptor antagonist administered during cocaine withdrawal decreases locomotor sensitization and conditioned place preference.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Drug Administration Schedule; Male; Motor Activity; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Substance Withdrawal Syndrome; Time Factors | 2007 |
Haloperidol (but not ziprasidone) withdrawal enhances cocaine-induced locomotor activation and conditioned place preference in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Antagonists; Dopamine Uptake Inhibitors; Haloperidol; Male; Mice; Motor Activity; Substance Withdrawal Syndrome | 2007 |
Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Clonidine; Cocaine; Macaca mulatta; Male; Morphine; Morphine Dependence; Narcotics; Substance Withdrawal Syndrome | 2007 |
Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Cocaine; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Maze Learning; Morpholines; Naphthalenes; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome | 2007 |
Memory performance in abstinent 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users.
Topics: Adolescent; Adult; Amphetamine-Related Disorders; Cocaine; Cocaine-Related Disorders; Female; Humans; Male; Memory; N-Methyl-3,4-methylenedioxyamphetamine; Substance Withdrawal Syndrome; Wechsler Scales | 2007 |
Withdrawal from cocaine self-administration produces long-lasting deficits in orbitofrontal-dependent reversal learning in rats.
Topics: Animals; Behavior, Addictive; Cocaine; Cues; Extinction, Psychological; Frontal Lobe; Learning Disabilities; Male; Rats; Rats, Long-Evans; Reversal Learning; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2007 |
Elevations of FosB in the nucleus accumbens during forced cocaine abstinence correlate with divergent changes in reward function.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Gene Expression Regulation; Male; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reward; Substance Withdrawal Syndrome; Systole | 2007 |
The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats.
Topics: Animals; Basal Ganglia; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Male; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Substantia Nigra | 2007 |
Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Down-Regulation; Drug Administration Schedule; Male; Neostriatum; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, G-Protein-Coupled; Recurrence; RGS Proteins; RNA, Messenger; Self Administration; Substance Withdrawal Syndrome | 2007 |
A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine Uptake Inhibitors; Drug Administration Routes; Extracellular Signal-Regulated MAP Kinases; Male; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Secondary Prevention; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2007 |
Cocaine craving as a predictor of treatment attrition and outcomes after residential treatment for cocaine dependence.
Topics: Adult; Affect; Cocaine; Cocaine-Related Disorders; Cues; Drive; Female; Follow-Up Studies; Humans; Male; Motivation; Patient Admission; Patient Dropouts; Recurrence; Social Environment; Substance Abuse Detection; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome | 2007 |
Withdrawal from intermittent ethanol exposure increases probability of burst firing in VTA neurons in vitro.
Topics: Action Potentials; Animals; Biological Clocks; Central Nervous System Depressants; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Electrophysiology; Ethanol; Male; Motor Activity; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2007 |
Increased breakpoints on a progressive ratio schedule reinforced by IV cocaine are associated with reduced locomotor activation and reduced dopamine efflux in nucleus accumbens shell in rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Male; Microdialysis; Motivation; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration; Substance Abuse, Intravenous; Substance Withdrawal Syndrome | 2008 |
Anxiogenic effects of cocaine withdrawal in zebrafish.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Cocaine; Diazepam; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Hyperkinesis; Male; Motor Activity; Statistics, Nonparametric; Stereotyped Behavior; Substance Withdrawal Syndrome; Time Factors; Zebrafish | 2008 |
Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females.
Topics: Adult; Affect; Arousal; Cocaine; Cocaine-Related Disorders; Estradiol; Female; Humans; Hydrocortisone; Menstrual Cycle; Middle Aged; Patient Admission; Progesterone; Reference Values; Saliva; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome | 2008 |
Cell surface AMPA receptors in the rat nucleus accumbens increase during cocaine withdrawal but internalize after cocaine challenge in association with altered activation of mitogen-activated protein kinases.
Topics: Animals; Central Nervous System Agents; Cocaine; Disease Models, Animal; Male; Mitogen-Activated Protein Kinases; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Cell Surface; Substance Withdrawal Syndrome | 2007 |
Lesions of the dorsomedial frontal cortex block sensitization to the positive-reinforcing effects of cocaine.
Topics: Animals; Cocaine; Conditioning, Operant; Data Interpretation, Statistical; Excitatory Amino Acid Agonists; Ibotenic Acid; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome | 2008 |
Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the alpha7 nicotinic acetylcholine receptor subunit.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Disease Models, Animal; Drug Tolerance; Exploratory Behavior; Female; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotinic Antagonists; Receptors, Nicotinic; Substance Withdrawal Syndrome | 2007 |
Regional differences in the effects of withdrawal from repeated cocaine upon Homer and glutamate receptor expression: a two-species comparison.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Disease Models, Animal; Drug Administration Schedule; Gene Expression Regulation; Homer Scaffolding Proteins; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Substance Withdrawal Syndrome | 2007 |
Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat.
Topics: Adenylyl Cyclases; Animals; Anxiety; Behavior, Animal; Benzamides; Cocaine; Data Interpretation, Statistical; Depression; Male; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Signal Transduction; Substance Withdrawal Syndrome; Swimming | 2008 |
The kappa-opioid receptor antagonist nor-BNI inhibits cocaine and amphetamine, but not cannabinoid (WIN 52212-2), abstinence-induced withdrawal in planarians: an instance of 'pharmacologic congruence'.
Topics: Amphetamine; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Interactions; Morpholines; Naltrexone; Naphthalenes; Narcotic Antagonists; Planarians; Substance Withdrawal Syndrome; Time Factors | 2008 |
Dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate putamen and nucleus accumbens.
Topics: Animals; Caudate Nucleus; Cocaine; Dopamine Plasma Membrane Transport Proteins; Nucleus Accumbens; Protein Transport; Putamen; Rats; Self Administration; Substance Withdrawal Syndrome | 2008 |
Longitudinal ECG changes in cocaine users during extended abstinence.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Heart Conduction System; Humans; Long QT Syndrome; Male; Substance Withdrawal Syndrome | 2008 |
Protracted time-dependent increases in cocaine-seeking behavior during cocaine withdrawal in female relative to male rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Estrous Cycle; Female; Male; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration; Sex Characteristics; Substance Withdrawal Syndrome; Time Factors | 2008 |
Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cocaine; Planarians; Sesquiterpenes; Stereotyped Behavior; Substance Withdrawal Syndrome | 2008 |
Withdrawal from cocaine self-administration normalizes deficits in proliferation and enhances maturity of adult-generated hippocampal neurons.
Topics: Age Factors; Animals; Cell Proliferation; Cellular Senescence; Cocaine; Doublecortin Protein; Hippocampus; Male; Neurons; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 2008 |
The beta-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, and clorazepate in planarians.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Anti-Bacterial Agents; Ceftriaxone; Clorazepate Dipotassium; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 2; Methamphetamine; Models, Animal; Motor Activity; Planarians; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 2008 |
Cocaine experience guides dynamic changes in AMPA receptors within the nucleus accumbens.
Topics: Animals; Cocaine; Nonlinear Dynamics; Nucleus Accumbens; Receptors, AMPA; Substance Withdrawal Syndrome; Synapses; Synaptic Transmission | 2008 |
Time-dependent change of ERK phosphorylation levels in the nucleus accumbens during withdrawals from repeated cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Extracellular Signal-Regulated MAP Kinases; Male; Nucleus Accumbens; Phosphorylation; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Time Factors | 2008 |
Wheel-running behavior is altered following withdrawal from repeated cocaine in adult rats.
Topics: Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Exploratory Behavior; Habituation, Psychophysiologic; Male; Motivation; Motor Activity; Rats; Rats, Sprague-Dawley; Recurrence; Reward; Statistics, Nonparametric; Substance Withdrawal Syndrome | 2008 |
Cocaine withdrawal-induced trafficking of delta-opioid receptors in rat nucleus accumbens.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dendrites; Dopamine Uptake Inhibitors; Female; Male; Microscopy, Immunoelectron; Nucleus Accumbens; Presynaptic Terminals; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Sex Characteristics; Substance Withdrawal Syndrome; Synaptic Membranes; Synaptic Transmission | 2008 |
Effects of cocaine place conditioning, chronic escalating-dose "binge" pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague-Dawley rats.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Dynorphins; Gene Expression Regulation; Hypothalamic Area, Lateral; Intracellular Signaling Peptides and Proteins; Male; Naloxone; Narcotic Antagonists; Neuropeptides; Orexins; Protein Precursors; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors | 2008 |
Relapse to cocaine-seeking increases activity-regulated gene expression differentially in the striatum and cerebral cortex of rats following short or long periods of abstinence.
Topics: Analysis of Variance; Animals; Autoradiography; Behavior, Addictive; Cerebral Cortex; Cocaine; Corpus Striatum; Cytoskeletal Proteins; Early Growth Response Protein 1; Gene Expression; Gene Expression Profiling; In Situ Hybridization; Male; Nerve Tissue Proteins; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Recurrence; RNA, Messenger; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2008 |
The search for medications to treat stimulant dependence.
Topics: Amphetamine-Related Disorders; Benzhydryl Compounds; Brain; Bupropion; Cocaine; Cocaine-Related Disorders; Combined Modality Therapy; Drug Approval; Humans; Methamphetamine; Modafinil; Propranolol; Psychotropic Drugs; Secondary Prevention; Substance Withdrawal Syndrome; Token Economy | 2008 |
Response: anticipating new medications.
Topics: Amphetamine-Related Disorders; Cocaine; Cocaine-Related Disorders; Humans; Methamphetamine; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Psychotropic Drugs; Secondary Prevention; Substance Withdrawal Syndrome | 2008 |
Gender differences in zebrafish responses to cocaine withdrawal.
Topics: Animals; Behavior, Animal; Brain; Carbolines; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Administration Schedule; Environment; Female; GABA Antagonists; Gene Expression Regulation; Male; Motor Activity; Sex Characteristics; Stereotyped Behavior; Stress, Physiological; Substance Withdrawal Syndrome; Time Factors; Zebrafish | 2008 |
Anxiogenesis in adult rats treated chronically with cocaine during adolescence: effects of extended abstinence and 8-OH-DPAT treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Anxiety Disorders; Brain; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug Administration Schedule; Exploratory Behavior; Male; Maze Learning; Motor Activity; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Substance Withdrawal Syndrome | 2008 |
[Experimental observations on addiction and abstinence phenomena in the rat treated with analgesics].
Topics: Amphetamine; Analgesics; Animals; Cocaine; Humans; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1966 |
Diagnostic, treatment and aftercare approaches to cocaine abuse.
Topics: Aftercare; Arrhythmias, Cardiac; Cocaine; Depression, Chemical; Drug Interactions; Family; Humans; Patient Education as Topic; Physical Exertion; Psychotherapy; Seizures; Sexual Behavior; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Double-blind comparison of desipramine and placebo in withdrawal from cocaine dependence.
Topics: Adolescent; Adult; Cocaine; Desipramine; Double-Blind Method; Female; Humans; Male; Norepinephrine; Random Allocation; Substance Withdrawal Syndrome | 1984 |
Street pharmacology: uses of cocaine and heroin in the treatment of addiction.
Topics: Adult; Cocaine; Drug Interactions; Female; Heroin; Heroin Dependence; Humans; Illicit Drugs; Male; Methadone; Self Medication; Substance Withdrawal Syndrome | 1984 |
Cocaine abuse and its treatment.
Topics: Antidepressive Agents; Behavior Therapy; Cocaine; Cognition; Conditioning, Psychological; Diazepam; Drug Tolerance; Family Therapy; Humans; Lithium; Methylphenidate; Psychoses, Substance-Induced; Psychotherapy; Self Concept; Sexual Behavior; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Desipramine in the treatment of hypersomnolence following abrupt cessation of cocaine use.
Topics: Adult; Cocaine; Desipramine; Female; Humans; Sleep Wake Disorders; Substance Withdrawal Syndrome; Substance-Related Disorders | 1983 |
Intravenous clonidine self-administration by rhesus monkeys.
Topics: Animals; Blepharoptosis; Clonidine; Cocaine; Dose-Response Relationship, Drug; Humans; Macaca mulatta; Male; Self Administration; Sodium Chloride; Substance Withdrawal Syndrome | 1981 |
Reinforcing properties of clonidine in rhesus monkeys.
Topics: Animals; Behavior, Animal; Clonidine; Cocaine; Conditioning, Operant; Feeding Behavior; Humans; Macaca mulatta; Male; Reinforcement, Psychology; Restraint, Physical; Self Administration; Substance Withdrawal Syndrome | 1982 |
Body temperature response to cocaine and diazepam in morphine-treated rats.
Topics: Animals; Body Temperature; Cocaine; Diazepam; Drug Interactions; Humans; Male; Morphine; Morphine Dependence; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Temperature; Time Factors | 1982 |
Systems of reinforcement and drug dependence.
Topics: Amphetamines; Animals; Cats; Chlordiazepoxide; Cocaine; Diazepam; Drug Tolerance; Escape Reaction; Ethanol; Heroin; Humans; Morphine; Pentobarbital; Psychophysiology; Rats; Reinforcement, Psychology; Substance Withdrawal Syndrome; Substance-Related Disorders | 1982 |
[Neuropharmacological studies on drug dependence (II). Changes in spontaneous motor activity, EEG and brain monoamines during the period of dependence development and of abrupt withdrawal in rats, with special reference to circadian rhythm (author's trans
Topics: Animals; Biogenic Amines; Brain; Circadian Rhythm; Cocaine; Diazepam; Electroencephalography; Humans; Male; Methamphetamine; Morphine Dependence; Motor Activity; Opioid-Related Disorders; Phenobarbital; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1980 |
Locomotor activity in morphine-treated rats: effects of and comparisons between cocaine, procaine, and lidocaine.
Topics: Animals; Cocaine; Humans; Lidocaine; Male; Morphine; Morphine Dependence; Motor Activity; Procaine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1981 |
Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Behavior, Animal; Cocaine; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Substance Withdrawal Syndrome; Synapses | 1995 |
Craving in hospitalized cocaine abusers as a predictor of outcome.
Topics: Adult; Cocaine; Female; Follow-Up Studies; Humans; Length of Stay; Male; Motivation; Neurologic Examination; Patient Admission; Recurrence; Risk Factors; Social Environment; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome | 1995 |
Evidence for alterations in presynaptic serotonergic function during withdrawal from chronic cocaine in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Cocaine; Corticosterone; Fenfluramine; Humans; Male; Neurosecretory Systems; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Substance Withdrawal Syndrome | 1995 |
Rat brain neurotransmitter turnover rates altered during withdrawal from chronic cocaine administration.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Brain Chemistry; Cocaine; Conditioning, Operant; Injections, Intravenous; Kinetics; Male; Narcotics; Neurons; Neurotransmitter Agents; Rats; Rats, Inbred F344; Self Administration; Substance Withdrawal Syndrome | 1995 |
Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine.
Topics: Animals; Biological Transport; Cocaine; Dialysis; Dopamine; Dopamine Uptake Inhibitors; Infusions, Intravenous; Male; Narcotics; Nucleus Accumbens; Rats; Rats, Wistar; Self Administration; Serotonin; Substance Withdrawal Syndrome | 1995 |
Tolerance-like attenuation to contingent and noncontingent cocaine-induced elevation of extracellular dopamine in the ventral striatum following 7 days of withdrawal from chronic treatment.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine; Drug Tolerance; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Time Factors | 1995 |
An examination of the cocaine relapse process.
Topics: Adult; Affect; Arousal; Cocaine; Female; Follow-Up Studies; Humans; Internal-External Control; Male; Personality Assessment; Psychometrics; Recurrence; Risk Factors; Social Environment; Social Support; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome | 1995 |
Brain corticotropin-releasing factor mediates 'anxiety-like' behavior induced by cocaine withdrawal in rats.
Topics: Animals; Anxiety; Behavior, Animal; Brain Chemistry; Cocaine; Corticotropin-Releasing Hormone; Injections, Intraperitoneal; Injections, Intraventricular; Male; Radioimmunoassay; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1995 |
Neuropsychological performance of recently abstinent alcoholics and cocaine abusers.
Topics: Adult; Alcoholism; Cocaine; Ethanol; Female; Humans; Intelligence; Male; Mental Recall; Middle Aged; Neuropsychological Tests; Pattern Recognition, Visual; Problem Solving; Psychomotor Performance; Reaction Time; Substance Withdrawal Syndrome; Substance-Related Disorders; Verbal Learning | 1995 |
Dissociation of "conscious desire" (craving) from and relapse in alcohol and cocaine dependence.
Topics: Adult; Alcoholism; Awareness; Cocaine; Diagnosis, Dual (Psychiatry); Ethanol; Female; Follow-Up Studies; Humans; Male; Middle Aged; Motivation; Recurrence; Rehabilitation Centers; Risk Factors; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome | 1994 |
Regulation of cytochrome c oxidase subunit mRNA and enzyme activity in rat brain reward regions during withdrawal from chronic cocaine.
Topics: Animals; Brain; Caudate Nucleus; Cocaine; Electron Transport Complex IV; Isoenzymes; Male; Nucleus Accumbens; Prefrontal Cortex; Putamen; Rats; Rats, Sprague-Dawley; Reward; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors | 1995 |
Persistent reduction of immediate early gene mRNA in rat forebrain following single or multiple doses of cocaine.
Topics: Animals; Cocaine; DNA-Binding Proteins; Drug Administration Schedule; Early Growth Response Protein 1; Gene Expression; Genes, fos; Genes, Immediate-Early; Immediate-Early Proteins; Injections, Intraperitoneal; Injections, Intravenous; Male; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome; Transcription Factors; Zinc Fingers | 1994 |
Quantitative EEG changes in cocaine withdrawal: evidence for long-term CNS effects.
Topics: Adolescent; Adult; Alpha Rhythm; Beta Rhythm; Brain; Cocaine; Delta Rhythm; Electroencephalography; Female; Follow-Up Studies; Humans; Male; Substance Withdrawal Syndrome; Theta Rhythm | 1994 |
Beta-adrenergic antagonists attenuate withdrawal anxiety in cocaine- and morphine-dependent rats.
Topics: Adrenergic beta-Antagonists; Animals; Anxiety; Atenolol; Cocaine; Injections, Intraperitoneal; Male; Morphine Dependence; Propranolol; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Dopamine efflux during withdrawal from continuous or intermittent cocaine.
Topics: Animals; Caudate Nucleus; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Extracellular Space; In Vitro Techniques; Infusion Pumps, Implantable; Male; Putamen; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1993 |
Continuous or intermittent cocaine administration: effects of flupenthixol treatment during withdrawal.
Topics: Animals; Behavior, Animal; Cocaine; Drug Tolerance; Flupenthixol; Infusion Pumps, Implantable; Male; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1994 |
Withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in the nucleus accumbens of Lewis rats.
Topics: Animals; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nucleus Accumbens; Rats; Rats, Inbred Lew; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase | 1994 |
The striatal transporter for dopamine in the rat may be kinetically up-regulated following 3 weeks of withdrawal from cocaine self-administration.
Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Reference Values; Self Administration; Substance Withdrawal Syndrome; Time Factors | 1994 |
Effects of dopamine on prolactin: interactions with cocaine self-administration by female rhesus monkeys.
Topics: Animals; Cocaine; Dopamine; Female; Macaca mulatta; Prolactin; Self Administration; Substance Withdrawal Syndrome | 1994 |
Electroencephalographic activity and mood in cocaine-dependent outpatients: effects of cocaine cue exposure.
Topics: Adolescent; Adult; Affect; Arousal; Cerebral Cortex; Cocaine; Cues; Electroencephalography; Evoked Potentials; Humans; Male; Middle Aged; Personality Inventory; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Should tolerance and withdrawal be required for substance dependence disorders?
Topics: Adolescent; Adult; Alcoholism; Ambulatory Care; Cocaine; Drug Tolerance; Female; Humans; Illicit Drugs; Male; Middle Aged; Opioid-Related Disorders; Psychiatric Status Rating Scales; Psychotropic Drugs; Risk Factors; Social Adjustment; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Cocaine craving.
Topics: Adolescent; Amitriptyline; Cocaine; Desipramine; Humans; Hypotension, Orthostatic; Male; Risk Factors; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Behavioural consequences of cocaine withdrawal in rats.
Topics: Animals; Anxiety; Behavior, Animal; Cocaine; Eating; Male; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1994 |
Lisuride reduces intravenous cocaine self-administration in rats.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Injections, Intravenous; Lisuride; Male; Motor Activity; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Peripheral benzodiazepine receptors are decreased during cocaine withdrawal in humans.
Topics: Adult; Cocaine; Homovanillic Acid; Humans; Kinetics; Male; Middle Aged; Neutrophils; Radioligand Assay; Receptors, GABA-A; Substance Withdrawal Syndrome | 1994 |
Saccadic distractibility in cocaine dependent patients: a preliminary laboratory exploration of the cocaine-OCD hypothesis.
Topics: Adult; Attention; Cocaine; Female; Humans; Male; Motivation; Obsessive-Compulsive Disorder; Risk Factors; Saccades; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Lack of altered startle responding in rats following termination of self-administered or noncontingently infused cocaine.
Topics: Acoustic Stimulation; Animals; Cocaine; Infusions, Intravenous; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reflex, Startle; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Behavioral pharmacology of tandospirone in baboons: chronic administration and withdrawal, self-injection and drug discrimination.
Topics: Animals; Anti-Anxiety Agents; Arousal; Buspirone; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Eating; Flumazenil; Isoindoles; Lorazepam; Male; Motor Skills; Neurologic Examination; Papio; Pentobarbital; Piperazines; Pyrimidines; Reinforcement Schedule; Self Administration; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Time-dependent changes in sensitivity to apomorphine and monoamine receptors following withdrawal from continuous cocaine administration in rats.
Topics: Animals; Apomorphine; Autoradiography; Behavior, Animal; Brain; Cocaine; Male; Motor Activity; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Serotonin; Stereotyped Behavior; Substance Withdrawal Syndrome; Time Factors | 1994 |
The development of a cocaine craving questionnaire.
Topics: Adult; Cocaine; Factor Analysis, Statistical; Female; Humans; Male; Neurologic Examination; Personality Inventory; Psychometrics; Reproducibility of Results; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Heterogeneous subregional binding patterns of 3H-WIN 35,428 and 3H-GBR 12,935 are differentially regulated by chronic cocaine self-administration.
Topics: Animals; Biogenic Monoamines; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Rats; Rats, Wistar; Reference Values; Self Administration; Substance Withdrawal Syndrome; Time Factors; Tissue Distribution; Tritium | 1994 |
Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function.
Topics: Animals; Apomorphine; Behavior, Animal; Cocaine; Corpus Striatum; Dopamine; Electric Stimulation; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger; Substance Withdrawal Syndrome | 1994 |
The acute effects of a rapid medical detoxification upon dysphoria and other psychopathology experienced by heroin abusers.
Topics: Adult; Cocaine; Comorbidity; Depressive Disorder; Heroin Dependence; Hospitalization; Humans; Male; Methadone; Personality Disorders; Personality Inventory; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cocaine; Dopamine; Hypothalamus; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1994 |
5-HT3 receptor modulation of behavior during withdrawal from continuous or intermittent cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Infusions, Intravenous; Male; Motor Activity; Ondansetron; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Stereotyped Behavior; Substance Withdrawal Syndrome | 1994 |
Continuous or intermittent cocaine administration: effects of amantadine treatment during withdrawal.
Topics: Amantadine; Animals; Behavior, Animal; Cocaine; Drug Tolerance; Male; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1994 |
Elevated serum CK in long abstinent cocaine abusers.
Topics: Adult; Cocaine; Creatine Kinase; Humans; Jogging; Male; Middle Aged; Muscles; Reference Values; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Suppression of opiate withdrawal and cocaine hyperarousal syndromes by buspirone. Possible pharmacotherapeutic applications.
Topics: Animals; Arousal; Buspirone; Cocaine; Female; Macaca mulatta; Male; Morphine; Rats; Stereotyped Behavior; Substance Withdrawal Syndrome | 1993 |
The effects of dose and access restrictions on the periodicity of cocaine self-administration in the rat.
Topics: Animals; Circadian Rhythm; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Motivation; Periodicity; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Subjective reports of withdrawal among cocaine users: recommendations for DSM-IV.
Topics: Adult; Arousal; Cocaine; Female; Humans; Illicit Drugs; Male; Narcotics; Neurologic Examination; Opioid-Related Disorders; Psychiatric Status Rating Scales; Psychotropic Drugs; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Effects of cocaine self-administration on ethanol, food and water intake in the rat.
Topics: Alcohol Drinking; Animals; Cocaine; Dose-Response Relationship, Drug; Drinking; Eating; Infusions, Intravenous; Male; Motivation; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 1993 |
Dopamine and serotonin release-regulating autoreceptor sensitivity in A9/A10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Corpus Striatum; Dopamine; Drug Tolerance; Infusion Pumps, Implantable; Male; Mesencephalon; Motor Activity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Substance Withdrawal Syndrome; Tritium | 1993 |
Withdrawal from chronic cocaine enhances behavioral sensitivity to the 5-HT2/1C agonist DOI.
Topics: Amphetamines; Animals; Behavior, Animal; Brain; Cocaine; Humans; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists; Stereotyped Behavior; Substance Withdrawal Syndrome | 1993 |
Withdrawal from continuous or intermittent cocaine: behavioral responsivity to 5-HT1 receptor agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Cocaine; Drug Tolerance; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists; Substance Withdrawal Syndrome | 1993 |
Cocaine dependence: alcohol and other drug dependence and withdrawal characteristics.
Topics: Adolescent; Adult; Alcohol Withdrawal Delirium; Alcoholism; Cocaine; Comorbidity; Female; Humans; Male; Middle Aged; Neurologic Examination; Psychotherapy, Group; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders; United States | 1993 |
Daily cocaine craving in a 3-week inpatient treatment program.
Topics: Adult; Cocaine; Humans; Male; Neurologic Examination; Psychometrics; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders; Veterans | 1993 |
Reaction time during cocaine versus alcohol withdrawal: longitudinal measures of visual and auditory suppression.
Topics: Acoustic Stimulation; Adult; Alcoholism; Attention; Cocaine; Discrimination Learning; Ethanol; Female; Humans; Longitudinal Studies; Male; Photic Stimulation; Psychomotor Performance; Reaction Time; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Neuropsychological deficits in abstinent cocaine abusers: preliminary findings after two weeks of abstinence.
Topics: Adult; Cocaine; Concept Formation; Female; Humans; Male; Mental Recall; Neuropsychological Tests; Pattern Recognition, Visual; Problem Solving; Psychomotor Performance; Reaction Time; Substance Abuse Detection; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Extrapyramidal symptoms and cocaine abuse.
Topics: Adult; Basal Ganglia Diseases; Cocaine; Humans; Male; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Withdrawal from continuous or intermittent cocaine: effects of NAN-190 on cocaine-induced locomotion.
Topics: Analysis of Variance; Animals; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Sensitivity and Specificity; Serotonin Antagonists; Substance Withdrawal Syndrome | 1993 |
1990-1991 survey of pharmacotherapies used in the treatment of cocaine abuse.
Topics: Attitude of Health Personnel; Cocaine; Humans; Psychotropic Drugs; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Withdrawal following cocaine self-administration decreases regional cerebral metabolic rate in critical brain reward regions.
Topics: Animals; Autoradiography; Brain; Cocaine; Deoxyglucose; Male; Rats; Rats, Wistar; Reward; Self Administration; Substance Withdrawal Syndrome; Time Factors; Tissue Distribution | 1993 |
Measures of visual scanning as a predictor of cocaine cravings and urges.
Topics: Adult; Attention; Cocaine; Female; Humans; Male; Motivation; Pattern Recognition, Visual; Reaction Time; Saccades; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Reduced clearance of exogenous dopamine in rat nucleus accumbens, but not in dorsal striatum, following cocaine challenge in rats withdrawn from repeated cocaine administration.
Topics: Animals; Autoradiography; Behavior, Animal; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Electrochemistry; Male; Mazindol; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1993 |
Cocaine levels in striatum and nucleus accumbens: augmentation following challenge injection in rats withdrawn from repeated cocaine administration.
Topics: Animals; Cocaine; Corpus Striatum; Drug Administration Schedule; Injections, Intraperitoneal; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1993 |
Motoric signs of CNS dysfunction associated with alcohol and cocaine withdrawal.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Cerebellar Ataxia; Cocaine; Female; Humans; Male; Neurologic Examination; Parkinson Disease, Secondary; Postural Balance; Substance Withdrawal Syndrome; Substance-Related Disorders; Tremor | 1993 |
Quantitative electroencephalographic analyses in cocaine-preferring polysubstance abusers during abstinence.
Topics: Adult; Alcoholism; Brain Mapping; Cerebral Cortex; Cocaine; Electroencephalography; Female; Humans; Illicit Drugs; Male; Marijuana Abuse; Middle Aged; Psychotropic Drugs; Signal Processing, Computer-Assisted; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Phenomenology and neurobiology of cocaine withdrawal: are they related?
Topics: Adult; Affect; Binding, Competitive; Cocaine; Female; Humans; Imipramine; Male; Psychiatric Status Rating Scales; Radioligand Assay; Substance Withdrawal Syndrome | 1995 |
Abnormal cerebral metabolism in polydrug abusers during early withdrawal: a 31P MR spectroscopy study.
Topics: Adult; Brain; Case-Control Studies; Cocaine; Heroin Dependence; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methadone; Phosphates; Phospholipids; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1996 |
Altered dopamine transporter densities in alcohol-preferring vervet monkeys.
Topics: Alcohol Drinking; Animals; Autoradiography; Brain Chemistry; Carrier Proteins; Central Nervous System Depressants; Chlorocebus aethiops; Cocaine; Dopamine Plasma Membrane Transport Proteins; Ethanol; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phenotype; Substance Withdrawal Syndrome | 1996 |
Abnormal electroretinogram in cocaine-dependent patients. Relationship to craving.
Topics: Adult; Arousal; Cocaine; Electroretinography; Female; Humans; Male; Middle Aged; Motivation; Reference Values; Retinal Cone Photoreceptor Cells; Substance Withdrawal Syndrome; Substance-Related Disorders | 1996 |
Polygraphic sleep measures differentiate alcoholics and stimulant abusers during short-term abstinence.
Topics: Acute Disease; Adult; Alcoholism; Amphetamine; Cocaine; Ethanol; Humans; Illicit Drugs; Male; Middle Aged; Neurologic Examination; Polysomnography; Sleep, REM; Substance Withdrawal Syndrome | 1995 |
Alteration of brain dopamine and serotonin levels in cocaine users: a preliminary report.
Topics: Adult; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dopamine; Frontal Lobe; Humans; Serotonin; Substance Withdrawal Syndrome; Substance-Related Disorders | 1996 |
Chronic cocaine exposure potentiates prolactin and head shake responses to 5-HT2 receptor stimulation in rats.
Topics: Amphetamines; Animals; Cocaine; Dose-Response Relationship, Drug; Male; Narcotics; Prolactin; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Stereotyped Behavior; Substance Withdrawal Syndrome | 1996 |
Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration.
Topics: Animals; Cocaine; Extracellular Space; Male; Microdialysis; Narcotics; Nucleus Accumbens; Rats; Rats, Wistar; Self Administration; Serotonin; Substance Withdrawal Syndrome; Synaptic Transmission | 1996 |
Changes in behavioral sensitivity to SKF-38393 and quinpirole following withdrawal from continuous cocaine administration in rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Cocaine; Dopamine Agonists; Ergolines; Male; Motor Activity; Narcotics; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior; Substance Withdrawal Syndrome | 1996 |
Cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens.
Topics: Animals; Autoradiography; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Image Processing, Computer-Assisted; Male; Membrane Glycoproteins; Membrane Transport Proteins; Narcotics; Neostriatum; Nerve Tissue Proteins; Nucleus Accumbens; Olfactory Bulb; Rats; Rats, Inbred Lew; Substance Withdrawal Syndrome; Ventral Tegmental Area | 1996 |
Withdrawal from oral cocaine in rate: ultrasonic vocalizations and tactile startle.
Topics: Animals; Cocaine; Male; Narcotics; Rats; Reflex, Startle; Self Administration; Substance Withdrawal Syndrome; Time Factors; Vocalization, Animal | 1996 |
Abstinence symptomatology associated with cessation of chronic cocaine abuse among methadone-maintained patients.
Topics: Adult; Chronic Disease; Cocaine; Ethanol; Female; Humans; Male; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1996 |
Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving.
Topics: Adult; Analgesics, Opioid; Brain; Cocaine; Female; Fentanyl; Humans; Male; Opioid-Related Disorders; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Time Factors; Tomography, Emission-Computed | 1996 |
Sensitization of neuronal response to cocaine during withdrawal following chronic treatment.
Topics: Animals; Autoradiography; Cerebral Cortex; Cocaine; DNA-Binding Proteins; Early Growth Response Protein 1; Immediate-Early Proteins; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sensitivity and Specificity; Substance Withdrawal Syndrome; Time Factors; Transcription Factors | 1996 |
Changes in serotonin and norepinephrine uptake sites after chronic cocaine: pre- vs. post-withdrawal effects.
Topics: Administration, Oral; Animals; Autoradiography; Biological Transport; Brain; Carrier Proteins; Cocaine; Drug Administration Schedule; Female; Fluoxetine; Imipramine; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Substance Withdrawal Syndrome; Substance-Related Disorders; Symporters; Time Factors; Tritium | 1996 |
Repeated cocaine exposure attenuates the ability of 5-hydroxytryptamine to release striatal dopamine in vivo.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Substance Withdrawal Syndrome | 1996 |
Longitudinal study of blue cone retinal function in cocaine-withdrawn patients.
Topics: Adult; Cocaine; Electroretinography; Humans; Longitudinal Studies; Male; Middle Aged; Opioid-Related Disorders; Retinal Cone Photoreceptor Cells; Substance Withdrawal Syndrome | 1997 |
Differential effects of SCH 23390 on the apomorphine subsensitivity in the substantia nigra and ventral tegmental area 1 day following withdrawal from continuous or intermittent cocaine pretreatment.
Topics: Animals; Apomorphine; Benzazepines; Cocaine; Male; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substantia Nigra; Tegmentum Mesencephali | 1997 |
Reduced blue cone electroretinogram in cocaine-withdrawn patients.
Topics: Adult; Cocaine; Color Perception; Dopamine; Electroretinography; Humans; Opioid-Related Disorders; Retinal Cone Photoreceptor Cells; Substance Withdrawal Syndrome | 1997 |
Regional binding to corticotropin releasing factor receptors in brain of rats exposed to chronic cocaine and cocaine withdrawal.
Topics: Animals; Brain; Cocaine; Drug Administration Schedule; Infusions, Intravenous; Male; Radioligand Assay; Rats; Rats, Inbred Lew; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome | 1997 |
Antisocial personality disorder and aggression in recently abstinent cocaine dependent subjects.
Topics: Adult; Aggression; Antisocial Personality Disorder; Cocaine; Female; Humans; Male; Personality Assessment; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Quantitation of dopamine transporter mRNA in the rat brain: mapping, effects of "binge" cocaine administration and withdrawal.
Topics: Animals; Blotting, Northern; Brain; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Inbred F344; RNA, Messenger; Substance Withdrawal Syndrome | 1997 |
Blockade of cocaine sensitization and tolerance by the co-administration of ondansetron, a 5-HT3 receptor antagonist, and cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Injections, Subcutaneous; Male; Narcotic Antagonists; Narcotics; Ondansetron; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Substance Withdrawal Syndrome | 1997 |
Neurophysiological signs of cocaine dependence: increased electroencephalogram beta during withdrawal.
Topics: Adult; Beta Rhythm; Cocaine; Electroencephalography; Humans; Male; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
5-HT3 receptor mediated dopamine release in the nucleus accumbens during withdrawal from continuous cocaine.
Topics: Animals; Biguanides; Cocaine; Dopamine; Male; Narcotics; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Substance Withdrawal Syndrome | 1997 |
Risperidone and neuropsychological test performance in cocaine-withdrawn patients.
Topics: Adult; Antipsychotic Agents; Cocaine; Humans; Male; Neuropsychological Tests; Risperidone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Event-related potential changes in cocaine withdrawal: evidence for long-term cognitive effects.
Topics: Adolescent; Adult; Cocaine; Cognition; Event-Related Potentials, P300; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuropsychological Tests; Reaction Time; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Effects of short- and long-term withdrawal from gestational cocaine treatment on maternal behavior and aggression in Sprague-Dawley rats.
Topics: Aggression; Animals; Cocaine; Female; Maternal Behavior; Narcotics; Pregnancy; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1997 |
Quantitative electroencephalographic differences associated with alcohol, cocaine, heroin and dual-substance dependence.
Topics: Adult; Alcoholism; Antisocial Personality Disorder; Beta Rhythm; Cerebral Cortex; Cocaine; Comorbidity; Diagnosis, Dual (Psychiatry); Electroencephalography; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Signal Processing, Computer-Assisted; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Physiological and subjective effects of acute cocaine withdrawal (crash) in rats.
Topics: Animals; Body Temperature; Cocaine; Discrimination Learning; Electroencephalography; Haloperidol; Individuality; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Motor Activity; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Time Factors | 1997 |
Impaired color vision in cocaine-withdrawn patients.
Topics: Adult; Cocaine; Color Perception; Color Perception Tests; Color Vision Defects; Electroretinography; Female; Hospitalization; Humans; Male; Middle Aged; Retina; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Withdrawal from chronic cocaine administration causes prolonged deficits in L-tryptophan-induced head-twitch response in mice.
Topics: Analysis of Variance; Animals; Cocaine; Drug Administration Schedule; Male; Mice; Mice, Inbred ICR; Monoamine Oxidase Inhibitors; Motor Activity; Opioid-Related Disorders; Serotonin; Stereotyped Behavior; Substance Withdrawal Syndrome; Time Factors; Tranylcypromine; Tryptophan | 1997 |
Regional differences in rat brain dopamine transporter binding: function of time after chronic cocaine.
Topics: Animals; Brain; Brain Chemistry; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Narcotics; Neostriatum; Nerve Tissue Proteins; Piperazines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1993 |
Multiplex differential display identifies a novel zinc-finger protein repressed during withdrawal from cocaine.
Topics: Amino Acid Sequence; Animals; Caudate Nucleus; Cocaine; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression Regulation; Immediate-Early Proteins; Male; Mice; Polymerase Chain Reaction; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Sprague-Dawley; Sequence Alignment; Sequence Homology, Amino Acid; Substance Withdrawal Syndrome; Time Factors; Transcription Factors; Zinc Fingers | 1997 |
Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Benzazepines; Cocaine; Cocaine-Related Disorders; Cyclic AMP-Dependent Protein Kinases; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Electric Conductivity; Male; Membrane Potentials; Neuronal Plasticity; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Sodium Channels; Substance Withdrawal Syndrome | 1998 |
Deficits in D-fenfluramine-sensitive pool of brain 5-HT following withdrawal from chronic cocaine exposure.
Topics: Animals; Brain; Cocaine; Fenfluramine; Head Movements; Kinetics; Male; Mice; Mice, Inbred ICR; Serotonin; Serotonin Agents; Substance Withdrawal Syndrome | 1997 |
Increased motor response to cocaine administration following recovery from chronic corticosterone treatment in the rat.
Topics: Animals; Cocaine; Corticosterone; Dopamine Uptake Inhibitors; Male; Motor Activity; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1998 |
Alterations in baseline activity and quinpirole sensitivity in putative dopamine neurons in the substantia nigra and ventral tegmental area after withdrawal from cocaine pretreatment.
Topics: Animals; Cocaine; Dopamine Agonists; Electrophysiology; Male; Narcotics; Neurons; Quinpirole; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substantia Nigra; Ventral Tegmental Area | 1998 |
Withdrawal from i.v. cocaine "binges" in rats: ultrasonic distress calls and startle.
Topics: Animals; Cocaine; Injections, Intravenous; Male; Rats; Reflex, Startle; Self Administration; Substance Withdrawal Syndrome; Vocalization, Animal | 1998 |
Blockade of the expression of sensitization and tolerance by ondansetron, a 5-HT3 receptor antagonist, administered during withdrawal from intermittent and continuous cocaine.
Topics: Animals; Cocaine; Drug Tolerance; Male; Models, Psychological; Narcotics; Ondansetron; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Substance Withdrawal Syndrome | 1998 |
Prolonged deficits in presynaptic serotonin function following withdrawal from chronic cocaine exposure as revealed by 5-HTP-induced head-twitch response in mice.
Topics: 5-Hydroxytryptophan; Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Head Movements; Male; Mice; Mice, Inbred ICR; Receptors, Presynaptic; Serotonin; Substance Withdrawal Syndrome | 1997 |
Stress-induced cross-sensitization to cocaine: effect of adrenalectomy and corticosterone after short- and long-term withdrawal.
Topics: Adrenalectomy; Animals; Cocaine; Corticosterone; Dopamine Uptake Inhibitors; Environment; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Stress, Psychological; Substance Withdrawal Syndrome | 1998 |
Withdrawal from a self-administered or non-contingent cocaine binge: differences in ultrasonic distress vocalizations in rats.
Topics: Animals; Cocaine; Male; Narcotics; Rats; Reflex, Startle; Self Administration; Substance Withdrawal Syndrome; Vocalization, Animal | 1998 |
Specific reductions of striatal prodynorphin and D1 dopamine receptor messenger RNAs during cocaine abstinence.
Topics: Animals; Cocaine; Corpus Striatum; Enkephalins; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Substance Withdrawal Syndrome | 1998 |
Time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal.
Topics: Amygdala; Animals; Cocaine; Cocaine-Related Disorders; Cues; Dopamine; Extracellular Space; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 1998 |
Sustained withdrawal allows normalization of in vivo [11C]N-methylspiperone dopamine D2 receptor binding after chronic binge cocaine: a positron emission tomography study in rats.
Topics: Analysis of Variance; Animals; Benzazepines; Brain; Carbon Radioisotopes; Cocaine; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Spiperone; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Tomography, Emission-Computed | 1998 |
Transient amelioration of the sensitization of cocaine-induced behaviors in rats by the induction of tolerance.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Tolerance; Humans; Infant; Male; Osmotic Pressure; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substance Withdrawal Syndrome; Substance-Related Disorders | 1998 |
Regional cerebral blood flow during acute and chronic abstinence from combined cocaine-alcohol abuse.
Topics: Adult; Brain; Case-Control Studies; Central Nervous System Depressants; Central Nervous System Stimulants; Cerebrovascular Circulation; Cocaine; Drug Interactions; Ethanol; Female; Frontal Lobe; Humans; Longitudinal Studies; Male; Parietal Lobe; Remission, Spontaneous; Single-Blind Method; Substance Withdrawal Syndrome; Temperance; Time Factors; Tomography, Emission-Computed, Single-Photon; Vasoconstrictor Agents | 1998 |
Modification of cataleptic responses to dopamine receptor antagonists after withdrawal from chronic cocaine or cocaine plus dopamine antagonist administration.
Topics: Animals; Antipsychotic Agents; Catalepsy; Cocaine; Dopamine Agonists; Dopamine Uptake Inhibitors; Haloperidol; Male; Mice; Receptors, Dopamine D1; Receptors, Dopamine D2; Substance Withdrawal Syndrome | 1998 |
Altered cocaine potency in the nucleus accumbens following 7-day withdrawal from intermittent but not continuous treatment: voltammetric assessment of dopamine uptake in the rat.
Topics: Animals; Cocaine; Culture Techniques; Dopamine; Male; Membrane Potentials; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1998 |
Decreased presynaptic sensitivity to adenosine after cocaine withdrawal.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Affinity Labels; Animals; Cocaine; Dipyridamole; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Male; Nucleus Accumbens; Phosphodiesterase Inhibitors; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline; Thioinosine; Vasodilator Agents; Xanthines | 1998 |
Alterations in serotonergic responsiveness during cocaine withdrawal in rats: similarities to major depression in humans.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Cocaine; Depressive Disorder; Dopamine Uptake Inhibitors; Feeding Behavior; Fenfluramine; Male; Prolactin; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists; Substance Withdrawal Syndrome | 1998 |
Dopamine and the P50.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Evoked Potentials, Auditory; Humans; Rats; Substance Withdrawal Syndrome | 1998 |
Cigarette smoking during early cocaine abstinence.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Female; Humans; Male; Narcotics; Smoking; Substance Withdrawal Syndrome | 1998 |
Reduced central serotonin transporters in alcoholism.
Topics: Adult; Alcohol Drinking; Alcoholism; Anxiety Disorders; Brain Stem; Carrier Proteins; Cocaine; Depressive Disorder; Dopamine; Dopamine Plasma Membrane Transport Proteins; Ethanol; Humans; Iodine Radioisotopes; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Recurrence; Risk Factors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Substance Withdrawal Syndrome; Tomography, Emission-Computed, Single-Photon | 1998 |
Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine.
Topics: Animals; Cocaine; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Electron; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Synaptic Vesicles; Time Factors | 1998 |
Smoked cocaine self-administration in females and voucher incentives for abstinence.
Topics: Adult; Arousal; Cocaine; Cocaine-Related Disorders; Female; Humans; Motivation; Patient Compliance; Prolactin; Self Administration; Substance Abuse Detection; Substance Withdrawal Syndrome; Token Economy | 1998 |
Acquisition, maintenance and reinstatement of intravenous cocaine self-administration under a second-order schedule of reinforcement in rats: effects of conditioned cues and continuous access to cocaine.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Male; Rats; Reinforcement, Psychology; Substance Abuse, Intravenous; Substance Withdrawal Syndrome | 1998 |
Effects of ethanol hangover on the operant self-administration of cocaine in rats.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Ethanol; Male; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome | 1999 |
Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat.
Topics: Analysis of Variance; Animals; Cocaine; Dopamine Antagonists; Flupenthixol; Male; Motor Activity; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome; Time Factors | 1999 |
Early withdrawal from repeated cocaine administration upregulates muscarinic and dopaminergic D2-like receptors in rat neostriatum.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Female; Motor Activity; Neostriatum; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Muscarinic; Substance Withdrawal Syndrome; Up-Regulation | 1999 |
A heroin-, but not a cocaine-expecting, self-administration state preferentially alters endogenous brain peptides.
Topics: Animals; Behavior, Animal; Brain; Cocaine; Dynorphins; Enkephalins; Heroin; Injections, Intravenous; Male; Neuropeptides; Radioimmunoassay; Rats; Rats, Wistar; Self Administration; Substance P; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1999 |
Cocaine abstinence symptomatology and treatment attrition.
Topics: Ambulatory Care; Cocaine; Cocaine-Related Disorders; Confidence Intervals; Counseling; Female; Humans; Logistic Models; Male; Patient Dropouts; Probability; Psychotherapy, Group; Regression Analysis; Sensitivity and Specificity; Severity of Illness Index; Substance Abuse Detection; Substance Withdrawal Syndrome; Treatment Outcome | 1999 |
Cocaine withdrawal and the cerebral influx of [18F]fluoro-L-DOPA (FDOPA)
Topics: Brain Chemistry; Cocaine; Dihydroxyphenylalanine; Dopamine Uptake Inhibitors; Fluorine Radioisotopes; Humans; Substance Withdrawal Syndrome | 1999 |
Dopamine transporters increase in human brain after alcohol withdrawal.
Topics: Adult; Aged; Alcoholism; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Iodine Radioisotopes; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Reference Values; Substance Withdrawal Syndrome; Temperance; Time Factors; Tomography, Emission-Computed, Single-Photon | 1999 |
Sensitization to the locomotor stimulant effect of cocaine modifies the binding of [3H]MK-801 to brain regions and spinal cord of the mouse.
Topics: Animals; Brain; Cocaine; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Mice; Motor Activity; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance Withdrawal Syndrome; Tritium | 1999 |
Reciprocal changes in dopamine responsiveness in the nucleus accumbens shell and core and in the dorsal caudate-putamen in rats sensitized to morphine.
Topics: Amphetamine; Animals; Catalepsy; Caudate Nucleus; Cocaine; Dopamine; Drug Interactions; Grooming; Male; Microdialysis; Morphine; Morphine Dependence; Motor Activity; Nucleus Accumbens; Putamen; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substance Withdrawal Syndrome | 1999 |
Cocaine babies: hooked at birth.
Topics: Cocaine; Humans; Infant, Newborn; Nurseries, Hospital; Substance Withdrawal Syndrome; United States | 1986 |
In vivo CRF release in rat amygdala is increased during cocaine withdrawal in self-administering rats.
Topics: Amygdala; Animals; Cocaine; Corticotropin-Releasing Hormone; Male; Narcotics; Rats; Rats, Wistar; Self Administration; Substance Abuse, Intravenous; Substance Withdrawal Syndrome | 1999 |
Dopaminergic mechanisms mediating the incentive to seek cocaine and heroin following long-term withdrawal of IV drug self-administration.
Topics: Animals; Behavior, Addictive; Benzazepines; Cocaine; Dopamine Agonists; Dopamine Uptake Inhibitors; Heroin; Male; Narcotics; Piperazines; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine; Substance Withdrawal Syndrome | 1999 |
Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Cocaine; Corticotropin-Releasing Hormone; Illicit Drugs; Male; Peptide Fragments; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1999 |
Neurotrophin-3 contributes to the initiation of behavioral sensitization to cocaine by activating the Ras/Mitogen-activated protein kinase signal transduction cascade.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cocaine; Drug Interactions; Enzyme Inhibitors; Flavonoids; Hippocampus; Male; Microinjections; Mitogen-Activated Protein Kinase Kinases; Nerve Growth Factors; Neurotrophin 3; Protein Kinase Inhibitors; ras Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Stereotyped Behavior; Substance Withdrawal Syndrome; Substantia Nigra; Tegmentum Mesencephali; Transcription, Genetic | 1999 |
Long-term changes in connexin32 gap junction protein and mRNA expression following cocaine self-administration in rats.
Topics: Animals; Antibody Specificity; Blotting, Western; Cocaine; Connexins; Dopamine Uptake Inhibitors; Enzyme-Linked Immunosorbent Assay; Epilepsy; Gap Junction beta-1 Protein; Gap Junctions; Hippocampus; Immunohistochemistry; In Situ Hybridization; Injections; Male; Neostriatum; Nucleus Accumbens; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Self Administration; Substance Withdrawal Syndrome | 1999 |
Cocaine-induced cardiovascular responses in rats during acute ethanol withdrawal.
Topics: Animals; Central Nervous System Depressants; Cocaine; Dose-Response Relationship, Drug; Ethanol; Heart Rate; Hemodynamics; Male; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Vasoconstrictor Agents | 1999 |
Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats.
Topics: Adenosine; Animals; Brain; Caffeine; Cocaine; Differential Threshold; Dopamine Uptake Inhibitors; Drug Interactions; Electric Stimulation; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Reaction Time; Receptors, Purinergic P1; Reference Values; Reward; Substance Withdrawal Syndrome; Theobromine | 1999 |
Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal.
Topics: Animals; Caudate Nucleus; Cocaine; Dopamine; Electric Stimulation; In Vitro Techniques; Male; Neurons; Nucleus Accumbens; Presynaptic Terminals; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Substance Withdrawal Syndrome; Substantia Nigra; Ventral Tegmental Area | 2000 |
Enhanced accumbal dopamine release following 5-HT(2A) receptor stimulation in rats pretreated with intermittent cocaine.
Topics: Amphetamines; Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Ketanserin; Male; Microdialysis; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Time Factors | 2000 |
Factors that determine a propensity for cocaine-seeking behavior during abstinence in rats.
Topics: Amphetamine; Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Locomotion; Male; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reaction Time; Reward; Self Administration; Substance Withdrawal Syndrome | 2000 |
A rodent model of cocaine abstinence syndrome.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Humans; Infant, Newborn; Infusion Pumps, Implantable; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Syndrome | 2000 |
Autoradiographic evidence that prolonged withdrawal from intermittent cocaine reduces mu-opioid receptor expression in limbic regions of the rat brain.
Topics: Analgesics, Opioid; Animals; Autoradiography; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Iodine Radioisotopes; Limbic System; Male; Nucleus Accumbens; Rats; Rats, Inbred Lew; Receptors, Opioid, mu; Septal Nuclei; Substance Withdrawal Syndrome | 2000 |
Skin conductance hypo-responding in recently abstinent cocaine dependent inpatients.
Topics: Adult; Arousal; Cocaine; Cocaine-Related Disorders; Comorbidity; Female; Galvanic Skin Response; Humans; Male; Mental Disorders; Substance Withdrawal Syndrome; Treatment Outcome | 2000 |
Cocaine-induced behavioral sensitization in the young rat.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Environment; Motor Activity; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2000 |
Neurocognitive functioning in recently abstinent, cocaine-abusing schizophrenic patients.
Topics: Adult; Attention; Cocaine; Cocaine-Related Disorders; Female; Humans; Male; Mental Recall; Middle Aged; Neuropsychological Tests; Psychometrics; Schizophrenia; Schizophrenic Psychology; Serial Learning; Substance Withdrawal Syndrome; Verbal Learning | 2000 |
Regulation of NMDA receptor subunits and nitric oxide synthase expression during cocaine withdrawal.
Topics: Animals; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Drug Administration Schedule; Hippocampus; Immunohistochemistry; Male; Neostriatum; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2000 |
Cocaine self-administration in rats differentially alters mRNA levels of the monoamine transporters and striatal neuropeptides.
Topics: Animals; Brain Chemistry; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Enkephalins; Gene Expression; Injections, Intravenous; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Rats; Rats, Inbred Strains; RNA, Messenger; Self Administration; Serotonin Plasma Membrane Transport Proteins; Substance P; Substance Withdrawal Syndrome; Symporters | 2000 |
18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of action.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Ibogaine; In Vitro Techniques; Morphine; Psychopharmacology; Self Administration; Substance Withdrawal Syndrome | 2000 |
Reduction of zif268 messenger RNA expression during prolonged withdrawal following "binge" cocaine self-administration in rats.
Topics: Animals; Brain; Cocaine; DNA-Binding Proteins; Early Growth Response Protein 1; Immediate-Early Proteins; Male; Rats; Rats, Long-Evans; Reflex, Startle; RNA, Messenger; Self Administration; Substance Withdrawal Syndrome; Time Factors; Tissue Distribution; Transcription Factors; Vocalization, Animal | 2000 |
Kappa-opioid receptor activation prevents alterations in mesocortical dopamine neurotransmission that occur during abstinence from cocaine.
Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Cocaine-Related Disorders; Dopamine; Drug Interactions; Extracellular Space; Male; Microdialysis; Motor Activity; Neural Pathways; Neurons; Prefrontal Cortex; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Synaptic Transmission; Synaptosomes; Ventral Tegmental Area | 2000 |
Effects of pertussis toxin on behavioral responses during different withdrawal periods from chronic cocaine treatment.
Topics: Adenosine Diphosphate Ribose; Animals; Antipsychotic Agents; Behavior, Animal; Benzazepines; Catalepsy; Cocaine; Dopamine Uptake Inhibitors; Haloperidol; Male; Mice; Pertussis Toxin; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Substance Withdrawal Syndrome; Virulence Factors, Bordetella | 2000 |
Acute abstinence effects following smoked cocaine administration in humans.
Topics: Acute-Phase Reaction; Adult; Affect; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dreams; Female; Humans; Male; Middle Aged; Reaction Time; Sleep; Substance Withdrawal Syndrome; Surveys and Questionnaires | 2000 |
Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: reversal by D(1) antagonists.
Topics: Animals; Behavior, Animal; Benzazepines; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Dopamine D1; Substance Withdrawal Syndrome; Time Factors | 2001 |
Extinction training regulates tyrosine hydroxylase during withdrawal from cocaine self-administration.
Topics: Animals; Cocaine; Extinction, Psychological; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2001 |
Acute withdrawal from repeated cocaine treatment enhances latent inhibition of a conditioned fear response.
Topics: Acoustic Stimulation; Animals; Cocaine; Conditioning, Psychological; Dopamine Uptake Inhibitors; Fear; Male; Motor Activity; Rats; Rats, Wistar; Reflex, Startle; Substance Withdrawal Syndrome | 2001 |
Repeated self-administered cocaine "binges" in rats: effects on cocaine intake and withdrawal.
Topics: Animals; Behavior, Addictive; Cocaine; Dopamine Uptake Inhibitors; Male; Physical Stimulation; Rats; Rats, Long-Evans; Self Administration; Substance Withdrawal Syndrome; Vocalization, Animal | 2001 |
Electroretinogram and cue-elicited craving in withdrawn cocaine-dependent patients: a replication.
Topics: Adolescent; Adult; Cocaine; Cocaine-Related Disorders; Cues; Electroretinography; Female; Humans; Male; Substance Withdrawal Syndrome; Surveys and Questionnaires | 2001 |
Preference for a cocaine-associated environment is attenuated by augmented accumbal serotonin in cocaine withdrawn rats.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Addictive; Cocaine; Conditioning, Psychological; Dopamine Uptake Inhibitors; Environment; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Serotonin; Substance Withdrawal Syndrome | 2001 |
Prepulse inhibition of the acoustic startle response in cocaine-withdrawn rats.
Topics: Acoustic Stimulation; Animals; Cocaine; Dopamine Uptake Inhibitors; Male; Neural Inhibition; Rats; Rats, Sprague-Dawley; Reflex, Startle; Substance Withdrawal Syndrome | 2001 |
Effects of psychostimulant withdrawal on latent inhibition of conditioned active avoidance and prepulse inhibition of the acoustic startle response.
Topics: Acoustic Stimulation; Amphetamine; Animals; Avoidance Learning; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Generalization, Psychological; Male; Motor Activity; Rats; Rats, Wistar; Reflex, Startle; Substance Withdrawal Syndrome | 2001 |
An automated analysis of rat behavior in the forced swim test.
Topics: Amphetamine; Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Software; Substance Withdrawal Syndrome; Swimming; Videotape Recording | 2001 |
Different times of withdrawal from cocaine administration cause changes in muscarinic and dopaminergic receptors in rat premotor cortex.
Topics: Animals; Binding, Competitive; Cocaine; Cocaine-Related Disorders; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Motor Cortex; Neurons; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Muscarinic; Substance Withdrawal Syndrome; Up-Regulation | 2001 |
Impairments of reversal learning and response perseveration after repeated, intermittent cocaine administrations to monkeys.
Topics: Animals; Chlorocebus aethiops; Cocaine; Conditioning, Operant; Discrimination Learning; Dopamine Uptake Inhibitors; Female; Male; Reinforcement Schedule; Reversal Learning; Reward; Substance Withdrawal Syndrome | 2002 |
The dorsomedial shell of the nucleus accumbens facilitates cocaine-induced locomotor activity during the induction of behavioral sensitization.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Immunohistochemistry; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase | 2002 |
Serum prolactin and response to treatment among cocaine-dependent individuals.
Topics: Adult; Ambulatory Care; Black or African American; Cocaine; Cocaine-Related Disorders; Female; Humans; Male; Patient Dropouts; Personality Inventory; Prognosis; Prolactin; Receptors, Dopamine; Reference Values; Substance Withdrawal Syndrome | 2002 |
[Learning in nursing care: snow from yesterday].
Topics: Adult; Cocaine; Drug Overdose; Education, Nursing, Continuing; Humans; Male; Night Care; Patient Care Planning; Substance Withdrawal Syndrome | 2002 |
Repeated cocaine treatment decreases whole-cell calcium current in rat nucleus accumbens neurons.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cocaine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Male; Membrane Potentials; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2002 |
Cocaine and amphetamine attenuate the discriminative stimulus effects of naltrexone in opioid-dependent rhesus monkeys.
Topics: Amphetamine; Animals; Cocaine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2002 |
Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions.
Topics: Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Extracellular Space; Illicit Drugs; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Time Factors | 2002 |
The effects of continuous cocaine duration on the induction of behavioral tolerance and dopamine autoreceptor function.
Topics: Animals; Autoreceptors; Behavior, Animal; Cocaine; Drug Tolerance; Male; Motor Activity; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Substance Withdrawal Syndrome; Time Factors | 2002 |
Management of surgical problems in patients on methadone maintenance.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Cocaine; Female; Heroin Dependence; Humans; Hydromorphone; Liver Diseases; Lung Diseases; Male; Methadone; Middle Aged; Morphine Dependence; Postoperative Complications; Substance Withdrawal Syndrome; Substance-Related Disorders; Surgical Procedures, Operative; Surgical Wound Infection; Thrombophlebitis | 1976 |
Changes in locomotor activity and naloxone-induced jumping in mice produced by WIN 35, 197-2 (ethylketazocine) and morphine.
Topics: Animals; Cocaine; Cyclazocine; Female; Humans; Mice; Morphine; Motor Activity; Naloxone; Narcotics; Substance Withdrawal Syndrome; Time Factors | 1978 |
Consequent events as determinants of drug effects on schedule-controlled behavior: modification of effects of cocaine and d-amphetamine following chronic amphetamine administration.
Topics: Animals; Cocaine; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Tolerance; Haplorhini; Humans; Male; Reinforcement Schedule; Saimiri; Substance Withdrawal Syndrome; Time Factors | 1979 |
Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users.
Topics: Amphetamine; Cocaine; Diazepam; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Morphine Dependence; Phenobarbital; Platelet Aggregation; Substance Withdrawal Syndrome; Substance-Related Disorders; Thrombocytosis | 1979 |
Perinatal drug abuse.
Topics: Amphetamines; Barbiturates; Cannabis; Cocaine; Female; Fetal Alcohol Spectrum Disorders; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lysergic Acid Diethylamide; Methadone; Narcotics; Pregnancy; Substance Withdrawal Syndrome; Substance-Related Disorders; Tranquilizing Agents | 1979 |
[Pharmacopsychoses during drug addiction].
Topics: Amphetamine; Atropine Derivatives; Cannabis; Cocaine; Delusions; Ether; Humans; Hypnotics and Sedatives; Lysergic Acid Diethylamide; Opium; Paranoid Disorders; Personality Disorders; Psychoses, Substance-Induced; Substance Withdrawal Syndrome; Substance-Related Disorders | 1975 |
Effects of street drugs on anesthesia.
Topics: Amphetamines; Analgesia; Anesthesia; Cocaine; Drug Interactions; Drug Tolerance; Ethanol; Hallucinogens; Humans; Hypnotics and Sedatives; Injections, Intravenous; Narcotics; Postoperative Complications; Solvents; Substance Withdrawal Syndrome; Substance-Related Disorders | 1975 |
[Dependence on and preference for morphine. (III) Improvement of spontaneous drug intake after combined treatment with morphine and cocaine].
Topics: Animals; Cocaine; Codeine; Humans; Male; Morphine; Morphine Dependence; Quinine; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1975 |
Zolpidem behavioral pharmacology in baboons: self-injection, discrimination, tolerance and withdrawal.
Topics: Animals; Barbiturates; Cocaine; Discrimination Learning; Drug Tolerance; Hypnotics and Sedatives; Male; Papio; Pyridines; Receptors, GABA-A; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders; Triazolam; Zolpidem | 1992 |
Cue-evoked arousal in cocaine users: a study of variance and predictive value.
Topics: Adult; Arousal; Cocaine; Conditioning, Classical; Cues; Female; Galvanic Skin Response; Humans; Male; Neurologic Examination; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Mr R: a case study of withdrawal.
Topics: Alcoholism; Clonidine; Cocaine; Humans; Male; Methadone; Middle Aged; Neurologic Examination; Opioid-Related Disorders; Placebo Effect; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Effects of withdrawal from chronic cocaine administration on behavior and beta-adrenergic and serotonergic brain receptors in rat.
Topics: Adrenergic beta-Antagonists; Animals; Brain; Cerebral Cortex; Cocaine; Exploratory Behavior; Hippocampus; Motor Activity; Propanolamines; Rats; Receptors, Adrenergic, beta; Receptors, Serotonin; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Systemic administration of dynorphin A(1-13) markedly inhibits different behavioural responses induced by cocaine in the mouse.
Topics: Analgesics; Animals; Behavior, Animal; Benzomorphans; Cocaine; Dynorphins; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Motor Activity; Narcotic Antagonists; Peptide Fragments; Substance Withdrawal Syndrome | 1992 |
Dopaminergic responsivity during cocaine abstinence: a pilot study.
Topics: Adult; Carbidopa; Cocaine; Dopamine Agents; Drug Combinations; Growth Hormone; Homovanillic Acid; Humans; Levodopa; Male; Methoxyhydroxyphenylglycol; Middle Aged; Prolactin; Receptors, Dopamine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Desmethylimipramine attenuates cocaine withdrawal in rats.
Topics: Analysis of Variance; Animals; Cocaine; Desipramine; Kinetics; Male; Predictive Value of Tests; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Self Administration; Self Stimulation; Substance Withdrawal Syndrome | 1992 |
Bromocriptine reverses the elevation in intracranial self-stimulation thresholds observed in a rat model of cocaine withdrawal.
Topics: Analysis of Variance; Animals; Bromocriptine; Cocaine; Disease Models, Animal; Male; Rats; Rats, Wistar; Regression Analysis; Self Stimulation; Substance Withdrawal Syndrome | 1992 |
Increased CSF HVA with craving in long-term abstinent cocaine abusers.
Topics: Adult; Arousal; Cocaine; Follow-Up Studies; Homovanillic Acid; Humans; Male; Motivation; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Decreased activity of rat A10 dopamine neurons following withdrawal from repeated cocaine.
Topics: Animals; Brain; Cocaine; Dopamine; Male; Neurons; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1992 |
Intermittent and continuous cocaine administration: residual behavioral states during withdrawal.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Drug Implants; Injections, Subcutaneous; Male; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1992 |
Use of cocaine to prevent opiate withdrawal.
Topics: Adult; Clinical Protocols; Cocaine; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Methadone; Self Medication; Substance Withdrawal Syndrome | 1992 |
Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats.
Topics: Amphetamine; Animals; Cocaine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Ethanol; Male; Morphine; Naloxone; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 1992 |
[The concealed pill with far-reaching consequences].
Topics: Adult; Cocaine; Diagnosis, Differential; Dystonia; Humans; Male; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Cocaine abstinence: "withdrawal" or residua of chronic intoxication?
Topics: Cocaine; Humans; Poisoning; Substance Withdrawal Syndrome; Substance-Related Disorders; Terminology as Topic | 1992 |
Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration.
Topics: Animals; Cocaine; Dopamine; Injections, Intravenous; Male; Nucleus Accumbens; Rats; Rats, Wistar; Reference Values; Self Administration; Stereotaxic Techniques; Substance Withdrawal Syndrome; Time Factors | 1992 |
The progressive changes of neuronal activities of the nigral dopaminergic neurons upon withdrawal from continuous infusion of cocaine.
Topics: Animals; Apomorphine; Cocaine; Dopamine; Male; Neurons; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substantia Nigra | 1992 |
The stability of neuropsychological test performance in a group of parenteral drug users.
Topics: Adult; Cocaine; Crack Cocaine; Female; Heroin Dependence; Humans; Male; Middle Aged; Neuropsychological Tests; Reproducibility of Results; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Electroencephalographic sleep and mood during cocaine withdrawal.
Topics: Adult; Affect; Cocaine; Electroencephalography; Electrooculography; Female; Humans; Infant, Newborn; Male; Mental Disorders; Psychiatric Status Rating Scales; Serotonin; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Quantitation of rat dopamine transporter mRNA: effects of cocaine treatment and withdrawal.
Topics: Animals; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Rats; Rats, Inbred Strains; RNA, Messenger; Substance Withdrawal Syndrome; Substantia Nigra | 1992 |
Behavioral neurobiological effects of chronic cocaine administration: contrasts between administration paradigms as well as times after withdrawal.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cocaine; Dopamine; Electrophysiology; Rats; Substance Withdrawal Syndrome | 1992 |
Effects of ritanserin and chlordiazepoxide on sleep-wakefulness alterations in rats following chronic cocaine treatment.
Topics: Animals; Chlordiazepoxide; Cocaine; Male; Rats; Rats, Inbred Strains; Ritanserin; Sleep; Sleep, REM; Substance Withdrawal Syndrome; Wakefulness | 1992 |
A learning model of addiction.
Topics: Affect; Arousal; Cocaine; Combined Modality Therapy; Conditioning, Classical; Humans; Motivation; Recurrence; Reinforcement, Psychology; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Cocaine use and withdrawal: the effect on sleep and mood.
Topics: Adult; Affect; Cocaine; Humans; Reaction Time; Sleep Stages; Sleep, REM; Social Behavior; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Protracted withdrawal: sensitization of the anxiogenic response to cocaine in rats concurrently treated with ethanol.
Topics: Alcoholism; Animals; Anxiety; Cocaine; Discrimination Learning; Discrimination, Psychological; Drug Interactions; Ethanol; Male; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Sensitization of locus ceruleus neurons during withdrawal from chronic stimulants and antidepressants.
Topics: Amphetamine; Animals; Cocaine; Desipramine; Electrophysiology; Injections, Intraperitoneal; Locus Coeruleus; Male; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substance Withdrawal Syndrome; Synapses; Time Factors | 1992 |
Dramatic depletion of mesolimbic extracellular dopamine after withdrawal from morphine, alcohol or cocaine: a common neurochemical substrate for drug dependence.
Topics: Alcoholism; Animals; Cocaine; Dopamine; Limbic System; Morphine; Morphine Dependence; Neurons; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1992 |
From the Alcohol, Drug Abuse, and Mental Health Administration.
Topics: Brain; Caffeine; Cocaine; Diazepam; Drug Synergism; Ethanol; Fetus; Humans; Memory; Memory Disorders; Substance Withdrawal Syndrome; United States; United States Substance Abuse and Mental Health Services Administration | 1991 |
Chronic cocaine administration and withdrawal from cocaine modify central neurotensin receptors in rats.
Topics: Animals; Autoradiography; Brain; Cocaine; Rats; Receptors, Neurotensin; Receptors, Neurotransmitter; Substance Withdrawal Syndrome | 1990 |
Effects of acute and chronic administration of delta 9-tetrahy-drocannabinol or cocaine on ethanol intake in a rat model.
Topics: Alcohol Drinking; Animals; Appetitive Behavior; Circadian Rhythm; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Drinking; Dronabinol; Eating; Rats; Substance Withdrawal Syndrome | 1991 |
Current status of tricyclic antidepressants in psychiatry: their pharmacology and clinical applications.
Topics: Aged; Antidepressive Agents, Tricyclic; Anxiety Disorders; Cocaine; Depressive Disorder; Feeding and Eating Disorders; Fluoxetine; Humans; Panic; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
[The current concepts of drugs, drug dependencies and the drug-dependent].
Topics: Cocaine; Heroin Dependence; Humans; Illicit Drugs; Marijuana Abuse; Psychotropic Drugs; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine.
Topics: Analysis of Variance; Animals; Cocaine; Dopamine; Kinetics; Male; Nucleus Accumbens; Perfusion; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Withdrawal of repeated cocaine decreases autoradiographic [3H]mazindol-labelling of dopamine transporter in rat nucleus accumbens.
Topics: Animals; Autoradiography; Carrier Proteins; Cocaine; Corpus Striatum; Densitometry; Desipramine; Dopamine Plasma Membrane Transport Proteins; Down-Regulation; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nucleus Accumbens; Rats; Substance Withdrawal Syndrome | 1991 |
Estradiol enhances behavioral sensitization to cocaine and amphetamine-stimulated striatal [3H]dopamine release.
Topics: Amphetamine; Animals; Body Weight; Cocaine; Corpus Striatum; Dopamine; Drug Synergism; Estradiol; Female; Male; Motor Activity; Organ Size; Pituitary Gland; Progesterone; Rats; Rats, Inbred Strains; Reference Values; Stereotyped Behavior; Substance Withdrawal Syndrome; Uterus | 1991 |
Chronic cocaine administration and withdrawal of cocaine modify neurotensin binding in rat brain.
Topics: Animals; Binding Sites; Brain; Cocaine; Male; Neurotensin; Rats; Rats, Inbred Lew; Substance Withdrawal Syndrome; Time Factors; Tissue Distribution | 1991 |
Changes in mood, craving and sleep during acute abstinence reported by male cocaine addicts.
Topics: Affect; Cocaine; Humans; Male; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Cocaine-related vascular headaches.
Topics: Adult; Cocaine; Crack Cocaine; Dose-Response Relationship, Drug; Female; Humans; Male; Migraine Disorders; Neurologic Examination; Retrospective Studies; Substance Withdrawal Syndrome; Substance-Related Disorders; Vascular Headaches | 1991 |
Clinical phenomenology and neurobiology of cocaine abstinence: a prospective inpatient study.
Topics: Adult; Cocaine; Dopamine; Female; Growth Hormone; Homovanillic Acid; Hospitalization; Humans; Male; Prolactin; Prospective Studies; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Issues regarding short-term abstinence in outpatient cocaine addicts.
Topics: Ambulatory Care; Brain; Cocaine; Humans; Research Design; Substance Withdrawal Syndrome; Substance-Related Disorders; Terminology as Topic; Tomography, Emission-Computed | 1991 |
Prescribing smokable drugs.
Topics: Administration, Inhalation; Amphetamine; Cocaine; Heroin; Humans; Methadone; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Time Factors | 1990 |
Postcocaine anhedonia. An animal model of cocaine withdrawal.
Topics: Analysis of Variance; Animals; Brain; Cocaine; Disease Models, Animal; Male; Rats; Rats, Inbred Strains; Regression Analysis; Self Stimulation; Substance Withdrawal Syndrome | 1991 |
Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery.
Topics: Analysis of Variance; Animals; Autoradiography; Brain; Bromocriptine; Carbon Radioisotopes; Cocaine; Deoxyglucose; Dopamine; Glucose; Male; Organ Specificity; Rats; Rats, Inbred Strains; Reference Values; Reward; Substance Withdrawal Syndrome | 1991 |
Apparent synaptic dopamine deficiency induced by withdrawal from chronic cocaine treatment.
Topics: Animals; Brain Chemistry; Cocaine; Dialysis; Dopamine; Homovanillic Acid; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Synapses | 1991 |
Changes in brain glucose metabolism in cocaine dependence and withdrawal.
Topics: Adolescent; Adult; Ambulatory Care; Basal Ganglia; Brain; Cocaine; Deoxyglucose; Dopamine; Fluorodeoxyglucose F18; Frontal Lobe; Glucose; Humans; Male; Occipital Lobe; Regression Analysis; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Tomography, Emission-Computed | 1991 |
Acute myocardial infarction associated with cocaine withdrawal.
Topics: Adult; Cocaine; Humans; Male; Myocardial Infarction; Substance Withdrawal Syndrome | 1991 |
A simple test of cocaine craving and related responses.
Topics: Affect; Cocaine; Health Status; Hospitalization; Humans; Personality Inventory; Psychiatric Status Rating Scales; Psychometrics; Self Concept; Severity of Illness Index; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Cognitive deficits in abstaining cocaine abusers.
Topics: Adult; Cocaine; Cognition Disorders; Humans; Male; Personality; Reaction Time; Substance Withdrawal Syndrome | 1990 |
Ondansetron inhibits a behavioural consequence of withdrawing from drugs of abuse.
Topics: Animals; Cocaine; Ethanol; Exploratory Behavior; Illicit Drugs; Imidazoles; Male; Mice; Nicotine; Ondansetron; Rats; Rats, Inbred Strains; Serotonin Antagonists; Social Behavior; Substance Withdrawal Syndrome | 1990 |
Dopaminergic sensitivity and cocaine abuse: response to apomorphine.
Topics: Adult; Anxiety; Apomorphine; Attention; Brain; Cocaine; Dopamine; Homovanillic Acid; Humans; Male; Prolactin; Receptors, Dopamine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Cocaine attenuates the severity of naloxone-precipitated opioid withdrawal.
Topics: Adult; Animals; Cocaine; Female; Humans; Male; Naloxone; Opioid-Related Disorders; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
The prevalence and self-reported consequences of cocaine use: an exploratory and descriptive analysis.
Topics: Adult; Aged; Cocaine; Cross-Sectional Studies; Employment; Female; Humans; Incidence; Male; Middle Aged; Substance Withdrawal Syndrome; Substance-Related Disorders; United States | 1990 |
A pilot trial of levodopa/carbidopa in early cocaine abstinence.
Topics: Adult; Arousal; Carbidopa; Cocaine; Drug Therapy, Combination; Humans; Levodopa; Pilot Projects; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
A10 somatodendritic dopamine autoreceptor sensitivity following withdrawal from repeated cocaine treatment.
Topics: Animals; Apomorphine; Brain; Cocaine; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Salicylamides; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Cocaine withdrawal dystonia.
Topics: Cocaine; Dystonia; Humans; Substance Withdrawal Syndrome | 1990 |
Myocardial infarction during cocaine withdrawal.
Topics: Adult; Cocaine; Humans; Male; Myocardial Infarction; Substance Withdrawal Syndrome | 1990 |
Urinary excretion of cocaine.
Topics: Cocaine; Coronary Disease; Humans; Substance Withdrawal Syndrome | 1990 |
The effect of ketotifen in rodent models of anxiety and on the behavioural consequences of withdrawing from treatment with drugs of abuse.
Topics: Animals; Anxiety; Behavior, Animal; Cocaine; Conditioning, Operant; Diazepam; Ethanol; Ketotifen; Male; Mice; Nicotine; Rats; Rats, Inbred Strains; Species Specificity; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Changes in mood, craving, and sleep during short-term abstinence reported by male cocaine addicts. A controlled, residential study.
Topics: Adult; Blood Pressure; Cocaine; Heart Rate; Hospitalization; Humans; Male; Mood Disorders; Psychiatric Status Rating Scales; Psychological Tests; Sleep Wake Disorders; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Substance-Related Disorders; Weight Gain | 1990 |
Nondependent monkeys self-administer hydromorphone.
Topics: Animals; Cocaine; Drug Tolerance; Hydromorphone; Macaca; Macaca fascicularis; Macaca mulatta; Naloxone; Opioid-Related Disorders; Species Specificity; Substance Withdrawal Syndrome; Substance-Related Disorders | 1985 |
Withdrawal from benzodiazepine dependence as a discriminative stimulus.
Topics: Animals; Chlordiazepoxide; Cocaine; Discrimination Learning; Flumazenil; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome | 1989 |
Cocaine abuse and opioid withdrawal.
Topics: Adult; Cocaine; Female; Humans; Male; Narcotics; Severity of Illness Index; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Cocaine and morphine withdrawal.
Topics: Cocaine; Drug Interactions; Female; History, 19th Century; History, 20th Century; Humans; Morphine Dependence; Substance Withdrawal Syndrome; United States | 1989 |
Drug abuse: a biopsychiatric model.
Topics: Amphetamines; Cocaine; Hallucinogens; Humans; Hypnotics and Sedatives; Models, Biological; Narcotics; Neurotransmitter Agents; Phencyclidine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Carbamazepine treatment of cocaine dependence in methadone maintenance patients with dual opiate-cocaine addiction.
Topics: Carbamazepine; Cocaine; Combined Modality Therapy; Dose-Response Relationship, Drug; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
The prevalence and self-reported consequences of cocaine use.
Topics: Adult; Cocaine; Cross-Sectional Studies; Female; Humans; Incidence; Male; Substance Withdrawal Syndrome; Substance-Related Disorders; United States | 1989 |
Amplitude modulated frequency response during acute cocaine intoxication in rabbits.
Topics: Acoustic Stimulation; Animals; Arousal; Auditory Pathways; Cocaine; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials, Auditory; Female; Rabbits; Reaction Time; Signal Processing, Computer-Assisted; Substance Withdrawal Syndrome | 1989 |
Evaluation of cognitive skills in ethanol- and cocaine- dependent patients during detoxification using P300 evoked response potentials (ERPs).
Topics: Adult; Alcoholism; Arousal; Attention; Cocaine; Electroencephalography; Ethanol; Evoked Potentials, Auditory; Female; Humans; Male; Memory; Mental Recall; Reaction Time; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Cocaine attenuates opiate withdrawal in human and rat.
Topics: Adult; Animals; Arousal; Behavior, Animal; Cocaine; Female; Humans; Male; Morphine Dependence; Naloxone; Neurologic Examination; Opioid-Related Disorders; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Use predicts treatment outcome, not opiate dependence or withdrawal.
Topics: Adult; Cocaine; Follow-Up Studies; Humans; Male; Methadone; Naloxone; Opioid-Related Disorders; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Assessment of the abuse potential of acetorphan, an enkephalinase inhibitor.
Topics: Animals; Cocaine; Discrimination, Psychological; Female; Macaca mulatta; Male; Morphine Dependence; Neprilysin; Rats; Rats, Inbred Strains; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders; Thiorphan | 1989 |
Inpatient cocaine abusers: an analysis of psychological and demographic variables.
Topics: Adult; Cocaine; Female; Humans; Male; Psychiatric Department, Hospital; Psychological Tests; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Headaches in hospitalized cocaine users.
Topics: Adult; Cocaine; Female; Headache; Hemiplegia; Humans; Male; Retrospective Studies; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Dystonia related to cocaine withdrawal: a case report and pathogenic hypothesis.
Topics: Adolescent; Cocaine; Dystonia; Female; Humans; Substance Withdrawal Syndrome | 1989 |
Perinatal outcome of infants exposed to cocaine and/or heroin in utero.
Topics: Cocaine; Drug Synergism; Female; Fetal Growth Retardation; Heroin; Humans; Infant, Newborn; Microcephaly; Obstetric Labor, Premature; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Substance Withdrawal Syndrome | 1989 |
Clinical ratings and plasma HVA during cocaine abstinence.
Topics: Adult; Cocaine; Homovanillic Acid; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
The actions of nicotine and cocaine in a mouse model of anxiety.
Topics: Animals; Anxiety; Behavior, Animal; Cocaine; Discrimination, Psychological; Disease Models, Animal; Light; Male; Mice; Mice, Inbred Strains; Nicotine; Substance Withdrawal Syndrome | 1989 |
Myocardial ischemia during cocaine withdrawal.
Topics: Adult; Cocaine; Coronary Disease; Coronary Vasospasm; Dopamine; Electrocardiography; Electrocardiography, Ambulatory; Exercise Test; Humans; Male; Prognosis; Statistics as Topic; Substance Withdrawal Syndrome | 1989 |
Central stimulant abuse: neurochemistry and pharmacotherapy.
Topics: Antipsychotic Agents; Brain; Bromocriptine; Cocaine; Desipramine; Dopamine; Euphoria; Humans; Receptors, Dopamine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1986 |
Treatment of cocaine-induced panic disorder.
Topics: Adult; Agoraphobia; Amphetamine; Cocaine; Fear; Female; Humans; Male; Panic; Risk Factors; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
A comparison of male and female cocaine abusers.
Topics: Adolescent; Adult; Age Factors; Antisocial Personality Disorder; Cocaine; Depressive Disorder; Female; Hospitalization; Humans; Job Satisfaction; Male; Mental Disorders; Motivation; Psychiatric Status Rating Scales; Sex Factors; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Cocaine withdrawal. An effective three-drug regimen.
Topics: Amantadine; Cocaine; Humans; Lorazepam; Substance Withdrawal Syndrome; Substance-Related Disorders; Tryptophan | 1989 |
The airline passenger undergoing withdrawal or overdose from narcotics or other drugs.
Topics: Adult; Aircraft; Amphetamines; Central Nervous System Depressants; Cocaine; Dronabinol; Emergencies; First Aid; Humans; Lysergic Acid Diethylamide; Male; Narcotics; Phencyclidine; Substance Withdrawal Syndrome | 1985 |
Diagnosing depression with the DST and TRH in cocaine and opioid abusers.
Topics: Cocaine; Depressive Disorder; Dexamethasone; Humans; Hydrocortisone; Kinetics; Opioid-Related Disorders; Substance Withdrawal Syndrome; Substance-Related Disorders; Thyrotropin; Thyrotropin-Releasing Hormone | 1986 |
Extinction of conditioned responses in abstinent cocaine or opioid users.
Topics: Adult; Cocaine; Conditioning, Psychological; Extinction, Psychological; Humans; Male; Opioid-Related Disorders; Random Allocation; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
Comparison of the effects of cocaine and d-amphetamine on the pharmacological actions of methadone.
Topics: Analgesia; Animals; Body Temperature; Cocaine; Dextroamphetamine; Drug Interactions; Male; Methadone; Mice; Naloxone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1987 |
Hyperprolactinemia during cocaine withdrawal.
Topics: Adult; Cocaine; Female; Humans; Hyperprolactinemia; Male; Prolactin; Substance Withdrawal Syndrome | 1988 |
Social, motor, and autonomic signs of morphine withdrawal: differential sensitivities to catecholaminergic drugs in mice.
Topics: Animals; Apomorphine; Autonomic Nervous System; Catecholamines; Clonidine; Cocaine; Dextroamphetamine; Levodopa; Mice; Mice, Inbred Strains; Morphine Dependence; Psychomotor Performance; Reaction Time; Social Behavior; Substance Withdrawal Syndrome | 1988 |
A comparison of self-reported symptoms and DSM-III-R criteria for cocaine withdrawal.
Topics: Cocaine; Depression; Dreams; Fatigue; Humans; Sleep Wake Disorders; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
Cocaine abuse treated with phenelzine.
Topics: Blood Pressure; Cocaine; Follow-Up Studies; Humans; Phenelzine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
Cocaine--a particularly addictive drug.
Topics: Cocaine; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders; United States | 1988 |
Stepwise detoxification from cocaine. A promising regimen.
Topics: Adolescent; Adult; Amantadine; Bromocriptine; Cocaine; Desipramine; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Substance Withdrawal Syndrome; Substance-Related Disorders; Tryptophan; Tyrosine | 1988 |
Breaking the cycle of addiction.
Topics: Behavior Therapy; Cocaine; Desipramine; Humans; Mental Disorders; Psychotherapy; Recurrence; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
Interactions of bromocriptine with cocaine.
Topics: Adult; Bromocriptine; Cocaine; Drug Interactions; Female; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
Role of the laboratory in the evaluation of suspected drug abuse.
Topics: Alcoholism; Amphetamines; Chromatography; Chromatography, Gas; Chromatography, Thin Layer; Clinical Laboratory Techniques; Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Hypnotics and Sedatives; Immunoassay; Immunoenzyme Techniques; Lysergic Acid Diethylamide; Marijuana Abuse; Mental Disorders; Opioid-Related Disorders; Phencyclidine; Radioimmunoassay; Substance Withdrawal Syndrome; Substance-Related Disorders | 1986 |
[Drug dependence test on a cerebral insufficiency improver, aniracetam].
Topics: Animals; Brain; Cocaine; Drug Evaluation, Preclinical; Macaca fascicularis; Male; Memory; Methamphetamine; Pentobarbital; Pyrrolidinones; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
Cocaine withdrawal produces behavioral disruptions in rats.
Topics: Animals; Behavior, Animal; Cocaine; Energy Intake; Feeding Behavior; Male; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1987 |
Laboratory diagnosis of cocaine: intoxication and withdrawal.
Topics: Arousal; Biotransformation; Cocaine; Hallucinations; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1986 |
Anxiogenic properties of cocaine withdrawal.
Topics: Animals; Anxiety; Cocaine; Male; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome | 1987 |
Neonatal nightmare: devastating effects of cocaine.
Topics: Cocaine; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
Substance-induced organic mental disorders. A clinical and conceptual approach.
Topics: Adult; Alcoholic Intoxication; Cannabis; Cocaine; Drug Interactions; Humans; Lysergic Acid Diethylamide; Male; Methaqualone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1986 |
'Crack'. Early report on a new drug epidemic.
Topics: Adult; Black or African American; Bromocriptine; Cocaine; Humans; Male; Random Allocation; Sampling Studies; Substance Withdrawal Syndrome; Substance-Related Disorders | 1986 |
Teratogenicity of cocaine in humans.
Topics: Abnormalities, Drug-Induced; Adult; Birth Weight; Cephalometry; Cocaine; Embryonic and Fetal Development; Female; Fetal Death; Humans; Infant, Newborn; Pregnancy; Skull; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
Cocaine withdrawal.
Topics: Ambulatory Care; Cocaine; Humans; Research Design; Substance Withdrawal Syndrome; Substance-Related Disorders; Terminology as Topic | 1987 |
The physiology of cocaine craving and 'crashing'.
Topics: Bromocriptine; Cocaine; Dopamine; Humans; Prolactin; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
Alcohol and drug use in pregnancy: a case for management.
Topics: Alcoholism; Cannabis; Cocaine; Female; Fetal Alcohol Spectrum Disorders; Humans; Infant, Newborn; Narcotics; Pregnancy; Pregnancy Complications; Prenatal Care; Substance Withdrawal Syndrome; Substance-Related Disorders | 1985 |
Abstinence symptomatology and psychiatric diagnosis in cocaine abusers. Clinical observations.
Topics: Adult; Cocaine; Conditioning, Psychological; Cues; Cyclothymic Disorder; Depressive Disorder; Female; Humans; Male; Mental Disorders; Psychiatric Status Rating Scales; Research Design; Substance Withdrawal Syndrome; Substance-Related Disorders | 1986 |
Cocaine infants: a new arrival at hospitals' step?
Topics: Cocaine; Hospital Departments; Humans; Infant, Newborn; Obstetrics and Gynecology Department, Hospital; Substance Withdrawal Syndrome; United States | 1986 |
Opiate and cocaine dependencies. Techniques to help counter the rising tide.
Topics: Ambulatory Care; Blood Pressure; Clonidine; Cocaine; Drug Tolerance; Hospitalization; Humans; Opioid-Related Disorders; Recurrence; Substance Withdrawal Syndrome; Substance-Related Disorders | 1985 |
Trazodone and cocaine abuse.
Topics: Adult; Cocaine; Humans; Male; Piperazines; Substance Withdrawal Syndrome; Substance-Related Disorders; Trazodone | 1985 |
[Drug dependence and addiction from biochemical and pharmaceutical viewpoints].
Topics: Alcoholism; Animals; Cannabis; Central Nervous System Stimulants; Cocaine; Dogs; Haplorhini; Humans; Hypnotics and Sedatives; Lysergic Acid Diethylamide; Mescaline; Morphine Dependence; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Tranquilizing Agents | 1974 |
Heroin and cocaine addiction.
Topics: Adolescent; Adult; Amphetamine; Barbiturates; Cannabis; Cocaine; Dextroamphetamine; Ethanol; Female; Follow-Up Studies; Heroin; Hospitalization; Hospitals, Psychiatric; Humans; Injections, Intravenous; Male; Methadone; Morphine; Substance Withdrawal Syndrome; Substance-Related Disorders; United Kingdom; United States | 1965 |
The pharmacological basis of drug dependence.
Topics: Amphetamine; Barbiturates; Cannabis; Central Nervous System; Cocaine; Ethanol; Hallucinogens; Heroin; Humans; Morphine; Nicotine; Pharmacology; Substance Withdrawal Syndrome; Substance-Related Disorders; Synaptic Transmission | 1970 |
Psychoanalytic considerations of the etiology of compulsive drug use.
Topics: Affective Symptoms; Amphetamine; Barbiturates; Cocaine; Compulsive Behavior; Defense Mechanisms; Emotions; Freudian Theory; Humans; Internal-External Control; Life Style; Methadone; Narcissism; Narcotics; Object Attachment; Peer Group; Psychoanalytic Theory; Psychotropic Drugs; Self Concept; Social Values; Substance Withdrawal Syndrome; Substance-Related Disorders | 1974 |
Role of catecholaminergic mechanisms in the expression of the morphine abstinence syndrome in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Benserazide; Brain Chemistry; Catecholamines; Cocaine; Desipramine; Dextroamphetamine; Dihydroxyphenylalanine; Dopamine; Eye Movements; Humans; Levallorphan; Male; Methyltyrosines; Morphine; Morphine Dependence; Motor Activity; Nasal Mucosa; Norepinephrine; Piperazines; Rats; Serotonin; Substance Withdrawal Syndrome | 1974 |
Proceedings: Study of drug dependence. 11. Cross preference formation between morphine and cocaine in rats.
Topics: Animals; Body Weight; Cocaine; Humans; Morphine Dependence; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1974 |
[Objective and subjective attention disorders following polyvalent drug abuse].
Topics: Adolescent; Adult; Amphetamine; Barbiturates; Cannabis; Cocaine; Cognition Disorders; Factor Analysis, Statistical; Hallucinogens; Humans; Male; Morphinans; Perceptual Disorders; Psychological Tests; Socioeconomic Factors; Substance Withdrawal Syndrome; Substance-Related Disorders | 1972 |
[Emergency treatment and technic of detoxification in juvenile drug addicts].
Topics: Amphetamine; Barbiturates; Cannabis; Chlormethiazole; Cocaine; Diazepam; Emergencies; Humans; Lysergic Acid Diethylamide; Substance Withdrawal Syndrome; Substance-Related Disorders | 1972 |
Narcotic withdrawal in the newborn.
Topics: Birth Weight; Chlorpromazine; Cocaine; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Phenobarbital; Pregnancy; Prognosis; Substance Withdrawal Syndrome; Substance-Related Disorders | 1972 |
Chlormethiazole treatment of abstinence symptoms after drug withdrawal. Preliminary reports. II.
Topics: Adult; Cocaine; Female; Heroin; Humans; Hypnotics and Sedatives; Male; Meperidine; Substance Withdrawal Syndrome; Substance-Related Disorders; Thiazoles | 1966 |
An oral method of the withdrawal treatment of heroin dependence: a five years' study of a combination of diphenoxylate (Lomotil) and chlormethiazole (Heminevrin).
Topics: Adolescent; Adult; Chlormethiazole; Cocaine; Female; Heroin; Humans; Isonipecotic Acids; Male; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1970 |
The drug-using adolescent as a pediatric patient.
Topics: Acute Kidney Injury; Administration, Oral; Adolescent; Alkaline Phosphatase; Amenorrhea; Amphetamine; Barbiturates; Cannabis; Child; Cocaine; Eosinophilia; False Positive Reactions; Female; Hepatic Encephalopathy; Hepatitis B; Heroin; Humans; Injections, Intravenous; Injections, Subcutaneous; Juvenile Delinquency; Lysergic Acid Diethylamide; Peptic Ulcer; Pneumonia; Pseudotumor Cerebri; Substance Withdrawal Syndrome; Substance-Related Disorders | 1970 |
Drug dependence: pharmacological and physiological aspects.
Topics: Amphetamine; Animals; Barbiturates; Brain; Cannabis; Central Nervous System; Cocaine; Drug Tolerance; Guinea Pigs; Heroin; Humans; Hypothalamus; Ileum; Lysergic Acid Diethylamide; Morphine; Morphine Dependence; Nerve Endings; Opium; Psychoses, Substance-Induced; Substance Withdrawal Syndrome; Substance-Related Disorders | 1970 |
The New Haven Methadone Maintenance Program.
Topics: Adult; Amphetamine; Barbiturates; Cocaine; Community Health Services; Community Mental Health Services; Connecticut; Day Care, Medical; Female; Hallucinogens; Humans; Male; Methadone; Middle Aged; Morphine Dependence; Narcotics; Outpatient Clinics, Hospital; Psychotherapy, Group; Substance Withdrawal Syndrome; Substance-Related Disorders | 1970 |
Effects of childhood trauma on BDNF and TBARS during crack-cocaine withdrawal.
Topics: Adult; Adult Survivors of Child Adverse Events; Brain-Derived Neurotrophic Factor; Cocaine-Related Disorders; Crack Cocaine; Female; Humans; Male; Substance Withdrawal Syndrome; Thiobarbituric Acid Reactive Substances; Young Adult | 2020 |
Modulation of neuropeptide Y levels is impaired in crack withdrawal patients.
Topics: Adult; Cocaine-Related Disorders; Crack Cocaine; Humans; Hydrocortisone; Inpatients; Male; Middle Aged; Neuropeptide Y; Stress, Psychological; Substance Withdrawal Syndrome | 2020 |
Evaluation of oxidative stress and brain-derived neurotrophic factor levels related to crack-use detoxification.
Topics: Adult; Biomarkers; Brain-Derived Neurotrophic Factor; Cocaine-Related Disorders; Crack Cocaine; Glutathione; Humans; Male; Nitric Oxide; Oxidative Stress; Substance Withdrawal Syndrome; Superoxide Dismutase; Young Adult | 2018 |
Acute dyskinesia in a patient with schizophrenia.
Topics: Adult; Antipsychotic Agents; Clozapine; Cocaine-Related Disorders; Crack Cocaine; Dyskinesia, Drug-Induced; Humans; Magnetic Resonance Imaging; Male; Neuroimaging; Schizophrenia; Substance Withdrawal Syndrome; Treatment Outcome | 2018 |
Childhood neglect and increased withdrawal and depressive severity in crack cocaine users during early abstinence.
Topics: Adult; Adult Survivors of Child Abuse; Brazil; Child; Child Abuse; Crack Cocaine; Depression; Female; Follow-Up Studies; Humans; Stress, Physiological; Substance Withdrawal Syndrome; Substance-Related Disorders; Young Adult | 2013 |
Increase in brain-derived neurotrophic factor expression in early crack cocaine withdrawal.
Topics: Adult; Biomarkers; Brain-Derived Neurotrophic Factor; Case-Control Studies; Cocaine-Related Disorders; Crack Cocaine; Hospitalization; Humans; Male; Substance Withdrawal Syndrome; Young Adult | 2014 |
Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress.
Topics: Adult; Child; Child Abuse, Sexual; Cocaine-Related Disorders; Crack Cocaine; Female; Follow-Up Studies; Glial Cell Line-Derived Neurotrophic Factor; Humans; Linear Models; Nerve Growth Factor; Nerve Growth Factors; Neurotrophin 3; Stress, Psychological; Substance Withdrawal Syndrome; Time Factors | 2014 |
Early life stress and tumor necrosis factor superfamily in crack cocaine withdrawal.
Topics: Adult; Crack Cocaine; Cytokine TWEAK; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Male; Signal Transduction; Statistics as Topic; Statistics, Nonparametric; Stress, Psychological; Substance Withdrawal Syndrome; Surveys and Questionnaires; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Young Adult | 2014 |
Oxidative stress and BDNF as possible markers for the severity of crack cocaine use in early withdrawal.
Topics: Adult; Biomarkers; Brain-Derived Neurotrophic Factor; Cocaine-Related Disorders; Crack Cocaine; Humans; Male; Oxidative Stress; Severity of Illness Index; Substance Withdrawal Syndrome; Thiobarbituric Acid Reactive Substances; Young Adult | 2014 |
Early abstinence of crack-cocaine is effective to attenuate oxidative stress and to improve antioxidant defences.
Topics: Adult; Antioxidants; Cocaine-Related Disorders; Crack Cocaine; Female; Follow-Up Studies; Glutathione Peroxidase; Humans; Oxidative Stress; Substance Withdrawal Syndrome; Superoxide Dismutase; Surveys and Questionnaires; Time Factors; Treatment Outcome; Young Adult | 2015 |
Glucocorticoid receptor gene modulates severity of depression in women with crack cocaine addiction.
Topics: Adult; Cocaine-Related Disorders; Crack Cocaine; Depression; Female; Follow-Up Studies; Genotyping Techniques; Hospitalization; Humans; Longitudinal Studies; Polymorphism, Single Nucleotide; Receptors, Corticotropin-Releasing Hormone; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Regression Analysis; Substance Withdrawal Syndrome; Tacrolimus Binding Proteins; Young Adult | 2016 |
[Abstinence from cocaine after long-term addiction].
Topics: Adaptation, Psychological; Adult; Behavior, Addictive; Cocaine-Related Disorders; Comorbidity; Crack Cocaine; Female; Follow-Up Studies; Humans; Male; Methadone; Middle Aged; Motivation; Narcotics; Opiate Substitution Treatment; Retrospective Studies; Secondary Prevention; Substance Withdrawal Syndrome; Time Factors | 2011 |
[Neuropsychological impairments in crack cocaine-dependent inpatients: preliminary findings].
Topics: Case-Control Studies; Cocaine-Related Disorders; Cognition Disorders; Crack Cocaine; Cross-Sectional Studies; Female; Humans; Male; Neuropsychological Tests; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome | 2004 |
Caring for Diana.
Topics: Breast Neoplasms; Cocaine-Related Disorders; Comorbidity; Crack Cocaine; Female; Humans; Medicine in Literature; Middle Aged; Physician-Patient Relations; Substance Withdrawal Syndrome; Survivors; Writing | 2005 |
Cocaine users differ from normals on cognitive tasks which show poorer performance during drug abstinence.
Topics: Adult; Attention; Clinical Protocols; Cocaine-Related Disorders; Cognition Disorders; Connecticut; Crack Cocaine; Female; Humans; Longitudinal Studies; Male; Neuropsychological Tests; New York; Reference Values; Self Administration; Smoking; Substance Withdrawal Syndrome | 2008 |
Crack cocaine smokers who turn to drug injection: characteristics, factors associated with injection, and implications for HIV transmission. The Multicenter Crack Cocaine and HIV Infection Study Team.
Topics: Adolescent; Adult; Comorbidity; Crack Cocaine; Female; Heroin Dependence; HIV Infections; Humans; Male; Opioid-Related Disorders; Risk Factors; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; United States | 1996 |
Residual effects of repeated cocaine smoking in humans.
Topics: Adult; Affect; Arousal; Crack Cocaine; Dose-Response Relationship, Drug; Humans; Male; Motivation; Neurologic Examination; Pain Measurement; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Gabapentin abuse in a cocaine user: implications for treatment?
Topics: Acetates; Adult; Amines; Anticonvulsants; Crack Cocaine; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Self Medication; Stress Disorders, Post-Traumatic; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Persistent QEEG abnormality in crack cocaine users at 6 months of drug abstinence.
Topics: Adult; Crack Cocaine; Electroencephalography; Female; Humans; Male; Substance Withdrawal Syndrome; Time Factors | 1998 |
Neuroendocrine effects of d-fenfluramine and bromocriptine following repeated smoked cocaine in humans.
Topics: Adult; Analysis of Variance; Bromocriptine; Crack Cocaine; Fenfluramine; Humans; Hydrocortisone; Male; Middle Aged; Motivation; Prolactin; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 2001 |
Treatment of crack cocaine use with carbamazepine.
Topics: Adult; Carbamazepine; Crack Cocaine; Day Care, Medical; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Substance Abuse Treatment Centers; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |