cobamamide and Hyperplasia

cobamamide has been researched along with Hyperplasia* in 2 studies

Other Studies

2 other study(ies) available for cobamamide and Hyperplasia

Article	Year
[The carcinogenic activity of N-nitroso-N-ethylurea in kidney organ cultures of mice exposed transplacentally to cobalamin coenzymes and folinic acid]. Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 111, Issue:3 Preneoplastic changes in organ cultures of mouse embryonic kidney (OCEK) under transplacental N-nitrosoethyl urea (ENU) did not increase under the influence of Ado-Cbl. The frequency of focal proliferation in OCEK under transplacental influence of Ado-C bl and ENU was 2.2 times less than the combination of carcinogen with MeCbl (32.2% and 71.9%, respectively, P less than 0.01). The number of DNA-synthesising epithelial cells in OCEK were less under transplacental influence of Ado-Cbl (8.6 +/- 1.4%) than in MeCbl or FA (19.4 +/- 1.8% and 16.2 +/- 1.3% respectively, P less than 0.01). Topics: Animals; Cobamides; Epithelium; Ethylnitrosourea; Female; Hyperplasia; Kidney; Leucovorin; Mice; Organ Culture Techniques; Placenta; Pregnancy; Time Factors; Vitamin B 12	1991
[The modifying influence of adenosylcobalamin on the transplacental carcinogenic effect of N-nitroso-N-ethylurea in organ cultures of the kidneys of DBA/2 mice]. Eksperimental'naia onkologiia, 1989, Volume: 11, Issue:3 Transplacental effect of cobalamin coenzyme, adenosylcobalamin (Adocbl), on the carcinogenic action of N-nitroso-N-ethylurea (ENU) was studied in culture of the mouse embryonic kidney tissue by histoautoradiography. Coenzyme methylmalonyl-CoA-mutase, Adocbl, injected into DBA/2 mice in the prenatal period did not stimulate the proliferative activity of epithelial cells of the embryonic kidney. The treatment with Adocbl did not intensify hyperplastic changes common for the early stages of carcinogenesis. The frequency of hyperplastic changes mainly of focal proliferation in kidney explants with the combined administration was considerably lower than with the isolated action of the carcinogen and amounted to 8.7% and 21.5%, respectively (P less than 0.001). Topics: Animals; Autoradiography; Cobamides; Drug Interactions; Embryo, Mammalian; Ethylnitrosourea; Female; Hyperplasia; Kidney; Kidney Neoplasms; Mice; Mice, Inbred DBA; Necrosis; Organ Culture Techniques; Placenta; Pregnancy	1989

Article

Year

[The carcinogenic activity of N-nitroso-N-ethylurea in kidney organ cultures of mice exposed transplacentally to cobalamin coenzymes and folinic acid].

Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 111, Issue:3

Preneoplastic changes in organ cultures of mouse embryonic kidney (OCEK) under transplacental N-nitrosoethyl urea (ENU) did not increase under the influence of Ado-Cbl. The frequency of focal proliferation in OCEK under transplacental influence of Ado-C bl and ENU was 2.2 times less than the combination of carcinogen with MeCbl (32.2% and 71.9%, respectively, P less than 0.01). The number of DNA-synthesising epithelial cells in OCEK were less under transplacental influence of Ado-Cbl (8.6 +/- 1.4%) than in MeCbl or FA (19.4 +/- 1.8% and 16.2 +/- 1.3% respectively, P less than 0.01).

Topics: Animals; Cobamides; Epithelium; Ethylnitrosourea; Female; Hyperplasia; Kidney; Leucovorin; Mice; Organ Culture Techniques; Placenta; Pregnancy; Time Factors; Vitamin B 12

1991

[The modifying influence of adenosylcobalamin on the transplacental carcinogenic effect of N-nitroso-N-ethylurea in organ cultures of the kidneys of DBA/2 mice].

Eksperimental'naia onkologiia, 1989, Volume: 11, Issue:3

Transplacental effect of cobalamin coenzyme, adenosylcobalamin (Adocbl), on the carcinogenic action of N-nitroso-N-ethylurea (ENU) was studied in culture of the mouse embryonic kidney tissue by histoautoradiography. Coenzyme methylmalonyl-CoA-mutase, Adocbl, injected into DBA/2 mice in the prenatal period did not stimulate the proliferative activity of epithelial cells of the embryonic kidney. The treatment with Adocbl did not intensify hyperplastic changes common for the early stages of carcinogenesis. The frequency of hyperplastic changes mainly of focal proliferation in kidney explants with the combined administration was considerably lower than with the isolated action of the carcinogen and amounted to 8.7% and 21.5%, respectively (P less than 0.001).

Topics: Animals; Autoradiography; Cobamides; Drug Interactions; Embryo, Mammalian; Ethylnitrosourea; Female; Hyperplasia; Kidney; Kidney Neoplasms; Mice; Mice, Inbred DBA; Necrosis; Organ Culture Techniques; Placenta; Pregnancy

1989