cobaltous chloride has been researched along with Liver Neoplasms in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (35.71) | 18.2507 |
| 2000's | 7 (25.00) | 29.6817 |
| 2010's | 11 (39.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aasbrenn, M; Abd El-Aty, AM; Abdu, A; Abraha, HB; Achour, A; Acquaroni, M; Addeo, P; Agback, P; Agback, T; Al-Alwan, M; Al-Mazrou, A; Al-Mohanna, F; Aliste, M; Almquist, J; Andel, J; Ando, M; Angelov, A; Annuar, MSM; Antwi, K; Arroliga, AC; Arruda, SLM; Asch, SM; Averous, G; Ayaz, S; Ayer, GB; Bachellier, P; Ball, S; Banijamali, AR; Barden, TC; Bartoncini, S; Bedanie, G; Bellò, M; Benić, F; Berhe, GG; Bertiger, G; Beumer, JH; Bhandari, B; Bond, DS; Boules, M; Braüner Christensen, J; Brown-Johnson, C; Burgstaller, S; Cao, L; Capasso, C; Carlevato, R; Carvalho, AE; Ceci, F; Chagas, ATA; Chavan, SG; Chen, AP; Chen, HC; Chen, J; Chen, Q; Chen, Y; Chen, YF; Christ, ER; Chu, CW; Covey, JM; Coyne, GO'; Cristea, MC; Currie, MG; Dahdal, DN; Dai, L; Dang, Z; de Abreu, NL; de Carvalho, KMB; de la Plaza Llamas, R; Deandreis, D; Del Prete, S; Dennis, JA; Deur, J; Díaz Candelas, DA; Divyapriya, G; Djanani, A; Dodig, D; Doki, Y; Doroshow, JH; Dos Santos, RC; Durairaj, N; Dutra, ES; Eguchi, H; Eisterer, W; Ekmann, A; Elakkad, A; Evans, WE; Fan, W; Fang, Z; Faria, HP; Farris, SG; Fenoll, J; Fernandez-Botran, R; Flores, P; Fujita, J; Gan, L; Gandara, DR; Gao, X; Garcia, AA; Garrido, I; Gebru, HA; Gerger, A; Germano, P; Ghamande, S; Ghebeh, H; Giver Jensen, T; Go, A; Goichot, B; Goldwater, M; Gontero, P; Greil, R; Gruenberger, B; Guarneri, A; Guo, Y; Gupta, S; Haxholdt Lunn, T; Hayek, AJ; He, ML; Hellín, P; Hepprich, M; Hernández de Rodas, E; Hill, A; Hndeya, AG; Holdsworth, LM; Hookey, L; Howie, W; Hu, G; Huang, JD; Huang, SY; Hubmann, E; Hwang, SY; Imamura, H; Imperiale, A; Jiang, JQ; Jimenez, JL; Jin, F; Jin, H; Johnson, KL; Joseph, A; Juwara, L; Kalapothakis, E; Karami, H; Karayağiz Muslu, G; Kawabata, R; Kerwin, J; Khan, I; Khin, S; Kidanemariam, HG; Kinders, RJ; Klepov, VV; Koehler, S; Korger, M; Kovačić, S; Koyappayil, A; Kroll, MH; Kuban, J; Kummar, S; Kung, HF; Kurokawa, Y; Laengle, F; Lan, J; Leal, HG; Lee, MH; Lemos, KGE; Li, B; Li, G; Li, H; Li, X; Li, Y; Li, Z; Liebl, W; Lillaz, B; Lin, F; Lin, L; Lin, MCM; Lin, Y; Lin, YP; Lipton, RB; Liu, J; Liu, W; Liu, Z; Lu, J; Lu, LY; Lu, YJ; Ludwig, S; Luo, Y; Ma, L; Ma, W; Machado-Coelho, GLL; Mahmoodi, B; Mahoney, M; Mahvash, A; Mansour, FA; Mao, X; Marinho, CC; Masferrer, JL; Matana Kaštelan, Z; Melendez-Araújo, MS; Méndez-Chacón, E; Miletić, D; Miller, B; Miller, E; Miller, SB; Mo, L; Moazzen, M; Mohammadniaei, M; Montaz-Rosset, MS; Mousavi Khaneghah, A; Mühlethaler, K; Mukhopadhyay, S; Mulugeta, A; Nambi, IM; Navarro, S; Nazmara, S; Neumann, HJ; Newman, EM; Nguyen, HTT; Nicolato, AJPG; Nicolotti, DG; Nieva, JJ; Nilvebrant, J; Nocentini, A; Nugent, K; Nunez-Rodriguez, DL; Nygren, PÅ; Oberli, A; Oderda, M; Odisio, B; Oehler, L; Otludil, B; Overman, M; Özdemir, M; Pace, KA; Palm, H; Parchment, RE; Parise, R; Passera, R; Pavlovic, J; Pecherstorfer, M; Peng, Z; Pérez Coll, C; Petzer, A; Philipp-Abbrederis, K; Pichler, P; Piekarz, RL; Pilati, E; Pimentel, JDSM; Posch, F; Prager, G; Pressel, E; Profy, AT; Qi, P; Qi, Y; Qiu, C; Rajasekhar, B; Ramia, JM; Raynor, HA; Reis, VW; Reubi, JC; Ricardi, U; Riedl, JM; Romano, F; Rong, X; Rubinstein, L; Rumboldt, Z; Sabir, S; Safaeinili, N; Sala, BM; Sandoval Castillo, L; Sau, M; Sbhatu, DB; Schulte, T; Scott, V; Shan, H; Shao, Y; Shariatifar, N; Shaw, JG; She, Y; Shen, B; Shernyukov, A; Sheth, RA; Shi, B; Shi, R; Shum, KT; Silva, JC; Singh, A; Sinha, N; Sirajudeen, AAO; Slaven, J; Sliwa, T; Somme, F; Song, S; Steinberg, SM; Subramaniam, R; Suetta, C; Sui, Y; Sun, B; Sun, C; Sun, H; Sun, Y; Supuran, CT; Surger, M; Svartz, G; Takahashi, T; Takeno, A; Tam, AL; Tang, Z; Tanner, JA; Tannich, E; Taye, MG; Tekle, HT; Thomas, GJ; Tian, Y; Tobin, JV; Todd Milne, G; Tong, X; Une, C; Vela, N; Venkateshwaran, U; Villagrán de Tercero, CI; Wakefield, JD; Wampfler, R; Wan, M; Wang, C; Wang, J; Wang, L; Wang, S; Waser, B; Watt, RM; Wei, B; Wei, L; Weldemichael, MY; Wellmann, IA; Wen, A; Wild, D; Wilthoner, K; Winder, T; Wing, RR; Winget, M; Wöll, E; Wong, KL; Wong, KT; Wu, D; Wu, Q; Wu, Y; Xiang, T; Xiang, Z; Xu, F; Xu, L; Yamasaki, M; Yamashita, K; Yan, H; Yan, Y; Yang, C; Yang, H; Yang, J; Yang, N; Yang, Y; Yau, P; Yu, M; Yuan, Q; Zhan, S; Zhang, B; Zhang, H; Zhang, J; Zhang, N; Zhang, Y; Zhao, X; Zheng, BJ; Zheng, H; Zheng, W; Zhou, H; Zhou, X; Zhu, S; Zimmer, DP; Zionts, D; Zitella, A; Zlott, J; Zolfaghari, K; Zuo, D; Zur Loye, HC; Žuža, I | 1 |
| Endo, H; Ito, K; Nezu, T; Okada, C; Owada, S; Shida, Y; Tatemichi, M | 1 |
| Li, WY; Liu, YQ; Lu, SH; Qian, YY; Shi, YY; Yan, Y; Yang, T; Zhao, XY | 1 |
| Dong, J; Feng, X; Huang, G; Jiang, Y; Li, X; Liu, J; Qian, C; Shen, J; Wang, Q; Zhang, L; Zhang, Y; Zhu, J | 1 |
| Chen, YT; Ni, JY; Sun, HL; Wu, YD; Xu, LF | 1 |
| Benet, M; Carbajo-Pescador, S; García-Palomo, A; González-Gallego, J; Jover, R; Mauriz, JL; Ordoñez, R | 1 |
| Befani, C; Georgoulias, P; Gkotinakou, IM; Hu, CJ; Liakos, P; Mylonis, I; Simos, G | 1 |
| Lu, S; Ma, W; Shi, X; Wang, Y; Wu, L | 1 |
| Liang, JY; Lü, MD; Pan, FS; Xie, XY; Xu, M; Zheng, SG; Zheng, YL | 1 |
| Bai, M; Chen, J; Huang, M; Lin, Q; Liu, S; Wang, L; Zhou, C | 1 |
| Cao, J; Fan, S; Sun, T; Yang, W | 1 |
| Chan, WK; Chang, A; Li, Y; Wang, D; Wang, Y | 1 |
| Michiels, C; Mottet, D; Piret, JP; Raes, M | 1 |
| Lecocq, C; Michiels, C; Ninane, N; Piret, JP; Raes, M; Toffoli, S | 1 |
| Cosse, JP; Michiels, C; Ninane, N; Piret, JP; Raes, M | 1 |
| Fang, D; Ho, YW; Lai, Z; Lei, Y; Li, Z; Ming, QZ; Ya, K | 1 |
| Ebert, BL; Firth, JD; Pugh, CW; Ratcliffe, PJ | 1 |
| Semenza, GL; Wang, GL | 1 |
| Abraham, NG; Griffin, MO; Kappas, A; Levere, RD; Lutton, JD; Nishimura, M; Shibahara, S | 1 |
| Bunn, HF; Ho, VT | 1 |
| Buchwald, M; dos Santos, CC; Joenje, H; Kruyt, FA; Wevrick, R; Youssoufian, H | 1 |
| fhitelaw, ML; Gassmann, M; Gradin, K; Kvietikova, I; McGuire, J; Poellinger, L; Toftgård, R; Tora, L; Wenger, RH | 1 |
| Prchal, JF; Prchal, JT; Stopka, T; Stopkova, P; Zivny, JH | 1 |
| Agani, F; Semenza, GL | 1 |
| Bauer, C; Gassmann, M; Marti, HH; Wenger, RH | 1 |
| Armstead, V; Caro, J; Leshchinsky, I; Minchenko, A; Opentanova, I; Sang, N; Srinivas, V | 1 |
| Finnberg, N; Högberg, J; Silins, I; Ståhl, A; Stenius, U | 1 |
| Fandrey, J; Jelkmann, W; Seydel, FP; Siegers, CP | 1 |
1 trial(s) available for cobaltous chloride and Liver Neoplasms
27 other study(ies) available for cobaltous chloride and Liver Neoplasms
| Article | Year |
|---|---|
Autophagy‑mediated adaptation of hepatocellular carcinoma cells to hypoxia‑mimicking conditions constitutes an attractive therapeutic target.
Topics: AMP-Activated Protein Kinases; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chromones; Cobalt; Gene Knockdown Techniques; Humans; Liver Neoplasms; Macrolides; Morpholines; Oxygen; Signal Transduction | 2018 |
Extracts of Celastrus Orbiculatus Inhibit Cancer Metastasis by Down-regulating Epithelial-Mesenchymal Transition in Hypoxia-Induced Human Hepatocellular Carcinoma Cells.
Topics: Biomarkers, Tumor; Carcinoma, Hepatocellular; Celastrus; Cell Hypoxia; Cell Proliferation; Cell Shape; Cobalt; Down-Regulation; Epithelial-Mesenchymal Transition; Hep G2 Cells; Humans; Liver Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Plant Extracts; Signal Transduction | 2019 |
Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma.
Topics: Cadherins; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Movement; Cobalt; Epithelial-Mesenchymal Transition; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Prognosis; Protein Stability; Snail Family Transcription Factors; Transcription Factors; Transcription, Genetic; Vimentin | 2013 |
Effects of hypoxia-inducible factor-1α silencing on the proliferation of CBRH-7919 hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cobalt; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Regulation, Neoplastic; Gene Silencing; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Time Factors; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2013 |
Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.
Topics: Angiogenesis Inhibitors; Apoptosis; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Cyclic S-Oxides; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Melatonin; Neovascularization, Pathologic; p300-CBP Transcription Factors; Promoter Regions, Genetic; Signal Transduction; STAT3 Transcription Factor; Transcription, Genetic; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2013 |
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells.
Topics: Amino Acids, Dicarboxylic; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cobalt; Deferoxamine; Erythropoietin; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Phosphoglycerate Kinase; Promoter Regions, Genetic; Propanolamines; Protein Binding; Pyrrolidines; RNA, Messenger; Superoxide Dismutase; Transcription, Genetic; Upstream Stimulatory Factors | 2013 |
Hypoxia-induced overexpression of DEC1 is regulated by HIF-1α in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; RNA, Messenger; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A | 2013 |
Sorafenib blocks the HIF-1α/VEGFA pathway, inhibits tumor invasion, and induces apoptosis in hepatoma cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Niacinamide; Phenylurea Compounds; RNA, Messenger; Sorafenib; Vascular Endothelial Growth Factor A | 2014 |
Regulation of COX-2 expression and epithelial-to-mesenchymal transition by hypoxia-inducible factor-1α is associated with poor prognosis in hepatocellular carcinoma patients post TACE surgery.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Movement; Chemoembolization, Therapeutic; Cobalt; Cyclooxygenase 2; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Middle Aged; Prognosis | 2016 |
Hypoxia-inducible factor-1α downregulation by small interfering RNA inhibits proliferation, induces apoptosis, and enhances radiosensitivity in chemical hypoxic human hepatoma SMMC-7721 cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Growth Processes; Cell Hypoxia; Cell Line, Tumor; Cobalt; Down-Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Radiation Tolerance; RNA, Small Interfering; Transfection | 2011 |
Suppression of the hypoxia inducible factor-1 function by redistributing the aryl hydrocarbon receptor nuclear translocator from nucleus to cytoplasm.
Topics: Amino Acid Sequence; Aryl Hydrocarbon Receptor Nuclear Translocator; Base Sequence; Cell Line, Tumor; Cell Nucleus; Cobalt; Cytoplasm; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoprecipitation; Liver Neoplasms; Luciferases; Molecular Sequence Data; Promoter Regions, Genetic; Protein Multimerization; Transfection; Vascular Endothelial Growth Factor A | 2012 |
CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Hypoxia; Cobalt; Culture Media, Serum-Free; DNA-Binding Proteins; Helix-Loop-Helix Motifs; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Transcription Factors; Tumor Cells, Cultured | 2002 |
Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspases; Cell Hypoxia; Cell Line, Tumor; Cobalt; Culture Media, Serum-Free; DNA-Binding Proteins; Enzyme Activation; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Oxidative Stress; Polymerase Chain Reaction; tert-Butylhydroperoxide; Transcription Factors | 2004 |
Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Hypoxia; Cobalt; DNA Fragmentation; Etoposide; Fluorescent Antibody Technique; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; RNA, Small Interfering; Signal Transduction; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured | 2006 |
Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells.
Topics: Carcinoma, Hepatocellular; Cation Transport Proteins; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cobalt; Cytoplasm; Dose-Response Relationship, Drug; Humans; Hypoxia-Inducible Factor 1; Immunohistochemistry; Iron-Regulatory Proteins; Liver Neoplasms; Protein Isoforms; Time Factors | 2008 |
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line; Cloning, Molecular; Cobalt; Cyanides; Cycloheximide; Enhancer Elements, Genetic; Erythropoietin; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Isoenzymes; L Cells; L-Lactate Dehydrogenase; Liver Neoplasms; Mice; Molecular Sequence Data; Oxygen; Phosphoglycerate Kinase; Promoter Regions, Genetic; Sequence Deletion; Sequence Homology, Nucleic Acid; TATA Box; Transfection; Tumor Cells, Cultured | 1994 |
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction.
Topics: Base Sequence; Cell Hypoxia; Cell Line; Cell Nucleus; Cobalt; Deferoxamine; DNA-Binding Proteins; Erythropoietin; Gene Expression; Hepatoblastoma; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Molecular Sequence Data; Nuclear Proteins; Oligonucleotide Probes; RNA, Neoplasm; Signal Transduction; Transcription Factors; Tumor Cells, Cultured | 1993 |
Coexpression of erythropoietin and heme oxygenase genes in Hep3B cells.
Topics: Carcinoma, Hepatocellular; Cobalt; Erythropoietin; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Humans; Liver Neoplasms; Metalloporphyrins; Protoporphyrins; RNA, Messenger; Tumor Cells, Cultured | 1993 |
Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line; Cobalt; Gene Expression Regulation, Neoplastic; Hemeproteins; Humans; Iron; Kinetics; Liver Neoplasms; Nickel; RNA, Messenger; Time Factors; Transcription, Genetic; Transferrin; Tumor Cells, Cultured | 1996 |
Expression of the Fanconi anemia gene FAC in human cell lines: lack of effect of oxygen tension.
Topics: Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Hypoxia; Cell Line, Transformed; Cobalt; DNA-Binding Proteins; Erythropoietin; Fanconi Anemia; Fanconi Anemia Complementation Group C Protein; Fanconi Anemia Complementation Group Proteins; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Liver Neoplasms; Lymphocytes; Nuclear Proteins; Oxygen; Protein Biosynthesis; Proteins; RNA, Messenger; Tumor Cells, Cultured | 1995 |
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Cytochrome P-450 CYP1A1; Dioxins; DNA-Binding Proteins; Female; Genes, Reporter; HeLa Cells; Helix-Loop-Helix Motifs; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Luciferases; Male; Mutagenesis; Nuclear Proteins; Organ Specificity; Receptors, Aryl Hydrocarbon; Recombinant Fusion Proteins; RNA, Messenger; Sequence Deletion; Signal Transduction; Transcription Factors; Transfection; Tumor Cells, Cultured | 1996 |
Human hematopoietic progenitors express erythropoietin.
Topics: Adult; Antigens, CD34; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cells, Cultured; Cobalt; Culture Media, Serum-Free; Enzyme-Linked Immunosorbent Assay; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Molecular Sequence Data; Peptides; Receptors, Erythropoietin; RNA, Messenger; Tumor Cells, Cultured | 1998 |
Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity.
Topics: Animals; Antimutagenic Agents; Base Sequence; Cell Hypoxia; Chelating Agents; Cobalt; Deferoxamine; DNA; DNA-Binding Proteins; Endothelial Growth Factors; Enzyme Inhibitors; Erythropoietin; Fibroblasts; Gene Expression Regulation, Neoplastic; Hepatoblastoma; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Lymphokines; Mersalyl; Nuclear Proteins; Phosphopyruvate Hydratase; Rats; Receptor, IGF Type 1; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Optimal erythropoietin expression in human hepatoma cell lines requires activation of multiple signalling pathways.
Topics: Carcinoma, Hepatocellular; Cell Count; Cell Hypoxia; Cobalt; Dexamethasone; Erythropoietin; Humans; Interleukin-6; Liver Neoplasms; Oxygen; Signal Transduction | 1998 |
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Deferoxamine; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
Topics: Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Carcinogens; Cell Cycle Proteins; Cobalt; Diethylnitrosamine; DNA Damage; DNA-Binding Proteins; Fatty Acids, Unsaturated; Female; Hepatocytes; Liver Neoplasms; Precancerous Conditions; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Wortmannin | 2001 |
Role of cytochrome P450 in the control of the production of erythropoietin.
Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoietin; Humans; Liver Neoplasms; Methylcholanthrene; Metyrapone; Microsomes; Oxygen; Phenobarbital; Thyroxine; Triiodothyronine; Tumor Cells, Cultured | 1990 |