cobaltous chloride has been researched along with Hepatocellular Carcinoma in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (38.46) | 18.2507 |
| 2000's | 7 (26.92) | 29.6817 |
| 2010's | 9 (34.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Endo, H; Ito, K; Nezu, T; Okada, C; Owada, S; Shida, Y; Tatemichi, M | 1 |
| Li, WY; Liu, YQ; Lu, SH; Qian, YY; Shi, YY; Yan, Y; Yang, T; Zhao, XY | 1 |
| Dong, J; Feng, X; Huang, G; Jiang, Y; Li, X; Liu, J; Qian, C; Shen, J; Wang, Q; Zhang, L; Zhang, Y; Zhu, J | 1 |
| Chen, YT; Ni, JY; Sun, HL; Wu, YD; Xu, LF | 1 |
| Benet, M; Carbajo-Pescador, S; García-Palomo, A; González-Gallego, J; Jover, R; Mauriz, JL; Ordoñez, R | 1 |
| Lu, S; Ma, W; Shi, X; Wang, Y; Wu, L | 1 |
| Liang, JY; Lü, MD; Pan, FS; Xie, XY; Xu, M; Zheng, SG; Zheng, YL | 1 |
| Bai, M; Chen, J; Huang, M; Lin, Q; Liu, S; Wang, L; Zhou, C | 1 |
| Cao, J; Fan, S; Sun, T; Yang, W | 1 |
| Michiels, C; Mottet, D; Piret, JP; Raes, M | 1 |
| Buczko, W; Koda, M; Pawlak, D; Pawlak, S; Wolczynski, S | 1 |
| Lecocq, C; Michiels, C; Ninane, N; Piret, JP; Raes, M; Toffoli, S | 1 |
| Cosse, JP; Michiels, C; Ninane, N; Piret, JP; Raes, M | 1 |
| Fang, D; Ho, YW; Lai, Z; Lei, Y; Li, Z; Ming, QZ; Ya, K | 1 |
| Ebert, BL; Firth, JD; Pugh, CW; Ratcliffe, PJ | 1 |
| Abraham, NG; Griffin, MO; Kappas, A; Levere, RD; Lutton, JD; Nishimura, M; Shibahara, S | 1 |
| Bunn, HF; Ho, VT | 1 |
| Buchwald, M; dos Santos, CC; Joenje, H; Kruyt, FA; Wevrick, R; Youssoufian, H | 1 |
| fhitelaw, ML; Gassmann, M; Gradin, K; Kvietikova, I; McGuire, J; Poellinger, L; Toftgård, R; Tora, L; Wenger, RH | 1 |
| Blanchard, KL; Campbell, L; Hu, B; Wright, E | 1 |
| Prchal, JF; Prchal, JT; Stopka, T; Stopkova, P; Zivny, JH | 1 |
| Bauer, C; Gassmann, M; Marti, HH; Wenger, RH | 1 |
| Bianchi, L; Cairo, G; Tacchini, L | 1 |
| Armstead, V; Caro, J; Leshchinsky, I; Minchenko, A; Opentanova, I; Sang, N; Srinivas, V | 1 |
| Bois-Joyeux, B; Chauvet, C; Danan, JL | 1 |
| Fandrey, J; Jelkmann, W; Seydel, FP; Siegers, CP | 1 |
26 other study(ies) available for cobaltous chloride and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Autophagy‑mediated adaptation of hepatocellular carcinoma cells to hypoxia‑mimicking conditions constitutes an attractive therapeutic target.
Topics: AMP-Activated Protein Kinases; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chromones; Cobalt; Gene Knockdown Techniques; Humans; Liver Neoplasms; Macrolides; Morpholines; Oxygen; Signal Transduction | 2018 |
Extracts of Celastrus Orbiculatus Inhibit Cancer Metastasis by Down-regulating Epithelial-Mesenchymal Transition in Hypoxia-Induced Human Hepatocellular Carcinoma Cells.
Topics: Biomarkers, Tumor; Carcinoma, Hepatocellular; Celastrus; Cell Hypoxia; Cell Proliferation; Cell Shape; Cobalt; Down-Regulation; Epithelial-Mesenchymal Transition; Hep G2 Cells; Humans; Liver Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Plant Extracts; Signal Transduction | 2019 |
Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma.
Topics: Cadherins; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Movement; Cobalt; Epithelial-Mesenchymal Transition; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Prognosis; Protein Stability; Snail Family Transcription Factors; Transcription Factors; Transcription, Genetic; Vimentin | 2013 |
Effects of hypoxia-inducible factor-1α silencing on the proliferation of CBRH-7919 hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cobalt; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Regulation, Neoplastic; Gene Silencing; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Time Factors; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2013 |
Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.
Topics: Angiogenesis Inhibitors; Apoptosis; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Cyclic S-Oxides; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Melatonin; Neovascularization, Pathologic; p300-CBP Transcription Factors; Promoter Regions, Genetic; Signal Transduction; STAT3 Transcription Factor; Transcription, Genetic; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2013 |
Hypoxia-induced overexpression of DEC1 is regulated by HIF-1α in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; RNA, Messenger; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A | 2013 |
Sorafenib blocks the HIF-1α/VEGFA pathway, inhibits tumor invasion, and induces apoptosis in hepatoma cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Niacinamide; Phenylurea Compounds; RNA, Messenger; Sorafenib; Vascular Endothelial Growth Factor A | 2014 |
Regulation of COX-2 expression and epithelial-to-mesenchymal transition by hypoxia-inducible factor-1α is associated with poor prognosis in hepatocellular carcinoma patients post TACE surgery.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Movement; Chemoembolization, Therapeutic; Cobalt; Cyclooxygenase 2; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Middle Aged; Prognosis | 2016 |
Hypoxia-inducible factor-1α downregulation by small interfering RNA inhibits proliferation, induces apoptosis, and enhances radiosensitivity in chemical hypoxic human hepatoma SMMC-7721 cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Growth Processes; Cell Hypoxia; Cell Line, Tumor; Cobalt; Down-Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Radiation Tolerance; RNA, Small Interfering; Transfection | 2011 |
CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Hypoxia; Cobalt; Culture Media, Serum-Free; DNA-Binding Proteins; Helix-Loop-Helix Motifs; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Transcription Factors; Tumor Cells, Cultured | 2002 |
Contribution of quinolinic acid in the development of anemia in renal insufficiency.
Topics: Anemia; Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Survival; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Erythropoiesis; Erythropoietin; Humans; Kidney Failure, Chronic; Male; Neurotoxins; Organ Specificity; Quinolinic Acid; Rats; Rats, Wistar; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspases; Cell Hypoxia; Cell Line, Tumor; Cobalt; Culture Media, Serum-Free; DNA-Binding Proteins; Enzyme Activation; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Oxidative Stress; Polymerase Chain Reaction; tert-Butylhydroperoxide; Transcription Factors | 2004 |
Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Hypoxia; Cobalt; DNA Fragmentation; Etoposide; Fluorescent Antibody Technique; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; RNA, Small Interfering; Signal Transduction; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured | 2006 |
Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells.
Topics: Carcinoma, Hepatocellular; Cation Transport Proteins; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cobalt; Cytoplasm; Dose-Response Relationship, Drug; Humans; Hypoxia-Inducible Factor 1; Immunohistochemistry; Iron-Regulatory Proteins; Liver Neoplasms; Protein Isoforms; Time Factors | 2008 |
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line; Cloning, Molecular; Cobalt; Cyanides; Cycloheximide; Enhancer Elements, Genetic; Erythropoietin; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Isoenzymes; L Cells; L-Lactate Dehydrogenase; Liver Neoplasms; Mice; Molecular Sequence Data; Oxygen; Phosphoglycerate Kinase; Promoter Regions, Genetic; Sequence Deletion; Sequence Homology, Nucleic Acid; TATA Box; Transfection; Tumor Cells, Cultured | 1994 |
Coexpression of erythropoietin and heme oxygenase genes in Hep3B cells.
Topics: Carcinoma, Hepatocellular; Cobalt; Erythropoietin; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Humans; Liver Neoplasms; Metalloporphyrins; Protoporphyrins; RNA, Messenger; Tumor Cells, Cultured | 1993 |
Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line; Cobalt; Gene Expression Regulation, Neoplastic; Hemeproteins; Humans; Iron; Kinetics; Liver Neoplasms; Nickel; RNA, Messenger; Time Factors; Transcription, Genetic; Transferrin; Tumor Cells, Cultured | 1996 |
Expression of the Fanconi anemia gene FAC in human cell lines: lack of effect of oxygen tension.
Topics: Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Hypoxia; Cell Line, Transformed; Cobalt; DNA-Binding Proteins; Erythropoietin; Fanconi Anemia; Fanconi Anemia Complementation Group C Protein; Fanconi Anemia Complementation Group Proteins; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Liver Neoplasms; Lymphocytes; Nuclear Proteins; Oxygen; Protein Biosynthesis; Proteins; RNA, Messenger; Tumor Cells, Cultured | 1995 |
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Cytochrome P-450 CYP1A1; Dioxins; DNA-Binding Proteins; Female; Genes, Reporter; HeLa Cells; Helix-Loop-Helix Motifs; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Luciferases; Male; Mutagenesis; Nuclear Proteins; Organ Specificity; Receptors, Aryl Hydrocarbon; Recombinant Fusion Proteins; RNA, Messenger; Sequence Deletion; Signal Transduction; Transcription Factors; Transfection; Tumor Cells, Cultured | 1996 |
In vivo analysis of DNA-protein interactions on the human erythropoietin enhancer.
Topics: Base Sequence; Binding Sites; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; DNA; DNA Footprinting; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Erythropoietin; Genes; Humans; Molecular Sequence Data; Nucleic Acid Conformation; Polymerase Chain Reaction; Trans-Activators; Tumor Cells, Cultured | 1997 |
Human hematopoietic progenitors express erythropoietin.
Topics: Adult; Antigens, CD34; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cells, Cultured; Cobalt; Culture Media, Serum-Free; Enzyme-Linked Immunosorbent Assay; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Molecular Sequence Data; Peptides; Receptors, Erythropoietin; RNA, Messenger; Tumor Cells, Cultured | 1998 |
Optimal erythropoietin expression in human hepatoma cell lines requires activation of multiple signalling pathways.
Topics: Carcinoma, Hepatocellular; Cell Count; Cell Hypoxia; Cobalt; Dexamethasone; Erythropoietin; Humans; Interleukin-6; Liver Neoplasms; Oxygen; Signal Transduction | 1998 |
HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation.
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Deferoxamine; DNA; DNA-Binding Proteins; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Iron Chelating Agents; Iron Deficiencies; Mice; Mutation; Nuclear Proteins; Promoter Regions, Genetic; Receptors, Transferrin; Response Elements; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1999 |
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Deferoxamine; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Retinoic acid receptor-related orphan receptor (ROR) alpha4 is the predominant isoform of the nuclear receptor RORalpha in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cells.
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Deferoxamine; DNA Primers; Gene Expression Regulation; Humans; Liver; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 1; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor Tyrosine Kinase-like Orphan Receptors; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured; Up-Regulation | 2002 |
Role of cytochrome P450 in the control of the production of erythropoietin.
Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoietin; Humans; Liver Neoplasms; Methylcholanthrene; Metyrapone; Microsomes; Oxygen; Phenobarbital; Thyroxine; Triiodothyronine; Tumor Cells, Cultured | 1990 |