cobalt has been researched along with Liver Neoplasms in 61 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 17 (27.87) | 18.7374 |
1990's | 12 (19.67) | 18.2507 |
2000's | 11 (18.03) | 29.6817 |
2010's | 19 (31.15) | 24.3611 |
2020's | 2 (3.28) | 2.80 |
Authors | Studies |
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Ding, X; Hu, YY; Salameen, H; Wang, YB; Wu, FF; Zheng, KW; Zhu, ZY | 1 |
Bai, Z; Chen, Y; He, D; Li, J; Wang, Y; Wang, Z; Zhang, J; Zhang, Q; Zhao, Q | 1 |
Metzler-Nolte, N; Śmiłowicz, D | 1 |
Aasbrenn, M; Abd El-Aty, AM; Abdu, A; Abraha, HB; Achour, A; Acquaroni, M; Addeo, P; Agback, P; Agback, T; Al-Alwan, M; Al-Mazrou, A; Al-Mohanna, F; Aliste, M; Almquist, J; Andel, J; Ando, M; Angelov, A; Annuar, MSM; Antwi, K; Arroliga, AC; Arruda, SLM; Asch, SM; Averous, G; Ayaz, S; Ayer, GB; Bachellier, P; Ball, S; Banijamali, AR; Barden, TC; Bartoncini, S; Bedanie, G; Bellò, M; Benić, F; Berhe, GG; Bertiger, G; Beumer, JH; Bhandari, B; Bond, DS; Boules, M; Braüner Christensen, J; Brown-Johnson, C; Burgstaller, S; Cao, L; Capasso, C; Carlevato, R; Carvalho, AE; Ceci, F; Chagas, ATA; Chavan, SG; Chen, AP; Chen, HC; Chen, J; Chen, Q; Chen, Y; Chen, YF; Christ, ER; Chu, CW; Covey, JM; Coyne, GO'; Cristea, MC; Currie, MG; Dahdal, DN; Dai, L; Dang, Z; de Abreu, NL; de Carvalho, KMB; de la Plaza Llamas, R; Deandreis, D; Del Prete, S; Dennis, JA; Deur, J; Díaz Candelas, DA; Divyapriya, G; Djanani, A; Dodig, D; Doki, Y; Doroshow, JH; Dos Santos, RC; Durairaj, N; Dutra, ES; Eguchi, H; Eisterer, W; Ekmann, A; Elakkad, A; Evans, WE; Fan, W; Fang, Z; Faria, HP; Farris, SG; Fenoll, J; Fernandez-Botran, R; Flores, P; Fujita, J; Gan, L; Gandara, DR; Gao, X; Garcia, AA; Garrido, I; Gebru, HA; Gerger, A; Germano, P; Ghamande, S; Ghebeh, H; Giver Jensen, T; Go, A; Goichot, B; Goldwater, M; Gontero, P; Greil, R; Gruenberger, B; Guarneri, A; Guo, Y; Gupta, S; Haxholdt Lunn, T; Hayek, AJ; He, ML; Hellín, P; Hepprich, M; Hernández de Rodas, E; Hill, A; Hndeya, AG; Holdsworth, LM; Hookey, L; Howie, W; Hu, G; Huang, JD; Huang, SY; Hubmann, E; Hwang, SY; Imamura, H; Imperiale, A; Jiang, JQ; Jimenez, JL; Jin, F; Jin, H; Johnson, KL; Joseph, A; Juwara, L; Kalapothakis, E; Karami, H; Karayağiz Muslu, G; Kawabata, R; Kerwin, J; Khan, I; Khin, S; Kidanemariam, HG; Kinders, RJ; Klepov, VV; Koehler, S; Korger, M; Kovačić, S; Koyappayil, A; Kroll, MH; Kuban, J; Kummar, S; Kung, HF; Kurokawa, Y; Laengle, F; Lan, J; Leal, HG; Lee, MH; Lemos, KGE; Li, B; Li, G; Li, H; Li, X; Li, Y; Li, Z; Liebl, W; Lillaz, B; Lin, F; Lin, L; Lin, MCM; Lin, Y; Lin, YP; Lipton, RB; Liu, J; Liu, W; Liu, Z; Lu, J; Lu, LY; Lu, YJ; Ludwig, S; Luo, Y; Ma, L; Ma, W; Machado-Coelho, GLL; Mahmoodi, B; Mahoney, M; Mahvash, A; Mansour, FA; Mao, X; Marinho, CC; Masferrer, JL; Matana Kaštelan, Z; Melendez-Araújo, MS; Méndez-Chacón, E; Miletić, D; Miller, B; Miller, E; Miller, SB; Mo, L; Moazzen, M; Mohammadniaei, M; Montaz-Rosset, MS; Mousavi Khaneghah, A; Mühlethaler, K; Mukhopadhyay, S; Mulugeta, A; Nambi, IM; Navarro, S; Nazmara, S; Neumann, HJ; Newman, EM; Nguyen, HTT; Nicolato, AJPG; Nicolotti, DG; Nieva, JJ; Nilvebrant, J; Nocentini, A; Nugent, K; Nunez-Rodriguez, DL; Nygren, PÅ; Oberli, A; Oderda, M; Odisio, B; Oehler, L; Otludil, B; Overman, M; Özdemir, M; Pace, KA; Palm, H; Parchment, RE; Parise, R; Passera, R; Pavlovic, J; Pecherstorfer, M; Peng, Z; Pérez Coll, C; Petzer, A; Philipp-Abbrederis, K; Pichler, P; Piekarz, RL; Pilati, E; Pimentel, JDSM; Posch, F; Prager, G; Pressel, E; Profy, AT; Qi, P; Qi, Y; Qiu, C; Rajasekhar, B; Ramia, JM; Raynor, HA; Reis, VW; Reubi, JC; Ricardi, U; Riedl, JM; Romano, F; Rong, X; Rubinstein, L; Rumboldt, Z; Sabir, S; Safaeinili, N; Sala, BM; Sandoval Castillo, L; Sau, M; Sbhatu, DB; Schulte, T; Scott, V; Shan, H; Shao, Y; Shariatifar, N; Shaw, JG; She, Y; Shen, B; Shernyukov, A; Sheth, RA; Shi, B; Shi, R; Shum, KT; Silva, JC; Singh, A; Sinha, N; Sirajudeen, AAO; Slaven, J; Sliwa, T; Somme, F; Song, S; Steinberg, SM; Subramaniam, R; Suetta, C; Sui, Y; Sun, B; Sun, C; Sun, H; Sun, Y; Supuran, CT; Surger, M; Svartz, G; Takahashi, T; Takeno, A; Tam, AL; Tang, Z; Tanner, JA; Tannich, E; Taye, MG; Tekle, HT; Thomas, GJ; Tian, Y; Tobin, JV; Todd Milne, G; Tong, X; Une, C; Vela, N; Venkateshwaran, U; Villagrán de Tercero, CI; Wakefield, JD; Wampfler, R; Wan, M; Wang, C; Wang, J; Wang, L; Wang, S; Waser, B; Watt, RM; Wei, B; Wei, L; Weldemichael, MY; Wellmann, IA; Wen, A; Wild, D; Wilthoner, K; Winder, T; Wing, RR; Winget, M; Wöll, E; Wong, KL; Wong, KT; Wu, D; Wu, Q; Wu, Y; Xiang, T; Xiang, Z; Xu, F; Xu, L; Yamasaki, M; Yamashita, K; Yan, H; Yan, Y; Yang, C; Yang, H; Yang, J; Yang, N; Yang, Y; Yau, P; Yu, M; Yuan, Q; Zhan, S; Zhang, B; Zhang, H; Zhang, J; Zhang, N; Zhang, Y; Zhao, X; Zheng, BJ; Zheng, H; Zheng, W; Zhou, H; Zhou, X; Zhu, S; Zimmer, DP; Zionts, D; Zitella, A; Zlott, J; Zolfaghari, K; Zuo, D; Zur Loye, HC; Žuža, I | 1 |
Endo, H; Ito, K; Nezu, T; Okada, C; Owada, S; Shida, Y; Tatemichi, M | 1 |
Li, WY; Liu, YQ; Lu, SH; Qian, YY; Shi, YY; Yan, Y; Yang, T; Zhao, XY | 1 |
Fan, K; Hao, C; Jiang, B; Shi, G; Tian, X; Yan, L; Yan, X; Zhang, J; Zhou, M | 1 |
Cui, X; Fang, W; Li, Z; Wang, J; Yue, C; Zhao, H; Zhu, R | 1 |
Dong, J; Feng, X; Huang, G; Jiang, Y; Li, X; Liu, J; Qian, C; Shen, J; Wang, Q; Zhang, L; Zhang, Y; Zhu, J | 1 |
Chen, YT; Ni, JY; Sun, HL; Wu, YD; Xu, LF | 1 |
Benet, M; Carbajo-Pescador, S; García-Palomo, A; González-Gallego, J; Jover, R; Mauriz, JL; Ordoñez, R | 1 |
Befani, C; Georgoulias, P; Gkotinakou, IM; Hu, CJ; Liakos, P; Mylonis, I; Simos, G | 1 |
Lu, S; Ma, W; Shi, X; Wang, Y; Wu, L | 1 |
Beaudoin, G; Leroux, JC; Martel, S; Pouponneau, P; Soulez, G | 1 |
Liang, JY; Lü, MD; Pan, FS; Xie, XY; Xu, M; Zheng, SG; Zheng, YL | 1 |
Gao, XY; Guo, M; Wang, CG; Wu, ZL | 1 |
Bai, M; Chen, J; Huang, M; Lin, Q; Liu, S; Wang, L; Zhou, C | 1 |
Ahamed, M; Akhtar, MJ; Alhadlaq, HA; Alshamsan, A; Khan, MAM | 1 |
Chua, AC; Graham, RM; Herbison, CE; Leedman, P; Olynyk, JK; Thorstensen, K; Trinder, D | 1 |
Breece, RM; Chantranupong, L; Cherukuri, P; Curley, SA; Georgiou, G; Glazer, ES; Iverson, BL; Stone, EM; Tierney, DL | 1 |
Cao, J; Fan, S; Sun, T; Yang, W | 1 |
Chan, WK; Chang, A; Li, Y; Wang, D; Wang, Y | 1 |
Ahamed, M; Al-Khedhairy, AA; Alarifi, S; Ali, D; Siddiqui, MA; Y, AO | 1 |
Michiels, C; Mottet, D; Piret, JP; Raes, M | 1 |
Brooks, K; Miller, AC; Page, N; Smith, J | 1 |
Lecocq, C; Michiels, C; Ninane, N; Piret, JP; Raes, M; Toffoli, S | 1 |
Hogenesch, JB; LaPres, JJ; Phillips, JM; Vengellur, A | 1 |
Cosse, JP; Michiels, C; Ninane, N; Piret, JP; Raes, M | 1 |
Kalla, NR; Naura, AS; Sharma, R; Sharma, RP | 1 |
Fang, D; Ho, YW; Lai, Z; Lei, Y; Li, Z; Ming, QZ; Ya, K | 1 |
Pickart, L; Thaler, MM | 1 |
Ebert, BL; Firth, JD; Gleadle, JM; Ratcliffe, PJ | 1 |
Ebert, BL; Firth, JD; Pugh, CW; Ratcliffe, PJ | 1 |
Semenza, GL; Wang, GL | 1 |
Abraham, NG; Griffin, MO; Kappas, A; Levere, RD; Lutton, JD; Nishimura, M; Shibahara, S | 1 |
Bunn, HF; Ho, VT | 1 |
Buchwald, M; dos Santos, CC; Joenje, H; Kruyt, FA; Wevrick, R; Youssoufian, H | 1 |
fhitelaw, ML; Gassmann, M; Gradin, K; Kvietikova, I; McGuire, J; Poellinger, L; Toftgård, R; Tora, L; Wenger, RH | 1 |
Prchal, JF; Prchal, JT; Stopka, T; Stopkova, P; Zivny, JH | 1 |
Agani, F; Semenza, GL | 1 |
Bauer, C; Gassmann, M; Marti, HH; Wenger, RH | 1 |
Armstead, V; Caro, J; Leshchinsky, I; Minchenko, A; Opentanova, I; Sang, N; Srinivas, V | 1 |
Finnberg, N; Högberg, J; Silins, I; Ståhl, A; Stenius, U | 1 |
Turek, M | 1 |
Krantz, S; Lober, M | 1 |
Guetzow, K; Olson, MO | 1 |
Grisvard, J; Guillé, E; Sissoëff, I | 1 |
Inoue, M; Ishii, H; Oda, T; Utsumi, K | 1 |
Hiwada, K; Kokubu, T; Ono, M; Terao, M | 1 |
Kieraga, L; Modrzewska, R; Radomińska, I; Rzeszowska, G | 1 |
Leaming, RH; Stearns, MW | 1 |
Brookins, J; Fisher, JW; Nakashima, J | 1 |
Fandrey, J; Jelkmann, W; Seydel, FP; Siegers, CP | 1 |
Bunn, HF; Dunning, SP; Goldberg, MA | 2 |
Caro, J; Erslev, AJ; Kaufman, R; Nielsen, OJ; Schuster, SJ | 1 |
Bresnick, E; Thompson, UB | 1 |
Shimizu, T | 1 |
Busch, H; Kang, YJ; Olson, MO | 1 |
Gladysz, A; Szczeklik, A; Szewczuk, A | 1 |
Szczeklik, A; Szewczuk, A | 1 |
2 review(s) available for cobalt and Liver Neoplasms
Article | Year |
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[Congenital and acquired variants of plasma fibrinogen].
Topics: Blood Coagulation Disorders; Cobalt; Fetal Blood; Fibrinogen; Genetic Variation; Hepatitis; Liver Neoplasms | 1976 |
Studies on metal ions-DNA interactions: specific behaviour of reiterative DNA sequences.
Topics: Animals; Base Sequence; Binding Sites; Cadmium; Calcium; Carcinogens; Carcinoma, Hepatocellular; Cobalt; Copper; DNA; DNA, Neoplasm; Hot Temperature; Ions; Liver Neoplasms; Magnesium; Mercury; Metals; Mutagens; Neoplasms, Experimental; Nucleic Acid Denaturation; Palladium; Plant Tumors; Plants; Silver; Zinc | 1976 |
1 trial(s) available for cobalt and Liver Neoplasms
58 other study(ies) available for cobalt and Liver Neoplasms
Article | Year |
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VEGF/Nrp1/HIF-1α promotes proliferation of hepatocellular carcinoma through a positive feedback loop.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cobalt; Feedback; Gene Expression Regulation, Neoplastic; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactates; Liver Neoplasms; Neuropilin-1; Vascular Endothelial Growth Factor A | 2023 |
Synthesis, toxicity and antitumor activity of cobalt carbonyl complexes targeting hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Cobalt; Coordination Complexes; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Embryonic Development; Humans; Liver Neoplasms; Molecular Structure; Structure-Activity Relationship; Tumor Cells, Cultured; Zebrafish | 2019 |
Bioconjugates of Co(III) complexes with Schiff base ligands and cell penetrating peptides: Solid phase synthesis, characterization and antiproliferative activity.
Topics: A549 Cells; Antineoplastic Agents; Cell Proliferation; Cell-Penetrating Peptides; Cobalt; Coordination Complexes; Hep G2 Cells; Humans; Ligands; Liver Neoplasms; Lung Neoplasms; Schiff Bases; Solid-Phase Synthesis Techniques | 2020 |
Autophagy‑mediated adaptation of hepatocellular carcinoma cells to hypoxia‑mimicking conditions constitutes an attractive therapeutic target.
Topics: AMP-Activated Protein Kinases; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chromones; Cobalt; Gene Knockdown Techniques; Humans; Liver Neoplasms; Macrolides; Morpholines; Oxygen; Signal Transduction | 2018 |
Extracts of Celastrus Orbiculatus Inhibit Cancer Metastasis by Down-regulating Epithelial-Mesenchymal Transition in Hypoxia-Induced Human Hepatocellular Carcinoma Cells.
Topics: Biomarkers, Tumor; Carcinoma, Hepatocellular; Celastrus; Cell Hypoxia; Cell Proliferation; Cell Shape; Cobalt; Down-Regulation; Epithelial-Mesenchymal Transition; Hep G2 Cells; Humans; Liver Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Plant Extracts; Signal Transduction | 2019 |
Biomineralization Synthesis of the Cobalt Nanozyme in SP94-Ferritin Nanocages for Prognostic Diagnosis of Hepatocellular Carcinoma.
Topics: alpha-Fetoproteins; Biomineralization; Carcinoma, Hepatocellular; Cobalt; Disease-Free Survival; Enzymes; Female; Ferritins; Genetic Engineering; Hep G2 Cells; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Male; Nanostructures; Peptides; Peroxidase; Prognosis | 2019 |
Nitrogen-doped-carbon-coated hexagonal cobalt oxyhydroxide/reduced graphene oxide nanocomposite for sensitive and selective detection of nitrite in human hepatoma cells.
Topics: Carbon; Carcinoma, Hepatocellular; Cell Line; Cobalt; Graphite; Hep G2 Cells; Humans; Imidazoles; Limit of Detection; Liver; Liver Neoplasms; Nanocomposites; Nitrites; Nitrogen; Oxides; Zeolites | 2019 |
Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma.
Topics: Cadherins; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Movement; Cobalt; Epithelial-Mesenchymal Transition; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Prognosis; Protein Stability; Snail Family Transcription Factors; Transcription Factors; Transcription, Genetic; Vimentin | 2013 |
Effects of hypoxia-inducible factor-1α silencing on the proliferation of CBRH-7919 hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cobalt; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Regulation, Neoplastic; Gene Silencing; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Time Factors; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2013 |
Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.
Topics: Angiogenesis Inhibitors; Apoptosis; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Cyclic S-Oxides; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Melatonin; Neovascularization, Pathologic; p300-CBP Transcription Factors; Promoter Regions, Genetic; Signal Transduction; STAT3 Transcription Factor; Transcription, Genetic; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2013 |
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells.
Topics: Amino Acids, Dicarboxylic; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cobalt; Deferoxamine; Erythropoietin; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Phosphoglycerate Kinase; Promoter Regions, Genetic; Propanolamines; Protein Binding; Pyrrolidines; RNA, Messenger; Superoxide Dismutase; Transcription, Genetic; Upstream Stimulatory Factors | 2013 |
Hypoxia-induced overexpression of DEC1 is regulated by HIF-1α in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; RNA, Messenger; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A | 2013 |
MR imaging of therapeutic magnetic microcarriers guided by magnetic resonance navigation for targeted liver chemoembolization.
Topics: Animals; Chemoembolization, Therapeutic; Cobalt; Doxorubicin; Drug Carriers; Drug Delivery Systems; Feasibility Studies; Iron; Liver; Liver Neoplasms; Magnetic Resonance Imaging; Nanoparticles; Phantoms, Imaging; Rabbits | 2014 |
Sorafenib blocks the HIF-1α/VEGFA pathway, inhibits tumor invasion, and induces apoptosis in hepatoma cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Niacinamide; Phenylurea Compounds; RNA, Messenger; Sorafenib; Vascular Endothelial Growth Factor A | 2014 |
[Synthesis and anti-tumor activity of baicalin-metal complex].
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cobalt; Copper; Drug Delivery Systems; Flavonoids; Humans; Liver Neoplasms; Metals; Nickel; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger | 2014 |
Regulation of COX-2 expression and epithelial-to-mesenchymal transition by hypoxia-inducible factor-1α is associated with poor prognosis in hepatocellular carcinoma patients post TACE surgery.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Movement; Chemoembolization, Therapeutic; Cobalt; Cyclooxygenase 2; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Middle Aged; Prognosis | 2016 |
Cobalt iron oxide nanoparticles induce cytotoxicity and regulate the apoptotic genes through ROS in human liver cells (HepG2).
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Survival; Cobalt; Ferric Compounds; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Metal Nanoparticles; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, X-Ray Emission; Tumor Suppressor Protein p53; X-Ray Diffraction | 2016 |
The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells.
Topics: Antigens, CD; Carcinoma, Hepatocellular; Cell Line, Tumor; Cobalt; Humans; Iron; Liver Neoplasms; Metals; Receptors, Transferrin; RNA, Small Interfering; Transfection; Transferrin; Up-Regulation | 2009 |
Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines.
Topics: Antineoplastic Agents; Arginase; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cobalt; Enzyme Stability; Escherichia coli; Gene Expression; Humans; Liver Neoplasms; Manganese; Melanoma; Neoplasms; X-Ray Absorption Spectroscopy | 2010 |
Hypoxia-inducible factor-1α downregulation by small interfering RNA inhibits proliferation, induces apoptosis, and enhances radiosensitivity in chemical hypoxic human hepatoma SMMC-7721 cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Growth Processes; Cell Hypoxia; Cell Line, Tumor; Cobalt; Down-Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Radiation Tolerance; RNA, Small Interfering; Transfection | 2011 |
Suppression of the hypoxia inducible factor-1 function by redistributing the aryl hydrocarbon receptor nuclear translocator from nucleus to cytoplasm.
Topics: Amino Acid Sequence; Aryl Hydrocarbon Receptor Nuclear Translocator; Base Sequence; Cell Line, Tumor; Cell Nucleus; Cobalt; Cytoplasm; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoprecipitation; Liver Neoplasms; Luciferases; Molecular Sequence Data; Promoter Regions, Genetic; Protein Multimerization; Transfection; Vascular Endothelial Growth Factor A | 2012 |
Oxidative stress contributes to cobalt oxide nanoparticles-induced cytotoxicity and DNA damage in human hepatocarcinoma cells.
Topics: Analysis of Variance; Animals; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cattle; Cobalt; DNA Damage; Hep G2 Cells; Humans; Lipid Peroxidation; Liver Neoplasms; Metal Nanoparticles; Oxidative Stress; Oxides; Reactive Oxygen Species | 2013 |
CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Hypoxia; Cobalt; Culture Media, Serum-Free; DNA-Binding Proteins; Helix-Loop-Helix Motifs; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Transcription Factors; Tumor Cells, Cultured | 2002 |
Effect of the militarily-relevant heavy metals, depleted uranium and heavy metal tungsten-alloy on gene expression in human liver carcinoma cells (HepG2).
Topics: Carcinoma, Hepatocellular; Cobalt; Endoplasmic Reticulum Chaperone BiP; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Nickel; Oligonucleotide Array Sequence Analysis; Transcriptional Activation; Tumor Cells, Cultured; Tungsten Compounds; Uranium | 2004 |
Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspases; Cell Hypoxia; Cell Line, Tumor; Cobalt; Culture Media, Serum-Free; DNA-Binding Proteins; Enzyme Activation; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Oxidative Stress; Polymerase Chain Reaction; tert-Butylhydroperoxide; Transcription Factors | 2004 |
Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells.
Topics: Algorithms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cobalt; Deferoxamine; DNA Primers; Down-Regulation; Erythrocytes; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Liver Neoplasms; Nickel; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Oligonucleotides; Oxygen; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Transcription, Genetic; Up-Regulation | 2005 |
Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Hypoxia; Cobalt; DNA Fragmentation; Etoposide; Fluorescent Antibody Technique; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; RNA, Small Interfering; Signal Transduction; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured | 2006 |
Anticarcinogenic effects of hexaamminecobalt(III) chloride in mice initiated with diethylnitrosamine.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Catalase; Cobalt; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; L-Lactate Dehydrogenase; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Superoxide Dismutase | 2007 |
Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells.
Topics: Carcinoma, Hepatocellular; Cation Transport Proteins; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cobalt; Cytoplasm; Dose-Response Relationship, Drug; Humans; Hypoxia-Inducible Factor 1; Immunohistochemistry; Iron-Regulatory Proteins; Liver Neoplasms; Protein Isoforms; Time Factors | 2008 |
Growth-modulating tripeptide (glycylhistidyllysine): association with copper and iron in plasma, and stimulation of adhesiveness and growth of hepatoma cells in culture by tripeptide-metal ion complexes.
Topics: Carcinoma, Hepatocellular; Cell Adhesion; Cell Division; Cell Line; Cobalt; Copper; DNA; Humans; Iron; Lactates; Liver Neoplasms; Oligopeptides; Zinc | 1980 |
Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents.
Topics: Angiogenesis Inducing Agents; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line; Chelating Agents; Cobalt; Deferoxamine; Endothelial Growth Factors; Erythropoietin; Gene Expression Regulation, Neoplastic; Growth Substances; Humans; Liver Neoplasms; Lymphokines; Molecular Sequence Data; Neovascularization, Pathologic; Placenta Growth Factor; Platelet-Derived Growth Factor; Pregnancy Proteins; RNA, Messenger; RNA, Small Nuclear; Transforming Growth Factor beta; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1995 |
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line; Cloning, Molecular; Cobalt; Cyanides; Cycloheximide; Enhancer Elements, Genetic; Erythropoietin; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Isoenzymes; L Cells; L-Lactate Dehydrogenase; Liver Neoplasms; Mice; Molecular Sequence Data; Oxygen; Phosphoglycerate Kinase; Promoter Regions, Genetic; Sequence Deletion; Sequence Homology, Nucleic Acid; TATA Box; Transfection; Tumor Cells, Cultured | 1994 |
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction.
Topics: Base Sequence; Cell Hypoxia; Cell Line; Cell Nucleus; Cobalt; Deferoxamine; DNA-Binding Proteins; Erythropoietin; Gene Expression; Hepatoblastoma; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Molecular Sequence Data; Nuclear Proteins; Oligonucleotide Probes; RNA, Neoplasm; Signal Transduction; Transcription Factors; Tumor Cells, Cultured | 1993 |
Coexpression of erythropoietin and heme oxygenase genes in Hep3B cells.
Topics: Carcinoma, Hepatocellular; Cobalt; Erythropoietin; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Humans; Liver Neoplasms; Metalloporphyrins; Protoporphyrins; RNA, Messenger; Tumor Cells, Cultured | 1993 |
Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line; Cobalt; Gene Expression Regulation, Neoplastic; Hemeproteins; Humans; Iron; Kinetics; Liver Neoplasms; Nickel; RNA, Messenger; Time Factors; Transcription, Genetic; Transferrin; Tumor Cells, Cultured | 1996 |
Expression of the Fanconi anemia gene FAC in human cell lines: lack of effect of oxygen tension.
Topics: Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Hypoxia; Cell Line, Transformed; Cobalt; DNA-Binding Proteins; Erythropoietin; Fanconi Anemia; Fanconi Anemia Complementation Group C Protein; Fanconi Anemia Complementation Group Proteins; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Liver Neoplasms; Lymphocytes; Nuclear Proteins; Oxygen; Protein Biosynthesis; Proteins; RNA, Messenger; Tumor Cells, Cultured | 1995 |
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Cytochrome P-450 CYP1A1; Dioxins; DNA-Binding Proteins; Female; Genes, Reporter; HeLa Cells; Helix-Loop-Helix Motifs; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Luciferases; Male; Mutagenesis; Nuclear Proteins; Organ Specificity; Receptors, Aryl Hydrocarbon; Recombinant Fusion Proteins; RNA, Messenger; Sequence Deletion; Signal Transduction; Transcription Factors; Transfection; Tumor Cells, Cultured | 1996 |
Human hematopoietic progenitors express erythropoietin.
Topics: Adult; Antigens, CD34; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cells, Cultured; Cobalt; Culture Media, Serum-Free; Enzyme-Linked Immunosorbent Assay; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Molecular Sequence Data; Peptides; Receptors, Erythropoietin; RNA, Messenger; Tumor Cells, Cultured | 1998 |
Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity.
Topics: Animals; Antimutagenic Agents; Base Sequence; Cell Hypoxia; Chelating Agents; Cobalt; Deferoxamine; DNA; DNA-Binding Proteins; Endothelial Growth Factors; Enzyme Inhibitors; Erythropoietin; Fibroblasts; Gene Expression Regulation, Neoplastic; Hepatoblastoma; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Lymphokines; Mersalyl; Nuclear Proteins; Phosphopyruvate Hydratase; Rats; Receptor, IGF Type 1; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Optimal erythropoietin expression in human hepatoma cell lines requires activation of multiple signalling pathways.
Topics: Carcinoma, Hepatocellular; Cell Count; Cell Hypoxia; Cobalt; Dexamethasone; Erythropoietin; Humans; Interleukin-6; Liver Neoplasms; Oxygen; Signal Transduction | 1998 |
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Deferoxamine; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
Topics: Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Carcinogens; Cell Cycle Proteins; Cobalt; Diethylnitrosamine; DNA Damage; DNA-Binding Proteins; Fatty Acids, Unsaturated; Female; Hepatocytes; Liver Neoplasms; Precancerous Conditions; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Wortmannin | 2001 |
Radiation therapy of the liver metastatic disease.
Topics: Adenocarcinoma; Adult; Alanine Transaminase; Aspartate Aminotransferases; Child; Cobalt; Female; Humans; Liver Function Tests; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Neoplasm Metastasis; Palliative Care; Radiotherapy, High-Energy; Sarcoma, Ewing; Wilms Tumor | 1975 |
Phosphoprotein phosphatase activity of Novikoff hepatoma nucleoli.
Topics: Animals; Calcium; Carcinoma, Hepatocellular; Cell Nucleolus; Cobalt; Dithiothreitol; Edetic Acid; Ethylmaleimide; Kinetics; Liver Neoplasms; Magnesium; Male; Manganese; Neoplasms, Experimental; Phosphoproteins; Phosphoric Monoester Hydrolases; Rats; Zinc | 1976 |
Cellular metabolic control by chemical modification of cell membrane.
Topics: 4-Aminobenzoic Acid; Acrolein; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Membrane; Cells, Cultured; Cobalt; Concanavalin A; Dansyl Compounds; Dicyclohexylcarbodiimide; In Vitro Techniques; Lanthanum; Liver Neoplasms; Mitochondria, Liver; Ouabain; Oxidative Phosphorylation; Oxygen Consumption; Potassium; Rats; Ruthenium Red; Trinitrobenzenesulfonic Acid | 1976 |
Membrane-bound arylamidase from human hepatoma cells having the same electrophoretic mobility as placental membrane-bound arylamidase.
Topics: Aminopeptidases; Carcinoma, Hepatocellular; Cobalt; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; Humans; Liver Neoplasms; Molecular Weight; Neuraminidase; Placenta; Pregnancy; Sialoglycoproteins | 1978 |
[Serum cobalt-activated acylase in patients with viral hepatitis, liver cirrhosis and liver neoplasms].
Topics: Amidohydrolases; Cobalt; Hepatitis, Viral, Human; Humans; Liver Diseases; Liver Neoplasms | 1978 |
Irradiation in inoperable cancer.
Topics: Anus Neoplasms; Bone Neoplasms; Brain Neoplasms; Cobalt; Colonic Neoplasms; Humans; Liver Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Radioisotope Teletherapy; Radiotherapy Dosage; Radiotherapy, High-Energy; Rectal Neoplasms; Recurrence | 1975 |
Characterization of erythropoietin production in a hepatocellular carcinoma cell line.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Carcinoma, Hepatocellular; Cobalt; Colforsin; Cyclic AMP; Erythropoietin; Humans; Hypoxia; Liver Neoplasms; Tumor Cells, Cultured | 1992 |
Role of cytochrome P450 in the control of the production of erythropoietin.
Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoietin; Humans; Liver Neoplasms; Methylcholanthrene; Metyrapone; Microsomes; Oxygen; Phenobarbital; Thyroxine; Triiodothyronine; Tumor Cells, Cultured | 1990 |
Oxygen sensing and erythropoietin gene regulation in a human hepatoma cell line.
Topics: Animals; Biological Assay; Blotting, Northern; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Erythropoietin; Gene Expression Regulation, Neoplastic; Hemeproteins; Humans; Liver Neoplasms; Manganese; Mice; Neoplasm Proteins; Nickel; Oxygen; Radioimmunoassay; RNA, Messenger; Second Messenger Systems; Tumor Cells, Cultured | 1989 |
Regulation of erythropoietin production in a human hepatoblastoma cell line.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cobalt; Cricetinae; Erythropoietin; Glycosylation; Humans; Hypoxia; Liver Neoplasms; Protein Processing, Post-Translational; RNA, Messenger; Transfection; Tumor Cells, Cultured; Tunicamycin | 1987 |
Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein.
Topics: Anaerobiosis; Carbon Monoxide; Carcinoma, Hepatocellular; Cell Line; Cobalt; Cycloheximide; Erythropoietin; Gene Expression Regulation; Genes; Hemeproteins; Humans; Iron; Liver Neoplasms; Manganese; Nickel; Transcription, Genetic | 1988 |
Properties of deoxythymidine kinase partially purified from animal tumors.
Topics: Adenosine Triphosphate; Animals; Barium; Bromodeoxyuridine; Calcium Chloride; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Chromatography, Gel; Cobalt; Enzymes; Floxuridine; In Vitro Techniques; Iron; Kinetics; Liver Neoplasms; Magnesium; Manganese; Nickel; Phosphotransferases; Strontium; Zinc | 1965 |
[Clinical studies on serum leucyl glycyl glycine hydrolyzing enzyme in cancer. I].
Topics: Adult; Aged; Carcinoma, Hepatocellular; Cobalt; Edetic Acid; Electrophoresis; Female; Glycine; Hepatitis; Humans; Leucine; Liver Neoplasms; Male; Manganese; Middle Aged; Neoplasms; Peptide Hydrolases; Pregnancy | 1971 |
Phosphorylation of acid-soluble proteins in isolated nucleoli of Novikoff hepatoma ascites cells. Effects of divalent cations.
Topics: Adenosine Triphosphate; Animals; Calcium; Carcinoma, Hepatocellular; Cell Nucleolus; Cobalt; Cyclic AMP; Electrophoresis, Disc; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Kinetics; Liver Neoplasms; Magnesium; Manganese; Neoplasm Proteins; Neoplasms, Experimental; Phosphoproteins; Phosphorus Radioisotopes; Protein Kinases; Rats; Solubility; Time Factors; Zinc | 1974 |
Serum cobalt-activated acylase activity as a new enzymatic test in viral hepatitis.
Topics: Adolescent; Adult; Aged; Amidohydrolases; Chemical and Drug Induced Liver Injury; Child; Cholecystitis; Cholestasis; Clinical Enzyme Tests; Cobalt; Diagnosis, Differential; Enzyme Activation; Female; Hepatitis; Humans; Jaundice; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged | 1972 |
Cobalt-activated acylase in human serum. Occurrence in hepatobiliary diseases.
Topics: Acetates; Acute Disease; Acyltransferases; Adolescent; Adult; Aged; Amides; Child; Chlorides; Chlorine; Cholangitis; Cholecystitis; Cholestasis; Chronic Disease; Cobalt; Dipeptides; Drug Stability; Enzyme Activation; Glutamates; Hepatitis; Hepatomegaly; Hodgkin Disease; Humans; Hydrogen-Ion Concentration; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Middle Aged; Naphthalenes; Temperature | 1971 |