cobalt and Anoxemia

Topics: Basic Helix-Loop-Helix Transcription Factors; Cobalt; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Endoplasmic Reticulum Stress; Erythropoiesis; Fibrosis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Kidney; Oxidative Stress; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors

Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cobalt; Erythropoietin; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Kidney; Kidney Diseases; Oxygen; Signal Transduction

Topics: Adenine Nucleotides; Adenylyl Cyclases; Animals; Bucladesine; Cobalt; Cyclic AMP; Cyclic GMP; Enzyme Activation; Erythropoietin; Humans; Hypoxia; Kidney; Kidney Cortex; Mice; Phosphoric Diester Hydrolases; Prostaglandins; Protein Kinases; Rats; Stimulation, Chemical; Theophylline

Topics: Anemia; Animals; Blotting, Northern; Cobalt; Erythropoietin; Gene Expression Regulation; Humans; Hypoxia; Mice; Rats; Restriction Mapping; RNA; Transcription, Genetic; Transfection; Tumor Cells, Cultured

Topics: Animals; Cobalt; Erythropoiesis; Erythropoietin; Hormones; Humans; Hypoxia; Kidney; Oxygen

Topics: Animals; Apoptosis; Cells, Cultured; Cobalt; Hypoxia; Intervertebral Disc Degeneration; Nucleus Pulposus; Rats

Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cobalt; Connexin 43; Cytoprotection; Diazoxide; Hypoxia; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac; Potassium Channels; Rats; Reactive Oxygen Species

Topics: Animals; Apoptosis; Cobalt; Complement Activation; Complement Pathway, Alternative; Complement Pathway, Classical; Complement System Proteins; Hydrogen Peroxide; Hypoxia; Lectins; Microglia; Oxidative Stress; Retina; Retinal Ganglion Cells; Retinal Neurons; Stress, Physiological; Swine

Topics: Autophagy; Cell Hypoxia; Cell Survival; Cobalt; Diabetes Mellitus, Type 2; Forkhead Box Protein O1; Humans; Hypoxia; Sequestosome-1 Protein

Topics: Animals; Cobalt; Dose-Response Relationship, Drug; Hypoxia; Inhalation Exposure; Lung Neoplasms; Mice; Oxidative Stress; Pneumonia; Rats; Reactive Oxygen Species; Risk Assessment; Solubility

Topics: Animals; Cobalt; Culture Media, Conditioned; Epithelial Cells; Hypoxia; Oxygen; Sheep; Vascular Endothelial Growth Factor A

Topics: Celastrus; Cell Line, Tumor; Cell Movement; Cobalt; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Matrix Metalloproteinases; Plant Extracts; Stomach Neoplasms; Tumor Microenvironment

Topics: Cobalt; Estrogens; Female; Fetal Growth Retardation; Humans; Hypoxia; Placenta; Pregnancy; RNA, Messenger

Topics: Acetylcysteine; Cobalt; Glucosephosphate Dehydrogenase; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Vascular Diseases

Topics: Bone Morphogenetic Protein 2; Cell Hypoxia; Cells, Cultured; Cobalt; Fibroblasts; Fibrosis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Myringosclerosis; Osteogenesis; Vimentin

Topics: Cadherins; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Hypoxia; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; RNA, Messenger; Vascular Endothelial Growth Factor A; Vimentin

Topics: Adenosine Triphosphate; Antioxidants; Apoptosis; Calcium; Cobalt; Humans; Hypoxia; Mitochondria; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Protons; Reactive Oxygen Species; Signal Transduction

Topics: Cesarean Section; Cobalt; Echinomycin; Female; Glucose; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Methionine; Myometrium; Pregnancy

Topics: Animals; Cobalt; Goats; Humans; Hypoxia; Nuclear Receptor Subfamily 1, Group D, Member 1; Progesterone; RNA, Messenger; Trophoblasts

Topics: Cell Hypoxia; Cell Line; Cobalt; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Oxygen

Topics: Animals; Cell Cycle; Cell Cycle Checkpoints; Cell Hypoxia; Cobalt; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Estradiol; Female; Follicle Stimulating Hormone; Forkhead Box Protein O1; Granulosa Cells; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin-Like Growth Factor I; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Swine

Topics: Animals; Bone Marrow Cells; Cannabinoids; Cell Differentiation; Cells, Cultured; Cobalt; Hypoxia; Mesenchymal Stem Cells; Osteogenesis; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2

Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Antimutagenic Agents; Apoptosis; Arteries; Cobalt; Cochlea; Connexin 43; Gene Expression Regulation; Guinea Pigs; Hypoxia; Muscle, Smooth, Vascular; Reactive Oxygen Species

Topics: Animals; Aorta, Abdominal; Cell Hypoxia; Cell Line; Cell Movement; Cell Proliferation; Circadian Clocks; Cobalt; Disease Models, Animal; Female; Gene Expression Regulation; Gene Silencing; Humans; Hypoxia; Placenta; Pre-Eclampsia; Pregnancy; Rats; RNA, Messenger; Signal Transduction; Transfection; Trophoblasts; Uterine Artery

Topics: Animals; Caspase 1; Choline Deficiency; Cobalt; Disease Models, Animal; Extracellular Vesicles; Fatty Acids, Nonesterified; Gene Expression Regulation; Hepatocytes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammasomes; Inflammation; Interleukin-1beta; Kupffer Cells; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Rats; Sleep Apnea, Obstructive; Triglycerides

Topics: Animals; Cell Communication; Cell Hypoxia; Cobalt; Culture Media; Disease Models, Animal; Disease Progression; Extracellular Vesicles; Fatty Acids, Nonesterified; Hep G2 Cells; Hepatic Stellate Cells; Hepatocytes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Cirrhosis; Male; Mice; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Sleep Apnea, Obstructive

Topics: Ananas; Caco-2 Cells; Cell Hypoxia; Cobalt; Fibroblast Growth Factors; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Vascular Endothelial Growth Factor A

Topics: Alkaline Phosphatase; Apoptosis; Autophagy; Cell Proliferation; Cobalt; Collagen Type I; Collagen Type I, alpha 1 Chain; Core Binding Factor Alpha 1 Subunit; Cyclin-Dependent Kinase 8; Endoplasmic Reticulum Stress; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mesenchymal Stem Cells; Osteocalcin; Osteogenesis; Periodontal Ligament; Periodontitis; RNA, Circular; Signal Transduction

Topics: Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cobalt; Extracellular Matrix; Fibronectins; Humans; Hypoxia; Kidney Neoplasms; Tumor Microenvironment

Topics: Aged; Animals; Cobalt; Disease Models, Animal; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Infant, Newborn; Macular Degeneration; Mice; Neovascularization, Pathologic; Oryza; Retina; Retinal Pigment Epithelium; Rice Bran Oil; Vascular Endothelial Growth Factor A; Vitamin B 6

Topics: Cobalt; Endothelial Cells; Humans; Hypoxia; Nanocomposites; Nanotubes, Carbon; Stem Cells; Vascular Endothelial Growth Factor A

Topics: AMP-Activated Protein Kinases; Animals; Cobalt; Culture Media, Conditioned; Dental Pulp; Humans; Hypoxia; Mice; Myoblasts

Topics: Animals; Apoptosis; Cell Death; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Hypoxia; Interleukin-6; Membrane Potential, Mitochondrial; Neuroprotective Agents; Oxidative Stress; Rats; Retina; Signal Transduction; STAT3 Transcription Factor

Topics: Cell Line, Tumor; Cobalt; Fibroblasts; Gene Expression Regulation; Gene Knockout Techniques; Gene Silencing; Genetic Loci; Humans; Hypoxia; Neoplasms; Promyelocytic Leukemia Protein; Protein Binding; Protein Biosynthesis; Radiation, Ionizing; TOR Serine-Threonine Kinases; Transcription Factors; Transcription, Genetic

Topics: Animals; Animals, Newborn; Butadienes; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Protein-delta; Cobalt; Diabetic Retinopathy; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Signaling System; Neovascularization, Pathologic; Nitriles; Proto-Oncogene Proteins c-fos; Rats; Receptors, G-Protein-Coupled; Retina; Vascular Endothelial Growth Factor A

Topics: Aminolevulinic Acid; Apoptosis; Cell Adhesion Molecules; Cell Count; Cell Line, Tumor; Cell Survival; Cobalt; Colorectal Neoplasms; Disease Progression; Humans; Hypoxia; Intercellular Adhesion Molecule-1; Photochemotherapy; Photosensitizing Agents; Vascular Cell Adhesion Molecule-1

Topics: 5' Untranslated Regions; Animals; Base Sequence; Blotting, Western; Cobalt; Fructosephosphates; Glioma; Hypoxia; Internal Ribosome Entry Sites; Phosphofructokinase-1; Polypyrimidine Tract-Binding Protein; Promoter Regions, Genetic; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation

Topics: Animals; Cell Enlargement; Cell Line; Cell Survival; Cobalt; Edema, Cardiac; Elasticity; Histone Deacetylase 1; Hypoxia; Myocytes, Cardiac; Protective Agents; Rats

Topics: Animals; Blotting, Western; Cell Differentiation; Cell Movement; Cell Proliferation; Cobalt; Core Binding Factor Alpha 1 Subunit; Dental Enamel Proteins; Down-Regulation; Endopeptidases; Humans; Hypoxia; Matrix Metalloproteinase 2; Osteogenesis; Peptide Fragments; Periodontal Ligament; Reference Standards; RNA, Messenger; Swine

Topics: Animals; Cell Movement; Cell Shape; Cobalt; Female; Hypoxia; Insulin-Like Growth Factor I; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neovascularization, Pathologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley

Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell Movement; Cobalt; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Hypoxia; JNK Mitogen-Activated Protein Kinases; Male; Matrix Metalloproteinase 7; Matrix Metalloproteinase 9; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Osteogenesis; Phosphorylation; Receptors, CXCR4; Signal Transduction; STAT3 Transcription Factor

Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Cell Survival; Cobalt; Colonic Neoplasms; Dose-Response Relationship, Drug; Humans; Hypoxia; Interleukin-10; Interleukin-6; Interleukin-8; Interleukins; Photochemotherapy; Photosensitizing Agents

Topics: Animals; Apoptosis Regulatory Proteins; Biomarkers; Cells, Cultured; Chondrocytes; Chondrogenesis; Cobalt; Growth Plate; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Phenotype; Protein Serine-Threonine Kinases; Rats; Signal Transduction; YAP-Signaling Proteins

Topics: Adult; Apoptosis; Apoptosis Regulatory Proteins; Cell Hypoxia; Cell Survival; China; Cobalt; Collagen Type I; Collagen Type I, alpha 1 Chain; Female; Fibroblasts; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ligaments; Membrane Potential, Mitochondrial; Mitochondria; Pelvic Organ Prolapse; Primary Cell Culture; Receptors, Death Domain; Signal Transduction; Uterus

Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antimutagenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Blotting, Western; Cell Line; Cobalt; Cytoprotection; Humans; Hypoxia; Middle Aged; Oxidative Stress; Pentacyclic Triterpenes; Reactive Oxygen Species; Retinal Pigment Epithelium; Triterpenes

Topics: Apoptosis; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Hypoxia; Receptors, G-Protein-Coupled; Retinal Ganglion Cells

Topics: Cell Line; Cobalt; Deoxyribonuclease I; DNA, Viral; Gene Expression; Gene Expression Regulation, Enzymologic; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B virus; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Liver Cirrhosis; Mutation; Virion; Virus Replication

Topics: Apoptosis; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Humans; Hypoxia; JNK Mitogen-Activated Protein Kinases; Propofol; Reactive Oxygen Species

Topics: Actins; Animals; Biomarkers; Calcium-Binding Proteins; Calponins; Cell Hypoxia; Cobalt; Down-Regulation; ets-Domain Protein Elk-1; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male; Microfilament Proteins; Models, Biological; Myocytes, Smooth Muscle; Nuclear Proteins; Osteopontin; Phenotype; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Serine-Threonine Kinases; Pulmonary Artery; Rats, Sprague-Dawley; RNA, Messenger; Serum Response Factor; Trans-Activators; Vascular Remodeling

Topics: Acetylcysteine; Animals; Aquaporin 5; Cell Hypoxia; Cell Line; Cobalt; Epithelial Cells; Gene Expression; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Mice; Oxygen; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Respiratory Mucosa; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Water

Topics: Cadherins; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Movement; Cobalt; Epithelial-Mesenchymal Transition; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Prognosis; Protein Stability; Snail Family Transcription Factors; Transcription Factors; Transcription, Genetic; Vimentin

Topics: Animals; Apoptosis; Cardiotonic Agents; Caryophyllaceae; Cell Line; Cell Survival; Cobalt; Hypoxia; L-Lactate Dehydrogenase; Malondialdehyde; Myocytes, Cardiac; Plant Extracts; Plant Roots; Rats; Reactive Oxygen Species; Superoxide Dismutase

Topics: Animals; Cobalt; Hydrogen Sulfide; Hypoxia; Inflammation; Interleukin-6; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Rats; Reactive Oxygen Species

Topics: Actins; Angiotensin I; Animals; Cell Line; Cobalt; Collagen Type I; Epithelial-Mesenchymal Transition; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Peptide Fragments; Rats

Topics: Animals; Antimutagenic Agents; Apoptosis; Blotting, Western; Cell Proliferation; Cells, Cultured; Cobalt; Ginsenosides; Hydrogen Peroxide; Hypoxia; Neuroprotective Agents; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; RNA, Messenger

Topics: Animals; Brain; Brain Chemistry; Cobalt; Disease Models, Animal; Hypoxia; Male; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Sleep Apnea, Obstructive

Topics: Adenosine Triphosphate; Autophagy; Cell Adhesion; Cell Line; Cell Movement; Cobalt; Decidua; Energy Metabolism; Female; Gene Expression Regulation, Developmental; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Matrix Metalloproteinase 9; Pregnancy; Pregnancy Trimester, First; Receptors, Purinergic P2X7; Signal Transduction; Trophoblasts

Topics: Animals; bcl-2-Associated X Protein; Cell Line; Cobalt; Gene Expression; Gene Expression Regulation; Genes, Reporter; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Nuclear Proteins; Oxidative Stress; Promoter Regions, Genetic; Protein Binding; Rats; Repressor Proteins; RNA Interference; Transcriptional Activation

Topics: Cell Hypoxia; Cell Line, Tumor; Choriocarcinoma; Cobalt; Disulfides; Female; Gene Knockdown Techniques; HSP70 Heat-Shock Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Indole Alkaloids; Placenta; Pre-Eclampsia; Pregnancy; RNA, Small Interfering; Transcription Factors

Topics: Animals; Apoptosis; Cation Transport Proteins; Cell Movement; Cell Proliferation; Chelating Agents; Cobalt; Copper; Down-Regulation; Gene Knockdown Techniques; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Male; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Proliferating Cell Nuclear Antigen; Protein-Lysine 6-Oxidase; Proto-Oncogene Proteins c-bcl-2; Pulmonary Artery; RNA, Messenger; RNA, Small Interfering; Up-Regulation

Topics: Animals; Antimutagenic Agents; Biomarkers; Cobalt; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Hypoxia; Mice; Mice, Inbred C57BL; Retina; Retinal Neurons

Topics: Animals; beta-Transducin Repeat-Containing Proteins; Cobalt; Endothelium, Vascular; Enzyme Stability; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Male; Mice; Mice, Inbred C57BL; N-Acetylglucosaminyltransferases; Proteasome Endopeptidase Complex; Proteolysis; Reactive Nitrogen Species; Reactive Oxygen Species; Ubiquitin-Protein Ligases

Topics: Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Survival; Cobalt; Gene Expression; Humans; Hypoxia; Mesothelioma; Oxidation-Reduction; Proto-Oncogene Proteins c-yes; Signal Transduction; Tocotrienols; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Animals; Cobalt; DNA; Erythropoietin; Hippocampus; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Models, Animal; Protein Binding; RNA, Messenger; Vascular Endothelial Growth Factor A

Topics: Animals; Blotting, Western; Catalase; Cerebral Cortex; Cobalt; Dose-Response Relationship, Drug; Down-Regulation; Hypoxia; Male; Mice; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase

Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cobalt; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Hypoxia; Mice; Mice, SCID; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Organometallic Compounds; Protein Kinase Inhibitors; Signal Transduction; Structure-Activity Relationship; Tumor Cells, Cultured

Topics: Apoferritins; Cell Line, Tumor; Cobalt; Ferritins; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Iron-Regulatory Proteins; Protein Processing, Post-Translational; RNA, Messenger; Transcription, Genetic; Transcriptional Activation

Topics: Animals; Apoptosis; Caspase 12; Cell Survival; Cells, Cultured; Cinnamates; Cobalt; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Gene Knockdown Techniques; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Neurons; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thiourea; Transcription Factor CHOP

Topics: Biocompatible Materials; Bone and Bones; Bone Regeneration; Cells, Cultured; Cobalt; Collagen; Glass; Glycosaminoglycans; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ions; Neovascularization, Physiologic; Osteoblasts; Osteogenesis; Oxygen; Porosity; Regenerative Medicine; Tissue Engineering; Tissue Scaffolds; Vascular Endothelial Growth Factor A

Topics: Blood-Retinal Barrier; Blotting, Western; Cell Membrane Permeability; Cells, Cultured; Cobalt; Decorin; Dextrans; Diabetic Retinopathy; Electric Impedance; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique; Glucose; Humans; Hypoxia; p38 Mitogen-Activated Protein Kinases; Retinal Pigment Epithelium; RNA, Small Interfering; Tight Junction Proteins

Topics: Cobalt; Humans; Hypoxia; Neurons

Topics: Animals; Biomechanical Phenomena; Bone Remodeling; Cobalt; Disease Models, Animal; Fracture Healing; Fractures, Bone; Hypoxia; Hypoxia-Inducible Factor 1; Immunohistochemistry; Osteogenesis; Rats

Topics: Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Adenoid Cystic; Cell Line, Tumor; Cell Movement; Chloroquine; Cobalt; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Proteins; Microtubule-Associated Proteins; Models, Biological; Neoplasm Invasiveness; Protein Isoforms; Proto-Oncogene Proteins; RNA, Messenger; Salivary Gland Neoplasms; Signal Transduction

Topics: Adenosine Triphosphate; Apoptosis; Calcium; Caspase 3; Caspase 9; Cell Line; Chromatography, Liquid; Citric Acid Cycle; Cobalt; Computational Biology; Glucosides; Hypoxia; Membrane Potentials; Myocytes, Cardiac; Oxygen; Phenols; Plant Extracts; Proteome; Proteomics; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Rhodiola; Tandem Mass Spectrometry; Tricarboxylic Acids

Topics: Aminolevulinic Acid; Anaerobiosis; Apoptosis; Cell Line, Tumor; Cell Survival; Cobalt; Colonic Neoplasms; Dose-Response Relationship, Drug; Fibroblast Growth Factors; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hypoxia; Intercellular Signaling Peptides and Proteins; Photochemotherapy; Photosensitizing Agents

Topics: Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Cobalt; Drug Resistance, Neoplasm; Flow Cytometry; Hodgkin Disease; Humans; Hypoxia

Topics: Animals; Cell Cycle; Cobalt; Gene Expression Regulation; Hypoxia; Lipid Metabolism; Proteomics; Rats; Reactive Oxygen Species

Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cobalt; Disease Models, Animal; Female; Fungal Proteins; Gene Expression Regulation, Fungal; Host-Pathogen Interactions; Hypoxia; Immunocompromised Host; Larva; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Moths; Mutation; Neurospora crassa; Peptide Hydrolases; Signal Transduction; Spores, Fungal; Sterol Regulatory Element Binding Proteins; Ubiquitin-Protein Ligases; Virulence

Topics: Bone Morphogenetic Proteins; Bosentan; Cells, Cultured; Cobalt; Down-Regulation; Endothelin Receptor Antagonists; Humans; Hypoxia; Muscle, Smooth, Vascular; Pulmonary Artery; Signal Transduction; Sulfonamides

Topics: Amyloid Precursor Protein Secretases; Animals; beta Catenin; Cell Line; Cell Proliferation; Cobalt; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Osteoblasts; Receptors, Notch; Signal Transduction; Wnt Proteins; Wnt Signaling Pathway

Topics: Animals; Apoptosis; Cells, Cultured; Cobalt; Cyclosporine; Hypoxia; Immunosuppressive Agents; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Oxidative Stress; Rats

Topics: Ascorbic Acid; Cobalt; Coordination Complexes; Drug Delivery Systems; Hypoxia; Ligands; Models, Biological; Molecular Structure; Oxidation-Reduction; Oxygen; Prodrugs; Triazoles

Topics: Breast Neoplasms; Cobalt; Disease Progression; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; MCF-7 Cells; Oxygen

Topics: Acetylation; Animals; Chlorocebus aethiops; Cobalt; COS Cells; Epigenesis, Genetic; Flavonoids; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hypoxia; p38 Mitogen-Activated Protein Kinases; Phenylbutyrates; Superoxide Dismutase

Topics: Angiogenesis Inhibitors; Animals; Cell Hypoxia; Cell Line; Cobalt; Diabetic Retinopathy; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation; Glucosides; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Indazoles; Ligustrum; Plant Extracts; Pyrans; Rats; Rats, Sprague-Dawley; Retinal Neovascularization; Retinal Pigment Epithelium; Signal Transduction; Vascular Endothelial Growth Factor A

Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Cobalt; Down-Regulation; Female; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasm Proteins; Placenta; Pregnancy; Signal Transduction; Vascular Endothelial Growth Factor A

Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cobalt; Endodeoxyribonucleases; Female; Genetic Therapy; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, SCID; Microscopy, Fluorescence; Neoplasms; Promoter Regions, Genetic; Prostatic Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays

Topics: Activating Transcription Factor 1; Animals; Antioxidants; Cell Line; Cobalt; Hypoxia; Ion Channels; Mice; Mitochondria; Mitochondrial Proteins; Models, Biological; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; RNA, Small Interfering; Transcriptional Activation; Transfection; Uncoupling Protein 3

Topics: Cell Line, Tumor; Cobalt; HSP70 Heat-Shock Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Recombinant Proteins; Signal Transduction

Topics: Cell Line; Cobalt; Gene Expression Regulation; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Biological; Mutation; Oxygen; Procollagen-Proline Dioxygenase; Proteasome Endopeptidase Complex; RNA Interference; RNA, Small Interfering; Von Hippel-Lindau Tumor Suppressor Protein

Topics: Animals; Animals, Newborn; Antimutagenic Agents; Astrocytes; Brain Ischemia; Cell Adhesion Molecules; Cell Shape; Cell Survival; Cells, Cultured; Cobalt; Glial Fibrillary Acidic Protein; Hypoxia; Mice; Reperfusion

Topics: Cell Line; Circadian Rhythm; Cobalt; DNA-Binding Proteins; Female; Gene Expression; Humans; Hypoxia; Nuclear Proteins; Oxygen; Period Circadian Proteins; Placenta; Placentation; Pregnancy; Transcription Factors; Trophoblasts; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A

Topics: Animals; Antioxidants; Cell Survival; Cells, Cultured; Chlorocebus aethiops; Chromans; Cobalt; COS Cells; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Space; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Hypoxia; Imidazoles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Superoxide Dismutase; Time Factors

Topics: Animals; Cell Hypoxia; Cell Survival; Cerebral Cortex; Cobalt; Dendrimers; Gene Knockdown Techniques; Genetic Therapy; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Silanes; Transfection

Topics: Animals; Antimutagenic Agents; Cobalt; Cytokines; Glutathione; Glutathione Disulfide; Heme Oxygenase-1; HSP70 Heat-Shock Proteins; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Ischemic Preconditioning; Lipid Peroxidation; Lung; Lung Injury; Male; Metallothionein; NF-E2-Related Factor 1; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Vascular Endothelial Growth Factor A

Topics: Animals; Brain Ischemia; Cell Line; Cobalt; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Interleukins; Male; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Stroke; Up-Regulation

Topics: Analysis of Variance; Animals; Antimutagenic Agents; Brain; Cell Death; Cobalt; Disease Models, Animal; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Nick-End Labeling; Lectins; Male; Microscopy, Electron, Transmission; Nerve Tissue Proteins; Neuroglia; Neurons; Rats; Rats, Wistar; Staining and Labeling; Time Factors

Topics: ADAM Proteins; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cobalt; Glaucoma; Hypoxia; Muscarinic Agonists; Rats; Receptors, Muscarinic; Retinal Ganglion Cells; RNA, Messenger

Topics: Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cell Line; Cobalt; Cytoprotection; Gene Products, tat; HSP27 Heat-Shock Proteins; Humans; Hypoxia; Mitochondria, Heart; Myocardium; Recombinant Fusion Proteins; Staurosporine; Transduction, Genetic

Topics: Animals; Aorta; Cobalt; Embryonic Stem Cells; Endothelium; Fibroblasts; Hypoxia; Melanoma, Experimental; Mice; Neoplasm Transplantation; Neovascularization, Pathologic; Receptors, Aryl Hydrocarbon; Recombination, Genetic; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A

Topics: Administration, Oral; Animals; Antimutagenic Agents; Body Weight; Cobalt; Dietary Supplements; Hypoxia; Ischemic Preconditioning; Lipid Peroxidation; Male; Organ Size; Rats; Rats, Sprague-Dawley

Topics: Adenocarcinoma; Antimutagenic Agents; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cobalt; Collagen; Drug Combinations; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Laminin; Matrix Metalloproteinases; Neoplasm Invasiveness; Proteoglycans; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinases

Topics: Adipocytes; Adipose Tissue; Antimutagenic Agents; Cells, Cultured; Cobalt; Female; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid; Monocarboxylic Acid Transporters; Muscle Proteins; Oxygen; Symporters; Syndrome

Topics: Animals; Cell Hypoxia; Cells, Cultured; Cobalt; Gene Expression Profiling; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lipopolysaccharides; Macrophages; Mice; Oxidative Stress; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Toll-Like Receptor 4; Up-Regulation

Topics: Analysis of Variance; Animals; Blotting, Western; Cattle; Cell Proliferation; Cells, Cultured; Cobalt; Corpus Luteum; Dose-Response Relationship, Drug; Endothelin-2; Female; Gene Expression Regulation; Gene Silencing; Gonadotropin-Releasing Hormone; Granulosa Cells; Hypoxia; Luteinizing Hormone; Ovarian Follicle; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Time Factors; Vascular Endothelial Growth Factor A

Topics: Aryl Hydrocarbon Hydroxylases; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Blotting, Western; Carcinogens; Cobalt; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; DNA Adducts; DNA Damage; Gene Expression Regulation, Neoplastic; Histones; Humans; Hypoxanthine Phosphoribosyltransferase; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoprecipitation; Inactivation, Metabolic; Lung Neoplasms; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

Topics: Animals; Cobalt; Hypoxia; Oxygen; Polycythemia; Rabbits

Topics: Amino Acid Sequence; Animals; Base Sequence; Cobalt; Flatfishes; Hypoxia; Molecular Sequence Data; PDZ Domains; Syntenins

Topics: Antigens, CD; Carcinoma, Squamous Cell; Cell Culture Techniques; Cells, Cultured; Cobalt; Collagen; Collagen Type IV; Culture Media; Cyclooxygenase 2; Fibroblasts; Humans; Hypoxia; Keratins; Laminin; Male; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Nerve Tissue Proteins; Proto-Oncogene Proteins c-met; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Tongue Neoplasms; Young Adult

Topics: Cell Line, Tumor; Cell Survival; Chromones; Cobalt; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Placenta; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Proto-Oncogene Proteins c-akt; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1

Topics: Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Cobalt; Electrophoresis, Polyacrylamide Gel; Epithelium, Corneal; Humans; Hydrogen Peroxide; Hypoxia; Immunohistochemistry; Mice; Mice, Knockout; Microscopy, Confocal; Organ Culture Techniques; Oxidative Stress; Protein Serine-Threonine Kinases; Wound Healing

Topics: Animals; Cell Movement; Cell Proliferation; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

Topics: Animals; Apoptosis; Astrocytes; Basic Helix-Loop-Helix Transcription Factors; Cell Culture Techniques; Cell Survival; Cerebral Cortex; Cobalt; Cyclooxygenase Inhibitors; Electron Transport Complex IV; Female; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Isoenzymes; Mesencephalon; Mice; Mice, Inbred BALB C; Necrosis; Potassium Cyanide; Reactive Oxygen Species; Sex Characteristics; Sodium Azide

Topics: Animals; Brefeldin A; Cell Line; Cobalt; Free Radicals; Hypoxia; Mast Cells; Mice; Mice, Mutant Strains; Proto-Oncogene Proteins c-fyn; R-SNARE Proteins; Tetanus Toxin; Vascular Endothelial Growth Factor A

Topics: Adult; Aged; Animals; Antimutagenic Agents; Body Weight; Cells, Cultured; Cobalt; Humans; Hypoxia; Male; Mice; Mice, Knockout; Middle Aged; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Myostatin; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Wistar; Recombinant Proteins; Signal Transduction; SKP Cullin F-Box Protein Ligases; Up-Regulation

Topics: Acclimatization; Animals; Cardiotonic Agents; Cobalt; DNA-Binding Proteins; Erythropoietin; Heart; Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Metallothionein; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Animals; Antioxidants; Apoptosis; Cell Hypoxia; Cobalt; Cytoprotection; Cytotoxins; Down-Regulation; Drug Evaluation, Preclinical; HSP90 Heat-Shock Proteins; Hydrogen Sulfide; Hypoxia; Membrane Potential, Mitochondrial; Neuroprotective Agents; PC12 Cells; Rats; Reactive Oxygen Species

Topics: Albumins; Altitude; Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cell Adhesion Molecules; Cobalt; Cytokines; DNA; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Hypoxia; Lung; Male; Metallothionein; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Vascular Endothelial Growth Factor A

Topics: Adult; Anterior Cruciate Ligament; Cells, Cultured; Cobalt; Drug Synergism; Fibroblasts; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Inflammation; Interleukin-1beta; Matrix Metalloproteinase 2; Middle Aged; NF-kappa B; Nitriles; Stress, Mechanical; Sulfones; Tumor Necrosis Factor-alpha; Young Adult

Topics: Animals; Annexins; Apoptosis; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Gene Expression Regulation; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; Hypoxia; Mice; Retina; Time Factors

Topics: Animals; Biomimetics; Cell Hypoxia; Cells, Cultured; Cobalt; Foot Diseases; Hoof and Claw; Horse Diseases; Horses; Hypoxia; Keratinocytes; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Up-Regulation

Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cobalt; Enzyme-Linked Immunosorbent Assay; Female; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunohistochemistry; Lignans; Luciferases; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms

Topics: Animals; Cadmium; Cardiotonic Agents; Cobalt; Guanidines; Heart; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemic Preconditioning, Myocardial; Male; Myocardium; Nitric Oxide Synthase Type II; Procollagen-Proline Dioxygenase; Rats; Rats, Wistar; Reperfusion Injury; Transcription Factors

Topics: Alkylation; Antineoplastic Agents, Alkylating; Azo Compounds; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Cyclams; DNA; Drug Screening Assays, Antitumor; Drug Stability; Female; Heterocyclic Compounds; Humans; Hypoxia; Indoles; Prodrugs; Solubility; Trace Elements

Topics: Blotting, Western; Cell Line, Tumor; Cell Survival; Cobalt; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Hydrogen Sulfide; Hypoxia; Interleukin-1beta; Interleukin-6; Interleukin-8; NF-kappa B; Nitrobenzenes; Proline; Reactive Oxygen Species; Signal Transduction; Sulfonamides; Thiocarbamates

Topics: Acetylcysteine; Animals; Apoptosis; Butyric Acid; Caspase 3; Cobalt; Diabetic Retinopathy; DNA Fragmentation; Down-Regulation; Free Radical Scavengers; Hypoxia; Pericytes; Rats; Reactive Oxygen Species; Retina; Superoxide Dismutase

Topics: Animals; Animals, Newborn; Cells, Cultured; Cobalt; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Eye Proteins; Guinea Pigs; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Nerve Growth Factors; Neuroglia; Rats; Retina; RNA, Messenger; RNA, Small Interfering; Serpins; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Adipocytes, White; Adipokines; Adipose Tissue, Brown; Animals; Antimutagenic Agents; Cells, Cultured; Cobalt; Deferoxamine; Hypoxia; Immunoblotting; Leptin; Mice; Siderophores

Topics: Adenoma; Animals; Cell Line, Tumor; Cobalt; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Neovascularization, Pathologic; Pituitary Neoplasms; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A

Topics: ADAM Proteins; ADAM17 Protein; Adult; Caspase 3; Cobalt; Dipeptides; Female; Heme Oxygenase-1; Humans; Hypoxia; Oxidative Stress; Placenta; Pre-Eclampsia; Pregnancy; RNA, Small Interfering; Trophoblasts; Tumor Necrosis Factor-alpha

Topics: Apoptosis; Cobalt; HEK293 Cells; Humans; Hypoxia; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Vascular Endothelial Growth Factor Receptor-2

Topics: Ampicillin; Anti-Bacterial Agents; Bacteria; Biocompatible Materials; Bone and Bones; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Cobalt; Drug Delivery Systems; Glass; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ions; Materials Testing; Mesenchymal Stem Cells; Middle Aged; Porosity; Tissue Engineering; Tissue Scaffolds; Vascular Endothelial Growth Factor A

Topics: Animals; Antimutagenic Agents; Cell Cycle Proteins; Cell Line; Choroidal Neovascularization; Cobalt; DNA, Complementary; Gene Expression; Genetic Therapy; Humans; Hypoxia; Rats; Retinal Pigment Epithelium; Vascular Endothelial Growth Factor A

Topics: Animals; Cell Line; Cells, Cultured; Cobalt; DNA, Complementary; Exenatide; Furin; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Peptides; Plasmids; Protein Processing, Post-Translational; Protein Sorting Signals; Protein Structure, Tertiary; Rats; Transfection; Vascular Endothelial Growth Factor A; Venoms

Topics: Animals; Antihypertensive Agents; Case-Control Studies; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Proliferation; Cells, Cultured; Cobalt; Cyclin B1; Disease Models, Animal; Dynamins; Enzyme Activation; Familial Primary Pulmonary Hypertension; Genetic Therapy; Glycolysis; GTP Phosphohydrolases; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microtubule-Associated Proteins; Mitochondria, Muscle; Mitochondrial Proteins; Mitosis; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pulmonary Artery; Quinazolinones; Rats; Rats, Sprague-Dawley; RNA Interference; Serine; Time Factors; Transfection

Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Line, Tumor; Cobalt; Colorectal Neoplasms; Gastrins; Gastrointestinal Neoplasms; Gastrointestinal Tract; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Biological; Promoter Regions, Genetic; RNA, Messenger; Sp1 Transcription Factor

Topics: Animals; Cell Line; Cobalt; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Gene Expression Regulation; Glucose; Glucose Transporter Type 1; Heme Oxygenase (Decyclizing); Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Tubules; Male; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Streptozocin; Time Factors; Vascular Endothelial Growth Factor A

Topics: Amino Acids, Dicarboxylic; Cell Line; Cobalt; Deferoxamine; Down-Regulation; Eukaryotic Initiation Factor-2; HEK293 Cells; Humans; Hydrogen Sulfide; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cells, Cultured; Cobalt; Cyclooxygenase 2; Disease Models, Animal; Electroretinography; Glial Fibrillary Acidic Protein; Hypoxia; Interleukin-1beta; Lutein; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroglia; NF-kappa B; Photic Stimulation; Rats; Reperfusion Injury; Retina; Retinal Diseases; Tumor Necrosis Factor-alpha

Topics: Aerobiosis; Animals; Cobalt; Energy Metabolism; Gene Expression Regulation; Hypoxia; Ischemic Preconditioning; Male; Mitochondrial Turnover; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase; Oxygen Consumption; Physical Endurance; Rats; Rats, Sprague-Dawley

Topics: Animals; Astragalus Plant; Cell Line, Tumor; Cobalt; Colonic Neoplasms; Cyclooxygenase 2; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Saponins; Signal Transduction; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A

Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cobalt; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Glycolysis; Hypoxia; Oligonucleotide Array Sequence Analysis; Rats; Signal Transduction; Up-Regulation

Topics: Animals; Cell Death; Cell Line; Cobalt; Curcumin; Endoplasmic Reticulum; Gene Expression Regulation; Hippocampus; Hypoxia; Mice; NF-kappa B; Oxidative Stress; Peptides; Peroxiredoxin VI; RNA, Messenger; Signal Transduction

Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cobalt; Dose-Response Relationship, Drug; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Ketoglutaric Acids; Ligases; Oxygen; Plasmids; Proline; Protein Biosynthesis; Protein Structure, Tertiary; Recombinant Fusion Proteins; Reticulocytes; Time Factors; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein

Topics: Amino Acids, Dicarboxylic; Animals; Chelating Agents; Cobalt; Deferoxamine; Fibroblasts; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Iron; Luciferases; Mice; Mice, Knockout; Proline; Protein Binding; Transcription Factors; Transfection

Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Base Sequence; Basic Helix-Loop-Helix Transcription Factors; Binding Sites; Cell Line; Cell Nucleus; Chondrocytes; Cobalt; Collagen; Cyclic AMP; DNA-Binding Proteins; HeLa Cells; Homeodomain Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Molecular Sequence Data; Oxidation-Reduction; Plasmids; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors; Transcription, Genetic; Transfection

Topics: 3T3 Cells; Animals; Cobalt; eIF-2 Kinase; Endoplasmic Reticulum; Enzyme Activation; Eukaryotic Initiation Factor-2; Fibroblasts; Gene Deletion; Genes, Dominant; HeLa Cells; Homozygote; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Kinetics; Methionine; Mice; Models, Biological; Oxygen; Phosphorylation; Plasmids; Protein Biosynthesis; Protein Folding; Proteins; Serine; Thapsigargin; Time Factors; Transcription Factors; Transfection

Topics: Animals; Animals, Newborn; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Glucose Transporter Type 1; Glucose Transporter Type 3; Hippocampus; Hypoxia; Neurons; Organometallic Compounds; Rats; Rats, Wistar; RNA, Messenger

Topics: Animals; Basic-Leucine Zipper Transcription Factors; Blotting, Northern; Blotting, Western; Cattle; Cell Line; Cobalt; Dactinomycin; Deferoxamine; Dimerization; Fanconi Anemia Complementation Group Proteins; Gene Expression Regulation; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypoxia; Interferon-gamma; Leucine Zippers; Luciferases; Membrane Proteins; Models, Genetic; Oxidative Stress; Oxygen; Promoter Regions, Genetic; Rats; RNA, Messenger; Time Factors; Transcription Factors; Transfection; Tumor Cells, Cultured

Topics: Animals; Chorionic Gonadotropin; Cobalt; Dose-Response Relationship, Drug; Drug Synergism; Female; Follicular Phase; Granulosa Cells; Hypoxia; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Macaca mulatta; Osmolar Concentration; Ovarian Follicle; Oxygen; Protein Isoforms; Vascular Endothelial Growth Factor A

Topics: Base Sequence; Cardiovascular System; Cell Hypoxia; Cells, Cultured; Cobalt; DNA Primers; Endothelium, Vascular; Feedback; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kinetics; Muscle, Smooth, Vascular; Myocardium; Procollagen-Proline Dioxygenase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors

Topics: Adolescent; Adult; Aged; Androgens; Angiogenesis Inhibitors; Animals; Blood Vessels; Castration; Cobalt; Eye Proteins; Humans; Hyperplasia; Hypoxia; In Situ Nick-End Labeling; Male; Mice; Mice, Knockout; Mice, Nude; Neoplasm Transplantation; Neovascularization, Physiologic; Nerve Growth Factors; Pancreas; Prostate; Prostatic Neoplasms; Proteins; Rats; Serpins; Tumor Cells, Cultured

Topics: Animals; Blotting, Western; Cobalt; Creatinine; DNA-Binding Proteins; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Ischemia; Kidney; Macrophages; Male; Nuclear Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors; Up-Regulation

Topics: Active Transport, Cell Nucleus; Androstadienes; Animals; Blotting, Western; Cell Line; Cell Nucleus; Cobalt; Endothelial Growth Factors; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genes, Reporter; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Ligases; Lymphokines; MAP Kinase Signaling System; Mice; Mice, Transgenic; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Viral Regulatory and Accessory Proteins; Von Hippel-Lindau Tumor Suppressor Protein; Wortmannin

Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Base Sequence; Blotting, Northern; Blotting, Western; Cell Line; Cell Nucleus; Chromones; Cobalt; Dimerization; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Genes, Dominant; Glutathione Transferase; Glycolysis; HeLa Cells; Humans; Hydrogen Peroxide; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Ligases; Luciferases; Mice; Molecular Sequence Data; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Pyrrolidines; Receptors, Aryl Hydrocarbon; RNA; Thiocarbamates; Time Factors; Transcription Factors; Transfection; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein

Topics: Animals; Blotting, Western; Cell Line, Tumor; Chick Embryo; Chorion; Cobalt; Enzyme-Linked Immunosorbent Assay; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microscopy, Video; Neovascularization, Pathologic; Prostatic Neoplasms; Rats; Time Factors; Transcription Factors; Tumor Suppressor Protein p53; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Cobalt; Hypoxia

Topics: Aircraft; Biomedical Research; Cobalt; Hypoxia; Wounds and Injuries

Topics: Anemia; Biological Assay; Cobalt; Epoetin Alfa; Erythropoietin; Humans; Hypophysectomy; Hypoxia; Oxygen; Starvation

Topics: Aging; Anemia; Bone Marrow Cells; Cobalt; Erythropoiesis; Hematocrit; Hemorrhage; Hypoxia; Physiology; Rats; Research

Topics: Altitude; Blood Volume; Cardiomegaly; Chlorides; Cobalt; Erythropoiesis; Heart; Hematocrit; Hypertrophy, Right Ventricular; Hypoxia; Mice; Physiology; Polycythemia; Rats; Research

Topics: Altitude; Animals; Cobalt; Cortisone; Disease Susceptibility; Endocarditis; Endocarditis, Bacterial; Hypoxia; Polycythemia; Polycythemia Vera; Rats

Topics: Amino Acid Transport System ASC; Cell Line; Cobalt; Computer Systems; Deferoxamine; Down-Regulation; Female; Gene Products, env; Humans; Hypoxia; In Vitro Techniques; Iron Chelating Agents; Minor Histocompatibility Antigens; Placenta; Polymerase Chain Reaction; Pregnancy; Pregnancy Proteins; RNA, Messenger; Transcription, Genetic; Trophoblasts

Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cobalt; Constitutive Androstane Receptor; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA-Binding Proteins; Hepatocytes; Hypoxia; Hypoxia-Inducible Factor 1; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Nuclear Proteins; Oligonucleotide Probes; Organometallic Compounds; Pregnane X Receptor; Protein Binding; Rabbits; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Transcription Factor AP-1; Transcription Factors; Up-Regulation

Topics: Activating Transcription Factor 4; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cobalt; Cysteine Endopeptidases; Deferoxamine; DNA-Binding Proteins; Electron Transport; Glucose; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Iron Chelating Agents; Mitochondria; Multienzyme Complexes; Mutation; Nuclear Proteins; Oxygen; Plasmids; Potassium Cyanide; Proteasome Endopeptidase Complex; Ribonucleases; RNA Interference; RNA, Messenger; Time Factors; Transcription Factor CHOP; Transcription Factors; Transfection; Tunicamycin

Topics: Animals; Cells, Cultured; Cobalt; Deferoxamine; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Enzymologic; Hypoxia; Mice; Muscle, Smooth, Vascular; Oxygen; Procollagen; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Procollagen-Proline Dioxygenase; Rats; RNA, Messenger

Topics: Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Chemokine CCL2; Cobalt; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Gene Expression Regulation; Humans; Hypoxia; Inflammation; Interleukin-1; Knee; Osteoarthritis; Polymerase Chain Reaction; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synovial Membrane; Time Factors

Topics: Angiopoietin-2; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Cobalt; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Deferoxamine; Dinoprostone; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Epoprostenol; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitory Concentration 50; Iron Chelating Agents; Isoenzymes; Lactones; Membrane Proteins; Nuclear Proteins; Oligonucleotides, Antisense; Oxygen; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Recombinant Proteins; RNA, Messenger; Sulfones; Time Factors; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Cobalt; Cornea; Environmental Pollutants; Genes, Reporter; Humans; Hypoxia; Isoenzymes; Mice; Mice, Transgenic; Organ Specificity; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Rabbits; Rats; Retinal Dehydrogenase

Topics: Basic Helix-Loop-Helix Transcription Factors; Cell Line; Cell Nucleus; Cobalt; Deferoxamine; Dimerization; DNA; Epithelial Cells; Genes, Dominant; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Lung; Oxygen; Promoter Regions, Genetic; Protein Biosynthesis; Protein Processing, Post-Translational; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases; RNA, Messenger; Time Factors; Trans-Activators; Transcription Factors; Transcription, Genetic

Topics: Actins; Animals; Antimutagenic Agents; Atmosphere Exposure Chambers; Cell Differentiation; Cell Line, Transformed; Cell Movement; Chronic Disease; Cobalt; Collagen Type I; Desmin; Epithelial Cells; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Tubules, Proximal; Phenotype; Rats; Transcription Factors; Vimentin

Topics: Autocrine Communication; Blotting, Western; Choroidal Neovascularization; Cobalt; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Pigment Epithelium of Eye; Recombinant Proteins; Time Factors; Transcription Factors; Vascular Endothelial Growth Factor A

Topics: Acetylcysteine; Androstadienes; Animals; Blotting, Western; Cell Nucleus; Chromones; Cobalt; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microscopy, Fluorescence; Models, Biological; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Plasmids; Potassium Chloride; Rabbits; Reactive Oxygen Species; Time Factors; Trachea; Transcription Factors; Transcription, Genetic; Transfection; Wortmannin

Topics: Ascorbic Acid; Blotting, Western; Carcinogens; Cell Line; Chromatography, High Pressure Liquid; Cobalt; Cysteine Endopeptidases; DNA-Binding Proteins; Dose-Response Relationship, Drug; Genes, Reporter; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Ketoglutaric Acids; Models, Biological; Multienzyme Complexes; Mutation; Nickel; Nuclear Proteins; Oxygen; Plasmids; Procollagen-Proline Dioxygenase; Proline; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Time Factors; Transcription Factors; Transcription, Genetic; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Up-Regulation; Von Hippel-Lindau Tumor Suppressor Protein

Topics: Adenocarcinoma; Animals; Carcinoma, Lewis Lung; Cobalt; DNA Damage; Ethylenediamines; Female; Hypoxia; Ligands; Lipid Peroxidation; Malondialdehyde; Mammary Neoplasms, Experimental; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Niacin; Niacinamide; Oxidation-Reduction; Pentanones

Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apigenin; Cell Line; Cobalt; Endothelial Cells; Endothelium, Vascular; Erythropoietin; Gene Expression Regulation; HSP90 Heat-Shock Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Transcription Factors; Vascular Endothelial Growth Factor A

Topics: Animals; Binding Sites; Biotinylation; Blotting, Western; Cell Hypoxia; Cell Line; Cell Proliferation; Cobalt; Deferoxamine; Enhancer Elements, Genetic; Fructosediphosphates; Gene Deletion; Gene Expression Regulation; Genes, Reporter; Glycine; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Luciferases; Mice; Models, Genetic; Oligonucleotides; Oxygen; Phosphofructokinase-2; Plasmids; Promoter Regions, Genetic; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Proteins; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Software; Time Factors; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Up-Regulation

Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Size; Cobalt; DNA Fragmentation; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nuclear Proteins; Rats; Transcription Factors

Topics: Blotting, Northern; Cell Line, Tumor; Cobalt; Deoxyglucose; Female; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Monosaccharide Transport Proteins; Oxygen; Pregnancy; Response Elements; RNA, Messenger; Transcription Factors; Trophoblasts

Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acute Disease; Animals; Barium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Carotid Body; Cells, Cultured; Cobalt; Hypoxia; Membrane Potentials; Nifedipine; Nitrogen; Oxygen; Patch-Clamp Techniques; Rats; Rats, Wistar

Topics: Antimutagenic Agents; Breast Neoplasms; Cobalt; DNA-Binding Proteins; Down-Regulation; Estrogen Receptor alpha; Female; Herpes Simplex Virus Protein Vmw65; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Nuclear Proteins; Protein Biosynthesis; Recombinant Fusion Proteins; Transcription Factors

Topics: Autoradiography; Cell Line, Tumor; Chromatin Immunoprecipitation; Cobalt; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Binding Proteins; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunoprecipitation; Luciferases; Male; Microscopy, Fluorescence; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Nuclear Proteins; Pancreatic Neoplasms; Phosphorylation; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Binding; RNA, Messenger; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Trans-Activators; Transcription Factors; Transcription, Genetic; Vascular Endothelial Growth Factor A

Topics: Blotting, Western; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Cobalt; Coloring Agents; Culture Media, Conditioned; Disease Progression; Dose-Response Relationship, Drug; Erythropoietin; Humans; Hypoxia; Immunohistochemistry; MAP Kinase Signaling System; Melanocytes; Melanoma; Membrane Potentials; Mitochondria; Phosphorylation; Receptors, Erythropoietin; Tetrazolium Salts; Thiazoles; Trypan Blue

Topics: Cell Line; Cell Proliferation; Cells, Cultured; Cobalt; Coloring Agents; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Gentian Violet; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoenzyme Techniques; In Vitro Techniques; Ions; Ki-67 Antigen; Microscopy, Fluorescence; Neovascularization, Pathologic; Oxygen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Software; Transcription Factors; Vascular Endothelial Growth Factor A

Topics: Algorithms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cobalt; Deferoxamine; DNA Primers; Down-Regulation; Erythrocytes; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Liver Neoplasms; Nickel; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Oligonucleotides; Oxygen; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Transcription, Genetic; Up-Regulation

Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Capillaries; Capillary Permeability; Cell Movement; Cell Proliferation; Cells, Cultured; Cobalt; Disease Models, Animal; Endothelial Cells; Epithelial Cells; Female; Hypoxia; Hypoxia-Inducible Factor 1; In Situ Nick-End Labeling; Kidney; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Neovascularization, Physiologic; Nephrectomy; Rats; Rats, Wistar; Vimentin

Topics: Adenoviridae; Animals; Aorta; Blotting, Western; Cattle; Cell Adhesion; Cell Movement; Cells, Cultured; Cobalt; DNA, Complementary; Endothelium, Vascular; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunoprecipitation; Luciferases; Microscopy, Fluorescence; Muscle, Smooth; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neovascularization, Pathologic; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transfection; Tyrosine; Vascular Endothelial Growth Factor A; Wound Healing

Topics: Animals; Antibodies; Antimutagenic Agents; Apoptosis; Capillaries; Cobalt; Erythropoietin; Gene Expression Regulation; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1; In Situ Nick-End Labeling; Isoantibodies; Kidney Tubules; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Reperfusion Injury; Vascular Endothelial Growth Factor A

Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Differentiation; Cell Survival; Cells, Cultured; Cobalt; Drug Resistance, Neoplasm; Esophageal Neoplasms; Esophagus; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Nick-End Labeling; Light; Photochemotherapy; Photosensitizing Agents; RNA, Small Interfering

Topics: Animals; Cells, Cultured; Cobalt; Disease Models, Animal; Down-Regulation; Hepatocyte Growth Factor; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA, Messenger

Topics: Cobalt; Crystallography, X-Ray; Electrochemistry; Hydrogen-Ion Concentration; Hydroxamic Acids; Hypoxia; Models, Chemical; Models, Molecular; Molecular Structure; Organometallic Compounds; Oxidation-Reduction; Prodrugs

Topics: Amino Acid Sequence; Cell Line, Tumor; Cobalt; Electron Transport Complex IV; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Metalloendopeptidases; Molecular Sequence Data; Oxidative Phosphorylation; Protein Subunits; Von Hippel-Lindau Tumor Suppressor Protein

Topics: Anti-Bacterial Agents; Cell Line; Cobalt; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunoblotting; Immunohistochemistry; Insulin-Like Growth Factor I; Ligands; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; RNA, Messenger; Signal Transduction; Sirolimus; Stimulation, Chemical; Transfection; Vascular Endothelial Growth Factor A

Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Awards and Prizes; bcl-2-Associated X Protein; Blotting, Western; Cardiopulmonary Bypass; Circulatory Arrest, Deep Hypothermia Induced; Cobalt; Deferoxamine; DNA Fragmentation; Gene Expression Regulation; Genes, bcl-2; Heart; Hypoxia; Hypoxia-Inducible Factor 1; In Situ Nick-End Labeling; Ischemic Preconditioning, Myocardial; Myocardium; Phosphorylation; Preanesthetic Medication; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Sus scrofa; Thoracic Surgery; United States

Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line; Cells, Cultured; Cisplatin; Cobalt; Cytoprotection; Electron Transport Complex III; Hypoxia; Hypoxia-Inducible Factor 1; Kidney Tubules; Mice; Mitochondria; Rats; Stem Cells; Tumor Suppressor Protein p53

Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Atorvastatin; CD55 Antigens; CD59 Antigens; Cells, Cultured; Cobalt; Cytoprotection; Deferoxamine; Diterpenes; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia; Iron Chelating Agents; Mevalonic Acid; Pyrroles; RNA, Messenger; Up-Regulation

Topics: Base Sequence; Cell Line, Transformed; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Chromones; Cobalt; Endothelial Cells; Endothelium, Vascular; Flavonoids; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Imidazoles; Interleukin-8; Molecular Sequence Data; Morpholines; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; RNA, Messenger

Topics: Amines; Animals; Antineoplastic Agents; Cobalt; Electrochemistry; Enzyme Inhibitors; Hydroxamic Acids; Hypoxia; Magnetic Resonance Spectroscopy; Matrix Metalloproteinase Inhibitors; Mice; Organometallic Compounds; Prodrugs; Pyridines; Time Factors; Tumor Cells, Cultured; X-Ray Diffraction

Topics: Aesculus; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Endothelium, Vascular; Escherichia coli; Escin; Fruit; Humans; Hypoxia; Inflammation; Interleukin-6; Lipopolysaccharides; Phytotherapy; Plant Extracts; Platelet Endothelial Cell Adhesion Molecule-1; Vascular Cell Adhesion Molecule-1

Topics: Animals; Biological Transport, Active; Cartilage, Articular; Cells, Cultured; Chondrocytes; Cobalt; Deoxyglucose; Horses; Hypoxia; Lactic Acid; Matrix Metalloproteinase 2; Molecular Mimicry

Topics: Animals; Apoptosis; Cats; Cobalt; Dose-Response Relationship, Drug; Free Radicals; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Muscle, Skeletal; Oxygen; Rats; Reactive Oxygen Species; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Animals; Antimutagenic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cobalt; Disease Models, Animal; Gene Expression; Glial Fibrillary Acidic Protein; Hypoxia; Male; Microscopy, Electron, Transmission; Neurons; Parietal Lobe; Phosphopyruvate Hydratase; Rats; Rats, Wistar

Topics: Adipocytes; Adipokines; Adiponectin; Adult; Angiopoietin-Like Protein 4; Angiopoietins; Cell Differentiation; Cells, Cultured; Cobalt; Female; Gene Expression Regulation; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-6; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Middle Aged; Plasminogen Activator Inhibitor 1; Vascular Endothelial Growth Factor A

Topics: Animals; Antimutagenic Agents; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cell Membrane; Cell Movement; Cobalt; Collagen; Enzyme Activation; Epithelium; Female; Green Fluorescent Proteins; Humans; Hypoxia; Mesoderm; Neoplasm Invasiveness; Neoplasm Metastasis; Oxygen; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Signal Transduction; Snail Family Transcription Factors; Transcription Factors

Topics: Antineoplastic Agents; Antiviral Agents; Chemistry, Pharmaceutical; Cobalt; Drug Carriers; Drug Delivery Systems; Drug Design; Drug Evaluation, Preclinical; Humans; Hypoxia; Ligands; Molecular Chaperones; Molecular Structure; Protein Binding; Structure-Activity Relationship

Topics: Animals; Cell Hypoxia; Cell Line; Cobalt; Hepatic Stellate Cells; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Matrix Metalloproteinase 2; Rats; RNA, Messenger

Topics: Animals; Antimutagenic Agents; Arginine; Basic Helix-Loop-Helix Transcription Factors; Blood Pressure; Blotting, Western; Chromatography, High Pressure Liquid; Cobalt; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Gene Expression; Glycation End Products, Advanced; Hypertension; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immediate-Early Proteins; Insulin-Like Growth Factor Binding Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Lysine; Male; NADPH Oxidases; Obesity; Oxidative Stress; Polymerase Chain Reaction; Rats; Rats, Inbred SHR; RNA, Messenger; Transforming Growth Factor beta

Topics: Amino Acids, Dicarboxylic; Base Sequence; Cells, Cultured; Cobalt; Deferoxamine; Dehydroepiandrosterone; DNA Primers; Enzyme Inhibitors; Estradiol; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Models, Cardiovascular; Myocytes, Smooth Muscle; Procollagen-Proline Dioxygenase; Pulmonary Artery; Testosterone

Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cobalt; Deferoxamine; Disease Models, Animal; Female; Hypoxia; Hypoxia-Ischemia, Brain; Male; Motor Skills; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Time Factors

Topics: Animals; Cobalt; Dogs; Erythropoietin; Hypoxia; Kidney; Perfusion

Topics: Animals; Cobalt; Erythropoiesis; Erythropoietin; Hypoxia; Kidney; Male; Rats; Rats, Inbred Strains

Topics: Animals; Animals, Newborn; Carbon Monoxide; Cells, Cultured; Cobalt; Erythropoietin; Gene Expression; Hypoxia; In Vitro Techniques; Liver; Male; Oxygen; Rats; Rats, Sprague-Dawley; RNA, Messenger

Topics: Base Sequence; Cell Hypoxia; Cobalt; DNA; Endothelial Growth Factors; Enhancer Elements, Genetic; Erythropoietin; Genes, Regulator; HeLa Cells; Humans; Hypoxia; Lymphokines; Molecular Sequence Data; Neovascularization, Pathologic; Sequence Homology, Nucleic Acid; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Animals; Cobalt; gamma-Aminobutyric Acid; Heart; Hypercapnia; Hypothalamus; Hypoxia; Male; Neurons; Rats; Rats, Sprague-Dawley; Respiration; Synaptic Transmission

Topics: Anemia; Animals; Cells, Cultured; Cobalt; Endothelial Growth Factors; Endothelium, Vascular; Fibroblasts; Gene Expression; Hypoxia; Isomerism; Lymphokines; Male; Nucleic Acid Hybridization; Rats; Rats, Wistar; Ribonucleases; RNA, Messenger; Tissue Distribution; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Animals; Blotting, Northern; Carotid Body; Cobalt; Electrophoresis, Polyacrylamide Gel; Hypoxia; Molecular Weight; Nerve Tissue Proteins; Rabbits; Reference Values; Superior Cervical Ganglion

Topics: Base Sequence; Binding Sites; Cell Line; Cobalt; DNA Primers; DNA-Binding Proteins; Enhancer Elements, Genetic; Erythropoietin; Gene Expression Regulation; Humans; Hypoxia; In Vitro Techniques; Molecular Sequence Data; Nuclear Proteins; Nucleic Acid Conformation; Oligonucleotides; Promoter Regions, Genetic; RNA, Messenger

Topics: Animals; Cobalt; Cycloheximide; Endothelial Growth Factors; Erythropoietin; Gene Expression Regulation; Genes, fos; Genes, jun; Heme; Humans; Hypoxia; In Vitro Techniques; Lymphokines; Oxygen; Rats; RNA, Messenger; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Anemia; Animals; Base Sequence; Cell Line; Chromatography, Affinity; Cobalt; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Gene Expression; Humans; Hypoxia; Kidney; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data

Topics: Base Sequence; Biphenyl Compounds; Cobalt; Deferoxamine; DNA-Binding Proteins; Enhancer Elements, Genetic; Erythropoietin; Gene Expression; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Onium Compounds; Oxygen; Transcription Factors; Tumor Cells, Cultured

Topics: Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Cobalt; Cycloheximide; DNA Primers; Endothelins; Endothelium, Vascular; Gene Expression Regulation; Humans; Hypoxia; Molecular Sequence Data; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate; Umbilical Arteries; Umbilical Veins

Topics: Administration, Cutaneous; Animals; Antimutagenic Agents; Cobalt; Gene Expression Regulation; Hypoxia; Male; Organ Specificity; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley

Topics: Animals; Base Sequence; Carbon Monoxide; Cobalt; Endothelial Growth Factors; Erythropoietin; Gene Expression Regulation; Hypoxia; In Vitro Techniques; Lymphokines; Male; Organ Specificity; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Animals; Autoradiography; Carbon Monoxide; Cobalt; Glyceraldehyde-3-Phosphate Dehydrogenases; Hypoxia; Liver; Lung; Male; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Ribonucleases; RNA, Messenger; Up-Regulation

Topics: Adult; Aging; Cobalt; Cohort Studies; Corpus Luteum; Endothelial Growth Factors; Female; Follicular Fluid; Granulosa Cells; Humans; Hypoxia; Lymphokines; Maternal Age; Middle Aged; Osmolar Concentration; Ovulation Induction; Pregnancy; Pregnancy, High-Risk; Retrospective Studies; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Adrenomedullin; Cobalt; Colorectal Neoplasms; Culture Media; Gene Expression Regulation; Humans; Hypoxia; Ischemia; Peptides; RNA, Messenger; Tumor Cells, Cultured; Vasodilator Agents

Topics: Altitude Sickness; Animals; Blood Gas Analysis; Blotting, Northern; Chronic Disease; Cobalt; Erythropoietin; Feedback; Gene Expression Regulation; Hypoxia; Kidney; Kidney Function Tests; Male; Polycythemia; Rats; Rats, Sprague-Dawley; Ribonucleases

Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Carbon Monoxide; Cell Adhesion; Cell Movement; Cells, Cultured; Cobalt; DNA-Binding Proteins; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Precursors; Gelatinases; Gene Expression Regulation; Hemeproteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Lymphokines; Nuclear Proteins; Plasminogen Activators; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Transcription Factors; Urokinase-Type Plasminogen Activator; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: 2-Amino-5-phosphonovalerate; Animals; Benzoates; Cell Membrane; Cobalt; Glucose; Hemoglobins; Hippocampus; Hypoxia; Imidazoles; In Vitro Techniques; Ischemic Attack, Transient; Male; Membrane Potentials; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pyramidal Cells; Rats; Rats, Wistar; Reaction Time; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase

Topics: Animals; Antimutagenic Agents; Antioxidants; Aortic Bodies; Barium; Calcium Channel Blockers; Carotid Body; Cobalt; Electric Stimulation; Hypoxia; Ion Channel Gating; Membrane Potentials; Mice; Microelectrodes; Patch-Clamp Techniques; Sodium; Tetrodotoxin; Thiosulfates

Topics: Animals; Axons; Carotid Body; Chemoreceptor Cells; Cobalt; Electric Stimulation; Evoked Potentials; Hypoxia; In Vitro Techniques; Nerve Fibers; Neural Conduction; Poisson Distribution; Rats; Saline Solution, Hypertonic; Sodium; Tetrodotoxin

Topics: Animals; Arginine; Butyrates; Cattle; Cells, Cultured; Cobalt; Cycloheximide; Dactinomycin; Endothelium, Vascular; Gene Expression Regulation; Humans; Hydroxamic Acids; Hypoxia; NG-Nitroarginine Methyl Ester; Oxygen; RNA, Messenger; Thrombospondin 1

Topics: Animals; Antimutagenic Agents; Blood-Brain Barrier; Brain Chemistry; Capillaries; Cerebral Cortex; Cobalt; Endothelial Growth Factors; Gene Expression; Glucose Transporter Type 1; Glucose Transporter Type 3; Hypoxia; Lymphokines; Male; Microcirculation; Monosaccharide Transport Proteins; Nerve Tissue Proteins; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Retina; Retinal Vessels; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Adult; Anemia, Sickle Cell; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Movement; Cells, Cultured; Cobalt; E-Selectin; Endothelium, Vascular; Enzyme Inhibitors; Erythrocytes, Abnormal; Flavonoids; HL-60 Cells; Humans; Hypoxia; Indoles; Intercellular Adhesion Molecule-1; Maleimides; Marine Toxins; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; NF-kappa B; Oxazoles; Phospholipid Ethers; Phosphoprotein Phosphatases; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Platelet Membrane Glycoproteins; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Umbilical Veins; Vascular Cell Adhesion Molecule-1

Topics: Age Factors; Animals; Calcium; Cell Size; Cobalt; Fluorescent Dyes; Hypothalamus; Hypoxia; Hypoxia, Brain; Isoquinolines; Membrane Potentials; Neurons; Oxygen; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Tetrodotoxin

Topics: Animals; Antineoplastic Agents; Chelating Agents; Cobalt; Cricetinae; Cricetulus; DNA; Electrochemistry; Growth Inhibitors; Hypoxia; Intercalating Agents; Kinetics; Mice; Nuclear Magnetic Resonance, Biomolecular; Organometallic Compounds; Phenazines

Topics: Animals; Cell Line; Cobalt; Cycloheximide; Dactinomycin; Dexamethasone; Dose-Response Relationship, Drug; Endothelial Growth Factors; Glucocorticoids; Hyperoxia; Hypoxia; Lymphokines; Mice; Nickel; Nucleic Acid Synthesis Inhibitors; Osteoblasts; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Androstadienes; Animals; Cell Line; Cell Nucleus; Chelating Agents; Cobalt; Cytosol; Deferoxamine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electron Transport Complex III; Electron Transport Complex IV; Enzyme Inhibitors; Genes, Reporter; Humans; Hydrogen Peroxide; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Marine Toxins; Mitochondria; Mitochondria, Liver; Models, Biological; Nuclear Proteins; Oxazoles; Oxidation-Reduction; Oxygen; Paracoccus denitrificans; Rats; Reactive Oxygen Species; Time Factors; Transcription Factors; Transfection; Tumor Cells, Cultured; Wortmannin

Topics: Adaptation, Physiological; Animals; Antimutagenic Agents; Cobalt; Coronary Circulation; Dose-Response Relationship, Drug; Energy Metabolism; Glycogen; Heart; Hematocrit; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Organ Size; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Ventricular Pressure

Topics: Cadmium; Cell Survival; Cisplatin; Cobalt; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Environmental Exposure; Erythropoietin; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mercury; Metals, Heavy; Nuclear Proteins; Protein Binding; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured; Zinc

Topics: Animals; Cobalt; Computer Systems; Corpus Striatum; Dialysis; Dicarboxylic Acids; Electrodes; Extracellular Space; Glutamic Acid; Hypoxia; Ions; Male; Microinjections; omega-Conotoxin GVIA; Oxygen; Potassium; Potassium Chloride; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium

Topics: Actins; Antimutagenic Agents; Cell Division; Cell Hypoxia; Cell Size; Cell Survival; Cells, Cultured; Chelating Agents; Cobalt; Collagen; Collagenases; Culture Media, Conditioned; Deferoxamine; Extracellular Matrix; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Hypoxia; Kidney Cortex; Kidney Failure, Chronic; Oxygen; Promoter Regions, Genetic; Protein Kinase C; Protein-Tyrosine Kinases; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Transcription, Genetic; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1

Topics: Base Sequence; beta-Galactosidase; Blotting, Northern; Chelating Agents; Cobalt; DNA Mutational Analysis; DNA-Binding Proteins; Fatty Acid Desaturases; Fatty Acids; Gene Deletion; Genes, Reporter; Hypoxia; Iron; Lac Operon; Molecular Sequence Data; Oxygen; Phenanthrolines; Plasmids; Promoter Regions, Genetic; Recombinant Fusion Proteins; Repressor Proteins; Response Elements; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Signal Transduction; Stearoyl-CoA Desaturase; Transcriptional Activation; Up-Regulation

Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Antibodies, Monoclonal; Antimutagenic Agents; Apoptosis; Blotting, Northern; Cell Line; Cell Nucleus; Cells, Cultured; Chelating Agents; Cobalt; Dactinomycin; Deferoxamine; DNA-Binding Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Inhibitor of Apoptosis Proteins; Kidney; Mice; Models, Biological; Nuclear Proteins; Oxidation-Reduction; Oxygen; Protein Synthesis Inhibitors; Proteins; Rats; Stem Cells; Transcription Factors; Transcription, Genetic; Up-Regulation

Topics: Animals; Carboxy-Lyases; Carnitine O-Palmitoyltransferase; Cobalt; Down-Regulation; Energy Metabolism; Gene Expression; Heart; Hemodilution; Hypoxia; Isoenzymes; Male; Myocardium; Oxygen; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Transcription Factors

Topics: Animals; Blotting, Northern; Blotting, Western; Calcium; Cell Cycle Proteins; Cell Nucleus; Cobalt; Deferoxamine; DNA, Complementary; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Flavonoids; Gene Library; Hypoxia; Imidazoles; Immediate-Early Proteins; Mitogen-Activated Protein Kinases; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphoprotein Phosphatases; Polymerase Chain Reaction; Potassium Chloride; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Pyridines; Rats; RNA, Messenger; Signal Transduction; Time Factors; Up-Regulation

Topics: Cobalt; Hypoxia; Manganese; Particle Size; Proteobacteria; RNA; Solubility; Water Microbiology

Topics: Acetylcysteine; Blotting, Western; Calcitriol; Cell Line; Cobalt; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Growth Factors; Free Radical Scavengers; Gene Expression; Glucocorticoids; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Lymphokines; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Adult; Chorionic Villi; Cobalt; Deferoxamine; Drug Combinations; Enzyme Inhibitors; Female; Ferrous Compounds; Hemeproteins; Humans; Hypoxia; Iron Chelating Agents; Mitochondria; Onium Compounds; Organ Culture Techniques; Oxygen; Oxygen Consumption; Pregnancy; Pregnancy Trimester, First; Rotenone; Trophoblasts; Uncoupling Agents

Topics: Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Cobalt; Cyclic AMP Response Element-Binding Protein; Deferoxamine; DNA, Complementary; Electrophoretic Mobility Shift Assay; Enhancer Elements, Genetic; Gene Expression Regulation; Humans; Hypoxia; Inhibitor of Apoptosis Proteins; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; Rats; RNA, Messenger; Sequence Deletion; Sequence Homology, Amino Acid; Sp1 Transcription Factor; Viral Proteins

Topics: Amino Acid Sequence; Asparagine; Biological Evolution; Cloning, Molecular; Cobalt; DNA-Binding Proteins; Humans; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Ketoglutaric Acids; Mannose-6-Phosphate Isomerase; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Nuclear Proteins; Peptide Fragments; Protein Conformation; Repressor Proteins; Sequence Alignment; Spectrometry, Mass, Electrospray Ionization; Transcription Factors; Transcriptional Activation; Yeasts; Zinc

Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Carbon Monoxide; Cobalt; DNA-Binding Proteins; Gene Expression; Glucose Transporter Type 1; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemia; Kidney; Male; Monosaccharide Transport Proteins; Nuclear Proteins; Oxygen; Phlebotomy; Protein Isoforms; Rats; Rats, Sprague-Dawley; Renal Circulation; Staining and Labeling; Trans-Activators; Transcription Factors

Topics: Blotting, Western; Cell Line; Cobalt; DNA Fragmentation; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ketoglutaric Acids; Luciferases; Nitric Oxide; Oxygen; Procollagen-Proline Dioxygenase; Protein Binding; Protein Structure, Tertiary; Sepharose; Signal Transduction; Sodium Chloride; Time Factors; Transcription Factors; Transcription, Genetic; Transfection

Topics: Acetylcholinesterase; Acid-Base Equilibrium; Anemia; Animals; Chlorides; Cobalt; Erythrocytes; Female; Hemorrhage; Hydrochloric Acid; Hydrogen-Ion Concentration; Hypoxia; Lactates; Male; Partial Pressure; Rabbits

Topics: Adenylyl Cyclases; Animals; Cobalt; Cyclic AMP; Erythropoiesis; Fluorides; Hypoxia; Kidney; Kidney Cortex; Kidney Medulla; Lactates; Parathyroid Hormone; Rats

Topics: Animals; Bicarbonates; Blood Pressure; Carbon Dioxide; Cardiac Output; Cobalt; Dogs; Female; Hydrogen-Ion Concentration; Hypoxia; Lactates; Male; Oxygen; Oxygen Consumption; Propranolol; Pyruvates; Time Factors

Topics: Altitude Sickness; Animals; Blood Transfusion; Cobalt; Diphosphoglyceric Acids; Disease Models, Animal; Erythrocytes; Female; Hematocrit; Hemoglobinometry; Hemoglobins; Hypoxia; Male; Splenectomy

Topics: Animals; Azathioprine; Blood Pressure; Cobalt; Diet; Dogs; Erythropoietin; Female; Graft Rejection; Hypoxia; Juxtaglomerular Apparatus; Kidney Transplantation; Male; Renin; Sodium Chloride; Testosterone; Transplantation, Homologous

Topics: Animals; Bloodletting; Carbon Monoxide Poisoning; Cobalt; Erythropoietin; Female; Guinea Pigs; Hypoxia; Kidney; Mice; Nephrectomy; Rats; Species Specificity

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Carcinoma, Hepatocellular; Cobalt; Colforsin; Cyclic AMP; Erythropoietin; Humans; Hypoxia; Liver Neoplasms; Tumor Cells, Cultured

Topics: Animals; Cell Line; Chlorocebus aethiops; Cobalt; Erythropoietin; Gene Expression Regulation; Humans; Hypoxia; In Vitro Techniques; Regulatory Sequences, Nucleic Acid; Transcription, Genetic; Transfection

Topics: Animals; Calcium; Carotid Body; Cats; Chemoreceptor Cells; Cobalt; Electrophysiology; Erythropoietin; Hypoxia; Oxygen

Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cobalt; Cricetinae; Erythropoietin; Glycosylation; Humans; Hypoxia; Liver Neoplasms; Protein Processing, Post-Translational; RNA, Messenger; Transfection; Tumor Cells, Cultured; Tunicamycin

Topics: Animals; Cobalt; Erythropoietin; Gene Expression Regulation; Hypoxia; Kidney; Male; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic

Topics: Animals; Bepridil; Calcium Channel Blockers; Cells, Cultured; Cobalt; Diltiazem; Dinoprostone; Epoprostenol; Fibroblasts; Glycogen; Heart; Hypoxia; Myocardium; Prostaglandins E; Pyrrolidines; Rats; Rats, Inbred Strains; Verapamil

Topics: Animals; Ascorbic Acid; Biological Transport; Cobalt; Duodenum; Ferrous Compounds; Hydrogen-Ion Concentration; Hypoxia; Intestinal Absorption; Intestinal Mucosa; Iron; Iron Radioisotopes; Kinetics; Male; Manganese; Mice; Microvilli; Sodium Chloride

Topics: Animals; Cell Line; Cell Survival; Cobalt; Dose-Response Relationship, Radiation; Hypoxia; Iron; Male; Mice; Radiation-Sensitizing Agents; Sarcoma, Experimental; Structure-Activity Relationship; X-Rays

Topics: Animals; Ascorbic Acid; Cobalt; Ferrous Compounds; Hypoxia; Intestines; Iron; Manganese; Mice; Microvilli

Topics: Animals; Cobalt; Depression, Chemical; Erythropoiesis; Hypoxia; Male; Oxygen Consumption; Rats; Stimulation, Chemical; Temperature

Topics: Alpha-Globulins; Androgens; Animals; Biological Assay; Cobalt; Erythrocytes; Erythropoietin; Hematocrit; Hypothalamus; Hypoxia; Iron Isotopes; Kidney; Liver; Oxygen; Rabbits; Rats

Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Carbon Isotopes; Cobalt; Coenzyme A; Edetic Acid; Glycogen; Hot Temperature; Hypoxia; Kinetics; Magnesium; Manganese; Myocardium; NAD; Nucleotidases; Protein Denaturation; Rats; Spectrophotometry

Topics: Animals; Butyrates; Cobalt; Cyclic AMP; Erythropoiesis; Erythropoietin; Hypoxia; Iron; Iron Isotopes; Kidney; Male; Polycythemia; Rats; Stimulation, Chemical

Topics: Adenylyl Cyclases; Animals; Cobalt; Cyclic AMP; Erythropoiesis; Erythropoietin; Hypoxia; Iron; Iron Radioisotopes; Kidney Cortex; Kidney Medulla; Lactates; Male; NAD; Phosphorus Radioisotopes; Polycythemia; Pyruvates; Rats; Spectrophotometry, Ultraviolet; Stimulation, Chemical; Time Factors; Tritium

Topics: Acid Phosphatase; Animals; Cobalt; Erythropoiesis; Erythropoietin; Female; Glucuronidase; Histocytochemistry; Hypoxia; Iron; Kidney; Lysosomes; Male; Manganese; Membranes; Mice; Microscopy, Electron; Mitochondria; Nephrectomy; Nickel; Polycythemia; Rats

Topics: Animals; Arteries; Blood Pressure; Cardiac Output; Chemoreceptor Cells; Cobalt; Cyanides; Female; Hydrogen-Ion Concentration; Hypoxia; Indicator Dilution Techniques; Male; Oxygen Consumption; Pressoreceptors; Rats

Topics: Administration, Oral; Altitude; Animals; Chlorides; Cobalt; Erythrocyte Count; Histidine; Hypoxia; Kidney; Liver; Male; Muscles; Polycythemia; Rats; Spleen; Time Factors

Topics: Animals; Arsenic; Biological Assay; Cobalt; Erythropoietin; Female; Hypoxia; Iron; Iron Isotopes; Male; Methylene Blue; Mice; Polycythemia; Rabbits; Stimulation, Chemical; Triazoles; Zinc

Topics: Animals; Cobalt; Dogs; Erythropoietin; Female; Hemorrhage; Hypoxia; Iron Isotopes; Kidney; Kidney Transplantation; Male; Mice; Testosterone; Transplantation, Autologous

Topics: Androgens; Animals; Azathioprine; Blood Urea Nitrogen; Cobalt; Dogs; Erythropoiesis; Erythropoietin; Female; Hematocrit; Hypoxia; Immunosuppressive Agents; Kidney Transplantation; Leukocyte Count; Male; Tissue Extracts; Urination

Topics: Cardiovascular Diseases; Cobalt; Ethanol; Heart; Humans; Hypoxia; Myocardium; Salicylates

Topics: Animals; Biological Assay; Cobalt; Dogs; Erythrocytes; Erythropoietin; Female; Hypoxia; Iron; Iron Isotopes; Kidney; Kidney Glomerulus; Male; Mice; Oximetry; Oxygen; Perfusion; Testosterone

Topics: Animals; Chlorides; Cobalt; Erythropoietin; Hypoxia; Injections, Intraperitoneal; Oxygen Consumption; Polythiazide; Rats; Renin; Sodium Chloride; Water-Electrolyte Balance

Topics: Animals; Biological Assay; Blood Volume; Body Weight; Cobalt; Erythropoietin; Female; Hypoxia; Iron Isotopes; Kidney; Nephrectomy; Rats; Testosterone

Topics: Animals; Cobalt; Hypoxia; Methemoglobinemia; Methylcholanthrene; Mice; Nitrites; Sodium

Topics: Anemia; Animals; Brain; Cerebrospinal Fluid; Cobalt; Electrophoresis; Hypoxia; Isoenzymes; Kidney; L-Lactate Dehydrogenase; Liver; Muscles; Myocardium; Rabbits