clozapine-n-oxide and Carcinoma--Lewis-Lung

clozapine-n-oxide has been researched along with Carcinoma--Lewis-Lung* in 2 studies

Other Studies

2 other study(ies) available for clozapine-n-oxide and Carcinoma--Lewis-Lung

Article	Year
Modulation of anti-tumor immunity by the brain's reward system. Nature communications, 2018, 07-13, Volume: 9, Issue:1 Regulating immunity is a leading target for cancer therapy. Here, we show that the anti-tumor immune response can be modulated by the brain's reward system, a key circuitry in emotional processes. Activation of the reward system in tumor-bearing mice (Lewis lung carcinoma (LLC) and B16 melanoma) using chemogenetics (DREADDs), resulted in reduced tumor weight. This effect was mediated via the sympathetic nervous system (SNS), manifested by an attenuated noradrenergic input to a major immunological site, the bone marrow. Myeloid derived suppressor cells (MDSCs), which develop in the bone marrow, became less immunosuppressive following reward system activation. By depleting or adoptively transferring the MDSCs, we demonstrated that these cells are both necessary and sufficient to mediate reward system effects on tumor growth. Given the central role of the reward system in positive emotions, these findings introduce a physiological mechanism whereby the patient's psychological state can impact anti-tumor immunity and cancer progression. Topics: Adrenergic Neurons; Animals; Bone Marrow Cells; Carcinoma, Lewis Lung; Clozapine; Dopamine; Dopaminergic Neurons; Immunity, Innate; Immunologic Factors; Injections, Intraventricular; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloid-Derived Suppressor Cells; Norepinephrine; Reward; Stereotaxic Techniques; Sympathetic Nervous System; Tumor Burden; Ventral Tegmental Area	2018
Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus. Nature neuroscience, 2017, Volume: 20, Issue:7 Anorexia is a common manifestation of chronic diseases, including cancer. Here we investigate the contribution to cancer anorexia made by calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) that transmit anorexic signals. We show that CGRP Topics: Adenomatous Polyposis Coli Protein; Animals; Anorexia; Behavior, Animal; Body Weight; Cachexia; Calcitonin Gene-Related Peptide; Carcinoma, Lewis Lung; Clozapine; Energy Metabolism; Female; Illness Behavior; Male; Metalloendopeptidases; Mice; Mice, Transgenic; Neoplasms; Parabrachial Nucleus; Tetanus Toxin; Tumor Cells, Cultured	2017

Article

Year

Modulation of anti-tumor immunity by the brain's reward system.

Nature communications, 2018, 07-13, Volume: 9, Issue:1

Regulating immunity is a leading target for cancer therapy. Here, we show that the anti-tumor immune response can be modulated by the brain's reward system, a key circuitry in emotional processes. Activation of the reward system in tumor-bearing mice (Lewis lung carcinoma (LLC) and B16 melanoma) using chemogenetics (DREADDs), resulted in reduced tumor weight. This effect was mediated via the sympathetic nervous system (SNS), manifested by an attenuated noradrenergic input to a major immunological site, the bone marrow. Myeloid derived suppressor cells (MDSCs), which develop in the bone marrow, became less immunosuppressive following reward system activation. By depleting or adoptively transferring the MDSCs, we demonstrated that these cells are both necessary and sufficient to mediate reward system effects on tumor growth. Given the central role of the reward system in positive emotions, these findings introduce a physiological mechanism whereby the patient's psychological state can impact anti-tumor immunity and cancer progression.

Topics: Adrenergic Neurons; Animals; Bone Marrow Cells; Carcinoma, Lewis Lung; Clozapine; Dopamine; Dopaminergic Neurons; Immunity, Innate; Immunologic Factors; Injections, Intraventricular; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloid-Derived Suppressor Cells; Norepinephrine; Reward; Stereotaxic Techniques; Sympathetic Nervous System; Tumor Burden; Ventral Tegmental Area

2018

Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus.

Nature neuroscience, 2017, Volume: 20, Issue:7

Anorexia is a common manifestation of chronic diseases, including cancer. Here we investigate the contribution to cancer anorexia made by calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) that transmit anorexic signals. We show that CGRP

Topics: Adenomatous Polyposis Coli Protein; Animals; Anorexia; Behavior, Animal; Body Weight; Cachexia; Calcitonin Gene-Related Peptide; Carcinoma, Lewis Lung; Clozapine; Energy Metabolism; Female; Illness Behavior; Male; Metalloendopeptidases; Mice; Mice, Transgenic; Neoplasms; Parabrachial Nucleus; Tetanus Toxin; Tumor Cells, Cultured

2017