clozapine and Testicular-Neoplasms

Topics: Adult; Antineoplastic Agents; Antipsychotic Agents; Bleomycin; Breast Neoplasms; Carcinoma; Cisplatin; Clozapine; Etoposide; Female; Humans; Intestinal Neoplasms; Male; Middle Aged; Neoplasms; Neutropenia; Schizophrenia; Seminoma; Testicular Neoplasms

A 40-year-old chronic schizophrenic patient whose psychosis and associated violent behaviour resolved on clozapine, required chemotherapy for a testicular teratoma with pulmonary metastases. His treatment was initially delayed due to refusal to consent.. The patient finally agreed to orchidectomy and cytotoxic therapy, and following agreement by the CPMS, clozapine continued to be dispensed despite neutropenia and 'red alert' status on full blood count.. This is the only patient to continue clozapine despite 'red alert' status, and as such is an exceptional case, but may open the way for such patients in the future.

Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Antipsychotic Agents; Chemotherapy, Adjuvant; Clozapine; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Male; Neutropenia; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Teratoma; Testicular Neoplasms; Treatment Refusal; Violence