clozapine and Syncope

clozapine has been researched along with Syncope* in 6 studies

Trials

1 trial(s) available for clozapine and Syncope

Article	Year
Significant interaction between clozapine and cocaine in cocaine addicts. Drug and alcohol dependence, 2000, May-01, Volume: 59, Issue:2 Because clozapine may be prescribed to cocaine abusing patients with schizophrenia, we studied cocaine-clozapine interactions in a controlled setting. Eight male cocaine addicts underwent four oral challenges with ascending doses of clozapine (12.5, 25 and 50 mg) and placebo followed 2 h later by a 2-mg/kg dose of intranasal cocaine. Subjective and physiological responses, and serum cocaine levels were measured over a total 4-h period. Clozapine pretreatment increased cocaine levels during the study and significantly increased the peak serum cocaine levels in a dose dependent manner. In spite of this elevation in blood levels, clozapine pretreatment had a significant diminishing effect upon subjective responses to cocaine, including 'expected high', 'high' and 'rush', notably at the 50 mg dose. There was also a significant effect upon 'sleepiness', 'paranoia' and 'nervous'. Clozapine caused a significant near-syncopal episode in one subject in the study, requiring his removal from the study. Clozapine had no significant effect on baseline pulse rate and systolic blood pressure, but it attenuated the significant pressor effects of the single dose of intranasal cocaine. These data suggested a possible therapeutic role for clozapine in the treatment of cocaine addiction in humans, but also suggests caution due to the near-syncopal event and the increase in serum cocaine levels. Topics: Adult; Arousal; Clozapine; Cocaine; Cocaine-Related Disorders; Comorbidity; Dose-Response Relationship, Drug; Drug Interactions; Euphoria; Humans; Male; Risk Factors; Schizophrenia; Syncope	2000

Article

Year

Significant interaction between clozapine and cocaine in cocaine addicts.

Drug and alcohol dependence, 2000, May-01, Volume: 59, Issue:2

Because clozapine may be prescribed to cocaine abusing patients with schizophrenia, we studied cocaine-clozapine interactions in a controlled setting. Eight male cocaine addicts underwent four oral challenges with ascending doses of clozapine (12.5, 25 and 50 mg) and placebo followed 2 h later by a 2-mg/kg dose of intranasal cocaine. Subjective and physiological responses, and serum cocaine levels were measured over a total 4-h period. Clozapine pretreatment increased cocaine levels during the study and significantly increased the peak serum cocaine levels in a dose dependent manner. In spite of this elevation in blood levels, clozapine pretreatment had a significant diminishing effect upon subjective responses to cocaine, including 'expected high', 'high' and 'rush', notably at the 50 mg dose. There was also a significant effect upon 'sleepiness', 'paranoia' and 'nervous'. Clozapine caused a significant near-syncopal episode in one subject in the study, requiring his removal from the study. Clozapine had no significant effect on baseline pulse rate and systolic blood pressure, but it attenuated the significant pressor effects of the single dose of intranasal cocaine. These data suggested a possible therapeutic role for clozapine in the treatment of cocaine addiction in humans, but also suggests caution due to the near-syncopal event and the increase in serum cocaine levels.

Topics: Adult; Arousal; Clozapine; Cocaine; Cocaine-Related Disorders; Comorbidity; Dose-Response Relationship, Drug; Drug Interactions; Euphoria; Humans; Male; Risk Factors; Schizophrenia; Syncope

2000

Other Studies

5 other study(ies) available for clozapine and Syncope

Article	Year
Cardiac risk at the onset of treatment in patients treated with benzodiazepines and clozapine. European psychiatry : the journal of the Association of European Psychiatrists, 2002, Volume: 17, Issue:7 Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Heart Arrest; Humans; Male; Psychotic Disorders; Schizophrenia, Paranoid; Syncope	2002
Transient syncope and ECG changes associated with the concurrent administration of clozapine and diazepam. The Journal of clinical psychiatry, 1999, Volume: 60, Issue:9 Topics: Anti-Anxiety Agents; Antipsychotic Agents; Bradycardia; Clozapine; Diazepam; Drug Interactions; Drug Therapy, Combination; Electrocardiography; Humans; Male; Middle Aged; Schizophrenia, Paranoid; Syncope	1999
ST segment elevations without myocardial infarction in a patient on clozapine. The American journal of emergency medicine, 1996, Volume: 14, Issue:1 Topics: Antipsychotic Agents; Arrhythmias, Cardiac; Clozapine; Electrocardiography; Humans; Male; Middle Aged; Myocardial Infarction; Syncope	1996
Near syncope associated with concomitant clozapine and cocaine use. The Journal of clinical psychiatry, 1996, Volume: 57, Issue:8 Topics: Administration, Intranasal; Adult; Blood Pressure; Clozapine; Cocaine; Drug Interactions; Heart Rate; Humans; Male; Schizophrenia; Substance-Related Disorders; Syncope	1996
Syncope associated with the combination of clozapine and enalapril. Journal of clinical psychopharmacology, 1994, Volume: 14, Issue:6 Topics: Adult; Blood Pressure; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Enalapril; Humans; Hypertension; Male; Psychotic Disorders; Resuscitation; Syncope	1994