clozapine and Starvation

Mammalian reproductive function depends upon a neuroendocrine circuit that evokes the pulsatile release of gonadotropin hormones (luteinizing hormone and follicle-stimulating hormone) from the pituitary. This reproductive circuit is sensitive to metabolic perturbations. When challenged with starvation, insufficient energy reserves attenuate gonadotropin release, leading to infertility. The reproductive neuroendocrine circuit is well established, composed of two populations of kisspeptin-expressing neurons (located in the anteroventral periventricular hypothalamus, Kiss1

Topics: Agouti-Related Protein; Animals; Circadian Clocks; Clozapine; Estrous Cycle; Female; Fertility; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Hypothalamus; Kisspeptins; Leptin; Luteinizing Hormone; Male; Mice; Mice, Transgenic; Neurons; Optogenetics; Reproduction; Signal Transduction; Starvation; Stereotaxic Techniques