clozapine and Remission--Spontaneous

We present a case study of the remission of a chemically resistant schizophrenia disorder after a single session of EMDR. Our patient had been followed-up for schizophrenia according to DSM5 criteria, since 4 years. During our subject's fourth hospitalization for major delirious decompensation, a single EMDR session, according to the standard protocol, resulted in a complete and total remission of the delirious disorder and the disorganization/dissociative syndrome in 8 weeks. This allowed us to interrupt the patient's antipsychotic treatment without relapse at 18 months. This case study allows us to highlight, as many authors have previously done, the necessity of researching the traumatic history of patients diagnosed with schizophrenia in order to provide therapies focused on traumatic dissociation. It also questions the relevance of our diagnostic criteria for schizophrenia and other dissociative disorders.. Presentamos un estudio de caso sobre la remisión de una esquizofrenia químicamente resistente tras una sola sesión de EMDR. Nuestro paciente había sido seguido por esquizofrenia según los criterios del DSM 5, desde hace 4 años. Durante la cuarta hospitalización de nuestro sujeto, por descompensación delirante mayor, una única sesión de EMDR según el protocolo estándar, dio lugar a una remisión completa y total del trastorno delirante y del síndrome de desorganización/disociativo en 8 semanas. Esto nos permitió interrumpir el tratamiento antipsicótico de la paciente sin recaídas a los 18 meses. Este estudio de caso nos permite destacar, como muchos autores han hecho anteriormente, la necesidad de investigar la historia traumática de los pacientes diagnosticados de esquizofrenia para ofrecer terapias centradas en la disociación traumática. También cuestiona la pertinencia de nuestros criterios diagnósticos para la esquizofrenia y otros trastornos disociativos.. 我们呈现了一个在一次 EMDR 治疗后耐药性精神分裂障碍得到缓解的案例研究。我们的患者根据 DSM5 标准接受了精神分裂随访 4 年。在我们的受试者第四次因严重谵妄失代偿住院期间, 根据标准方案进行了一次 EMDR 治疗, 使谵妄障碍和解体/解离综合征在 8 周内彻底缓解。这使我们能够在 18 个月时中断患者的抗精神病治疗而没有复发。正如许多作者之前所做的那样, 本案例研究使我们能够强调研究精神分裂症患者创伤史以提供聚焦创伤性解离治疗方法的必要性。它还质疑了我们对精神分裂症和其他分离性障碍诊断标准的相关性。.

Topics: Adult; Antipsychotic Agents; Clozapine; Dissociative Disorders; Eye Movement Desensitization Reprocessing; Humans; Male; Remission, Spontaneous; Schizophrenia, Treatment-Resistant

Recent case studies suggest that impaired granulopoiesis, well-known to occur during clozapine treatment, may also be observed when olanzapine is administered. The underlying mechanisms are unknown, but haematopoietic cytokines such as granulocyte colony-stimulating factor (G-CSF) are likely to be involved.. We measured the plasma levels of G-CSF and of other cytokines longitudinally in a female patient who developed granulocytopenia twice, first during clozapine treatment and again when olanzapine was administered.. G-CSF levels, but not those of other cytokines, closely paralleled granulocyte counts, yielding a significant positive correlation. G-CSF was not detectable in plasma when granulocytopenia occurred. Granulocytopenia resolved spontaneously despite continuing treatment with olanzapine.. The present case suggests that clozapine and olanzapine both are able to induce transient granulocytopenia through a similar or common mechanism that does not involve a compensatory increase in G-CSF levels.

Topics: Adult; Agranulocytosis; Antipsychotic Agents; Benzodiazepines; Clozapine; Cytokines; Female; Granulocyte Colony-Stimulating Factor; Granulocytes; Hospitalization; Humans; Leukocyte Count; Olanzapine; Pirenzepine; Remission, Spontaneous; Schizophrenia

The results of treating 251 therapeutically resistant patients with paranoid schizophrenia by moditen-depo, its combination with other psychotic drugs or leponex was compared. The results obtained indicate that a comprehensive treatment (moditen-depo with other psychotropic drugs) and by leponex may be successfully applied to some of the paranoid schizophrenics resistant to moditen-depo and other neuroleptic drugs or their combinations. Comprehensive treatment appeared to be more effective in systematized delusions, the syndrome of psychic automatisms and in a crude emotional-volitional defect. Treatment by leponex was more efficacious in emotionally saturated nonsystematized delusions, pronounced disordered behaviour and mild manifestation of deterioration.

Topics: Adolescent; Adult; Antidepressive Agents; Antipsychotic Agents; Clozapine; Delayed-Action Preparations; Depression; Dibenzazepines; Drug Therapy, Combination; Female; Fluphenazine; Humans; Male; Middle Aged; Psychotropic Drugs; Remission, Spontaneous; Schizophrenia, Paranoid

The treatment of acute schizophrenic disorders with large doses of droperidol was compared to clozapine and clopenthixol in a special study. Apart from the clinical protocol, psychometric test for the assessment of social behaviour and thought disorders were used. The advantages of the treatment with droperidol, especially in highly disturbed acute schizophrenic patients, are shown and discussed by means of the results of psychological tests and clinical experience.

Topics: Acute Disease; Biperiden; Blood Pressure; Clopenthixol; Clozapine; Droperidol; Drug Administration Schedule; Drug Evaluation; Humans; Male; Psychological Tests; Remission, Spontaneous; Salivation; Schizophrenia; Schizophrenic Psychology