clozapine has been researched along with Pruritus* in 3 studies
3 other study(ies) available for clozapine and Pruritus
| Article | Year |
|---|---|
Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice.
Several lines of evidence have clarified that the key transmission pathways of itching sensation travel from the periphery to the central nervous system (CNS). Despite the functional significance of gastrin-releasing peptide (GRP) and its cognate receptor in the itch processing mechanism in the spinal dorsal horn (SDH), the roles of GRP-expressing (GRP Topics: Animals; Behavior, Animal; Clozapine; Cyclopropanes; Dermatitis, Contact; Female; Gastrin-Releasing Peptide; Haptens; Male; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Pruritus | 2021 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
There is a major clinical need for new therapies for the treatment of chronic itch. Many of the molecular components involved in itch neurotransmission are known, including the neuropeptide NPPB, a transmitter required for normal itch responses to multiple pruritogens in mice. Here, we investigated the potential for a novel strategy for the treatment of itch that involves the inhibition of the NPPB receptor NPR1 (natriuretic peptide receptor 1). Because there are no available effective human NPR1 (hNPR1) antagonists, we performed a high-throughput cell-based screen and identified 15 small-molecule hNPR1 inhibitors. Using in vitro assays, we demonstrated that these compounds specifically inhibit hNPR1 and murine NPR1 (mNPR1). In vivo, NPR1 antagonism attenuated behavioral responses to both acute itch- and chronic itch-challenged mice. Together, our results suggest that inhibiting NPR1 might be an effective strategy for treating acute and chronic itch. Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Specific activation of inhibitory interneurons in the spinal dorsal horn suppresses repetitive scratching in mouse models of chronic itch.
Topics: Animals; Behavior, Animal; Clozapine; Cyclopropanes; Disease Models, Animal; GABAergic Neurons; Gene Knock-In Techniques; Genetic Engineering; Humans; Injections, Spinal; Interneurons; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pruritus; Receptor, Muscarinic M3; Spinal Cord Dorsal Horn; Treatment Outcome | 2017 |