clozapine has been researched along with Frontotemporal-Dementia* in 2 studies
2 other study(ies) available for clozapine and Frontotemporal-Dementia
| Article | Year |
|---|---|
Plasma neurofilament light chain protein is not increased in treatment-resistant schizophrenia and first-degree relatives.
Schizophrenia, a complex psychiatric disorder, is often associated with cognitive, neurological and neuroimaging abnormalities. The processes underlying these abnormalities, and whether a subset of people with schizophrenia have a neuroprogressive or neurodegenerative component to schizophrenia, remain largely unknown. Examining fluid biomarkers of diverse types of neuronal damage could increase our understanding of these processes, as well as potentially provide clinically useful biomarkers, for example with assisting with differentiation from progressive neurodegenerative disorders such as Alzheimer and frontotemporal dementias.. We found no differences in NfL levels between treatment-resistant schizophrenia (mean NfL, M = 6.3 pg/mL, 95% confidence interval: [5.5, 7.2]), first-degree relatives (siblings, M = 6.7 pg/mL, 95% confidence interval: [5.2, 8.2]; parents, M after adjusting for age = 6.7 pg/mL, 95% confidence interval: [4.7, 8.8]), controls (M = 5.8 pg/mL, 95% confidence interval: [5.3, 6.3]) and not treated with clozapine (M = 4.9 pg/mL, 95% confidence interval: [4.0, 5.8]). Exploratory, hypothesis-generating analyses found weak correlations in treatment-resistant schizophrenia, between NfL and clozapine levels (Spearman's. Treatment-resistant schizophrenia does not appear to be associated with neuronal, particularly axonal degeneration. Further studies are warranted to investigate the utility of NfL to differentiate treatment-resistant schizophrenia from neurodegenerative disorders such as behavioural variant frontotemporal dementia, and to explore NfL in other stages of schizophrenia such as the prodome and first episode. Topics: Alzheimer Disease; Biomarkers; Child; Clozapine; Frontotemporal Dementia; Humans; Intermediate Filaments; Neurodegenerative Diseases; Neurofilament Proteins; Schizophrenia; Schizophrenia, Treatment-Resistant | 2022 |
A Case of Frontotemporal Dementia Presenting With Treatment-Refractory Psychosis and Extreme Violence: Response to Combination of Clozapine, Medroxyprogesterone, and Sertraline.
Topics: Adult; Clozapine; Contraceptives, Oral, Synthetic; Drug Therapy, Combination; Frontotemporal Dementia; Humans; Male; Medroxyprogesterone; Psychotic Disorders; Serotonin Agents; Sertraline; Violence | 2015 |