clozapine and Fatigue-Syndrome--Chronic

clozapine has been researched along with Fatigue-Syndrome--Chronic* in 1 studies

Reviews

1 review(s) available for clozapine and Fatigue-Syndrome--Chronic

Article	Year
Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions. Annals of the New York Academy of Sciences, 2001, Volume: 933 In humans, activation of the primary host defense system leads to increased or decreased NREM sleep quality, depending on the degree of early immune activation. Modest elevations of certain inflammatory cytokines are found during experimental sleep loss in humans and, in addition, relatively small elevations of cytokines are seen following commencement of pharmacological treatments with clozapine, a CNS active antipsychotic agent, known to have immunomodulatory properties. Cytokines such as TNF-alpha, its soluble receptors, and IL-6, present in the periphery and the CNS, comprise a link between peripheral immune stimulation and CNS-mediated behaviors and experiences such as sleep, sleepiness, and fatigue. The debilitating fatigue experienced in chronic fatigue syndrome and related diseases may also be related to altered cytokine profiles. Topics: Animals; Antipsychotic Agents; Clozapine; Cytokines; Endotoxins; Fatigue; Fatigue Syndrome, Chronic; Fibromyalgia; Humans; Inflammation Mediators; Multiple Chemical Sensitivity; Neuroimmunomodulation; Receptors, Cytokine; Sleep; Sleep Stages; Sleep Wake Disorders	2001

Article

Year

Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.

Annals of the New York Academy of Sciences, 2001, Volume: 933

In humans, activation of the primary host defense system leads to increased or decreased NREM sleep quality, depending on the degree of early immune activation. Modest elevations of certain inflammatory cytokines are found during experimental sleep loss in humans and, in addition, relatively small elevations of cytokines are seen following commencement of pharmacological treatments with clozapine, a CNS active antipsychotic agent, known to have immunomodulatory properties. Cytokines such as TNF-alpha, its soluble receptors, and IL-6, present in the periphery and the CNS, comprise a link between peripheral immune stimulation and CNS-mediated behaviors and experiences such as sleep, sleepiness, and fatigue. The debilitating fatigue experienced in chronic fatigue syndrome and related diseases may also be related to altered cytokine profiles.

Topics: Animals; Antipsychotic Agents; Clozapine; Cytokines; Endotoxins; Fatigue; Fatigue Syndrome, Chronic; Fibromyalgia; Humans; Inflammation Mediators; Multiple Chemical Sensitivity; Neuroimmunomodulation; Receptors, Cytokine; Sleep; Sleep Stages; Sleep Wake Disorders

2001