clozapine and Epilepsy--Complex-Partial

Topics: Adult; Antipsychotic Agents; Clozapine; Drug Administration Schedule; Epilepsy; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; Humans; Male; Psychotic Disorders

Diagnostic considerations and treatment strategies in adolescents with partial complex epilepsy and emerging psychosis are discussed. We will argue for considering clozapine early in treatment if other antipsychotics have failed based on two cases; these patients both developed epilepsy in early childhood and schizophrenia in mid adolescence. Their partial complex epilepsy were unsuccessfully treated with different antiepileptic drugs. Clozapine was tried with a distinct improvement in psychotic symptoms and functional level. In both cases there was an early unexpected improvement in seizure control on clozapine. It appears that a reduction of psychotic activity improved seizure control. Later on, there appeared to be a trade off between clozapines effect on psychotic symptoms and recurrence of seizure activity.. A schizophrenic development must be taken into consideration if psychiatric symptoms emerge in adolescents with a partial complex epileptic disorder. Clozapine treatment can be considered if other antipsychotic drugs are ineffective or cause motor side effects.

Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Child; Clozapine; Diagnosis, Differential; Epilepsy, Complex Partial; Female; Humans; Male; Psychotic Disorders