clozapine and Colitis

clozapine has been researched along with Colitis* in 9 studies

Reviews

2 review(s) available for clozapine and Colitis

ArticleYear
Clinical determinants of fever in clozapine users and implications for treatment management: A narrative review.
    Schizophrenia research, 2019, Volume: 211

    To identify the clinical determinants of fever in clozapine users and their impact on management of clozapine treatment.. Articles published in English or French identified with a MEDLINE, Web of Sciences, Cochrane Library and PsycINFO search, from inception through February 2019, using the term "clozapine" in combination with "fever" OR "hyperthermia" OR "body temperature" OR "pyrexia" OR "febrile" OR "heat" OR "thermoregulation". Information extracted for each medical condition were frequency, time to onset after initiation of clozapine treatment, characteristics of fever, associated symptoms, laboratory tests used for diagnosis, course, lethality, discontinuation of clozapine. Data were synthesized narratively.. Our search yielded 394 unique hits published from 1993 to 2018. We included 73 articles in the review: two meta-analyses, 14 reviews, six epidemiological studies, 11 clinical studies and 40 case reports. During clozapine initiation, fever is most frequently benign and transient but should be closely monitored as it may be the first stage of potentially life-threatening adverse drug reactions (ADR) (agranulocytosis, neuroleptic malignant syndrome myocarditis, hepatitis, pancreatitis, nephritis, colitis, etc.). Other ADR associated with fever are independent of duration of exposure to clozapine (heat stroke, pneumonia, pulmonary embolism, necrotizing colitis). If fever is due to intercurrent infection, therapeutic drug monitoring is recommended to adjust clozapine daily dosage.. Benign causes of fever are much more frequent than life-threatening ADR during clozapine treatment. Discontinuation should not be considered as automatic in the event of fever, especially during the early phase of clozapine initiation.

    Topics: Agranulocytosis; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Clozapine; Colitis; Dose-Response Relationship, Drug; Drug Monitoring; Fever; Hepatitis; Humans; Infections; Lupus Erythematosus, Systemic; Myocarditis; Nephritis; Neuroleptic Malignant Syndrome; Pancreatitis; Pneumonia; Pulmonary Embolism; Schizophrenia; Serositis

2019
Clozapine-associated colitis: case report and review of the literature.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:4

    Topics: Adult; Antipsychotic Agents; Clozapine; Colitis; Female; Humans

2012

Other Studies

7 other study(ies) available for clozapine and Colitis

ArticleYear
Clozapine-induced stercoral colitis: a surgical perspective.
    BMJ case reports, 2019, Aug-30, Volume: 12, Issue:8

    We describe a case of a 46-year-old man with schizophrenia treated with clozapine who presented as an emergency with abdominal pain on the background of a 1 month history of constipation. The initial presenting symptoms were vague and a diagnosis was difficult to establish. Initial CT of the abdomen and pelvis demonstrated only minor abnormalities. He continued to deteriorate until a further CT scan revealed worsening stercoral colitis. He subsequently underwent an emergency total colectomy and ileostomy formation and had a complicated prolonged postoperative recovery. This case highlights the risks that clozapine can have on slowing bowel transit and the dangerous consequences that can occur if not identified early.

    Topics: Abdominal Pain; Antipsychotic Agents; Clozapine; Colitis; Humans; Male; Middle Aged; Schizophrenia

2019
Clozapine-Associated Cytomegalovirus Colitis and Related Critical Illness in a Patient With Neither Neutropenia Nor Agranulocytosis.
    The Annals of pharmacotherapy, 2019, Volume: 53, Issue:2

    Topics: Agranulocytosis; Antipsychotic Agents; Clozapine; Colitis; Critical Illness; Cytomegalovirus; Cytomegalovirus Infections; Female; Humans; Middle Aged; Neutropenia; Schizophrenia

2019
[Acute colitis and delirium syndrome under clozapine therapy].
    Der Nervenarzt, 2013, Volume: 84, Issue:5

    Topics: Adult; Antipsychotic Agents; Clozapine; Colitis; Delirium; Female; Humans; Syndrome; Treatment Outcome

2013
[Eosinophilic colitis caused by clozapine].
    Nederlands tijdschrift voor geneeskunde, 2011, Volume: 155, Issue:36

    Clozapine is an antipsychotic agent used when patients experience excessive extrapyramidal side effects from other antipsychotic agents or for therapy resistant schizophrenia. However, clozapine is also known for its serious adverse effects e.g. granulocytopenia and agranulocytosis.. A 40-year-old male with known schizophrenia, presented with severe diarrhea and eosinophilia in the peripheral blood examination result, arising 2 weeks after starting clozapine. Histopathological examination demonstrated an eosinophilic colitis. After the patient discontinued clozapine, the symptoms disappeared completely.. Eosinophilic colitis is a rare adverse effect of clozapine. It is only possible to diagnose this using endoscopy and biopsy, so that the complaint is often not recognised. The exact pathophysiology underlying this eosinophilic colitis is not known.

    Topics: Adult; Antipsychotic Agents; Clozapine; Colitis; Eosinophilia; Humans; Male; Schizophrenia

2011
Clozapine-induced eosinophilic colitis.
    The American journal of psychiatry, 2005, Volume: 162, Issue:7

    Topics: Antipsychotic Agents; Blood Sedimentation; Clozapine; Colitis; Diarrhea; Eosinophilia; Fever; Humans; Male; Middle Aged; Schizophrenia

2005
Clozapine associated neutropenia and cytomegalovirus colitis.
    Pharmacopsychiatry, 1998, Volume: 31, Issue:6

    Both diarrhea and colitis associated with clozapine have been reported. We present a case of clozapine-associated neutropenia complicated by cytomegalovirus colitis. The definitive diagnosis was suggested on biopsy which showed eosinophilic intranuclear inclusions suggestive of cytomegalovirus infection, and confirmed on immunohistochemistry. Neutropenia or agranulocytosis in association with clozapine treatment may be complicated by colitis. In such cases, investigations for cytomegalovirus may be indicated.

    Topics: Adult; Antipsychotic Agents; Clozapine; Colitis; Cytomegalovirus Infections; Female; Humans; Neutropenia

1998
Clozapine-caused eosinophilic colitis.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 1995, Volume: 7, Issue:2

    Four patients with diarrhea and eosinophilia associated with clozapine therapy are presented. In two cases clozapine therapy was interrupted but then restarted; all patients eventually tolerated clozapine well. A syndrome of clozapine-induced eosinophilic colitis is suggested.

    Topics: Adult; Antipsychotic Agents; Clozapine; Colitis; Eosinophilia; Female; Humans; Male; Middle Aged; Schizophrenia

1995