clozapine and Atrioventricular-Block

clozapine has been researched along with Atrioventricular-Block* in 2 studies

Other Studies

2 other study(ies) available for clozapine and Atrioventricular-Block

Article	Year
Complete atrioventricular block associated with clozapine intoxication: case report. The Turkish journal of pediatrics, 2019, Volume: 61, Issue:4 Türe M, Bilici M, Akın A, Demir F, Balık H, Darakçı SM. Complete atrioventricular block associated with clozapine intoxication: case report. Turk J Pediatr 2019; 61: 618-621. Clozapine is one of the atypical anti-psychotic drugs used in the treatment of resistant schizophrenia. Although cardiac side-effects are rare, it has been reported that there may be development of myocarditis, dilated cardiomyopathy, postural orthostatic hypotension and prolonged QT duration. Complete atrioventricular (AV) block is characterized by the inability to transmit all of the atrial signal to the ventricles. Causes may be congenital, idiopathic or acquired which are associated with surgery, infection, or muscle disease. AV block is extremely serious and permanent pacemaker insertion is usually necessary for all patients. Complete AV block may develop due to clozapine intoxication through increase in vagal tonus, sinoatrial node (SN) and the inhibition of atrioventricular node signalling. The case presented here is of a 15-year old female patient who developed AV total cardiac block associated with the taking of clozapine in a suicide attempt. Topics: Adolescent; Antipsychotic Agents; Atrioventricular Block; Atrioventricular Node; Clozapine; Electrocardiography; Female; Humans; Pacemaker, Artificial; Suicide, Attempted	2019
Complete AV-block secondary to lithium-clozapine therapy and relapsing multiple sclerosis in a bipolar patient. BMJ case reports, 2011, Dec-01, Volume: 2011 A complete atrioventricular block (CAVB) can be a lethal complication when it is not treated directly with isoprenaline and pacemaker therapy. The overall incidence of CAVB varies between 4 to 8 per cent with a mortality OR of 3.2 within 30 days if untreated. Main causes of CAVB are inferior myocardial infarction, congenital AV node malformation, mitral valve insufficiency and valve surgery, metabolic disorders and intoxications. The authors describe a case with a CAVB due to lithium-clozapine therapy and relapsing multiple sclerosis. Topics: Antipsychotic Agents; Atrioventricular Block; Bipolar Disorder; Cardiotonic Agents; Clozapine; Female; Humans; Isoproterenol; Lithium; Middle Aged; Multiple Sclerosis; Pacemaker, Artificial; Recurrence	2011

Article

Year

Complete atrioventricular block associated with clozapine intoxication: case report.

The Turkish journal of pediatrics, 2019, Volume: 61, Issue:4

Türe M, Bilici M, Akın A, Demir F, Balık H, Darakçı SM. Complete atrioventricular block associated with clozapine intoxication: case report. Turk J Pediatr 2019; 61: 618-621. Clozapine is one of the atypical anti-psychotic drugs used in the treatment of resistant schizophrenia. Although cardiac side-effects are rare, it has been reported that there may be development of myocarditis, dilated cardiomyopathy, postural orthostatic hypotension and prolonged QT duration. Complete atrioventricular (AV) block is characterized by the inability to transmit all of the atrial signal to the ventricles. Causes may be congenital, idiopathic or acquired which are associated with surgery, infection, or muscle disease. AV block is extremely serious and permanent pacemaker insertion is usually necessary for all patients. Complete AV block may develop due to clozapine intoxication through increase in vagal tonus, sinoatrial node (SN) and the inhibition of atrioventricular node signalling. The case presented here is of a 15-year old female patient who developed AV total cardiac block associated with the taking of clozapine in a suicide attempt.

Topics: Adolescent; Antipsychotic Agents; Atrioventricular Block; Atrioventricular Node; Clozapine; Electrocardiography; Female; Humans; Pacemaker, Artificial; Suicide, Attempted

2019

Complete AV-block secondary to lithium-clozapine therapy and relapsing multiple sclerosis in a bipolar patient.

BMJ case reports, 2011, Dec-01, Volume: 2011

A complete atrioventricular block (CAVB) can be a lethal complication when it is not treated directly with isoprenaline and pacemaker therapy. The overall incidence of CAVB varies between 4 to 8 per cent with a mortality OR of 3.2 within 30 days if untreated. Main causes of CAVB are inferior myocardial infarction, congenital AV node malformation, mitral valve insufficiency and valve surgery, metabolic disorders and intoxications. The authors describe a case with a CAVB due to lithium-clozapine therapy and relapsing multiple sclerosis.

Topics: Antipsychotic Agents; Atrioventricular Block; Bipolar Disorder; Cardiotonic Agents; Clozapine; Female; Humans; Isoproterenol; Lithium; Middle Aged; Multiple Sclerosis; Pacemaker, Artificial; Recurrence

2011