clove and Tungiasis

clove has been researched along with Tungiasis* in 3 studies

Trials

1 trial(s) available for clove and Tungiasis

ArticleYear
Prevention of tungiasis and tungiasis-associated morbidity using the plant-based repellent Zanzarin: a randomized, controlled field study in rural Madagascar.
    PLoS neglected tropical diseases, 2013, Volume: 7, Issue:9

    Tungiasis, a parasitic skin disease caused by the female sand flea Tunga penetrans, is a prevalent condition in impoverished communities in the tropics. In this setting, the ectoparasitosis is associated with important morbidity. It causes disfigurement and mutilation of the feet. Feasible and effective treatment is not available. So far prevention is the only means to control tungiasis-associated morbidity.. In two villages in Central Madagascar, we assessed the efficacy of the availability of closed shoes and the twice-daily application of a plant-based repellent active against sand fleas (Zanzarin) in comparison to a control group without intervention. The study population was randomized into three groups: shoe group, repellent group and control group and monitored for ten weeks. The intensity of infestation, the attack rate and the severity of tungiasis-associated morbidity were assessed every two weeks.. In the repellent group, the median attack rate became zero already after two weeks. The intensity of the infestation decreased constantly during the observation period and tungiasis-associated morbidity was lowered to an insignificant level. In the shoe group, only a marginal decrease in the intensity of infestation and in the attack rate was observed. At week 10, the intensity of infestation, the attack rate and the severity score for acute tungiasis remained significantly higher in the shoe group than in the repellent group. Per protocol analysis showed that the protective effect of shoes was closely related to the regularity with which shoes were worn.. Although shoes were requested by the villagers and wearing shoes was encouraged by the investigators at the beginning of the study, the availability of shoes only marginally influenced the attack rate of female sand fleas. The twice-daily application of a plant-based repellent active against sand fleas reduced the attack to zero and lowered tungiasis-associated morbidity to an insignificant level.

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Child; Child, Preschool; Female; Humans; Insect Repellents; Madagascar; Male; Middle Aged; Pantothenic Acid; Plant Extracts; Plant Oils; Prevalence; Rural Population; Severity of Illness Index; Treatment Outcome; Tunga; Tungiasis; Young Adult

2013

Other Studies

2 other study(ies) available for clove and Tungiasis

ArticleYear
Image Gallery: Tungiasis in four steps.
    The British journal of dermatology, 2019, Volume: 180, Issue:4

    Topics: Animals; Dermoscopy; Female; Foot; Humans; Madagascar; Middle Aged; Skin; Travel-Related Illness; Treatment Outcome; Tunga; Tungiasis

2019
Regression of severe tungiasis-associated morbidity after prevention of re-infestation: a case series from rural Madagascar.
    The American journal of tropical medicine and hygiene, 2013, Volume: 89, Issue:5

    Tungiasis (sand flea disease) is a neglected tropical disease. Heavy infestation results in mutilation of the feet and difficulty in walking. We identified eight individuals with extremely severe tungiasis in rural Madagascar. To prevent reinfestation, four individuals received solid shoes and four received a daily application of an herbal repellent effective against Tunga penetrans. Over a period of 10 weeks the feet were examined and the severity of tungiasis-associated morbidity was measured. Within this period, the severity score for acute tungiasis decreased 41% in the shoe group and 89% in the repellent group. The four major inflammation-related symptoms disappeared in the four patients of the repellent group, but only in two patients of the shoe group. Those observations indicate that cases with extremely severe tungiasis, associated morbidity almost totally disappears within 10 weeks if the feet are protected by a repellent. Wearing shoes reduced acute morbidity only marginally.

    Topics: Adolescent; Adult; Aged; Animals; Child; Female; Foot; Humans; Insect Repellents; Madagascar; Male; Middle Aged; Poverty; Rural Population; Secondary Prevention; Shoes; Tunga; Tungiasis

2013
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