clove and Otitis-Externa

clove has been researched along with Otitis-Externa* in 1 studies

Other Studies

1 other study(ies) available for clove and Otitis-Externa

Article	Year
Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae. Bioorganic & medicinal chemistry, 2006, Aug-15, Volume: 14, Issue:16 Leaf extracts of Ugni molinae Turcz. are used in the Chilean cosmetic industry on the assumption that they have decongestant, regenerative, and anti-aging properties. A bioassay-guided fractionation of this plant material showed that some extracts have potent anti-inflammatory activities. Further fractionation led to the isolation and identification of betulinic acid, a mixture of ursolic and oleanolic acids, and the 2alpha-hydroxy derivatives alphitolic, asiatic, and corosolic acids. The latter three were evaluated in vivo in the mouse ear assay for their topical anti-inflammatory activity, inducing inflammation with either arachidonic acid (AA) or 12-O-tetradecanoylphorbol-13 acetate (TPA). Only corosolic acid was active in the AA assay, with similar potency to nimesulide, but all three triterpene acids inhibited TPA-induced inflammation with potencies comparable to that of indomethacin. Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Betulinic Acid; Dose-Response Relationship, Drug; Indomethacin; Male; Mice; Myrtaceae; Otitis Externa; Pentacyclic Triterpenes; Plant Leaves; Polycyclic Compounds; Sulfonamides; Tetradecanoylphorbol Acetate; Triterpenes	2006

Article

Year

Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae.

Bioorganic & medicinal chemistry, 2006, Aug-15, Volume: 14, Issue:16

Leaf extracts of Ugni molinae Turcz. are used in the Chilean cosmetic industry on the assumption that they have decongestant, regenerative, and anti-aging properties. A bioassay-guided fractionation of this plant material showed that some extracts have potent anti-inflammatory activities. Further fractionation led to the isolation and identification of betulinic acid, a mixture of ursolic and oleanolic acids, and the 2alpha-hydroxy derivatives alphitolic, asiatic, and corosolic acids. The latter three were evaluated in vivo in the mouse ear assay for their topical anti-inflammatory activity, inducing inflammation with either arachidonic acid (AA) or 12-O-tetradecanoylphorbol-13 acetate (TPA). Only corosolic acid was active in the AA assay, with similar potency to nimesulide, but all three triterpene acids inhibited TPA-induced inflammation with potencies comparable to that of indomethacin.

Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Betulinic Acid; Dose-Response Relationship, Drug; Indomethacin; Male; Mice; Myrtaceae; Otitis Externa; Pentacyclic Triterpenes; Plant Leaves; Polycyclic Compounds; Sulfonamides; Tetradecanoylphorbol Acetate; Triterpenes

2006