clove and Nausea

The therapeutic effects and side effects of mefloquine in falciparum malaria were investigated in an open prospective trial involving 20 patients. None of them had a history of neurologic or psychiatric disorders. Mefloquine was given in a total dose of 1500 mg base. The cure rate was 100%, fever and parasitemia subsided within 3 days. Side effects were vomitus and nausea in 25% of the patients. No neurological or psychiatric disorders were observed. Mefloquine was shown to be a safe therapeutic agent in the dosage used. However, regular follow-up examinations should be done in short intervals because of the possibility of late neuropsychiatric side effects; the patients and their relatives should be informed about this fact.

Topics: Adolescent; Adult; Africa, Western; Animals; Female; Germany; Humans; Madagascar; Malaria; Male; Mefloquine; Mental Disorders; Nausea; Nervous System Diseases; Plasmodium falciparum; Prospective Studies; Travel; Uganda; Vomiting