clove and Anemia--Sickle-Cell

The Network for the Study of Sickle Cell Disease in Central Africa or REDAC, is a network of African, European and American researchers whose aim is to combat sickle cell disease. Its congresses take place every year in the partner countries with international symposia alternating with workshops. REDAC enables host countries to obtain from local authorities a real involvement in the fight through resolutions in line with national strategies of fight. The Seventh International Symposium of REDAC was held in 2018 in Antananarivo, Madagascar under the auspices of the Malagasy Minister of Health and the Malagasy Senate Authorities. The theme chosen was that of strategies to combat sickle cell disease recommended by the WHO. The presentations focused on neonatal screening, early diagnosis, management of sickle cell disease and new therapies (marrow transplant, gene therapy and treatment with hydroxyurea).

Topics: Anemia, Sickle Cell; Black People; Humans; Infant, Newborn; Madagascar; Neonatal Screening; World Health Organization

sickle cell trait is the heterozygous form of sickle-cell disease. Patients with sickle cell trait can synthesize normal hemoglobin A and hemoglobin S. This condition has no recognizable clinical signs; then subjects with sickle cell trait, ignoring their genetic status, can be found among blood donors. This can have severe impact on donors´ health status and on that of recipients, especially if these have sickle-cell trait. The purpose of our study is to determine the prevalence of sickle cell trait in blood donors.. we conducted a 4-month descriptive prospective study (January-May 2017) at the Haute Matsiatra Regional Blood Transfusion Center (RBTC). All donors were screened by Emmel test and positive cases were confirmed by hemoglobin electrophoresis.. the study involved 427 donors, of whom 332 were men and 95 women (sex ratio 3.4). The average age of blood donors was 32.72, ranging from 18 to 64 years. Emmel test was positive in 5 donors (1.17%). These patients had the AS genotype confirmed by hemoglobin electrophoresis.. the results of this study reveal the presence of sickle cell trait among blood donors at the CRTS. Most of them ignore their sickle cell status before blood donation. Quality and safety of blood and blood products are mandatory, hence the importance of screening among blood donors is a current relevant issue.

Topics: Adolescent; Adult; Anemia, Sickle Cell; Blood Banks; Blood Donors; Blood Transfusion; Female; Humans; Madagascar; Male; Middle Aged; Prevalence; Regional Medical Programs; Sickle Cell Trait; Young Adult

The main public health issue in Madagascar at the beginning of the 21st century still involves transmissible infectious diseases including re-emerging diseases such as bubonic plague and emerging diseases such as HIV/AIDS, dengue fever and Chikungunya virus infection. Health and hygiene especially access to clean water is still poor especially in rural areas. No improvement in the public health situation with regard to malaria, schistomosomiais or cysticercosis as well as non-infectious diseases such as protein-energy malnutrition is expected within the next decade.

Topics: Anemia, Sickle Cell; Animals; Bites and Stings; Communicable Diseases; Delivery of Health Care; Demography; Diabetes Mellitus; Geography; Humans; Madagascar; Malnutrition; Neoplasms; Public Health; Sanitation

An evaluation of health problems is done in a village in Eastern Madagascar, where takes place a development programme. 217 inhabitants go through physical examination and lab tests are performed (Blood smear - Thick drop. Emmel test. Stools examination for parasites and enteroviruses). The epidemiologic investigation reveals the prevalences of Malaria (39,4 p. 100) intestinal schistosomiasis (59,9 p. 100) Ascaridiasis (61,3 p. 100) Hookworm (29,9 p. 100) Trichuriasis (19,8 p. 100) and sickle cells anemia (4,80 p. 100). The signs and symptoms are analysed, particularly spleen enlargement which is shown to be due to schistosomiasis. The local transmition pattern of schistosomiasis is investigated and, according to the malacological findings, is thought to be intermittent. The determination of the local hookworm is started. It should be Necator americanus. The sanitary programme to be set is considered regarding the local contexte.

Topics: Age Factors; Anemia, Sickle Cell; Animals; Ascaridiasis; Disease Vectors; Feces; Health Surveys; Hookworm Infections; Humans; Madagascar; Malaria; Mollusca; Sanitation; Schistosomiasis; Splenomegaly; Trichuriasis

Topics: Anemia; Anemia, Sickle Cell; Anthropology; Black People; Humans; Madagascar

Topics: Anemia; Anemia, Sickle Cell; Black People; Erythrocytes, Abnormal; Humans; Madagascar