clotrimazole has been researched along with Hypoxia in 7 studies
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have examined the effect of hydroxyurea (HU), clotrimazole (CLT), magnesium oxide (Mg), and combined CLT+Mg therapies on the erythrocyte characteristics and their response to chronic hypoxia in a transgenic sickle mouse (SAD) model." | 7.70 | Formation of dense erythrocytes in SAD mice exposed to chronic hypoxia: evaluation of different therapeutic regimens and of a combination of oral clotrimazole and magnesium therapies. ( Beuzard, Y; Brugnara, C; De Franceschi, L; Jouault, H; Rouyer-Fessard, P, 1999) |
| "We have examined the effect of hydroxyurea (HU), clotrimazole (CLT), magnesium oxide (Mg), and combined CLT+Mg therapies on the erythrocyte characteristics and their response to chronic hypoxia in a transgenic sickle mouse (SAD) model." | 3.70 | Formation of dense erythrocytes in SAD mice exposed to chronic hypoxia: evaluation of different therapeutic regimens and of a combination of oral clotrimazole and magnesium therapies. ( Beuzard, Y; Brugnara, C; De Franceschi, L; Jouault, H; Rouyer-Fessard, P, 1999) |
| "A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation." | 1.32 | ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. ( Beuzard, Y; Brugnara, C; Corrocher, R; De Franceschi, L; McNaughton-Smith, GA; Stocker, JW, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loganathan, A | 1 |
| Linley, JE | 1 |
| Rajput, I | 1 |
| Hunter, M | 1 |
| Lodge, JP | 1 |
| Sandle, GI | 1 |
| Miller, BA | 1 |
| Wang, J | 1 |
| Hirschler-Laszkiewicz, I | 1 |
| Gao, E | 1 |
| Song, J | 1 |
| Zhang, XQ | 1 |
| Koch, WJ | 1 |
| Madesh, M | 1 |
| Mallilankaraman, K | 1 |
| Gu, T | 1 |
| Chen, SJ | 1 |
| Keefer, K | 1 |
| Conrad, K | 1 |
| Feldman, AM | 1 |
| Cheung, JY | 1 |
| Stocker, JW | 1 |
| De Franceschi, L | 2 |
| McNaughton-Smith, GA | 1 |
| Corrocher, R | 1 |
| Beuzard, Y | 2 |
| Brugnara, C | 2 |
| Hatton, CJ | 2 |
| Peers, C | 2 |
| Rouyer-Fessard, P | 1 |
| Jouault, H | 1 |
| Roy, A | 1 |
| Rozanov, C | 1 |
| Mokashi, A | 1 |
| Lahiri, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase III Multicenter, 52-Week, Randomized, Double-Blind, Placebo-Controlled Study of the Clinical Efficacy and Safety of ICA-17043 With or Without HU Therapy in Patients With Sickle Cell Disease Who Have Had =>2 Acute Sickle-Related Painful Crises With[NCT00102791] | Phase 3 | 297 participants (Actual) | Interventional | 2005-02-28 | Terminated (stopped due to Because of the low probability of achieving the primary endpoint.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for clotrimazole and Hypoxia
| Article | Year |
|---|---|
Basolateral potassium (IKCa) channel inhibition prevents increased colonic permeability induced by chemical hypoxia.
Topics: Clotrimazole; Colon; Deoxyglucose; Dinitrophenols; Glycolysis; Humans; Hypoxia; Intermediate-Conduct | 2011 |
The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury.
Topics: Action Potentials; Animals; Calcium; Clotrimazole; Echocardiography; Forkhead Transcription Factors; | 2013 |
ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice.
Topics: Acetamides; Anemia, Sickle Cell; Animals; Calcium; Calcium Channel Blockers; Clotrimazole; Erythrocy | 2003 |
Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells.
Topics: Animals; Antifungal Agents; Calcium Channel Blockers; Carotid Body; Cell Separation; Cells, Cultured | 1996 |
Is cytochrome P-450 involved in hypoxic inhibition of K+ currents in rat type I carotid body cells?
Topics: Action Potentials; Animals; Carotid Body; Cell Hypoxia; Cells, Cultured; Clotrimazole; Cytochrome P- | 1996 |
Formation of dense erythrocytes in SAD mice exposed to chronic hypoxia: evaluation of different therapeutic regimens and of a combination of oral clotrimazole and magnesium therapies.
Topics: Administration, Oral; Anemia, Sickle Cell; Animals; Chronic Disease; Clotrimazole; Drug Therapy, Com | 1999 |
Redox-based inhibition of K+ channel/current is not related to hypoxic chemosensory responses in rat carotid body.
Topics: Animals; Carotid Body; Chemoreceptor Cells; Clotrimazole; Cytochrome P-450 Enzyme Inhibitors; Dithio | 2000 |