clotrimazole has been researched along with Disease Models, Animal in 35 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to analyse the effects of clotrimazole (CTZ) on estrogen production pathway in endometriosis progression." | 7.96 | Clotrimazole reduces endometriosis and the estrogen concentration by downregulating aromatase. ( Alessandra Perini, J; Alessandra-Perini, J; Claudino, MC; Machado, DE; Menezes de Mendonça, E; Nasciutti, LE; Sola-Penna, M; Zancan, P, 2020) |
| "The aim of present investigation was to evaluate the potential of clotrimazole as antimalarial drug." | 7.78 | Clotrimazole nanoemulsion for malaria chemotherapy. Part II: stability assessment, in vivo pharmacodynamic evaluations and toxicological studies. ( Borhade, V; Pathak, S; Patravale, V; Sharma, S, 2012) |
| "4% clotrimazole (Pyroace W) was tested in a guinea pig model of tinea pedis using a 1% newly solution formulated preparation of miconazole (Dermalin-L) as a reference drug." | 7.70 | [Therapeutic efficacy of a topical antifungal solution preparation formulated with pyrrolnitrin and clotrimazole in combination (Pyroace W) in guinea pig model of tinea pedis]. ( Uchida, K; Ymaguchi, H, 1999) |
| "Clotrimazole (CTZ) is a potent antimycotic drug that also has a free radical scavenger activity." | 5.37 | Anti-apoptotic pro-survival effect of clotrimazole in a normothermic ischemia reperfusion injury animal model. ( de Sousa, G; Gugenheim, J; Iannelli, A; Rahmani, R; Saint-Paul, MC; Zucchini, N, 2011) |
| " These results indicate that CT-containing vaginal MTG might be further developed for safe, convenient, and effective treatment of vaginal candidasis with reduced dosing interval." | 5.31 | Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis. ( Chang, JY; Jang, DD; Kim, CK; Kim, EJ; Kong, HS; Nam, KT; Oh, YK, 2002) |
| "This study aimed to analyse the effects of clotrimazole (CTZ) on estrogen production pathway in endometriosis progression." | 3.96 | Clotrimazole reduces endometriosis and the estrogen concentration by downregulating aromatase. ( Alessandra Perini, J; Alessandra-Perini, J; Claudino, MC; Machado, DE; Menezes de Mendonça, E; Nasciutti, LE; Sola-Penna, M; Zancan, P, 2020) |
| "This study aims to investigate the influence of clotrimazol (CLTZ) on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats." | 3.79 | Effects of clotrimazol on the acute necrotizing pancreatitis in rats. ( Alhan, E; Cekic, AB; Erçin, C; Kural, BV; Türkyılmaz, S; Usta, A, 2013) |
| "The aim of present investigation was to evaluate the potential of clotrimazole as antimalarial drug." | 3.78 | Clotrimazole nanoemulsion for malaria chemotherapy. Part II: stability assessment, in vivo pharmacodynamic evaluations and toxicological studies. ( Borhade, V; Pathak, S; Patravale, V; Sharma, S, 2012) |
| "4% clotrimazole (Pyroace W) was tested in a guinea pig model of tinea pedis using a 1% newly solution formulated preparation of miconazole (Dermalin-L) as a reference drug." | 3.70 | [Therapeutic efficacy of a topical antifungal solution preparation formulated with pyrrolnitrin and clotrimazole in combination (Pyroace W) in guinea pig model of tinea pedis]. ( Uchida, K; Ymaguchi, H, 1999) |
| "Diarrhea is a major side effect of ErbB receptor tyrosine kinase inhibitors (TKIs) in cancer chemotherapy." | 1.51 | Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. ( Cil, O; Duan, T; Thiagarajah, JR; Verkman, AS, 2019) |
| "Clotrimazole is an antifungal imidazole derivative showing anti- neoplastic effect in some tumors, but its anticancer potential is still unclear in oral squamous cell carcinoma (OSCC)." | 1.40 | The in vitro and in vivo antitumor effects of clotrimazole on oral squamous cell carcinoma. ( Chen, X; Cheng, B; Hong, Y; Jia, L; Kuang, Z; Leung, WK; Wang, J; Wu, T; Xia, J, 2014) |
| "Clotrimazole (CTZ) is a potent antimycotic drug that also has a free radical scavenger activity." | 1.37 | Anti-apoptotic pro-survival effect of clotrimazole in a normothermic ischemia reperfusion injury animal model. ( de Sousa, G; Gugenheim, J; Iannelli, A; Rahmani, R; Saint-Paul, MC; Zucchini, N, 2011) |
| "Clotrimazole, which is an imidazole derivative antifungal agent, was widely used for the treatment of mycotic infections of the genitourinary tract." | 1.33 | Preparation, in vitro and in vivo evaluation of liposomal/niosomal gel delivery systems for clotrimazole. ( Chen, X; Gu, Z; Guo, Y; Ning, M; Pan, H, 2005) |
| "Treatment with clotrimazole decreased MDA levels in rats with SCI with a statistically significant difference." | 1.33 | Effects of clotrimazole on experimental spinal cord injury. ( Alver, A; Arslan, E; Baykal, S; Cakir, E; Peksoylu, B; Sayin, OC; Topbas, M; Usul, H, 2006) |
| "In vitro, treatment of NCI-H460 nonsmall cell lung cancer (NSCLC) cells with NC381 inhibited growth in a time-dependent manner." | 1.32 | NC381, a novel anticancer agent, arrests the cell cycle in G0-G1 and inhibits lung tumor cell growth in vitro and in vivo. ( Al-Qawasmeh, RA; Cao, MY; Feng, NP; Gu, XP; Jin, H; Lau, L; Lee, Y; Vassilakos, A; Viau, S; Wang, M; Wright, JA; Young, AH, 2004) |
| "Whereas alone, zeamatin was ineffective, nikkomycin Z was effective only when dosed multiple times per day, and clotrimazole efficacy was variable when administered in experimental vehicles (unlike the complex and undefined commercial preparation), zeamatin enhanced the efficacy of either of the other two drugs when they were given in combination." | 1.31 | Zeamatin, clotrimazole and nikkomycin Z in therapy of a Candida vaginitis model. ( Calderon, L; Clemons, KV; Martinez, M; Selitrennikoff, CP; Stevens, DA; Wilson, SJ, 2002) |
| " These results indicate that CT-containing vaginal MTG might be further developed for safe, convenient, and effective treatment of vaginal candidasis with reduced dosing interval." | 1.31 | Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis. ( Chang, JY; Jang, DD; Kim, CK; Kim, EJ; Kong, HS; Nam, KT; Oh, YK, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (14.29) | 18.7374 |
| 1990's | 5 (14.29) | 18.2507 |
| 2000's | 9 (25.71) | 29.6817 |
| 2010's | 13 (37.14) | 24.3611 |
| 2020's | 3 (8.57) | 2.80 |
| Authors | Studies |
|---|---|
| Pegoraro, S | 1 |
| Lang, M | 1 |
| Dreker, T | 1 |
| Kraus, J | 1 |
| Hamm, S | 1 |
| Meere, C | 1 |
| Feurle, J | 1 |
| Tasler, S | 1 |
| Prütting, S | 1 |
| Kuras, Z | 1 |
| Visan, V | 1 |
| Grissmer, S | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Machado, DE | 2 |
| Alessandra-Perini, J | 2 |
| Menezes de Mendonça, E | 1 |
| Claudino, MC | 1 |
| Nasciutti, LE | 2 |
| Sola-Penna, M | 2 |
| Zancan, P | 2 |
| Alessandra Perini, J | 1 |
| Perini, JA | 1 |
| de Mendonça, EM | 1 |
| Branco, JR | 1 |
| Rodrigues-Baptista, KC | 1 |
| Espíndola-Netto, JM | 1 |
| Dos Santos, TA | 1 |
| Coelho, WS | 1 |
| Pakharukova, MY | 1 |
| Pakharukov, YV | 1 |
| Mordvinov, VA | 1 |
| Duan, T | 1 |
| Cil, O | 1 |
| Thiagarajah, JR | 1 |
| Verkman, AS | 1 |
| Precazzini, F | 1 |
| Pancher, M | 1 |
| Gatto, P | 1 |
| Tushe, A | 1 |
| Adami, V | 1 |
| Anelli, V | 1 |
| Mione, MC | 1 |
| Cekic, AB | 1 |
| Alhan, E | 1 |
| Usta, A | 1 |
| Türkyılmaz, S | 1 |
| Kural, BV | 1 |
| Erçin, C | 1 |
| Aktas, BH | 1 |
| Qiao, Y | 1 |
| Ozdelen, E | 1 |
| Schubert, R | 1 |
| Sevinc, S | 1 |
| Harbinski, F | 1 |
| Grubissich, L | 1 |
| Singer, S | 1 |
| Halperin, JA | 1 |
| Wang, J | 1 |
| Jia, L | 1 |
| Kuang, Z | 1 |
| Wu, T | 1 |
| Hong, Y | 1 |
| Chen, X | 2 |
| Leung, WK | 1 |
| Xia, J | 1 |
| Cheng, B | 1 |
| Rasouli, MR | 1 |
| Rahimi-Movaghar, V | 1 |
| Vaccaro, AR | 1 |
| Zucchini-Pascal, N | 1 |
| de Sousa, G | 2 |
| Pizzol, J | 1 |
| Rahmani, R | 2 |
| Iannelli, A | 1 |
| Zucchini, N | 1 |
| Saint-Paul, MC | 1 |
| Gugenheim, J | 1 |
| Jia, J | 1 |
| Verma, S | 1 |
| Nakayama, S | 1 |
| Quillinan, N | 1 |
| Grafe, MR | 1 |
| Hurn, PD | 1 |
| Herson, PS | 1 |
| Mendonça, PR | 1 |
| Amorim, HA | 1 |
| Scorza, CA | 1 |
| Arida, RM | 1 |
| Cavalheiro, EA | 1 |
| Scorza, FA | 1 |
| Borhade, V | 1 |
| Pathak, S | 1 |
| Sharma, S | 1 |
| Patravale, V | 1 |
| Perez, R | 1 |
| Nazarian, Y | 1 |
| Sohmer, H | 1 |
| Sichel, JY | 1 |
| Stevens, DA | 1 |
| Calderon, L | 1 |
| Martinez, M | 1 |
| Clemons, KV | 1 |
| Wilson, SJ | 1 |
| Selitrennikoff, CP | 1 |
| Takei, S | 1 |
| Iseda, T | 1 |
| Yokoyama, M | 1 |
| Cao, MY | 1 |
| Lee, Y | 1 |
| Feng, NP | 1 |
| Al-Qawasmeh, RA | 1 |
| Viau, S | 1 |
| Gu, XP | 1 |
| Lau, L | 1 |
| Jin, H | 1 |
| Wang, M | 1 |
| Vassilakos, A | 1 |
| Wright, JA | 1 |
| Young, AH | 1 |
| Ning, M | 1 |
| Guo, Y | 1 |
| Pan, H | 1 |
| Gu, Z | 1 |
| Usul, H | 1 |
| Cakir, E | 1 |
| Arslan, E | 1 |
| Peksoylu, B | 1 |
| Alver, A | 1 |
| Sayin, OC | 1 |
| Topbas, M | 1 |
| Baykal, S | 1 |
| Clarke, ZL | 1 |
| Moat, SJ | 1 |
| Miller, AL | 1 |
| Randall, MD | 1 |
| Lewis, MJ | 1 |
| Lang, D | 1 |
| Valiant, ME | 1 |
| Frost, BM | 1 |
| Oji, EO | 2 |
| Clayton, YM | 1 |
| Brugnara, C | 2 |
| De Franceschi, L | 2 |
| Armsby, CC | 1 |
| Saadane, N | 1 |
| Trudel, M | 1 |
| Beuzard, Y | 2 |
| Rittenhouse, A | 1 |
| Rifai, N | 1 |
| Platt, O | 1 |
| Alper, SL | 2 |
| Rouyer-Fessard, P | 1 |
| Jouault, H | 1 |
| Sorensen, KN | 1 |
| Wanstrom, AA | 1 |
| Allen, SD | 1 |
| Takemoto, JY | 1 |
| Uchida, K | 1 |
| Ymaguchi, H | 1 |
| Chang, JY | 1 |
| Oh, YK | 1 |
| Kong, HS | 1 |
| Kim, EJ | 1 |
| Jang, DD | 1 |
| Nam, KT | 1 |
| Kim, CK | 1 |
| McRipley, RJ | 1 |
| Erhard, PJ | 1 |
| Schwind, RA | 1 |
| Whitney, RR | 1 |
| Dieppe, PA | 1 |
| Willoughby, DA | 1 |
| Stevens, C | 1 |
| Kirby, JD | 1 |
| Huskisson, EC | 1 |
| Georgiev, VS | 1 |
2 reviews available for clotrimazole and Disease Models, Animal
| Article | Year |
|---|---|
A new therapeutic approach for sickle cell disease. Blockade of the red cell Ca(2+)-activated K+ channel by clotrimazole.
Topics: Administration, Oral; Anemia, Sickle Cell; Animals; Calcium; Clotrimazole; Disease Models, Animal; E | 1995 |
Treatment and developmental therapeutics in aspergillosis. 2. Azoles and other antifungal drugs.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillosis, Allergic Bronchopulmonary; Azoles; Clotrim | 1992 |
33 other studies available for clotrimazole and Disease Models, Animal
| Article | Year |
|---|---|
Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants.
Topics: Animals; Calcium Signaling; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Humans; Hyp | 2009 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Clotrimazole reduces endometriosis and the estrogen concentration by downregulating aromatase.
Topics: Animals; Aromatase; Clotrimazole; Disease Models, Animal; Down-Regulation; Endometriosis; Endometriu | 2020 |
Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cell Proliferation; Cell Survival; Clotrimazole; Dise | 2018 |
Effects of miconazole/clotrimazole and praziquantel combinations against the liver fluke Opisthorchis felineus in vivo and in vitro.
Topics: Animals; Anthelmintics; Clotrimazole; Cricetinae; Disease Models, Animal; Drug Therapy, Combination; | 2018 |
Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea.
Topics: Acetamides; Afatinib; Animals; Cell Membrane Permeability; Clotrimazole; Colon; Cystic Fibrosis Tran | 2019 |
Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model.
Topics: Animals; Animals, Genetically Modified; Antineoplastic Agents; Antineoplastic Combined Chemotherapy | 2020 |
Effects of clotrimazol on the acute necrotizing pancreatitis in rats.
Topics: 14-alpha Demethylase Inhibitors; Alanine Transaminase; Amylases; Animals; Blood Pressure; Bronchoalv | 2013 |
Small-Molecule targeting of translation initiation for cancer therapy.
Topics: Animals; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chroma | 2013 |
The in vitro and in vivo antitumor effects of clotrimazole on oral squamous cell carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Li | 2014 |
Re: Usul H, Arslan E, Cansever T, et al. Effects of clotrimazole on experimental spinal cord ischemia/reperfusion injury in rats. Spine 2008;33:2863-7.
Topics: Animals; Aorta, Abdominal; Clotrimazole; Disease Models, Animal; Neuroprotective Agents; Rats; Renal | 2009 |
Pregnane X receptor activation protects rat hepatocytes against deoxycholic acid-induced apoptosis.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Cholagogues and Choleretics; Clotrimazole; Cytop | 2010 |
Anti-apoptotic pro-survival effect of clotrimazole in a normothermic ischemia reperfusion injury animal model.
Topics: Animals; Antifungal Agents; Apoptosis; bcl-X Protein; Cell Survival; Clotrimazole; Disease Models, A | 2011 |
Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke.
Topics: Animals; Cell Culture Techniques; Cell Death; Cell Hypoxia; Cells, Cultured; Clotrimazole; Culture M | 2011 |
Animal study results suggest that an antifungal drug works against neuronal loss in epilepsy.
Topics: Animals; Antifungal Agents; Cell Death; Clotrimazole; Disease Models, Animal; Drug Evaluation, Precl | 2012 |
Clotrimazole nanoemulsion for malaria chemotherapy. Part II: stability assessment, in vivo pharmacodynamic evaluations and toxicological studies.
Topics: Animals; Antimalarials; Clotrimazole; Disease Models, Animal; Drug Stability; Drug Storage; Emulsion | 2012 |
The effect of topically applied antimycotic agents on inner ear vestibular and cochlear function.
Topics: Animals; Antifungal Agents; Clotrimazole; Cochlea; Disease Models, Animal; Ear, Inner; Evoked Potent | 2013 |
Zeamatin, clotrimazole and nikkomycin Z in therapy of a Candida vaginitis model.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Antifungal Agents; Candida albicans; Candidiasis, V | 2002 |
Inhibitory effect of clotrimazole on angiogenesis associated with bladder epithelium proliferation in rats.
Topics: Animals; Base Sequence; Butylhydroxybutylnitrosamine; Cell Division; Clotrimazole; Disease Models, A | 2003 |
NC381, a novel anticancer agent, arrests the cell cycle in G0-G1 and inhibits lung tumor cell growth in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycle Proteins; Cel | 2004 |
Preparation, in vitro and in vivo evaluation of liposomal/niosomal gel delivery systems for clotrimazole.
Topics: Acrylic Resins; Administration, Intravaginal; Animals; Antifungal Agents; Candidiasis; Clotrimazole; | 2005 |
Effects of clotrimazole on experimental spinal cord injury.
Topics: Animals; Anti-Infective Agents, Local; Clotrimazole; Disease Models, Animal; Drug Evaluation, Precli | 2006 |
Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia.
Topics: Animals; Clotrimazole; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationsh | 2006 |
An experimental model for evaluation of antifungal agents in a Trichophyton mentagrophytes infection of guinea pigs.
Topics: Animals; Antifungal Agents; Clotrimazole; Disease Models, Animal; Female; Griseofulvin; Guinea Pigs; | 1984 |
Development of quantitative methods of measuring antifungal drug effects in the rabbit cornea.
Topics: Animals; Candidiasis; Clotrimazole; Cornea; Corneal Diseases; Disease Models, Animal; Miconazole; Mi | 1981 |
The role of econazole in the management of oculomycosis.
Topics: Animals; Candidiasis; Clotrimazole; Corneal Diseases; Disease Models, Animal; Econazole; Fungi; Imid | 1982 |
Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a beta thalassemic mouse: a model for human therapy.
Topics: Animals; beta-Thalassemia; Body Water; Calcimycin; Calcium; Calcium Channel Blockers; Chlorides; Clo | 1996 |
Efficacy of syringomycin E in a murine model of vaginal candidiasis.
Topics: Animals; Antifungal Agents; Candidiasis, Vulvovaginal; Chromatography, High Pressure Liquid; Clotrim | 1998 |
[Therapeutic efficacy of a topical antifungal solution preparation formulated with pyrrolnitrin and clotrimazole in combination (Pyroace W) in guinea pig model of tinea pedis].
Topics: Animals; Antifungal Agents; Clotrimazole; Disease Models, Animal; Drug Combinations; Guinea Pigs; Ma | 1999 |
Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis.
Topics: Adhesives; Administration, Intravaginal; Animals; Antifungal Agents; Candida albicans; Candidiasis, | 2002 |
Evaluation of vaginal antifungal formulations in vivo.
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis, Vulvovaginal; Clotrimazole; Disease Model | 1979 |
Symposium on specific therapy for rheumatoid arthritis: specific therapy in new conventional animal models.
Topics: Animals; Arthritis, Rheumatoid; Clotrimazole; Dexamethasone; Disease Models, Animal; Gold; Indometha | 1976 |