clotrimazole has been researched along with B16 Melanoma in 6 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have previously found that clotrimazole (1-(alpha-2-chlorotrityl)imidazole) and bifonazole (1-(alpha-biphenyl-4-ylbenzyl)imidazole), the antifungal azole derivatives, which were recently recognized as calmodulin antagonists, are calmodulin antagonists which most effectively reduce glycolysis and ATP level in B16 melanoma cells." | 3.70 | Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells. ( Beitner, R; Penso, J, 1998) |
| " We investigated here the effect of four different calmodulin antagonists: thioridazine (10-[2-(1-methyl-2-piperidyl) ethyl]-2-methylthiophenothiazine), CGS 9343B (1,3-dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a] [4,1]-benzoxazepin-4-yl)methyl]-4-piperidinyl]-2 H-benzimidazol-2-one (1:1) maleate), clotrimazole (1-(alpha-2-chlorotrityl)imidazole) and bifonazole (1-(alpha-biphenyl-4-ylbenzyl)imidazole), on the levels of glucose 1,6-bisphosphate and fructose 1,6-bisphosphate, the two stimulatory signal molecules of glycolysis, and on ATP content and cell viability in B16 melanoma cells." | 3.69 | Calmodulin antagonists decrease glucose 1,6-bisphosphate, fructose 1,6-bisphosphate, ATP and viability of melanoma cells. ( Beitner, R; Glass-Marmor, L; Morgenstern, H, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bain, LJ | 1 |
| LeBlanc, GA | 1 |
| Ochioni, AC | 1 |
| Imbroisi Filho, R | 1 |
| Esteves, AM | 1 |
| Leandro, JGB | 1 |
| Demaria, TM | 1 |
| do Nascimento Júnior, JX | 1 |
| Pereira-Dutra, FS | 1 |
| Bozza, PT | 1 |
| Sola-Penna, M | 1 |
| Zancan, P | 1 |
| Wang, Z | 1 |
| Xu, F | 1 |
| Hu, J | 1 |
| Zhang, H | 2 |
| Cui, L | 1 |
| Lu, W | 1 |
| He, W | 1 |
| Wang, X | 1 |
| Li, M | 1 |
| Xiong, W | 1 |
| Xie, C | 1 |
| Liu, Y | 1 |
| Zhou, P | 1 |
| Liu, J | 1 |
| Huang, P | 1 |
| Qin, XF | 1 |
| Xia, X | 1 |
| Kaur, A | 1 |
| Jyoti, K | 1 |
| Baldi, A | 1 |
| Jain, UK | 1 |
| Chandra, R | 1 |
| Madan, J | 1 |
| Glass-Marmor, L | 1 |
| Morgenstern, H | 1 |
| Beitner, R | 2 |
| Penso, J | 1 |
6 other studies available for clotrimazole and B16 Melanoma
| Article | Year |
|---|---|
Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane; Doxorubicin; Genes, | 1996 |
Clotrimazole presents anticancer properties against a mouse melanoma model acting as a PI3K inhibitor and inducing repolarization of tumor-associated macrophages.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Polarity; Cell Proliferation; Clotrimazole; H | 2021 |
Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.
Topics: Animals; Antineoplastic Agents; Basic-Leucine Zipper Transcription Factors; Cell Line, Tumor; Clotri | 2021 |
Self-assembled nanomicelles of amphiphilic clotrimazole glycyl-glycine analogue augmented drug delivery, apoptosis and restrained melanoma tumour progression.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Line, Tumor; Clotrimazole; Drug Carrie | 2018 |
Calmodulin antagonists decrease glucose 1,6-bisphosphate, fructose 1,6-bisphosphate, ATP and viability of melanoma cells.
Topics: Adenosine Triphosphate; Animals; Benzimidazoles; Calmodulin; Cell Survival; Clotrimazole; Fructosedi | 1996 |
Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells.
Topics: Animals; Anti-Infective Agents; Antifungal Agents; Calmodulin; Cell Survival; Clotrimazole; Hexokina | 1998 |