clorgyline has been researched along with Serotonin Syndrome in 10 studies
Clorgyline: An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.
clorgyline : An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pre-treatment with diazepam, 10 and 20mg/kg, and chlormethiazole, 50 and 100mg/kg, attenuated the development of hyperthermia." | 5.32 | Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Takano, K; Yoshino, T, 2003) |
| "Pretreatment with risperidone (0." | 5.32 | Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Takano, K; Yoshino, T, 2004) |
| " The 5-HT1A antagonist WAY 100635 decreased 5-HTP-induced hypothermia in SERT+/+ and +/- mice with no effect in SERT-/- mice, whereas the 5-HT7 antagonist SB 269970 decreased this exaggerated response in SERT-/- mice only." | 3.74 | Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. ( Fox, MA; French, HT; Huang, SJ; Jensen, CL; Murphy, DL; Stein, AR; Tolliver, TJ, 2008) |
| " However, the neural mechanism by which extracellular 5-HT is elevated to a toxic level for the syndrome remains to be determined." | 1.35 | Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome. ( Huang, X; Krishnamoorthy, S; Ma, Z; Tao, R; Vukovich, NP; Zhang, G, 2009) |
| "Pre-treatment with diazepam, 10 and 20mg/kg, and chlormethiazole, 50 and 100mg/kg, attenuated the development of hyperthermia." | 1.32 | Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Takano, K; Yoshino, T, 2003) |
| "Pretreatment with risperidone (0." | 1.32 | Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Takano, K; Yoshino, T, 2004) |
| "Pretreatment with propranolol (10 mg/kg), a 5-HT(1A) receptor antagonist as well as a beta-blocker, and dantrolene (20 mg/kg), a peripheral muscle relaxant, did not prevent the death of the animals, even though these two drugs suppressed the increase in rectal temperature to some extent." | 1.31 | Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. ( Katoh, S; Nisijima, K; Yoshino, T; Yui, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (80.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fox, MA | 1 |
| Jensen, CL | 1 |
| French, HT | 1 |
| Stein, AR | 1 |
| Huang, SJ | 1 |
| Tolliver, TJ | 1 |
| Murphy, DL | 1 |
| Zhang, G | 3 |
| Krishnamoorthy, S | 3 |
| Ma, Z | 3 |
| Vukovich, NP | 1 |
| Huang, X | 1 |
| Tao, R | 3 |
| Wei, J | 1 |
| Auerbach, SB | 1 |
| Shioda, K | 3 |
| Nisijima, K | 5 |
| Kasai, M | 1 |
| Yoshino, T | 5 |
| Kato, S | 3 |
| Takano, K | 2 |
| Izumi, T | 1 |
| Iwamoto, N | 1 |
| Kitaichi, Y | 1 |
| Kato, A | 1 |
| Inoue, T | 1 |
| Koyama, T | 1 |
| Jenney, C | 1 |
| Ishiguro, T | 1 |
| Yui, K | 1 |
| Katoh, S | 1 |
10 other studies available for clorgyline and Serotonin Syndrome
| Article | Year |
|---|---|
Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Brain Chemistry; Catech | 2008 |
Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Body Temperature; Clorgyline; Cyproheptadine; D | 2009 |
Involvement of 5-HT2A receptors in the serotonin (5-HT) syndrome caused by excessive 5-HT efflux in rat brain.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Brain; Clorgyline; Hypothermia, Induced; Ketanserin; | 2010 |
Risperidone attenuates the increase of extracellular nitric oxide and glutamate levels in serotonin syndrome animal models.
Topics: 5-Hydroxytryptophan; Animals; Brain; Clorgyline; Disease Models, Animal; Fluoxetine; Glutamic Acid; | 2012 |
Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Brain; Chlormethiazole; Clorgyline; Diazepam; Diseas | 2003 |
Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Clorgyline; Disease Models, Animal; Dizocilpine Male | 2004 |
Effects of co-administration of a selective serotonin reuptake inhibitor and monoamine oxidase inhibitors on 5-HT-related behavior in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Clorgyline; Dose-Response Relationship, Drug | 2006 |
Characterization of serotonin-toxicity syndrome (toxidrome) elicited by 5-hydroxy-l-tryptophan in clorgyline-pretreated rats.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Clorgyline; Cyproheptadine; Dizocilpine Maleate; Dos | 2008 |
Risperidone counteracts lethality in an animal model of the serotonin syndrome.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Body Temperature; Clorgyline; Disease Models, A | 2000 |
Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome.
Topics: 5-Hydroxytryptophan; Animals; Anterior Hypothalamic Nucleus; Antidepressive Agents; Body Temperature | 2001 |