clorgyline has been researched along with Neuroblastoma in 7 studies
Clorgyline: An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.
clorgyline : An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), its oxidized metabolite, and two recently synthesized 2'-alkyl derivatives of MPTP (methyl and ethyl), found to be more toxic in vivo in mice, have been compared in two neuroblastoma hybrid cell lines (NCB-20 and 140-3) that express the B form of monoamine oxidase (MAO), as tissue culture models for the mode of action of MPTP in the central nervous system." | 3.68 | Toxicity of MPTP and structural analogs in clonal cell lines of neuronal origin expressing B type monoamine oxidase activity. ( Buckman, TD, 1991) |
| "Given that carriers of certain Alzheimer's disease (AD)-related PS-1 variants are predisposed to clinical depression and that depression has been historically associated with the mitochondrial enzyme, monoamine oxidase-A (MAO-A), we investigated cortical MAO-A function in the AD-related PS-1(M146V) knock-in mouse." | 1.38 | Monoamine oxidase-A physically interacts with presenilin-1(M146V) in the mouse cortex. ( Baker, GB; Cao, X; Chlan-Fourney, J; Gabriel, GG; Mousseau, DD; Nazarali, AJ; Pennington, PR; Rui, L; Wei, Z, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Zindo, FT | 1 |
| Malan, SF | 1 |
| Omoruyi, SI | 1 |
| Enogieru, AB | 1 |
| Ekpo, OE | 1 |
| Joubert, J | 1 |
| Jismy, B | 1 |
| El Qami, A | 1 |
| Pišlar, A | 1 |
| Frlan, R | 1 |
| Kos, J | 1 |
| Gobec, S | 1 |
| Knez, D | 1 |
| Abarbri, M | 1 |
| Wei, Z | 1 |
| Gabriel, GG | 1 |
| Rui, L | 1 |
| Cao, X | 1 |
| Pennington, PR | 1 |
| Chlan-Fourney, J | 1 |
| Nazarali, AJ | 1 |
| Baker, GB | 1 |
| Mousseau, DD | 1 |
| Hawkins, M | 1 |
| Wallace, DC | 1 |
| Eisenstadt, JM | 1 |
| Breakefield, XO | 1 |
| Willets, JM | 1 |
| Lambert, DG | 1 |
| Lunec, J | 1 |
| Griffiths, HR | 1 |
| Donnelly, CH | 1 |
| Richelson, E | 1 |
| Murphy, DL | 1 |
| Buckman, TD | 1 |
7 other studies available for clorgyline and Neuroblastoma
| Article | Year |
|---|---|
Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents.
Topics: Cell Line, Tumor; Drug Design; Humans; Monoamine Oxidase; Neuroblastoma; Neuroprotective Agents; Par | 2019 |
Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.
Topics: Antiparkinson Agents; Bromides; Coordination Complexes; Humans; Indazoles; Metals; Molecular Docking | 2021 |
Monoamine oxidase-A physically interacts with presenilin-1(M146V) in the mouse cortex.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Cells, Cultured; Cerebral Cortex; Chromatography, | 2012 |
Expression of monoamine oxidase A and B activities in mouse cybrids and hybrids.
Topics: Animals; Cell Fusion; Cell Line; Clorgyline; Hybrid Cells; L Cells; Liver Neoplasms, Experimental; M | 1981 |
Studies on the neurotoxicity of 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) in SH-SY5Y cells.
Topics: Adenylyl Cyclases; Adrenergic Uptake Inhibitors; Catecholamines; Cell Death; Clorgyline; Dose-Respon | 1995 |
Properties of monoamine oxidase in mouse neuroblastoma N1E-115 cells.
Topics: Animals; Blood Platelets; Brain; Cells, Cultured; Clorgyline; Ganglia, Spinal; Humans; Kinetics; Mon | 1976 |
Toxicity of MPTP and structural analogs in clonal cell lines of neuronal origin expressing B type monoamine oxidase activity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Survival; Clone Cells; Clorgyline; Isoen | 1991 |