clorgyline has been researched along with Lesch-Nyhan Syndrome in 2 studies
Clorgyline: An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.
clorgyline : An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castro Costa, MR | 1 |
| Edelstein, SB | 1 |
| Castiglione, CM | 2 |
| Chao, H | 1 |
| Breakefield, XO | 2 |
| Roth, JA | 1 |
2 other studies available for clorgyline and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Properties of monoamine oxidase in control and Lesch-Nyhan fibroblasts.
Topics: Adolescent; Adult; Age Factors; Cells, Cultured; Child; Child, Preschool; Clorgyline; Female; Fibrob | 1980 |
Monoamine oxidase and catechol-O-methyltransferase activities in cultured human skin fibroblasts.
Topics: Catechol O-Methyltransferase; Cells, Cultured; Clorgyline; Fibroblasts; Humans; Hypoxanthine Phospho | 1976 |