clorgyline has been researched along with Acute Confusional Senile Dementia in 34 studies
Clorgyline: An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.
clorgyline : An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alzheimer's disease is a progressive brain disorder with characteristic symptoms and several pathological hallmarks." | 1.62 | 2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease. ( Andrys, R; Capek, J; Handl, J; Hrabinova, M; Janockova, J; Kobrlova, T; Korabecny, J; Marco-Contelles, JL; Mezeiova, E; Micankova, P; Muckova, L; Nepovimova, E; Pejchal, J; Rousar, T; Simunkova, M; Soukup, O; Valko, M, 2021) |
| "In the brains of patients with Alzheimer's disease, the enzymatic activities of butyrylcholinesterase (BChE) and monoamine oxidase B (MAO-B) are increased." | 1.46 | N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents. ( Brazzolotto, X; Brus, B; Colletier, JP; Coquelle, N; Gobec, S; Knez, D; Kos, J; Košak, U; Nachon, F; Pišlar, A, 2017) |
| "Considering the complex etiology of Alzheimer's disease (AD), multifunctional agents may be beneficial for the treatment of this disease." | 1.46 | DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy. ( Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y, 2017) |
| "Given that carriers of certain Alzheimer's disease (AD)-related PS-1 variants are predisposed to clinical depression and that depression has been historically associated with the mitochondrial enzyme, monoamine oxidase-A (MAO-A), we investigated cortical MAO-A function in the AD-related PS-1(M146V) knock-in mouse." | 1.38 | Monoamine oxidase-A physically interacts with presenilin-1(M146V) in the mouse cortex. ( Baker, GB; Cao, X; Chlan-Fourney, J; Gabriel, GG; Mousseau, DD; Nazarali, AJ; Pennington, PR; Rui, L; Wei, Z, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (5.88) | 29.6817 |
| 2010's | 23 (67.65) | 24.3611 |
| 2020's | 9 (26.47) | 2.80 |
| Authors | Studies |
|---|---|
| Gökhan-Kelekçi, N | 1 |
| Yabanoğlu, S | 1 |
| Küpeli, E | 1 |
| Salgin, U | 1 |
| Ozgen, O | 1 |
| Uçar, G | 1 |
| Yeşilada, E | 1 |
| Kendi, E | 1 |
| Yeşilada, A | 1 |
| Bilgin, AA | 1 |
| Huang, L | 5 |
| Lu, C | 3 |
| Sun, Y | 2 |
| Mao, F | 2 |
| Luo, Z | 2 |
| Su, T | 2 |
| Jiang, H | 1 |
| Shan, W | 1 |
| Li, X | 6 |
| Zhou, Q | 1 |
| Yan, J | 2 |
| Du, Z | 1 |
| Guo, Y | 1 |
| Luo, HB | 1 |
| Yan, M | 1 |
| Chen, J | 2 |
| Chen, X | 1 |
| Wang, L | 1 |
| Esteban, G | 1 |
| Ojima, M | 1 |
| Bautista-Aguilera, OM | 1 |
| Inokuchi, T | 1 |
| Moraleda, I | 1 |
| Iriepa, I | 1 |
| Samadi, A | 1 |
| Youdim, MB | 1 |
| Romero, A | 1 |
| Soriano, E | 1 |
| Herrero, R | 1 |
| Fernández Fernández, AP | 1 |
| Marco-Contelles, J | 1 |
| Unzeta, M | 1 |
| Xie, S | 1 |
| Wang, Y | 2 |
| Wang, Z | 1 |
| Li, Y | 11 |
| Qiang, X | 9 |
| Luo, L | 8 |
| Xiao, G | 6 |
| Tan, Z | 12 |
| Deng, Y | 13 |
| Joubert, J | 1 |
| Foka, GB | 1 |
| Repsold, BP | 1 |
| Oliver, DW | 1 |
| Kapp, E | 1 |
| Malan, SF | 1 |
| Košak, U | 1 |
| Knez, D | 1 |
| Coquelle, N | 1 |
| Brus, B | 1 |
| Pišlar, A | 1 |
| Nachon, F | 1 |
| Brazzolotto, X | 1 |
| Kos, J | 1 |
| Colletier, JP | 1 |
| Gobec, S | 1 |
| Yang, X | 6 |
| Zheng, Y | 5 |
| Cao, Z | 10 |
| Sang, Z | 6 |
| Su, F | 2 |
| Liu, Q | 1 |
| Ai, J | 1 |
| Xu, R | 6 |
| Song, Q | 7 |
| Pan, W | 1 |
| Wang, K | 3 |
| Ma, Q | 2 |
| Yu, L | 2 |
| Liu, W | 3 |
| Wang, H | 3 |
| Han, X | 1 |
| Ye, M | 1 |
| Xu, YX | 1 |
| Li, XK | 1 |
| Dong, SN | 1 |
| Liu, WW | 1 |
| Gong, Q | 1 |
| Wang, TD | 1 |
| Tang, Y | 1 |
| Zhu, J | 1 |
| Li, J | 1 |
| Zhang, HY | 1 |
| Yang, J | 1 |
| Zhang, X | 2 |
| Liu, H | 2 |
| Yang, Z | 2 |
| Reis, J | 1 |
| Cagide, F | 1 |
| Valencia, ME | 1 |
| Teixeira, J | 1 |
| Bagetta, D | 2 |
| Pérez, C | 1 |
| Uriarte, E | 1 |
| Oliveira, PJ | 1 |
| Ortuso, F | 1 |
| Alcaro, S | 2 |
| Rodríguez-Franco, MI | 1 |
| Borges, F | 1 |
| Kumar, B | 1 |
| Kumar, V | 2 |
| Prashar, V | 1 |
| Saini, S | 1 |
| Dwivedi, AR | 1 |
| Bajaj, B | 1 |
| Mehta, D | 1 |
| Parkash, J | 1 |
| Yu, G | 2 |
| Liu, Z | 2 |
| Bai, P | 1 |
| Wu, A | 1 |
| Shi, J | 1 |
| Zhu, G | 1 |
| Lan, Y | 1 |
| Chen, Z | 2 |
| Zhao, Y | 1 |
| Qiao, Z | 1 |
| Wang, C | 1 |
| Xie, SS | 1 |
| Liu, J | 2 |
| Tang, C | 2 |
| Pang, C | 2 |
| Li, Q | 1 |
| Qin, Y | 1 |
| Nong, X | 1 |
| Zhang, Z | 1 |
| Guo, J | 2 |
| Cheng, M | 1 |
| Tang, W | 1 |
| Liang, N | 1 |
| Jiang, N | 2 |
| Mezeiova, E | 1 |
| Janockova, J | 1 |
| Andrys, R | 1 |
| Soukup, O | 1 |
| Kobrlova, T | 1 |
| Muckova, L | 1 |
| Pejchal, J | 1 |
| Simunkova, M | 1 |
| Handl, J | 1 |
| Micankova, P | 1 |
| Capek, J | 1 |
| Rousar, T | 1 |
| Hrabinova, M | 1 |
| Nepovimova, E | 1 |
| Marco-Contelles, JL | 1 |
| Valko, M | 1 |
| Korabecny, J | 1 |
| Cong, S | 1 |
| Zhang, L | 1 |
| Moutayakine, A | 1 |
| Marques, C | 1 |
| López, Ó | 1 |
| Leitzbach, L | 1 |
| Hagenow, S | 1 |
| Carreiro, EP | 1 |
| Stark, H | 1 |
| Fernández-Bolaños, JG | 1 |
| Burke, AJ | 1 |
| Zhong, G | 1 |
| Su, D | 1 |
| Jing, L | 1 |
| Zhang, F | 1 |
| He, P | 1 |
| Yan, Y | 1 |
| Wei, Z | 1 |
| Gabriel, GG | 1 |
| Rui, L | 1 |
| Cao, X | 1 |
| Pennington, PR | 1 |
| Chlan-Fourney, J | 1 |
| Nazarali, AJ | 1 |
| Baker, GB | 1 |
| Mousseau, DD | 1 |
| Dell'Antone, P | 1 |
| IbnLkayat, M | 1 |
| Drago, D | 1 |
| Zatta, P | 1 |
34 other studies available for clorgyline and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.
Topics: Alzheimer Disease; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Hindlimb; Hydrogen Bonding; | 2007 |
Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Antioxidants; Benzylidene Compounds; Cations, Div | 2012 |
A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Dose-Response Relationship, Drug; En | 2013 |
Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cholinesterase | 2013 |
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Electro | 2013 |
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Chelating Agents; Cholinesterase Inhibitors; Donep | 2014 |
Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cations, Divalent; Cell Membrane Permeabilit | 2015 |
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Blood-Brain Barrier; C | 2016 |
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzyl Compounds; Binding Sites; Cholinesterase I | 2017 |
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Death; Cell Line; Cholinestera | 2017 |
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug | 2017 |
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; D | 2017 |
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Chalcones; Cholinesterase Inh | 2017 |
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Bloo | 2017 |
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cholinesterase Inhibitors | 2017 |
Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Chelating Agents; Cholinesterase Inh | 2017 |
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholin | 2017 |
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzophenones; Binding Sites; Blood- | 2017 |
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; | 2018 |
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Line; Cell Surviva | 2018 |
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Blood-Br | 2018 |
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.
Topics: Alzheimer Disease; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Chromones; Drug | 2018 |
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase.
Topics: Acetylcholinesterase; Alkynes; Alzheimer Disease; Catalytic Domain; Cell Line, Tumor; Cholinesterase | 2019 |
Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Clioquinol; Drug Discovery; Flurbiprofen; Humans; Ligands; | 2020 |
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amines; Amyloid beta-Peptides; Animals; Butyrylcholinestera | 2020 |
Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amides; Amyloid beta-Peptides; Animals; Cell Line; Cell Survival; Disease Models, | 2020 |
Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Clorgyline; Dose | 2020 |
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Drug Design; Humans; Naphthoquinones; Structure-Activity Relationship | 2021 |
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; | 2021 |
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amines; Amyloid beta-Peptides; Animals; Antioxidants; Bindi | 2021 |
Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Horses; Kinetics; Mole | 2022 |
Novel AP2238-clorgiline hybrids as multi-target agents for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cholinesterases; Clorgy | 2023 |
Monoamine oxidase-A physically interacts with presenilin-1(M146V) in the mouse cortex.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Cells, Cultured; Cerebral Cortex; Chromatography, | 2012 |
Acidic vesicles of the endo-exocytic pathways as targets for some anti-monoamine oxidase drugs.
Topics: Acid-Base Equilibrium; Acids; Alzheimer Disease; Amantadine; Animals; Brain; Brain Chemistry; Brain | 2009 |