cloprostenol and Placenta--Retained

Two experiments were designed to determine whether pretreatment with triamcinolone acetonide (TRI)prior to induction of parturition with dexamethasone(DEX) and cloprostenol (CLO) would reduce the incidence of retained placenta. Experiment 1 was conducted to determine the optimum dosage of TRI and to approximate the optimum interval from TRI to induction with DEX+CLO. All cows received TRI on day 270 of gestation. Cows in group I received 1 mg/30 kg of body weight (BW) of TRI and were induced to calve with DEX+CLO on day 276. Cows in groups II and III received 1 mg/45 kg BW and were induced on days 276 or 277, respectively. Cows in groups IV and V received 1 mg/60 kg BW and were induced on days 277 or 278, respectively. Group VI cows served as untreated controls. There was no difference in the incidence of retained placenta among the treated and control groups. Experiment 2 was conducted to more precisely determine the optimum interval from pretreatment to induction treatment with the chosen dose of TRI. All cows in groups I, II, and III were pretreated with 1 mg/60 kg BW of TRI on day 270 of gestation and received DEX+CLO on days 275, 276 or 277,respectively. Group IV cows served as untreated controls. The incidence of retained placenta was higher (p < 0.05) in groups I and II than in the control group, with group III intermediate and not different from the others. Cows that retained their placentas had higher (p < 0.05) body temperatures from day 2 to day 7 after calving and tended to have a lower pregnancy rate in the subsequent breeding season than cows that did not retain their placentas.Results indicate that pretreatment with TRI seven days prior to induction of parturition with DEX+CLO resulted in a reduced incidence of retained placenta,apparently by advancing placental maturation.

Topics: Animals; Body Temperature; Cattle; Cattle Diseases; Cloprostenol; Dexamethasone; Female; Incidence; Labor, Induced; Placenta, Retained; Pregnancy; Premedication; Treatment Outcome; Triamcinolone

In each of 4 years, 94-116 mature cows had two 6-7-day-old embryos, produced by the in vitro fertilisation of oocytes, inserted non-surgically into one uterine horn of each cow. Starting 5 days before the expected date of calving, the cows were continuously observed and assistance at calving was provided when required. In year 1, perinatal calf survival was similar in twin-calving (TC) and single-calving (SC) cows (98.1 versus 100% for calves born to TC and SC, respectively). There was a higher incidence of assistance at birth for TC (52%) than for SC (21%). In years 2 and 3, the calving of 30 SC and 33 TC was synchronised using an injection of Opticortinol (OP) 6-9 days before the injection of Estrumate and Dexol-5 (E+D). A further 34 SC calved naturally. Synchronised calving reduced the spread of calving from 16-25 to 8-9 days without reducing perinatal calf survival and had no significant effect on the incidence of assistance at birth in SC. The TC in years 2 and 3 had a high incidence of retained placenta at 48 h (70%) and a high incidence of assistance at birth (85%). In year 4, calving was synchronised in 16 SC and 21 TC with E+D and no pre-treatment with OP, while 15 SC were treated with both OP and E+D. There were no effects of the hormone treatment on perinatal calf survival and only small effects on the incidence of assisted births for SC. The incidence of retained placenta at 48 h was lower for SC pre-treated with OP (40%) than for SC (88%) and TC (76%) not pre-treated with OP. Continuous supervision over calving produced perinatal calf survival rates for TC that were similar to SC, despite the higher incidence of assistance of TC at parturition. Hormonal synchronisation of calving can halve the time required for continuous supervision of calving, but the hormone treatments exacerbate the already high incidence of retained placenta in TC.

Topics: Adrenal Cortex Hormones; Animals; Animals, Newborn; Cattle; Cloprostenol; Embryo Transfer; Estrus Synchronization; Female; Fetal Death; Gestational Age; Incidence; Labor, Induced; Obstetric Labor Complications; Placenta, Retained; Pregnancy; Pregnancy Outcome; Pregnancy, Animal; Pregnancy, Multiple; Reproduction; Survival Analysis; Time Factors; Twins