clopidogrel has been researched along with Thrombosis in 912 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.11) | 18.7374 |
| 1990's | 24 (2.63) | 18.2507 |
| 2000's | 326 (35.75) | 29.6817 |
| 2010's | 481 (52.74) | 24.3611 |
| 2020's | 80 (8.77) | 2.80 |
| Authors | Studies |
|---|---|
| Andersen, SM; Antonsson, T; Bach, P; Björkman, JA; Bylund, R; Giordanetto, F; Österlund, K; van Giezen, JJ; Zachrisson, H; Zetterberg, F | 1 |
| Bostwick, JS; Chacko, SA; Chen, BC; Chen, XQ; Clark, CG; Hiebert, S; Hua, J; Huang, CS; Jeon, YT; Lam, PY; Levesque, PC; Li, D; Li, L; Liu, Y; Malley, M; Mathur, A; Price, LA; Qiao, JX; Rehfuss, R; Ruel, R; Schumacher, WA; Seiffert, DA; Shen, H; Stewart, AB; Sun, D; Thibeault, C; Wang, TC; Wang, Y; Wexler, RR; Wong, HS; Wu, DR; Yang, W; Zhu, J | 1 |
| Chen, XQ; Crain, E; Hua, J; Huang, CS; Lai, A; Lam, PY; Price, LA; Qiao, JX; Rehfuss, R; Seiffert, DA; Shen, H; Wang, TC; Wang, Y; Watson, C; Wexler, RR; Wong, P; Yang, W | 1 |
| Badorc, A; Barré, G; Besse, A; Boldron, C; Bonnet-Lignon, S; Bono, F; Bordes, MF; Briot, C; Delesque, N; Dol, F; Fossey, V; Gau, B; Hérault, JP; Herbert, JM; Lassalle, G; Meneyrol, J; Millet, L; Nazare, M; Pflieger, AM; Rousseaux, T; Savi, P; Tissandié, S; Yvon, X; Zech, G | 1 |
| Anil Kumar, KS; Bajaj, K; Barthwal, MK; Dikshit, DK; Dikshit, M; Jain, M; Misra, A; Shandilya, S; Shukla, P; Srivastava, S | 1 |
| Bai, N; Chen, C; Chen, P; Fu, H; Guo, Y; Lam, YPY; Li, M; Li, W; Malhotra, S; O'Connor, PB; Wu, Q; Zhang, D | 1 |
| Balapragalathan, TJ; Banville, J; Bouvier, M; Callejo, M; Cvijic, ME; Deon, D; Dubé, L; Gagnon, M; Gordon, DA; Guarino, VR; Guay, J; Gupta, A; Guy, J; Hua, J; Lapointe, P; Lavallée, JF; Li, J; Marinier, A; Martel, A; Mathur, A; Plamondon, S; Posy, SL; Priestley, ES; Rémillard, R; Richter, JM; Ruediger, E; Sum, CS; Tremblay, F; Vetrichelvan, M; Watson, C; Wexler, RR; Wong, P; Yang, J | 1 |
| Bressi, E; Capuano, M; Cavallari, I; Colaiori, I; Di Sciascio, G; Grigioni, F; Mangiacapra, F; Ricottini, E; Spoto, S; Sticchi, A; Ussia, GP; Viscusi, MM | 1 |
| Chen, X; Deng, F; Liu, H; Qin, L; Wang, W; Zhu, W | 1 |
| Bree, KK; Dinney, CP; Hensley, PJ; Kamat, AM; Lobo, N; Navai, N; Nogueras-Gonzalez, GM | 1 |
| Bhatt, DL; Cavender, MA; Deliargyris, EN; Gibson, CM; Hamm, CW; Harrington, RA; Leonardi, S; Lopes, RD; Mahaffey, KW; Prats, J; Price, MJ; Steg, PG; Stone, GW; White, HD | 1 |
| Doran, T; Keles, EC; Kirac, D; Mihmanli, M; Yaman, AE | 1 |
| Atassi, B; Baumann Kreuziger, L; Berger, JS; Berry, S; Bochicchio, G; Cheng, Y; Cushman, M; de Oliveira Antunes, M; Farkouh, ME; Gong, MN; Greenstein, Y; Hade, EM; Hochman, JS; Hudock, K; Hyzy, R; Khatri, P; Kim, KS; Kindzelski, A; Kirwan, BA; Kornblith, LZ; Lawler, PR; Leifer, E; Lopes, RD; Lopez-Sendon Moreno, J; Lopez-Sendon, J; Luther, JF; McVerry, BJ; Neal, MD; Nigro Maia, L; Quigley, J; Reynolds, HR; Sherwin, R; Wahid, L; Wilson, J | 1 |
| Chaturvedi, S; Hussain, H; McCrae, KR; Roberts, JC; Tarantino, MD | 1 |
| De Luca, L; Ferraro, PM; Gabrielli, D; Grigioni, F; Mangiacapra, F; Mangiacapra, R; Melfi, R; Nusca, A; Paolucci, L; Ussia, GP; Viscusi, MM | 1 |
| Bai, N; Ma, Y; Niu, Y; Shang, YS; Wang, ZL; Zhong, PY | 1 |
| Bergh, N; Myredal, A; Nivedahl, P; Petzold, M; Wallerstedt, SM; Wartenberg, C; Zarin, S | 1 |
| Bergmeier, W; Cooley, BC; Holle, LA; Kawano, T; Lee, RH; Mackman, N; Mwiza, JMN; Nieswandt, B; Paul, DS; Schug, WJ; Wolberg, AS | 1 |
| Brooks, MB; Goggs, R; Lynch, AM; Tracy, AL | 1 |
| Abdulhakim Ali, M; Abdullah Ali Rahhal, A; Baki Jasem Senjar, A; Ede, H; Fares Alhaj Issa, A; Mehdar Al-Saadi Al Yafei, S; Rahman Mohammad Said Arabi, A; Razaq Al-Qahtani, A; Salah Shabib Ahmed, H; Sobhy Hassan Ghonim Mahfouz, A | 1 |
| Chilbert, MR; Denny, O; Mills, K; Woodruff, AE | 1 |
| Chen, C; Chen, Z; Gu, X; Liu, W; Mao, X; Ren, S; Tao, L; Zhang, L; Zhao, Y | 1 |
| Gersh, BJ; Holmes, DR; Kandlakunta, H; Kochar, A; Kuchkuntla, AR; Murad, MH; Patlolla, SH; Rab, ST; Vallabhajosyula, S; Wang, Z; West, CP; Zhao, DX | 1 |
| Bai, C; Chen, Z; Ding, Y; Ilagan, R; Ji, X; Meng, R; Wu, X | 1 |
| Cao, Z; Dong, S; Guo, S; Liu, G; Shen, J; Sheng, L; Sun, X; Tian, Y; Wu, G | 1 |
| Kuszynski, DS; Lauver, DA | 1 |
| Kozieł-Siołkowska, M; Lip, GY; Shantsila, E | 1 |
| Adang, E; Coenen, M; Deneer, V; Donders, R; Kramers, C; Kranendonk, J; Reijnen, M; Vijver-Coppen, RV; Warlé, MC; Willems, LH; Zeebregts, CJ | 1 |
| DeCarlo, C; Dua, A; Feldman, ZM; Kim, Y; Kirshkaln, A; Lella, S; Levine, E; Majumdar, M; McElroy, I; Nuzzolo, K; Poyant, J; Waller, D | 1 |
| Han, K; Huang, X; Ma, M; Sun, T; Yang, S; Zhao, Z; Zhou, Y | 1 |
| Ge, T; Song, EJ; Tang, S; Wang, J; Zhou, W; Zhu, Z | 1 |
| Chen, M; Cheng, K; Ge, J; Huang, J; Lan, J; Li, G; Qian, J; Wang, X; Wang, Y; Wei, G; Wu, H; Xu, L; Zhang, C; Zhang, H; Zhao, X | 1 |
| Bae, JW; Han, JK; Hur, SH; Hwang, D; Kang, J; Kim, HS; Koo, BK; Lee, H; Lee, NH; Park, KW; Rha, SW; Shin, ES; Yang, HM | 1 |
| Arthur, JM; Arulprakash, N; Corken, A; Dai, J; Davis, O; Hedayati, SS; Jain, N; Mehta, JL; Phadnis, MA; Rahmatallah, Y; Smyth, S; Ware, J | 1 |
| Jin, H; Liang, Q; Shen, X; Song, J; Sun, G; Yu, Y | 1 |
| Ago, T; Fukuda, K; Fukushima, Y; Kitazono, T; Kitsuki, S; Matsushita, T | 1 |
| Qin, Y; Wang, H; Xiao, G; Xu, L | 1 |
| Baber, U; Cao, D; Chiarito, M; Dangas, G; DeFranco, A; Effron, MB; Henry, TD; Kapadia, S; Keller, S; Kini, A; Mehran, R; Pocock, S; Rao, SV; Sartori, S; Sharma, S; Smith, KF; Spirito, A; Stefanini, G; Strauss, C; Toma, C; Vogel, B; Weintraub, W; Zhang, Z | 1 |
| Farag, A; Hamabe, L; Mandour, AS; Matsumoto, K; Tanaka, R; Uemura, A; Yoshida, T | 1 |
| Baas, L; Gawaz, MP; Geisler, T; Gekeler, S; Harm, T; Kreisselmeier, KP; Müller, II; Müller, KAL; Prang, C; Rath, D; Schröder, S | 1 |
| Aradi, D; Hille, L; Leggewie, S; Nührenberg, TG; Schrör, K; Sibbing, D; Stratz, C; Trenk, D | 1 |
| Grajek, S; Michalak, M; Olasińska-Wiśniewska, A; Ritter, SS | 1 |
| Davis, BH; DeFrank, G; Harada, S; Limdi, NA | 1 |
| Bolognese, L; Cantor, WJ; Cequier, Á; Chettibi, M; Collet, JP; Diallo, A; Ecollan, P; Fabris, E; Goodman, SG; Hamm, CW; Hammett, CJ; Hermanides, RS; Huber, K; Janzon, M; Lapostolle, F; Lassen, JF; Merkely, B; Montalescot, G; Silvain, J; Storey, RF; Tavenier, AH; Ten Berg, JM; van 't Hof, AWJ; Vicaut, E; Willems, FF; Zeymer, U | 1 |
| Hayashi, K; Honma, M; Iinuma, S; Ishida-Yamamoto, A; Kanno, K; Kinouchi, M; Nagasawa, Y; Obata, M; Sasaki, K; Sugawara, M | 1 |
| Gorog, DA; Gue, YX; Kanji, R; Srinivasan, M; Wellsted, DM; Wyatt, S | 1 |
| Andò, G; Trio, O | 1 |
| Ajjan, RA; Barwari, T; Grant, PJ; Mayr, M; Parker, WAE; Pearson, SM; Phoenix, F; Schulte, C; Storey, RF | 1 |
| Ben-Yehuda, O; Claessen, BE; Crowley, A; Faggioni, M; Farhan, S; Généreux, P; Kirtane, AJ; Maehara, A; Mastoris, I; Mehran, R; Redfors, B; Stone, GW; Weisz, G; Witzenbichler, B | 1 |
| Bocchino, PP; D'Ascenzo, F; De Ferrari, GM; De Filippo, O; Imazio, M; Piroli, F; Scacciatella, P | 1 |
| Lin, Z; Liu, L; Xuan, J; Yang, X; Zhang, L | 1 |
| Cao, X; Gu, J; Li, X; Liu, P; Miao, Y; Sun, D; Xu, Z; Zhang, J | 1 |
| Brennan, MM; Corliss, BM; Fox, WC; Freedman, R; Harris, NS; Hoh, BL; Nerva, JD; Polifka, AJ; Smith, J | 1 |
| Masarova, L; Novak, J; Ondrasek, J; Panovsky, R; Pesl, M; Semenka, J; Simarova, E | 1 |
| Ajjan, RA; Naseem, KM; Sagar, RC | 1 |
| Hugenberg, DW; Kreutz, RP; Mshelbwala, FS | 1 |
| Dickson, SD; Govea, A; Penny, W; Taleb, A; Wiernek, S | 1 |
| Ben-Dor, I; Chen, Y; Gajanana, D; Iantorno, M; Khalid, N; Khan, JM; Kolm, P; Musallam, A; Rogers, T; Satler, LF; Shlofmitz, E; Torguson, R; Waksman, R; Weintraub, WS; Zhang, C | 1 |
| Juvet, F; Kelly, D; Moore, G | 1 |
| Chen, S; Jiang, J; Wu, Q; Wu, X; Wu, Z; Yan, H; Ye, F; You, W | 1 |
| Cao, SP; Zheng, P; Zhong, HL; Zhou, MC | 1 |
| Gounis, MJ; Henkes, H; King, RM; Langan, ET; Puri, AS; Raskett, CM; Ughi, GJ | 1 |
| Di, Y; Guo, T; Hou, J; Kong, F; Li, Y; Ming, JE; Ping, C; Wang, L; Xie, F; Yang, N; Yin, H; Zhang, L | 1 |
| Chen, X; Gong, S; Hu, C; Hu, X; Li, L; Pei, T; Yang, J; Zhang, L | 1 |
| Bonello, L; Burtey, S; Canault, M; Cayla, G; Laine, M; Lemesle, G; Paganelli, F; Pankert, M; Puymirat, E; Quaino, G; Range, G | 1 |
| Åkerblom, A; Baheti, S; Bielinski, SJ; Black, JL; Eckloff, BW; Eriksson, N; Goel, K; Goodman, SG; James, S; Jenkins, GD; Johnson, S; Klee, EW; Morales-Rosado, JA; Pereira, NL; Rihal, CS; Roger, VL; Sicotte, H; Storey, RF; Wallentin, L; Wang, L; Weinshilboum, R; Zhang, L | 1 |
| Zimmer, V | 1 |
| Agati, LB; Bernardi, WH; Biagioni, RB; Caffaro, RA; Casella, IB; Comerota, AJ; de Freitas Soares, BL; Fidelis, RJR; Fioranelli, A; Flumignan, RLG; Joviliano, EE; Junior, VC; Lopes, RD; Ramacciotti, E; Sacilotto, R; Sobreira, ML; Van Bellen, B; Wolosker, N | 1 |
| Alsanjari, O; Hildick-Smith, D; Parker, J; Thomson, C; Trivedi, U | 1 |
| Baan, J; Brouwer, J; Buysschaert, I; Chan Pin Yin, DRPP; De Bruyne, B; Delewi, R; Dubois, CLF; Ferdinande, B; Frambach, P; Hermanides, RS; Holvoet, W; Kelder, JC; Nijenhuis, VJ; Peper, J; Rensing, BJWM; Roosen, J; Schotborgh, CE; Stella, PR; Swaans, MJ; Ten Berg, JM; Thielen, FWF; Timmers, L; Toušek, P; van 't Hof, AWJ; van der Harst, P; Van Der Heyden, JAS; van der Kley, F; van Houwelingen, GK; Veenstra, L | 1 |
| Bokemeyer, C; Fiehler, J; Frölich, AM; Haddad, M; Holst, B; Holstein, K; Janjetovic, S; Langer, F; Renné, T; Rolling, CC; Rolling, T; Tomada, J; Voigtländer, M | 1 |
| Boccuzzi, G; Brscic, E; Casu, G; Colombo, A; Golino, P; Mangieri, A; Pagnotta, PA; Pasceri, V; Patti, G; Rapacciuolo, A; Russo, V; Sticchi, A; Verolino, G; Vizzi, V | 1 |
| Angiolillo, DJ; Beitelshees, AL; Cavallari, LH; Chen, Y; Cook, KJ; Coons, JC; Dillon, C; Duarte, JD; Empey, PE; Franchi, F; Giri, J; Gong, Y; Johnson, JA; Kreutz, RP; Lee, CR; Lee, JC; Limdi, NA; McDonough, CW; Skaar, TC; Stevenson, JM; Stouffer, GA; Thomas, CD; Tuteja, S; Weck, KE | 1 |
| Kwon, O; Masic, D; Rech, MA | 1 |
| Duong, K; Eadon, MT; Fekete, K; Kenneally, A; Milway, E; Nguyen, KA; Oh, H; Schleyer, TK; Whipple, EC; Yoo, R | 1 |
| Abe, Y; Hagimoto, H; Inoue, K; Kawakita, M; Kokubun, H; Kubota, M; Makita, N; Matsuoka, T; Murata, S; Suzuki, I; Tohi, Y; Tsutsumi, N; Yamasaki, T | 1 |
| Greason, KL; Nei, SD; Scott, R; Wieruszewski, PM | 1 |
| Ahmad, B; Alraies, MC; Biswas, S; Fichman, DL; Goldsweig, AM; Pacha, HM; Prasad, A; Sattar, Y; Ullah, W; Velagapudi, P; Zaher, N; Zghouzi, M | 1 |
| Chen, Y; Wang, B; Wang, W; Wei, S | 1 |
| Altun, S; Çetinbaş, A; Okur, Mİ; Özercan, İ; Öztan, M; Yıldız Altun, A | 1 |
| Chen, W; Dang, H; Hou, H; Li, Y; Xiao, Q; Xu, X; Zhang, C; Zhao, J | 1 |
| Ben-Dor, I; Case, BC; Forrestal, BJ; Mintz, GS; Rogers, T; Satler, LF; Waksman, R; Yerasi, C | 1 |
| Cho, JY; Lee, SY; Oh, SK; Yun, KH | 1 |
| Ahn, JH; Cho, SW; Choi, JH; Choi, KH; Choi, SH; Gwon, HC; Hahn, JY; Jang, YH; Kim, DY; Lee, JM; Lee, SH; Park, KT; Park, TK; Song, YB; Yang, JH | 1 |
| Bigliardi, G; Borzì, GM; Ciolli, L; Dell'Acqua, ML; Lelli, N; Maffei, S; Meletti, S; Pentore, R; Picchetto, L; Ricceri, R; Rodríguez-Villatoro, N; Rosafio, F; Sacchetti, F; Tondelli, M; Vallone, S; Vandelli, G; Vandelli, L; Zini, A | 1 |
| Angiolillo, DJ; Capodanno, D; Cavallari, LH; Crea, F; Franchi, F; Galli, M; Rollini, F | 1 |
| Kim, KY; Lee, SH | 1 |
| Al-Ahmad, A; Anannab, A; Bassiouny, M; Burkhardt, JD; Chen, Q; Del Prete, A; Della Rocca, DG; Di Biase, L; Forleo, GB; Gallinghouse, GJ; Gianni, C; Gibson, DN; Horton, RP; Lakkireddy, D; Lavalle, C; Magnocavallo, M; Mohanty, S; Natale, A; Natale, VN; Sanchez, JE; Tarantino, N; Trivedi, C; Van Niekerk, CJ | 1 |
| Cui, JG; Huang, XH; Liu, G; Lu, J; Wu, X; Zhao, XY; Zheng, XX | 1 |
| Abdel-Wahab, M; Allali, A; El-Mawardy, M; Holy, EW; Kebernik, J; Richardt, G | 1 |
| Al-Qoofi, F; Chamandi, C; Côté, M; Dumont, E; Garcia Del Blanco, B; Généreux, P; Maluenda, G; Masson, JB; Paradis, JM; Pelletier, M; Rodés-Cabau, J; Serra, V; Thoenes, M; Webb, JG; Welsh, RC | 1 |
| Graham, BR; Menon, BK | 1 |
| Akasaka, T; Hirata, KI; Iwasaki, M; Kinutani, H; Konishi, A; Kuroda, M; Nakamura, M; Osue, T; Otake, H; Saito, S; Shinke, T; Shite, J; Takahashi, H; Takaya, T; Terashita, D; Uzu, K | 1 |
| Budaj, A; Ramotowski, B; Żuk, A | 1 |
| Anuwatworn, A; Kumar, V; Petrasko, M; Stys, A; Yee, J | 1 |
| Baschin, M; Greinacher, A; Kohlmann, T; Schroeder, HW; Selleng, S; Thiele, T; Westphal, A; Zeden, JP | 1 |
| Athanasiou, A; Damaskos, C; Moris, D; Politou, M; Spartalis, E; Spartalis, M; Tzatzaki, E | 1 |
| Fu, Q; Ma, X; You, G; Zhang, L; Zhang, X | 1 |
| Becher, PM; Blankenberg, S; Fluschnik, N; Schnabel, R; Westermann, D | 1 |
| Açıl, T; Doğan, A; Kahraman, S; Kurtoğlu, N; Özdemir, E; Saltan, Y | 1 |
| Rubboli, A | 1 |
| Aggarwal, H; Barthwal, MK; Bihan, D; Dhankani, P; Dikshit, DK; Dikshit, M; Farndale, RW; Kumar, S; Misra, A; Pandey, CP; Prakash, P; Pugh, N | 1 |
| Ahn, SG; Cho, YH; Choi, W; Garg, S; Gwon, H; Hong, MK; Hong, SJ; Jang, Y; Joo, HJ; Kang, WC; Kim, SY; Kim, W; Kim, YH; Lim, DS; Lim, YH; Park, JH; Park, JY; Shin, W; Yoon, J | 1 |
| Consolo, F; D'Angelo, A; Della Valle, P; Pappalardo, F; Pozzi, L; Sferrazza, G; Slepian, MJ | 1 |
| Chan, PH; Kwok, OH; Lam, CC; Lam, YY; Siu, CW; Wong, CK | 1 |
| Ding, L; Fang, Y; Gu, Z; Li, Y; Wang, R | 1 |
| Ardissino, D; Becker, RC; Cairns, R; Cannon, CP; Himmelmann, A; James, SK; Katus, HA; Mahaffey, KW; Storey, RF; Vignali, L; Wallentin, L | 1 |
| Fujimoto, W; Kawai, H; Miyata, T; Oishi, S; Onishi, T; Osue, T; Sawada, T; Shimane, A; Takahashi, Y; Takaya, T; Taniguchi, Y; Toba, T; Yasaka, Y | 1 |
| Gao, BL; Li, L; Li, TX; Xu, GQ; Yang, BW | 1 |
| Gach, O; Lancellotti, P; Magne, J; Nyssen, A; Oury, C; Pirlet, C | 1 |
| Al-Daher, S; Alwis, I; Calkin, AC; Chen, Y; Cohen, N; Cooper, ME; Coulter, B; Felner, EI; Jackson, SP; Ju, L; Maiocchi, S; McFadyen, JD; Schoenwaelder, SM; Tønnesen, LL; Yuan, Y; Zhu, C | 1 |
| Adams, G; Ansel, G; Baumgartner, I; Grosso, M; Jaff, M; Lin, M; Mercur, MF; Minar, E; Moll, F; Nwachuku, C; Rundback, J; Tangelder, M; Zeller, T | 1 |
| Asher, E; Beigel, R; Fefer, P; Matetzky, S; Mazin, I; Regev, E | 1 |
| Jung, JM; Kim, SU; Kwon, DY; Park, JW; Park, MH | 1 |
| Hirata, KI; Kijima, Y; Kozuki, A; Masano, T; Nagoshi, R; Otake, H; Shibata, H; Shinke, T; Shite, J; Takeshige, R; Tsukiyama, Y; Yanaka, KI | 1 |
| Chen, Y; Dong, P; Duan, Y; Gao, X; Han, J; Li, Q; Li, X; Qian, K; Wang, Y; Wei, Z; Yang, X; Zhang, S; Zhao, B; Zhao, D; Zhu, Y | 1 |
| Gibler, WB | 1 |
| Fredgart, M; Gill, S | 1 |
| Guo, S; Li, W; Li, Z; Pan, W; Sun, X; Sun, Y; Wang, L; Wang, S | 1 |
| Brunner, S; Hamm, W; Lackermair, K; Mehr, M; Rizas, K | 1 |
| Huang, F | 1 |
| Huang, J; Liu, L; Tang, X; Zhang, X | 1 |
| Antonicelli, R; Cecchini, S; Di Pillo, R; Galeazzi, R; Giovagnetti, S; Malatesta, G; Montesanto, A; Olivieri, F; Rose, G; Spazzafumo, L | 1 |
| Beck, DE; Green, HM; Hicks, TC; Hite, N; Klinger, AL; Margolin, DA; Miller, P; Whitlow, CB | 1 |
| Carlsen, SM; Giannadakis, C; Gulati, AM; Gulati, S; Jakola, AS; Jensberg, H; Madsbu, MA; Salvesen, Ø; Solheim, O; Øie, LR | 1 |
| Fong, AYY; Koh, KT; Ong, TK; Tan, SSN; Tiong, LL | 1 |
| Alshbool, FZ; Du, C; Geng, B; Karim, ZA; Khasawneh, FT; Liu, C; Ren, X; Romero, EL; Sanca, AJ; Zhong, D; Zhou, J; Zhu, Y | 1 |
| Colivicchi, F; Falaschi, G; Tubaro, M | 1 |
| Chen, M; Hu, X; Wang, Y; Yang, FY; Zhang, Y | 1 |
| Garcia-Garcia, HM; Shlofmitz, E | 1 |
| Chang, TY; Fan, PY; Hsieh, MY; Kuo, CF; Lee, CC; Li, IJ; Liu, SH; Tian, YC; Tu, KH; Weng, CH; Wu, HH; Yang, CW | 1 |
| Farag, M; Gorog, DA; Gue, YX; Spinthakis, N; Srinivasan, M; Wellsted, DM | 1 |
| Chan, FKL; Cheong, PK; Ching, JYL; Hsiang, JC; Kee, KM; Kyaw, MH; Lam, K; Lee, V; Lo, A; Ng, D; Ng, SC; Suen, BY; Tse, YK | 1 |
| Duconge, J; Gonzalez, S; Hernandez-Suarez, DF; Hua, S; Kaplan, RC; Melin, K; Moon, JY; Qi, Q; Zeng, D | 1 |
| Deveja, R; Hoxha, A; Qirjazi, T; Shehu, S | 1 |
| Du, L; Du, X; Lai, J; Lai, Q; Tu, B; Wan, Z; Xu, B; Zhang, F; Zhao, M; Zhou, Y | 1 |
| Cavender, MA; Kim, SM | 1 |
| Amano, Y; Harada, H; Hayasaka, K; Katsuyama, Y; Murakami, D; Nagasaka, T; Nakahara, R; Sagami, R; Suehiro, S; Ujihara, T | 1 |
| Barra, ME; Berger, K; Brophy, GM; Tesoro, EP | 1 |
| Aradi, D; Filipiak, KJ; Gori, T; Gross, L; Hadamitzky, M; Huber, K; Huczek, Z; Jacobshagen, C; Klopotowski, M; Koltowski, L; Komosa, A; Kowara, M; Lesiak, M; Massberg, S; Opolski, G; Parma, R; Rymuza, B; Sibbing, D; Tomaniak, M; Witkowski, A | 1 |
| Albertsson, P; Angerås, O; Dworeck, C; Erlinge, D; Haraldsson, I; Ioanes, D; Koul, S; Odenstedt, J; Omerovic, E; Persson, J; Petursson, P; Råmunddal, T; Redfors, B; Völz, S | 1 |
| Altındağ, R; Altıntaş, B; Baysal, E; Bilge, Ö; Burak, C; Ede, H; Karahan, MZ; Öztürk, Ö; Tanboğa, İH; Yaylak, B | 1 |
| Anisimova, VA; Divaeva, LN; Kucheryavenko, AF; Kuz'menko, TA; Morkovnik, AS; Sirotenko, VS; Spasov, AA | 1 |
| Fox, KAA; Gurbel, PA; Tantry, US; Ten Cate, H; Weitz, JI | 1 |
| Brust, K; Garncarek, M; Jagas, J; Roleder, T; Witkiewicz, W | 1 |
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| Dropinski, J; Jakiela, B; Musial, J; Sanak, M; Szczeklik, A; Wegrzyn, W | 1 |
| Leschke, M; Sauer, H | 1 |
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| Bui, A; Chu, WW; Clavijo, LC; Fournadjieva, J; Gevorkian, N; Kent, KM; Kim, SW; Kuchulakanti, PK; Ohlmann, P; Pichard, AD; Rha, SW; Satler, LF; Smith, K; Suddath, WO; Torguson, R; Waksman, R; Xue, Z | 1 |
| Alfonso, F; Angiolillo, DJ; Bañuelos, C; Bass, TA; Bernardo, E; Costa, MA; Escaned, J; Fernandez-Ortiz, A; Hernández, R; Jimenez-Quevedo, P; Macaya, C; Moreno, R; Ramírez, C; Sabaté, M | 1 |
| Alexandridou, S; Betsis, D; Blouhos, K; Megalopoulos, A; Tsachalis, T; Tsalis, K; Vasiliadis, K | 1 |
| Badimon, JJ; Bylock, A; Elg, M; Eriksson, UG; Eriksson-Lepkowska, M; Kalies, I; Nyström, P; Sarich, TC; Wåhlander, K | 1 |
| Berger, PB; Bhatt, DL; Black, HR; Boden, WE; Booth, J; Brennan, DM; Cacoub, P; Cohen, EA; Creager, MA; Easton, JD; Fabry-Ribaudo, L; Flather, MD; Fox, KA; Hacke, W; Haffner, SM; Hamm, CW; Hankey, GJ; Johnston, SC; Mak, KH; Mas, JL; Montalescot, G; Pearson, TA; Steg, PG; Steinhubl, SR; Topol, EJ; Weber, MA | 1 |
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| Hoffmann, R; Kaiser, A; Radke, PW; Schunkert, H; Weber, C; Zernecke, A | 1 |
| Batisse, A; Batisse, JP; Beygui, F; Choussat, R; Collet, JP; Helft, G; Le Feuvre, C; Metzger, JP; Montalescot, G | 1 |
| de Boer, MJ; Hautvast, RW; Heestermans, AA; Jaarsma, W; ten Berg, JM; van Werkum, JW | 1 |
| Armstrong, PW; Buller, CE; Gallo, R; O'Neill, BJ; Pate, GE; Webb, JG; Welsh, RC | 1 |
| Holzhausen, C; Ince, H; Körber, T; Nienaber, CA; Rehders, T; Schneider, H; Weber, F | 1 |
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| Altamura, L; Crea, F; De Vita, M; Ferrante, G; Fusco, B; Leone, AM; Niccoli, G; Rebuzzi, AG; Siviglia, M | 1 |
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| Carberry, KE; Chang, AC; Dreyer, WJ; Kennedy, CE; McKenzie, ED; Moffett, BS; Morales, DL; Price, JF; Studer, MA; Teitel, ER | 1 |
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| Abbate, R; Antonucci, E; Gensini, GF; Giglioli, C; Gori, AM; Mannini, L; Marcucci, R; Paniccia, R; Prisco, D; Valente, S | 1 |
| Borgdorff, P; Paulus, WJ; Tangelder, GJ | 1 |
| Bünger, CM; Grabow, N; Hauenstein, K; Ince, H; Ketner, L; Klar, E; Kreutzer, HJ; Kröger, C; Lootz, D; Lorenzen, B; Nienaber, CA; Schareck, W; Schmitz, KP; Sternberg, K | 1 |
| Brittenden, J; Collins, P; Ford, I; Greaves, M; Macaulay, E | 1 |
| Kastrati, A; Schömig, A; Sibbing, D; von Beckerath, N; von Beckerath, O | 1 |
| Agarwala, RA; Curzen, NP; Dawkins, KD; Swallow, RA | 1 |
| Antman, EM; Braunwald, E; Gibson, CM; McCabe, CH; Montalescot, G; Riesmeyer, J; Warmke, JW; Weerakkody, G; Winters, KJ; Wiviott, SD | 1 |
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| Alviar, CL; Arikan, ME; Dave, BP; DeLao, T; Granada, JF; Kleiman, NS; Lev, EI; Maresh, K; Tellez, A | 1 |
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| Aichner, FT; Nussbaumer, K; Topakian, R; Trenkler, J | 1 |
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| Graf, I; Kastrati, A; Pogatsa-Murray, G; Schömig, A; Sibbing, D; von Beckerath, N; Wieczorek, A | 1 |
| Crain, EJ; Knabb, RM; Lam, PY; Quan, ML; Watson, CA; Wexler, RR; Wong, PC | 1 |
| Lyseng-Williamson, KA; Plosker, GL | 1 |
| Badimon, L; Padró, T; Pena, E; Vilahur, G | 1 |
| Huber, K; Kozek-Langenecker, S; Metzler, H; Münch, A; Vicenzi, MN | 1 |
| Aleil, B; Cazenave, JP; Gachet, C; Monassier, JP; Rochoux, G | 1 |
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| Fitzgerald, DJ; Maree, AO | 1 |
| Alessi, MC; Bali, L; Bonnet, JL; Cuisset, T; Frere, C; Quilici, J; Saidi, LN | 1 |
| Alexander, S; Bryant, J; Buckman, BO; da Cunha, V; Dole, WP; Fitch, RM; Islam, I; Mallari, C; Martin-McNulty, B; Morser, J; Post, JM; Subramanyam, B; Sullivan, ME; Vergona, R; Vincelette, J; Wang, YX; Yuan, S | 1 |
| Bhatt, DL; Meadows, TA | 1 |
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| Abbate, R; Antoniucci, D; Buonamici, P; Gensini, GF; Gori, AM; Marcucci, R; Migliorini, A; Moschi, G; Paniccia, R; Santini, A | 1 |
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| Aydinalp, A; Ertan, C; Gulmez, O; Kaynar, G; Konas, D; Muderrisoglu, H; Ozin, B; Yildirir, A | 1 |
| Badimon, JJ; Bhatt, DL; Herbert, JM; Lüscher, TF; Steinhubl, SR | 1 |
| Goodall, AH; Hayes, PD; Jones, CI; Naylor, AR; Payne, DA | 1 |
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| van der Linden, J | 1 |
| Eder, C; Funke, U; Lutze, G; Prasse, T; Schulze, M; Töpfer, G; Zimmermann, M | 1 |
| Chelliah, R; Fox, KA | 1 |
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| Bocksch, W; Boxberger, M; Degenhardt, R; Gross, M; Horstkotte, D; Nienaber, C; Schneider, H; Unverdorben, M; Vallbracht, C; Wiemer, M | 1 |
| Bystron, M; Cervinka, P; Jakabcin, J; Kala, P; Kvasnak, M; Malý, J; Spacek, R; Veselka, J | 1 |
| Badimon, L; Casaní, L; Vilahur, G | 1 |
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| Bareiss, P; Desprez, D; Faure, A; Grunebaum, L; Jesel, L; Morel, O; Ohlmann, P | 1 |
| de Korte, FI; Ten Berg, JM; van Werkum, JW; Vijverberg, PL | 1 |
| Lip, GY | 1 |
| Antman, EM; Ardissino, D; Braunwald, E; De Servi, S; Gibson, CM; Gottlieb, S; McCabe, CH; Montalescot, G; Murphy, SA; Neumann, FJ; Riesmeyer, J; Ruzyllo, W; Weerakkody, G; Wiviott, SD | 1 |
| Asai, F; Hashimoto, M; Isobe, T; Jakubowski, JA; Niitsu, Y; Ogawa, T; Otsuguro, K; Sugidachi, A | 1 |
| Blindt, R; de Taeye, A; Hoffmann, R; Kelm, M; Kiefer, P; Müller, R; Stellbrink, K; Weber, C; Yagmur, E | 1 |
| Dawley, CA; Fletcher, SF; Walker, CW | 1 |
| Salzman, BE; Simmons, BB | 1 |
| Amit, G; Leibowitz, D; Rott, D; Weiss, AT; Zahger, D | 1 |
| Alfonso, F; Angiolillo, DJ; Bass, TA; Bernardo, E; Desai, B; Fernandez-Ortiz, A; Guzman, LA; Hernández-Antolin, R; Macaya, C; Palazuelos, J; Weisberg, I; Zenni, MZ | 1 |
| Koellnberger, M; Konrad, I; Lorenz, R; Massberg, S; Orschiedt, L; Sauer, S; Schulz, C; Walter, U | 1 |
| Bareiss, P; Morel, O; Ohlmann, P | 1 |
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| Bareiss, P; Bernhard, N; Desprez, D; Freyssinet, JM; Grunebaum, L; Morel, O; Toti, F | 1 |
| Di Gennaro, L; Landolfi, R | 1 |
| Assali, A; Battler, A; Brosh, D; Fuchs, S; Kornowski, R; Lev, EI; Vaknin-Assa, H | 1 |
| Gawaz, M; Geisler, T; May, AE | 1 |
| Hackeng, CM; Kelder, JC; Postma, S; ten Berg, JM; Topcu, Y; van Werkum, JW; Verheugt, FW | 1 |
| Ellahham, S | 1 |
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| Antman, EM; Braunwald, E; Downey, WE; Herrman, JP; Horvath, I; Keltai, M; McCabe, CH; Murphy, SA; Scirica, BM; Van de Werf, F; Wiviott, SD | 1 |
| Baxi, S; Karnicki, K; Leadley, RJ; McBane, RD; Peterson, T; Wysokinski, W | 1 |
| Kapoor, JR | 1 |
| Billett, HH | 1 |
| Ezekowitz, M; Lee, R; Nagarakanti, R; Sodhi, S | 1 |
| Brodie, BR | 1 |
| De Servi, S; Lettino, M | 1 |
| Bordes, P; Gómez, S; Mainar, V; Pineda, J; Sogorb, F; Valencia, J | 1 |
| Ajani, AE; Lefkovits, J | 1 |
| Kastrati, A; Schömig, A; Sibbing, D; Taubert, D; Von Beckerath, N | 1 |
| Allon, M; Beck, GJ; Braden, GL; Davidson, IJ; Delmez, JA; Dember, LM; Dixon, BS; Feldman, HI; Gassman, JJ; Greenberg, A; Greene, T; Himmelfarb, J; Ikizler, TA; Kaufman, JS; Kusek, JW; Meyers, CM; Radeva, MK; Rocco, MV; Vazquez, MA | 1 |
| Angiolillo, D; Bates, E; Berger, PB; Bhatt, D; Braunwald, E; Cannon, CP; Furman, MI; Gurbel, P; Michelson, AD; Peterson, E; Wiviott, S | 2 |
| Cassetti, E; De Luca, G; Marino, P | 1 |
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| Bernat, A; Herbert, JM; Maffrand, JP | 1 |
| Verstraete, M; Zoldhelyi, P | 1 |
| Hirata, Y; Nakashima, M; Uematsu, T; Umemura, K | 1 |
| Barstad, RM; Dickinson, JP; Kieffer, G; Kierulf, P; Roald, HE; Sakariassen, KS; Skjørten, F | 1 |
| Aït-Chek, L; Bernat, A; Dumas, A; Herbert, JM; Savi, P | 1 |
| Bernat, A; Dol, F; Herbert, JM; Rinaldi, M; Sainte-Marie, M | 1 |
| Nurden, AT | 1 |
| Keil, Tu | 1 |
| Hankey, GJ | 1 |
| Bernat, A; Herbert, JM; Hoffmann, P; Savi, P | 1 |
| Schneider, D | 1 |
| Bernat, A; Dol, F; Falotico, R; Herbert, JM; Lalé, A; Savi, P | 1 |
| Chronos, NR; Hanson, SR; Harker, LA; Herbert, JM; Kelly, AB; Marzec, UM; Sundell, IB | 1 |
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| Asai, F; Inoue, T; Koike, H; Ogawa, T; Sugidachi, A | 1 |
| Diot, E; Gruel, Y; Guilmot, JL | 1 |
| Boneu, B; Bossavy, JP; Cadroy, Y; Sagnard, L; Sakariassen, K; Thalamas, C | 1 |
| Curran, SC; Herrmann, HC; Hirshfeld, JW; Klugherz, BD; Kolansky, DM; Magness, K; Wilensky, RL | 1 |
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| Fiore, L; Hasbargen, JA; Kaufman, JS; O'Connor, TZ; Perdriset, G | 1 |
| Abizaid, AS; Curry, BH; Dangas, G; Kent, KM; Lansky, AJ; Leon, MB; Mehran, R; Paliou, M; Pichard, AD; Satler, LF; Stone, GW | 1 |
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| Ajani, AE; Bui, AB; Dieble, R; Gruberg, L; Kent, KK; Lindsay, J; Mintz, GS; Pichard, AD; Pinnow, E; Satler, LF; Taaffe, M; Waksman, R; White, RL | 1 |
| Davis, CJ; Lowry, DR; McKenzie, ME; Nair, GV; Serebruany, VL | 1 |
| Dewit, LG; Stewart, FA; te Poele, JA; van der Wal, AF; van Kleef, EM | 1 |
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| Bailliart, O; Bonneau, M; Bonnin, P; Caen, JP; Drouet, LO; Maffrand, JP; Mazoyer, E; Pignaud, G; Samama, CM; Viars, P | 1 |
| Maruyama, S; Uchiyama, S; Yamazaki, M | 1 |
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227 review(s) available for clopidogrel and Thrombosis
| Article | Year |
|---|---|
Prevalence and clinical impact of high platelet reactivity in patients with chronic kidney disease treated with percutaneous coronary intervention: An updated systematic review and meta-analysis.
Topics: Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prevalence; Renal Insufficiency, Chronic; Risk Factors; Thrombosis; Treatment Outcome | 2022 |
Comparison of Ticagrelor With Clopidogrel in East Asian Patients With Acute Coronary Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Topics: Acute Coronary Syndrome; Asian People; Clopidogrel; Dyspnea; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Thrombosis; Ticagrelor; Treatment Outcome | 2022 |
Efficacy and Safety of Clopidogrel Versus Ticagrelor as Part of Dual Antiplatelet Therapy in Acute Coronary Syndrome-A Systematic Review and Meta-analysis.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Dyspnea; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Ticagrelor; Treatment Outcome | 2022 |
A Review of the Role of the Antiplatelet Drug Ticagrelor in the Management of Acute Coronary Syndrome, Acute Thrombotic Disease, and Other Diseases.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Thrombosis; Ticagrelor | 2022 |
Newer P2Y
Topics: Clopidogrel; Female; Heart Arrest; Hemorrhage; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Shock, Cardiogenic; Thrombosis; Treatment Outcome | 2022 |
Pleiotropic effects of clopidogrel.
Topics: Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombosis; Treatment Outcome | 2022 |
Antiplatelet agents and anticoagulants for hypertension.
Topics: Aged; Anticoagulants; Aspirin; Clopidogrel; Fibrinolytic Agents; Hemorrhage; Humans; Hypertension; Middle Aged; Platelet Aggregation Inhibitors; Thromboembolism; Thrombosis; Warfarin | 2022 |
Antagonizing P2Y12 Receptor Inhibitors: Current and Future Options.
Topics: Administration, Oral; Antibodies, Monoclonal; Blood Platelets; Broadly Neutralizing Antibodies; Cardiology; Clopidogrel; Hemadsorption; Hemorrhage; Hemostasis; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk; Signal Transduction; Thrombosis; Ticagrelor | 2019 |
Triple versus double antithrombotic therapy in patients with atrial fibrillation and stent implantation: a meta‑analysis of randomized trials.
Topics: Aged; Aged, 80 and over; Anticoagulants; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Randomized Controlled Trials as Topic; Stents; Thrombosis; Treatment Outcome | 2019 |
Antiplatelet therapies in diabetes.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Diabetes Mellitus; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Primary Prevention; Secondary Prevention; Thrombosis; Ticagrelor | 2020 |
Risk Factors for Bleeding and Clinical Ineffectiveness Associated With Clopidogrel Therapy: A Comprehensive Meta-Analysis.
Topics: Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Dual Anti-Platelet Therapy; Hemorrhage; Humans; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Thrombosis; Time Factors; Treatment Failure | 2021 |
Meta-Analysis Comparing the Safety and Efficacy of Single vs Dual Antiplatelet Therapy in Post Transcatheter Aortic Valve Implantation Patients.
Topics: Aortic Valve Stenosis; Aspirin; Clopidogrel; Dual Anti-Platelet Therapy; Hemorrhage; Humans; Ischemic Attack, Transient; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Postoperative Care; Stroke; Thrombosis; Transcatheter Aortic Valve Replacement | 2021 |
Effects of clopidogrel, prasugrel and ticagrelor on prevention of stent thrombosis in patients underwent percutaneous coronary intervention: A network meta-analysis.
Topics: Clopidogrel; Humans; Network Meta-Analysis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thrombosis; Ticagrelor | 2021 |
Usefulness of Antiplatelet Therapy After Transcatheter Aortic Valve Implantation.
Topics: Aortic Valve Stenosis; Aspirin; Cause of Death; Clopidogrel; Dual Anti-Platelet Therapy; Endothelium; Evidence-Based Medicine; Hemorrhage; Humans; Mortality; Platelet Aggregation Inhibitors; Stroke; Thrombosis; Transcatheter Aortic Valve Replacement | 2021 |
Genetic testing in patients undergoing percutaneous coronary intervention: rationale, evidence and practical recommendations.
Topics: Clopidogrel; Genetic Testing; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Precision Medicine; Purinergic P2Y Receptor Antagonists; Thrombosis | 2021 |
A Primer on Bleeding Risk and Management Strategies of Newer Oral Anti Platelet Agents in Cardiovascular Disease.
Topics: Adenosine; Administration, Oral; Aspirin; Cardiovascular Diseases; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Factors; Thrombosis; Ticagrelor; Ticlopidine | 2016 |
The role of prasugrel in the management of acute coronary syndromes: a systematic review.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thrombosis; Ticlopidine | 2017 |
Advances in the Treatment of Stable Coronary Artery Disease and Peripheral Artery Disease.
Topics: Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Disease; DNA; Drug Therapy, Combination; Factor Xa; Factor Xa Inhibitors; Fibrinolytic Agents; Hemorrhage; Histones; Humans; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Rivaroxaban; Thrombosis; Warfarin | 2018 |
Stent thrombosis associated with drug eluting stents on addition of cilostazol to the standard dual antiplatelet therapy following percutaneous coronary intervention: a systematic review and meta-analysis of published randomized controlled trials.
Topics: Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis | 2018 |
Efficacy and safety of triple therapy versus dual antiplatelet therapy in patients with atrial fibrillation undergoing coronary stenting: A meta-analysis.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Female; Fibrinolytic Agents; Hemorrhage; Humans; Hypertension; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Stents; Stroke; Thrombosis; Warfarin | 2018 |
[Antithrombotic therapy in patients with atrial fibrillation and acute coronary syndrome].
Topics: Acute Coronary Syndrome; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Thrombosis | 2018 |
Single versus Dual Antiplatelet Therapy after Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-Analysis.
Topics: Aortic Valve; Aspirin; Cerebrovascular Disorders; Clopidogrel; Drug Therapy, Combination; Heart Valve Prosthesis; Hemorrhage; Humans; Mortality; Platelet Aggregation Inhibitors; Risk Assessment; Thrombosis; Treatment Outcome | 2018 |
Periprocedural Neuroendovascular Antiplatelet Strategies for Thrombosis Prevention in Clopidogrel-Hyporesponsive Patients.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Endovascular Procedures; Humans; Intracranial Aneurysm; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Thrombosis; Treatment Outcome | 2019 |
Combination Antiplatelet and Oral Anticoagulant Therapy in Patients With Coronary and Peripheral Artery Disease.
Topics: Administration, Oral; Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Disease; Humans; Percutaneous Coronary Intervention; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Thrombosis | 2019 |
Genotype-guided antiplatelet therapy compared with conventional therapy for patients with acute coronary syndromes: a systematic review and meta-analysis.
Topics: Acute Coronary Syndrome; Aspirin; Blood Platelets; Cerebral Revascularization; Clopidogrel; Cytochrome P-450 CYP2C19; Gene Expression; Genotype; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stroke; Survival Analysis; Thrombosis | 2019 |
Duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stent: systematic review and network meta-analysis.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug-Eluting Stents; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis | 2019 |
Acute Carotid Stent Thrombosis in an Ultrarapid Clopidogrel Metabolizer: Case Report and Literature Review.
Topics: Acute Disease; Administration, Intravenous; Angiography, Digital Subtraction; Angioplasty, Balloon; Carotid Stenosis; Clopidogrel; Computed Tomography Angiography; Cytochrome P-450 CYP2C19; Drug Substitution; Eptifibatide; Genotype; Humans; Male; Middle Aged; Pharmacogenomic Variants; Phenotype; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombectomy; Thrombosis; Ticagrelor; Treatment Outcome | 2019 |
Dual antiplatelet therapy with aspirin and clopidogrel: what is the risk in noncardiac surgery? A narrative review.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; PubMed; Risk Assessment; Stents; Surgical Procedures, Operative; Thrombosis; Ticlopidine | 2013 |
Monitoring aspirin and clopidogrel response: testing controversies and recommendations.
Topics: Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Precision Medicine; Stents; Thrombosis; Ticlopidine | 2013 |
Pharmacogenomics of anti-platelet and anti-coagulation therapy.
Topics: Anticoagulants; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Outcome; Warfarin | 2013 |
Late and very late stent thrombosis in patients with second-generation drug-eluting stents.
Topics: Aspirin; Cardiotonic Agents; Clopidogrel; Drug-Eluting Stents; Everolimus; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Design; Sirolimus; Thrombosis; Ticlopidine; Time Factors | 2013 |
Focused 2012 update of the Canadian Cardiovascular Society guidelines for the use of antiplatelet therapy.
Topics: Acute Coronary Syndrome; Adenosine; Anticoagulants; Aspirin; Clinical Trials as Topic; Clopidogrel; Contraindications; Coronary Artery Bypass; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proton Pump Inhibitors; Secondary Prevention; Stents; Stroke; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2013 |
Cangrelor versus clopidogrel in percutaneous coronary intervention: a systematic review and meta-analysis.
Topics: Adenosine Monophosphate; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine | 2014 |
What's new about clopidogrel.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Stents; Thrombosis; Ticlopidine; Treatment Failure | 2013 |
Unanswered questions in patients with concurrent atrial fibrillation and acute coronary syndrome.
Topics: Acute Coronary Syndrome; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Comorbidity; Drug Therapy, Combination; Factor Xa Inhibitors; Humans; Morpholines; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Pyrazoles; Pyridones; Risk Assessment; Rivaroxaban; Stroke; Thiophenes; Thrombosis; Ticlopidine | 2014 |
[Use of antiplatelet agents in patients with chronic kidney disease: what is the evidence?].
Topics: Adenosine; Blood Platelet Disorders; Clopidogrel; Evidence-Based Practice; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Renal Insufficiency, Chronic; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2014 |
Efficacy and safety of cilostazol based triple antiplatelet treatment versus dual antiplatelet treatment in patients undergoing coronary stent implantation: an updated meta-analysis of the randomized controlled trials.
Topics: Aspirin; Brain Ischemia; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Stroke; Tetrazoles; Thrombosis; Ticlopidine | 2015 |
Systematic reviews and meta-analyses for more profitable strategies in peripheral artery disease.
Topics: Adenosine; Aspirin; Asymptomatic Diseases; Cilostazol; Clopidogrel; Fibrinolytic Agents; Humans; Intermittent Claudication; Ischemia; Lower Extremity; Meta-Analysis as Topic; Myocardial Infarction; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Primary Prevention; Review Literature as Topic; Secondary Prevention; Stroke; Tetrazoles; Thrombosis; Ticagrelor; Ticlopidine | 2014 |
CYP2C19 genotype has a greater effect on adverse cardiovascular outcomes following percutaneous coronary intervention and in Asian populations treated with clopidogrel: a meta-analysis.
Topics: Alleles; Asian People; Clopidogrel; Coronary Occlusion; Cytochrome P-450 CYP2C19; Databases, Factual; Genotype; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Risk; Stents; Thrombosis; Ticlopidine | 2014 |
Resistance to antiplatelet drugs: what progress has been made?
Topics: Aspirin; Clopidogrel; Graft Occlusion, Vascular; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Precision Medicine; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Failure | 2014 |
[Added value of clopidogrel in cardiology and neurology].
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Stroke; Thrombosis; Ticlopidine | 2014 |
Effect of high-dose clopidogrel according to CYP2C19*2 genotype in patients undergoing percutaneous coronary intervention- a systematic review and meta-analysis.
Topics: Alleles; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine | 2015 |
Novel oral P2Y12 inhibitor prasugrel vs. clopidogrel in patients with acute coronary syndrome: evidence based on 6 studies.
Topics: Acute Coronary Syndrome; Administration, Oral; Clopidogrel; Evidence-Based Medicine; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Risk Factors; Stroke; Thrombosis; Ticlopidine | 2015 |
Bleeding and stent thrombosis on P2Y12-inhibitors: collaborative analysis on the role of platelet reactivity for risk stratification after percutaneous coronary intervention.
Topics: Aged; Clopidogrel; Female; Graft Occlusion, Vascular; Hemorrhage; Humans; Male; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Assessment; Stents; Thrombosis; Ticlopidine | 2015 |
Switching from Clopidogrel to Prasugrel in patients undergoing PCI: A meta-analytic overview.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Substitution; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome | 2016 |
New-onset atrial fibrillation after recent coronary stenting: Warfarin or non-vitamin K-antagonist oral anticoagulants to be added to aspirin and clopidogrel? A viewpoint.
Topics: Anticoagulants; Antithrombins; Aspirin; Atrial Fibrillation; Clopidogrel; Dabigatran; Drug Combinations; Factor Xa Inhibitors; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Pyrazoles; Pyridones; Stents; Thrombosis; Ticlopidine; Warfarin | 2015 |
Vorapaxar for reduction of thrombotic cardiovascular events in myocardial infarction and peripheral artery disease.
Topics: Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Half-Life; Hemorrhage; Humans; Lactones; Myocardial Infarction; Myocardial Ischemia; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Receptor, PAR-1; Secondary Prevention; Stroke; Thrombosis; Ticlopidine | 2015 |
Comparing the effectiveness and safety between triple antiplatelet therapy and dual antiplatelet therapy in type 2 diabetes mellitus patients after coronary stents implantation: a systematic review and meta-analysis of randomized controlled trials.
Topics: Acute Coronary Syndrome; Aspirin; Cilostazol; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Stents; Tetrazoles; Thrombosis; Ticlopidine | 2015 |
On-treatment platelet reactivity: State of the art and perspectives.
Topics: Acute Coronary Syndrome; Adenosine; Age Factors; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Hemorrhage; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Sex Factors; Stents; Thrombosis; Ticagrelor; Ticlopidine | 2016 |
Clopidogrel Response Variability: Review of the Literature and Practical Considerations.
Topics: Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine; Treatment Failure | 2016 |
The pharmacodynamics of antiplatelet compounds in thrombosis treatment.
Topics: Acute Coronary Syndrome; Animals; Aspirin; Blood Platelets; Clopidogrel; Drug Design; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Thrombosis; Ticlopidine | 2016 |
What is the optimal duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stent implantation?
Topics: Aspirin; Clopidogrel; Drug Administration Schedule; Drug-Eluting Stents; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine; Time Factors | 2016 |
Management of Antiplatelet Allergy After Cardiac Stenting.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug Administration Schedule; Drug Eruptions; Drug-Eluting Stents; Female; Humans; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prednisone; Stents; Thrombosis; Ticlopidine | 2016 |
Cangrelor for the management and prevention of arterial thrombosis.
Topics: Adenosine Monophosphate; Administration, Intravenous; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Thrombosis; Ticlopidine | 2016 |
Prasugrel hydrochloride for the treatment of acute coronary syndrome patients.
Topics: Acute Coronary Syndrome; Administration, Oral; Aspirin; Blood Platelets; Clopidogrel; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thrombosis; Ticlopidine | 2016 |
Current controversies in the use of aspirin and ticagrelor for the treatment of thrombotic events.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Thrombosis; Ticagrelor; Ticlopidine | 2016 |
Genetic Determinants of P2Y
Topics: Acute Coronary Syndrome; Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Percutaneous Coronary Intervention; Polymorphism, Single Nucleotide; Purinergic P2Y Receptor Antagonists; Thrombosis; Ticlopidine | 2017 |
Potential Usefulness of Clopidogrel Pharmacogenetics in Cerebral Endovascular Procedures and Carotid Artery Stenting.
Topics: Carotid Artery Diseases; Cerebrovascular Disorders; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance, Neoplasm; Endovascular Procedures; Humans; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2017 |
Monitoring Antiplatelet Therapy.
Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Monitoring; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Reproducibility of Results; Thrombosis; Ticlopidine | 2017 |
[Clopidogrel--clinical use and potential therapeutic problems].
Topics: Angioplasty, Balloon, Coronary; Blood Vessel Prosthesis; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart Diseases; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Stents; Thrombosis; Ticlopidine | 2008 |
Clopidogrel and coronary stents: risks and benefits.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Vessels; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2008 |
Antithrombotic therapy in patients treated with oral anticoagulation undergoing coronary artery stenting. An expert consensus document with focus on atrial fibrillation.
Topics: Administration, Oral; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Revascularization; Postoperative Care; Stents; Thrombosis; Ticlopidine; Warfarin | 2008 |
Treatment strategies in non-ST-elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention: an evidence-based review of clinical trial results and treatment guidelines: report on a roundtable discussion.
Topics: Acute Coronary Syndrome; Algorithms; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Cardiovascular Agents; Clinical Trials as Topic; Clopidogrel; Emergency Treatment; Evidence-Based Medicine; Fibrinolytic Agents; Hirudins; Humans; Peptide Fragments; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Hemorrhage; Practice Guidelines as Topic; Prasugrel Hydrochloride; Recombinant Proteins; Risk Assessment; Stents; Thiophenes; Thrombosis; Ticlopidine | 2008 |
Clinical implications of aspirin resistance.
Topics: Aspirin; Atherosclerosis; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Drug Resistance; Humans; Ischemia; Research Design; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Reducing the risk of adverse thrombotic events - The role of aspirin and clopidogrel.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2008 |
Antiplatelet drugs in cardiological practice: established strategies and new developments.
Topics: Atherosclerosis; Clopidogrel; Drug-Eluting Stents; Humans; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Pyridines; Receptors, Thromboxane; Signal Transduction; Thiophenes; Thrombosis; Ticlopidine | 2008 |
Drug-eluting stents and antiplatelet resistance.
Topics: Aspirin; Clopidogrel; Drug Resistance; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2008 |
Intensity of antiplatelet therapy in patients with acute coronary syndromes and percutaneous coronary intervention: the promise of prasugrel?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine | 2008 |
The genetics of antiplatelet drug resistance.
Topics: Aspirin; Blood Platelets; Clopidogrel; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thrombosis; Ticlopidine | 2009 |
Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Working
Topics: Aspirin; Clopidogrel; Coronary Disease; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2009 |
Antiplatelet therapy after endovascular intervention: does combination therapy really work and what is the optimum duration of therapy?
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Vessel Prosthesis Implantation; Cardiovascular Diseases; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Evidence-Based Medicine; Graft Occlusion, Vascular; Humans; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency | 2009 |
Combination antiplatelet therapy in patients with peripheral arterial disease: is the best therapy aspirin, clopidogrel, or both?
Topics: Aspirin; Atherosclerosis; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Evidence-Based Medicine; Hemodynamics; Hemorrhage; Humans; Ischemia; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Risk Assessment; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Significant gastrointestinal bleeding in patients at risk of coronary stent thrombosis.
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Anti-Bacterial Agents; Aspirin; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Helicobacter Infections; Helicobacter pylori; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Review of prasugrel for the secondary prevention of atherothrombosis.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Atherosclerosis; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Risk Factors; Thiophenes; Thrombosis; Ticlopidine | 2009 |
Diabetes and acute coronary syndromes.
Topics: Acute Coronary Syndrome; Anticoagulants; Aspirin; Blood Glucose; Clopidogrel; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Enoxaparin; Hirudins; Humans; Hypoglycemic Agents; Peptide Fragments; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Recombinant Proteins; Thiophenes; Thrombosis; Ticlopidine | 2009 |
Aspirin and clopidogrel: efficacy and resistance in diabetes mellitus.
Topics: Aspirin; Clopidogrel; Diabetes Mellitus; Drug Resistance; Endothelium, Vascular; Humans; Ischemia; Oxidative Stress; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2009 |
Clopidogrel response variability: current status and future directions.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2009 |
[Prodrug activation as a crucial difference. Prasugrel - a new ADP receptor antagonist].
Topics: Animals; Biotransformation; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Assessment; Thiophenes; Thrombosis; Ticlopidine | 2009 |
[Diagnosis, causes, relevance of a complex phenomenon. Resistance to aspirin and clopidogrel].
Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Interactions; Drug Resistance; Humans; Phosphorylation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Thromboxanes; Ticlopidine | 2009 |
[A current problem for regulators. Clopidogrel and pharmacokinetics].
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Industry; Drug Interactions; Drug Therapy, Combination; Enzyme Induction; Enzyme Inhibitors; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thrombosis; Ticlopidine; United States; United States Food and Drug Administration | 2009 |
Improving adjunctive pharmacotherapy for primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: beyond the HORIZONS-AMI trial.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Chemotherapy, Adjuvant; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Heparin; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Recombinant Proteins; Risk Assessment; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Antiplatelet therapy discontinuation following drug-eluting stent placement: dangers, reasons, and management recommendations.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Health Knowledge, Attitudes, Practice; Hemorrhage; Humans; Medication Adherence; Oral Surgical Procedures; Patient Education as Topic; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Practice Guidelines as Topic; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Effect of pharmaceutical interventions targeting thromboxane receptors and thromboxane synthase in cardiovascular and renal diseases.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Humans; Kidney Diseases; Platelet Aggregation Inhibitors; Proteinuria; Receptors, Thrombin; Thrombosis; Thromboxane A2; Thromboxane-A Synthase; Ticlopidine | 2009 |
Platelet function testing and implications for clinical practice.
Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Hemorrhage; Hemostasis; Humans; Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Predictive Value of Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk Assessment; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Antiplatelet resistance--fact or myth?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2009 |
Dental management of patients taking antiplatelet medications.
Topics: Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Dental Care for Chronically Ill; Humans; Oral Hemorrhage; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Thrombosis; Ticlopidine | 2009 |
[Perioperative antiplatelet therapy of patients with coronary stents].
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Cohort Studies; Coronary Disease; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Postoperative Complications; Practice Guidelines as Topic; Retrospective Studies; Risk Factors; Stents; Thrombosis; Ticlopidine; Time Factors | 2009 |
Platelet reactivity and nonresponse to dual antiplatelet therapy: a review.
Topics: Blood Platelets; Clinical Trials as Topic; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine | 2009 |
Comparison of prasugrel and clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Assessment; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Aspirin and clopidogrel hyporesponsiveness and nonresponsiveness in patients with coronary artery stenting.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Recurrence; Risk Assessment; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
[Medicinal therapy for interventional surgery of the peripheral vascular system].
Topics: Administration, Oral; Anticoagulants; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Drug Therapy, Combination; Heparin; Humans; Infusions, Intravenous; Ischemia; Leg; Long-Term Care; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Secondary Prevention; Thrombocytopenia; Thrombosis; Ticlopidine; Vitamin K | 2010 |
Prasugrel: Clinical development and therapeutic application.
Topics: Acute Coronary Syndrome; Angioplasty; Clopidogrel; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Thrombosis; Ticlopidine | 2009 |
[Thienopyridines in the treatment and prevention of cardiovascular diseases. Part IV. therapeutic application of clopidogrel in combination with acetylsalicylic acid in acute coronary syndromes and percutaneous coronary interventions].
Topics: Acute Coronary Syndrome; American Heart Association; Angioplasty, Balloon; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Thrombosis; Ticlopidine; United States | 2009 |
Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions.
Topics: Atherosclerosis; Clopidogrel; Forecasting; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine | 2010 |
Combination antithrombotic therapies.
Topics: Aspirin; Atherosclerosis; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Pyridines; Thrombosis; Ticlopidine | 2010 |
Relation of CYP2C19 loss-of-function polymorphism to the occurrence of stent thrombosis.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Stents; Thrombosis; Ticlopidine | 2010 |
Preventing serious sequelae after an acute coronary syndrome: the consequences of thrombosis versus bleeding with antiplatelet therapy.
Topics: Acute Coronary Syndrome; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Risk Factors; Thiophenes; Thrombosis; Ticlopidine | 2010 |
Prolonged infusion of eptifibatide as bridge therapy between bare-metal stent insertion and cardiovascular surgery: case report and review of the literature.
Topics: Angioplasty; Anticoagulants; Aspirin; Cardiovascular Surgical Procedures; Clopidogrel; Coronary Artery Bypass; Eptifibatide; Hemorrhage; Humans; Male; Metals; Middle Aged; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Thrombosis; Ticlopidine | 2010 |
Cytochrome P450 2C19*2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis.
Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Genetic Association Studies; Genotype; Humans; Middle Aged; Polymorphism, Genetic; Recurrence; Risk Factors; Thrombosis; Ticlopidine; United States | 2011 |
Diabetes and the platelet: toward new therapeutic paradigms for diabetic atherothrombosis.
Topics: Acute Coronary Syndrome; Apoptosis; Aspirin; Blood Platelets; Clopidogrel; Diabetes Complications; Diabetes Mellitus; Glycoproteins; Humans; Models, Biological; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Thiophenes; Thromboplastin; Thrombosis; Ticlopidine | 2010 |
Dosing strategies for antiplatelet therapy in percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clinical Protocols; Clopidogrel; Drug Administration Schedule; Drug Monitoring; Hemorrhage; Humans; Patient Selection; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Risk Assessment; Risk Factors; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
Drug-eluting stent thrombosis 1,659 days after stent deployment: case report and literature review.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Angiography; Drug Administration Schedule; Drug-Eluting Stents; Electrocardiography; Humans; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Prasugrel.
Topics: Acute Coronary Syndrome; Clinical Trials as Topic; Clopidogrel; Humans; Piperazines; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Stents; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
Controversies in oral antiplatelet therapy in patients undergoing aortocoronary bypass surgery.
Topics: Administration, Oral; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Thiophenes; Thrombosis; Ticlopidine | 2010 |
Controversies and future perspectives of antiplatelet therapy in secondary stroke prevention.
Topics: Aspirin; Blood-Brain Barrier; Cilostazol; Clopidogrel; Dipyridamole; Drug Interactions; Drug Therapy, Combination; Humans; Lactones; Naphthalenes; Platelet Aggregation Inhibitors; Propionates; Pyridines; Randomized Controlled Trials as Topic; Secondary Prevention; Stroke; Succinates; Tetrazoles; Thrombosis; Ticlopidine | 2010 |
A review of the use of common antiplatelet agents in orthopaedic practice.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Humans; Orthopedics; Perioperative Care; Platelet Aggregation Inhibitors; Preoperative Care; Stents; Thrombosis; Ticlopidine | 2010 |
Prognostic significance of high on-clopidogrel platelet reactivity after percutaneous coronary intervention: systematic review and meta-analysis.
Topics: Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Humans; Intention to Treat Analysis; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Prognosis; Stents; Thrombosis; Ticlopidine | 2010 |
[Thienopyridines in the treatment and prevention of cardiovascular diseases. Part V. Combination of clopidogrel and acetylsalicylic acid in the treatment of stable patients with atherothrombotic cardiovascular diseases].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Arteriosclerosis; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Circulation; Death, Sudden, Cardiac; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors; Streptokinase; Stroke; Thrombosis; Ticlopidine; Time Factors | 2010 |
A comparison of the metabolism of clopidogrel and prasugrel.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Carboxylic Ester Hydrolases; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Thiophenes; Thrombosis; Ticlopidine | 2010 |
Cytochrome P450 2C19 polymorphism is associated with poor clinical outcomes in coronary artery disease patients treated with clopidogrel.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Humans; Myocardial Infarction; Myocardial Ischemia; Odds Ratio; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Stents; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
[New aspects on "triple therapy" after coronary stent implantation].
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Risk Factors; Stents; Stroke; Thrombosis; Ticlopidine; Vitamin K | 2010 |
Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation Inhibitors; Risk; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
[New era in antiplatelet therapy based on results from recent clinical trials].
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 2011 |
Clopidogrel withdrawal: is there a "rebound" phenomenon?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Humans; Patient Selection; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Inhibition of the antithrombotic effects of clopidogrel by proton pump inhibitors: facts or fancies?
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Thrombosis; Ticlopidine | 2010 |
[Efficacy and safety of various doses of acetylsalicylic Acid in prevention of complications of atherothrombosis].
Topics: Aspirin; Blood Platelets; Blood Vessels; Cardiovascular Diseases; Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Dose-Response Relationship, Drug; Drug Dosage Calculations; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Assessment; Secondary Prevention; Stomach Ulcer; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
Safety and efficacy of triple antithrombotic therapy after percutaneous coronary intervention in patients needing long-term anticoagulation.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Patient Selection; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Warfarin | 2011 |
The role of antithrombotics in secondary stroke prevention.
Topics: Anticoagulants; Clopidogrel; Cyclooxygenase Inhibitors; Fibrinolytic Agents; Humans; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Thrombosis; Ticlopidine | 2010 |
Antiplatelet therapy in the perioperative period.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Therapy, Combination; Evidence-Based Medicine; Hemorrhage; Humans; Perioperative Period; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Patients with drug-eluting stents and management of their anticoagulant therapy in cutaneous surgery.
Topics: Anticoagulants; Aspirin; Clopidogrel; Dermatologic Surgical Procedures; Drug-Eluting Stents; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2011 |
Antiplatelet therapy after placement of a drug-eluting stent: a review of efficacy and safety studies.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
Monitoring the effectiveness of antiplatelet therapy: opportunities and limitations.
Topics: Aspirin; Clopidogrel; Drug Monitoring; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Pharmacology and clinical trials of reversibly-binding P2Y12 inhibitors.
Topics: Adenosine; Adenosine Monophosphate; Animals; Clinical Trials, Phase III as Topic; Clopidogrel; Humans; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Protein Binding; Purinergic P2Y Receptor Antagonists; Quinazolinones; Sulfonamides; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2011 |
High platelet reactivity and clinical outcome - fact and fiction.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Variation; Humans; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Genetic determinants of on-clopidogrel high platelet reactivity.
Topics: Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Aspirin; ATP Binding Cassette Transporter, Subfamily B; Biomarkers, Pharmacological; Blood Platelets; Clopidogrel; Drug Combinations; Genetic Testing; Humans; Liver; Mutation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prodrugs; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Clopidogrel hydrogen sulphate for atrial fibrillation.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Thrombosis; Ticlopidine | 2011 |
Clopidogrel response variability and the advent of personalised antiplatelet therapy. A bench to bedside journey.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Humans; In Vitro Techniques; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Precision Medicine; Prospective Studies; Receptors, Purinergic P2Y12; Risk Factors; Signal Transduction; Stents; Thrombosis; Ticlopidine; Translational Research, Biomedical | 2011 |
Does CYP2C19 inhibition lead to clopidogrel thrombogenicity?
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Combinations; Drug Interactions; Humans; Proton Pump Inhibitors; Thrombosis; Ticlopidine | 2011 |
Systematic review of thienopyridine discontinuation and its impact upon clinical outcomes.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Administration Schedule; Drug-Eluting Stents; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Clopidogrel "resistance": where are we now?
Topics: Clopidogrel; Dose-Response Relationship, Drug; Drug Resistance; Drug Substitution; Hemorrhage; Humans; Medication Adherence; Percutaneous Coronary Intervention; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Risk Factors; Thrombosis; Ticlopidine; Treatment Failure | 2013 |
High on treatment platelet reactivity.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Cyclooxygenase Inhibitors; Drug Interactions; Drug Resistance; Humans; Myocardial Ischemia; Platelet Activation; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
[Decreasing incidence of stent thrombosis].
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Immunoglobulin Fab Fragments; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Recurrence; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Outcome; Ventricular Dysfunction, Left | 2011 |
The gain-of-function variant allele CYP2C19*17: a double-edged sword between thrombosis and bleeding in clopidogrel-treated patients.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Predisposition to Disease; Genetic Variation; Hemorrhage; Humans; Odds Ratio; Phenotype; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
[Clopidogrel resistance--clinical significance, pathogenesis and potential solutions].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Prevalence; Thrombosis; Ticlopidine | 2011 |
Antiplatelet therapy in ENT surgery: a review.
Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Decision Making; Drug-Eluting Stents; Humans; Otorhinolaryngologic Surgical Procedures; Perioperative Care; Platelet Aggregation Inhibitors; Risk Factors; Thrombosis; Ticlopidine | 2012 |
CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Hemorrhage; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Randomized Controlled Trials as Topic; Risk; Thrombosis; Ticlopidine | 2011 |
Clopidogrel dilemma for orthopaedic surgeons.
Topics: Attitude of Health Personnel; Blood Loss, Surgical; Clopidogrel; Decision Making; Dose-Response Relationship, Drug; Drug-Eluting Stents; Evidence-Based Medicine; Female; Humans; Male; Orthopedic Procedures; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Practice Guidelines as Topic; Risk Assessment; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Cilostazol and primary-PCI: mirage or good alternative?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Arrhythmias, Cardiac; Aspirin; Cilostazol; Clopidogrel; Combined Modality Therapy; Coronary Restenosis; Drug Therapy, Combination; Heart Failure; Humans; Phosphodiesterase 3 Inhibitors; Platelet Aggregation Inhibitors; Prodrugs; Risk; Stents; Tetrazoles; Thrombosis; Ticlopidine | 2012 |
What do you do with the antiplatelet agents in patients with drug eluting stents who then receive a mechanical valve?
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Animals; Anticoagulants; Aspirin; Benchmarking; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Evidence-Based Medicine; Female; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Hemorrhage; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Prosthesis Design; Risk Assessment; Risk Factors; Sirolimus; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Systematic review and meta-analysis of the association between cytochrome P450 2C19 genotype and bleeding.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Hemorrhage; Humans; Polymorphism, Genetic; Risk; Thrombosis; Ticlopidine | 2012 |
[Platelet function: new drugs, new assays : possible impacts on operative medicine?].
Topics: Adenosine; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Postoperative Complications; Postoperative Hemorrhage; Practice Guidelines as Topic; Prasugrel Hydrochloride; Predictive Value of Tests; Stents; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2012 |
A brief review of the past and future of platelet P2Y12 antagonist.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Clopidogrel; Coronary Artery Disease; Humans; Myocardial Infarction; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Quinazolinones; Stents; Sulfonamides; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2012 |
Advances in platelet function testing assessing bleeding complications in patients with coronary artery disease.
Topics: Acute Coronary Syndrome; Aspirin; Blood Platelets; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Precision Medicine; Risk; Thrombosis; Ticlopidine | 2012 |
Stents and antiplatelet therapy.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Prosthesis Design; Risk Factors; Stents; Thienopyridines; Thrombosis; Ticlopidine | 2012 |
Primary prevention of ischaemic cardiovascular disorders with antiplatelet agents.
Topics: Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Humans; Ischemia; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Thrombosis; Ticlopidine | 2012 |
Underreporting of hemorrhagic and thrombotic complications of pharmaceuticals to the U.S. Food and Drug Administration: empirical findings for warfarin, clopidogrel, ticlopidine, and thalidomide from the Southern Network on Adverse Reactions (SONAR).
Topics: Adverse Drug Reaction Reporting Systems; Clopidogrel; Hemorrhage; Humans; Thalidomide; Thrombosis; Ticlopidine; United States; United States Food and Drug Administration; Warfarin | 2012 |
Comparing newer oral anti-platelets prasugrel and ticagrelor in reduction of ischemic events-evidence from a network meta-analysis.
Topics: Adenosine; Clopidogrel; Hemorrhage; Humans; Ischemia; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; PubMed; Randomized Controlled Trials as Topic; Stents; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2013 |
Platelet function monitoring and clopidogrel.
Topics: Blood Platelets; Clopidogrel; Drug Monitoring; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine | 2013 |
Antiplatelet drug resistance and variability in response: the role of antiplatelet therapy monitoring.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Cost Savings; Drug Monitoring; Drug Resistance; Drug Substitution; Drug Therapy, Combination; Humans; Ischemia; Platelet Aggregation Inhibitors; Secondary Prevention; Thrombosis; Ticlopidine | 2013 |
State of the art--a journey through the world of antithrombotic therapy.
Topics: Ambulatory Care; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Coronary Disease; Fibrinolytic Agents; Heart Failure; Hemorrhage; Heparin, Low-Molecular-Weight; Humans; Orthopedic Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Practice Guidelines as Topic; Recurrence; Respiratory Insufficiency; Thromboembolism; Thrombolytic Therapy; Thrombophlebitis; Thrombosis; Ticlopidine | 2002 |
The thienopyridine derivatives (platelet adenosine diphosphate receptor antagonists), pharmacology and clinical developments.
Topics: Anesthesia; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 2003 |
[Clopidogrel. Actions, pharmacokinetics, clinical studies].
Topics: Blood Platelets; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Thromboembolism; Thrombosis; Ticlopidine | 2002 |
Sirolimus-eluting stents: a review of experimental and clinical findings.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Animals; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Restenosis; Disease Models, Animal; Drug Delivery Systems; Follow-Up Studies; Humans; Immunosuppressive Agents; Injections, Intramuscular; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Rats; Sirolimus; Stents; Swine; Thrombosis; Ticlopidine; Time Factors; Ultrasonography, Interventional | 2002 |
Evidence with antiplatelet therapy and ADP-receptor antagonists.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Stroke; Thrombosis; Ticlopidine | 2003 |
[Platelet inhibitors: old and new].
Topics: Abciximab; Antibodies, Monoclonal; Arteriosclerosis; Aspirin; Clopidogrel; Coronary Disease; Dipyridamole; Drug Monitoring; Eptifibatide; Humans; Immunoglobulin Fab Fragments; Membrane Proteins; Patient Selection; Peptides; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombosis; Thromboxanes; Ticlopidine | 2002 |
[Clopidogrel: background information and use in clinical practice].
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Stroke; Thrombosis; Ticlopidine | 2003 |
What is the role for improved long-term antiplatelet therapy after percutaneous coronary intervention?
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Brachytherapy; Clopidogrel; Coronary Disease; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Endothelium, Vascular; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Thrombosis; Ticlopidine; Warfarin | 2003 |
Combined antiplatelet therapy in atrial fibrillation: review of the literature and future avenues.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Combinations; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2003 |
[Should we use clopidogrel instead of ticlopidine in elective coronary angioplasty?].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Thrombosis; Ticlopidine | 2003 |
Antiplatelet agents in atherothrombotic diseases.
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Dipyridamole; Humans; Ischemia; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Ticlopidine | 2004 |
Clopidogrel in the management of cerebrovascular events.
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Drug Costs; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Thrombosis; Ticlopidine | 2004 |
Antithrombotic drugs in vascular medicine: a historical perspective.
Topics: Administration, Oral; Anticoagulants; Aspirin; Blood Platelets; Clopidogrel; Endothelium, Vascular; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Ticlopidine | 2003 |
Oral antiplatelet therapy in cerebrovascular disease, coronary artery disease, and peripheral arterial disease.
Topics: Administration, Oral; Angina Pectoris; Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopidogrel; Coronary Artery Disease; Dipyridamole; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Stroke; Thrombosis; Ticlopidine | 2004 |
Platelet function testing in cardiovascular diseases.
Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Case Management; Clopidogrel; Drug Resistance; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Ticlopidine; Treatment Outcome | 2004 |
Optimal antithrombotic treatment for percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Blood Coagulation; Clinical Trials as Topic; Clopidogrel; Heparin, Low-Molecular-Weight; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Stents; Thrombin; Thrombosis; Ticlopidine; Treatment Outcome | 2005 |
P2Y receptor antagonists in thrombosis.
Topics: Adenosine Monophosphate; Animals; Clopidogrel; Humans; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Thrombosis; Ticlopidine | 2005 |
Platelet aggregation and adenosine diphosphate/adenosine triphosphate receptors: a historical perspective.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Calcium; Calcium Signaling; Clopidogrel; Cyclic AMP; Drug Resistance; Hemorrhagic Disorders; Hemostasis; Humans; Mice; Mice, Knockout; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Second Messenger Systems; Thrombosis; Ticlopidine | 2005 |
The P2 receptors in platelet function.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Blood Vessels; Cell Shape; Clopidogrel; Cytoplasmic Granules; Fibrinolytic Agents; Humans; Ion Transport; Membrane Proteins; Models, Biological; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor Cross-Talk; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Signal Transduction; Stress, Mechanical; Thrombosis; Ticlopidine | 2005 |
The platelet P2 receptors in thrombosis.
Topics: Adenosine Diphosphate; Animals; Blood Vessels; Clinical Trials as Topic; Clopidogrel; Fibrinolytic Agents; Hemorrhagic Disorders; Humans; Membrane Proteins; Mice; Mice, Knockout; Platelet Aggregation Inhibitors; Pyridines; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine | 2005 |
Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis.
Topics: Adenosine Diphosphate; Animals; Arteriosclerosis; Aspirin; Clinical Trials as Topic; Clopidogrel; Cohort Studies; Double-Blind Method; Drug Resistance; Fibrinolytic Agents; Forecasting; Humans; Membrane Proteins; Meta-Analysis as Topic; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridines; Randomized Controlled Trials as Topic; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombophilia; Thrombosis; Ticlopidine | 2005 |
Pharmacology of CS-747 (prasugrel, LY640315), a novel, potent antiplatelet agent with in vivo P2Y12 receptor antagonist activity.
Topics: Adenosine Diphosphate; Adult; Animals; Aspirin; Biotransformation; Clinical Trials, Phase I as Topic; Clopidogrel; Collagen; Drug Evaluation, Preclinical; Drug Synergism; Fibrinolytic Agents; Hemostasis; Humans; Male; Membrane Proteins; Molecular Structure; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Thrombin; Thrombosis; Ticlopidine | 2005 |
[Oral antithrombotic therapy in primary and secondary prevention].
Topics: Animals; Aspirin; Clopidogrel; Fibrinolytic Agents; Humans; Primary Prevention; Secondary Prevention; Thrombosis; Ticlopidine | 2005 |
[Mechanism and drug treatment of atherothrombosis].
Topics: Anticoagulants; Arteriosclerosis; Aspirin; C-Reactive Protein; CD40 Antigens; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombolytic Therapy; Thrombosis; Ticlopidine | 2005 |
[Advances in adjunctive pharmacological therapy for percutaneous coronary interventions].
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Cardiac Catheterization; Clopidogrel; Coronary Restenosis; Factor X; Fibrinolytic Agents; Follow-Up Studies; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Immunosuppressive Agents; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Risk Factors; Sirolimus; Stents; Thrombolytic Therapy; Thrombosis; Ticlopidine; Time Factors | 2005 |
Therapeutic approaches in arterial thrombosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Atherosclerosis; Blood Platelets; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; Disease Progression; Fibrinolytic Agents; Humans; Mice; Models, Biological; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Risk; Signal Transduction; Thrombosis; Ticlopidine; Time Factors | 2005 |
Determinants of the interindividual variability in response to antiplatelet drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Clopidogrel; Drug Interactions; Drug Resistance; Humans; Models, Biological; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk; Thrombosis; Ticlopidine; Treatment Outcome | 2005 |
[Variable extent of platelet responsiveness to clopidogrel inhibition: "clopidogrel resistance"?].
Topics: Angioplasty, Balloon; Clopidogrel; Dose-Response Relationship, Drug; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2; Thrombosis; Ticlopidine | 2005 |
[The new antithrombotic agents].
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Azetidines; Benzylamines; Clopidogrel; Fibrinolytic Agents; Glycine; Hirudins; Humans; Injections, Subcutaneous; Platelet Aggregation Inhibitors; Polysaccharides; Prodrugs; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine; Time Factors; Venous Thrombosis | 2005 |
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist.
Topics: Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2006 |
[PCI: state of the art].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Coronary Restenosis; Humans; Japan; Platelet Aggregation Inhibitors; Prognosis; Stents; Thrombosis; Ticlopidine | 2006 |
Thienopyridines in percutaneous coronary interventions: standard procedures and high risk subsets.
Topics: Angioplasty, Balloon, Coronary; Biocompatible Materials; Brachytherapy; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Humans; Metals; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2006 |
[Dual antithrombotic therapy after implantation of coronary stents].
Topics: Aspirin; Clopidogrel; Coronary Stenosis; Dose-Response Relationship, Drug; Drug Synergism; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2006 |
Clopidogrel resistance: myth or reality?
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2006 |
Aspirin resistance: does it exist and is it an important clinical problem?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Resistance; Humans; Myeloproliferative Disorders; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine | 2006 |
MATCH results: implications for the internist.
Topics: Aspirin; Atherosclerosis; Clopidogrel; Controlled Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Europe; Hemorrhage; Humans; Ischemic Attack, Transient; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Thrombosis; Ticlopidine; Treatment Failure; United States | 2006 |
Multiple coronary thrombosis and stent implantation to the subtotally occluded right renal artery in a patient with essential thrombocytosis: a case report with review.
Topics: Angina, Unstable; Angioplasty; Clopidogrel; Coronary Thrombosis; Female; Humans; Hypertension; Middle Aged; Platelet Aggregation Inhibitors; Renal Artery Obstruction; Thrombocythemia, Essential; Thrombosis; Ticlopidine | 2006 |
Does a coxib-associated thrombotic risk limit the clinical use of the compounds as analgesic, antiinflammatory drugs? Arguments against.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 2 Inhibitors; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Patient Selection; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Assessment; Thrombosis; Ticlopidine | 2006 |
Drug insight: antithrombotic therapy after percutaneous coronary intervention in patients with an indication for anticoagulation.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Heart Valve Prosthesis Implantation; Heparin; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Practice Guidelines as Topic; Risk Factors; Stents; Thrombosis; Ticlopidine; Venous Thrombosis; Warfarin | 2006 |
The relationship of platelet reactivity to the occurrence of post-stenting ischemic events: emergence of a new cardiovascular risk factor.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Combined Modality Therapy; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Humans; Myocardial Infarction; Myocardial Ischemia; Patient Selection; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Assessment; Risk Factors; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2006 |
Clopidogrel: a review of its use in the prevention of thrombosis.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Outcome | 2007 |
[Coronary stents, dual antiplatelet therapy and peri-operative problems].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine | 2007 |
Variable platelet response to aspirin and clopidogrel in atherothrombotic disease.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Biomarkers; Biotransformation; Blood Coagulation Tests; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Interactions; Drug Resistance; Hemorrhage; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thrombosis; Thromboxane A2; Thromboxane B2; Ticlopidine; Treatment Failure | 2007 |
Clinical aspects of platelet inhibitors and thrombus formation.
Topics: Aspirin; Atherosclerosis; Blood Platelets; Cardiovascular Diseases; Cilostazol; Clopidogrel; Dipyridamole; Drug Resistance; Humans; Pentanoic Acids; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2 Receptor Antagonists; Pyridines; Receptor, PAR-1; Stents; Tetrazoles; Thrombosis; Thromboxanes; Ticlopidine | 2007 |
Antiplatelet therapy for atherothrombotic disease: an update for the primary care physician.
Topics: Anticoagulants; Aspirin; Atherosclerosis; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Primary Health Care; Recurrence; Risk Assessment; Stroke; Syndrome; Thrombosis; Ticlopidine | 2007 |
Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease.
Topics: Angina, Unstable; Aspirin; Atherosclerosis; Biomarkers; Blood Platelets; Clopidogrel; Humans; Inflammation; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Stroke; Thrombosis; Ticlopidine | 2007 |
Con: continuation of aspirin/clopidogrel for cardiac surgery.
Topics: Aspirin; Cardiac Surgical Procedures; Clopidogrel; Drug Therapy, Combination; Heart Diseases; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Prognosis; Thrombosis; Ticlopidine | 2007 |
Pro: continuation of aspirin/clopidogrel for cardiac surgery.
Topics: Aspirin; Cardiac Surgical Procedures; Clopidogrel; Heart Diseases; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Prognosis; Thrombosis; Ticlopidine | 2007 |
Clopidogrel: an updated and comprehensive review.
Topics: Angioplasty, Balloon, Coronary; Animals; Aspirin; Clopidogrel; Drug Approval; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; United States; United States Food and Drug Administration | 2007 |
Coronary stents and noncardiac surgery.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug-Eluting Stents; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Surgical Procedures, Operative; Thrombosis; Ticlopidine | 2007 |
ADP receptor antagonism: what's in the pipeline?
Topics: Adenosine; Adenosine Monophosphate; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Coronary Disease; Humans; Membrane Proteins; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2007 |
Aspirin combined with clopidogrel (Plavix) decreases cardiovascular events in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Angina, Unstable; Aspirin; Clopidogrel; Coronary Artery Disease; Evidence-Based Medicine; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 2007 |
[Platelet response to aspirin and clopidogrel. Biochemical evaluation, clinical impact, and pharmacological modulation].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Flow Cytometry; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine | 2007 |
[Drug-eluting stent thrombosis and its pharmacological prevention].
Topics: Aspirin; Clopidogrel; Death, Sudden, Cardiac; Drug-Eluting Stents; Fibrinolytic Agents; Humans; Incidence; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Terminology as Topic; Thrombosis; Ticlopidine; Turkey | 2007 |
Individualized antithrombotic therapy in high risk patients after coronary stenting. A double-edged sword between thrombosis and bleeding.
Topics: Algorithms; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Blood Coagulation; Clopidogrel; Drug Resistance; Evidence-Based Medicine; Fibrinolytic Agents; Hemorrhage; Humans; Patient Selection; Perioperative Care; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Risk Factors; Stents; Thrombosis; Ticlopidine | 2008 |
Role of antiplatelet agents in the primary and secondary prevention of atherothrombotic events in high risk-patients.
Topics: Aspirin; Atherosclerosis; Clinical Trials as Topic; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Ischemia; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Thrombosis; Ticlopidine | 2008 |
Interaction effects and subgroup analyses in clinical trials: more than meets the eye?
Topics: Aspirin; Bias; Causality; Clinical Trials as Topic; Clopidogrel; Confounding Factors, Epidemiologic; Data Interpretation, Statistical; Effect Modifier, Epidemiologic; Factor Analysis, Statistical; Humans; Incidence; Linear Models; Platelet Aggregation Inhibitors; Probability; Reproducibility of Results; Research Design; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Antiplatelet agents and arterial thrombosis.
Topics: Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Primary Prevention; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine; Warfarin | 2008 |
Chronic antithrombotic therapy in post-myocardial infarction patients.
Topics: Anticoagulants; Aspirin; Azetidines; Benzylamines; Clopidogrel; Humans; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Activation; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Risk Factors; Thrombolytic Therapy; Thrombosis; Ticlopidine; Vitamin K; Warfarin | 2008 |
Antiplatelet strategies: evaluating their current role in the setting of acute coronary syndromes.
Topics: Abciximab; Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Blood Platelets; Clopidogrel; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Assessment; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Clinical considerations with the use of antiplatelet therapy in patients undergoing percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Guideline Adherence; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Impact of duration of clopidogrel prescription on outcome of DES as compared to BMS in primary angioplasty: a meta-regression analysis of randomized trials.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Prescriptions; Randomized Controlled Trials as Topic; Regression Analysis; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Novel antithrombotic drugs in development.
Topics: Amino Acid Sequence; Animals; Clinical Trials as Topic; Clopidogrel; Fibrinolytic Agents; Glycoproteins; Molecular Sequence Data; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein C; Thrombomodulin; Thrombosis; Ticlopidine | 1995 |
New thoughts on strategies for modulating platelet function through the inhibition of surface receptors.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; Drug Evaluation, Preclinical; Endothelium, Vascular; Humans; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Cell Surface; Signal Transduction; Thrombosis; Ticlopidine; Type C Phospholipases | 1996 |
Clinical pharmacology of the adenosine diphosphate (ADP) receptor antagonist, clopidogrel.
Topics: Adenosine Diphosphate; Animals; Arteriosclerosis; Aspirin; Clopidogrel; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Signal Transduction; Thrombosis; Ticlopidine | 1998 |
Antiplatelet therapy. Aspirin, ticlopidine/clopidogrel, and anti-integrin agents.
Topics: Aspirin; Clopidogrel; Humans; Integrins; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 1998 |
Low molecular weight heparins in the cardiac catheterization laboratory.
Topics: Abciximab; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Cardiac Catheterization; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Enoxaparin; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Tunica Intima | 1999 |
Clopidogrel: the future choice for preventing platelet activation during coronary stenting?
Topics: Clopidogrel; Coronary Disease; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 1999 |
Antiplatelet therapy in interventional cardiology: I. Newer oral antiplatelet agents.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine | 2000 |
Clopidogrel: a review of its use in the prevention of atherothrombosis.
Topics: Arteriosclerosis; Clinical Trials as Topic; Clopidogrel; Drug Interactions; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Stents; Thrombosis; Ticlopidine | 2000 |
Clopidogrel and coronary stenting: what is the next question?
Topics: Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine | 2000 |
Benefit of ADP receptor antagonists in atherothrombotic patients: new evidence.
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 2001 |
Aspirin in patients with coronary artery disease: is it simply irresistible?
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Benzamidines; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Cyclooxygenase Inhibitors; Diabetes Complications; Dipyridamole; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Endothelium, Vascular; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Oximes; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Randomized Controlled Trials as Topic; Stroke; Thrombosis; Thromboxane-A Synthase; Ticlopidine; Vasodilator Agents | 2001 |
New antiplatelet agents: ticlopidine and clopidogrel. Antiplatelet therapy but at what cost?
Topics: Aspirin; Bone Marrow; Clopidogrel; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2001 |
Atherothrombosis--the neurologist's point of view.
Topics: Clopidogrel; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Predictive Value of Tests; Risk Factors; Stroke; Thrombosis; Ticlopidine; Time Factors | 2001 |
[Antithrombotic treatment protocols in interventional cardiology].
Topics: Aspirin; Clopidogrel; Drug Resistance; Enoxaparin; Fibrinolytic Agents; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2001 |
The WRIST series--what have we learnt?
Topics: Aged; Angioplasty, Balloon, Coronary; Brachytherapy; Clopidogrel; Cohort Studies; Coronary Restenosis; Eptifibatide; Female; Follow-Up Studies; Gamma Rays; Humans; Iridium Radioisotopes; Male; Middle Aged; Multicenter Studies as Topic; Peptides; Placebos; Platelet Aggregation Inhibitors; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine; Time Factors; Yttrium Radioisotopes | 2002 |
Antithrombotic agents: implications in dentistry.
Topics: Anticoagulants; Aspirin; Blood Coagulation Tests; Clopidogrel; Dental Care; Drug Interactions; Embolism; Fibrinolytic Agents; Hemostasis; Heparin; Heparin, Low-Molecular-Weight; Humans; Oral Hemorrhage; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Ticlopidine; Tirofiban; Tyrosine; Venous Thrombosis; Warfarin | 2002 |
148 trial(s) available for clopidogrel and Thrombosis
| Article | Year |
|---|---|
Ischemic Events Occur Early in Patients Undergoing Percutaneous Coronary Intervention and Are Reduced With Cangrelor: Findings From CHAMPION PHOENIX.
Topics: Adenosine Monophosphate; Clopidogrel; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Thrombosis; Treatment Outcome | 2022 |
Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
Topics: Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Comorbidity; COVID-19; COVID-19 Drug Treatment; Extracorporeal Membrane Oxygenation; Female; Hemorrhage; Heparin; Hospital Mortality; Humans; Inpatients; Male; Medical Futility; Middle Aged; Outcome Assessment, Health Care; Oxygen Inhalation Therapy; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Respiration, Artificial; Thrombosis; Ticagrelor; Time Factors; Treatment Outcome | 2022 |
Ticagrelor versus clopidogrel in reducing inflammatory cell infiltration of thrombus aspirated in patients with ST-elevation myocardial infarction.
Topics: Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; ST Elevation Myocardial Infarction; Thrombosis; Ticagrelor; Treatment Outcome | 2022 |
CYP2C19 genotype-guided antithrombotic treatment versus conventional clopidogrel therapy in peripheral arterial disease: study design of a randomized controlled trial (GENPAD).
Topics: Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Myocardial Infarction; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Thrombosis; Treatment Outcome | 2022 |
Indobufen or Aspirin on Top of Clopidogrel After Coronary Drug-Eluting Stent Implantation (OPTION): A Randomized, Open-Label, End Point-Blinded, Noninferiority Trial.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Hemorrhage; Humans; Ischemic Stroke; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Treatment Outcome; Troponin | 2023 |
Aspirin Versus Clopidogrel for Long-Term Maintenance Monotherapy After Percutaneous Coronary Intervention: The HOST-EXAM Extended Study.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Treatment Outcome | 2023 |
Ticagrelor inhibits platelet aggregation and reduces inflammatory burden more than clopidogrel in patients with stages 4 or 5 chronic kidney disease.
Topics: Adenosine; Clopidogrel; Female; Humans; Inflammation; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Renal Insufficiency, Chronic; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2023 |
Efficacy and Safety of Glycoprotein IIb/IIIa Inhibitors on Top of Ticagrelor in STEMI: A Subanalysis of the ATLANTIC Trial.
Topics: Aged; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Complications; ST Elevation Myocardial Infarction; Survival Analysis; Thrombosis; Ticagrelor; Treatment Outcome | 2020 |
Rationale and design of "Can Very Low Dose Rivaroxaban (VLDR) in addition to dual antiplatelet therapy improve thrombotic status in acute coronary syndrome (VaLiDate-R)" study : A randomised trial modulating endogenous fibrinolysis in patients with acute
Topics: Acute Coronary Syndrome; Clopidogrel; Dose-Response Relationship, Drug; Dual Anti-Platelet Therapy; Factor Xa Inhibitors; Female; Fibrinolysis; Humans; Male; Platelet Aggregation Inhibitors; Rivaroxaban; Thrombelastography; Thrombosis; Ticagrelor | 2020 |
Aspirin, clopidogrel and prasugrel monotherapy in patients with type 2 diabetes mellitus: a double-blind randomised controlled trial of the effects on thrombotic markers and microRNA levels.
Topics: Aged; Aspirin; Biomarkers; Blood Coagulation; Clopidogrel; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Fibrin; Humans; Male; MicroRNAs; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Primary Prevention; Secondary Prevention; Thrombosis; Time Factors; Treatment Outcome | 2020 |
Ticagrelor versus clopidogrel for prevention of subclinical stent thrombosis detected by optical coherence tomography in patients with drug-eluting stent implantation-a multicenter and randomized study.
Topics: Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Thrombosis; Ticagrelor; Tomography, Optical Coherence | 2021 |
Implementation of a Reference-Scaled Average Bioequivalence Approach for Highly Variable Acetylsalicylic Acid in Fixed-Dose Combination with Clopidogrel Versus Enteric Aspirin in Chinese Subjects Under Fasting Conditions: A Phase 1, Open-Label, Randomized
Topics: Acute Coronary Syndrome; Adult; Area Under Curve; Asian People; Aspirin; Clopidogrel; Cross-Over Studies; Drug Combinations; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Male; Therapeutic Equivalency; Thrombosis; Ticlopidine | 2020 |
Pharmacokinetics and Bioequivalence of Clopidogrel Hydrogen Sulfate Tablets in Fed and Fasted Conditions: An Open-Label, Randomized, Semireplicated Crossover Study in Healthy Chinese Volunteers.
Topics: Acute Coronary Syndrome; Administration, Oral; Adult; Area Under Curve; Asian People; Atherosclerosis; Chromatography, Liquid; Clopidogrel; Coronary Restenosis; Cross-Over Studies; Drug Compounding; Fasting; Female; Healthy Volunteers; Humans; Male; Platelet Aggregation Inhibitors; Stents; Tandem Mass Spectrometry; Therapeutic Equivalency; Thrombosis | 2020 |
TicagRelor Or Clopidogrel in severe or terminal chronic kidney patients Undergoing PERcutaneous coronary intervention for acute coronary syndrome: The TROUPER trial.
Topics: Acute Coronary Syndrome; Adolescent; Adult; Aged; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Renal Insufficiency, Chronic; Secondary Prevention; Thrombosis; Ticagrelor; Young Adult | 2020 |
Rationale and design for the study Apixaban versus ClopidoGRel on a background of aspirin in patient undergoing InfraPoPliteal angioplasty for critical limb ischemia: AGRIPPA trial.
Topics: Angioplasty; Aspirin; Clopidogrel; Critical Illness; Factor Xa Inhibitors; Humans; Ischemia; Leg; Multicenter Studies as Topic; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Popliteal Artery; Postoperative Complications; Proof of Concept Study; Prospective Studies; Pyrazoles; Pyridones; Randomized Controlled Trials as Topic; Thrombosis | 2020 |
Aspirin with or without Clopidogrel after Transcatheter Aortic-Valve Implantation.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Incidence; Male; Platelet Aggregation Inhibitors; Postoperative Period; Thrombosis; Transcatheter Aortic Valve Replacement | 2020 |
Aspirin Versus Aspirin Plus Clopidogrel as Antithrombotic Treatment Following Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve: The ARTE (Aspirin Versus Aspirin + Clopidogrel Following Transcatheter Aortic Valve Implantation) Randomi
Topics: Aged; Aged, 80 and over; Aortic Valve; Aspirin; Balloon Valvuloplasty; Canada; Clopidogrel; Drug Therapy, Combination; Early Termination of Clinical Trials; Europe; Female; Fibrinolytic Agents; Heart Valve Prosthesis; Hemorrhage; Humans; Ischemic Attack, Transient; Kaplan-Meier Estimate; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Prosthesis Design; Risk Factors; South America; Stroke; Thrombosis; Ticlopidine; Time Factors; Transcatheter Aortic Valve Replacement; Treatment Outcome | 2017 |
Morphological and pharmacological determinants of peri-procedural myocardial infarction following elective stent implantation: Optical coherence tomography sub-analysis of the PRASFIT-Elective study.
Topics: Aged; Aspirin; Clopidogrel; Creatine Kinase, MB Form; Double-Blind Method; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stents; Thrombosis; Ticlopidine; Tomography, Optical Coherence | 2017 |
Effects of genetic variants on platelet reactivity and one-year clinical outcomes after percutaneous coronary intervention: A prospective multicentre registry study.
Topics: Aged; Aryldialkylphosphatase; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Postoperative Complications; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine | 2018 |
Ischaemic Events and Stent Thrombosis following Planned Discontinuation of Study Treatment with Ticagrelor or Clopidogrel in the PLATO Study.
Topics: Aged; Blood Platelets; Clopidogrel; Female; Humans; Ischemia; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticagrelor; Time Factors; Treatment Outcome | 2018 |
Tiny Cerebral Aneurysms Can Be Treated Safely and Effectively with Low-Profile Visualized Intraluminal Support Stent-Assisted Coiling or Coiling Alone.
Topics: Adult; Aged; Aneurysm, Ruptured; Aspirin; Clopidogrel; Embolization, Therapeutic; Endovascular Procedures; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Prospective Studies; Stents; Thrombosis; Ticlopidine | 2018 |
Edoxaban Plus Aspirin vs Dual Antiplatelet Therapy in Endovascular Treatment of Patients With Peripheral Artery Disease: Results of the ePAD Trial.
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Endovascular Procedures; Europe; Factor Xa Inhibitors; Female; Fibrinolytic Agents; Hemorrhage; Humans; Israel; Lower Extremity; Male; Middle Aged; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Proof of Concept Study; Prospective Studies; Pyridines; Recurrence; Risk Factors; Thiazoles; Thrombosis; Time Factors; Treatment Outcome; United States; Vascular Patency | 2018 |
Risk of intracranial hemorrhage (RICH) in users of oral antithrombotic drugs: Nationwide pharmacoepidemiological study.
Topics: Adolescent; Adult; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Dabigatran; Female; Fibrinolytic Agents; Humans; Intracranial Hemorrhages; Male; Middle Aged; Norway; Pharmacoepidemiology; Risk Factors; Rivaroxaban; Thrombosis; Warfarin | 2018 |
Risk of Postpolypectomy Bleeding With Uninterrupted Clopidogrel Therapy in an Industry-Independent, Double-Blind, Randomized Trial.
Topics: Aged; Cardiovascular Diseases; Clopidogrel; Colonic Polyps; Colonoscopy; Double-Blind Method; Female; Hospitalization; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Reoperation; Thrombosis; Time Factors | 2019 |
Guided de-escalation of DAPT in acute coronary syndrome patients undergoing percutaneous coronary intervention with BVS implantation: a post-hoc analysis from the randomized TROPICAL-ACS trial.
Topics: Absorbable Implants; Acute Coronary Syndrome; Adolescent; Adult; Aged; Aged, 80 and over; Blood Vessel Prosthesis Implantation; Clopidogrel; Drug Substitution; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thrombosis; Tissue Scaffolds; Young Adult | 2019 |
Efficacy and safety of 12 versus 48 months of dual antiplatelet therapy after implantation of a drug-eluting stent: the OPTImal DUAL antiplatelet therapy (OPTIDUAL) trial: study protocol for a randomized controlled trial.
Topics: Aspirin; Clinical Protocols; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; France; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Design; Research Design; Stroke; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Effect of platelet inhibition with cangrelor during PCI on ischemic events.
Topics: Adenosine Monophosphate; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Double-Blind Method; Female; Hemorrhage; Humans; Intention to Treat Analysis; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2013 |
Cost-effectiveness of ticagrelor versus clopidogrel for the prevention of atherothrombotic events in adult patients with acute coronary syndrome in Germany.
Topics: Acute Coronary Syndrome; Adenosine; Adult; Atherosclerosis; Clopidogrel; Cost-Benefit Analysis; Decision Trees; Double-Blind Method; Drugs, Generic; Follow-Up Studies; Germany; Humans; Markov Chains; Models, Economic; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Quality-Adjusted Life Years; Thrombosis; Ticagrelor; Ticlopidine; Time Factors | 2013 |
Ticagrelor in patients with acute coronary syndromes and stroke: interpretation of subgroups in clinical trials.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Secondary Prevention; Stroke; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
[Prevention of non-acute stent thrombosis after drug-eluting stent implantation].
Topics: Aspirin; Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Tirofiban; Tyrosine; Warfarin | 2013 |
Clopidogrel in infants with systemic-to-pulmonary-artery shunts.
Topics: Anastomosis, Surgical; Clopidogrel; Double-Blind Method; Female; Follow-Up Studies; Heart Defects, Congenital; Hemorrhage; Humans; Infant; Infant, Newborn; Kaplan-Meier Estimate; Male; Platelet Aggregation Inhibitors; Pulmonary Artery; Thrombosis; Ticlopidine | 2013 |
Pharmacodynamic effects of adjunctive high dose atorvastatin on double dose clopidogrel in patients with high on-treatment platelet reactivity depending on diabetes mellitus status.
Topics: Aged; Atorvastatin; Clopidogrel; Diabetes Mellitus; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Pyrroles; Thrombosis; Ticlopidine | 2014 |
Primary thrombophilia in México X: a prospective study of the treatment of the sticky platelet syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelet Disorders; Child; Clopidogrel; Female; Humans; Male; Mexico; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Syndrome; Thrombophilia; Thrombosis; Ticlopidine; Young Adult | 2015 |
Circadian variation of stent thrombosis and the effect of more robust platelet inhibition: a post hoc analysis of the TRITON-TIMI 38 trial.
Topics: Acute Coronary Syndrome; Aged; Circadian Rhythm; Clopidogrel; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stents; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Paraoxonase-1 activity affects the clopidogrel response in CYP2C19 loss-of-function carriers.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thrombosis; Ticlopidine | 2013 |
Three vs twelve months of dual antiplatelet therapy after zotarolimus-eluting stents: the OPTIMIZE randomized trial.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk; Sirolimus; Stroke; Thrombosis; Ticlopidine | 2013 |
Impact of intraprocedural stent thrombosis during percutaneous coronary intervention: insights from the CHAMPION PHOENIX Trial (Clinical Trial Comparing Cangrelor to Clopidogrel Standard of Care Therapy in Subjects Who Require Percutaneous Coronary Interv
Topics: Adenosine Monophosphate; Aged; Clopidogrel; Double-Blind Method; Female; Humans; Intraoperative Complications; Male; Middle Aged; Percutaneous Coronary Intervention; Prospective Studies; Standard of Care; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2014 |
Switching from clopidogrel to prasugrel in patients having coronary stent implantation.
Topics: Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Drug Substitution; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Renal Insufficiency, Chronic; Sex Factors; Stents; Thiophenes; Thrombosis; Ticlopidine | 2014 |
Inhibition of platelet activation could decrease thrombotic events in hemodialysis PF4/H antibody-positive patients.
Topics: Adult; Aged; Aspirin; Clopidogrel; Female; Humans; Incidence; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Factor 4; Renal Dialysis; Thrombosis; Ticlopidine | 2014 |
Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents.
Topics: Aged; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Ischemia; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine; Time Factors | 2014 |
Residual platelet reactivity to predict long-term clinical outcomes after clopidogrel loading in patients with acute coronary syndromes: comparison of different cutoff values by light transmission aggregometry from the responsiveness to clopidogrel and st
Topics: Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Cohort Studies; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Platelet reactivity after receiving clopidogrel compared with ticagrelor in patients with kidney failure treated with hemodialysis: a randomized crossover study.
Topics: Adenosine; Adult; Aspirin; Clopidogrel; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Renal Dialysis; Single-Blind Method; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2015 |
Generic Clopidogrel Besylate in the Secondary Prevention of Atherothrombotic Events: A 6-month Follow-up of a Randomised Clinical Trial.
Topics: Aged; Aged, 80 and over; Clopidogrel; Drugs, Generic; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2015 |
Preoperative platelet aggregation predicts perioperative blood loss and rethoracotomy for bleeding in patients receiving dual antiplatelet treatment prior to coronary surgery.
Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Drug Combinations; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Hemorrhage; Premedication; Prognosis; Reoperation; Reproducibility of Results; Sensitivity and Specificity; Thoracic Surgery; Thrombosis; Ticlopidine; Treatment Outcome | 2015 |
Genetic and platelet function testing of antiplatelet therapy for percutaneous coronary intervention: the ARCTIC-GENE study.
Topics: Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2015 |
Fixed and Modifiable Correlates of Drug-Eluting Stent Thrombosis From a Large All-Comers Registry: Insights From ADAPT-DES.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Patient Compliance; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Purinergic P2Y Receptor Antagonists; Risk Factors; Survival Analysis; Thrombosis; Ticlopidine; Ultrasonography, Interventional | 2015 |
Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model.
Topics: Adenosine; Anti-Inflammatory Agents; Biomarkers; Blood Platelets; Chemotaxis, Leukocyte; Clopidogrel; Cytokines; Endotoxins; England; Female; Fibrin Fibrinogen Degradation Products; Humans; Inflammation; Inflammation Mediators; Male; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombosis; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome; Young Adult | 2015 |
Effects of dabigatran on the cellular and protein phase of coagulation in patients with coronary artery disease on dual antiplatelet therapy with aspirin and clopidogrel. Results from a prospective, randomised, double-blind, placebo-controlled study.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Blood Coagulation; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 Enzyme System; Dabigatran; Double-Blind Method; Electrodes; Female; Humans; Light; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Thrombelastography; Thrombosis; Ticlopidine; Vitamin K | 2016 |
Differences in Whole Blood Platelet Aggregation at Baseline and in Response to Aspirin and Aspirin Plus Clopidogrel in Patients With Versus Without Chronic Kidney Disease.
Topics: Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Renal Insufficiency, Chronic; Thrombosis; Ticlopidine; Treatment Outcome | 2016 |
Impact of glycoprotein IIb/IIIa inhibitors on the efficacy and safety of ticagrelor compared with clopidogrel in patients with acute coronary syndromes: Analysis from the Platelet Inhibition and Patient Outcomes (PLATO) Trial.
Topics: Abciximab; Acute Coronary Syndrome; Adenosine; Aged; Antibodies, Monoclonal; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Eptifibatide; Female; Graft Occlusion, Vascular; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Peptides; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2Y Receptor Antagonists; Stroke; Thrombosis; Ticagrelor; Ticlopidine; Tirofiban; Tyrosine | 2016 |
Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke: Clopidogrel Plus Aspirin Versus Aspirin Alone.
Topics: Aged; Aspirin; Atherosclerosis; Brain; Brain Ischemia; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Thrombosis; Ticlopidine | 2016 |
Impact of oral P2Y12 inhibitors on residual thrombus burden and reperfusion indexes in patients with ST-segment elevation myocardial infarction.
Topics: Abciximab; Adenosine; Administration, Oral; Aged; Aged, 80 and over; Antibodies, Monoclonal; Clopidogrel; Coronary Angiography; Electrocardiography; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Reperfusion; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; ST Elevation Myocardial Infarction; Stents; Thrombectomy; Thrombosis; Ticagrelor; Ticlopidine; Tomography, Optical Coherence | 2016 |
Randomized evaluation of short-term dual antiplatelet therapy in patients with acute coronary syndrome treated with the COMBO dual therapy stent: rationale and design of the REDUCE trial.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Cause of Death; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Graft Occlusion, Vascular; Hemorrhage; Humans; Mortality; Myocardial Infarction; Myocardial Revascularization; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stroke; Thrombosis; Ticagrelor; Ticlopidine; Time Factors | 2016 |
Trial design: Rivaroxaban for the prevention of major cardiovascular events after transcatheter aortic valve replacement: Rationale and design of the GALILEO study.
Topics: Aortic Valve Stenosis; Aspirin; Cardiovascular Diseases; Cause of Death; Clopidogrel; Drug Therapy, Combination; Embolism; Factor Xa Inhibitors; Heart Valve Diseases; Humans; Mortality; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Care; Pulmonary Embolism; Rivaroxaban; Stroke; Thrombosis; Ticlopidine; Transcatheter Aortic Valve Replacement; Venous Thrombosis | 2017 |
Ischaemic and bleeding outcomes in elderly patients undergoing a prolonged versus shortened duration of dual antiplatelet therapy after percutaneous coronary intervention: insights from the PRODIGY randomised trial.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombosis; Ticlopidine | 2017 |
Genotyping-guided approach versus the conventional approach in selection of oral P2Y12 receptor blockers in Chinese patients suffering from acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Alleles; Asian People; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Expression; Gene Frequency; Genotype; Genotyping Techniques; Humans; Male; Middle Aged; Mutation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombosis; Ticagrelor; Ticlopidine | 2017 |
The clopidogrel resistance can be attenuated with triple antiplatelet therapy in patients undergoing drug-eluting stents implantation.
Topics: Aged; Cardiovascular Surgical Procedures; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombosis; Ticlopidine | 2009 |
Bivalirudin versus unfractionated heparin during percutaneous coronary intervention.
Topics: Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Double-Blind Method; Female; Hemorrhage; Heparin; Hirudins; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Premedication; Recombinant Proteins; Recurrence; Risk; Stents; Thrombosis; Ticlopidine | 2008 |
Antiplatelet response to the 150-mg maintenance dose of clopidogrel in patients with insufficient platelet inhibition after clopidogrel loading for elective coronary stent placement.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2008 |
Thrombotic events in high risk patients are predicted by evaluating different pathways of platelet function.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Likelihood Functions; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Risk Assessment; Risk Factors; ROC Curve; Thrombosis; Ticlopidine | 2008 |
The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic disease.
Topics: Aged; Aspirin; Body Mass Index; Clopidogrel; Coronary Disease; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Thrombosis; Ticlopidine | 2009 |
The antiplatelet effect of higher loading and maintenance dose regimens of clopidogrel: the PRINC (Plavix Response in Coronary Intervention) trial.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Female; Humans; Injections, Intravenous; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Verapamil | 2008 |
The pharmacogenetics and pharmacodynamics of clopidogrel response: an analysis from the PRINC (Plavix Response in Coronary Intervention) trial.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Gene Frequency; Genotype; Humans; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stents; Thrombosis; Ticlopidine; Time Factors | 2008 |
Influence of timing of clopidogrel treatment on the efficacy and safety of bivalirudin in patients with non-ST-segment elevation acute coronary syndromes undergoing percutaneous coronary intervention: an analysis of the ACUITY (Acute Catheterization and U
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Coronary Angiography; Drug Administration Schedule; Drug Therapy, Combination; Female; Hemorrhage; Heparin; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Risk Assessment; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Troponin; Young Adult | 2008 |
Safety and efficacy of biodegradable polymer-coated sirolimus-eluting stents in "real-world" practice: 18-month clinical and 9-month angiographic outcomes.
Topics: Aged; Angioplasty, Balloon, Coronary; Asia; Aspirin; Cardiovascular Agents; Clopidogrel; Coated Materials, Biocompatible; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymers; Product Surveillance, Postmarketing; Prospective Studies; Prosthesis Design; Registries; Risk Assessment; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Platelet aggregation inhibition in patients receiving statins either fully or partially metabolized by CYP3A4.
Topics: Aged; Anticholesteremic Agents; Atorvastatin; Clopidogrel; Cytochrome P-450 CYP3A; Drug Interactions; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Simvastatin; Thrombosis; Ticlopidine | 2008 |
Stent thrombosis up to 3 years after stenting for ST-segment elevation myocardial infarction versus for stable angina--comparison of the effects of drug-eluting versus bare-metal stents.
Topics: Angina Pectoris; Clopidogrel; Drug-Eluting Stents; Endpoint Determination; Humans; Myocardial Infarction; Pilot Projects; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
A comparison of anticoagulation with bivalirudin and provisional GPIIb/IIIa inhibition with unfractionated heparin and mandatory GPIIb/IIIa inhibition during percutaneous coronary intervention in relation to platelet activation and the inhibition of coagu
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Biomarkers; Blood Coagulation; CD40 Ligand; Clopidogrel; Drug Therapy, Combination; Female; Fibrinogen; Heparin; Hirudins; Humans; Lipoproteins; Male; Membrane Glycoproteins; Middle Aged; Monocytes; Peptide Fragments; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prothrombin; Recombinant Proteins; Thromboplastin; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Gastrointestinal bleeding in patients with acute coronary syndromes: incidence, predictors, and clinical implications: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial.
Topics: Acute Coronary Syndrome; Age Factors; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Coronary Artery Bypass; Female; Gastrointestinal Hemorrhage; Heparin; Hirudins; Humans; Incidence; Ischemia; Length of Stay; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Risk Assessment; Sex Factors; Stents; Thrombosis; Ticlopidine | 2009 |
Clopidogrel response status assessed with Multiplate point-of-care analysis and the incidence and timing of stent thrombosis over six months following coronary stenting.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Blood Coagulation Tests; Clopidogrel; Drug Monitoring; Drug Resistance; Drug-Eluting Stents; Female; Germany; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; ROC Curve; Thrombosis; Ticlopidine; Time Factors; Treatment Failure | 2010 |
A new oral antiplatelet agent with potent antithrombotic properties: comparison of DZ-697b with clopidogrel a randomised phase I study.
Topics: Administration, Oral; Adult; Bleeding Time; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2010 |
PROCLAIM: pilot study to examine the effects of clopidogrel on inflammatory markers in patients with metabolic syndrome receiving low-dose aspirin.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aspirin; Atherosclerosis; Biomarkers; C-Reactive Protein; CD40 Ligand; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Inflammation Mediators; Least-Squares Analysis; Male; Metabolic Syndrome; Middle Aged; Natriuretic Peptide, Brain; P-Selectin; Peptide Fragments; Pilot Projects; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; United States; Young Adult | 2009 |
Warfarin after anterior myocardial infarction in current era of dual antiplatelet therapy: a randomized feasibility trial.
Topics: Aged; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Embolism; Feasibility Studies; Female; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Ontario; Platelet Aggregation Inhibitors; Recurrence; Stroke; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography; Ventricular Dysfunction, Left; Warfarin | 2010 |
Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Predictive Value of Tests; Prospective Studies; Stents; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
Duration of dual antiplatelet therapy after implantation of drug-eluting stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retreatment; Stroke; Thrombosis; Ticlopidine | 2010 |
Bleeding complications with dual antiplatelet therapy among patients with stable vascular disease or risk factors for vascular disease: results from the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHAR
Topics: Aged; Aspirin; Clopidogrel; Disease Management; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Risk Factors; Survival Rate; Thrombosis; Ticlopidine; Vascular Diseases | 2010 |
Background, incidence, and predictors of antiplatelet therapy discontinuation during the first year after drug-eluting stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug-Eluting Stents; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Male; Medication Adherence; Middle Aged; Multivariate Analysis; Patient Readmission; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Renal Insufficiency; Self Medication; Thrombosis; Ticlopidine | 2010 |
Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2010 |
Enhanced platelet inhibition by adjunctive cilostazol to dual antiplatelet therapy after drug-eluting stent implantation for complex lesions.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Tetrazoles; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Clopidogrel resistance is associated with long-term thrombotic events in patients implanted with drug-eluting stents.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Resistance; Drug-Eluting Stents; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Thrombosis; Ticlopidine | 2010 |
Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk; Thrombosis; Ticlopidine | 2011 |
High on-treatment platelet reactivity to both aspirin and clopidogrel is associated with the highest risk of adverse events following percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Atherosclerosis; Clopidogrel; Drug Therapy, Combination; Female; Graft Occlusion, Vascular; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Stents; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Platelet inhibition by adjunctive cilostazol versus high maintenance-dose clopidogrel in patients with acute myocardial infarction according to cytochrome P450 2C19 genotype.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Chi-Square Distribution; Cilostazol; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Genotype; Humans; Korea; Liver; Male; Middle Aged; Myocardial Infarction; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Regression Analysis; Risk Assessment; Risk Factors; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Reduced thrombin formation and altered fibrin clot properties induced by polyunsaturated omega-3 fatty acids on top of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention (OMEGA-PCI clot).
Topics: Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Coagulation; C-Reactive Protein; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Dinoprost; Double-Blind Method; Down-Regulation; Drug Therapy, Combination; Fatty Acids, Omega-3; Female; Fibrin; Humans; Linear Models; Male; Middle Aged; Oxidative Stress; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Poland; Prospective Studies; Prothrombin; Thrombin; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Bleeding, mortality, and antiplatelet therapy: results from the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial.
Topics: Aged; Atherosclerosis; Cause of Death; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Global Health; Hemorrhage; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Risk Factors; Survival Rate; Thrombosis; Ticlopidine | 2011 |
CYP2C19*2 and other genetic variants affecting platelet response to clopidogrel in patients undergoing percutaneous coronary intervention.
Topics: Clopidogrel; Comorbidity; Coronary Artery Disease; Cytokines; Female; Genetic Predisposition to Disease; Greece; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Prevalence; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Platelet reactivity and cardiovascular outcomes after percutaneous coronary intervention: a time-dependent analysis of the Gauging Responsiveness with a VerifyNow P2Y12 assay: Impact on Thrombosis and Safety (GRAVITAS) trial.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Justification of 150 mg clopidogrel in patients with high on-clopidogrel platelet reactivity.
Topics: Aged; Angina, Stable; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stroke; Thrombosis; Ticlopidine; Time Factors | 2012 |
Coronary stenting with the Genous™ Bio-Engineered R Stent™ in elderly patients.
Topics: Age Factors; Aged; Angioplasty, Balloon, Coronary; Blood Vessel Prosthesis; Clopidogrel; Death; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Product Surveillance, Postmarketing; Registries; Risk Factors; Stents; Thrombosis; Ticlopidine | 2011 |
Evaluating the safety of very short-term (10 days) dual antiplatelet therapy after Genous™ bio-engineered R stent™ implantation: the multicentre pilot Genous trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Stenosis; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Italy; Male; Middle Aged; Myocardial Infarction; Pilot Projects; Platelet Aggregation Inhibitors; Prospective Studies; Prosthesis Design; Severity of Illness Index; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
The impact of genetic polymorphisms of P2Y12, CYP3A5 and CYP2C19 on clopidogrel response variability in Iranian patients.
Topics: Aryl Hydrocarbon Hydroxylases; Blood Platelets; Catheter Ablation; Clopidogrel; Cross-Sectional Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug-Eluting Stents; Female; Humans; Iran; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine | 2012 |
Pharmacodynamic effects of clopidogrel in pediatric cardiac patients: a comparative study of platelet aggregation response.
Topics: Adenosine Diphosphate; Adult; Arteries; Blood Platelets; Child, Preschool; Clopidogrel; Double-Blind Method; Female; Fetal Blood; Heart; Heart Diseases; Humans; Infant; Infant, Newborn; Male; Peptide Fragments; Placebos; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2012 |
Short- versus long-term duration of dual-antiplatelet therapy after coronary stenting: a randomized multicenter trial.
Topics: Aged; Aged, 80 and over; Aspirin; Cause of Death; Clopidogrel; Coronary Restenosis; Coronary Vessels; Drug Therapy, Combination; Drug-Eluting Stents; Everolimus; Female; Humans; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Risk; Sirolimus; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
The relationship between CYP2C19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: the CHARISMA genetics study.
Topics: Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Hemorrhage; Heterozygote; Humans; Ischemia; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stroke; Thrombosis; Ticlopidine | 2012 |
Earlier application of loading doses of aspirin and clopidogrel decreases rate of recurrent cardiovascular ischemic events for patients undergoing percutaneous coronary intervention.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Thrombelastography; Thrombosis; Ticlopidine | 2012 |
A randomized, double-blind, active-controlled phase 2 trial to evaluate a novel selective and reversible intravenous and oral P2Y12 inhibitor elinogrel versus clopidogrel in patients undergoing nonurgent percutaneous coronary intervention: the INNOVATE-PC
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Canada; Clopidogrel; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Europe; Female; Heart Diseases; Hemorrhage; Humans; Injections, Intravenous; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Quinazolinones; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Stroke; Sulfonamides; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; United States | 2012 |
Effect of cytochrome P450 2C19 polymorphism on target lesion outcome after drug-eluting stent implantation in japanese patients receiving clopidogrel.
Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Coronary Angiography; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Japan; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thrombosis; Ticlopidine | 2012 |
The impact of CYP3A5*1/*3, PIA1/A2 and T744C polymorphisms on clopidogrel and acetylsalicylic acid response variability in Mexican population.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Comorbidity; Cytochrome P-450 CYP3A; Drug Resistance; Female; Genetic Predisposition to Disease; Genetic Variation; Humans; Male; Mexico; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Single Nucleotide; Prevalence; Receptors, Purinergic P2Y12; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Prior smoking status, clinical outcomes, and the comparison of ticagrelor with clopidogrel in acute coronary syndromes-insights from the PLATelet inhibition and patient Outcomes (PLATO) trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Factors; Smoking; Stents; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
Microvascular effect of intracoronary eptifibatide in acute myocardial infarction.
Topics: Adolescent; Adult; Clopidogrel; Coronary Angiography; Echocardiography; Electrocardiography; Eptifibatide; Female; Humans; Male; Microcirculation; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Peptides; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Thrombosis; Ticlopidine; Treatment Outcome; Young Adult | 2012 |
Thrombus and antiplatelet therapy in type 2 diabetes mellitus. A prospective study after non-ST elevation acute coronary syndrome and a randomised, blinded, placebo-controlled study in stable angina.
Topics: Acute Coronary Syndrome; Aged; Angina, Stable; Aspirin; Clopidogrel; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Thrombosis; Ticlopidine | 2012 |
A randomized comparison of platelet reactivity in patients after treatment with various commercial clopidogrel preparations: the CLO-CLO trial.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Clopidogrel; Cross-Over Studies; Drugs, Generic; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Patient Selection; Percutaneous Coronary Intervention; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Single-Blind Method; Stents; Therapeutic Equivalency; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Adjunctive cilostazol versus high maintenance dose of clopidogrel in patients with hyporesponsiveness to chronic clopidogrel therapy.
Topics: Adult; Aged; Blood Platelets; Cilostazol; Clopidogrel; Cross-Over Studies; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Receptors, Purinergic P2Y12; Tetrazoles; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Reduction in first and recurrent cardiovascular events with ticagrelor compared with clopidogrel in the PLATO Study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Secondary Prevention; Severity of Illness Index; Stroke; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Efficacy and safety of triple antiplatelet therapy in obese patients undergoing stent implantation.
Topics: Adult; Aged; Aspirin; Blood Platelets; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Obesity; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Implantation; Stents; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
Effectiveness of clopidogrel versus aspirin in preventing acute myocardial infarction in patients with symptomatic atherothrombosis (CAPRIE trial).
Topics: Age Factors; Aged; Aspirin; Clopidogrel; Creatinine; Diabetes Mellitus; Female; Humans; Male; Massachusetts; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome | 2002 |
Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome | 2002 |
The Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) study: to what extent should the results be generalizable?
Topics: Angina, Unstable; Aspirin; Clopidogrel; Coronary Disease; Double-Blind Method; Female; Heart Failure; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Stents; Stroke; Thrombosis; Ticlopidine | 2003 |
Randomized controlled trial of clopidogrel plus aspirin to prevent hemodialysis access graft thrombosis.
Topics: Aged; Aspirin; Catheters, Indwelling; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Platelet Aggregation Inhibitors; Polytetrafluoroethylene; Renal Dialysis; Thrombosis; Ticlopidine | 2003 |
Management of atherothrombosis with clopidogrel in high-risk patients with recent transient ischaemic attack or ischaemic stroke (MATCH): study design and baseline data.
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Thrombosis; Ticlopidine | 2004 |
Failure of clopidogrel to reduce platelet reactivity and activation following standard dosing in elective stenting: implications for thrombotic events and restenosis.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Clopidogrel; Coronary Restenosis; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Failure | 2004 |
Is a 300 mg clopidogrel loading dose sufficient to inhibit platelet function early after coronary stenting? A platelet function profile study.
Topics: Adenosine Diphosphate; Clopidogrel; Coronary Vessels; Female; Fibrinogen; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Premedication; Stents; Thrombosis; Ticlopidine; von Willebrand Factor | 2004 |
Clopidogrel added to aspirin versus aspirin alone in secondary prevention and high-risk primary prevention: rationale and design of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial.
Topics: Arteriosclerosis; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Humans; Middle Aged; Platelet Aggregation Inhibitors; Primary Prevention; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Thrombosis; Ticlopidine | 2004 |
Preventive administration of Clopidogrel after restoring patency of acute dialysis fistula with surgical thrombectomy.
Topics: Adult; Aged; Arteriovenous Shunt, Surgical; Clopidogrel; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Renal Dialysis; Thrombectomy; Thrombosis; Ticlopidine; Treatment Outcome | 2003 |
Magnetic Vascular Port in minimally invasive direct coronary artery bypass grafting.
Topics: Aged; Aspirin; Clopidogrel; Comorbidity; Coronary Angiography; Drug Therapy, Combination; Equipment Design; Female; Follow-Up Studies; Humans; Internal Mammary-Coronary Artery Anastomosis; Magnetics; Male; Middle Aged; Minimally Invasive Surgical Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Surgical Instruments; Thrombosis; Ticlopidine; Treatment Outcome; Vascular Patency | 2004 |
A randomized comparison of the effects of aspirin and clopidogrel on thrombotic risk factors and C-reactive protein following myocardial infarction: the CADET trial.
Topics: Aged; Aspirin; Biomarkers; Blood Coagulation Factors; Blood Viscosity; C-Reactive Protein; Clopidogrel; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Thrombosis; Ticlopidine | 2004 |
The difference between clopidogrel responsiveness and posttreatment platelet reactivity.
Topics: Adenosine Diphosphate; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Predictive Value of Tests; Prognosis; Risk; Stents; Thrombosis; Ticlopidine | 2005 |
Does pre-treatment with aspirin and loading dose clopidogrel obviate the need for glycoprotein IIb/IIIa antagonists during elective coronary stenting? A focus on peri-procedural myonecrosis.
Topics: Abciximab; Aged; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Creatine Kinase; Creatine Kinase, MB Form; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Isoenzymes; Logistic Models; Male; Middle Aged; Neovascularization, Pathologic; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Premedication; Recurrence; Stents; Survival Rate; Thrombosis; Ticlopidine; Troponin T | 2005 |
Comparison of cilostazol and clopidogrel after successful coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Coronary Restenosis; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2005 |
Superior efficacy of clopidogrel plus acetylsalicylic acid compared with extended-release dipyridamole plus acetylsalicylic acid in preventing arterial thrombogenesis in healthy volunteers.
Topics: Adolescent; Adult; Arteries; Aspirin; Clopidogrel; Collagen; Cross-Over Studies; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; Fibrin; Humans; Immunoenzyme Techniques; Male; Perfusion; Platelet Adhesiveness; Platelet Function Tests; Thrombosis; Ticlopidine | 2005 |
Clopidogrel diminishes hemodialysis access graft thrombosis.
Topics: Aged; Catheters, Indwelling; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polytetrafluoroethylene; Prospective Studies; Renal Dialysis; Thrombosis; Ticlopidine | 2006 |
Anti-thrombotic action of clopidogrel and P1(A1/A2) polymorphism of beta3 integrin in patients with coronary artery disease not being treated with aspirin.
Topics: Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Genotype; Humans; Integrin beta3; Male; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Prothrombin; Thrombosis; Ticlopidine; Time Factors | 2005 |
Antithrombotic effects of ximelagatran plus acetylsalicylic acid (ASA) and clopidogrel plus ASA in a human ex vivo arterial thrombosis model.
Topics: Administration, Oral; Adult; Anticoagulants; Arteries; Aspirin; Azetidines; Benzylamines; Bleeding Time; Blood Coagulation; Clopidogrel; Dose-Response Relationship, Drug; Fibrinolytic Agents; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thrombosis; Ticlopidine | 2006 |
Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clopidogrel; Data Interpretation, Statistical; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Risk Factors; Stroke; Thrombosis; Ticlopidine | 2006 |
Monitoring platelet inhibition after clopidogrel with the VerifyNow-P2Y12(R) rapid analyzer: the VERIfy Thrombosis risk ASsessment (VERITAS) study.
Topics: Adenosine Diphosphate; Adult; Aged; Alprostadil; Blood Platelets; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Stents; Thrombosis; Ticlopidine | 2007 |
Cardiac events after low osmolar ionic or isosmolar nonionic contrast media utilization in the current era of coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Contrast Media; Coronary Angiography; Drug Delivery Systems; Enoxaparin; Female; Humans; Incidence; Ioxaglic Acid; Male; Middle Aged; Osmolar Concentration; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Risk Factors; Stents; Thrombosis; Ticlopidine; Triiodobenzoic Acids | 2006 |
Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel.
Topics: Aged; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Embolism, Cholesterol; Enzyme Inhibitors; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Thrombosis; Ticlopidine | 2006 |
Erythrocyte deformability and white blood cell count are associated with aspirin resistance in high-risk vascular patients.
Topics: Aged; Angina, Unstable; Aspirin; Bleeding Time; Blood Viscosity; Clopidogrel; Drug Resistance; Erythrocyte Deformability; Female; Hemorheology; Humans; Leukocyte Count; Leukocytes; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2006 |
Diabetes mellitus and platelet function after administration of aspirin and a single 600 mg dose of clopidogrel.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Diabetes Complications; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Thrombin; Thrombosis; Ticlopidine | 2006 |
Thromboelastography: potential bedside tool to assess the effects of antiplatelet therapy?
Topics: Adult; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Thrombelastography; Thrombosis; Ticlopidine; Time Factors | 2006 |
Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: design and rationale for the TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet InhibitioN with prasugrel Thrombolysis In Myocardial Infar
Topics: Acute Disease; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Follow-Up Studies; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Research Design; Syndrome; Thiophenes; Thrombolytic Therapy; Thrombosis; Ticlopidine; Treatment Outcome | 2006 |
A double-blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75 mg of clopidogrel for 30 days.
Topics: Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboembolism; Thrombosis; Ticlopidine | 2007 |
Effects of persistent platelet reactivity despite aspirin therapy on cardiac troponin I and creatine kinase-MB levels after elective percutaneous coronary interventions.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Clopidogrel; Coronary Artery Disease; Creatine Kinase, MB Form; Drug Resistance; Female; Humans; Male; Middle Aged; Myocardium; Necrosis; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Tablets, Enteric-Coated; Thrombosis; Ticlopidine; Time Factors; Troponin I; Up-Regulation | 2008 |
Therapeutic benefit of low-dose clopidogrel in patients undergoing carotid surgery is linked to variability in the platelet adenosine diphosphate response and patients' weight.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Body Weight; Clopidogrel; Endarterectomy, Carotid; Humans; Placebos; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Complications; Statistics as Topic; Thrombosis; Ticlopidine | 2007 |
The paclitaxel-eluting Coroflex Please stent pilot study (PECOPS I) : the one-year clinical follow-up.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Death; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Paclitaxel; Pilot Projects; Platelet Aggregation Inhibitors; Prospective Studies; Survival Rate; Thrombosis; Ticlopidine; Tubulin Modulators | 2007 |
Prasugrel versus clopidogrel in patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Stroke; Thiophenes; Thrombosis; Ticlopidine | 2007 |
The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosis.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cell Adhesion Molecules; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Research Design; Risk Assessment; Risk Factors; ROC Curve; Sensitivity and Specificity; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Functional impact of high clopidogrel maintenance dosing in patients undergoing elective percutaneous coronary interventions. Results of a randomized study.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Florida; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Research Design; Spain; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Residual prothrombotic status in low responder patients to clopidogrel identified by Vasodilator-Stimulated Phosphoprotein Phosphorylation (VASP) analysis?
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Aged, 80 and over; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Ischemia; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Recurrence; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomi
Topics: Acute Coronary Syndrome; Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stents; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
[The TRITON-TIMI 38 trial].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine | 2008 |
Approaching an age of reason with antiplatelet therapy.
Topics: Clopidogrel; Coronary Disease; Humans; Membrane Proteins; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Thiophenes; Thrombosis; Ticlopidine | 2008 |
Pharmacokinetics of clopidogrel in patients with stent thrombosis.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Pharmacokinetics; Platelet Aggregation; Platelet Function Tests; Stents; Thrombosis; Ticlopidine | 2008 |
Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial.
Topics: Adult; Aged; Arteriovenous Shunt, Surgical; Clopidogrel; Double-Blind Method; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Renal Dialysis; Thrombosis; Ticlopidine; Vascular Patency | 2008 |
Clopidogrel--a platelet inhibitor which inhibits thrombogenesis in non-anticoagulated human blood independently of the blood flow conditions.
Topics: Adult; Anticoagulants; Blood Flow Velocity; Clopidogrel; Fibrin; Fibrinopeptide A; Hematologic Tests; Humans; Male; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Count; Thrombosis; Ticlopidine | 1994 |
[Recent antithrombotic gold standard?].
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Outcome | 1997 |
Early potent antithrombotic effect with combined aspirin and a loading dose of clopidogrel on experimental arterial thrombogenesis in humans.
Topics: Adult; Arteries; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Time Factors | 2000 |
Prolonged antiplatelet therapy to prevent late thrombosis after intracoronary gamma-radiation in patients with in-stent restenosis: Washington Radiation for In-Stent Restenosis Trial plus 6 months of clopidogrel (WRIST PLUS).
Topics: Aged; Clopidogrel; Coronary Angiography; Coronary Disease; Female; Follow-Up Studies; Gamma Rays; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2001 |
537 other study(ies) available for clopidogrel and Thrombosis
| Article | Year |
|---|---|
Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Dogs; Humans; Niacin; Receptors, Purinergic P2Y12; Sulfonamides; Thrombosis | 2013 |
Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet
Topics: Administration, Oral; Animals; Dogs; Half-Life; Macaca fascicularis; Phenylurea Compounds; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Rats; Receptors, Purinergic P2Y1; Structure-Activity Relationship; Thiazoles; Thrombosis; Urea | 2014 |
Discovery of 4-aryl-7-hydroxyindoline-based P2Y1 antagonists as novel antiplatelet agents.
Topics: Animals; Blood Coagulation; Dose-Response Relationship, Drug; Drug Discovery; Humans; Indoles; Mice; Microsomes, Liver; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Rabbits; Rats; Receptors, Purinergic P2Y1; Structure-Activity Relationship; Thrombosis | 2014 |
N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Administration, Oral; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Indoles; Injections, Intravenous; Male; Models, Chemical; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2Y12; Thrombosis | 2014 |
Synthesis and evaluation of dual antiplatelet activity of bispidine derivatives of N-substituted pyroglutamic acids.
Topics: Animals; Blood Coagulation; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Hemorrhage; Humans; Mice; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Pyrrolidonecarboxylic Acid; Thrombosis | 2016 |
Discovery of novel, potent, isosteviol-based antithrombotic agents.
Topics: Animals; Diterpenes, Kaurane; Drug Discovery; Factor Xa Inhibitors; Female; Fibrinolytic Agents; Humans; Male; Partial Thromboplastin Time; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thrombin; Thrombosis | 2019 |
Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.
Topics: Benzofurans; Blood Platelets; Humans; Imidazoles; Morpholines; Platelet Aggregation; Receptor, PAR-1; Receptors, Thrombin; Thiazoles; Thrombin; Thrombosis | 2022 |
Platelet reactivity and clinical outcomes following percutaneous coronary intervention in complex higher-risk patients.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Risk Assessment; Thrombosis | 2022 |
Preparation of injectable clopidogrel loaded submicron emulsion for enhancing physicochemical stability and anti-thrombotic efficacy.
Topics: Animals; Clopidogrel; Emulsions; Particle Size; Percutaneous Coronary Intervention; Thrombosis | 2022 |
Should patients with non-muscle-invasive bladder cancer discontinue fibrin clot inhibitors during bacille Calmette-Guérin?
Topics: Adjuvants, Immunologic; Administration, Intravesical; Anticoagulants; Aspirin; BCG Vaccine; Clopidogrel; Fibrin; Humans; Neoplasm Recurrence, Local; Thrombosis; Urinary Bladder Neoplasms; Warfarin | 2022 |
COX-1, COX-2 and CYP2C19 variations may be related to cardiovascular events due to acetylsalicylic acid resistance.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase 2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Resistance; Genotype; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2022 |
Eculizumab for refractory thrombosis in antiphospholipid syndrome.
Topics: Adolescent; Antibodies, Monoclonal, Humanized; Antiphospholipid Syndrome; Aspirin; Clopidogrel; Female; Fondaparinux; Humans; Hydroxychloroquine; Thrombosis | 2022 |
Both G protein-coupled and immunoreceptor tyrosine-based activation motif receptors mediate venous thrombosis in mice.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; GTP-Binding Proteins; Immunoreceptor Tyrosine-Based Activation Motif; Mice; Mice, Transgenic; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thrombosis; Venous Thrombosis | 2022 |
Clinical features and posttreatment monitoring of dogs administered rivaroxaban (2018-2020): 19 cases.
Topics: Animals; Anticoagulants; Clopidogrel; Dog Diseases; Dogs; Factor Xa Inhibitors; Humans; Retrospective Studies; Rivaroxaban; Thrombosis | 2022 |
Surrogates of the Left Ventricular Thrombus Resolution: A Retrospective Data Review.
Topics: Adolescent; Adult; Aged; Anticoagulants; Clopidogrel; Echocardiography; Female; Heart Defects, Congenital; Humans; Male; Middle Aged; Retrospective Studies; Thrombosis | 2022 |
Comparison of Ischemic and Bleeding Events Between Short-Duration Versus Long-Duration Tirofiban Regimens in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention.
Topics: Clopidogrel; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Retrospective Studies; ST Elevation Myocardial Infarction; Thrombosis; Ticagrelor; Tirofiban; Treatment Outcome | 2022 |
Safety and efficacy comparison between OACs plus single antiplatelet and dual antiplatelet therapy in patients with cerebral venous sinus stenosis poststenting.
Topics: Adult; Anticoagulants; Aspirin; Clopidogrel; Constriction, Pathologic; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombosis; Treatment Outcome | 2022 |
Variability of antiplatelet response in patients with peripheral artery disease.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Prospective Studies; Thrombosis; Treatment Outcome | 2023 |
Elevated serum C1q is an independent predictor of high residual platelet reactivity in CAD patients receiving clopidogrel therapy.
Topics: Adenosine; Adenosine Diphosphate; Clopidogrel; Complement C1q; Coronary Artery Disease; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Ticagrelor; Ticlopidine | 2022 |
A rare cause of abdominal pain managed unconventionally: acute renal infarction caused by atrial fibrillation: a case report.
Topics: Abdominal Pain; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Diltiazem; Humans; Infarction; Male; Nitroglycerin; Platelet Aggregation Inhibitors; Thromboembolism; Thrombosis; Warfarin | 2022 |
Multiple genetic mutations increase the risk of thrombosis associated with clopidogrel after percutaneous coronary intervention.
Topics: Aryldialkylphosphatase; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Outcome | 2023 |
An elderly case with late carotid stent thrombosis: possible role of antiphospholipid antibodies.
Topics: Aged; Antibodies, Antiphospholipid; Carotid Artery Thrombosis; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Constriction, Pathologic; Humans; Male; Stents; Thrombosis | 2023 |
Revascularization of acute stent thrombosis caused by diarrhea after carotid artery stenting in an intermediate clopidogrel metabolizer.
Topics: Carotid Arteries; Carotid Stenosis; Clopidogrel; Diarrhea; Endarterectomy, Carotid; Humans; Stents; Stroke; Thrombosis; Treatment Outcome | 2023 |
Thrombotic risk in patients with acute coronary syndromes discharged on prasugrel or clopidogrel: results from the PROMETHEUS study.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Patient Discharge; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Thrombosis; Treatment Outcome | 2023 |
Secondary right atrial thrombosis in three dogs: Antithrombotics therapy and echocardiographic follow-up.
Topics: Animals; Atrial Fibrillation; Clopidogrel; Dog Diseases; Dogs; Echocardiography; Fibrinolytic Agents; Follow-Up Studies; Heart Atria; Heart Diseases; Rivaroxaban; Thrombosis | 2023 |
Thrombus architecture is influenced by the antiplatelet loading treatment in patients with acute myocardial infarction.
Topics: Clopidogrel; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; RNA; ST Elevation Myocardial Infarction; Thrombosis; Treatment Outcome | 2023 |
Validation of the Spartan RXCYP2C19 Genotyping Assay Utilizing Blood Samples.
Topics: Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; DNA; Dual Anti-Platelet Therapy; Genotyping Techniques; Humans; Mouth Mucosa; Percutaneous Coronary Intervention; Pharmacogenomic Testing; Pharmacogenomic Variants; Pharmacology, Clinical; Postoperative Complications; Reagent Kits, Diagnostic; Reference Standards; Reproducibility of Results; Stents; Thrombosis; Time Factors | 2020 |
Cutaneous thrombosis associated with eltrombopag treatment for immune thrombocytopenia.
Topics: Aged; Benzoates; Biopsy; Clopidogrel; Computed Tomography Angiography; Conservative Treatment; Female; Humans; Hydrazines; Hyperbaric Oxygenation; Ischemia; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Pyrazoles; Skin; Thrombosis; Tibial Arteries; Toes; Treatment Outcome; Warfarin | 2020 |
Ticagrelor or Prasugrel for Prevention of Stent Thrombosis?
Topics: Clopidogrel; Humans; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Prescriptions; Purinergic P2Y Receptor Antagonists; Registries; Stents; Thrombosis; Ticagrelor | 2020 |
Comparison of Age (<75 Years Vs ≥75 Years) and Platelet Reactivity to the Risk of Thrombotic and Bleeding Events After Successful Percutaneous Coronary Intervention With Drug-Eluting Stents (from the ADAPT-DES Study).
Topics: Acute Coronary Syndrome; Adult; Age Factors; Aged; Aged, 80 and over; Aspirin; Cause of Death; Clopidogrel; Drug-Eluting Stents; Graft Occlusion, Vascular; Hemorrhage; Humans; Middle Aged; Mortality; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Recurrence; Thrombosis; Young Adult | 2020 |
Anticoagulant and anti-thrombotic therapy in acute type B aortic dissection: when real-life scenarios face the shadows of the evidence-based medicine.
Topics: Anticoagulants; Aortic Aneurysm, Thoracic; Aortic Dissection; Aspirin; Clinical Decision-Making; Clopidogrel; Coronary Stenosis; Disease Progression; Drug-Eluting Stents; Dual Anti-Platelet Therapy; Fibrinolytic Agents; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Risk Assessment; Thrombosis; Treatment Outcome; Warfarin | 2020 |
Cost-effective analysis of clopidogrel versus aspirin for high risk patients with established peripheral arterial disease in China.
Topics: Aspirin; Clopidogrel; Cost-Benefit Analysis; Health Expenditures; Humans; Markov Chains; Models, Econometric; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Secondary Prevention; Thrombosis | 2020 |
A Pharmacodynamic Study of CN-218, a Novel Antiplatelet and Antithrombotic Agent Primarily Targeting the P2Y
Topics: Animals; Blood Coagulation; Blood Platelets; Carrageenan; Clopidogrel; Cyclic AMP; Disease Models, Animal; Fibrinolytic Agents; Hemorrhage; Male; Mice; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Rats, Wistar; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis | 2020 |
Laboratory assessments of therapeutic platelet inhibition in endovascular neurosurgery: complication prediction using the VerifyNow P2Y12 assay and thromboelastography with platelet mapping.
Topics: Adult; Aged; Blood Platelets; Carotid Arteries; Clopidogrel; Dose-Response Relationship, Drug; Endovascular Procedures; Female; Humans; Intracranial Hemorrhages; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Thrombelastography; Thromboembolism; Thrombosis | 2020 |
Reccurent thrombus in the gigantic left atrium during effective anticoagulant therapy: case report.
Topics: Aged; Clopidogrel; Drug Therapy, Combination; Factor Xa Inhibitors; Heart Atria; Heart Diseases; Heart Valve Prosthesis Implantation; Humans; Male; Mitral Valve Annuloplasty; Mitral Valve Insufficiency; Platelet Aggregation Inhibitors; Recurrence; Rivaroxaban; Thrombectomy; Thrombosis; Treatment Outcome | 2020 |
Intensified P2Y12 inhibition for high-on treatment platelet reactivity.
Topics: Aged; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Retrospective Studies; Thrombosis; Ticagrelor | 2020 |
Diffuse saphenous vein graft thrombosis: resolution after one month of apixaban and dual antiplatelet therapy.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Graft Occlusion, Vascular; Humans; Male; Non-ST Elevated Myocardial Infarction; Platelet Aggregation Inhibitors; Pyrazoles; Pyridones; Saphenous Vein; Thrombosis; Treatment Outcome | 2020 |
Ischemic Versus Bleeding Outcomes After Percutaneous Coronary Interventions in Patients With High Bleeding Risk.
Topics: Aged; Aspirin; Cause of Death; Clopidogrel; Comorbidity; Coronary Artery Disease; Dual Anti-Platelet Therapy; Female; Gastrointestinal Hemorrhage; Heart Failure; Hemorrhage; Humans; Male; Middle Aged; Mortality; Myocardial Infarction; Myocardial Revascularization; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prevalence; Renal Insufficiency; Risk; Risk Assessment; Stents; Thrombosis | 2020 |
Congenital protein C deficiency and thrombosis in a dog.
Topics: Animals; Clopidogrel; Dog Diseases; Dogs; Echocardiography; Factor Xa Inhibitors; Male; Platelet Aggregation Inhibitors; Protein C Deficiency; Rivaroxaban; Thrombosis; Tomography, X-Ray Computed | 2020 |
Subacute stent thrombosis in a patient with type 2 diabetes and clopidogrel resistance: A case report
.
Topics: Clopidogrel; Diabetes Mellitus, Type 2; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2020 |
Acute Thrombus Burden on Coated Flow Diverters Assessed by High Frequency Optical Coherence Tomography.
Topics: Acute Disease; Animals; Aspirin; Clopidogrel; Coated Materials, Biocompatible; Disease Models, Animal; Platelet Aggregation Inhibitors; Stents; Swine; Thrombosis; Tomography, Optical Coherence | 2020 |
Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics.
Topics: Aged; Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Exome; Female; Humans; Introns; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Thrombosis | 2021 |
Cap-fitted identification and endoscopic haemostasis of a tiny vascular colonic lesion under maintained triple antithrombotic therapy.
Topics: Aspirin; Blood Transfusion; Clopidogrel; Colonic Diseases; Colonoscopy; Combined Modality Therapy; Drug Therapy, Combination; Endoscopy, Digestive System; Equipment Design; Fibrinolytic Agents; Gastrointestinal Hemorrhage; Hemostatic Techniques; Humans; Ileocecal Valve; Male; Middle Aged; Reoperation; Thrombosis; Warfarin | 2021 |
Thrombosis of a Percutaneous Transcatheter Mitral Valve Implant and Its Treatment.
Topics: Anticoagulants; Bioprosthesis; Cardiac Catheterization; Clopidogrel; Coronary Artery Disease; Echocardiography; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Humans; Male; Middle Aged; Mitral Valve; Mitral Valve Insufficiency; Postoperative Complications; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Pyridones; Thrombosis; Treatment Outcome; Withholding Treatment | 2020 |
Comparison of acetylsalicylic acid and clopidogrel non-responsiveness assessed by light transmittance aggregometry and PFA-100® in patients undergoing neuroendovascular procedures.
Topics: Adenosine Diphosphate; Aged; Alprostadil; Aspirin; Blood Coagulation Tests; Blood Platelets; Clopidogrel; Collagen; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Reproducibility of Results; Stents; Technology Assessment, Biomedical; Thrombosis; Time Factors | 2020 |
Safety and Efficacy of Single Versus Dual Antiplatelet Therapy After Left Atrial Appendage Occlusion.
Topics: Aged; Aged, 80 and over; Aspirin; Atrial Appendage; Atrial Fibrillation; Cardiovascular Diseases; Clopidogrel; Dual Anti-Platelet Therapy; Embolism; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prosthesis Implantation; Septal Occluder Device; Stroke; Thrombosis | 2020 |
Impact of the CYP2C19*17 Allele on Outcomes in Patients Receiving Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Genotype; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenetics; Pharmacogenomic Testing; Pharmacogenomic Variants; Phenotype; Platelet Aggregation Inhibitors; Precision Medicine; Risk Assessment; Risk Factors; Thrombosis; Time Factors; Treatment Outcome; United States | 2021 |
Desmopressin with four-factor prothrombin complex concentrate for life-threatening bleeding: A case series.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Blood Coagulation Factors; Cerebral Hemorrhage, Traumatic; Cerebral Intraventricular Hemorrhage; Clopidogrel; Deamino Arginine Vasopressin; Female; Fractures, Bone; Hematoma; Hematoma, Subdural, Intracranial; Hemostatics; Humans; International Normalized Ratio; Intracranial Hemorrhage, Traumatic; Male; Middle Aged; Pelvic Bones; Platelet Aggregation Inhibitors; Pyrazoles; Pyridones; Retrospective Studies; Rivaroxaban; Subarachnoid Hemorrhage, Traumatic; Thrombosis; Warfarin | 2020 |
Effect of Continued Perioperative Anticoagulant Therapy on Bleeding Outcomes Following Robot-assisted Radical Prostatectomy.
Topics: Aged; Anticoagulants; Antithrombins; Aspirin; Blood Transfusion; Clopidogrel; Continuity of Patient Care; Humans; Incidence; Male; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prasugrel Hydrochloride; Prostatectomy; Prostatic Neoplasms; Retrospective Studies; Robotic Surgical Procedures; Thrombosis; Warfarin | 2021 |
Comparison of Warfarin to Dual Antiplatelet Therapy Following Transcatheter Aortic Valve Replacement.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Thrombosis; Transcatheter Aortic Valve Replacement; Warfarin | 2021 |
Late Stent Thrombosis After Drug-Coated Balloon Coronary Angioplasty for In-Stent Restenosis.
Topics: Acute Disease; Adult; Aftercare; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Occlusion; Coronary Restenosis; Cytochrome P-450 CYP2C19; Dual Anti-Platelet Therapy; Female; Fibrinolytic Agents; Humans; Integrin alpha2; Mutation; Myocardial Infarction; Purinergic P2Y Receptor Antagonists; Stents; Thrombectomy; Thrombosis; Ticagrelor; Tirofiban; Treatment Outcome | 2021 |
The effect of ticagrelor on microarterial thrombosis in an experimental model.
Topics: Adenosine; Animals; Clopidogrel; Models, Theoretical; Platelet Aggregation Inhibitors; Rats; Thrombosis; Ticagrelor; Ticlopidine | 2021 |
Successful Therapy With Ticagrelor in Three-Vessel Stent Thrombosis Related to Clopidogrel Resistance.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Dual Anti-Platelet Therapy; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticagrelor | 2021 |
Long-term Outcomes of Clopidogrel Monotherapy versus Prolonged Dual Antiplatelet Therapy beyond 12 Months after Percutaneous Coronary Intervention in High-risk Patients.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Republic of Korea; Stroke; Thrombosis; Treatment Outcome | 2021 |
Platelet Function Monitoring Performed after Carotid Stenting during Endovascular Stroke Treatment Predicts Outcome.
Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Databases, Factual; Disability Evaluation; Drug Monitoring; Endovascular Procedures; Female; Humans; Intracranial Hemorrhages; Ischemic Stroke; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Stents; Thrombosis; Time Factors; Treatment Outcome | 2021 |
Free-floating and spinning thrombus of the basilar artery: A case report.
Topics: Angiography, Digital Subtraction; Basilar Artery; Cerebellum; Cerebral Angiography; Cerebral Infarction; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Pons; Thrombosis; Treatment Outcome; Vertebrobasilar Insufficiency; Warfarin | 2021 |
Incidence of Device-Related Thrombosis in Watchman Patients Undergoing a Genotype-Guided Antithrombotic Strategy.
Topics: Clopidogrel; Fibrinolytic Agents; Genotype; Humans; Incidence; Thrombosis | 2021 |
Administration of Ticagrelor and Double-Dose Clopidogrel Based on Platelet Reactivity Determined by VerifyNow-P2Y12 for Chinese Subjects After Elective PCI.
Topics: Adenosine; Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Postoperative Complications; Purinergic P2Y Receptor Antagonists; Thrombosis; Ticagrelor; Ticlopidine | 2017 |
Comparison of dual antiplatelet therapy versus oral anticoagulation following transcatheter aortic valve replacement: A retrospective single-center registry analysis.
Topics: Administration, Oral; Aged, 80 and over; Aortic Valve; Aortic Valve Stenosis; Aspirin; Clopidogrel; Drug Therapy, Combination; Echocardiography; Female; Follow-Up Studies; Humans; Male; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Thrombolytic Therapy; Thrombosis; Transcatheter Aortic Valve Replacement; Treatment Outcome | 2017 |
Clopidogrel Load Reduces Emboli in Carotid Artery Stenosis With Free-Floating Thrombus.
Topics: Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Embolism; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Tomography Scanners, X-Ray Computed; Ultrasonography, Doppler, Transcranial | 2017 |
Repetitive stent thrombosis in a patient with suspected allergy to aspirin and multiple switch between clopidogrel, prasugrel, and ticagrelor.
Topics: Adenosine; Aspirin; Clopidogrel; Coronary Vessels; Drug Hypersensitivity; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Recurrence; Stents; Thrombosis; Ticagrelor; Ticlopidine | 2017 |
Platelet transfusion to reverse antiplatelet therapy before decompressive surgery in patients with intracranial haemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Decompression, Surgical; Female; Hemorrhage; Humans; Intracranial Hemorrhages; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Preoperative Care; Stroke; Thrombosis; Ticlopidine | 2017 |
A Novel Multiplex HRM Assay to Detect Clopidogrel Resistance.
Topics: Asian People; Biological Assay; Clopidogrel; Genotype; Genotyping Techniques; Humans; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Thrombosis | 2017 |
Anticoagulation strategies in patients with atrial fibrillation after PCI or with ACS : The end of triple therapy?
Topics: Acute Coronary Syndrome; Administration, Oral; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Guideline Adherence; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Randomized Controlled Trials as Topic; Risk Factors; Stents; Stroke; Thrombosis; Vitamin K | 2018 |
Impact of early (3 months) dual antiplatelet treatment interruption prior to renal transplantation in patients with second-generation DES on perioperative stent thrombosis and MACEs.
Topics: Clopidogrel; Drug Administration Schedule; Drug-Eluting Stents; Everolimus; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Period; Retrospective Studies; Sirolimus; Thrombosis | 2017 |
What is the significance, if any, of the increased incidence of stent thrombosis with dual therapy of dabigatran 110mg twice daily and clopidogrel in the RE-DUAL PCI trial?
Topics: Clopidogrel; Dabigatran; Drug Therapy, Combination; Humans; Incidence; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2018 |
Anti-thrombotic efficacy of S007-867: Pre-clinical evaluation in experimental models of thrombosis in vivo and in vitro.
Topics: Animals; Aspirin; Blood Coagulation; Chlorides; Clopidogrel; Dose-Response Relationship, Drug; Ferric Compounds; Fibrinolytic Agents; Male; Mice; Piperidines; Platelet Adhesiveness; Platelet Aggregation; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thrombosis | 2018 |
Which Antiplatelet Therapy in Patients With Left Ventricular Assist Device and Aspirin Allergy?
Topics: Aspirin; Clopidogrel; Drug Hypersensitivity; Drug Therapy, Combination; Heart Failure; Heart-Assist Devices; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombosis; Ticlopidine; Warfarin | 2018 |
WATCHMAN device-related thrombus successfully treated with apixaban: A case report.
Topics: Aged; Anticoagulants; Aspirin; Atrial Appendage; Atrial Fibrillation; Clopidogrel; Factor Xa Inhibitors; Humans; Male; Prostheses and Implants; Pyrazoles; Pyridones; Thrombosis; Ticlopidine | 2017 |
Acute stent thrombosis after stent-assisted coiling in an intracranial aneurysm patient carrying two reduced-function CYP2C19 alleles: A case report.
Topics: Adult; Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Intracranial Aneurysm; Male; Pharmacogenomic Variants; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2017 |
Comparison of the 9-month intra-stent conditions and 2-year clinical outcomes after Resolute zotarolimus-eluting stent implantation between 3-month and standard dual antiplatelet therapy.
Topics: Aged; Angina Pectoris; Aspirin; Clopidogrel; Coronary Stenosis; Coronary Vessels; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Hemorrhage; Humans; Japan; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Sirolimus; Thrombosis; Tomography, Optical Coherence | 2018 |
Pretreatment with P2Y12 inhibitors and outcome in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
Topics: Aged; Belgium; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Preoperative Care; Purinergic P2Y Receptor Antagonists; ST Elevation Myocardial Infarction; Stents; Survival Analysis; Thrombosis; Ticagrelor; Time Factors; Treatment Outcome | 2018 |
Compression force sensing regulates integrin α
Topics: Adult; Animals; Aspirin; Blood Platelets; Clopidogrel; Diabetes Mellitus, Type 1; Female; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Phosphatidylinositol 3-Kinases; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Ticlopidine | 2018 |
Acute myocardial infarction occurring while on chronic clopidogrel therapy ('clopidogrel failure') is associated with high incidence of clopidogrel poor responsiveness and stent thrombosis.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Thrombosis; Ticlopidine; Treatment Failure | 2018 |
Is a variability of platelet inhibitory effect of anti-platelet agents important for predicting new lesion in atherothrombotic stroke?
Topics: Aged; Aged, 80 and over; Aspirin; Atherosclerosis; Blood Platelets; Clopidogrel; Diffusion Magnetic Resonance Imaging; Female; Fibrinogen; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Thrombosis | 2018 |
Potent effect of prasugrel on acute phase resolution of intra-stent athero-thrombotic burden after percutaneous intervention to acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Postoperative Complications; Prasugrel Hydrochloride; Prospective Studies; Registries; Stents; Thrombosis; Tomography, Optical Coherence; Treatment Outcome | 2018 |
NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Blood Coagulation; Capsules; Carrageenan; Cell Adhesion; Clopidogrel; Disease Models, Animal; Drugs, Chinese Herbal; Endothelium, Vascular; Fibrinolytic Agents; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Liver; Male; Mice, Inbred BALB C; Monocytes; Oxidative Stress; Platelet Aggregation Inhibitors; Powders; Signal Transduction; Tail; THP-1 Cells; Thrombosis | 2018 |
Left ventricular mural thrombus despite treatment with dabigatran and clopidogrel.
Topics: Aged, 80 and over; Anticoagulants; Antithrombins; Atrial Fibrillation; Clopidogrel; Dabigatran; Diagnosis, Differential; Drug Therapy, Combination; Dyspnea; Echocardiography; Fatal Outcome; Heart Diseases; Heart Failure; Humans; Male; Thrombosis; Ticlopidine; Warfarin | 2018 |
Comparison of Ticagrelor with Clopidogrel in Reducing Interleukin-17 and Myeloperoxidase Expression in Thrombus and Improving Postprocedural Coronary Flow in ST-segment Elevation Myocardial Infarction Patients.
Topics: Adolescent; Adult; Aged; Clopidogrel; Coronary Circulation; Female; Humans; Interleukin-17; Middle Aged; Peroxidase; Platelet Aggregation Inhibitors; ST Elevation Myocardial Infarction; Thrombosis; Ticagrelor; Young Adult | 2018 |
Effect of Physical Exercise on Platelet Reactivity in Patients with Dual Antiplatelet Therapy.
Topics: Adenosine Diphosphate; Aspirin; Chromogranin A; Clopidogrel; Coronary Artery Disease; Electrocardiography; Exercise; Exercise Tolerance; Humans; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Count; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thrombosis; Ticlopidine | 2018 |
Clustering of ABCB1 and CYP2C19 Genetic Variants Predicts Risk of Major Bleeding and Thrombotic Events in Elderly Patients with Acute Coronary Syndrome Receiving Dual Antiplatelet Therapy with Aspirin and Clopidogrel.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Alleles; Aspirin; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Hemorrhage; Humans; Male; Phenotype; Pilot Projects; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Risk; Thrombosis | 2018 |
Clopidogrel bisulfate (Plavix) does not increase bleeding complications in patients undergoing rubber band ligation for symptomatic hemorrhoids.
Topics: Aged; Clopidogrel; Female; Hemorrhoids; Humans; Incidence; Ligation; Male; Perioperative Period; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Recurrence; Retrospective Studies; Thrombosis; Treatment Outcome | 2018 |
Late stent thrombosis in a patient with CYP2C19*3/*17 genotype and clopidogrel high on-treatment platelet reactivity.
Topics: Adult; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Genotype; Humans; Male; Platelet Aggregation Inhibitors; Thrombosis; Ticagrelor | 2018 |
Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H
Topics: Activation, Metabolic; Animals; Clopidogrel; Disulfides; Humans; Hydrogen Sulfide; Male; Metabolome; Mice, Inbred C57BL; Models, Biological; Thrombosis | 2018 |
The Role of OCT Guidance for Antiplatelet Therapy.
Topics: Aspirin; Clopidogrel; Humans; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Thrombosis; Ticagrelor; Tomography, Optical Coherence | 2018 |
Preventing arteriovenous shunt failure in hemodialysis patients: a population-based cohort study.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arteriovenous Shunt, Surgical; Aspirin; Aspirin, Dipyridamole Drug Combination; Blood Vessel Prosthesis Implantation; Clopidogrel; Databases, Factual; Female; Gastrointestinal Hemorrhage; Graft Occlusion, Vascular; Humans; Intracranial Hemorrhages; Kidney Failure, Chronic; Male; Middle Aged; Platelet Aggregation Inhibitors; Protective Factors; Renal Dialysis; Retrospective Studies; Risk Assessment; Risk Factors; Taiwan; Thrombosis; Treatment Failure; Warfarin; Young Adult | 2019 |
Effect of P2Y
Topics: Adenosine Monophosphate; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Fibrin Clot Lysis Time; Fibrinolysis; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Thrombosis; Ticagrelor | 2019 |
Prevalence of pharmacogenomic variants affecting the efficacy of clopidogrel therapy in the Hispanic Community Health Study/Study of Latinos cohort.
Topics: Acute Coronary Syndrome; Aged; Aryldialkylphosphatase; ATP Binding Cassette Transporter, Subfamily B; Carboxylic Ester Hydrolases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Galactosyltransferases; Gene Frequency; Genotype; Hispanic or Latino; Humans; Male; Middle Aged; Myocardial Infarction; Pharmacogenomic Variants; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Stents; Thrombosis | 2019 |
Impact of Clopidogrel Loading for Coronarography on Bleeding After Urgent First Time CABG.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Retrospective Studies; Thrombosis; Treatment Outcome | 2018 |
Comparing the vascular thromboembolic events following arteriovenous fistula in Chinese population with end-stage renal diseases receiving Clopidogrel versus Beraprost sodium therapy: a retrospective cohort study.
Topics: Adult; Aged; Arteriovenous Shunt, Surgical; China; Clopidogrel; Constriction, Pathologic; Epoprostenol; Female; Hemorrhage; Humans; Incidence; Kidney Failure, Chronic; Male; Middle Aged; Platelet Aggregation Inhibitors; Renal Dialysis; Retrospective Studies; Thrombosis; Time Factors; Young Adult | 2018 |
Utility of Dual Antiplatelet Therapy for the Prevention of Subclinical Leaflet Thrombosis: Now Is Not the Time to HALT the Use of Dual Antiplatelet Therapy.
Topics: Clopidogrel; Humans; Incidence; Platelet Aggregation Inhibitors; Thrombosis; Transcatheter Aortic Valve Replacement; Treatment Outcome | 2019 |
Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Endoscopic Mucosal Resection; Feasibility Studies; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Practice Guidelines as Topic; Retrospective Studies; Risk Factors; Stomach Neoplasms; Thrombosis; Treatment Outcome | 2019 |
Pretreatment with P2Y12 receptor antagonists in ST-elevation myocardial infarction: a report from the Swedish Coronary Angiography and Angioplasty Registry.
Topics: Aged; Aged, 80 and over; Angioplasty; Clopidogrel; Coronary Angiography; Female; Hemorrhage; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Registries; ST Elevation Myocardial Infarction; Stents; Survival Rate; Sweden; Thrombosis; Ticagrelor | 2019 |
The effect of ticagrelor based dual antiplatelet therapy on development of late left ventricular thrombus after acute anterior ST elevation myocardial infarction.
Topics: Aged; Anterior Wall Myocardial Infarction; Aspirin; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Dual Anti-Platelet Therapy; Echocardiography; Female; Follow-Up Studies; Heart Diseases; Heart Ventricles; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Retrospective Studies; ST Elevation Myocardial Infarction; Thrombosis; Ticagrelor; Treatment Outcome; Turkey | 2019 |
Antithrombotic Activity of a Novel Diazepino[1,2-α] Benzimidazole Derivative on Arterial Thrombosis Model in Rats without Concomitant Pathology and in Rats with Experimental Myocardial Infarction.
Topics: Animals; Animals, Outbred Strains; Aspirin; Azepines; Benzimidazoles; Blood Coagulation Tests; Chlorides; Clopidogrel; Disease Models, Animal; Ferric Compounds; Fibrinolytic Agents; Male; Myocardial Infarction; Platelet Aggregation; Rats; Thrombosis | 2019 |
Replacement of ticagrelor with clopidogrel complicated with acute in‑stent thrombosis.
Topics: Clopidogrel; Coronary Artery Disease; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; ST Elevation Myocardial Infarction; Stents; Thrombosis; Ticagrelor | 2019 |
Left Atrial Thrombus Formation in a Patient With Severe Non-rheumatic Mitral Stenosis After Mitral Valve Repair Receiving Dual Antiplatelet Therapy: A Clinical Challenge.
Topics: Aspirin; Clopidogrel; Female; Heart Atria; Humans; Middle Aged; Mitral Valve Stenosis; Monitoring, Intraoperative; Platelet Aggregation Inhibitors; Severity of Illness Index; Thrombosis | 2019 |
Tailored P2Y
Topics: Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk; Stroke; Thrombosis | 2019 |
Periprocedural prophylactic antithrombotic strategies in interventional radiology: current practice in the Netherlands and comparison with the United kingdom.
Topics: Clopidogrel; Fibrinolytic Agents; Heparin; Humans; Netherlands; Perioperative Care; Practice Patterns, Physicians'; Radiology, Interventional; Stents; Surveys and Questionnaires; Thrombosis; Ticlopidine; United Kingdom; Vascular Surgical Procedures | 2013 |
High-dose aspirin in dogs increases vascular resistance with limited additional anti-platelet effect when combined with potent P2Y12 inhibition.
Topics: Adenosine; Animals; Arachidonic Acid; Aspirin; Clopidogrel; Dogs; Dose-Response Relationship, Drug; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombosis; Ticagrelor; Ticlopidine; Vascular Resistance | 2013 |
Cardiac magnetic resonance detection of left ventricular thrombus in acute myocardial infarction.
Topics: Aged; Anticoagulants; Aspirin; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Echocardiography; Female; Humans; Incidence; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Stroke Volume; Thrombosis; Ticlopidine; Ventricular Dysfunction, Left; Warfarin | 2013 |
The duel between dual antiplatelet therapies.
Topics: Adenosine Monophosphate; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Myocardial Ischemia; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2013 |
CYP2C19 phenotype, stent thrombosis, myocardial infarction, and mortality in patients with coronary stent placement in a Chinese population.
Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Expression; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Postoperative Hemorrhage; Stents; Survival Analysis; Thrombosis; Ticlopidine | 2013 |
Relationship between aspirin/clopidogrel resistance and intra-stent thrombi assessed by follow-up optical coherence tomography after drug-eluting stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cohort Studies; Confidence Intervals; Coronary Angiography; Coronary Thrombosis; Drug Resistance; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Platelet Aggregation Inhibitors; Prosthesis Failure; Retrospective Studies; Risk Assessment; Severity of Illness Index; Thrombosis; Ticlopidine; Tomography, Optical Coherence; Treatment Outcome | 2013 |
Antiplatelet therapy at the time of coronary artery bypass grafting: a multicentre cohort study.
Topics: Aged; Analysis of Variance; Aspirin; Blood Transfusion; Clopidogrel; Cohort Studies; Coronary Artery Bypass; Denmark; Female; Hospitals, University; Humans; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Reoperation; Thrombosis; Ticlopidine | 2013 |
Challenging ticagrelor's claimed reduction in the rate of definite stent thrombosis versus clopidogrel: insights from the FDA reports.
Topics: Adenosine; Clopidogrel; Drug-Eluting Stents; Humans; Randomized Controlled Trials as Topic; Thrombosis; Ticagrelor; Ticlopidine; United States; United States Food and Drug Administration | 2013 |
Combined and independent impact of diabetes mellitus and chronic kidney disease on residual platelet reactivity.
Topics: Aged; Clopidogrel; Diabetes Complications; Diabetes Mellitus; Female; Humans; Kidney Diseases; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Function Tests; Preoperative Care; Prospective Studies; Receptors, Purinergic P2Y12; Risk; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
Perioperative management of a neurosurgical patient with a meningioma and recent coronary artery stent.
Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Contraindications; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Meningioma; Perioperative Care; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2013 |
Long-term safety and efficacy of dual therapy with oral anticoagulation and clopidogrel in patients with atrial fibrillation treated with drug-eluting stents.
Topics: Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Comparison of clinical efficacy and safety of clopidogrel resinate with clopidogrel bisulfate in patients undergoing percutaneous coronary intervention.
Topics: Aged; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
Arterial thrombosis after vehicular trauma and humeral fracture in a dog.
Topics: Accidents, Traffic; Animals; Anticoagulants; Clopidogrel; Dalteparin; Dog Diseases; Dogs; Female; Forelimb; Fracture Fixation, Internal; Fractures, Bone; Heparin; Thrombosis; Ticlopidine | 2013 |
DES thrombosis related to antiplatelet therapy noncompliance: a consequence of the Greek financial crisis.
Topics: Aged, 80 and over; Clopidogrel; Drug-Eluting Stents; Economic Recession; Greece; Humans; Male; Medication Adherence; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2013 |
Antiplatelet and anticoagulation therapy in microlaryngeal surgery.
Topics: Adult; Aged; Aspirin; Clopidogrel; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Incidence; Laryngeal Diseases; Laryngectomy; Laryngoplasty; Male; Microsurgery; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Period; Retrospective Studies; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome; United States | 2014 |
A comparative study of bivalirudin plus clopidogrel versus bivalirudin plus prasugrel in primary angioplasty using propensity score matching.
Topics: Angioplasty; Antithrombins; Clopidogrel; Cohort Studies; Drug Combinations; Female; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Piperazines; Postoperative Complications; Prasugrel Hydrochloride; Recombinant Proteins; Retrospective Studies; Thiophenes; Thrombosis; Ticlopidine | 2013 |
Expert position paper on the role of platelet function testing in patients undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Substitution; Drug Therapy, Combination; Genotype; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Activation; Platelet Function Tests; Practice Guidelines as Topic; Prognosis; Purinergic P2Y Receptor Antagonists; Thrombosis; Ticlopidine | 2014 |
Changes in response to antiaggregatory treatment in patients with myeloproliferative neoplasms: a sequential study using multiple electrode aggregometry.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel; Electrodes; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Myeloproliferative Disorders; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
Clustering of acute and subacute stent thrombosis related to the introduction of generic clopidogrel.
Topics: Acute Disease; Aged; Aged, 80 and over; Clopidogrel; Cluster Analysis; Drug Substitution; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Stents; Thrombosis; Ticlopidine | 2014 |
Disbalance between mortality and non-fatal vascular events in the CHAMPION-PHOENIX trial: the cangrelor efficacy challenge.
Topics: Adenosine Monophosphate; Blood Platelets; Clopidogrel; Data Interpretation, Statistical; Humans; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Randomized Controlled Trials as Topic; Research Design; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence.
Topics: Acrylamides; Animals; Blood Platelets; Clopidogrel; Dinoprostone; Disease Models, Animal; Mice; Plaque, Atherosclerotic; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Prostaglandin E, EP3 Subtype; Sulfones; Thrombosis; Ticlopidine | 2014 |
Thrombotic aortic restenosis after transapical SAPIEN valve implantation.
Topics: Aged, 80 and over; Anticoagulants; Aortic Valve Stenosis; Aspirin; Bioprosthesis; Clopidogrel; Echocardiography, Transesophageal; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Heparin; Humans; Male; Prosthesis Failure; Recurrence; Thrombosis; Ticlopidine; Treatment Outcome | 2014 |
Cigarette smoking and antiplatelet effects of aspirin monotherapy versus clopidogrel monotherapy in patients with atherosclerotic disease: results of a prospective pharmacodynamic study.
Topics: Adult; Aged; Aspirin; Atherosclerosis; Biomarkers; Blood Platelets; Clopidogrel; Cotinine; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Signal Transduction; Smoking; Thrombelastography; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
The role of clinical parameters and of CYP2C19 G681 and CYP4F2 G1347A polymorphisms on platelet reactivity during dual antiplatelet therapy.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Thrombosis; Ticlopidine | 2014 |
Optimizing P2Y12 receptor inhibition in patients with acute coronary syndrome on the basis of platelet function testing: impact of prasugrel and high-dose clopidogrel.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Cause of Death; Clopidogrel; Combined Modality Therapy; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Function Tests; Prasugrel Hydrochloride; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Purinergic P2Y Receptor Antagonists; Registries; Risk Assessment; Severity of Illness Index; Stents; Stroke; Survival Rate; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2014 |
Clopidogrel resistance in diabetic patient with acute myocardial infarction due to stent thrombosis.
Topics: Aged, 80 and over; Aspirin; Clopidogrel; Coronary Angiography; Diabetes Mellitus, Type 2; Drug Resistance; Electrocardiography; Heparin; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thiophenes; Thrombosis; Ticlopidine | 2014 |
Differences in thrombus structure and kinetics in patients with type 2 diabetes mellitus after non ST elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2014 |
HeartWare left ventricular assist device thrombosis in aspirin non-responder.
Topics: Aged; Aspirin; Cardiomyopathy, Dilated; Clopidogrel; Drug Resistance; Drug Substitution; Fibrinolytic Agents; Heart Valve Prosthesis; Humans; International Normalized Ratio; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prosthesis Design; Thrombolytic Therapy; Thrombosis; Ticlopidine; Treatment Outcome; Ventricular Function, Left | 2014 |
Point-of-care testing of clopidogrel-mediated platelet inhibition and risk for cardiovascular events after coronary angiography with or without percutaneous coronary intervention.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Angiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Patient Readmission; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; ROC Curve; Stents; Survival Analysis; Thrombosis; Ticlopidine | 2014 |
Are we there yet? deciding when it is safe (and wise) to stop clopidogrel after stent implantation.
Topics: Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors | 2014 |
A cautionary tale on the use of antiplatelet treatment following TURP.
Topics: Aged; Aspirin; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Hematuria; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombosis; Ticlopidine; Transurethral Resection of Prostate; Urinary Bladder; Urinary Bladder Diseases | 2014 |
Tailoring platelet inhibition according to multiple electrode aggregometry decreases the rate of thrombotic complications after intracranial flow-diverting stent implantation.
Topics: Cerebrovascular Circulation; Clopidogrel; Endovascular Procedures; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine | 2015 |
Impact of early versus late clopidogrel discontinuation on stent thrombosis following percutaneous coronary intervention with first- and second-generation drug-eluting stents.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Combined Modality Therapy; Coronary Angiography; Coronary Stenosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Eluting Stents; Everolimus; Female; Follow-Up Studies; Graft Occlusion, Vascular; Hospital Mortality; Humans; Male; Middle Aged; Paclitaxel; Prosthesis Failure; Registries; Retrospective Studies; Severity of Illness Index; Sirolimus; Survival Analysis; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Withholding Treatment | 2014 |
Pharmacologic strategy for one repeated stent thrombosis patient with hyporesponsiveness to standard dual antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Electrocardiography; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Smoking; Stents; Thrombosis; Ticlopidine | 2015 |
Inhibition of platelet activation prevents the P-selectin and integrin-dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasis in vivo.
Topics: Animals; Blood Coagulation; Blotting, Western; Cell-Derived Microparticles; Clopidogrel; Disease Models, Animal; Flow Cytometry; Fluorescent Antibody Technique; Integrins; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; P-Selectin; Pancreatic Neoplasms; Platelet Activation; Platelet Aggregation Inhibitors; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thromboplastin; Thrombosis; Ticlopidine; Tumor Cells, Cultured | 2015 |
Aortic thrombosis secondary to clopidogrel-related thrombotic thrombocytopenic purpura.
Topics: Aged; Aorta, Abdominal; Aortic Diseases; Clopidogrel; Female; Humans; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Thrombosis; Ticlopidine; Tomography, X-Ray Computed | 2014 |
In-hospital switching between clopidogrel and prasugrel among patients with acute myocardial infarction treated with percutaneous coronary intervention: insights into contemporary practice from the national cardiovascular data registry.
Topics: Acute Disease; Age Factors; Aged; Clopidogrel; Drug Substitution; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Postoperative Complications; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Recurrence; Registries; Risk Factors; Thiophenes; Thrombosis; Ticlopidine; United States | 2014 |
Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk.
Topics: Adenosine Diphosphate; Animals; Apyrase; Clopidogrel; Coronary Circulation; Dogs; Fibrinolysis; Hemorrhage; Humans; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Piperazines; Platelet Aggregation; Prasugrel Hydrochloride; Risk Factors; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Tissue Plasminogen Activator; Treatment Outcome; Vascular Patency | 2014 |
First report of stent thrombosis after a switch therapy resulting from ticagrelor-related dyspnea.
Topics: Adenosine; Aged; Clopidogrel; Drug Substitution; Dyspnea; Humans; Male; Purinergic P2Y Receptor Antagonists; Stents; Thrombosis; Ticagrelor; Ticlopidine | 2014 |
Aspirin treatment and outcomes after percutaneous coronary intervention: results of the ISAR-ASPI registry.
Topics: Aged; Aspirin; Biomarkers; Clopidogrel; Female; Humans; Incidence; Male; Middle Aged; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Proportional Hazards Models; Registries; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Safety and efficacy of in-hospital clopidogrel-to-prasugrel switching in patients with acute coronary syndrome. An analysis from the 'real world'.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Substitution; Female; Hemorrhage; Humans; Male; Middle Aged; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Sex Factors; Thrombosis; Ticlopidine | 2015 |
Influence of race and sex on thrombogenicity in a large cohort of coronary artery disease patients.
Topics: Aged; Aspirin; Cardiac Catheterization; Chi-Square Distribution; Clopidogrel; Cohort Studies; Coronary Angiography; Coronary Artery Disease; Female; Follow-Up Studies; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation; Platelet Function Tests; Racial Groups; Risk Assessment; Sex Factors; Thrombelastography; Thrombosis; Ticlopidine; Treatment Outcome | 2014 |
Dual antiplatelet therapy after drug-eluting stents--how long to treat?
Topics: Aspirin; Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine | 2014 |
Stent thrombosis is the primary cause of ST-segment elevation myocardial infarction following coronary stent implantation: a five year follow-up of the SORT OUT II study.
Topics: Aged; Angina, Stable; Clopidogrel; Cohort Studies; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2014 |
Impact of cytochrome P450 2C19 loss-of-function polymorphism on intra-stent thrombi and lesion outcome after everolimus-eluting stent implantation compared to that after first-generation drug-eluting stent implantation.
Topics: Aged; Clopidogrel; Coronary Angiography; Cytochrome P-450 Enzyme System; Drug-Eluting Stents; Everolimus; Female; Genotype; Humans; Immunosuppressive Agents; Male; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Sirolimus; Thrombosis; Ticlopidine; Tomography, Optical Coherence | 2015 |
Concomitant use of warfarin and ticagrelor as an alternative to triple antithrombotic therapy after an acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Middle Aged; Retrospective Studies; Risk Factors; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome; Warfarin | 2015 |
Balancing the risks of bleeding and stent thrombosis: a decision analytic model to compare durations of dual antiplatelet therapy after drug-eluting stents.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Decision Support Techniques; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Markov Chains; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Adjustment; Risk Assessment; Thrombosis; Ticlopidine; Time; Treatment Outcome | 2015 |
How should I treat subacute stent thrombosis in the context of brain haemorrhage with abciximab?
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Cerebral Hemorrhage; Clopidogrel; Embolic Protection Devices; Female; Humans; Immunoglobulin Fab Fragments; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stents; Suction; Thrombosis; Ticlopidine | 2015 |
Effect of clinical factors and gene polymorphism of CYP2C19*2, *17 and CYP4F2*3 on early stent thrombosis.
Topics: Aged; Aspirin; Case-Control Studies; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Female; Genotype; Humans; Logistic Models; Male; Middle Aged; Models, Genetic; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Stents; Thrombosis; Ticlopidine | 2015 |
Prognostic impact of clopidogrel pretreatment in patients with acute coronary syndrome managed invasively.
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Percutaneous Coronary Intervention; Preoperative Care; Prognosis; Purinergic P2Y Receptor Antagonists; Registries; Retrospective Studies; Spain; Thrombosis; Ticlopidine; Treatment Outcome | 2015 |
Clinical impact of dual antiplatelet therapy use in patients following everolimus-eluting stent implantation: insights from the SEEDS study.
Topics: Adolescent; Adult; Aged; Aspirin; Clopidogrel; Drug-Eluting Stents; Everolimus; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Sirolimus; Thrombosis; Ticlopidine; Treatment Outcome; Young Adult | 2015 |
Impact of cytochrome P450 2C19*2 polymorphism on intra-stent thrombus assessed by follow-up optical coherence tomography in Chinese patients receiving clopidogrel.
Topics: Aged; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Retrospective Studies; Stents; Thrombosis; Ticlopidine; Tomography, Optical Coherence | 2015 |
[Synergistic action of Compound Danshen Dripping Pill (CDDP) on Clopidogrel Bisulfate (CPG) counteracting platelet aggregation].
Topics: Animals; Bleeding Time; Blood Coagulation; Blood Coagulation Tests; Clopidogrel; Drugs, Chinese Herbal; Hemostatics; Partial Thromboplastin Time; Platelet Aggregation; Platelet Aggregation Inhibitors; Prothrombin Time; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Thrombin Time; Thrombosis; Ticlopidine | 2014 |
In-hospital switching from clopidogrel to prasugrel following thrombolysis for ST-elevation myocardial infarction: a 3-year single center experience.
Topics: Aged; Clopidogrel; Female; Hospitalization; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; ST Elevation Myocardial Infarction; Tertiary Healthcare; Thrombosis; Ticlopidine | 2016 |
Analysis of the Interaction between Clopidogrel, Aspirin, and Proton Pump Inhibitors Using the FDA Adverse Event Reporting System Database.
Topics: Adverse Drug Reaction Reporting Systems; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Embolism; Female; Gastrointestinal Hemorrhage; Humans; Male; Odds Ratio; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Thrombosis; Ticlopidine; United States; United States Food and Drug Administration | 2015 |
Management and outcome of major bleeding in patients on triple therapy after coronary stenting. Clues from the WARfarin and coronary STENTing (WAR-STENT) registry.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Registries; Stents; Thrombosis; Ticlopidine; Treatment Outcome; Warfarin | 2015 |
Financial Analysis of CYP2C19 Genotyping in Patients Receiving Dual Antiplatelet Therapy Following Acute Coronary Syndrome and Percutaneous Coronary Intervention.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Genetic Testing; Genotype; Humans; Managed Care Programs; Models, Economic; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thrombosis; Ticagrelor; Ticlopidine | 2015 |
[The ISAR-SAFE study].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Disease; Coronary Restenosis; Drug Administration Schedule; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Research Design; Risk; Thrombosis; Ticlopidine | 2015 |
Antithrombotic drugs and subarachnoid haemorrhage risk. A nationwide case-control study in Denmark.
Topics: Aged; Aspirin; Case-Control Studies; Clopidogrel; Denmark; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Neurosurgical Procedures; Postoperative Complications; Risk; Subarachnoid Hemorrhage; Thrombosis; Ticlopidine; Vitamin K | 2015 |
Platelet reactivity in MitraClip patients.
Topics: Aspirin; Clopidogrel; Cohort Studies; Heart Valve Prosthesis Implantation; Hemorrhage; Ischemia; Mitral Valve Insufficiency; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2016 |
A complementary role for tetraspanin superfamily member CD151 and ADP purinergic P2Y12 receptor in platelets.
Topics: Animals; Blood Platelets; Cells, Cultured; Clopidogrel; Clot Retraction; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Receptors, Purinergic P2Y12; Tetraspanin 24; Tetraspanins; Thrombosis; Ticlopidine | 2015 |
Predictors of high on-clopidogrel platelet reactivity in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Area Under Curve; Blood Platelets; C-Reactive Protein; Clopidogrel; Coronary Angiography; Logistic Models; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Risk Factors; Smoking; Thrombosis; Ticlopidine; Treatment Outcome | 2016 |
Independent Predictors of Major Adverse Events following Coronary Stenting over 28 Months of Follow-Up.
Topics: Acute Coronary Syndrome; Adult; Aged; Aspirin; Case-Control Studies; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Echocardiography; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Plasminogen Activator Inhibitor 1; Postoperative Complications; Prospective Studies; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome; von Willebrand Factor | 2015 |
Impact of residual platelet reactivity under clopidogrel treatment for lesions and the clinical outcome after drug-eluting stent implantation in patients with hemodialysis.
Topics: Aged; Angina, Stable; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Renal Dialysis; Thrombosis; Ticlopidine; Tomography, Optical Coherence | 2016 |
Optical coherence tomography analysis of the stent strut and prediction of resolved strut malapposition at 3 months after 2nd-generation drug-eluting stent implantation.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Vessels; Drug-Eluting Stents; Everolimus; Female; Humans; Japan; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Design; Sirolimus; Thrombosis; Ticlopidine; Tomography, Optical Coherence | 2016 |
Low platelet activity predicts 30 days mortality in patients undergoing heart surgery.
Topics: Adenosine Diphosphate; Aged; Aortic Valve; Arachidonic Acid; Area Under Curve; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Erythrocyte Transfusion; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Retrospective Studies; Risk Factors; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome | 2016 |
Early hypoattenuated leaflet thickening and restricted leaflet motion of a Lotus transcatheter heart valve detected by 4D computed tomography angiography.
Topics: Aged, 80 and over; Anticoagulants; Aortic Valve Stenosis; Clopidogrel; Coronary Angiography; Female; Four-Dimensional Computed Tomography; Heart Valve Prosthesis; Humans; Phenprocoumon; Platelet Aggregation Inhibitors; Prosthesis Failure; Thrombosis; Ticlopidine; Transcatheter Aortic Valve Replacement | 2015 |
Prior chronic clopidogrel therapy is associated with increased adverse events and early stent thrombosis.
Topics: Acute Coronary Syndrome; Aged; Cardiovascular Diseases; Clopidogrel; Comorbidity; Coronary Artery Bypass; Female; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Stents; Stroke; Surveys and Questionnaires; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Advanced age and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor.
Topics: Adenosine; Adenosine Diphosphate; Age Factors; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Odds Ratio; Patient Discharge; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prevalence; Thrombosis; Ticagrelor; Ticlopidine; Time Factors | 2016 |
Endoscopic ultrasound-guided fine-needle aspiration of solid lesions on clopidogrel may not be a high-risk procedure for bleeding: A case series.
Topics: Aged; Clopidogrel; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Endoscopy, Gastrointestinal; Endosonography; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Thrombosis; Ticlopidine | 2016 |
Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice.
Topics: Adenocarcinoma; Animals; Blood Platelets; Cell Line, Tumor; Cell-Derived Microparticles; Clopidogrel; Female; Flow Cytometry; Humans; Mice; Mice, Inbred C57BL; Neoplasms; Pancreatic Neoplasms; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Thrombin; Thromboplastin; Thrombosis; Ticlopidine | 2016 |
4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in
Topics: Animals; Carboxylic Acids; Clopidogrel; Dogs; Drug Discovery; Esterification; Humans; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Purinergic P2Y Receptor Antagonists; Pyrrolidines; Rats; Rats, Wistar; Thrombosis; Ticlopidine | 2015 |
It Is Not Mandatory to Use Triple Rather Than Dual Anti-Platelet Therapy After a Percutaneous Coronary Intervention With a Second-Generation Drug-Eluting Stent.
Topics: Adult; Aged; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Everolimus; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Complications; Registries; Sirolimus; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2015 |
Percutaneous left atrial appendage occlusion: Device thrombosis in clopidogrel non-responders.
Topics: Aged; Aged, 80 and over; Atrial Appendage; Atrial Fibrillation; Clopidogrel; Female; Heart Diseases; Humans; Male; Middle Aged; Prosthesis Implantation; Thrombosis; Ticlopidine; Treatment Outcome; Ultrasonography | 2016 |
Assessment of platelet-derived thrombogenicity with the total thrombus-formation analysis system in coronary artery disease patients receiving antiplatelet therapy.
Topics: Aged; Area Under Curve; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cross-Sectional Studies; Cytochrome P-450 CYP2C19; Electrocardiography; Female; Genotype; Humans; Male; Middle Aged; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Thrombosis; Ticlopidine | 2016 |
Usefulness of Intravascular Ultrasound for Predicting Risk of Intraprocedural Stent Thrombosis.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Humans; Japan; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Sensitivity and Specificity; Stents; Thrombosis; Ticlopidine; Ultrasonography, Interventional | 2016 |
Effects of genetic factors to stent thrombosis due to clopidogrel resistance after coronary stent placement.
Topics: Blood Platelets; Case-Control Studies; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Genotype; Humans; Male; Middle Aged; Mutation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2016 |
Comparison of Three Tests to Distinguish Platelet Reactivity in Patients with Renal Impairment during Dual Antiplatelet Therapy.
Topics: Aged; Aspirin; Clopidogrel; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Hemorrhage; Humans; Kidney Diseases; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Thrombosis; Ticlopidine | 2016 |
Standardization of a well-controlled in vivo mouse model of thrombus formation induced by mechanical injury.
Topics: Animals; Aorta; Clopidogrel; Disease Models, Animal; Endothelium, Vascular; Eptifibatide; Hirudin Therapy; Male; Mice; Mice, Inbred C57BL; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stress, Mechanical; Thrombosis; Ticlopidine | 2016 |
Hyper-Response to Clopidogrel in Japanese Patients Undergoing Transcatheter Aortic Valve Implantation.
Topics: Aged, 80 and over; Aortic Valve Stenosis; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Genotype; Humans; Japan; Male; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Postoperative Complications; Prognosis; Prospective Studies; Thrombosis; Ticlopidine; Transcatheter Aortic Valve Replacement | 2016 |
Pharmacogenetics of Clopidogrel: An Unresolved Issue.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Electrocardiography; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Pharmacogenetics; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2016 |
A State Transition Model for Health Outcomes Associated with Vorapaxar Treatment as an Add-on to Standard Care Antiplatelet Therapy in the Prevention of Thrombotic Events for Patients with a Recent Myocardial Infarction.
Topics: Aspirin; Cardiovascular System; Clopidogrel; Hemorrhage; Humans; Lactones; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyridines; Secondary Prevention; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2016 |
Incidence and Clinical Features of Early Stent Thrombosis in the Era of New P2y12 Inhibitors (PLATIS-2).
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Clopidogrel; Early Diagnosis; Female; Humans; Israel; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; Stents; Stroke; Survival Analysis; Thrombosis; Ticagrelor; Ticlopidine | 2016 |
Measurement of residual platelet thrombogenicity under arterial shear conditions in cerebrovascular disease patients receiving antiplatelet therapy.
Topics: Adult; Aged; Arteries; Aspirin; Blood Coagulation Tests; Blood Platelets; Carotid Arteries; Cell Adhesion Molecules; Cerebrovascular Circulation; Cerebrovascular Disorders; Clopidogrel; Constriction, Pathologic; Cross-Sectional Studies; Female; Humans; Male; Microfilament Proteins; Middle Aged; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Shear Strength; Thrombosis; Ticlopidine; Vasodilator Agents; Young Adult | 2016 |
Ticagrelor for left ventricular assist device thrombosis: A new therapeutic option to be evaluated with caution.
Topics: Adenosine; Aged; Aspirin; Blood Coagulation; Cardiomyopathies; Clopidogrel; Drug Substitution; Drug Therapy, Combination; Fibrinolytic Agents; Heart-Assist Devices; Humans; Male; Medication Therapy Management; Postoperative Complications; Risk Adjustment; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Locked Away: Percutaneous Closure of a Malignant Left Atrial Appendage to Constrain an Unresolvable Thrombus.
Topics: Aged; Aspirin; Atrial Appendage; Atrial Fibrillation; Catheter Ablation; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Echocardiography, Transesophageal; Factor Xa Inhibitors; Humans; Male; Platelet Aggregation Inhibitors; Rivaroxaban; Septal Occluder Device; Thrombosis; Ticlopidine; Vitamin K | 2016 |
Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis.
Topics: Animals; Arteries; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Mice; Mice, Inbred C57BL; Platelet Aggregation; Pyridines; Rabbits; Thrombosis; Ticlopidine | 2016 |
Platelet Activation and Clopidogrel Effects on ADP-Induced Platelet Activation in Cats with or without the A31P Mutation in MYBPC3.
Topics: Adenosine Diphosphate; Animals; Carrier Proteins; Cat Diseases; Cats; Clopidogrel; Gene Expression Regulation; Genetic Predisposition to Disease; Genotype; Mutation; Platelet Activation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2016 |
Left ventricular non-compaction cardiomyopathy: Incidental diagnosis after ST-elevation myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiomyopathy, Hypertrophic, Familial; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Echocardiography, Doppler, Color; Electrocardiography; Female; Hematologic Agents; Humans; Incidental Findings; ST Elevation Myocardial Infarction; Thrombosis; Ticlopidine; Treatment Outcome; Warfarin | 2016 |
Obesity, leptin, and thrombosis: Focus on clopidogrel resistance.
Topics: Animals; Biomedical Research; Clopidogrel; Drug Resistance; Humans; Leptin; Mice; Obesity; Thrombosis; Ticlopidine | 2016 |
In-stent thrombosis when switching ticagrelor to clopidogrel after percutaneous coronary intervention.
Topics: Adenosine; Blood Platelets; Clopidogrel; Drug Administration Schedule; Drug Dosage Calculations; Drug Substitution; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Purinergic P2Y Receptor Antagonists; ST Elevation Myocardial Infarction; Stents; Thrombosis; Ticagrelor; Ticlopidine | 2017 |
Platelet aggregation and risk of stent thrombosis or bleeding in interventionally treated diabetic patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Diabetes Mellitus; Female; Follow-Up Studies; Graft Occlusion, Vascular; Hemorrhage; Humans; Incidence; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Poland; Prospective Studies; Thrombosis; Ticlopidine | 2016 |
Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression.
Topics: Adenosine; Animals; Blood Coagulation; Blood Platelets; Carotid Artery Injuries; Cells, Cultured; Clopidogrel; Disease Models, Animal; Down-Regulation; Endothelial Cells; Equilibrative Nucleoside Transporter 1; Fibrinolytic Agents; Humans; Male; Mice, Inbred C57BL; Platelet Aggregation Inhibitors; Proteasome Endopeptidase Complex; Proteolysis; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thromboplastin; Thrombosis; Ticagrelor; Ticlopidine; Time Factors; Tumor Necrosis Factor-alpha | 2017 |
Pump Thrombosis following HeartMate II Left Ventricular Assist Device Implantation in a Patient with Aspirin and Plavix Resistance.
Topics: Aged; Aspirin; Clopidogrel; Drug Resistance; Heart Failure; Heart-Assist Devices; Humans; Male; Platelet Aggregation Inhibitors; Prosthesis Failure; Retrospective Studies; Thrombosis; Ticlopidine | 2016 |
Percutaneous left atrial appendage closure followed by single antiplatelet therapy: Short- and mid-term outcomes.
Topics: Aged; Aged, 80 and over; Aspirin; Atrial Appendage; Atrial Fibrillation; Cardiac Catheterization; Clopidogrel; Drug Administration Schedule; Female; France; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Stroke; Thrombosis; Ticlopidine; Time Factors; Tomography, X-Ray Computed; Treatment Outcome | 2017 |
Additive antithrombotic effect of ASP6537, a selective cyclooxygenase (COX)-1 inhibitor, in combination with clopidogrel in guinea pigs.
Topics: Administration, Oral; Animals; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Synergism; Fibrinolytic Agents; Guinea Pigs; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Triazoles | 2017 |
Risk Factors of Subacute Thrombosis After Intracranial Stenting for Symptomatic Intracranial Arterial Stenosis.
Topics: Adult; Aged; Aspirin; Clopidogrel; Constriction, Pathologic; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2017 |
The CYP2C19*2 and CYP2C19*17 Polymorphisms play a Vital Role in Clopidogrel Responsiveness after Percutaneous Coronary Intervention: A Pharmacogenomics Study.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Postoperative Complications; Sequence Analysis, DNA; Stents; Thrombosis; Ticlopidine; Treatment Outcome; Turkey | 2017 |
The effect of correcting VerifyNow P2Y12 assay results for hematocrit in patients undergoing percutaneous coronary interventions.
Topics: Aged; Area Under Curve; Blood Platelets; Clopidogrel; Female; Follow-Up Studies; Hematocrit; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Receptors, Purinergic P2Y12; Risk; ROC Curve; Sensitivity and Specificity; Thrombosis; Ticlopidine | 2017 |
Reversible thrombotic mitral valve stenosis after transcatheter mitral valve replacement (TMVR): Is life-long anticoagulation therapy necessary?
Topics: Aged; Anticoagulants; Aspirin; Bioprosthesis; Cardiac Catheterization; Clopidogrel; Female; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Humans; Mitral Valve; Mitral Valve Stenosis; Postoperative Complications; Thrombosis; Ticlopidine; Treatment Outcome; Warfarin | 2017 |
Improved Pig Model to Evaluate Heart Valve Thrombosis.
Topics: Animals; Aspirin; Blood Coagulation; Blood Platelets; Clopidogrel; Disease Models, Animal; Heart Valve Diseases; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Swine; Thrombosis; Ticlopidine | 2016 |
Effect of Clopidogrel on Thrombus Formation in an Ex Vivo Parallel Plate Flow Chamber Model Cannot Be Reversed by Addition of Platelet Concentrates or vWF Concentrate.
Topics: Anticoagulants; Blood Coagulation; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Humans; Perfusion; Platelet Aggregation Inhibitors; Protein Array Analysis; Thrombosis; Ticlopidine; Treatment Outcome; von Willebrand Factor | 2017 |
Determinants of high on-treatment platelet reactivity and agreement between VerifyNow and Multiplate assays.
Topics: Aged; Aged, 80 and over; Angioplasty; ATP Binding Cassette Transporter, Subfamily B; Biological Assay; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug-Eluting Stents; Female; Gene Expression; Hematocrit; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Polymorphism, Genetic; Thrombosis; Ticlopidine | 2017 |
State transition model: vorapaxar added to standard antiplatelet therapy to prevent thrombosis post myocardial infarction or peripheral artery disease.
Topics: Aspirin; Clopidogrel; Female; Hemorrhage; Humans; Lactones; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Pyridines; Quality of Life; Quality-Adjusted Life Years; Secondary Prevention; Stroke; Thrombosis; Ticlopidine | 2017 |
Antiaggregant and anticoagulant therapy of free-floating thrombus in left atrium.
Topics: Adult; Anticoagulants; Aspirin; Clopidogrel; Diagnosis, Differential; Dyspnea; Echocardiography, Transesophageal; Female; Heart Atria; Heart Diseases; Heparin; Humans; Platelet Aggregation Inhibitors; Radiography; Thrombosis; Ticlopidine; Warfarin | 2008 |
Comparison of stent thrombosis, myocardial infarction, and mortality following drug-eluting versus bare-metal stent coronary intervention in patients with diabetes mellitus.
Topics: Aged; Aspirin; Clopidogrel; Denmark; Diabetes Complications; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Antiplatelet therapy for patients with stents.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine | 2008 |
Incidence and causes of new-onset dyspnea in 3,719 patients treated with clopidogrel and aspirin combination after coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Dyspnea; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Registries; Risk Factors; Stents; Surveys and Questionnaires; Thrombosis; Ticlopidine | 2008 |
Effect of clopidogrel on arteriovenous fistulas for dialysis.
Topics: Arteriovenous Shunt, Surgical; Clopidogrel; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Renal Dialysis; Thrombosis; Ticlopidine | 2008 |
Effect of clopidogrel on arteriovenous fistulas for dialysis.
Topics: Arteriovenous Shunt, Surgical; Clopidogrel; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Renal Dialysis; Thrombosis; Ticlopidine | 2008 |
Repeated high doses of clopidogrel in 2 cases of pharmacological resistance.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Drug Administration Schedule; Drug Resistance; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine; Treatment Failure | 2008 |
[Thrombocyte aggregation inhibitor after surgery for an abdominal aortic aneurysm].
Topics: Aortic Aneurysm, Abdominal; Arteriosclerosis; Aspirin; Blood Vessel Prosthesis Implantation; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Care; Risk Factors; Thrombosis; Ticlopidine | 2008 |
Pro: 'Antithrombotic therapy with warfarin, aspirin and clopidogrel is the recommended regime in anticoagulated patients who present with an acute coronary syndrome and/or undergo percutaneous coronary interventions'.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Thrombosis; Ticlopidine; Warfarin | 2008 |
Contra: 'Antithrombotic therapy with warfarin, aspirin and clopidogrel is the recommended regimen in anticoagulated patients who present with an acute coronary syndrome and/or undergo percutaneous coronary interventions'. Not for everybody.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Thrombosis; Ticlopidine; Warfarin | 2008 |
Clopidogrel under scrutiny.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Research Design; Risk Assessment; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Comparison between ticlopidine and clopidogrel in patients undergoing primary stenting in acute myocardial infarction: results from the CADILLAC trial.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Europe; Female; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Assessment; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; United States | 2008 |
[Management of a high risk of thrombosis patient with drug-eluting stents undergoing a complete gastrectomy].
Topics: Aged; Clopidogrel; Drug-Eluting Stents; Gastrectomy; Humans; Male; Monitoring, Physiologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Stomach Neoplasms; Thrombosis; Ticlopidine | 2009 |
Cytochrome p-450 polymorphisms and response to clopidogrel.
Topics: Acute Coronary Syndrome; Adult; Angioplasty, Balloon, Coronary; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Combined Modality Therapy; Cytochrome P-450 CYP2C19; Female; Genotype; Heterozygote; Humans; Male; Mutation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine | 2009 |
Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Binding, Competitive; Bleeding Time; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hemorrhage; Hemostasis; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rabbits; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Thiophenes; Thrombosis; Ticlopidine | 2009 |
Predicting thrombotic events: creating a complex approach for a complex condition.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Reproducibility of Results; Risk Assessment; Risk Factors; ROC Curve; Thrombosis; Ticlopidine | 2008 |
Cost-effectiveness of drug-eluting stents including the economic impact of late stent thrombosis.
Topics: Aged; Clopidogrel; Cost-Benefit Analysis; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Thrombosis; Ticlopidine | 2009 |
Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding.
Topics: Acrylamides; Animals; Clopidogrel; Dinoprostone; Female; Hemorrhage; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Antagonists; Purinergic P2 Receptor Antagonists; Rats; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Purinergic P2Y12; Sulfones; Thrombosis; Ticlopidine | 2009 |
[Bleeding or stent thrombosis in combination with drug-eluting stents].
Topics: Aneurysm, False; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Drug-Eluting Stents; Fatal Outcome; Groin; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Factors; Thrombosis; Ticlopidine | 2009 |
Athero-embolic isolated splenic infarction following left cardiac catheterization.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aortic Aneurysm, Abdominal; Aspirin; Atherosclerosis; Cardiac Catheterization; Clopidogrel; Coronary Stenosis; Embolism, Cholesterol; Heparin; Humans; Infarction; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Spleen; Thrombosis; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome; Warfarin | 2009 |
Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Electric Impedance; Electrodes; Female; Humans; Kaplan-Meier Estimate; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Prospective Studies; Thrombosis; Ticlopidine | 2009 |
Point-of-care platelet function analysis ready for prime time?
Topics: Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Hemorrhage; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Thrombosis; Ticlopidine | 2009 |
Summaries for patients. What aspirin dose is safest and most effective for preventing heart disease?
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Primary Prevention; Risk Factors; Thrombosis; Ticlopidine | 2009 |
Summaries for patients. Aspirin for the prevention of cardiovascular disease: U.S. Preventive Services Task Force recommendation statement.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Primary Prevention; Risk Factors; Thrombosis; Ticlopidine | 2009 |
Aspirin to prevent cardiovascular disease: the association of aspirin dose and clopidogrel with thrombosis and bleeding.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Observation; Platelet Aggregation Inhibitors; Primary Prevention; Prospective Studies; Randomized Controlled Trials as Topic; Risk Factors; Thrombosis; Ticlopidine | 2009 |
A survey of the peri-operative management of urological patients on clopidogrel.
Topics: Anesthesia; Clopidogrel; Elective Surgical Procedures; Humans; Intraoperative Care; Medical Staff, Hospital; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Professional Practice; Risk Factors; Surveys and Questionnaires; Thrombosis; Ticlopidine; Urologic Diseases; Urology | 2009 |
Update on dual antiplatelet therapy for percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Pyridines; Stents; Thrombosis; Ticlopidine | 2009 |
Incidence of stent thrombosis in patients with drug eluting stents and short-term dual antiplatelet therapy.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Artery Disease; Databases as Topic; Drug Administration Schedule; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Incidence; Kaplan-Meier Estimate; Male; Medication Adherence; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Evidence guided antiplatelet treatment: time to move from bench to bedside.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiology; Cardiovascular Diseases; Clopidogrel; Drug Therapy; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2009 |
A very late stent thrombosis in a patient with diabetes: a call for lifelong dual anti-platelet therapy.
Topics: Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Thrombosis; Ticlopidine; Time Factors | 2009 |
Stent thrombosis, clinical events, and influence of prolonged clopidogrel use after placement of drug-eluting stent data from an observational cohort study of drug-eluting versus bare-metal stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Coronary Artery Disease; Drug Administration Schedule; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Korea; Male; Metals; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prosthesis Design; Risk Assessment; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Searching for the ceiling: new reflections on the disposition and metabolism of clopidogrel.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Genotype; Humans; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stents; Thrombosis; Ticlopidine | 2008 |
The excel stent: a good DES, but can we really stop clopidogrel after 6 months?
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Clopidogrel; Coated Materials, Biocompatible; Coronary Artery Disease; Coronary Restenosis; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Polymers; Prosthesis Design; Risk Assessment; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Proton pump inhibitors and clopidogrel: a difficult dilemma.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Thrombosis; Ticlopidine | 2009 |
Coronary artery disease: Platelet activity: an obstacle for successful PCI.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Patient Selection; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Assessment; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Frequency and outcomes of provisional glycoprotein IIb/IIIa blockade in patients receiving bivalirudin during percutaneous coronary intervention.
Topics: Abciximab; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Embolism; Eptifibatide; Female; Follow-Up Studies; Hirudins; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Peptide Fragments; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Registries; Regression Analysis; Retrospective Studies; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Pharmacy benefit spending poised to increase for antithrombotic drug therapy -- prasugrel versus clopidogrel.
Topics: Clopidogrel; Commerce; Drug Costs; Humans; Insurance, Pharmaceutical Services; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine | 2009 |
The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Synergism; Female; Flow Cytometry; Humans; Imines; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation Inhibitors; Pyridines; Receptor, PAR-1; Thrombosis; Ticlopidine | 2009 |
Obesity and cardiovascular thrombotic events in patients undergoing percutaneous coronary intervention with drug-eluting stents.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Vessel Prosthesis; Body Mass Index; Clopidogrel; Coronary Disease; Death, Sudden, Cardiac; Drug-Eluting Stents; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Obesity; Platelet Aggregation Inhibitors; Retrospective Studies; Thrombosis; Ticlopidine | 2009 |
Platelet reactivity and stent thrombosis: still some issues to solve.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Comorbidity; Coronary Artery Disease; Drug-Eluting Stents; Electrodes; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Assessment; Smoking; Thrombosis; Ticlopidine | 2009 |
Comparison of ticagrelor and thienopyridine P2Y(12) binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasis.
Topics: Adenosine; Animals; CHO Cells; Clopidogrel; Cricetinae; Cricetulus; Disease Models, Animal; Dogs; Hemostasis; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine; Transfection | 2009 |
Upper gastrointestinal bleeding in patients receiving dual antiplatelet therapy after coronary stenting.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Coronary Disease; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
The influence of clinical characteristics, laboratory and inflammatory markers on 'high on-treatment platelet reactivity' as measured with different platelet function tests.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Platelets; Cells, Cultured; Clopidogrel; Drug Combinations; Female; Humans; Interleukin-6; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Sensitivity and Specificity; Thrombosis; Ticlopidine | 2009 |
Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness.
Topics: Aspirin; Blood Platelets; Cells, Cultured; Clopidogrel; Drug Combinations; Feasibility Studies; Humans; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Reproducibility of Results; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Poor performance with a platelet counting technique to monitor clopidogrel inhibitory effects in the point-of-care setting.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Platelet Count; Point-of-Care Systems; Reproducibility of Results; Sensitivity and Specificity; Sweden; Thrombosis; Ticlopidine | 2010 |
A comparison of the VASP index between patients with hemodynamically complicated and uncomplicated acute myocardial infarction.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Biomarkers; Blood Platelets; Case-Control Studies; Catecholamines; Cell Adhesion Molecules; Clopidogrel; Down-Regulation; Drug Monitoring; Female; Hemodynamics; Humans; International Normalized Ratio; Liver Circulation; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Respiration, Artificial; Shock, Cardiogenic; Splanchnic Circulation; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Multiple electrode aggregometry predicts stent thrombosis better than the vasodilator-stimulated phosphoprotein phosphorylation assay.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Electrodes; Female; Humans; Logistic Models; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; ROC Curve; Sensitivity and Specificity; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Antiplatelet effects of clopidogrel and bleeding in patients undergoing coronary stent placement.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Germany; Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Risk Assessment; Risk Factors; ROC Curve; Severity of Illness Index; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Stent thrombosis: a poor man's disease?
Topics: Acute Disease; Aged; Angioplasty, Balloon, Coronary; Chi-Square Distribution; Clopidogrel; Cohort Studies; Coronary Disease; Data Interpretation, Statistical; Diabetes Complications; Drug-Eluting Stents; Female; Follow-Up Studies; Housing; Humans; Male; Metals; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Polytetrafluoroethylene; Residential Facilities; Risk Factors; Smoking; Socioeconomic Factors; Stents; Thrombosis; Ticlopidine; Time Factors | 2009 |
Antiplatelet drugs for patients at high cardiovascular risk. Aspirin generally remains the best choice.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Atrial Fibrillation; Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Risk; Stents; Stroke; Thromboembolism; Thrombosis; Ticlopidine; Warfarin | 2009 |
Imaging of structural changes in endothelial cells and thrombus formation at the site of FeCl(3)-induced injuries in mice cremasteric arteries.
Topics: Animals; Arteries; Aspirin; Blood Platelets; Chlorides; Clopidogrel; Dose-Response Relationship, Drug; Endothelial Cells; Ferric Compounds; Leukocytes; Male; Mice; Mice, Inbred ICR; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2009 |
Antiplatelet effect of 50-mg maintenance dose of clopidogrel compared to 200 mg ticlopidine: a preliminary study.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Asian People; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Humans; Japan; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Platelet activation in essential hypertension: implications for antiplatelet treatment.
Topics: Antihypertensive Agents; Blood Platelet Disorders; Blood Platelets; Clopidogrel; Humans; Hypertension; Platelet Activation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2010 |
VerifyNow and VASP phosphorylation assays give similar results for patients receiving clopidogrel, but they do not always correlate with platelet aggregation.
Topics: Adult; Aged; Aged, 80 and over; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Sensitivity and Specificity; Thrombosis; Ticlopidine | 2010 |
[Perioperative management of patients with coronary stents in non-cardiac surgery].
Topics: Aspirin; Clopidogrel; Coronary Vessels; Drug-Eluting Stents; Elective Surgical Procedures; Guidelines as Topic; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Risk Assessment; Stents; Surgical Procedures, Operative; Thrombosis; Ticlopidine | 2010 |
Triple antiplatelet therapy reduces ischemic events after drug-eluting stent implantation: Drug-Eluting stenting followed by Cilostazol treatment REduces Adverse Serious cardiac Events (DECREASE registry).
Topics: Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Tetrazoles; Thrombosis; Ticlopidine; Time Factors | 2010 |
Antiplatelet therapy after percutaneous coronary intervention: Should another regimen be "TAPT?".
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Chemotherapy, Adjuvant; Cilostazol; Clinical Trials as Topic; Clopidogrel; Contraindications; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Tetrazoles; Thrombosis; Ticlopidine | 2010 |
Antithrombotic effects of Danggui, Honghua and potential drug interaction with clopidogrel.
Topics: Animals; Bleeding Time; Carthamus tinctorius; Clopidogrel; Drug Interactions; Drugs, Chinese Herbal; Male; Pulmonary Embolism; Rats; Rats, Sprague-Dawley; Risk Factors; Thrombosis; Ticlopidine; Venous Thrombosis | 2010 |
Antiplatelet therapy: cangrelor for ACS-lessons from the CHAMPION trials.
Topics: Acute Coronary Syndrome; Adenosine Monophosphate; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
Antithrombotic activity of F 16618, a new PAR1 antagonist evaluated in extracorporeal arterio-venous shunt in the rat.
Topics: Animals; Arterial Occlusive Diseases; Arteriovenous Shunt, Surgical; Aspirin; Bleeding Time; Clopidogrel; Dose-Response Relationship, Drug; Fibrinolytic Agents; Humans; Male; Piperazines; Platelet Aggregation; Pyridines; Rats; Receptor, PAR-1; Thrombosis; Ticlopidine | 2010 |
Clinical relevance of clopidogrel unresponsiveness during elective coronary stenting: experience with the point-of-care platelet function assay-100 C/ADP.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Vessels; Death, Sudden, Cardiac; Drug Resistance; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Preoperative Care; Prospective Studies; Risk Factors; Stents; Thrombosis; Ticlopidine; Time Factors | 2010 |
Optimal duration of clopidogrel use after implantation of drug-eluting stents--still in doubt.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2010 |
Platelet inhibition with cangrelor.
Topics: Adenosine Monophosphate; Administration, Oral; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Infusions, Intravenous; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2010 |
[Multicentric study of thrombosis prevention in upper-extremity microsurgery. Survey at the Fesum centers].
Topics: Aspirin; Clopidogrel; Drug Monitoring; Evidence-Based Practice; Fibrinolytic Agents; France; Hemorrhage; Heparin; Humans; Microsurgery; Perioperative Care; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Pyrrolidines; Research Design; Risk Factors; Skin Transplantation; Surgical Flaps; Thrombosis; Ticlopidine; Upper Extremity | 2010 |
Optimal dual antiplatelet treatment after drug-eluting stent implantation: it's not the time for weaning.
Topics: Clopidogrel; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Prosthesis Implantation; Thrombosis; Ticlopidine | 2010 |
Prasugrel, Māori, and personalised medicine in New Zealand.
Topics: Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Markers; Genetic Testing; Humans; Native Hawaiian or Other Pacific Islander; Pharmacogenetics; Piperazines; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Precision Medicine; Stents; Thiophenes; Thrombosis; Ticlopidine; Vascular Diseases | 2010 |
Late common iliac artery stent thrombosis in a patient with terminal malignancy.
Topics: Aged; Angiography; Aspirin; Atherosclerosis; Carcinoma, Renal Cell; Clopidogrel; Humans; Iliac Artery; Kidney Neoplasms; Male; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2010 |
Synergistic effect of a factor Xa inhibitor, TAK-442, and antiplatelet agents on whole blood coagulation and arterial thrombosis in rats.
Topics: Animals; Aspirin; Blood Coagulation; Blood Coagulation Tests; Clopidogrel; Drug Synergism; Factor Xa Inhibitors; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrimidinones; Rats; Rats, Sprague-Dawley; Sulfones; Thrombosis; Ticlopidine | 2010 |
Clinician-patient discord: exploring differences in perspectives for discontinuing clopidogrel.
Topics: Aged; Attitude of Health Personnel; Attitude to Health; Clopidogrel; Communication; Comorbidity; Drug-Eluting Stents; Female; Humans; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Patients; Physician-Patient Relations; Physicians; Platelet Aggregation Inhibitors; Qualitative Research; Thrombosis; Ticlopidine | 2011 |
Clinical pharmacology: antiplatelet therapy during surgery.
Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombosis; Ticlopidine | 2010 |
Routine platelet testing should not be performed on all patients undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Atherectomy; Blood Platelets; Clopidogrel; Diagnostic Tests, Routine; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Practice Guidelines as Topic; Precision Medicine; Reference Standards; Reference Values; Research Design; Thrombosis; Ticlopidine | 2010 |
Early stent thrombosis with progressive brainstem infarction in a clopidogrel non-responder.
Topics: Aged; Brain Infarction; Brain Ischemia; Clopidogrel; Disease Progression; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2010 |
Role of dual antiplatelet therapy in symptomatic patients with established vascular disease: putting the CHARISMA trial into therapeutic perspective.
Topics: Aspirin; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Retrospective Studies; Risk; Thrombosis; Ticlopidine; Time Factors; Vascular Diseases | 2010 |
[Dental management of patients using anti agregant drugs: background, risks and clinical guidelines].
Topics: Atherosclerosis; Clopidogrel; Dentistry; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Thrombosis; Ticlopidine; Tooth Extraction | 2009 |
Post-thienopyridine platelet response, cardiovascular outcomes, and personalized therapy: En attendant Godot.
Topics: Angioplasty, Balloon, Coronary; Biomarkers; Blood Platelets; Cardiovascular Diseases; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Drug-Eluting Stents; Flow Cytometry; Humans; Microfilament Proteins; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Precision Medicine; Predictive Value of Tests; Prosthesis Design; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Impact of P2Y12 inhibition by clopidogrel on cardiovascular mortality in unselected patients treated by percutaneous coronary angioplasty: a prospective registry.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; Blood Platelets; Cardiovascular Diseases; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Drug-Eluting Stents; Female; Flow Cytometry; France; Humans; Kaplan-Meier Estimate; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Prosthesis Design; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Registries; Risk Assessment; Risk Factors; ROC Curve; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Evaluation of platelet function and pharmacological platelet inhibition in patients with myeloproliferative disorders using multiple electrode aggregometry.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Austria; Case-Control Studies; Clopidogrel; Electrodes; Female; Humans; Linear Models; Male; Middle Aged; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polycythemia Vera; Predictive Value of Tests; Reproducibility of Results; Thrombocythemia, Essential; Thrombosis; Ticlopidine; Treatment Outcome; Young Adult | 2010 |
[Comparison of effects of prasugrel and clopidogrel in patients with acute coronary syndrome, subjected to percutaneous coronary intervention: TRITON-TIMI 38 trial].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Drug-Eluting Stents; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Stroke; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel.
Topics: Animals; Aspirin; Carotid Arteries; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Factor VIIa; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Regional Blood Flow; Thrombosis; Ticlopidine | 2010 |
Risk of drug-eluting stent thrombosis in patients receiving proton pump inhibitors.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Chi-Square Distribution; Clopidogrel; Comorbidity; Confounding Factors, Epidemiologic; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Female; Germany; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Retrospective Studies; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Hand surgery on anticoagulated patients: a prospective study of 121 operations.
Topics: Anticoagulants; Aspirin; Clopidogrel; Hand; Hemostasis, Surgical; Humans; International Normalized Ratio; Perioperative Care; Postoperative Hemorrhage; Thrombosis; Ticlopidine; Tourniquets; Warfarin | 2010 |
Do not adjust the platelet count in light transmittance aggregometry when predicting thrombotic events after percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Humans; Ischemia; Odds Ratio; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; ROC Curve; Thrombosis; Ticlopidine | 2010 |
Does black ethnicity influence the development of stent thrombosis in the drug-eluting stent era?
Topics: Aged; Black People; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Patient Compliance; Platelet Aggregation Inhibitors; Regression Analysis; Retrospective Studies; Risk Factors; Social Class; Thrombosis; Ticlopidine; Treatment Outcome; White People | 2010 |
Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk.
Topics: Animals; Anticoagulants; Clopidogrel; Drug Combinations; Enoxaparin; Factor XI; Hemorrhage; Male; Mice; Mice, Inbred BALB C; Oligonucleotides, Antisense; Thrombosis; Ticlopidine | 2010 |
Frequency and risk of noncardiac surgery after drug-eluting stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Chi-Square Distribution; Clopidogrel; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Risk Assessment; Risk Factors; Surgical Procedures, Operative; Texas; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Triple antiplatelet therapy reduces ischemic events after drug-eluting stent implantation: Drug-Eluting stenting followed by Cilostazol treatment REduces Adverse Serious cardiac Events (DECREASE registry).
Topics: Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Registries; Stents; Tetrazoles; Thrombosis; Ticlopidine; Time Factors | 2010 |
Acute and subacute stent thrombosis after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: incidence, predictors and clinical outcome.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Netherlands; Platelet Aggregation Inhibitors; Registries; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
Prasugrel as alternative treatment strategy in a case with a hypersensitivity reaction to clopidogrel.
Topics: Aged; Angioedema; Clopidogrel; Drug Hypersensitivity; Exanthema; Fever; Humans; Male; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Tachycardia; Thiophenes; Thrombosis; Ticlopidine | 2011 |
Cytochrome P450 2C19 polymorphism, suboptimal reperfusion and all-cause mortality in patients with acute myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Heterozygote; Homozygote; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prevalence; Risk Factors; Stents; Survival Analysis; Thrombosis; Ticlopidine | 2010 |
Acute myocardial infarction and renal infarction in a bodybuilder using anabolic steroids.
Topics: Adult; Anabolic Agents; Angiography; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Enoxaparin; Fibrinolytic Agents; Humans; Infarction; Kidney; Male; Methenolone; Myocardial Infarction; Oxymetholone; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Tomography, X-Ray Computed; Ultrasonography; Weight Lifting | 2010 |
Three-month dual antiplatelet therapy after implantation of zotarolimus-eluting stents: the DATE (Duration of Dual Antiplatelet Therapy AfterImplantation of Endeavor Stent) registry.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Chi-Square Distribution; Clopidogrel; Coronary Angiography; Coronary Stenosis; Disease-Free Survival; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Feasibility Studies; Female; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Prospective Studies; Prosthesis Design; Registries; Republic of Korea; Risk Assessment; Risk Factors; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Impact of concomitant treatment with proton pump inhibitors and clopidogrel on clinical outcome in patients after coronary stent implantation.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Drug Therapy, Combination; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Patient Readmission; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Proton Pump Inhibitors; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Clopidogrel discontinuation and platelet reactivity following coronary stenting.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Epinephrine; Female; Humans; Ireland; Male; Middle Aged; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.
Topics: Animals; Blood Platelets; Clopidogrel; Female; Flow Cytometry; Green Fluorescent Proteins; Guanine Nucleotide Exchange Factors; Hemostasis; Kinetics; Male; Mesentery; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Muscle, Skeletal; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Purinergic P2Y12; Signal Transduction; Thrombosis; Ticlopidine | 2011 |
[Efficacy of stents coated with antibody against CD105 on preventing restenosis and thrombosis in minipigs].
Topics: Animals; Antibodies; Antigens, CD; Aspirin; Clopidogrel; Coronary Restenosis; Endothelial Cells; Neointima; Stents; Swine; Swine, Miniature; Thrombosis; Ticlopidine | 2010 |
Role of intramural platelet thrombus in the pathogenesis of wall rupture and intra-ventricular thrombosis following acute myocardial infarction.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; Disease Models, Animal; Hemodynamics; Inflammation; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Myocardial Infarction; Platelet Aggregation Inhibitors; Telemetry; Thrombosis; Ticlopidine; Time Factors; Ventricular Septal Rupture | 2011 |
A case of resistance to clopidogrel and prasugrel after percutaneous coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Antineoplastic Agents; Clopidogrel; Docetaxel; Drug Resistance; Drug-Eluting Stents; Humans; Male; Middle Aged; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Taxoids; Thiophenes; Thrombosis; Ticlopidine | 2011 |
A case of late epidural hematoma in a patient on clopidogrel therapy postoperatively: when is it safe to resume antiplatelet agents?
Topics: Clopidogrel; Decompression, Surgical; Hematoma, Epidural, Spinal; Humans; Lumbar Vertebrae; Male; Middle Aged; Platelet Aggregation Inhibitors; Spinal Fusion; Spinal Stenosis; Spondylolisthesis; Stents; Thrombosis; Ticlopidine | 2011 |
Impact of cytochrome P450 2C19*2 polymorphism on intra-stent thrombus after drug-eluting stent implantation in Japanese patients receiving clopidogrel.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Asian People; Cardiovascular Agents; Chi-Square Distribution; Cineangiography; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Japan; Logistic Models; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prosthesis Design; Risk Assessment; Risk Factors; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Tomography, Optical Coherence; Treatment Outcome | 2011 |
Thromboresistant surfaces with low-dose anticoagulation alleviate clopidogrel-related complications in patients undergoing coronary artery bypass grafting.
Topics: Aged; Anticoagulants; Biocompatible Materials; Blood Loss, Surgical; Blood Transfusion; Boston; Chest Tubes; Chi-Square Distribution; Clopidogrel; Coronary Artery Bypass; Drainage; Drug Administration Schedule; Equipment Design; Female; Heparin; Humans; Length of Stay; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Beware of being caught on the rebound.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Clopidogrel Resistance: case reports of CYP2C19 gene variants in suspected coronary stent thrombosis.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Stenosis; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Genotype; Humans; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Stents; Thrombosis; Ticlopidine | 2011 |
Catapulting clopidogrel pharmacogenomics forward.
Topics: Amino Acid Substitution; Aryldialkylphosphatase; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Stents; Thrombosis; Ticlopidine | 2011 |
Humanized mouse model of thrombosis is predictive of the clinical efficacy of antiplatelet agents.
Topics: Animals; Biomarkers; Cell Adhesion; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Humans; Mice; Mice, 129 Strain; Mice, Mutant Strains; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Transfusion; Predictive Value of Tests; Receptors, Purinergic P2Y12; Species Specificity; Thrombosis; Ticlopidine; Transplantation, Heterologous; von Willebrand Factor | 2011 |
Functional profile of the platelet P2Y₁₂ receptor signalling pathway in patients with type 2 diabetes mellitus and coronary artery disease.
Topics: Aged; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Thrombosis; Ticlopidine | 2011 |
Overview of the 2010 Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee meeting regarding ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Advisory Committees; Aspirin; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Clopidogrel; Drug Approval; Humans; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Thrombosis; Ticagrelor; Ticlopidine; United States | 2011 |
Clopidogrel differentially affects platelet-mediated thrombosis and inflammatory response in patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Female; Humans; Inflammation; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2011 |
Invited commentary.
Topics: Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Artery Disease; Drainage; Humans; Intubation, Gastrointestinal; Minimally Invasive Surgical Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Premedication; Sternotomy; Thrombosis; Ticlopidine | 2011 |
Conversation with an expert. Plavix: what you need to know.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Costs; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Health Knowledge, Attitudes, Practice; Humans; Patient Education as Topic; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2011 |
An initial experiment with personalized antiplatelet therapy: the GRAVITAS trial.
Topics: Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Precision Medicine; Randomized Controlled Trials as Topic; Risk; Thrombosis; Ticlopidine | 2011 |
Very late thrombosis of flow-diverting constructs after the treatment of large fusiform posterior circulation aneurysms.
Topics: Adult; Cerebral Angiography; Cerebral Revascularization; Cerebrovascular Circulation; Clopidogrel; Fatal Outcome; Female; Humans; Intracranial Aneurysm; Male; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombectomy; Thrombosis; Ticlopidine; Time Factors | 2011 |
A case of subacute thrombosis associated with clopidogrel resistance after implantation of a zotarolimus-eluting stent.
Topics: Aged; Angioplasty, Balloon, Coronary; Anterior Wall Myocardial Infarction; Aryl Hydrocarbon Hydroxylases; Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Resistance; Drug-Eluting Stents; Female; Genotype; Humans; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prosthesis Design; Sirolimus; Thrombectomy; Thrombosis; Ticlopidine; Treatment Outcome; Ultrasonography, Interventional | 2012 |
Discontinuation of long term clopidogrel therapy induces platelet rebound hyperaggregability between 2 and 6 weeks post cessation.
Topics: Aged; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Stents; Thrombosis; Ticlopidine; Time Factors | 2011 |
Left main stent thrombosis complicated by eptifibatide-induced acute thrombocytopenia.
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Aspirin; Cardiac Catheterization; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Therapy, Combination; Electrocardiography; Eptifibatide; Heparin; Humans; Male; Middle Aged; Peptides; Platelet Aggregation Inhibitors; Platelet Count; Stents; Thrombectomy; Thrombocytopenia; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
[Multiple arterial thrombosis and resistance to conventional antiaggregation].
Topics: Aged; Angiography; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Resistance; Electrocardiography; Female; Femoral Artery; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine | 2011 |
High plasma interleukin-6 is associated with drug-eluting stent thrombosis: possible role of inflammatory cytokines in the development of stent thrombosis from the Korea Stent Thrombosis Registry.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; Case-Control Studies; Chemokine CCL2; Chi-Square Distribution; Clopidogrel; Drug-Eluting Stents; Female; Humans; Inflammation Mediators; Interleukin-6; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Prosthesis Design; Registries; Republic of Korea; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Relation between clopidogrel discontinuation and early cardiovascular events after percutaneous coronary intervention with drug-eluting stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; District of Columbia; Drug Administration Schedule; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prosthesis Design; Retrospective Studies; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Wound Healing | 2011 |
Dual antiplatelet therapy and the risk of bleeding.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Warfarin | 2011 |
Impaired inhibition of P2Y(12) by clopidogrel is a major determinant of cardiac death in diabetes mellitus patients treated by percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Resistance; Female; Flow Cytometry; France; Heart Diseases; Humans; Kaplan-Meier Estimate; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proportional Hazards Models; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
The use of contrast echo to clear the left atrial appendage.
Topics: Aspirin; Atrial Appendage; Clopidogrel; Contrast Media; Drug Therapy, Combination; Echocardiography; Echocardiography, Transesophageal; Fluorocarbons; Heart Atria; Heart Diseases; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2011 |
Stent thrombosis after drug eluting stent implantation.
Topics: Angioplasty, Balloon, Coronary; Biomarkers; Chemokine CCL2; Clopidogrel; Drug-Eluting Stents; Humans; Inflammation Mediators; Interleukin-6; Platelet Aggregation Inhibitors; Prosthesis Design; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Optimizing of thienopyridine therapy by multiple electrode platelet aggregometry in clopidogrel low responders undergoing PCI.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Cerebrovascular Disorders; Cilostazol; Clopidogrel; Drug Monitoring; Drug Resistance; Drug Substitution; Electrodes; Female; Germany; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Predictive Value of Tests; Prospective Studies; Risk Assessment; Risk Factors; Stents; Tetrazoles; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
[The CURRENT-OASIS 7 study].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Confidence Intervals; Drug Administration Schedule; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proportional Hazards Models; Randomized Controlled Trials as Topic; Salivary Ducts; Thrombosis; Ticlopidine | 2011 |
High on treatment platelet reactivity and stent thrombosis.
Topics: Adult; Aged; Angioplasty; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2011 |
The impact of noncardiac surgery on selection of a revascularization strategy.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug-Eluting Stents; Humans; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Assessment; Risk Factors; Surgical Procedures, Operative; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Effect of clopidogrel pretreatment on ischemic complications of percutaneous coronary intervention among bivalirudin-treated patients (from the EVENT registry).
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Antithrombins; Clopidogrel; Female; Hemorrhage; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Premedication; Recombinant Proteins; Thrombosis; Ticlopidine | 2011 |
Recurrent ischemic stroke in a patient with ulcerative colitis and high levels of lipoprotein (a).
Topics: Anticholesteremic Agents; Anticoagulants; Aspirin; Atorvastatin; Blood Coagulation Tests; Carotid Stenosis; Clopidogrel; Colitis, Ulcerative; Female; Heparin, Low-Molecular-Weight; Heptanoic Acids; Humans; Lipoprotein(a); Magnetic Resonance Imaging; Middle Aged; Pyrroles; Risk Factors; Stroke; Thrombosis; Ticlopidine; Ultrasonography | 2011 |
Standard- vs high-dose clopidogrel after percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Hemorrhage; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Reproducibility of Results; Risk; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Subacute stent thrombosis owing to complete clopidogrel resistance successfully managed with prasugrel.
Topics: Angioplasty, Balloon, Coronary; Anterior Wall Myocardial Infarction; Clopidogrel; Contraindications; Coronary Artery Disease; Drug Resistance; Drug-Eluting Stents; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis; Ticlopidine; Treatment Failure; Treatment Outcome | 2011 |
A clopidogrel-insensitive inducible pool of P2Y12 receptors contributes to thrombus formation: inhibition by elinogrel, a direct-acting, reversible P2Y12 antagonist.
Topics: Animals; Clopidogrel; Cyclic AMP; Fibrinolytic Agents; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Quinazolinones; Radioligand Assay; Receptors, Purinergic P2Y12; Sulfonamides; Thrombosis; Ticlopidine | 2011 |
Late bare-metal stent thrombosis in a patient with Crohn's disease.
Topics: Adult; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Crohn Disease; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2011 |
PCI and clopidogrel: antiplatelet responsiveness and patient characteristics.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Thrombosis; Ticlopidine | 2011 |
Impact of adjunctive cilostazol therapy versus high maintenance dose of clopidogrel in suboptimal responders with diabetes mellitus.
Topics: Aspirin; Blood Coagulation; Blood Platelets; Cilostazol; Clopidogrel; Diabetes Mellitus, Type 2; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Tetrazoles; Thrombosis; Ticlopidine | 2012 |
Non-cardiac surgery in patients with coronary stents: the RECO study.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Chi-Square Distribution; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Female; France; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Risk Assessment; Risk Factors; Stents; Surgical Procedures, Operative; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Effect of proton pump inhibitors on platelet inhibition activity of clopidogrel in Chinese patients with percutaneous coronary intervention.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Asian; Asian People; Blood Platelets; China; Clopidogrel; Drug Resistance; Esomeprazole; Female; Humans; Lansoprazole; Male; Middle Aged; New York City; Omeprazole; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors | 2011 |
Aspirin plus clopidogrel versus aspirin alone after coronary artery bypass grafting.
Topics: Aspirin; Cerebrovascular Circulation; Clopidogrel; Coronary Artery Bypass; Coronary Vessels; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 2011 |
Abrupt cessation of one-year clopidogrel treatment is not associated with thrombotic events.
Topics: Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Substance Withdrawal Syndrome; Thrombosis; Ticlopidine | 2011 |
Combined influence of proton-pump inhibitors, calcium-channel blockers and CYP2C19*2 on on-treatment platelet reactivity and on the occurrence of atherothrombotic events after percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Laser-Assisted; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Thrombosis; Ticlopidine | 2011 |
Use of prasugrel in a patient with clopidogrel hypersensitivity.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug Hypersensitivity; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
The use of ticagrelor in a patient at increased risk of stent thrombosis resistant to multiple thienopyridines.
Topics: Adenosine; Aged, 80 and over; Cardiac Catheterization; Clopidogrel; Drug-Eluting Stents; Humans; Male; Myocardial Infarction; Purinergic P2Y Receptor Antagonists; Thienopyridines; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2011 |
High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angioplasty; Aspirin; Clopidogrel; Death; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Risk; Stents; Stroke; Thrombosis; Ticlopidine | 2011 |
Applying platelet function testing in clinical practice: what are the unmet needs?
Topics: Acute Coronary Syndrome; Clopidogrel; Cohort Studies; Death; Humans; Myocardial Infarction; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Standard of Care; Stents; Thrombosis; Ticlopidine | 2011 |
[Stent thrombosis and clopidogrel response variability: is the genetic test useful in clinical practice?].
Topics: Acute Coronary Syndrome; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Drug-Eluting Stents; Genetic Testing; Genotype; Humans; Male; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Practice Patterns, Physicians'; Predictive Value of Tests; Risk Assessment; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Effects of P2Y(1) receptor antagonism on the reactivity of platelets from patients with stable coronary artery disease using aspirin and clopidogrel.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y1; Receptors, Thrombin; Thrombosis; Ticlopidine | 2012 |
A case of acute stent thrombosis during treatment with the thrombopoietin receptor agonist peptide--romiplostim.
Topics: Acute Disease; Aspirin; Chest Pain; Clopidogrel; Eptifibatide; Female; Humans; Middle Aged; Peptides; Piperazines; Platelet Aggregation Inhibitors; Platelet Count; Prasugrel Hydrochloride; Purpura, Thrombocytopenic, Idiopathic; Receptors, Thrombopoietin; Risk Factors; Stents; Thiophenes; Thrombosis; Ticlopidine; Ultrasonography, Interventional | 2012 |
Thrombus formation on a left atrial appendage closure device.
Topics: Aged; Anticoagulants; Aspirin; Atrial Appendage; Atrial Fibrillation; Clopidogrel; Equipment Design; Heart Diseases; Heparin; Humans; Male; Postoperative Complications; Septal Occluder Device; Thrombophilia; Thrombosis; Ticlopidine; Ultrasonography | 2011 |
[Diagnostic laparoscopy under dual antiplatelet therapy with clopidogrel and aspirin].
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Diagnosis, Differential; Drug Substitution; Drug Therapy, Combination; Drug-Eluting Stents; Eptifibatide; Female; Humans; Laparoscopy; Multiple Myeloma; Peptides; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Factors; Thrombosis; Ticlopidine | 2011 |
Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control Studies; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Cytochrome P-450 CYP2C19; DNA; Female; France; Genetic Predisposition to Disease; Genotype; Humans; Integrin beta3; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prognosis; Proton Pump Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2011 |
CYP2C19 gene variants cut-off levels for on-clopidogrel platelet aggregation.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Genetic Variation; Humans; Japan; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prevalence; Thrombosis; Ticlopidine | 2012 |
Role of newly formed platelets in thrombus formation in rat after clopidogrel treatment: comparison to the reversible binding P2Y₁₂ antagonist ticagrelor.
Topics: Adenosine; Adenosine Diphosphate; Animals; Blood Platelets; Clopidogrel; Cytoprotection; Platelet Activation; Protein Binding; Purinergic P2Y Receptor Antagonists; Rats; Rats, Inbred WKY; Thrombosis; Ticagrelor; Ticlopidine | 2011 |
Post percutaneous coronary intervention antiplatelet therapy: current perceptions, prospects and perplexity.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Coronary Restenosis; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Hemorrhage; Humans; Metals; Patient Selection; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prosthesis Design; Risk Assessment; Risk Factors; Stents; Tetrazoles; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Clopidogrel use and early outcomes among older patients receiving a drug-eluting coronary artery stent.
Topics: Age Factors; Aged; Aged, 80 and over; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Artery Disease; Coronary Vessels; Dementia; Drug-Eluting Stents; Female; Humans; Male; Medicare Part D; Medication Adherence; Platelet Aggregation Inhibitors; Retrospective Studies; Survival Analysis; Thrombosis; Ticlopidine; United States | 2012 |
Managing antiplatelet therapy during ophthalmic procedures: communication is the key.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Cardiology; Clopidogrel; Humans; Interdisciplinary Communication; Ophthalmologic Surgical Procedures; Ophthalmology; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2011 |
Clopidogrel therapy in ophthalmic procedures: a survey of subspecialty ophthalmologists and review of current guidelines.
Topics: Clopidogrel; Guideline Adherence; Health Knowledge, Attitudes, Practice; Health Surveys; Humans; Medicine; Ophthalmologic Surgical Procedures; Ophthalmology; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Thrombosis; Ticlopidine | 2011 |
Unilateral femoral arterial thrombosis in a dog with malignant mammary gland tumor: clinical and thermographic findings, and successful treatment with local intra-arterial administration of streptokinase.
Topics: Animals; Anticoagulants; Clopidogrel; Dog Diseases; Dogs; Female; Femoral Artery; Fibrinolytic Agents; Mammary Neoplasms, Animal; Streptokinase; Thrombosis; Ticlopidine | 2012 |
Predicting clopidogrel response using DNA samples linked to an electronic health record.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Cytochrome P-450 CYP2C19; Databases, Nucleic Acid; Electronic Health Records; Female; Genotype; Humans; Male; Myocardial Infarction; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Phenotyping vs. genotyping for prediction of clopidogrel efficacy and safety: the PEGASUS-PCI study.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Austria; Blood Platelets; Cardiovascular Diseases; Cell Adhesion Molecules; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Hemorrhage; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Microfilament Proteins; Middle Aged; Multivariate Analysis; Pharmacogenetics; Phenotype; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Predictive Value of Tests; Prospective Studies; Risk Assessment; Risk Factors; Sensitivity and Specificity; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
CYP2C19 and clopidogrel response: more than validation in the real world.
Topics: Clopidogrel; Databases, Nucleic Acid; Electronic Health Records; Female; Humans; Male; Myocardial Infarction; Pharmacogenetics; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2012 |
Bare metal stent thrombosis in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Clopidogrel; Female; Humans; Incidence; Male; Middle Aged; Risk Factors; Smoking; Stents; Thrombosis; Ticlopidine | 2012 |
Successful use of glycoprotein IIb/IIIa inhibitor, heparin, and IABP during PCI in a post-neurosurgical patient with STEMI and cardiogenic shock due to very late bare-metal stent thrombosis.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Heparin; Humans; Intra-Aortic Balloon Pumping; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Complications; Shock, Cardiogenic; Spinal Fusion; Stents; Thrombosis; Ticlopidine | 2012 |
No association of ABCB1 C3435T genotype with clopidogrel response or risk of stent thrombosis in patients undergoing coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Vessels; DNA Mutational Analysis; Drug-Eluting Stents; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Postoperative Complications; Risk; Thrombosis; Ticlopidine | 2012 |
Late peripheral stent thrombosis due to stent fracture, vigorous exercise and hyporesponsiveness to clopidogrel.
Topics: Aged; Angioplasty; Arterial Occlusive Diseases; Bicycling; Clopidogrel; Constriction, Pathologic; Drug Resistance; Exercise; Femoral Artery; Humans; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Prosthesis Design; Prosthesis Failure; Radiography; Risk Factors; Stents; Thrombolytic Therapy; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents?: platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Fibrinolytic Agents; Genetic Testing; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Thrombosis; Ticlopidine | 2012 |
Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents?: the role of platelet reactivity and genotype testing in the prevention of atherothrombotic cardiovascular events remains unproven.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Fibrinolytic Agents; Genetic Testing; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Platelet Function Tests; Prevalence; Prognosis; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Thrombosis; Ticlopidine | 2012 |
Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice.
Topics: Animals; Aspirin; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Hemostasis; Mice; Mice, Knockout; Platelet Activation; Platelet Aggregation Inhibitors; Receptors, Proteinase-Activated; Thrombosis; Ticlopidine | 2012 |
Clopidogrel increases bleeding complications in patients undergoing heart rhythm device procedures.
Topics: Cardiac Resynchronization Therapy; Case-Control Studies; Clopidogrel; Comorbidity; Drug-Related Side Effects and Adverse Reactions; Female; France; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Bridging with glycoprotein IIb/IIIa inhibitors for periprocedural management of antiplatelet therapy in patients with drug eluting stents.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Cardiac Surgical Procedures; Clopidogrel; Drug Administration Schedule; Drug Substitution; Drug-Eluting Stents; Eptifibatide; Female; Humans; Male; Middle Aged; Minnesota; Patient Selection; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Hemorrhage; Retrospective Studies; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
A case of acute coronary artery occlusion associated with very rapid onset heparin-induced thrombosis without thrombocytopenia.
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Aspirin; Autoantibodies; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Occlusion; Drug Therapy, Combination; Female; Heart Failure; Heparin; Humans; Pipecolic Acids; Platelet Count; Platelet Factor 4; Stents; Sulfonamides; Tetrazoles; Thrombosis; Ticlopidine; Time Factors | 2012 |
Protease activated receptor-1 (PAR-1) mediated platelet aggregation is dependent on clopidogrel response.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, PAR-1; Receptors, Thrombin; Thrombosis; Ticlopidine | 2012 |
Comparison of additional versus no additional heparin during therapeutic oral anticoagulation in patients undergoing percutaneous coronary intervention.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Fibrinolytic Agents; Follow-Up Studies; Heparin; Humans; Injections, Subcutaneous; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Prospective Studies; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Warfarin | 2012 |
Computed tomography angiography evaluation of internal carotid artery free-floating thrombus--single-center diagnosis, false-positives, and follow-up.
Topics: Aged; Anticoagulants; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Clopidogrel; Diagnosis, Differential; Female; Fibrinolytic Agents; Heparin; Humans; Male; Thrombosis; Ticlopidine; Tissue Plasminogen Activator; Tomography, X-Ray Computed | 2012 |
Erratum for Fernandez et al. “Comparison of adverse cardiovascular events and bleeding complications of loading dose of clopidogrel 300 mg versus 600 mg in stable patients undergoing elective percutaneous intervention (from the CADICE Study)” Am J Cardiol
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Elective Surgical Procedures; Hemorrhage; Humans; Incidence; Platelet Aggregation Inhibitors; Preoperative Care; Risk Factors; Thrombosis; Ticlopidine; United States | 2012 |
Impaired responsiveness to clopidogrel and aspirin in patients with recurrent stent thrombosis following percutaneous intervention for peripheral artery disease.
Topics: Aged; Angioplasty; Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Peripheral Arterial Disease; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2013 |
Multiple gene polymorphisms predisposing to the prothrombotic state in an adolescent with acute myocardial infarction.
Topics: Adolescent; Anticoagulants; Aspirin; Cholesterol Ester Transfer Proteins; Clopidogrel; Coronary Angiography; Electrocardiography; Fibrinogen; Genetic Predisposition to Disease; Heparin; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thrombosis; Ticlopidine | 2012 |
Comparison of bolus only with bolus plus infusion of bivalirudin in patients undergoing elective percutaneous coronary intervention: a retrospective observational study.
Topics: Aged; Alabama; Antithrombins; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Elective Surgical Procedures; Female; Hemorrhage; Hirudins; Humans; Incidence; Infusions, Intravenous; Injections, Intravenous; Ischemia; Male; Middle Aged; Peptide Fragments; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Recombinant Proteins; Retrospective Studies; Severity of Illness Index; Thrombosis; Ticlopidine | 2012 |
Prasugrel: a guide to its use in patients with acute coronary syndromes undergoing percutaneous coronary intervention in the US.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Economics, Pharmaceutical; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Factors; Thiophenes; Thrombosis; Ticlopidine; United States | 2012 |
Role of the laboratory in monitoring patients receiving dual antiplatelet therapy.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Clinical Laboratory Techniques; Clopidogrel; Drug Resistance; Female; Humans; Logistic Models; Male; Middle Aged; Monitoring, Physiologic; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Reproducibility of Results; Sensitivity and Specificity; Stents; Thrombosis; Ticlopidine | 2012 |
The perioperative management of patients with coronary artery stents: surveying the clinical stakeholders and arriving at a consensus regarding optimal care.
Topics: Adult; Advisory Committees; Alabama; Anesthesiology; Aspirin; Blood Loss, Surgical; Cardiac Catheterization; Cardiology; Clopidogrel; Consensus; Coronary Vessels; Cross-Sectional Studies; Decision Making; Decision Support Techniques; Female; General Surgery; Health Care Surveys; Humans; Male; Middle Aged; Myocardial Ischemia; Perioperative Care; Perioperative Period; Physicians; Platelet Aggregation Inhibitors; Primary Health Care; Risk Factors; Sampling Studies; Stents; Surveys and Questionnaires; Thrombosis; Ticlopidine; Workforce | 2012 |
Evaluation of the role of the new INNOVANCE PFA P2Y test cartridge in detection of clopidogrel resistance.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Blood Platelets; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Longitudinal Studies; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine | 2012 |
Dual thienopyridine low-response to clopidogrel and prasugrel in a patient with STEMI, cardiogenic shock and early stent thrombosis is overcome by ticagrelor.
Topics: Adenosine; Aged; Cardiopulmonary Resuscitation; Clopidogrel; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Shock, Cardiogenic; Stents; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2012 |
Massive epistaxis in a patient with Eisenmenger syndrome: illustrating the clot-versus-bleed conundrum.
Topics: Adult; Aspirin; Clopidogrel; Eisenmenger Complex; Epistaxis; Female; Humans; Platelet Aggregation Inhibitors; Thrombocytopenia; Thrombosis; Ticlopidine | 2011 |
Clopidogrel discontinuation after myocardial infarction and risk of thrombosis: a nationwide cohort study.
Topics: Adult; Aged; Clopidogrel; Denmark; Drug Administration Schedule; Epidemiologic Methods; Female; Graft Occlusion, Vascular; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Failure; Recurrence; Stents; Thrombosis; Ticlopidine; Withholding Treatment | 2012 |
Clopidogrel versus aspirin in patients with atherothrombosis: a CAPRIE-based cost-effectiveness model for Greece.
Topics: Aspirin; Atherosclerosis; Cardiovascular Diseases; Clopidogrel; Cost-Benefit Analysis; Greece; Humans; Models, Economic; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Secondary Prevention; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
[Three case reports of the use of herbal combinations resulted in stent thrombosis: herbal combinations; friend or foe?].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Avena; Chest Pain; Clopidogrel; Coronary Angiography; Coronary Vessels; Female; Humans; Male; Middle Aged; Panax; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Tribulus | 2012 |
Left ventricular assist device thrombosis due to clopidogrel resistance.
Topics: Clopidogrel; Drug Resistance; Heart-Assist Devices; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Failure | 2012 |
Antiplatelet drugs in elective ENT surgery.
Topics: Aspirin; Blood Loss, Surgical; Clinical Protocols; Clopidogrel; Data Collection; Elective Surgical Procedures; Health Knowledge, Attitudes, Practice; Humans; Otolaryngology; Otorhinolaryngologic Surgical Procedures; Perioperative Care; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2012 |
High frequency of CYP2C19*2 carriers in PCI-treated patients switched over from clopidogrel to prasugrel based on platelet function monitoring.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Substitution; Heterozygote; Humans; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine | 2013 |
Failure of high-dose clopidogrel in recurrent stent thrombosis.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug-Eluting Stents; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine; Treatment Failure | 2012 |
Platelets in vascular disease.
Topics: Aspirin; Atherosclerosis; Blood Platelets; Clopidogrel; Hemostasis; Humans; Plaque, Atherosclerotic; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Vascular Diseases | 2013 |
Intracoronary GP IIb/IIIa inhibitors: could eptifibatide be the new kid on the block?
Topics: Clopidogrel; Eptifibatide; Female; Humans; Male; Myocardial Infarction; Myocardial Reperfusion; Peptides; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2012 |
Collagen-induced thrombosis in murine arteries and veins.
Topics: Animals; Arterial Occlusive Diseases; Blood Coagulation; Blood Platelets; Carotid Arteries; Clopidogrel; Collagen; Disease Models, Animal; Epigastric Arteries; Femoral Vein; Fibrin; Mice; Mice, Inbred C57BL; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Time Factors; Venous Thrombosis | 2013 |
Effects of rivaroxaban, acetylsalicylic acid and clopidogrel as monotherapy and in combination in a porcine model of stent thrombosis.
Topics: Animals; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Morpholines; Platelet Aggregation; Rivaroxaban; Stents; Swine; Swine, Miniature; Thiophenes; Thrombosis; Ticlopidine | 2012 |
[Platelet inhibition in clinical practice].
Topics: Aged; Angioplasty, Balloon, Coronary; Arterial Occlusive Diseases; Aspirin; Cerebral Infarction; Clopidogrel; Coronary Artery Bypass; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Patient Compliance; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Transfusion; Risk Factors; Thrombosis; Ticlopidine | 2012 |
Genetic testing in patients with acute coronary syndrome undergoing percutaneous coronary intervention: a cost-effectiveness analysis.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Cerebrovascular Disorders; Clopidogrel; Computer Simulation; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Decision Support Techniques; Disease-Free Survival; Drug Costs; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Health Care Costs; Hemorrhage; Humans; Insurance, Health, Reimbursement; Kaplan-Meier Estimate; Markov Chains; Medicare; Models, Economic; Myocardial Infarction; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Predictive Value of Tests; Quality-Adjusted Life Years; Risk Assessment; Risk Factors; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; United States | 2013 |
Analysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions.
Topics: Adult; Aged; Area Under Curve; Arteries; Aspirin; Automation, Laboratory; Blood Platelets; Capillaries; Case-Control Studies; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Male; Microchip Analytical Procedures; Middle Aged; Monocytes; P-Selectin; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Regional Blood Flow; ROC Curve; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Prevention of stent thrombosis with reduced dose of prasugrel in two patients undergoing treatment of cerebral aneurysms with pipeline embolisation devices.
Topics: Carotid Artery, Internal, Dissection; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
Differential prognostic impact of high on-treatment platelet reactivity among patients with acute coronary syndromes versus stable coronary artery disease undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Coronary Artery Disease; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
The concurrent use of antithrombotic therapies and the risk of bleeding in patients with atrial fibrillation.
Topics: Aged; Atrial Fibrillation; Case-Control Studies; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Middle Aged; Regression Analysis; Risk Factors; Thrombosis; Ticlopidine; United Kingdom; Warfarin | 2013 |
Obesity is associated with poor response to clopidogrel and an increased susceptibility to protease activated receptor-1 mediated platelet activation.
Topics: Adenosine Diphosphate; Aged; Angioplasty; Blood Platelets; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Male; Microfilament Proteins; Middle Aged; Obesity; P-Selectin; Phosphoproteins; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptor, PAR-1; Stents; Thrombosis; Ticlopidine; Translational Research, Biomedical | 2013 |
Clopidogrel-associated vasculopathic cutaneous reaction.
Topics: Aged; Biopsy; Clopidogrel; Fibrin; Fingers; Gangrene; Humans; Male; Platelet Aggregation Inhibitors; Skin; Thrombosis; Ticlopidine | 2013 |
Acute peripheral arterial ischemia and suspected aortic dissection: usefulness of transesophageal echocardiography in differential diagnosis with aortic thrombosis.
Topics: Acute Disease; Adult; Aged; Amputation, Surgical; Anticoagulants; Aortic Diseases; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Diagnosis, Differential; Echocardiography, Transesophageal; Female; Follow-Up Studies; Humans; Ischemia; Leg; Male; Middle Aged; Spain; Thrombectomy; Thrombosis; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome; Warfarin | 2002 |
Effects of combined therapy of clopidogrel and aspirin in preventing thrombus formation on mechanical heart valves in an ex vivo rabbit model.
Topics: Animals; Aspirin; Clopidogrel; Drug Evaluation, Preclinical; Drug Therapy, Combination; Heart Valve Prosthesis; In Vitro Techniques; Male; Microscopy, Electron; Rabbits; Thrombosis; Ticlopidine; Warfarin | 2002 |
Synthesis and thrombolytic activity of new thienopyrimidinone derivatives.
Topics: Animals; Arteries; Clopidogrel; Extracorporeal Circulation; Fibrinolytic Agents; Pyridones; Rats; Rats, Wistar; Thrombosis; Ticlopidine | 2002 |
Thrombophilic causes of retinal vascular thrombosis: etiology and treatment outcomes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Clinical Laboratory Techniques; Clopidogrel; Dalteparin; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retinal Diseases; Retinal Vessels; Thrombophilia; Thrombosis; Ticlopidine; Treatment Outcome | 2002 |
The IST registry.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Beta Particles; Brachytherapy; Clopidogrel; Coronary Restenosis; Drug Therapy, Combination; Gamma Rays; Germany; Humans; Internet; Placebos; Platelet Aggregation Inhibitors; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Registries; Stents; Thrombosis; Ticlopidine; Time Factors | 2002 |
Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement.
Topics: Adenosine Diphosphate; Aged; Angina Pectoris; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prevalence; Prosthesis Implantation; Stents; Thrombosis; Ticlopidine | 2003 |
Antiplatelet drugs.
Topics: Aspirin; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Primary Prevention; Pulmonary Embolism; Thrombosis; Ticlopidine; Venous Thrombosis | 2003 |
Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist.
Topics: Adenosine Diphosphate; Animals; Clopidogrel; Disease Models, Animal; Drug Interactions; Mesenteric Arteries; Mice; Mice, Mutant Strains; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thromboplastin; Thrombosis; Ticlopidine; Vena Cava, Inferior | 2003 |
Regression of intracardiac heparin-induced thrombosis after aortic root surgery.
Topics: Aged; Anticoagulants; Aortic Aneurysm, Thoracic; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Drug Therapy, Combination; Echocardiography, Transesophageal; Follow-Up Studies; Heart Diseases; Heparin, Low-Molecular-Weight; Humans; Risk Assessment; Severity of Illness Index; Thrombocytopenia; Thrombosis; Ticlopidine; Treatment Outcome; Warfarin | 2003 |
Qualitative platelet defect and thrombohaemorrhagic complications in a patient with polycythaemia vera. Case 10.
Topics: Aged; Aspirin; Blood Platelet Disorders; Clopidogrel; Hemorrhage; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polycythemia Vera; Thrombosis; Ticlopidine | 2003 |
Cardiology patient page. Antiplatelet therapy.
Topics: Aspirin; Blood Coagulation; Blood Platelets; Clopidogrel; Heart Diseases; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Ticlopidine | 2003 |
Platelet ADP receptors contribute to the initiation of intravascular coagulation.
Topics: Adult; Animals; Blood Coagulation; Blood Platelets; Clopidogrel; Collagen; Disease Models, Animal; Disseminated Intravascular Coagulation; Factor Xa; Humans; Leukocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Immunoelectron; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Reference Values; Thrombin; Thromboplastin; Thrombosis; Ticlopidine | 2004 |
Complete lysis of left ventricular giant thrombus with fibrinolytic therapy in clopidogrel resistant patient.
Topics: Clopidogrel; Drug Resistance; Electrocardiography; Female; Humans; Middle Aged; Thrombolytic Therapy; Thrombosis; Ticlopidine; Treatment Outcome; Ventricular Dysfunction, Left | 2003 |
[Dual platelet inhibition with clopidogrel and ASS. Who profits from the combination?].
Topics: Acute Disease; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Cyclooxygenase Inhibitors; Drug Synergism; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Stents; Stroke; Syndrome; Thrombosis; Ticlopidine | 2003 |
Red vs white thrombi: treating the right clot is crucial.
Topics: Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 2003 |
Reduced thrombus cohesion in an ex vivo human model of arterial thrombosis induced by clopidogrel treatment: kinetics of the effect and influence of single and double loading-dose regimens.
Topics: Adult; Arterial Occlusive Diseases; Clopidogrel; Confidence Intervals; Drug Administration Schedule; Humans; In Vitro Techniques; Kinetics; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2003 |
Effects of SanOrg123781A, a synthetic hexadecasaccharide, in a mouse model of electrically induced carotid artery injury: synergism with the antiplatelet agent clopidogrel.
Topics: Animals; Carotid Artery Injuries; Carotid Artery Thrombosis; Clopidogrel; Drug Synergism; Electric Injuries; Male; Mice; Mice, Inbred BALB C; Platelet Aggregation; Platelet Aggregation Inhibitors; Polysaccharides; Thrombosis; Ticlopidine | 2004 |
Paclitaxel-eluting coronary stents.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Humans; Paclitaxel; Platelet Aggregation Inhibitors; Pyridines; Stents; Thrombosis; Ticlopidine | 2004 |
807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment.
Topics: Adenosine Diphosphate; Aged; Clopidogrel; Collagen; Coronary Disease; Female; Humans; Integrin alpha2; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stents; Thrombosis; Ticlopidine | 2004 |
Clopidogrel "resistance".
Topics: Clinical Trials as Topic; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Protein Isoforms; Thrombosis; Ticlopidine; Time Factors | 2004 |
Pharmacokinetics of clopidogrel after administration of a high loading dose.
Topics: Administration, Oral; Adult; Area Under Curve; Blood Platelets; Carbon; Chromatography, Liquid; Clopidogrel; Dose-Response Relationship, Drug; Edetic Acid; Female; Humans; Linear Models; Male; Mass Spectrometry; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Sulfhydryl Compounds; Thrombosis; Ticlopidine; Time Factors | 2004 |
Multivessel distal sutureless off-pump coronary artery bypass grafting procedure using magnetic connectors.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Restenosis; Coronary Stenosis; Equipment Design; Humans; Internal Mammary-Coronary Artery Anastomosis; Magnetics; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombosis; Ticlopidine | 2004 |
[Cardiovascular pharmacology].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Fatty Acids, Omega-3; Fibrinolytic Agents; Graft Occlusion, Vascular; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2004 |
Effects of a novel platelet nitric oxide donor (LA816), aspirin, clopidogrel, and combined therapy in inhibiting flow- and lesion-dependent thrombosis in the porcine ex vivo model.
Topics: Adenosine Diphosphate; Amino Acids; Animals; Aspirin; Benzoates; Blood Pressure; Clopidogrel; Collagen; Cyclooxygenase Inhibitors; Drug Evaluation; Drug Therapy, Combination; Fibrinolytic Agents; Free Radical Scavengers; Guanylate Cyclase; Heart Rate; Hemorheology; Imidazoles; Membrane Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Quinoxalines; Random Allocation; Receptors, Purinergic P2Y12; rhoA GTP-Binding Protein; Sus scrofa; Thrombosis; Ticlopidine | 2004 |
Clopidogrel loading dose pre-PCI: how high?
Topics: Clopidogrel; Dose-Response Relationship, Drug; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2004 |
Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting.
Topics: Aged; Clopidogrel; Coronary Vessels; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Predictive Value of Tests; Risk Assessment; Stents; Thrombosis; Ticlopidine | 2005 |
An optimized murine model of ferric chloride-induced arterial thrombosis for thrombosis research.
Topics: Animals; Arterial Occlusive Diseases; Carotid Artery Diseases; Chlorides; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Ferric Compounds; Heparin; Kinetics; Mice; Regional Blood Flow; Research; Thrombosis; Ticlopidine | 2005 |
Long-term combination therapy with aspirin and clopidogrel.
Topics: Angina, Unstable; Arteriosclerosis; Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Humans; Placebos; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Thrombosis; Ticlopidine; Treatment Outcome | 2004 |
Effects of cilostazol on platelet activation in coronary stenting patients who already treated with aspirin and clopidogrel.
Topics: Aspirin; Cilostazol; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Ischemia; P-Selectin; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Tetrazoles; Thrombosis; Ticlopidine | 2004 |
Clopidogrel administration prior to coronary artery bypass grafting surgery: the cardiologist's panacea or the surgeon's headache?
Topics: Aged; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Female; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Hemorrhage; Premedication; Prospective Studies; Reoperation; Risk Factors; Thrombosis; Ticlopidine | 2005 |
Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses.
Topics: Adenosine Diphosphate; Animals; Axl Receptor Tyrosine Kinase; Blood Platelets; c-Mer Tyrosine Kinase; Clopidogrel; Flow Cytometry; Humans; Intercellular Signaling Peptides and Proteins; Mice; Oligopeptides; Oncogene Proteins; Peptides; Platelet Activation; Platelet Aggregation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Saccharomyces cerevisiae Proteins; Signal Transduction; Thrombosis; Ticlopidine | 2005 |
Emerging therapies: clopidogrel and aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prevalence; Research Design; Thrombosis; Ticlopidine; Treatment Outcome | 2005 |
A patient with stent thrombosis, clopidogrel-resistance and failure to metabolize clopidogrel to its active metabolite.
Topics: Aged; Aspirin; Biotransformation; Clopidogrel; Drug Monitoring; Drug Resistance; Humans; Male; Platelet Aggregation; Stents; Thrombosis; Ticlopidine | 2005 |
Stent thrombosis is associated with an impaired response to antiplatelet therapy.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Thrombosis; Ticlopidine | 2005 |
Enhanced shear-induced platelet aggregation in patients who experience subacute stent thrombosis: a case-control study.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Case-Control Studies; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Thrombosis; Ticlopidine | 2005 |
Resistance to antiplatelet resistance is it justified?
Topics: Aspirin; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine | 2005 |
Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk.
Topics: Adenosine Diphosphate; Adult; Aged; Blood Platelets; Calcium Signaling; Case-Control Studies; Clopidogrel; Diabetes Mellitus, Type 2; Humans; In Vitro Techniques; Membrane Proteins; Middle Aged; Phosphatidylserines; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stroke; Thrombin; Thrombosis; Ticlopidine | 2005 |
Pharmacological properties of YM-254890, a specific G(alpha)q/11 inhibitor, on thrombosis and neointima formation in mice.
Topics: Administration, Oral; Animals; Blood Pressure; Carotid Arteries; Cell Proliferation; Chlorides; Chromones; Clopidogrel; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ferric Compounds; GTP-Binding Protein alpha Subunits, Gq-G11; Heart Rate; Male; Mice; Mice, Inbred ICR; Models, Chemical; Morpholines; Muscle, Smooth; Muscle, Smooth, Vascular; Peptides, Cyclic; Platelet Aggregation; Thrombosis; Ticlopidine; Time Factors; Tunica Intima | 2005 |
Clopidogrel use for reducing the rate of thrombosis in a rat model of microarterial anastomosis.
Topics: Anastomosis, Surgical; Animals; Clopidogrel; Double-Blind Method; Femoral Artery; Male; Microsurgery; Models, Animal; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Random Allocation; Rats; Rats, Sprague-Dawley; Thrombosis; Ticlopidine; Treatment Outcome; Vascular Patency | 2005 |
Management and prevention of thrombotic stent occlusion.
Topics: Angioplasty, Balloon, Coronary; Blood Vessel Prosthesis; Clopidogrel; Emergency Treatment; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2005 |
P >0.05 not equal equivalent or noninferior.
Topics: Angioplasty, Balloon, Coronary; Cilostazol; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Research Design; Stents; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2005 |
Serial changes in platelet activation in patients with unstable angina following coronary stenting: evaluation of the effects of clopidogrel loading dose in inhibiting platelet activation.
Topics: Aged; Angina, Unstable; Clopidogrel; Drug Evaluation; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2005 |
Stent thrombosis is associated with an impaired response to antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Humans; Risk Factors; Stents; Thrombosis; Ticlopidine | 2005 |
The cost-effectiveness of dual oral antiplatelet therapy following percutaneous coronary intervention: a Swedish analysis of the CREDO trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Markov Chains; Middle Aged; Models, Econometric; Myocardial Infarction; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Stroke; Sweden; Thrombosis; Ticlopidine | 2005 |
Clopidogrel effect on platelet reactivity in patients with stent thrombosis: results of the CREST Study.
Topics: Aged; Clopidogrel; Coronary Stenosis; Female; Humans; Male; Middle Aged; Platelet Activation; Stents; Thrombosis; Ticlopidine | 2005 |
Triple versus dual antiplatelet therapy after coronary stenting: impact on stent thrombosis.
Topics: Aspirin; Cilostazol; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Tetrazoles; Thrombosis; Ticlopidine | 2005 |
Clopidogrel use in children.
Topics: Adolescent; Cardiac Catheterization; Child; Child, Preschool; Clopidogrel; Drug Administration Schedule; Heart Defects, Congenital; Humans; Infant; Platelet Aggregation Inhibitors; Retrospective Studies; Thrombosis; Ticlopidine | 2005 |
Treatment of wide-necked intracranial aneurysms with a self-expanding stent: mid-term results.
Topics: Aneurysm, Ruptured; Clopidogrel; Follow-Up Studies; Humans; Intracranial Aneurysm; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Subarachnoid Hemorrhage; Thrombosis; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2005 |
Arterial antithrombotic effects of aspirin, heparin, enoxaparin and clopidogrel alone, or in combination, in the rat.
Topics: Animals; Anticoagulants; Aspirin; Bleeding Time; Carotid Arteries; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enoxaparin; Heparin; Male; Models, Animal; Rats; Rats, Sprague-Dawley; Thrombosis; Ticlopidine | 2006 |
[Recommendations for peri-procedural thrombocyte aggregation inhibition].
Topics: Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Heparin; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Surgical Procedures, Operative; Thrombosis; Ticlopidine; Time Factors | 2006 |
Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus- and paclitaxel-eluting stents.
Topics: Aged; Angiography; Case-Control Studies; Clopidogrel; Drug Delivery Systems; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Paclitaxel; Renal Insufficiency; Sirolimus; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2006 |
Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Diabetes Complications; Diabetes Mellitus; Female; Humans; Inflammation; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Substance Withdrawal Syndrome; Thrombosis; Ticlopidine | 2006 |
Recurrent arterial thromboses in a woman with heparin induced thrombocytopenia, successfully managed with iloprost followed by clopidogrel. An alternative therapeutic option for heparin induced thrombocytopenia type II syndrome.
Topics: Aged; Arterial Occlusive Diseases; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Iliac Artery; Iloprost; Leg; Platelet Aggregation Inhibitors; Popliteal Artery; Radiography; Recurrence; Syndrome; Thrombocytopenia; Thrombosis; Ticlopidine; Tinzaparin | 2006 |
Safety of coronary sirolimus-eluting stents in daily clinical practice: one-year follow-up of the e-Cypher registry.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cause of Death; Clopidogrel; Comorbidity; Coronary Disease; Coronary Restenosis; Coronary Stenosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Drug Implants; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Internet; Male; Middle Aged; Myocardial Infarction; Product Surveillance, Postmarketing; Registries; Risk Factors; Sirolimus; Stents; Thrombosis; Ticlopidine; United States | 2006 |
[Postoperative antithrombotic treatment in diabetic patients].
Topics: Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Diabetes Mellitus; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Factors; Thrombosis; Ticlopidine; Warfarin | 2006 |
Basilar artery dolichoectasia with partial thrombosis.
Topics: Aged; Anticholesteremic Agents; Clopidogrel; Humans; Magnetic Resonance Imaging; Male; Platelet Aggregation Inhibitors; Pravastatin; Thrombosis; Ticlopidine; Tomography, X-Ray Computed; Vertebrobasilar Insufficiency | 2006 |
[Thrombosis of a coronary stent after discontinuing treatment with clopidogrel].
Topics: Adult; Aged; Angina Pectoris; Aspirin; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2006 |
Catheter thrombosis during primary percutaneous coronary intervention for acute ST elevation myocardial infarction despite subcutaneous low-molecular-weight heparin, acetylsalicylic acid, clopidogrel and abciximab pretreatment.
Topics: Abciximab; Adult; Aged; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Anticoagulants; Aspirin; Cardiac Catheterization; Clopidogrel; Enoxaparin; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombolytic Therapy; Thrombosis; Ticlopidine | 2006 |
Late in-stent thrombosis following carotid angioplasty and stenting.
Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Angioplasty, Balloon; Anticoagulants; Aphasia; Aspirin; Basal Ganglia; Calcinosis; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Hematuria; Heparin; Humans; Infarction, Middle Cerebral Artery; Male; Mouth Neoplasms; Neck Dissection; Neoplasm Recurrence, Local; Paresis; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Ultrasonography; Urinary Bladder Neoplasms; Vertigo | 2006 |
[Drug-releasing stents. Little use in cardiology despite excellent data--what next?].
Topics: Aspirin; Clopidogrel; Delayed-Action Preparations; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2006 |
[Clopidogrel and aspirin versus aspirin alone in prevention of atherothrombotic events. The results of CHARISMA study].
Topics: Aged; Arteriosclerosis; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Severity of Illness Index; Thrombosis; Ticlopidine; Treatment Outcome | 2006 |
Understanding clopidogrel efficacy in the presence of cytochrome P450 polymorphism.
Topics: Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Embolism, Cholesterol; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Thrombosis; Ticlopidine | 2006 |
A case of fatal stent thrombosis after Carbostent implantation: is clopidogrel alone antiplatelet therapy a safe alternative to aspirin alone antiplatelet therapy?
Topics: Aged; Aspirin; Clopidogrel; Fatal Outcome; Humans; Male; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2007 |
Prevalence, predictors, and outcomes of premature discontinuation of thienopyridine therapy after drug-eluting stent placement: results from the PREMIER registry.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Cardiovascular Agents; Cause of Death; Clopidogrel; Combined Modality Therapy; Coronary Restenosis; Drug Administration Schedule; Drug Implants; Female; Follow-Up Studies; Hospitalization; Humans; Life Tables; Male; Middle Aged; Mortality; Myocardial Infarction; Patient Education as Topic; Platelet Aggregation Inhibitors; Prevalence; Proportional Hazards Models; Prospective Studies; Pyridines; Registries; Sirolimus; Stents; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome; Treatment Refusal | 2006 |
Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Clopidogrel; Coronary Artery Disease; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Signal Transduction; Thrombosis; Thromboxane B2; Ticlopidine; Time Factors; Treatment Refusal | 2006 |
Plavix isn't for everyone. Adding Plavix to aspirin doesn't help people without heart disease.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2006 |
An alternative treatment strategy for pump thrombus in the DeBakey VAD Child: use of clopidogrel as a thrombolytic agent.
Topics: Adolescent; Aspirin; Cardiomyopathy, Dilated; Clopidogrel; Equipment Failure; Fibrinolytic Agents; Heart Transplantation; Heart-Assist Devices; Humans; Male; Thrombosis; Ticlopidine; Warfarin | 2006 |
CHARISMA: the antiplatelet saga continues.
Topics: Atherosclerosis; Clinical Trials as Topic; Clopidogrel; Humans; Ischemia; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Failure | 2006 |
Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin.
Topics: Aged; Angioplasty; Aryl Hydrocarbon Hydroxylases; Aspirin; Cell Adhesion Molecules; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Drug Antagonism; Enzyme Inhibitors; Female; Humans; Male; Microfilament Proteins; Mixed Function Oxygenases; Omeprazole; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Protein Processing, Post-Translational; Thrombosis; Ticlopidine | 2006 |
Cyclooxygenase-2 inhibitors enhance shear stress-induced platelet aggregation.
Topics: Animals; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Stenosis; Cyclooxygenase Inhibitors; Isoxazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Risk Factors; Shear Strength; Thrombosis; Ticlopidine | 2006 |
Iliac anastomotic stenting with a biodegradable poly-L-lactide stent: a preliminary study after 1 and 6 weeks.
Topics: Absorbable Implants; Anastomosis, Surgical; Animals; Arteritis; Aspirin; Clopidogrel; Feasibility Studies; Female; Iliac Artery; Laser-Doppler Flowmetry; Pilot Projects; Platelet Aggregation Inhibitors; Polyesters; Stents; Swine; Thrombosis; Ticlopidine; Tunica Intima; Ultrasonography | 2006 |
Surgical revascularisation in patients with severe limb ischaemia induces a pro-thrombotic state.
Topics: Aged; Aged, 80 and over; Antithrombin III; Arterial Occlusive Diseases; Aspirin; Blood Coagulation; Clopidogrel; Female; Fibrin Fibrinogen Degradation Products; Humans; Ischemia; Male; P-Selectin; Peptide Hydrolases; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Complications; Reperfusion; Thrombosis; Ticlopidine; Vascular Surgical Procedures; von Willebrand Factor | 2006 |
Tackling the diabetic platelet: is high clopidogrel dosing the answer?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Diabetes Mellitus, Type 2; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine | 2006 |
Biosignatures in thrombotic disorders.
Topics: Aspirin; Biomarkers; Clopidogrel; Drug Therapy, Combination; Gene Expression Profiling; Humans; Patient Selection; Platelet Aggregation Inhibitors; Predictive Value of Tests; Risk Factors; Thrombosis; Ticlopidine | 2006 |
Late thrombosis of drug-eluting stents after discontinuation of clopidogrel: report of two cases and review of the literature.
Topics: Aged, 80 and over; Aspirin; Clopidogrel; Coronary Thrombosis; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Radiography; Stents; Thrombosis; Ticlopidine; Time Factors; Ultrasonography | 2006 |
Drug eluting stents.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Restenosis; Drug Implants; Humans; Platelet Aggregation Inhibitors; Prosthesis Failure; Referral and Consultation; Sirolimus; Stents; Thrombosis; Ticlopidine | 2006 |
Platelet reactivity in patients with subacute stent thrombosis compared with non-stent-related acute myocardial infarction.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Female; Flow Cytometry; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2007 |
Does clopidogrel each day keep stent thrombosis away?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Drug Delivery Systems; Humans; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Stents; Thrombosis; Ticlopidine | 2007 |
Late in-stent thrombosis following carotid angioplasty and stenting.
Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Angioplasty, Balloon; Anticoagulants; Aphasia; Aspirin; Basal Ganglia; Calcinosis; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Hematuria; Heparin; Humans; Infarction, Middle Cerebral Artery; Male; Mouth Neoplasms; Neck Dissection; Neoplasm Recurrence, Local; Paresis; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Ultrasonography; Urinary Bladder Neoplasms; Vertigo | 2007 |
Atherothrombotic events and clopidogrel therapy.
Topics: Aged; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Embolism, Cholesterol; Enzyme Inhibitors; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Thrombosis; Ticlopidine | 2007 |
Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits.
Topics: Animals; Aspirin; Blood Coagulation; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Factor Xa; Fibrinolytic Agents; Hemorrhage; Hemostasis; Isoxazoles; Male; Platelet Aggregation; Pyrazoles; Rabbits; Thrombosis; Ticlopidine | 2007 |
Late blood clots tarnish drug-coated stents. Uncommon complication raises questions about who really needs a drug-coated stent and how long to continue drug therapy after getting one.
Topics: Aspirin; Clopidogrel; Coronary Restenosis; Drug Implants; Forecasting; Foreign Bodies; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2007 |
Protein disulphide isomerase-mediated LA419- NO release provides additional antithrombotic effects to the blockade of the ADP receptor.
Topics: Administration, Oral; Animals; Blood Coagulation; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Female; Fibrinolytic Agents; Isosorbide Dinitrate; Nitric Oxide; Nitric Oxide Donors; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Disulfide-Isomerases; Proteomics; Purinergic P2 Receptor Antagonists; Random Allocation; Receptors, Purinergic P2; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Thrombosis; Ticlopidine; Vasodilator Agents | 2007 |
Ticlopidine could be an alternative therapy in the case of pharmacological resistance to clopidogrel: a report of three cases.
Topics: Aged; Angina, Unstable; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2007 |
Clopidogrel (Plavix) reduces the rate of thrombosis in the rat tuck model for microvenous anastomosis.
Topics: Anastomosis, Surgical; Animals; Clopidogrel; Male; Microsurgery; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Suture Techniques; Thrombosis; Ticlopidine; Vascular Surgical Procedures; Veins | 2007 |
[Acute stent thrombosis due to resistance to clopidogrel ? A case report].
Topics: Aged; Clopidogrel; Drug Resistance; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2007 |
A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models.
Topics: Animals; Arteriovenous Shunt, Surgical; Carotid Artery Injuries; Clopidogrel; Disease Models, Animal; Dogs; In Vitro Techniques; Male; Membrane Proteins; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine | 2007 |
Impact of platelet reactivity after clopidogrel administration on drug-eluting stent thrombosis.
Topics: Adult; Antineoplastic Agents, Phytogenic; Blood Platelets; Clopidogrel; Comorbidity; Female; Humans; Immunosuppressive Agents; Male; Multivariate Analysis; Myocardial Ischemia; Paclitaxel; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Sirolimus; Stents; Thrombosis; Ticlopidine | 2007 |
Unraveling questions surrounding clopidogrel resistance and stent thrombosis: one less snag.
Topics: Blood Platelets; Clopidogrel; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2007 |
[Modified platelet aggregation test in patients on ASA and/or clopidogrel].
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epinephrine; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Thrombosis; Ticlopidine | 2007 |
Drug-eluting stents: dual antiplatelet therapy for every survivor?
Topics: Algorithms; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Incidence; Paclitaxel; Platelet Aggregation Inhibitors; Pyridines; Sirolimus; Stents; Survivors; Thrombosis; Ticlopidine | 2007 |
The lack of endothelization after drug-eluting stent implantation as a cause of fatal late stent thrombosis.
Topics: Angioplasty, Balloon, Coronary; Autopsy; Cardiovascular Agents; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Endothelial Cells; Fatal Outcome; Humans; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Prosthesis Design; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
A thromboxane A2/prostaglandin H2 receptor antagonist (S18886) shows high antithrombotic efficacy in an experimental model of stent-induced thrombosis.
Topics: Administration, Oral; Animals; Aorta; Aspirin; Bleeding Time; Blood Coagulation; Clopidogrel; Disease Models, Animal; Fibrin; Fibrinogen; Fibrinolytic Agents; Hemorrhage; Naphthalenes; Platelet Activation; Platelet Aggregation Inhibitors; Propionates; Prosthesis Design; Receptors, Thromboxane A2, Prostaglandin H2; Stainless Steel; Stents; Swine; Thrombosis; Ticlopidine; Time Factors | 2007 |
Impaired platelet responsiveness to clopidogrel identified by flow cytometric vasodilator-stimulated phosphoprotein (VASP) phosphorylation in patients with subacute stent thrombosis.
Topics: Aged; Algorithms; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Models, Biological; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2007 |
Late coronary stent thrombosis complicating urologic surgery.
Topics: Aged; Clopidogrel; Coronary Stenosis; Drug-Eluting Stents; Fatal Outcome; Humans; Immunosuppressive Agents; Lymph Node Excision; Male; Paclitaxel; Platelet Aggregation Inhibitors; Prostatic Neoplasms; Thrombosis; Ticlopidine; Withholding Treatment | 2008 |
Post-stenting antithrombotic drug therapy in patients with atrial fibrillation.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Fibrinolytic Agents; Humans; Practice Guidelines as Topic; Risk Factors; Stents; Thrombosis; Ticlopidine; Warfarin | 2007 |
Repeat oral dosing of prasugrel, a novel P2Y12 receptor inhibitor, results in cumulative and potent antiplatelet and antithrombotic activity in several animal species.
Topics: Administration, Oral; Adult; Animals; Clopidogrel; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; In Vitro Techniques; Macaca fascicularis; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Thiophenes; Thrombosis; Ticlopidine | 2008 |
Aspirin + clopidogrel therapy: how does your care compare to the evidence?
Topics: Acute Coronary Syndrome; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Evidence-Based Medicine; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Secondary Prevention; Stroke; Thrombosis; Ticlopidine | 2008 |
Coronary artery stenting in patients treated by clopidogrel without aspirin.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2009 |
Effect of chronic treatment with acetylsalicylic acid and clopidogrel on atheroprogression and atherothrombosis in ApoE-deficient mice in vivo.
Topics: Animals; Aorta; Apolipoproteins E; Aspirin; Atherosclerosis; Blood Platelets; Carotid Arteries; Cholesterol, Dietary; Clopidogrel; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Endothelial Cells; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Microscopy, Video; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Rupture; Thrombosis; Ticlopidine; Time Factors | 2008 |
Prevention of thrombosis in polycythemia vera and essential thrombocythemia.
Topics: Arterial Occlusive Diseases; Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Hydroxyurea; Janus Kinase 2; Multicenter Studies as Topic; Phlebotomy; Polycythemia Vera; Retrospective Studies; Risk Factors; Severity of Illness Index; Thrombocythemia, Essential; Thrombophilia; Thrombosis; Ticlopidine; Venous Thrombosis | 2008 |
Effect of clopidogrel pretreatment on angiographic and clinical outcomes in patients undergoing primary percutaneous coronary intervention for ST-elevation acute myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Female; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation Inhibitors; Premedication; Prospective Studies; Recurrence; Registries; Retreatment; Stents; Thrombosis; Ticlopidine | 2008 |
Effects of diabetes mellitus on platelet reactivity after dual antiplatelet therapy with aspirin and clopidogrel.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cohort Studies; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Comparison of PD0348292, a selective factor Xa inhibitor, to antiplatelet agents for the inhibition of arterial thrombosis.
Topics: Administration, Oral; Animals; Aspirin; Bleeding Time; Blood Coagulation; Carotid Artery Injuries; Carotid Artery Thrombosis; Clopidogrel; Disease Models, Animal; Factor Xa Inhibitors; Female; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridones; Pyrrolidines; Sus scrofa; Thrombosis; Ticlopidine | 2008 |
Platelet activation and atherothrombosis.
Topics: Acute Coronary Syndrome; Aspirin; Atherosclerosis; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Vascular Diseases | 2008 |
What anti-thrombotic therapy is best with primary PCI for acute ST elevation myocardial infarction: how should the HORIZONS trial change current practice?
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Cardiovascular Diseases; Clopidogrel; Fibrinolytic Agents; Hemorrhage; Heparin; Hirudins; Humans; Myocardial Infarction; Patient Selection; Peptide Fragments; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Recombinant Proteins; Research Design; Stents; Thrombin; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Observance of antiplatelet therapy after stent implantation in patients under chronic oral anticoagulant treatment.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Drug Delivery Systems; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Patient Compliance; Platelet Aggregation Inhibitors; Stents; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
For better or for worse: the future of antiplatelet therapy.
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Disease; Forecasting; Hemorrhage; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stroke; Thiophenes; Thrombolytic Therapy; Thrombosis; Ticlopidine | 2008 |
Aprotinin reduces clopidogrel-induced prolongation of the bleeding time in the rat.
Topics: Animals; Aprotinin; Arteriovenous Shunt, Surgical; Bleeding Time; Clopidogrel; Constriction; Hemorrhagic Disorders; Hemostasis; Rats; Rats, Sprague-Dawley; Thromboplastin; Thrombosis; Ticlopidine | 1993 |
An experimental myocardial infarction model in the rat and its properties.
Topics: Animals; Biphenyl Compounds; Clopidogrel; Coronary Vessels; Disease Models, Animal; Electrocardiography; Heptanoic Acids; Ketanserin; Male; Myocardial Infarction; Oxygen; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombosis; Ticlopidine | 1995 |
Effect of aspirin and clopidogrel on platelet-dependent tissue factor expression in endothelial cells.
Topics: Adenosine Diphosphate; Animals; Aorta; Aspirin; Blood Platelets; Cattle; Clopidogrel; Endothelium, Vascular; Female; Ligation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Thionucleotides; Thrombin; Thromboplastin; Thrombosis; Ticlopidine; Vena Cava, Inferior | 1994 |
Potentiating effect of clopidogrel and SR 46349, a novel 5-HT2 antagonist, on streptokinase-induced thrombolysis in the rabbit.
Topics: Animals; Bleeding Time; Clopidogrel; Drug Synergism; Fibrinolytic Agents; Fluorobenzenes; Jugular Veins; Male; Phenols; Platelet Aggregation Inhibitors; Rabbits; Serotonin Antagonists; Streptokinase; Thrombolytic Therapy; Thrombosis; Ticlopidine | 1993 |
Clopidogrel: a new safe and effective antiplatelet agent. But unanswered questions remain.
Topics: Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 1997 |
Antiplatelet and antithrombotic efficacy of SR 121787, a nonpeptide orally active GP IIb/IIIa antagonist, in rabbits: comparison with clopidogrel and aspirin.
Topics: Animals; Aspirin; Benzylamines; Clopidogrel; Hemodynamics; Hemostasis; Male; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Thiazoles; Thrombosis; Ticlopidine | 1997 |
[Thrombosis prophylaxis after stroke].
Topics: Anticoagulants; Aspirin; Cerebrovascular Disorders; Clopidogrel; Heparin; Humans; Middle Aged; Platelet Aggregation Inhibitors; Primary Prevention; Risk Factors; Thromboembolism; Thrombosis; Ticlopidine | 1998 |
[Secondary cardiovascular prevention: convincing evidence concerning clopidogrel].
Topics: Arteriosclerosis; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 1998 |
The antiaggregating and antithrombotic activity of clopidogrel is potentiated by aspirin in several experimental models in the rabbit.
Topics: Animals; Aspirin; Clopidogrel; Constriction, Pathologic; Drug Synergism; Femoral Artery; Fibrinolytic Agents; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thrombosis; Ticlopidine | 1998 |
Clopidogrel inhibition of stent, graft, and vascular thrombogenesis with antithrombotic enhancement by aspirin in nonhuman primates.
Topics: Animals; Aspirin; Bleeding Time; Clopidogrel; Drug Interactions; Endarterectomy; Hemostasis; Heparin; Male; Papio; Platelet Aggregation Inhibitors; Polyethylene Terephthalates; Stents; Thrombosis; Ticlopidine | 1998 |
Rationale for antiplatelet therapy in patients with atherothrombotic disease.
Topics: Arteriosclerosis; Clopidogrel; Controlled Clinical Trials as Topic; Cyclooxygenase Inhibitors; Epoprostenol; Female; Fibrinolytic Agents; Humans; Male; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2 Receptor Antagonists; Thrombosis; Ticlopidine | 1998 |
Effect of clopidogrel on thrombin generation in platelet-rich plasma in the rat.
Topics: Animals; Blood Platelets; Clopidogrel; Flow Cytometry; Male; Platelet Activation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombin; Thrombosis; Ticlopidine | 1999 |
Comparison of the antithrombotic effects of heparin, hirudin and clopidogrel according to the nature of the thrombogenic surface in an arterioarterial shunt in rats.
Topics: Animals; Clopidogrel; Disease Models, Animal; Female; Fibrinolytic Agents; Heparin; Hirudins; Rats; Rats, Wistar; Thrombosis; Ticlopidine | 1999 |
The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arteriovenous Shunt, Surgical; Binding, Competitive; Bleeding Time; Blood Platelets; Clopidogrel; Collagen; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Thiophenes; Thrombin; Thrombosis; Ticlopidine; Time Factors; Tritium | 2000 |
[Contribution of platelet aggregation inhibitors in the prevention of complications of atherothrombosis].
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Risk Factors; Thrombosis; Ticlopidine; Vascular Diseases | 2000 |
Combination therapy with clopidogrel and aspirin after coronary stenting.
Topics: Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2000 |
Consider this: It's too little!
Topics: Clopidogrel; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2000 |
Clopidogrel instead of ticlopidine after coronary stent placement: is the switch justified?
Topics: Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Thrombosis; Ticlopidine | 2000 |
A pharmacodynamic study of clopidogrel in chronic hemodialysis patients.
Topics: Adenosine Diphosphate; Arterial Occlusive Diseases; Chronic Disease; Clopidogrel; Dose-Response Relationship, Drug; Hemostasis; Humans; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Renal Dialysis; Renal Insufficiency; Thrombosis; Ticlopidine | 2000 |
Combination therapy with aspirin plus clopidogrel versus aspirin plus ticlopidine for prevention of subacute thrombosis after successful native coronary stenting.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Thrombosis; Ticlopidine; Treatment Outcome; Ultrasonography, Interventional | 2001 |
Radiation-induced glomerular thrombus formation and nephropathy are not prevented by the ADP receptor antagonist clopidogrel.
Topics: Animals; Apyrase; Clopidogrel; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Edetic Acid; Female; Fibrin Fibrinogen Degradation Products; Fibrinolytic Agents; Glomerular Filtration Rate; Image Processing, Computer-Assisted; Kidney Function Tests; Kidney Glomerulus; Mice; Mice, Inbred C3H; Mice, Nude; Purinergic P2 Receptor Antagonists; Radiation Injuries, Experimental; Radiation Tolerance; Thrombosis; Ticlopidine | 2001 |
Effect of 300- and 450-mg clopidogrel loading doses on membrane and soluble P-selectin in patients undergoing coronary stent implantation.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Apyrase; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Thrombosis; Ticlopidine | 2002 |
Oral anticoagulation for acute coronary syndromes.
Topics: Administration, Oral; Aged; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Clopidogrel; Controlled Clinical Trials as Topic; Diabetes Complications; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Echocardiography; Electrocardiography; Female; Humans; International Normalized Ratio; Male; Middle Aged; Myocardial Infarction; Patient Care Planning; Risk Factors; Stroke; Thrombosis; Ticlopidine; Warfarin | 2002 |
Comparative arterial antithrombotic activity of clopidogrel and acetyl salicylic acid in the pig.
Topics: Animals; Aspirin; Bleeding Time; Clopidogrel; Disease Models, Animal; Female; Femoral Artery; Fibrinolytic Agents; Male; Platelet Aggregation; Swine; Thrombosis; Ticlopidine | 1992 |
[Antiplatelet effect of clopidogrel].
Topics: Adenosine Diphosphate; Adolescent; Adult; Animals; Bleeding Time; Clopidogrel; Disease Models, Animal; Dogs; Drug Evaluation; Female; Humans; Intracranial Embolism and Thrombosis; Male; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Rabbits; Rats; Thrombosis; Ticlopidine | 1992 |
[Arterioarterial shunt coated with collagen. A model of acute arterial thrombosis for testing antithrombotic agents in rats].
Topics: Animals; Aspirin; Carotid Arteries; Clopidogrel; Collagen; Disease Models, Animal; Fistula; Graft Occlusion, Vascular; Male; Models, Biological; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thrombolytic Therapy; Thrombosis; Ticlopidine | 1991 |
ADP plays a key role in thrombogenesis in rats.
Topics: Adenosine Diphosphate; Animals; Clopidogrel; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; In Vitro Techniques; Ketanserin; Platelet Aggregation; Rats; Rats, Inbred Strains; Serotonin; Thrombosis; Ticlopidine | 1988 |