Compounds > clopidogrel

clopidogrel and Genetic Predisposition

clopidogrel has been researched along with Genetic Predisposition in 50 studies

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (10.00)29.6817
2010's39 (78.00)24.3611
2020's6 (12.00)2.80

Authors

AuthorsStudies
Bath, PM; Jiang, Y; Jing, J; Johnston, SC; Li, H; Li, Y; Li, Z; Lin, J; Liu, J; Liu, L; Meng, X; Tian, X; Wang, A; Wang, F; Wang, Y; Xie, X; Zhao, X; Zuo, Y1
Cai, JT; He, YY; Lin, YL; Liu, HY; Rao, QM; Zhang, T1
Bhatta, RS; Chhonker, YS; Dikshit, M; Kanuri, BN; Misra, A; Narain, VS; Negi, MPS; Pandey, CP1
Chen, S; Liu, G; Yang, S1
Blanco, P; Bonnet, F; Duffau, P; Gensous, N; Lazaro, E; Pellegrin, I; Richez, C; Savel, H; Thiebaut, R; Truchetet, ME; Vial, G1
Andersen, MS; Bandres-Ciga, S; Gan-Or, Z; Hardy, J; Holtman, IR; Krohn, L; Pihlstrøm, L; Reynolds, RH; Ryten, M1
Court, MH; Kovacs, SL; Li, RHL; Nguyen, N; Oldach, MS; Ontiveros, ES; Stern, JA; Ueda, Y; Vernau, KM1
Chen, X; Cui, H; Du, W; Ji, L; Li, X; Liu, T; Su, J; Tong, M; Xia, Y; Xu, H; Yang, J; Yao, Q; Yu, J; Yu, Q; Zhang, J; Zheng, Y; Zhu, H; Zhu, Y1
He, X; Hou, J; Li, B; Li, C; Liu, Z; Wu, H; Yang, M; Zhang, Q; Zhao, P; Zhong, M; Zhong, W; Zhong, Z1
Antonijevic, N; Kusic-Tisma, J; Matic, D; Novkovic, M; Radojkovic, D; Rakicevic, L1
Åkerblom, A; Becker, RC; Eriksson, N; Himmelmann, A; James, SK; Parker, WAE; Storey, RF; Voora, D; Wallentin, L1
Baccar, H; Boughalleb, M; Charfi, R; Gorgi, Y; Hammami, N; Hosni, H; Kharrat, M; Klouz, A; Kouidhi, S; Limam, M; Mrabet, A; Mzoughi, K; Sfar, I; Trabelsi, S; Zaïri, I; Zedini, C1
Castelli, P; Cosentino, M; Ferrari, M; Marino, F; Mirabile, M; Riva, F; Tarallo, A; Tozzi, M1
Åkerblom, A; Asselbergs, FW; Becker, RC; Bernlochner, I; Bopp, R; Byrne, RA; Erdmann, J; Eriksson, N; James, S; Kastrati, A; Katus, HA; Kessler, T; Koenig, W; Kofink, D; Laugwitz, KL; Mahmoodi, BK; Mayer, K; Munz, M; Nordio, F; O'Donoghue, ML; Rai, H; Sager, HB; Schunkert, H; Sibbing, D; Solakov, L; Storey, RF; Ten Berg, JM; Tragante, V; Wallentin, L; Wobst, J; Wolf, B1
Chen, JY; Kang, YH; Lai, WH; Lao, HY; Li, XX; Wu, H; Yu, XY; Zhong, SL1
Akgün, T; Can, MM; Kaymaz, C; Koca, F; Kurt, M; Ozkan, A; Tanboğa, IH; Tokgöz, HC1
Bakirci, EM; Borekci, A; Kalkan, K; Karakoyun, S; Sevimli, S; Topcu, S; Vançelik, S1
Valgimigli, M1
Chen, X; Cui, H; Du, W; Fei, X; Li, X; Lin, S; Liu, J; Liu, Y; Song, H; Su, J; Tong, M; Wang, J; Wang, Y; Xu, J; Yu, Q; Zhang, L; Zheng, W; Zhong, J1
Ensminger, SM; Gebhardt, J; Heim, C; Jacobi, J; Ramsperger-Gleixner, M; Weyand, M1
Cao, H; Wang, DG; Wei, YQ; Yang, H1
Chan, J; Churilov, L; Dowling, RJ; Kwan, P; Lin, M; Mitchell, PJ; Ramdave, S; Todaro, M; Yan, B; Zhu, WS1
Fang, L; Huang, H; Lin, M; Wang, N; Yang, Z; Zhao, Y1
Kilpatrick, LE; Kunapuli, SP; Liverani, E; Rico, MC; Tsygankov, AY1
Chen, Y; Gao, CY; Yang, HH1
Harris, SP; Ho, V; Li, RH; Stern, JA; Tablin, F1
El Amri, H; Zaiou, M1
Bian, S; Dong, P; Yang, X1
Hayden, EC1
Heo, JH; Kim, M1
Haraguchi, Y; Hariki, H; Hirata, K; Honjo, T; Inoue, T; Ishida, T; Kawamori, H; Kozuki, A; Nishio, R; Sawada, T; Shinke, T; Shinohara, M; Shite, J; Toh, R1
Becker, RC; Harrington, RA; James, SK; Wallentin, L1
Lischke, S; Schneider, DJ1
Donnikov, AE; Dzhalilova, GV; Iliushchenko, TA; Komarov, AL; Panchenko, EP; Shakhmatova, OO1
Jeong, YH; Kim, IS; Park, Y1
Alexopoulos, D; Athanassiadou, A; Davlouros, P; Kassimis, G; Stavrou, EF; Xanthopoulou, I1
Allanic, F; Barthélémy, O; Beygui, F; Cayla, G; Collet, JP; de la Briolle, A; Gruel, Y; Huerre, Y; Hulot, JS; Montalescot, G; O'Connor, SA; Pathak, A; Scott, SA; Silvain, J; Vignalou, JB1
Wiwanitkit, V1
Hu, B; Luo, Y; Qi, WG; Verdo, A; Zhang, DF; Zhao, YT1
Hu, YF; Li, Y; Tang, HL; Xie, HG1
Polasek, TM; Sorich, MJ; Wiese, MD1
Doğan, A; Erdogan, D; Icli, A; Varol, E1
Ashley, EA; Salari, K; Watkins, H1
de la Peña, NC; Isordia-Salas, I; Olalde-Román, MJ; Santiago-Germán, D; Valencia-Sánchez, JS1
Berger, JS; Hochman, JS; Ladapo, JA; Lala, A; Scott Braithwaite, R; Sharma, G1
Anderson, JL; Carlquist, JF; Horne, BD; Huntinghouse, JA; Knight, S; May, H; Muhlestein, JB; Rollo, JS1
SoRelle, R1
Amighi, J; Brunner, M; Exner, M; Felber, K; Funk, M; Mannhalter, C; Minar, E; Mlekusch, W; Müller, M; Sabeti, S; Schillinger, M; Ziegler, S1
Hetzer, R; Potapov, EV1
Angiolillo, D; Bates, E; Berger, PB; Bhatt, D; Braunwald, E; Cannon, CP; Furman, MI; Gurbel, P; Michelson, AD; Peterson, E; Wiviott, S1

Reviews

7 review(s) available for clopidogrel and Genetic Predisposition

ArticleYear
Identifying responsiveness to oral P2Y12 receptor blockers: platelet function assays and genetic tests.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2013, Volume: 14 Suppl 1

    Topics: Acute Coronary Syndrome; Administration, Oral; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Drug Monitoring; Genetic Predisposition to Disease; Genetic Testing; Humans; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome

2013
Cardiovascular pharmacogenetics: a promise for genomically-guided therapy and personalized medicine.
    Clinical genetics, 2017, Volume: 91, Issue:3

    Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Genetic Predisposition to Disease; Genetic Variation; Genome, Human; Genomics; Humans; Pharmacogenetics; Precision Medicine; Ticlopidine; Warfarin

2017
Recent developments in the use of antiplatelet agents to prevent cardiovascular events.
    Future cardiology, 2011, Volume: 7, Issue:3

    Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Fibrinolytic Agents; Genetic Predisposition to Disease; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine

2011
The gain-of-function variant allele CYP2C19*17: a double-edged sword between thrombosis and bleeding in clopidogrel-treated patients.
    Journal of thrombosis and haemostasis : JTH, 2012, Volume: 10, Issue:2

    Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Predisposition to Disease; Genetic Variation; Hemorrhage; Humans; Odds Ratio; Phenotype; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome

2012
Systematic review and meta-analysis of the association between cytochrome P450 2C19 genotype and bleeding.
    Thrombosis and haemostasis, 2012, Volume: 108, Issue:1

    Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Hemorrhage; Humans; Polymorphism, Genetic; Risk; Thrombosis; Ticlopidine

2012
Personalized medicine: hope or hype?
    European heart journal, 2012, Volume: 33, Issue:13

    Topics: Anticoagulants; Cardiovascular Diseases; Clopidogrel; Genetic Predisposition to Disease; Genetic Testing; Genetic Variation; Genome, Human; Humans; Mutation; Neoplasms; Pharmacogenetics; Platelet Aggregation Inhibitors; Precision Medicine; Risk Adjustment; Ticlopidine; Warfarin

2012
Investigating the mechanisms of hyporesponse to antiplatelet approaches.
    Clinical cardiology, 2008, Volume: 31, Issue:3 Suppl 1

    Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Genetic Predisposition to Disease; Humans; Patient Selection; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome

2008

Trials

5 trial(s) available for clopidogrel and Genetic Predisposition

ArticleYear
Bleeding Risk of Dual Antiplatelet Therapy after Minor Stroke or Transient Ischemic Attack.
    Annals of neurology, 2022, Volume: 91, Issue:3

    Topics: Aged; Alleles; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Genetic Predisposition to Disease; Hemorrhage; Humans; Ischemic Attack, Transient; Ischemic Stroke; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Treatment Outcome

2022
The impact of clopidogrel on plasma-soluble CD40 ligand levels in systemic lupus erythematosus patients: the CLOPUS phase I/II pilot study.
    Joint bone spine, 2021, Volume: 88, Issue:2

    Topics: CD40 Ligand; Clopidogrel; Genetic Predisposition to Disease; Humans; Lupus Erythematosus, Systemic; Pilot Projects

2021
Genetic Polymorphism of CYP2C19 and Inhibitory Effects of Ticagrelor and Clopidogrel Towards Post-Percutaneous Coronary Intervention (PCI) Platelet Aggregation in Patients with Acute Coronary Syndromes.
    Medical science monitor : international medical journal of experimental and clinical research, 2016, Dec-15, Volume: 22

    Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticagrelor; Ticlopidine; Treatment Outcome

2016
CYP2C19*2 and other genetic variants affecting platelet response to clopidogrel in patients undergoing percutaneous coronary intervention.
    Thrombosis research, 2012, Volume: 129, Issue:4

    Topics: Clopidogrel; Comorbidity; Coronary Artery Disease; Cytokines; Female; Genetic Predisposition to Disease; Greece; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Prevalence; Stents; Thrombosis; Ticlopidine; Treatment Outcome

2012
The impact of CYP3A5*1/*3, PIA1/A2 and T744C polymorphisms on clopidogrel and acetylsalicylic acid response variability in Mexican population.
    Thrombosis research, 2012, Volume: 130, Issue:3

    Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Comorbidity; Cytochrome P-450 CYP3A; Drug Resistance; Female; Genetic Predisposition to Disease; Genetic Variation; Humans; Male; Mexico; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Single Nucleotide; Prevalence; Receptors, Purinergic P2Y12; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome

2012

Other Studies

38 other study(ies) available for clopidogrel and Genetic Predisposition

ArticleYear
[Association of
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2022, Mar-06, Volume: 56, Issue:3

    Topics: Adolescent; Adult; Alleles; Arylamine N-Acetyltransferase; ATP Binding Cassette Transporter, Subfamily B; Case-Control Studies; Clopidogrel; Cytochrome P-450 CYP2C19; Depressive Disorder, Major; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; NAV1.2 Voltage-Gated Sodium Channel; Polymorphism, Single Nucleotide; Young Adult

2022
Aspirin & clopidogrel non-responsiveness & its association with genetic polymorphisms in patients with myocardial infarction.
    The Indian journal of medical research, 2019, Volume: 150, Issue:1

    Topics: Aged; Alleles; Aspirin; CD40 Ligand; Clopidogrel; Cyclooxygenase 1; Cytochrome P-450 Enzyme System; Dual Anti-Platelet Therapy; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Polymorphism, Genetic; Receptors, Purinergic P2Y12; Thromboxane B2

2019
The correlation between recurrent risk and CYP2C19 gene polymorphisms in patients with ischemic stroke treated with clopidogrel for prevention.
    Medicine, 2020, Volume: 99, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Recurrence; Retrospective Studies; Risk Factors; Secondary Prevention; Stroke

2020
Heritability Enrichment Implicates Microglia in Parkinson's Disease Pathogenesis.
    Annals of neurology, 2021, Volume: 89, Issue:5

    Topics: Chromatin; Chromosomes, Human, Pair 3; Clopidogrel; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Immunity, Cellular; Linkage Disequilibrium; Microglia; Monocytes; Multifactorial Inheritance; Parkinson Disease; Polymorphism, Single Nucleotide; Receptors, Purinergic P2Y12; Risk Assessment

2021
A genetic polymorphism in P2RY
    Scientific reports, 2021, 06-15, Volume: 11, Issue:1

    Topics: Animals; Cardiomyopathy, Hypertrophic; Cats; Clopidogrel; Genetic Predisposition to Disease; Genotype; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Purinergic P2Y1

2021
The risk of clopidogrel resistance is associated with ABCB1 polymorphisms but not promoter methylation in a Chinese Han population.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: Aged; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; DNA Methylation; Drug Resistance; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; Male; Middle Aged; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Serum Albumin; Sex Characteristics; Ticlopidine; Vascular System Injuries

2017
Effect of cytochrome P450 2C19 polymorphism on adverse cardiovascular events after drug-eluting stent implantation in a large Hakka population with acute coronary syndrome receiving clopidogrel in southern China.
    European journal of clinical pharmacology, 2018, Volume: 74, Issue:4

    Topics: Acute Coronary Syndrome; Adenosine; Aged; Asian People; Chi-Square Distribution; China; Clinical Decision-Making; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Gene Frequency; Genetic Predisposition to Disease; Hemorrhage; Heterozygote; Homozygote; Humans; Hypertension; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Precision Medicine; Retrospective Studies; Risk Factors; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome

2018
Analysis of the CYP2C19 genotype associated with bleeding in Serbian STEMI patients who have undergone primary PCI and treatment with clopidogrel.
    European journal of clinical pharmacology, 2018, Volume: 74, Issue:4

    Topics: Aged; Chi-Square Distribution; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Predisposition to Disease; Haplotypes; Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Percutaneous Coronary Intervention; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Retrospective Studies; Risk Factors; Serbia; ST Elevation Myocardial Infarction; Ticlopidine; Treatment Outcome

2018
Equilibrative nucleoside transporter 1 gene polymorphisms and clinical outcomes following acute coronary syndromes: findings from the PLATelet inhibition and patient Outcomes (PLATO) study.
    Platelets, 2019, Volume: 30, Issue:5

    Topics: Acute Coronary Syndrome; Biomarkers; Blood Platelets; Cause of Death; Clopidogrel; Equilibrative Nucleoside Transporter 1; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Prognosis; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome

2019
Response to clopidogrel and of the cytochrome CYP2C19 gene polymorphism.
    La Tunisie medicale, 2018, Volume: 96, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug-Related Side Effects and Adverse Reactions; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Genotyping Techniques; Hemorrhage; Heterozygote; Humans; Longitudinal Studies; Male; Middle Aged; Pharmacogenomic Testing; Polymorphism, Genetic; Tunisia

2018
Clopidogrel pharmacogenetics: associations between genotype and stent thrombosis risk in patients with stent placement.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2019, Volume: 20, Issue:1

    Topics: Aged; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Pilot Projects; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Stents

2019
Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention.
    Cardiovascular research, 2019, 08-01, Volume: 115, Issue:10

    Topics: Aged; Aged, 80 and over; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Coronary Thrombosis; Drug Resistance; Europe; Female; Genetic Association Studies; Genetic Predisposition to Disease; Hemorrhage; Homozygote; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Soluble Guanylyl Cyclase; Stents; Time Factors; Treatment Outcome

2019
Association of PON1 genotype and haplotype with susceptibility to coronary artery disease and clinical outcomes in dual antiplatelet-treated Han Chinese patients.
    European journal of clinical pharmacology, 2013, Volume: 69, Issue:8

    Topics: Aged; Aryldialkylphosphatase; Asian People; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Promoter Regions, Genetic; Ticlopidine; Treatment Outcome

2013
[Relationship between human platelet antigen-1 gene polymorphism and clopidogrel resistance in patients with coronary artery disease].
    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2013, Volume: 41, Issue:5

    Topics: Antigens, Human Platelet; Blood Platelets; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Genetic Predisposition to Disease; Humans; Integrin beta3; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine

2013
Impact of -455G/a polymorphism of the β-fibrinogen gene on platelet aggregation in patients with acute coronary syndrome.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2014, Volume: 20, Issue:3

    Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Female; Fibrinogen; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Assessment; Ticlopidine

2014
Association of P2Y12 gene promoter DNA methylation with the risk of clopidogrel resistance in coronary artery disease patients.
    BioMed research international, 2014, Volume: 2014

    Topics: Aged; Clopidogrel; Coronary Artery Disease; DNA Methylation; Drug Resistance; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Promoter Regions, Genetic; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine; Treatment Failure

2014
Clopidogrel significantly lowers the development of atherosclerosis in ApoE-deficient mice in vivo.
    Heart and vessels, 2016, Volume: 31, Issue:5

    Topics: Animals; Aorta, Thoracic; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Biomarkers; Chemokine CCL2; Clopidogrel; Disease Models, Animal; Disease Progression; E-Selectin; Gene Expression Regulation; Genetic Predisposition to Disease; Lipids; Lymphokines; Mice, Inbred C57BL; Mice, Knockout; P-Selectin; Phenotype; Plaque, Atherosclerotic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet-Derived Growth Factor; RNA, Messenger; Ticlopidine; Time Factors; Vascular Remodeling

2016
Cytochrome P450 CYP 2C19*2 Associated with Adverse 1-Year Cardiovascular Events in Patients with Acute Coronary Syndrome.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Activation, Metabolic; Acute Coronary Syndrome; Aged; Alleles; Angina Pectoris; Aspirin; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug Resistance; Drug Therapy, Combination; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prodrugs; Prognosis; Prospective Studies; Recurrence; Stents; Ticlopidine; Treatment Outcome

2015
Association between CYP2C19 Polymorphisms and Outcomes in Cerebral Endovascular Therapy.
    AJNR. American journal of neuroradiology, 2016, Volume: 37, Issue:1

    Topics: Adult; Aged; Alleles; Brain Ischemia; Cerebrovascular Disorders; Clopidogrel; Cytochrome P-450 CYP2C19; Embolization, Therapeutic; Endovascular Procedures; Female; Genetic Predisposition to Disease; Genotype; Humans; Longitudinal Studies; Male; Middle Aged; Polymorphism, Genetic; Prospective Studies; Stents; Ticlopidine

2016
[Association of CYP2C19 gene polymorphisms with long-term recurrent risk of ischemic stroke among ethnic Han Chinese from Fujian].
    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2015, Volume: 32, Issue:6

    Topics: Aged; Alleles; Asian People; Brain Ischemia; China; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Recurrence; Risk Factors; Sequence Analysis, DNA; Stroke; Ticlopidine; Time Factors

2015
P2Y12 Receptor Modulates Sepsis-Induced Inflammation.
    Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:5

    Topics: Acute Lung Injury; Animals; Blood Platelets; Clopidogrel; Cytokines; Genetic Predisposition to Disease; Leukocytes; Lung; Male; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; P-Selectin; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Pneumonia; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Sepsis; Signal Transduction; Ticlopidine

2016
Associations of P2Y12R gene polymorphisms with susceptibility to coronary heart disease and clinical efficacy of antiplatelet treatment with clopidogrel.
    Cardiovascular therapeutics, 2016, Volume: 34, Issue:6

    Topics: Aged; Blood Platelets; Case-Control Studies; Chromatography, High Pressure Liquid; Clopidogrel; Coronary Disease; Drug Resistance; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Haplotypes; Humans; Male; Middle Aged; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine; Treatment Outcome

2016
Platelet Activation and Clopidogrel Effects on ADP-Induced Platelet Activation in Cats with or without the A31P Mutation in MYBPC3.
    Journal of veterinary internal medicine, 2016, Volume: 30, Issue:5

    Topics: Adenosine Diphosphate; Animals; Carrier Proteins; Cat Diseases; Cats; Clopidogrel; Gene Expression Regulation; Genetic Predisposition to Disease; Genotype; Mutation; Platelet Activation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine

2016
Cardiovascular disease gets personal.
    Nature, 2009, Aug-20, Volume: 460, Issue:7258

    Topics: Anticoagulants; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Female; Genetic Predisposition to Disease; Genetic Testing; Genetic Variation; Genome-Wide Association Study; Genomics; Humans; Pharmacogenetics; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Warfarin

2009
Familial Takayasu's arteritis in female siblings.
    Rheumatology international, 2011, Volume: 31, Issue:6

    Topics: Adult; Aorta, Thoracic; Aspirin; Clopidogrel; Family Health; Female; Genetic Predisposition to Disease; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Renal Artery; Siblings; Takayasu Arteritis; Ticlopidine; Tomography, X-Ray Computed

2011
Impact of cytochrome P450 2C19*2 polymorphism on intra-stent thrombus after drug-eluting stent implantation in Japanese patients receiving clopidogrel.
    Circulation journal : official journal of the Japanese Circulation Society, 2011, Volume: 75, Issue:1

    Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Asian People; Cardiovascular Agents; Chi-Square Distribution; Cineangiography; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Japan; Logistic Models; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prosthesis Design; Risk Assessment; Risk Factors; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Tomography, Optical Coherence; Treatment Outcome

2011
The PLATO trial reveals further opportunities to improve outcomes in patients with acute coronary syndrome. Editorial on Serebruany. "Viewpoint: Paradoxical excess mortality in the PLATO trial should be independently verified" (Thromb Haemost 2011; 105.5)
    Thrombosis and haemostasis, 2011, Volume: 105, Issue:5

    Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials as Topic; Clinical Trials Data Monitoring Committees; Clopidogrel; Europe; Genetic Predisposition to Disease; Humans; Research Design; Survival Rate; Ticagrelor; Ticlopidine; Treatment Outcome; United States

2011
[Factors determining clinical effectiveness of clopidogrel and prognosis of patients with stable ischemic heart disease].
    Kardiologiia, 2011, Volume: 51, Issue:2

    Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; DNA; Female; Follow-Up Studies; Gene Frequency; Genetic Predisposition to Disease; Humans; Liver; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Treatment Outcome

2011
Standard- vs high-dose clopidogrel after percutaneous coronary intervention.
    JAMA, 2011, Jun-22, Volume: 305, Issue:24

    Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Reproducibility of Results; Risk; Ticlopidine

2011
Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis.
    JAMA, 2011, Oct-26, Volume: 306, Issue:16

    Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control Studies; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Cytochrome P-450 CYP2C19; DNA; Female; France; Genetic Predisposition to Disease; Genotype; Humans; Integrin beta3; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prognosis; Proton Pump Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine

2011
CYP2C19 gene variants cut-off levels for on-clopidogrel platelet aggregation.
    Thrombosis research, 2012, Volume: 129, Issue:2

    Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Genetic Variation; Humans; Japan; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prevalence; Thrombosis; Ticlopidine

2012
Relationship between cytochrome P450 2C19*2 polymorphism and stent thrombosis following percutaneous coronary intervention in Chinese patients receiving clopidogrel.
    The Journal of international medical research, 2011, Volume: 39, Issue:5

    Topics: Aged; Aged, 80 and over; Amplified Fragment Length Polymorphism Analysis; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; China; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Proportional Hazards Models; Ticlopidine

2011
Multiple gene polymorphisms predisposing to the prothrombotic state in an adolescent with acute myocardial infarction.
    Cardiovascular journal of Africa, 2012, Apr-12, Volume: 23, Issue:3

    Topics: Adolescent; Anticoagulants; Aspirin; Cholesterol Ester Transfer Proteins; Clopidogrel; Coronary Angiography; Electrocardiography; Fibrinogen; Genetic Predisposition to Disease; Heparin; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thrombosis; Ticlopidine

2012
Genetic testing in patients with acute coronary syndrome undergoing percutaneous coronary intervention: a cost-effectiveness analysis.
    Journal of thrombosis and haemostasis : JTH, 2013, Volume: 11, Issue:1

    Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Cerebrovascular Disorders; Clopidogrel; Computer Simulation; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Decision Support Techniques; Disease-Free Survival; Drug Costs; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Health Care Costs; Hemorrhage; Humans; Insurance, Health, Reimbursement; Kaplan-Meier Estimate; Markov Chains; Medicare; Models, Economic; Myocardial Infarction; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Predictive Value of Tests; Quality-Adjusted Life Years; Risk Assessment; Risk Factors; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; United States

2013
Cardiovascular risk among patients on clopidogrel anti-platelet therapy after placement of drug-eluting stents is modified by genetic variants in both the CYP2C19 and ABCB1 genes.
    Thrombosis and haemostasis, 2013, Volume: 109, Issue:4

    Topics: Aged; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chi-Square Distribution; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Proportional Hazards Models; Prosthesis Design; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome

2013
Clopidogrel resistance marks recurrent risks.
    Circulation, 2004, Jun-29, Volume: 109, Issue:25

    Topics: Aged; Bibliometrics; Cardiology; Clopidogrel; Cohort Studies; Coronary Restenosis; Drug Resistance; Estrogen Receptor alpha; Female; Folic Acid; Genetic Predisposition to Disease; Heart Diseases; Humans; Male; Mass Screening; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Platelet Aggregation Inhibitors; Predictive Value of Tests; Recurrence; Risk; Stents; Ticlopidine; Vitamin B 12; Vitamin B 6

2004
Association of a functional polymorphism in the clopidogrel target receptor gene, P2Y12, and the risk for ischemic cerebrovascular events in patients with peripheral artery disease.
    Stroke, 2005, Volume: 36, Issue:7

    Topics: Aged; Alleles; Aspirin; Brain Ischemia; Cerebrovascular Circulation; Clopidogrel; Cohort Studies; Exons; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heterozygote; Humans; Ischemia; Membrane Proteins; Middle Aged; Mutation; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Genetic; Prevalence; Proportional Hazards Models; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stroke; Ticlopidine; Time Factors; Treatment Outcome

2005
Impact of PlA polymorphism of platelet GP IIb/IIIa receptors on clinical course during long-term LVAD support is independent of type of LVAD.
    The Annals of thoracic surgery, 2006, Volume: 82, Issue:3

    Topics: Anticoagulants; Antigens, Human Platelet; Aspirin; Clopidogrel; Equipment Design; Genetic Predisposition to Disease; Genotype; Heart-Assist Devices; Hemorrhagic Disorders; Humans; Incidence; Integrin beta3; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Postoperative Complications; Thromboembolism; Thrombophilia; Ticlopidine

2006