clopidogrel has been researched along with Disease Models, Animal in 122 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.82) | 18.7374 |
| 1990's | 9 (7.38) | 18.2507 |
| 2000's | 40 (32.79) | 29.6817 |
| 2010's | 61 (50.00) | 24.3611 |
| 2020's | 11 (9.02) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Cabral, FL; da Silva, JLG; de Andrade, CM; Doleski, PH; Ebone, RDS; Jantsch, MH; Leal, DBR; Manzoni, AG; Passos, DF; Schetinger, MRC; Soares, ABU; Viana, AR | 1 |
| Foerch, C; Lieschke, F; Schaefer, JH; van Leyen, K; Wang, X; Zheng, Y | 1 |
| Heo, TH; Jeong, YJ; Lee, HR; Park, KY | 1 |
| Chen, L; He, W; Jing, F; Long, T; Qin, G; Zhang, D; Zhang, Y; Zhou, J | 1 |
| Cao, X; Gu, J; Li, X; Liu, P; Miao, Y; Sun, D; Xu, Z; Zhang, J | 1 |
| Gounis, MJ; Henkes, H; King, RM; Langan, ET; Puri, AS; Raskett, CM; Ughi, GJ | 1 |
| Choi, SG; Kang, JW; Kim, DW; Kim, SK; Shin, HJ; Song, HJ; Yi, YY | 1 |
| Kreutz, RP | 1 |
| Ashour, RH; Daba, MY; El Banna, FM; Khalaf, NEA; Mosaad, YM; Youssef, MY | 1 |
| Korish, AA | 1 |
| Fu, W; Hu, X; Jiang, H; Ma, R; Yang, J; Zhang, J | 1 |
| Gerwins, P; Heindryckx, F; Kopsida, M; Pavlović, N | 1 |
| Cai, Y; Chen, S; Du, C; Gao, Y; Lai, W; Qin, C; Yang, C; Zhou, J | 1 |
| Baiwir, D; Bouznad, N; Delierneux, C; Delvenne, P; Dibato Epoh, J; Lancellotti, P; Mazzucchelli, G; Oury, C; Rahmouni, S; Servais, L; Wéra, O | 1 |
| Li, L; Li, Y; Lu, N; Meng, F; Wei, Q; Xu, Y; Yuan, J; Zhang, S; Zheng, X | 1 |
| Chen, Y; Dong, P; Duan, Y; Gao, X; Han, J; Li, Q; Li, X; Qian, K; Wang, Y; Wei, Z; Yang, X; Zhang, S; Zhao, B; Zhao, D; Zhu, Y | 1 |
| Badimon, L; Ben-Aicha, S; Capdevila, A; Carlsson, L; Carreras, F; Casani, L; Gutiérrez, M; Hidalgo, A; Lambert, C; Mendieta, G; Pons-Lladó, G; Vilahur, G | 1 |
| Chaparro, E; Fedorova, E; Griffin, A; Hauck, EF; Holmes, C; Manson, RJ | 1 |
| Choi, Y; Nguyen, TVT; Park, HS; Shin, YS; Suh, DH; Trinh, HKT | 1 |
| Cui, W; Du, D; Hu, X; Shi, H; Sun, L; Tian, J; Yu, T; Zhang, X | 1 |
| Ensminger, SM; Heim, C; Khan, MA; Kuckhahn, A; Nicolls, MR; Ramsperger-Gleixner, M; Stamminger, T; von Silva-Tarouca, B; Weyand, M | 1 |
| Cho, O; Heo, TH; Kim, HS; Park, KY | 1 |
| Anisimova, VA; Divaeva, LN; Kucheryavenko, AF; Kuz'menko, TA; Morkovnik, AS; Sirotenko, VS; Spasov, AA | 1 |
| Akhilesh, R; Chow, VTK; Malayer, JR; Maram, P; Pulavendran, S; Rudd, JM; Teluguakula, N; Thomas, PG | 1 |
| Bai, R; Gu, J; Guo, Y; Ren, T; Wang, Y; Yao, H | 1 |
| Cooley, BC; Herrera, AJ | 1 |
| Guidotti, LG; Iannacone, M; Sitia, G | 1 |
| Amagase, K; Hara, D; Izuhara, C; Kojo, M; Momode, T; Takayama, S; Takeuchi, K | 1 |
| Ahn, YS; Bidot, C; Horstman, LL; Johansen, ME; Jy, W | 1 |
| Charles, AL; Fabre, JE; Geny, B; Gross, S; Gurney, ME; Ludwig, S; Meilhac, O; Slimani, F; Stefansson, K; Tilly, P | 1 |
| Coimbra, LS; Muscará, MN; Rossa, C; Spolidorio, LC; Steffens, JP | 1 |
| Abe, K; Deguchi, K; Ikeda, Y; Kono, S; Kurata, T; Liu, N; Liu, W; Omote, Y; Yamashita, T | 1 |
| Chintala, M; Keohane, C; Li, Q; Ni, W; O'Neill, K; Shang, J; Wang, M; Wei, H | 1 |
| Giachini, FR; Inscho, EW; Leite, R; Lima, VV; Osmond, DA; Tostes, RC; Webb, RC | 1 |
| Darbousset, R; Dignat-George, F; Dubois, C; Mezouar, S; Panicot-Dubois, L | 1 |
| Bergmeier, W; Getz, TM; Mackman, N; Monroe, D; Petrich, BG; Piatt, R | 1 |
| Amagase, K; Hashimoto, E; Itayama, M; Izuhara, C; Takayama, S; Takeuchi, K | 1 |
| Brands, X; de Stoppelaar, SF; Roelofs, JJ; Schouten, M; Schultz, MJ; van den Boogaard, FE; van der Poll, T; van't Veer, C | 1 |
| Bao, XC; Chen, H; Fang, YQ; Ma, J; Wang, FF; You, P; Yuan, HR | 1 |
| Goligorsky, MS; Hohenstein, B; Hugo, CP; Lerea, KM; Nieswandt, B; Schwarzenberger, C; Sradnick, J | 1 |
| Birnbaum, GD; Birnbaum, Y; Nanhwan, MK; Nylander, S; Perez-Polo, JR; Ye, Y | 1 |
| Ensminger, SM; Gebhardt, J; Heim, C; Jacobi, J; Ramsperger-Gleixner, M; Weyand, M | 1 |
| Chi, Q; Gachet, C; Huang, L; Lei, D; Mangin, PH; Tang, C; Wang, G; Wang, Y; Zheng, Y; Zhu, L | 1 |
| Chu, L; Desai, K; Gutstein, DE; Kurowski, S; Seiffert, D; Wang, X; Wu, W; Zhou, X | 1 |
| Chaudhary, N; Gemmete, JJ; Li, P; Pandey, AS; Thompson, BG; Xi, G; Zhang, C | 1 |
| Chen, YE; Eitzman, DT; Hollenberg, PF; Lauver, DA; Osawa, Y; Sun, D; Wang, H; Zhang, H | 1 |
| Dessing, MC; Emal, D; Florquin, S; Jansen, MP; Roelofs, JJ; Teske, GJ | 1 |
| Fichter, AM; Mitchell, DA; Mücke, T; Ritschl, LM; Robitzky, LK; Wagenpfeil, S; Wolff, KD | 1 |
| Akhmedov, A; Beer, JH; Bonetti, NR; Camici, GG; Gaul, DS; Glanzmann, M; Keller, S; Lüscher, TF; Matter, CM; Reiner, MF; Ruf, W; Savarese, G; Stivala, S; Yang, Z; Zhu, C | 1 |
| Arumugham, S; Payanam Ramachandra, U; Shenoy, SJ | 1 |
| Garcia-Rinaldi, RF; Macdonald, RJ; McKellar, SH; Schaff, HV; Sundt, TM; Thompson, JL | 1 |
| Helsen, S; Hoylaerts, MF; Lijnen, HR | 1 |
| Farhan, S; Glogar, D; Gyöngyösi, M; Hemetsberger, H; Hemetsberger, R; Huber, K; Pavo, I; Petrasi, Z; Posa, A; Sperker, W; Strehblow, C | 1 |
| Crain, EJ; Hua, J; Rehfuss, R; Schumacher, WA; Watson, CA; Wong, PC | 1 |
| Dang-Heine, C; Dechend, R; Deiner, C; Loddenkemper, C; Martens, H; Pels, K; Rauch, U; Rosenthal, P; Schultheiss, HP; Schwimmbeck, PL | 1 |
| Afek, A; George, J; Keren, G; Kogan, E; Maysel-Auslender, S; Mor, A; Regev, E; Rubinstein, A | 1 |
| Berntsson, P; Björkman, JA; van Giezen, JJ; Zachrisson, H | 1 |
| Bahcivan, M; Erenler, BH; Gol, MK; Keceligil, HT; Kolbakir, F; Yucel, S | 1 |
| Kloppenburg, G | 1 |
| Abele-Ohl, S; Eckl, S; Ensminger, SM; Heim, C; Hoffmann, J; Ramsperger-Gleixner, M; Weyand, M | 1 |
| Brainard, BM; Budsberg, SC; Kleine, SA; Papich, MG | 1 |
| Bachelot-Loza, C; Dizier, B; Emmerich, J; Gaussem, P; Godier, A; Grelac, F; Hindy-François, C; Le Bonniec, B; Samama, CM | 1 |
| Huang, Y; Khalil, M; Penn, MS; van Giezen, JJ; Wang, K; Wiktor, D; Zhou, X | 1 |
| Batteux, F; Blanco, P; Bordes, C; Douchet, I; Duffau, P; Goulvestre, C; Lazaro, E; Moreau, JF; Nicco, C; Pellegrin, JL; Richez, C; Seneschal, J; Viallard, JF; Weil, B | 1 |
| Abduljalil, AM; Bergdall, VK; Christoforidis, GA; Khanna, S; Knopp, MV; Koch, RM; Kontzialis, MS; Mohammad, Y; Rink, C; Roy, S; Sen, CK; Slivka, AP | 1 |
| Dart, AM; Du, XJ; Gao, XM; Head, GA; Kiriazis, H; Liu, Y; Lobo, A; Shan, L | 1 |
| Bussel, J; Chen, J; Dangas, G; Diacovo, T; Magallon, J; Rabbani, L; Yang, J | 1 |
| Gachet, C; Hechler, B | 1 |
| Batteux, F; Borderie, D; Chéreau, C; Dinh-Xuan, AT; Gobeaux, C; Hu, H; Kavian, N; Marut, W; Nicco, C; Weill, B | 1 |
| Hirata, K; Momose, A; Nakajima, K; Sasaki, N; Shinohara, M; Takeda, M; Tawa, H; Yamashita, T | 1 |
| Buschmann, IR; Busjahn, A; Duelsner, A; Gatzke, N; Glaser, J; Hillmeister, P; Lee, EJ; Lehmann, K; Li, M; Meyborg, H; Nagorka, S; Persson, AB; Stawowy, P; Urban, D | 1 |
| Daemen, MJ; Gabriels, K; Gijbels, MJ; Heeneman, S; Hoving, S; Pol, JF; Russell, NS; Stewart, FA; te Poele, JA | 1 |
| Dela Cadena, RA; Garcia, AE; Kunapuli, SP; Mada, SR; Rico, MC | 1 |
| Abegunewardene, N; Gori, T; Horstick, G; Kreitner, KF; Lehr, HA; Münzel, T; Schmidt, KH; Schreiber, LM; Vosseler, M | 1 |
| Hamilton, JR; Jackson, SP; Lee, H; Mountford, JK; Sturgeon, SA | 1 |
| Greenhill, C | 1 |
| Cooley, BC | 1 |
| Henderson, SO; Levine, M; Markland, FS; McCormick, T; Swenson, S; Thomas, SH | 1 |
| Ahn, Y; Cho, JG; Hong, YJ; Jeong, MH; Kang, JC; Kim, JH; Kim, JM; Kim, KH; Lee, KH; Lim, KS; Park, DS; Park, HW; Park, JC; Park, KH; Sim, DS; Yoon, HJ; Yoon, NS | 1 |
| Fishbein, MC; Goldhaber, SZ; Sobieszczyk, P | 1 |
| Albiero, R; Colombo, A; Corvaja, N; Di Mario, C; Falotico, R; Stankovic, G; Takagi, T; Toutouzas, K | 1 |
| Cazenave, JP; Freund, M; Gachet, C; Lenain, N; Léon, C | 1 |
| Alex, M; Eckly, A; Engelmann, B; Gachet, C; Klocke, A; Leon, C; Moosbauer, C; Morgenstern, E; Spannagl, M | 1 |
| Wang, X; Xu, L | 1 |
| Akbas, MH; Berki, KT; Bulbul, S; Kanko, M; Maral, H; Omay, O; Ozden, M; Yavuz, S | 1 |
| Alberti, PF; Del Soldato, P; Gresele, P; Minuz, P; Momi, S; Pitchford, SC | 1 |
| Fernández-Sánchez, R; López-Farré, A; Luisa Maestro, M; Macaya, C; Mateos-Cáceres, PJ; Molero, L; Rodríguez, E; Silva, J | 1 |
| Andre, P; Conley, PB; Phillips, DR; Sinha, U | 1 |
| Driscoll, E; Hong, TT; Huang, J; Lucchesi, BR | 1 |
| Bode, C; Buschmann, IR; Grundmann, S; Hoefer, IE; Meder, B; Piek, JJ; Schirmer, S; van Royen, N | 1 |
| Claussen, CD; Dinkelborg, LM; Duda, SH; Laule, M; Muschick, P; Reddig, F; Tepe, G; Tielemans, H; Wehrmann, M | 1 |
| Berg, O; Bierbach, B; Darius, H; Heimann, A; Horstick, G; Kempski, O; Münzel, T; Vahl, CF | 1 |
| Demirtaş, E; Ide, T; Işik, E; Iyisoy, A; Köz, C; Kurşaklioğlu, H; Töre, HF; Yildirim, V | 1 |
| Brooks, JM; Crandall, DL; Hennan, JK; Leik, CE; Morgan, GA; Schaub, RG; Shaw, GD; Swillo, RE; Vlasuk, GP | 1 |
| Abele, S; Ensminger, SM; Fischlein, T; Harig, F; Hiemann, NE; Weyand, M; Wollin, M | 1 |
| Acil, C; Kanko, M; Maral, H; Ozden, M | 1 |
| Li, M; Ren, H; Zhang, Y; Zhu, X | 1 |
| Crain, EJ; Knabb, RM; Lam, PY; Quan, ML; Watson, CA; Wexler, RR; Wong, PC | 1 |
| Badimon, L; Padró, T; Pena, E; Vilahur, G | 1 |
| Alexander, S; Bryant, J; Buckman, BO; da Cunha, V; Dole, WP; Fitch, RM; Islam, I; Mallari, C; Martin-McNulty, B; Morser, J; Post, JM; Subramanyam, B; Sullivan, ME; Vergona, R; Vincelette, J; Wang, YX; Yuan, S | 1 |
| Bostwick, JS; Crain, EJ; Hua, J; Jiang, X; Ogletree, ML; Rehfuss, R; Schumacher, WA; Watson, CA; Wong, PC | 1 |
| Badimon, L; Casaní, L; Vilahur, G | 1 |
| Graciano, ML; Jackson, K; Kobori, H; Navar, LG; Nishiyama, A; Ortiz, RM; Prieto-Carrasquero, MC; Seth, DM | 1 |
| Badenhorst, PN; Brown, S; Bruwer, A; De Meyer, SF; Deckmyn, H; Janssens, S; Lamprecht, S; Meiring, M; Pieters, H; Roodt, J; Staelens, S; Vanhoorelbeke, K | 1 |
| Baxi, SM; Karnicki, K; Leadley, RJ; McBane, RD; Wysokinski, W | 1 |
| Koellnberger, M; Konrad, I; Lorenz, R; Massberg, S; Orschiedt, L; Sauer, S; Schulz, C; Walter, U | 1 |
| FitzGerald, GA | 1 |
| Baxi, S; Karnicki, K; Leadley, RJ; McBane, RD; Peterson, T; Wysokinski, W | 1 |
| Hirata, Y; Nakashima, M; Uematsu, T; Umemura, K | 1 |
| Anderson, HV; Buja, LM; Ferguson, JJ; Maffrand, JP; Ober, JC; Willerson, JT; Yao, SK | 1 |
| Beretz, A; Cazenave, JP; Freund, M; Gachet, C; Mantz, F; Meyer, L; Mulvihill, J; Nicolini, P | 1 |
| Eigler, NL; Forrester, JS; Frimerman, A; Herbert, JM; Kaul, S; Litvack, F; Makkar, RR; Nakamura, M; Shah, PK | 1 |
| Boneu, B; Cazenave, JP; Freund, M; Léger, P; Magues, JP | 1 |
| Asai, F; Inoue, T; Koike, H; Ogawa, T; Sugidachi, A | 1 |
| Driscoll, E; Hasa, AA; Lucchesi, BR; Normolle, D; Schmaier, AH; Warnock, M; Werns, SW | 1 |
| Bergerat, JP; Cazenave, JP; Céraline, J; Chenard, MP; Deplanque, G; Klein-Soyer, C; Mah-Becherel, MC | 1 |
| Bernat, A; Herbert, JM; Maffrand, JP | 1 |
| Bailliart, O; Bonneau, M; Bonnin, P; Caen, JP; Drouet, LO; Maffrand, JP; Mazoyer, E; Pignaud, G; Samama, CM; Viars, P | 1 |
| Maruyama, S; Uchiyama, S; Yamazaki, M | 1 |
| Cazenave, JP; Freund, M; Mantz, F | 1 |
| Bernat, A; Cazenave, JP; Defreyn, G; Delebassée, D; Gordon, JL; Maffrand, JP | 1 |
3 review(s) available for clopidogrel and Disease Models, Animal
| Article | Year |
|---|---|
Sirolimus-eluting stents: a review of experimental and clinical findings.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Animals; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Restenosis; Disease Models, Animal; Drug Delivery Systems; Follow-Up Studies; Humans; Immunosuppressive Agents; Injections, Intramuscular; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Rats; Sirolimus; Stents; Swine; Thrombosis; Ticlopidine; Time Factors; Ultrasonography, Interventional | 2002 |
Therapeutic approaches in arterial thrombosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Atherosclerosis; Blood Platelets; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; Disease Progression; Fibrinolytic Agents; Humans; Mice; Models, Biological; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Risk; Signal Transduction; Thrombosis; Ticlopidine; Time Factors | 2005 |
Translational therapeutics at the platelet vascular interface. Summary.
Topics: Angina, Unstable; Animals; Aspirin; Blood Platelets; Clopidogrel; Disease Models, Animal; Drug Evaluation, Preclinical; Education, Medical, Continuing; Humans; Mice; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Secondary Prevention; Sensitivity and Specificity; Survival Analysis; Ticlopidine; Treatment Outcome | 2008 |
119 other study(ies) available for clopidogrel and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Effects of clopidogrel bisulfate on B16-F10 cells and tumor development in a murine model of melanoma.
Topics: Animals; Clopidogrel; Disease Models, Animal; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Skin Neoplasms; Tumor Microenvironment | 2023 |
Dual Antiplatelet Therapy Increases Hemorrhagic Transformation Following Thrombolytic Treatment in Experimental Stroke.
Topics: Animals; Aspirin; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; Drug Therapy, Combination; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Intracranial Hemorrhages; Male; Mice; Platelet Aggregation Inhibitors; Platelet Function Tests; Secondary Prevention; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator | 2019 |
Comparative effectiveness of different antiplatelet agents at reducing TNF-driven inflammatory responses in a mouse model.
Topics: Animals; Cilostazol; Clopidogrel; Disease Models, Animal; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Platelet Aggregation Inhibitors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2020 |
P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine.
Topics: Adenine; Animals; Clopidogrel; Disease Models, Animal; Mice; Microglia; Migraine Disorders; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Trigeminal Nuclei; Valerates | 2019 |
A Pharmacodynamic Study of CN-218, a Novel Antiplatelet and Antithrombotic Agent Primarily Targeting the P2Y
Topics: Animals; Blood Coagulation; Blood Platelets; Carrageenan; Clopidogrel; Cyclic AMP; Disease Models, Animal; Fibrinolytic Agents; Hemorrhage; Male; Mice; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Rats, Wistar; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis | 2020 |
Acute Thrombus Burden on Coated Flow Diverters Assessed by High Frequency Optical Coherence Tomography.
Topics: Acute Disease; Animals; Aspirin; Clopidogrel; Coated Materials, Biocompatible; Disease Models, Animal; Platelet Aggregation Inhibitors; Stents; Swine; Thrombosis; Tomography, Optical Coherence | 2020 |
Preventive Effects of Neuroprotective Agents in a Neonatal Rat of Photothrombotic Stroke Model.
Topics: Animals; Animals, Newborn; Aspirin; Brain Ischemia; Clopidogrel; Disease Models, Animal; Inflammation; Neuroprotective Agents; Rats; Rose Bengal; Stroke; Ubiquinone | 2020 |
IL-1R (Interleukin-1 Receptor) Signaling and Attenuated Hepatic CYP (Cytochrome P450) 2C Expression: Explanation for Higher Rate of Clopidogrel Resistance in Patients With Diabetes Mellitus?
Topics: Animals; Clopidogrel; Cytochrome P-450 Enzyme System; Diabetes Mellitus; Diet; Disease Models, Animal; Humans; Mice; Obesity; Receptors, Interleukin-1 | 2020 |
Clopidogrel combats neuroinflammation and enhances learning behavior and memory in a rat model of Alzheimer's disease.
Topics: Acetylcholinesterase; Aluminum Chloride; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Clopidogrel; Cytokines; Disease Models, Animal; Gene Expression; Hippocampus; Male; Maze Learning; Neuroprotective Agents; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Recognition, Psychology; RNA, Messenger; Signal Transduction | 2020 |
Clopidogrel Prophylaxis Abates Myocardial Ischemic Injury and Inhibits the Hyperlipidemia-Inflammation Loop in Hypercholestrolemic Mice.
Topics: Animals; Aspirin; Clopidogrel; Disease Models, Animal; Humans; Hypercholesterolemia; Hyperlipidemias; Inflammation; Male; Mice; Myocardial Ischemia; Platelet Aggregation Inhibitors | 2020 |
TMAO: a potential mediator of clopidogrel resistance.
Topics: Animals; Biomarkers; Blood Platelets; Clopidogrel; Coronary Artery Disease; Disease Models, Animal; Drug Resistance; Male; Methylamines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Rats | 2021 |
Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment.
Topics: Animals; Blood Platelets; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Clopidogrel; Disease Models, Animal; Endothelial Cells; Female; Hepatic Stellate Cells; Humans; Liver Neoplasms; Male; Mice; Signal Transduction; Tumor Microenvironment | 2021 |
Critical Role of P2Y
Topics: Adenosine; Animals; Autoimmune Diseases; Cell Differentiation; Cells, Cultured; Clopidogrel; Colitis; Diabetes Mellitus, Experimental; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Interleukin-17; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Th17 Cells; Ticagrelor; Ticlopidine; Trinitrobenzenesulfonic Acid | 2017 |
Platelets contribute to the initiation of colitis-associated cancer by promoting immunosuppression.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Blood Platelets; CD8-Positive T-Lymphocytes; Cells, Cultured; Clopidogrel; Colitis; Colon; Colorectal Neoplasms; Disease Models, Animal; Immune Tolerance; Lymphocytes, Tumor-Infiltrating; Male; Mice, Inbred C57BL; Myeloid Cells; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Serum Amyloid A Protein; Tumor Escape | 2018 |
Synthesis of a Novel Series of Amino Acid Prodrugs Based on Thienopyridine Scaffolds and Evaluation of Their Antiplatelet Activity.
Topics: Adenosine Diphosphate; Animals; Bleeding Time; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Molecular Structure; Platelet Aggregation; Prasugrel Hydrochloride; Prodrugs; Rats; Thienopyridines; Ticlopidine | 2018 |
NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Blood Coagulation; Capsules; Carrageenan; Cell Adhesion; Clopidogrel; Disease Models, Animal; Drugs, Chinese Herbal; Endothelium, Vascular; Fibrinolytic Agents; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Liver; Male; Mice, Inbred BALB C; Monocytes; Oxidative Stress; Platelet Aggregation Inhibitors; Powders; Signal Transduction; Tail; THP-1 Cells; Thrombosis | 2018 |
P2Y12 antagonists and cardiac repair post-myocardial infarction: global and regional heart function analysis and molecular assessments in pigs.
Topics: AMP-Activated Protein Kinases; Animals; Clopidogrel; Disease Models, Animal; Echocardiography; Fibrosis; Heart Ventricles; Magnetic Resonance Imaging, Cine; Myocardial Infarction; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Stroke Volume; Sus scrofa; Ticagrelor; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2018 |
Thromboembolic Events with Enterprise Versus Pipeline: Porcine In Vivo Experiment.
Topics: Angiography, Digital Subtraction; Animals; Brain Ischemia; Carotid Artery, Common; Clopidogrel; Disease Models, Animal; Embolization, Therapeutic; Feasibility Studies; Graft Occlusion, Vascular; Intracranial Aneurysm; Platelet Aggregation Inhibitors; Prosthesis Design; Prosthesis Failure; Stents; Sus scrofa; Swine; Thromboembolism | 2019 |
Characterization of cysteinyl leukotriene-related receptors and their interactions in a mouse model of asthma.
Topics: Acetates; Animals; Asthma; Clopidogrel; Cyclohexanecarboxylic Acids; Cyclopropanes; Disease Models, Animal; Drug Therapy, Combination; Eosinophils; Female; Inflammation; Interleukins; Leukotriene Antagonists; Mice; Mice, Inbred BALB C; Ovalbumin; Phthalic Acids; Purinergic P2Y Receptor Antagonists; Quinolines; Receptors, Leukotriene; Receptors, Purinergic P2Y12; Sulfides; Th2 Cells | 2019 |
P2Y12 regulates microglia activation and excitatory synaptic transmission in spinal lamina II neurons during neuropathic pain in rodents.
Topics: Adenine; Animals; Clopidogrel; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Neuralgia; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; rho GTP-Binding Proteins; Signal Transduction; Spinal Cord; Spinal Cord Dorsal Horn; Spinal Cord Injuries; Spinal Nerves; Synaptic Transmission; Valerates | 2019 |
Preservation of Microvascular Integrity in Murine Orthotopic Tracheal Allografts by Clopidogrel.
Topics: Allografts; Animals; Clopidogrel; Disease Models, Animal; Graft Rejection; Humans; Injections, Intraperitoneal; Ischemia; Lung Transplantation; Mice; Microvessels; Platelet Aggregation Inhibitors; Trachea; Transplantation, Homologous; Treatment Outcome | 2019 |
A Comparison of the Anti-Inflammatory Effects of Four Combined Statin and Antiplatelet Therapies on Tumor Necrosis Factor-Mediated Acute Inflammation in vivo.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cilostazol; Clopidogrel; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipopolysaccharides; Male; Mice; Platelet Aggregation Inhibitors; Pravastatin; Rosuvastatin Calcium; Treatment Outcome; Tumor Necrosis Factor-alpha | 2019 |
Antithrombotic Activity of a Novel Diazepino[1,2-α] Benzimidazole Derivative on Arterial Thrombosis Model in Rats without Concomitant Pathology and in Rats with Experimental Myocardial Infarction.
Topics: Animals; Animals, Outbred Strains; Aspirin; Azepines; Benzimidazoles; Blood Coagulation Tests; Chlorides; Clopidogrel; Disease Models, Animal; Ferric Compounds; Fibrinolytic Agents; Male; Myocardial Infarction; Platelet Aggregation; Rats; Thrombosis | 2019 |
Combination Therapy Targeting Platelet Activation and Virus Replication Protects Mice against Lethal Influenza Pneumonia.
Topics: Animals; Clopidogrel; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Extracellular Traps; Female; Histones; Influenza A Virus, H1N1 Subtype; Lung; Mice; Neutrophils; Orthomyxoviridae Infections; Oseltamivir; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Pneumonia, Viral; Thrombophilia; Virus Replication | 2019 |
Enhanced Platelet Response to Clopidogrel in Zucker Diabetic Fatty Rats due to Impaired Clopidogrel Inactivation by Carboxylesterase 1 and Increased Exposure to Active Metabolite.
Topics: Administration, Oral; Animals; Blood Platelets; Carboxylesterase; Clopidogrel; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Zucker | 2019 |
Cross-modulatory effects of clopidogrel and heparin on platelet and fibrin incorporation in thrombosis.
Topics: Animals; Anticoagulants; Blood Coagulation; Blood Platelets; Clopidogrel; Disease Models, Animal; Drug Interactions; Fibrin; Heparin; Male; Mice; Mice, Inbred C57BL; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine; Venous Thrombosis | 2013 |
Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma.
Topics: Animals; Aspirin; Blood Platelets; Carcinoma, Hepatocellular; CD8-Positive T-Lymphocytes; Cell Proliferation; Clopidogrel; Disease Models, Animal; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Mice; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel--prophylactic effect of antiulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Drug Synergism; Histamine H2 Antagonists; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Rats; Stomach Ulcer; Ticlopidine | 2014 |
Red cell-derived microparticles (RMP) as haemostatic agent.
Topics: Adenosine Diphosphate; Animals; Bleeding Time; Blood Coagulation Disorders; Busulfan; Cell Separation; Cell-Derived Microparticles; Clopidogrel; Disease Models, Animal; Erythrocytes; Flow Cytometry; Hemostasis; Humans; Male; Platelet Aggregation; Rabbits; Rats; Rats, Sprague-Dawley; Thrombelastography; Thrombin; Thrombocytopenia; Thromboplastin; Ticlopidine | 2013 |
Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence.
Topics: Acrylamides; Animals; Blood Platelets; Clopidogrel; Dinoprostone; Disease Models, Animal; Mice; Plaque, Atherosclerotic; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Prostaglandin E, EP3 Subtype; Sulfones; Thrombosis; Ticlopidine | 2014 |
Antiplatelet drugs reduce the immunoinflammatory response in a rat model of periodontal disease.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Aspirin; Clopidogrel; Collagen; Connective Tissue; Disease Models, Animal; Gingiva; Inflammation Mediators; Male; Mandibular Diseases; Periodontitis; Peroxidase; Platelet Aggregation Inhibitors; Platelet Factor 4; Random Allocation; Rats; Rats, Sprague-Dawley; Ticlopidine | 2014 |
Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation.
Topics: Animals; Antigens; Aspirin; Cerebrovascular Circulation; Cilostazol; Clopidogrel; Disease Models, Animal; Endothelium; Fibrinolytic Agents; Male; Matrix Metalloproteinase 9; Neovascularization, Pathologic; Nerve Tissue Proteins; Pericytes; Proteoglycans; Rats; Rats, Inbred SHR; Stroke; Tetrazoles; Ticlopidine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
A novel approach to assess the spontaneous gastrointestinal bleeding risk of antithrombotic agents using Apc(min/+) mice.
Topics: Age Factors; Animals; Benzimidazoles; Clopidogrel; Dabigatran; Disease Models, Animal; Drug Evaluation, Preclinical; Fibrinolytic Agents; Gastrointestinal Hemorrhage; Genes, APC; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Pyrazoles; Pyridines; Pyridones; Risk Factors; Ticlopidine; Warfarin | 2014 |
Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats.
Topics: Adenosine Diphosphate; Animals; Aorta; Blood Pressure; Clopidogrel; Disease Models, Animal; Endothelium, Vascular; Gene Expression; Hypertension; Male; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Rats; Receptors, Purinergic P2Y; Thionucleotides; Ticlopidine; Vascular Remodeling; Vasoconstriction; Vasodilation | 2014 |
Inhibition of platelet activation prevents the P-selectin and integrin-dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasis in vivo.
Topics: Animals; Blood Coagulation; Blotting, Western; Cell-Derived Microparticles; Clopidogrel; Disease Models, Animal; Flow Cytometry; Fluorescent Antibody Technique; Integrins; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; P-Selectin; Pancreatic Neoplasms; Platelet Activation; Platelet Aggregation Inhibitors; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thromboplastin; Thrombosis; Ticlopidine; Tumor Cells, Cultured | 2015 |
Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition.
Topics: Animals; Bleeding Time; Blood Coagulation; Blood Platelets; Clopidogrel; Disease Models, Animal; Factor IX; Fibrin; Hemostasis; Intravital Microscopy; Laser Therapy; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Microscopy, Video; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Saphenous Vein; Talin; Thromboplastin; Ticlopidine; Time Factors; Vascular System Injuries | 2015 |
Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Male; Platelet Aggregation Inhibitors; Quinolones; Rats, Sprague-Dawley; Stomach Ulcer; Ticlopidine; Treatment Outcome | 2014 |
Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia.
Topics: Animals; Antithrombin III; Clopidogrel; Cytokines; Disease Models, Animal; Mice; Peptide Hydrolases; Pneumonia, Pneumococcal; Purinergic P2Y Receptor Antagonists; Streptococcus pneumoniae; Thrombocytopenia; Ticlopidine | 2015 |
Clopidogrel reduces the inflammatory response of lung in a rat model of decompression sickness.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Clopidogrel; Cytokines; Decompression Sickness; Disease Models, Animal; Immunohistochemistry; Leukocytes; Lung; Male; Organ Size; Platelet Aggregation Inhibitors; Platelet Membrane Glycoprotein IIb; Pressure; Rats, Sprague-Dawley; Ticlopidine; Treatment Outcome | 2015 |
Platelets are relevant mediators of renal injury induced by primary endothelial lesions.
Topics: Acute Kidney Injury; Animals; Blood Platelets; Cell-Derived Microparticles; Clopidogrel; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Male; Mice, Inbred C57BL; P-Selectin; Platelet Activation; Ticlopidine | 2015 |
Ticagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction.
Topics: Adenosine; Administration, Oral; Animals; Apoptosis; Cardiotonic Agents; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Injections, Intraperitoneal; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Purinergic P2Y Receptor Antagonists; Rats, Sprague-Dawley; Signal Transduction; Ticagrelor; Ticlopidine; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2015 |
Clopidogrel significantly lowers the development of atherosclerosis in ApoE-deficient mice in vivo.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Biomarkers; Chemokine CCL2; Clopidogrel; Disease Models, Animal; Disease Progression; E-Selectin; Gene Expression Regulation; Genetic Predisposition to Disease; Lipids; Lymphokines; Mice, Inbred C57BL; Mice, Knockout; P-Selectin; Phenotype; Plaque, Atherosclerotic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet-Derived Growth Factor; RNA, Messenger; Ticlopidine; Time Factors; Vascular Remodeling | 2016 |
Standardization of a well-controlled in vivo mouse model of thrombus formation induced by mechanical injury.
Topics: Animals; Aorta; Clopidogrel; Disease Models, Animal; Endothelium, Vascular; Eptifibatide; Hirudin Therapy; Male; Mice; Mice, Inbred C57BL; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stress, Mechanical; Thrombosis; Ticlopidine | 2016 |
A rabbit model of cerebral microembolic signals for translational research: preclinical validation for aspirin and clopidogrel.
Topics: Animals; Aspirin; Carotid Artery Thrombosis; Chlorides; Clopidogrel; Disease Models, Animal; Drug Evaluation, Preclinical; Ferric Compounds; Fibrinolytic Agents; Intracranial Embolism; Male; Middle Cerebral Artery; Platelet Aggregation; Rabbits; Stroke; Ticlopidine; Translational Research, Biomedical; Ultrasonography; Ultrasonography, Doppler | 2016 |
Aspirin and Clopidogrel Inhibit Aneurysm Healing after HydroCoil Implantation in External Carotid Artery Aneurysm Model.
Topics: Aneurysm; Animals; Aspirin; Carotid Artery Diseases; Carotid Artery, External; Cell Movement; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Embolization, Therapeutic; Equipment Design; Macrophages; Male; Platelet Aggregation Inhibitors; Platinum; Rats, Sprague-Dawley; Ticlopidine; Time Factors; Wound Healing | 2016 |
Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis.
Topics: Animals; Arteries; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Mice; Mice, Inbred C57BL; Platelet Aggregation; Pyridines; Rabbits; Thrombosis; Ticlopidine | 2016 |
Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps.
Topics: Animals; Blood Platelets; Cell Line; Clopidogrel; Disease Models, Animal; DNA; Epithelial Cells; Extracellular Traps; Humans; Kidney Tubular Necrosis, Acute; Kidney Tubules; Male; Mice, Inbred C57BL; Nephritis; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Factor 4; Reperfusion Injury; Signal Transduction; Ticlopidine; Time Factors | 2017 |
Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model.
Topics: Animals; Aspirin; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Graft Survival; Heparin; Hirudins; Ischemia; Laser-Doppler Flowmetry; Male; Microcirculation; Pentoxifylline; Postoperative Complications; Rats; Rats, Wistar; Skin Diseases; Skin Transplantation; Surgical Flaps; Ticlopidine | 2016 |
Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression.
Topics: Adenosine; Animals; Blood Coagulation; Blood Platelets; Carotid Artery Injuries; Cells, Cultured; Clopidogrel; Disease Models, Animal; Down-Regulation; Endothelial Cells; Equilibrative Nucleoside Transporter 1; Fibrinolytic Agents; Humans; Male; Mice, Inbred C57BL; Platelet Aggregation Inhibitors; Proteasome Endopeptidase Complex; Proteolysis; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thromboplastin; Thrombosis; Ticagrelor; Ticlopidine; Time Factors; Tumor Necrosis Factor-alpha | 2017 |
Improved Pig Model to Evaluate Heart Valve Thrombosis.
Topics: Animals; Aspirin; Blood Coagulation; Blood Platelets; Clopidogrel; Disease Models, Animal; Heart Valve Diseases; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Swine; Thrombosis; Ticlopidine | 2016 |
Short- and long-term efficacy of aspirin and clopidogrel for thromboprophylaxis for mechanical heart valves: an in vivo study in swine.
Topics: Administration, Oral; Animals; Aspirin; Bioprosthesis; Clopidogrel; Dalteparin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart Valve Prosthesis Implantation; Injections, Subcutaneous; Postoperative Care; Postoperative Complications; Random Allocation; Risk Factors; Sensitivity and Specificity; Statistics, Nonparametric; Survival Rate; Swine; Thromboembolism; Thrombolytic Therapy; Ticlopidine; Time Factors | 2008 |
Antithrombotic effect of clopidogrel in a vena cava thrombosis model in obese mice.
Topics: Animals; Clopidogrel; Dietary Fats; Disease Models, Animal; Fibrinolytic Agents; Mice; Mice, Obese; Ticlopidine; Venae Cavae; Venous Thrombosis | 2009 |
Association between the efficacy of dual antiplatelet therapy and the development of in-stent neointimal hyperplasia in porcine coronary arteries.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Animals; Aspirin; Cell Proliferation; Clopidogrel; Collagen; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Fibrin; Hyperplasia; Inflammation Mediators; Metals; P-Selectin; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prosthesis Design; Stents; Swine; Ticlopidine; Time Factors; Tunica Intima | 2008 |
Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Binding, Competitive; Bleeding Time; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hemorrhage; Hemostasis; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rabbits; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Thiophenes; Thrombosis; Ticlopidine | 2009 |
Long-term clopidogrel administration following severe coronary injury reduces proliferation and inflammation via inhibition of nuclear factor-kappaB and activator protein 1 activation in pigs.
Topics: Animals; Aspirin; Clopidogrel; Coronary Restenosis; Disease Models, Animal; Drug Therapy, Combination; NF-kappa B; Platelet Aggregation Inhibitors; Statistics as Topic; Sus scrofa; Ticlopidine; Time Factors; Transcription Factor AP-1 | 2009 |
Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cell Proliferation; Cells, Cultured; Clopidogrel; Disease Models, Animal; Endothelium, Vascular; Female; Fibrosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Aggregation Inhibitors; Sinus of Valsalva; Spleen; Stem Cells; T-Lymphocytes, Regulatory; Ticlopidine | 2009 |
Comparison of ticagrelor and thienopyridine P2Y(12) binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasis.
Topics: Adenosine; Animals; CHO Cells; Clopidogrel; Cricetinae; Cricetulus; Disease Models, Animal; Dogs; Hemostasis; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine; Transfection | 2009 |
Reduced intimal hyperplasia in rabbits via medical therapy after carotid venous bypass.
Topics: Administration, Oral; Animals; Atorvastatin; Benzopyrans; Calcium Dobesilate; Cardiovascular Agents; Carotid Stenosis; Clopidogrel; Disease Models, Animal; Ethanolamines; Graft Occlusion, Vascular; Heptanoic Acids; Hyperplasia; Jugular Veins; Male; Nebivolol; Pyrroles; Rabbits; Ticlopidine; Tunica Intima; Vascular Surgical Procedures | 2009 |
Antiplatelet therapy with clopidogrel or ticlopidine reduces intimal hyperplasia in an animal model of experimental arterial injury.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Animals; Arteries; Cell Division; Clopidogrel; Coronary Artery Bypass; Disease Models, Animal; Humans; Muscle, Smooth, Vascular; Myocardial Infarction; Platelet Aggregation Inhibitors; Rabbits; Ticlopidine | 2010 |
Combination of clopidogrel and everolimus dramatically reduced the development of transplant arteriosclerosis in murine aortic allografts.
Topics: Animals; Aorta, Abdominal; Arteriosclerosis; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Everolimus; Graft Rejection; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Platelet Aggregation; Platelet Aggregation Inhibitors; Sirolimus; Ticlopidine; Transplantation, Homologous; Treatment Outcome | 2010 |
Pharmacodynamic and pharmacokinetic evaluation of clopidogrel and the carboxylic acid metabolite SR 26334 in healthy dogs.
Topics: Adenosine Diphosphate; Animals; Blood Coagulation; Blood Platelets; Carboxylic Acids; Clopidogrel; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Ticlopidine | 2010 |
Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel.
Topics: Animals; Aspirin; Carotid Arteries; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Factor VIIa; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Regional Blood Flow; Thrombosis; Ticlopidine | 2010 |
Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model.
Topics: Adenosine; Animals; Bleeding Time; Blood Coagulation; Clopidogrel; Coronary Circulation; Coronary Thrombosis; Disease Models, Animal; Dogs; Drug Therapy, Combination; Echocardiography; Female; Fibrinolytic Agents; Laser-Doppler Flowmetry; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Thrombolytic Therapy; Ticagrelor; Ticlopidine; Time Factors; Tissue Plasminogen Activator | 2010 |
Platelet CD154 potentiates interferon-alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus.
Topics: Animals; Autoantibodies; Blood Platelets; CD40 Ligand; Clopidogrel; Dendritic Cells; Disease Models, Animal; Humans; Interferon-alpha; Lupus Erythematosus, Systemic; Mice; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Receptors, IgG; Ticlopidine | 2010 |
An endovascular canine middle cerebral artery occlusion model for the study of leptomeningeal collateral recruitment.
Topics: Angiography; Animals; Anticoagulants; Brain Ischemia; Carotid Arteries; Clopidogrel; Disease Models, Animal; Dogs; Feasibility Studies; Heparin; Infarction, Middle Cerebral Artery; Middle Cerebral Artery; Multivariate Analysis; Platelet Aggregation Inhibitors; Statistics as Topic; Ticlopidine | 2011 |
Role of intramural platelet thrombus in the pathogenesis of wall rupture and intra-ventricular thrombosis following acute myocardial infarction.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; Disease Models, Animal; Hemodynamics; Inflammation; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Myocardial Infarction; Platelet Aggregation Inhibitors; Telemetry; Thrombosis; Ticlopidine; Time Factors; Ventricular Septal Rupture | 2011 |
Humanized mouse model of thrombosis is predictive of the clinical efficacy of antiplatelet agents.
Topics: Animals; Biomarkers; Cell Adhesion; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Humans; Mice; Mice, 129 Strain; Mice, Mutant Strains; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Transfusion; Predictive Value of Tests; Receptors, Purinergic P2Y12; Species Specificity; Thrombosis; Ticlopidine; Transplantation, Heterologous; von Willebrand Factor | 2011 |
Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury.
Topics: Animals; Apolipoproteins E; Blood Platelets; Carotid Arteries; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; High-Energy Shock Waves; Humans; Immunohistochemistry; Mice; Mice, Knockout; Plaque, Atherosclerotic; Platelet Activation; Ticlopidine | 2011 |
Clopidogrel protects from cell apoptosis and oxidative damage in a mouse model of renal ischaemia-reperfusion injury.
Topics: Animals; Apoptosis; Clopidogrel; Disease Models, Animal; Fluorescent Antibody Technique; Immunoblotting; In Situ Nick-End Labeling; Kidney; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; Purinergic P2Y Receptor Antagonists; Reperfusion Injury; Ticlopidine | 2011 |
Beneficial effect of anti-platelet therapies on atherosclerotic lesion formation assessed by phase-contrast X-ray CT imaging.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Body Weight; Brachiocephalic Trunk; Cell Adhesion Molecules; Cholesterol, Dietary; Cilostazol; Clopidogrel; Collagen; Cytokines; Disease Models, Animal; Gene Expression Regulation; Immunohistochemistry; Inflammation Mediators; Lipids; Macrophages; Mice; Mice, Knockout; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles; Ticlopidine; Tomography, X-Ray Computed | 2012 |
Acetylsalicylic acid, but not clopidogrel, inhibits therapeutically induced cerebral arteriogenesis in the hypoperfused rat brain.
Topics: Animals; Aspirin; Brain Ischemia; Cell Line; Cerebral Angiography; Cerebrovascular Circulation; Chemotaxis, Leukocyte; Clopidogrel; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Male; Monocytes; Neovascularization, Physiologic; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Ticlopidine; Vasodilation | 2012 |
Anti-inflammatory and anti-thrombotic intervention strategies using atorvastatin, clopidogrel and knock-down of CD40L do not modify radiation-induced atherosclerosis in ApoE null mice.
Topics: Animals; Anti-Inflammatory Agents; Apolipoproteins E; Atherosclerosis; Atorvastatin; Carotid Arteries; CD40 Antigens; Clopidogrel; Disease Models, Animal; Heptanoic Acids; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Aggregation Inhibitors; Pyrroles; Radiation Dosage; Radiation Injuries, Experimental; Random Allocation; Reference Values; Statistics, Nonparametric; Ticlopidine | 2011 |
Clopidogrel, a P2Y12 receptor antagonist, potentiates the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritis.
Topics: Animals; Arthritis, Experimental; Clopidogrel; Cytokines; Disease Models, Animal; Drug Synergism; Female; Inflammation; Leukocytosis; Neutrophils; Peptidoglycan; Platelet Aggregation; Purinergic P2Y Receptor Antagonists; Rats; Receptors, Purinergic P2Y12; Thrombocytosis; Ticlopidine | 2011 |
Gene therapy with iNOS enhances regional contractility and reduces delayed contrast enhancement in a model of postischemic congestive heart failure.
Topics: Animals; Anticoagulants; Aspirin; Clopidogrel; Contrast Media; Coronary Angiography; Coronary Stenosis; Disease Models, Animal; Drug Carriers; Female; Fibrosis; Gadolinium; Genes, Reporter; Genes, Synthetic; Genetic Therapy; Heart Failure; Liposomes; Magnetic Resonance Imaging; Male; Myocardial Contraction; Myocardial Ischemia; Nitric Oxide Synthase Type II; Random Allocation; Stents; Sus scrofa; Swine; Ticlopidine; Ventricular Dysfunction, Left | 2011 |
Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice.
Topics: Animals; Aspirin; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Hemostasis; Mice; Mice, Knockout; Platelet Activation; Platelet Aggregation Inhibitors; Receptors, Proteinase-Activated; Thrombosis; Ticlopidine | 2012 |
Hepatocellular carcinoma: could antiplatelet drugs be used to prevent HBV-associated hepatocellular carcinoma?
Topics: Animals; Carcinoma, Hepatocellular; Chemoprevention; Clopidogrel; Disease Models, Animal; Disease Progression; Hepatitis B, Chronic; Humans; Liver Neoplasms; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Collagen-induced thrombosis in murine arteries and veins.
Topics: Animals; Arterial Occlusive Diseases; Blood Coagulation; Blood Platelets; Carotid Arteries; Clopidogrel; Collagen; Disease Models, Animal; Epigastric Arteries; Femoral Vein; Fibrin; Mice; Mice, Inbred C57BL; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Time Factors; Venous Thrombosis | 2013 |
Reversal of thienopyridine-induced platelet dysfunction following desmopressin administration.
Topics: Animals; Antidiuretic Agents; Bleeding Time; Clopidogrel; Deamino Arginine Vasopressin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Overdose; Hemostatics; Injections, Intravenous; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Purinergic P2Y Receptor Antagonists; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Ticlopidine | 2013 |
The impact of triple anti-platelet therapy for endothelialization and inflammatory response at overlapping bioabsorbable polymer coated drug-eluting stents in a porcine coronary model.
Topics: Absorbable Implants; Animals; Aspirin; Cilostazol; Clopidogrel; Coated Materials, Biocompatible; Coronary Restenosis; Coronary Vessels; Disease Models, Animal; Drug Therapy, Combination; Drug-Eluting Stents; Female; Inflammation; Neointima; Platelet Aggregation Inhibitors; Polymers; Swine; Tetrazoles; Ticlopidine; Treatment Outcome | 2013 |
Acute pulmonary embolism: don't ignore the platelet.
Topics: Acute Disease; Animals; Anticoagulants; Aspirin; Blood Platelets; Clinical Trials as Topic; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pulmonary Embolism; Secondary Prevention; Ticlopidine | 2002 |
Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist.
Topics: Adenosine Diphosphate; Animals; Clopidogrel; Disease Models, Animal; Drug Interactions; Mesenteric Arteries; Mice; Mice, Mutant Strains; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thromboplastin; Thrombosis; Ticlopidine; Vena Cava, Inferior | 2003 |
Platelet ADP receptors contribute to the initiation of intravascular coagulation.
Topics: Adult; Animals; Blood Coagulation; Blood Platelets; Clopidogrel; Collagen; Disease Models, Animal; Disseminated Intravascular Coagulation; Factor Xa; Humans; Leukocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Immunoelectron; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Reference Values; Thrombin; Thromboplastin; Thrombosis; Ticlopidine | 2004 |
An optimized murine model of ferric chloride-induced arterial thrombosis for thrombosis research.
Topics: Animals; Arterial Occlusive Diseases; Carotid Artery Diseases; Chlorides; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Ferric Compounds; Heparin; Kinetics; Mice; Regional Blood Flow; Research; Thrombosis; Ticlopidine | 2005 |
Protective effects of clopidogrel on oxidant damage in a rat model of acute ischemia.
Topics: Animals; Clopidogrel; Disease Models, Animal; Glutathione; Ischemia; Male; Malondialdehyde; Oxidants; Oxidative Stress; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Ticlopidine | 2005 |
Nitroaspirin plus clopidogrel versus aspirin plus clopidogrel against platelet thromboembolism and intimal thickening in mice.
Topics: Animals; Aspirin; Blood Coagulation Tests; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Hemorrhage; Male; Mice; Mice, Inbred Strains; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Survival Rate; Thromboembolism; Ticlopidine; Tunica Intima | 2005 |
Effect of clopidogrel on the expression of inflammatory markers in rabbit ischemic coronary artery.
Topics: Animals; Anti-Inflammatory Agents; CD40 Ligand; Clopidogrel; Coronary Vessels; Disease Models, Animal; Male; Myocardial Ischemia; P-Selectin; Platelet Aggregation Inhibitors; Rabbits; Thromboplastin; Ticlopidine | 2005 |
The antithrombotic effect of melagatran in combination with clopidogrel and/or aspirin (carotid artery primary thrombosis study).
Topics: Animals; Aspirin; Azetidines; Benzylamines; Bleeding Time; Blood Flow Velocity; Blood Pressure; Carotid Artery Thrombosis; Carotid Artery, Common; Clopidogrel; Disease Models, Animal; Dogs; Drug Therapy, Combination; Female; Fibrinolytic Agents; Heart Rate; Male; Partial Thromboplastin Time; Platelet Aggregation; Platelet Aggregation Inhibitors; Random Allocation; Ticlopidine; Tongue; Vascular Patency | 2005 |
Aspirin, but not clopidogrel, reduces collateral conductance in a rabbit model of femoral artery occlusion.
Topics: Animals; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Disease Models, Animal; Electrophysiology; Femoral Artery; Rabbits; Ticlopidine | 2005 |
Prevention of carotid artery restenosis after sirolimus-coated stent implantation in pigs.
Topics: Alloys; Angioplasty, Balloon, Coronary; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Carotid Arteries; Clopidogrel; Coronary Angiography; Coronary Restenosis; Disease Models, Animal; Male; Polymers; Sirolimus; Stents; Swine; Ticlopidine; Time Factors; Ultrasonics | 2006 |
Potent low dose platelet inhibitory effects of clopidogrel and aspirin on coronary thrombus formation in an animal model of acute unstable angina.
Topics: Acute Disease; Angina, Unstable; Animals; Aspirin; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; Drug Therapy, Combination; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Swine; Ticlopidine | 2006 |
[The effect of paclitaxel-eluting stents on restenosis].
Topics: Animals; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Restenosis; Coronary Vessels; Disease Models, Animal; Humans; Paclitaxel; Platelet Aggregation Inhibitors; Random Allocation; Secondary Prevention; Stents; Swine; Ticlopidine; Tunica Intima; Ultrasonography, Interventional | 2006 |
Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis.
Topics: Animals; Bleeding Time; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Eptifibatide; Fibrinolytic Agents; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Recombinant Fusion Proteins; Ticlopidine; Time Factors; Vascular Patency; von Willebrand Factor | 2006 |
Clopidogrel reduces the development of transplant arteriosclerosis.
Topics: Animals; Aorta; Arteriosclerosis; Clopidogrel; Disease Models, Animal; Graft Rejection; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Platelet Aggregation Inhibitors; Ticlopidine; Transplantation, Homologous | 2006 |
Effect of clopidogrel on nitric oxide levels in an ischemia reperfusion model.
Topics: Animals; Clopidogrel; Disease Models, Animal; Intubation, Gastrointestinal; Liver; Lung; Muscle, Skeletal; Nitric Oxide; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ticlopidine | 2006 |
Effect of clopidogrel on the inflammatory progression of early atherosclerosis in rabbits model.
Topics: Animals; Aspirin; Atherosclerosis; Atorvastatin; Chemokine CCL2; Clopidogrel; Diet, Atherogenic; Disease Models, Animal; Femoral Artery; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Intercellular Adhesion Molecule-1; Male; P-Selectin; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Ticlopidine; Vascular Cell Adhesion Molecule-1 | 2007 |
Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits.
Topics: Animals; Aspirin; Blood Coagulation; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Factor Xa; Fibrinolytic Agents; Hemorrhage; Hemostasis; Isoxazoles; Male; Platelet Aggregation; Pyrazoles; Rabbits; Thrombosis; Ticlopidine | 2007 |
Protein disulphide isomerase-mediated LA419- NO release provides additional antithrombotic effects to the blockade of the ADP receptor.
Topics: Administration, Oral; Animals; Blood Coagulation; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Female; Fibrinolytic Agents; Isosorbide Dinitrate; Nitric Oxide; Nitric Oxide Donors; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Disulfide-Isomerases; Proteomics; Purinergic P2 Receptor Antagonists; Random Allocation; Receptors, Purinergic P2; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Thrombosis; Ticlopidine; Vasodilator Agents | 2007 |
A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models.
Topics: Animals; Arteriovenous Shunt, Surgical; Carotid Artery Injuries; Clopidogrel; Disease Models, Animal; Dogs; In Vitro Techniques; Male; Membrane Proteins; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine | 2007 |
Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits.
Topics: Adenosine Diphosphate; Analysis of Variance; Animals; Aspirin; Biomarkers; Bleeding Time; Blood Platelets; Carotid Artery Thrombosis; Carotid Artery, Common; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Hemostasis; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Protein Binding; Rabbits; Receptors, Purinergic P2; Regional Blood Flow; Thromboxane B2; Ticlopidine | 2007 |
A thromboxane A2/prostaglandin H2 receptor antagonist (S18886) shows high antithrombotic efficacy in an experimental model of stent-induced thrombosis.
Topics: Administration, Oral; Animals; Aorta; Aspirin; Bleeding Time; Blood Coagulation; Clopidogrel; Disease Models, Animal; Fibrin; Fibrinogen; Fibrinolytic Agents; Hemorrhage; Naphthalenes; Platelet Activation; Platelet Aggregation Inhibitors; Propionates; Prosthesis Design; Receptors, Thromboxane A2, Prostaglandin H2; Stainless Steel; Stents; Swine; Thrombosis; Ticlopidine; Time Factors | 2007 |
Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension.
Topics: Actins; Adenosine Triphosphate; Angiotensin II; Animals; Arterioles; Blood Pressure; Cell Proliferation; Clopidogrel; Disease Models, Animal; Hypertension; Hypertrophy; Kidney; Male; Membrane Proteins; Mesangial Cells; Purinergic Antagonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Receptors, Purinergic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Renin; Ticlopidine | 2008 |
Coronary artery in-stent stenosis persists despite inhibition of the von Willebrand factor--collagen interaction in baboons.
Topics: Angioplasty, Balloon, Coronary; Animals; Antibodies, Monoclonal; Aspirin; Clopidogrel; Collagen; Coronary Stenosis; Coronary Vessels; Disease Models, Animal; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Male; Papio ursinus; Platelet Adhesiveness; Stents; Ticlopidine; Time Factors; Tunica Intima; von Willebrand Factor | 2007 |
Iliac venous stenting: antithrombotic efficacy of PD0348292, an oral direct Factor Xa inhibitor, compared with antiplatelet agents in pigs.
Topics: Administration, Oral; Angioplasty; Animals; Antithrombin III; Aspirin; Clopidogrel; Constriction, Pathologic; Disease Models, Animal; Drug Therapy, Combination; Female; Iliac Vein; Preoperative Care; Probability; Pyridones; Pyrrolidines; Random Allocation; Reference Values; Stents; Ticlopidine; Treatment Outcome; Vascular Patency; Venous Thrombosis | 2008 |
Effect of chronic treatment with acetylsalicylic acid and clopidogrel on atheroprogression and atherothrombosis in ApoE-deficient mice in vivo.
Topics: Animals; Aorta; Apolipoproteins E; Aspirin; Atherosclerosis; Blood Platelets; Carotid Arteries; Cholesterol, Dietary; Clopidogrel; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Endothelial Cells; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Microscopy, Video; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Rupture; Thrombosis; Ticlopidine; Time Factors | 2008 |
Comparison of PD0348292, a selective factor Xa inhibitor, to antiplatelet agents for the inhibition of arterial thrombosis.
Topics: Administration, Oral; Animals; Aspirin; Bleeding Time; Blood Coagulation; Carotid Artery Injuries; Carotid Artery Thrombosis; Clopidogrel; Disease Models, Animal; Factor Xa Inhibitors; Female; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridones; Pyrrolidines; Sus scrofa; Thrombosis; Ticlopidine | 2008 |
An experimental myocardial infarction model in the rat and its properties.
Topics: Animals; Biphenyl Compounds; Clopidogrel; Coronary Vessels; Disease Models, Animal; Electrocardiography; Heptanoic Acids; Ketanserin; Male; Myocardial Infarction; Oxygen; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombosis; Ticlopidine | 1995 |
Clopidogrel is more effective than aspirin in preventing coronary artery reocclusion after thrombolysis.
Topics: Animals; Aspirin; Blood Coagulation; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; Dogs; Drug Therapy, Combination; Hematocrit; Heparin; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Thrombolytic Therapy; Ticlopidine; Tissue Plasminogen Activator | 1993 |
Experimental thrombosis on a collagen coated arterioarterial shunt in rats: a pharmacological model to study antithrombotic agents inhibiting thrombin formation and platelet deposition.
Topics: Animals; Anticoagulants; Arterio-Arterial Fistula; Aspirin; Carotid Artery Thrombosis; Clopidogrel; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Fibrin; Fibrinogen; Fibrinolytic Agents; Glass; Heparin; Hirudin Therapy; Hirudins; Male; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Polyethylenes; Rats; Rats, Wistar; Recombinant Proteins; Regional Blood Flow; Silicones; Thrombin; Ticlopidine | 1993 |
Effects of clopidogrel, aspirin and combined therapy in a porcine ex vivo model of high-shear induced stent thrombosis.
Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Bleeding Time; Blood Platelets; Clopidogrel; Coronary Vessels; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Occlusion, Vascular; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Swine; Ticlopidine | 1998 |
Comparison of the antithrombotic effects of heparin, hirudin and clopidogrel according to the nature of the thrombogenic surface in an arterioarterial shunt in rats.
Topics: Animals; Clopidogrel; Disease Models, Animal; Female; Fibrinolytic Agents; Heparin; Hirudins; Rats; Rats, Wistar; Thrombosis; Ticlopidine | 1999 |
The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arteriovenous Shunt, Surgical; Binding, Competitive; Bleeding Time; Blood Platelets; Clopidogrel; Collagen; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Thiophenes; Thrombin; Thrombosis; Ticlopidine; Time Factors; Tritium | 2000 |
Thrombostatin inhibits cyclic flow variations in stenosed canine coronary arteries.
Topics: Animals; Aspirin; Blood Coagulation Tests; Bradykinin; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Disease Models, Animal; Dogs; Drug Evaluation; Metabolic Clearance Rate; Peptide Fragments; Platelet Function Tests; Regional Blood Flow; Therapeutic Equivalency; Ticlopidine; Time Factors | 2001 |
Anti-angiogenic effects of the thienopyridine SR 25989 in vitro and in vivo in a murine pulmonary metastasis model.
Topics: Angiogenesis Inhibitors; Animals; Aorta; Cell Division; Clopidogrel; Disease Models, Animal; Foot; Gene Expression Regulation; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred C57BL; Microcirculation; Neoplasm Metastasis; Neoplasms, Experimental; Neovascularization, Pathologic; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Skin Neoplasms; Thrombospondin 1; Ticlopidine; Tumor Cells, Cultured | 2002 |
Importance of platelets in experimental venous thrombosis in the rat.
Topics: Animals; Blood Platelets; Clopidogrel; Disease Models, Animal; Heparin; Hirudins; Leukopenia; Male; Mechlorethamine; Partial Thromboplastin Time; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Thrombocytopenia; Thrombophlebitis; Thromboplastin; Ticlopidine | 1992 |
Comparative arterial antithrombotic activity of clopidogrel and acetyl salicylic acid in the pig.
Topics: Animals; Aspirin; Bleeding Time; Clopidogrel; Disease Models, Animal; Female; Femoral Artery; Fibrinolytic Agents; Male; Platelet Aggregation; Swine; Thrombosis; Ticlopidine | 1992 |
[Antiplatelet effect of clopidogrel].
Topics: Adenosine Diphosphate; Adolescent; Adult; Animals; Bleeding Time; Clopidogrel; Disease Models, Animal; Dogs; Drug Evaluation; Female; Humans; Intracranial Embolism and Thrombosis; Male; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Rabbits; Rats; Thrombosis; Ticlopidine | 1992 |
[Arterioarterial shunt coated with collagen. A model of acute arterial thrombosis for testing antithrombotic agents in rats].
Topics: Animals; Aspirin; Carotid Arteries; Clopidogrel; Collagen; Disease Models, Animal; Fistula; Graft Occlusion, Vascular; Male; Models, Biological; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thrombolytic Therapy; Thrombosis; Ticlopidine | 1991 |
ADP plays a key role in thrombogenesis in rats.
Topics: Adenosine Diphosphate; Animals; Clopidogrel; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; In Vitro Techniques; Ketanserin; Platelet Aggregation; Rats; Rats, Inbred Strains; Serotonin; Thrombosis; Ticlopidine | 1988 |