clopenthixol-acetate-ester and Perceptual-Disorders

In this study we report the results of two experiments on visual attention conducted with patients with early-onset schizophrenia. These experiments investigated the effect of irrelevant spatial-scale information upon the processing of relevant spatial-scale information, and the ability to shift the spatial scale of attention, across consecutive trials, between different levels of the hierarchical stimulus. Twelve patients with early-onset schizophrenia and matched controls performed local-global tasks under: (1) directed attention conditions with a consistency manipulation and (2) divided-attention conditions. In the directed-attention paradigm, the early-onset patients exhibited the normal patterns of global advantage and interference, and were not unduly affected by the consistency manipulation. Under divided-attention conditions, however, the early-onset patients exhibited a local-processing deficit. The source of this local processing deficit lay in the prolonged reaction time to local targets, when these had been preceded by a global target, but not when preceded by a local target. These findings suggest an impaired ability to shift the spatial scale of attention from a global to a local spatial scale in early-onset schizophrenia.

Topics: Adolescent; Affect; Antipsychotic Agents; Attention; Benzodiazepines; Clopenthixol; Diazepam; Female; Flupenthixol; Frontal Lobe; Humans; Male; Olanzapine; Parietal Lobe; Perceptual Disorders; Pirenzepine; Reaction Time; Risperidone; Schizophrenia; Space Perception; Time Factors