clopenthixol-acetate-ester and Parkinson-Disease--Secondary

clopenthixol-acetate-ester has been researched along with Parkinson-Disease--Secondary* in 1 studies

Other Studies

1 other study(ies) available for clopenthixol-acetate-ester and Parkinson-Disease--Secondary

ArticleYear
Clinical and pharmacokinetic evaluation of zuclopenthixol acetate in Viscoleo.
    Pharmacopsychiatry, 1989, Volume: 22, Issue:6

    The purpose of the present study was to evaluate zuclopenthixol acetate in Viscoleo, a new preparation to be administered once every 3 days, in the early treatment of acute psychotic episodes and acute deterioration of chronic psychosis. 21 cases were included in the study: patients received 1 to 3 injections. Clinical evaluation was made at 24, 48 and 72 hours after each injection, using the Clinical Global Impressions (CGI) and the Brief Psychiatric Rating Scale (BPRS). Results at end-point indicated a marked or moderate therapeutic effect in the 11 cases of acute psychosis. A statistically significant decrease was observed for the total BPRS score as well as for its subscales. Among 8 cases of exacerbation of chronic psychosis, 4 patients showed a moderate therapeutic effect, and minimal or no effect was found in the other 4 subjects. The total BPRS decreased significantly, but to a lesser extent than for acute psychosis. Two patients suffering from mania showed a moderate therapeutic effect according to CGI. 8 cases of acute psychosis and 5 cases of chronic psychosis did not suffer from any neurological side-effects. Plasma concentration measurements suggest that a dose of 50 mg per 3 days may be sufficient for early treatment of most acutely ill psychotic patients.

    Topics: Adolescent; Adult; Antipsychotic Agents; Bipolar Disorder; Clopenthixol; Female; Humans; Male; Middle Aged; Parkinson Disease, Secondary; Psychiatric Status Rating Scales; Psychotic Disorders; Thioxanthenes

1989