clopenthixol-acetate-ester has been researched along with Catatonia* in 2 studies
1 trial(s) available for clopenthixol-acetate-ester and Catatonia
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Zuclopenthixol-acetate treatment in catatonic patients: the implication of iron metabolism.
There is some evidence of ferropenia correlating with neuroleptic malignant syndrome and catatonic symptoms. The aim of this prospective and naturalistic study was to investigate the implications of ferremia in patients undergoing an intramuscular injection treatment of Zuclopenthixol-acetate in Visceolo. We recruited 59 catatonic patients (33 females). Age, sex, psychiatric and somatic diagnoses, body mass index (BMI), dosage and duration of Zuclopenthixol-acetate medication and the timing of the changeover from intramuscular to oral prescription, the single dosage of Clopenthixol if initially coadministered, incidence, onset and duration of transient benign hyperthermia, iron, ferritin, transferrin and saturation values, and white and red blood cell counts as well as liver function and electrolytes were registered. A transient and benign hyperthermic reaction (mean degrees: 37.5 + 0.3 degrees C) lasting for an average of 3.0 + 1.9 d was shown by 72.9% patients (N = 43, 22 females), during a mean treatment period of 5.8 + 3.1 d. These patients were medicated with significant different mean doses of Zuclopenthixol-acetate and compared to the patients with normal body temperature (ANOVA P < 0.01). The duration of Zuclopenthixol-acetate application did not vary between these patients groups. Furthermore, significant differences of iron (59.5 + 30.6 micromol/dl vs. 87.8 + 40.8 micromol/dl; ANOVA P < 0.006) and transferrin saturation values (18.3 + 10.4% vs. 27.2 + 17.0%; ANOVA P < 0.02) were found. Ferritin and transferrin were not implicated in the episode of hyperthermia. Diagnoses, sex, white and red blood cell counts also did not vary between these groups. Our findings indicate a possible involvement of ferropenia in catatonic patients, regardless of the diagnoses, and in the development of benign transient hyperthermia, also known as drug fever. Topics: Administration, Oral; Adult; Antipsychotic Agents; Catatonia; Clopenthixol; Female; Humans; Injections, Intramuscular; Iron; Male; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2003 |
1 other study(ies) available for clopenthixol-acetate-ester and Catatonia
Article | Year |
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Recurrent sinus arrest in association with neuroleptic malignant syndrome.
We report a case of neuroleptic malignant syndrome where the catatonia clearly followed the administration of neuroleptics and where the neurovegetative disturbance was remarkably severe, including episodes of tracheal spasm, apnoea and episodes of bradycardia, and sinus arrest requiring insertion of a temporary external pacing wire. To our knowledge, such severe disturbance has not previously been reported. Topics: Adult; Antipsychotic Agents; Cardiac Pacing, Artificial; Catatonia; Chlorpromazine; Clopenthixol; Drug Therapy, Combination; Electrocardiography; Female; Haloperidol; Heart Arrest; Humans; Neuroleptic Malignant Syndrome; Neurologic Examination; Schizophrenia | 1994 |