clonidine has been researched along with Trigeminal Neuralgia in 11 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Trigeminal Neuralgia: A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a double-blind study the efficacy and tolerability of tizanidine was compared with those of carbamazepine in the management of trigeminal neuralgia." | 9.06 | Tizanidine in the management of trigeminal neuralgia. ( Lataste, X; Lyberg, T; Vilming, ST, 1986) |
| "In the present study we report two typical cases of trigeminal neuralgia in whom all conventional drug treatments were attempted without success, and in whom low doses of pimozide, a dopaminergic blocking agent, provoked a definite and sustained improvement." | 7.67 | Definite and sustained improvement with pimozide of two patients with severe trigeminal neuralgia. Some neurochemical, neurophysiological and neuroendocrinological findings. ( Amat, J; Arocha, L; Cabrera, A; Gómez, F; Jiménez, V; Lechin, AE; Lechin, F; Lechin, ME; van der Dijs, B, 1988) |
| "The limited efficacy of TZD in the treatment of trigeminal neuralgia may be related to the fact that it has no effect on neuronal responses to low-threshold mechanoceptive stimuli, suggesting that low-threshold mechanoceptive neurons play an important role in the pathogenesis of trigeminal neuralgia." | 6.67 | A clinical and experimental investigation of the effects of tizanidine in trigeminal neuralgia. ( Aumentado, D; Fromm, GH; Terrence, CF, 1993) |
| "In a double-blind study the efficacy and tolerability of tizanidine was compared with those of carbamazepine in the management of trigeminal neuralgia." | 5.06 | Tizanidine in the management of trigeminal neuralgia. ( Lataste, X; Lyberg, T; Vilming, ST, 1986) |
| "There is low-quality evidence that the effect of tizanidine is not significantly different than that of carbamazepine in treating trigeminal neuralgia." | 4.89 | Non-antiepileptic drugs for trigeminal neuralgia. ( Chen, N; He, L; Yang, M; Zakrzewska, JM; Zhang, J; Zhou, M, 2013) |
| "In the present study we report two typical cases of trigeminal neuralgia in whom all conventional drug treatments were attempted without success, and in whom low doses of pimozide, a dopaminergic blocking agent, provoked a definite and sustained improvement." | 3.67 | Definite and sustained improvement with pimozide of two patients with severe trigeminal neuralgia. Some neurochemical, neurophysiological and neuroendocrinological findings. ( Amat, J; Arocha, L; Cabrera, A; Gómez, F; Jiménez, V; Lechin, AE; Lechin, F; Lechin, ME; van der Dijs, B, 1988) |
| "The limited efficacy of TZD in the treatment of trigeminal neuralgia may be related to the fact that it has no effect on neuronal responses to low-threshold mechanoceptive stimuli, suggesting that low-threshold mechanoceptive neurons play an important role in the pathogenesis of trigeminal neuralgia." | 2.67 | A clinical and experimental investigation of the effects of tizanidine in trigeminal neuralgia. ( Aumentado, D; Fromm, GH; Terrence, CF, 1993) |
| "Tizanidine was investigated in two trials." | 2.43 | Non-antiepileptic drugs for trigeminal neuralgia. ( He, L; Wu, B; Zhou, M, 2006) |
| "Among the more common symptoms is spasticity." | 2.41 | Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis. ( Schapiro, RT, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Jacques, N | 1 |
| Karoutsos, S | 1 |
| Marais, L | 1 |
| Nathan-Denizot, N | 1 |
| Escrivá, E | 1 |
| Martínez-Costa, L | 1 |
| Zhang, J | 1 |
| Yang, M | 2 |
| Zhou, M | 3 |
| He, L | 3 |
| Chen, N | 2 |
| Zakrzewska, JM | 2 |
| Takeda, M | 1 |
| Ikeda, M | 1 |
| Tanimoto, T | 1 |
| Lipski, J | 1 |
| Matsumoto, S | 1 |
| Naja, MZ | 1 |
| Al-Tannir, M | 1 |
| Naja, H | 1 |
| Ziade, MF | 1 |
| Zeidan, A | 1 |
| Wu, B | 1 |
| Fromm, GH | 1 |
| Aumentado, D | 1 |
| Terrence, CF | 1 |
| Schapiro, RT | 1 |
| Lechin, F | 1 |
| van der Dijs, B | 1 |
| Amat, J | 1 |
| Lechin, AE | 1 |
| Cabrera, A | 1 |
| Lechin, ME | 1 |
| Gómez, F | 1 |
| Arocha, L | 1 |
| Jiménez, V | 1 |
| Vilming, ST | 1 |
| Lyberg, T | 1 |
| Lataste, X | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Analgesic Effect Evaluation of Ultrasound Guided Maxillary Nerve Block in Trigeminal Neuralgia[NCT06129071] | 10 participants (Anticipated) | Interventional | 2023-12-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for clonidine and Trigeminal Neuralgia
| Article | Year |
|---|---|
Quality of life after trigeminal nerve block in refractory trigeminal neuralgia: A retrospective cohort study and literature review.
Topics: Clonidine; Humans; Levobupivacaine; Observational Studies as Topic; Quality of Life; Retrospective S | 2022 |
Non-antiepileptic drugs for trigeminal neuralgia.
Topics: Amitriptyline; Analgesics; Anticonvulsants; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans | 2013 |
Non-antiepileptic drugs for trigeminal neuralgia.
Topics: Amitriptyline; Analgesics; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans; Pimozide; Propo | 2011 |
Non-antiepileptic drugs for trigeminal neuralgia.
Topics: Amitriptyline; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans; Pimozide; Propoxycaine; Ran | 2006 |
Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis.
Topics: Acetates; Amines; Autoimmune Diseases; Baclofen; Benzodiazepines; Botulinum Toxins, Type A; Cannabin | 2001 |
2 trials available for clonidine and Trigeminal Neuralgia
| Article | Year |
|---|---|
A clinical and experimental investigation of the effects of tizanidine in trigeminal neuralgia.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Animals; Cats; Clonidine; Double-Blind Method; Drug Resi | 1993 |
Tizanidine in the management of trigeminal neuralgia.
Topics: Aged; Analgesics; Carbamazepine; Clinical Trials as Topic; Clonidine; Double-Blind Method; Humans; M | 1986 |
4 other studies available for clonidine and Trigeminal Neuralgia
| Article | Year |
|---|---|
[Incomplete Horner's syndrome as a presenting sign of fourth ventricle ependymoma].
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Blepharoptosis; Cerebral Ventricle Neoplasms; Clonidine | 2013 |
Changes of the excitability of rat trigeminal root ganglion neurons evoked by alpha(2)-adrenoreceptors.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Brimonidine Tartrate; Cell | 2002 |
Repeated nerve blocks with clonidine, fentanyl and bupivacaine for trigeminal neuralgia.
Topics: Anesthetics; Bupivacaine; Chronic Disease; Clonidine; Electric Stimulation; Fentanyl; Humans; Nerve | 2006 |
Definite and sustained improvement with pimozide of two patients with severe trigeminal neuralgia. Some neurochemical, neurophysiological and neuroendocrinological findings.
Topics: Aged; Clonidine; Colon; Depression; Female; Gastrointestinal Motility; Humans; Male; Middle Aged; No | 1988 |