clonidine has been researched along with Spinal Cord Injuries in 80 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed a double-blinded, randomized, controlled trial in 15 patients to determine the efficacy of intrathecal morphine or clonidine, alone or combined, in the treatment of neuropathic pain after spinal cord injury." | 9.09 | The efficacy of intrathecal morphine and clonidine in the treatment of pain after spinal cord injury. ( Cousins, MJ; Mather, LE; Molloy, AR; Rutkowski, SB; Siddall, PJ; Walker, S, 2000) |
| "Tizanidine hydrochloride, an alpha(2)-adrenergic receptor agonist, is a widely used medication for the treatment of muscle spasticity." | 8.84 | Update on tizanidine for muscle spasticity and emerging indications. ( Garay, E; Malanga, G; Reiter, RD, 2008) |
| "Tizanidine is an imidazoline central alpha(2)-adrenoceptor agonist widely used to manage spasticity secondary to conditions such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI)." | 8.84 | A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. ( Henney, HR; Kamen, L; Runyan, JD, 2008) |
| "To report a case of possible clonidine-induced hypertension (by Naranjo score) in a patient with a C4 spinal lesion." | 7.71 | Clonidine-induced hypertension in a patient with a spinal lesion. ( Backo, AL; Clause, SL; Gibbs, KA; Triller, DM, 2002) |
| " We describe a case of chronic pain following SCI which failed to respond to a variety of approaches including intrathecal administration of morphine." | 7.69 | Intrathecal morphine and clonidine in the management of spinal cord injury pain: a case report. ( Cousins, MJ; Gray, M; Rutkowski, S; Siddall, PJ, 1994) |
| "Clonidine was administered by epidural injections with per os relay and long term therapeutic follow-up to 38 patients with deafferentation neurological sequellar pain either fully or partly intractable to classical pain treatments." | 7.67 | [Thoracolumbar or sacral epidural administration of clonidine in deafferentation pain: possibilities, limits and long-term follow-up]. ( Farcot, JM; Grasser, C; Mercky, F, 1989) |
| "Once clonidine was discontinued, the resting heart rate returned to normal." | 5.29 | Clonidine-induced bradycardia in patients with spinal cord injury. ( Rosenblum, D, 1993) |
| "We performed a double-blinded, randomized, controlled trial in 15 patients to determine the efficacy of intrathecal morphine or clonidine, alone or combined, in the treatment of neuropathic pain after spinal cord injury." | 5.09 | The efficacy of intrathecal morphine and clonidine in the treatment of pain after spinal cord injury. ( Cousins, MJ; Mather, LE; Molloy, AR; Rutkowski, SB; Siddall, PJ; Walker, S, 2000) |
| "Tizanidine hydrochloride, an alpha(2)-adrenergic receptor agonist, is a widely used medication for the treatment of muscle spasticity." | 4.84 | Update on tizanidine for muscle spasticity and emerging indications. ( Garay, E; Malanga, G; Reiter, RD, 2008) |
| "Tizanidine is an imidazoline central alpha(2)-adrenoceptor agonist widely used to manage spasticity secondary to conditions such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI)." | 4.84 | A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. ( Henney, HR; Kamen, L; Runyan, JD, 2008) |
| "The objective of this brief review is to compare the effects of clonidine on walking capabilities in SCI subjects with functionally complete and incomplete spinal cord injuries." | 4.82 | The effect of noradrenergic drugs on the recovery of walking after spinal cord injury. ( Barbeau, H; Norman, KE, 2003) |
| "To report a case of possible clonidine-induced hypertension (by Naranjo score) in a patient with a C4 spinal lesion." | 3.71 | Clonidine-induced hypertension in a patient with a spinal lesion. ( Backo, AL; Clause, SL; Gibbs, KA; Triller, DM, 2002) |
| ") injection of clonidine (30, 60 and 90 microg) on the polysynaptic spinal reflexes (PSR) elicited by electrical stimulation of flexor reflex afferents (FRA), monosynaptic reflex and gait of 11 subjects with spinal cord injuries." | 3.70 | Effects of intrathecal clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects. ( Barbeau, H; Boiteau, F; Bussel, B; Daniel, O; Rémy-Néris, O, 1999) |
| " We describe a case of chronic pain following SCI which failed to respond to a variety of approaches including intrathecal administration of morphine." | 3.69 | Intrathecal morphine and clonidine in the management of spinal cord injury pain: a case report. ( Cousins, MJ; Gray, M; Rutkowski, S; Siddall, PJ, 1994) |
| "Ten patients with deafferentation pain after spinal cord injury were given 150 micrograms clonidine epidurally." | 3.68 | Cerebrospinal fluid kinetics of epidural clonidine in man. ( Glynn, CJ; Jamous, MA; Teddy, PJ, 1992) |
| "The efficiency and duration of action of a single oral dose (8 mg) of tizanidine in patients with spinal cord injuries were determined by studying its antispastic, cardiovascular and sedative effects along with its pharmacokinetic profile in five tetraplegic and five paraplegic patients." | 3.67 | Pharmacodynamics and pharmacokinetics of the oral antispastic agent tizanidine in patients with spinal cord injury. ( Baker, H; Desai, P; el Masri, W; Frankel, HL; Luckitt, J; Mathias, CJ, 1989) |
| "Clonidine was administered by epidural injections with per os relay and long term therapeutic follow-up to 38 patients with deafferentation neurological sequellar pain either fully or partly intractable to classical pain treatments." | 3.67 | [Thoracolumbar or sacral epidural administration of clonidine in deafferentation pain: possibilities, limits and long-term follow-up]. ( Farcot, JM; Grasser, C; Mercky, F, 1989) |
| "Baclofen was associated with minor changes in walking." | 2.69 | Effects of drugs on walking after spinal cord injury. ( Barbeau, H; Norman, KE; Pépin, A, 1998) |
| "In twenty-five SCI subjects, antispasticity effects of three putative antispasticity agents [clonidine (an alpha-2 noradrenergic agonist), cyproheptadine (a 5-HT2 antagonist) and baclofen (a GABA-B agonist)] were tested in terms of changes in leg tone as graded by the Ashworth scale (AS), in terms of the vibratory inhibition of the H-reflex (VII) and in terms of the ability of the knee to swing passively in the pendulum test as quantified by video motion analysis." | 2.67 | A comparison of clonidine, cyproheptadine and baclofen in spastic spinal cord injured patients. ( Nance, PW, 1994) |
| "Tizanidine was titrated to an optimized dosage in each patient to a maximum of 36 mg/d." | 2.67 | Efficacy and safety of tizanidine in the treatment of spasticity in patients with spinal cord injury. North American Tizanidine Study Group. ( Bugaresti, J; Martinez-Arizala, A; Nance, PW; Shellenberger, K; Sheremata, W, 1994) |
| "In ten of these 12 patients, other antispasticity drugs were either reduced or discontinued." | 2.67 | Clonidine transdermal system for treatment of spasticity in spinal cord injury. ( Belen, JG; Weingarden, SI, 1992) |
| "All 3 spastic paretic patients had kinematic deviations and abnormal EMG recruitment profiles during the premedication or placebo sessions." | 2.67 | Modulation of locomotor patterns and spasticity with clonidine in spinal cord injured patients. ( Barbeau, H; Gauthier, S; Stewart, JE, 1991) |
| "In conclusion, clonidine has an anti-spasticity effect in SCI patients, both subjectively, and objectively, in terms of vibratory inhibition of the H reflex." | 2.66 | Reflex changes induced by clonidine in spinal cord injured patients. ( Nance, DM; Nance, PW; Shears, AH, 1989) |
| "Intrathecal clonidine is a powerful antispastic drug." | 2.41 | Intrathecal clonidine for controlling spastic hypertonia. ( Bussel, B; Denys, P; Rémy-Néris, O, 2001) |
| "With the introduction of the antispasticity agent, tizanidine hydrochloride (Zanaflex), physicians have requested information about the optimal way to switch appropriate patients from baclofen to tizanidine." | 2.40 | An approach to switching patients from baclofen to tizanidine. ( Brenner, R; Hyman, N; Knobler, R; O'Brien, M; Stephan, T, 1998) |
| "Tizanidine (2mg) was administered (4\\day), for 4 weeks." | 1.42 | Comparison between the therapeutic effects of robotic-assisted locomotor training and an anti-spastic medication on spasticity. ( Mirbagheri, MM, 2015) |
| "Cervical incomplete spinal cord injuries often lead to severe and persistent impairments of sensorimotor functions and are clinically the most frequent type of spinal cord injury." | 1.37 | Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome. ( Filli, L; Schwab, ME; Weinmann, O; Zörner, B, 2011) |
| "Pre-treatment with clonidine (10 microg/animal) completely prevented the yohimbine-induced GMP, implying that its effect was exerted upon alpha(2)-adrenoceptors." | 1.32 | Yohimbine reverses the exhaustion of the coital reflex in spinal male rats. ( Carro-Juáreza, M; Rodríguez-Manzo, G, 2003) |
| "Such episodes (known as autonomic dysreflexia) are thought to result from the loss of descending baroreflex inhibition and/or plasticity within the spinal cord." | 1.32 | Tail arteries from chronically spinalized rats have potentiated responses to nerve stimulation in vitro. ( Brock, JA; McLachlan, EM; Yeoh, M, 2004) |
| "In most cases, drug-related spinal cord injuries have resulted from the compression of a spinal inflammatory mass or abcess rather than from a direct neurotoxic effect." | 1.32 | Spinal cord lesion after long-term intrathecal clonidine and bupivacaine treatment for the management of intractable pain. ( Buchser, E; Chédel, D; Hirt, L; Maeder, P; Perren, F; Vingerhoets, F, 2004) |
| " After an acute, 1-day spinalization, there was no change in the antinociceptive dose-response function to clonidine, relative to intact rats." | 1.31 | Spinal transection increases the potency of clonidine on the tail-flick and hindlimb flexion reflexes. ( Advokat, C, 2002) |
| "It provides effective reduction of spasticity without affecting muscle strength." | 1.30 | Spasticity: current and future management. Royal College of Physicians, November 13, 1997. ( , 1998) |
| "clonidine was reversed by the selective alpha 2-adrenoceptor antagonist atipamezole." | 1.29 | Effects of intrathecal vs. systemic clonidine in treating chronic allodynia-like response in spinally injured rats. ( Hao, JX; Wiesenfeld-Hallin, Z; Xu, XJ; Yu, W, 1996) |
| "Once clonidine was discontinued, the resting heart rate returned to normal." | 1.29 | Clonidine-induced bradycardia in patients with spinal cord injury. ( Rosenblum, D, 1993) |
| "Clonidine was added to baclofen in the pump reservoir and both drugs were administered intrathecally in combination." | 1.29 | Intrathecal clonidine and baclofen in the management of spasticity and neuropathic pain following spinal cord injury: a case study. ( Middleton, JW; Molloy, AR; Rutkowski, SB; Siddall, PJ; Walker, S, 1996) |
| "This led to successfully oral treatment of the orthostatic hypotension with clonidine 150 micrograms bd and midodrine 10 mg bd." | 1.28 | Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report. ( Arias, A; Berlan, M; Montastruc, JL; Rascol, A; Senard, JM; Tran, MA, 1991) |
| "Autonomic hyperreflexia occurs in spinal cord injured patients." | 1.27 | Autonomic hyperreflexia in spinal cord injured patients: trigger mechanism--dressing changes of pressure sores. ( Hall, PA; Young, JV, 1983) |
| "Clonidine was used as an adjunct to baclofen in 55 patients with spasticity due to spinal cord injury." | 1.27 | Clonidine effect on spasticity: a clinical trial. ( Carter, RE; Donovan, WH; Rossi, CD; Wilkerson, MA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (10.00) | 18.7374 |
| 1990's | 24 (30.00) | 18.2507 |
| 2000's | 33 (41.25) | 29.6817 |
| 2010's | 14 (17.50) | 24.3611 |
| 2020's | 1 (1.25) | 2.80 |
| Authors | Studies |
|---|---|
| Kwaśniewska, A | 1 |
| Miazga, K | 1 |
| Majczyński, H | 1 |
| Jordan, LM | 1 |
| Zawadzka, M | 1 |
| Sławińska, U | 1 |
| Mirbagheri, MM | 7 |
| Kindig, M | 1 |
| Niu, X | 2 |
| Varoqui, D | 1 |
| Chu, VW | 1 |
| Hornby, TG | 1 |
| Schmit, BD | 1 |
| Duffell, LD | 4 |
| Brown, GL | 3 |
| Brown, G | 1 |
| Lapointe, NP | 2 |
| Ung, RV | 2 |
| Rouleau, P | 2 |
| Guertin, PA | 2 |
| Malanga, G | 1 |
| Reiter, RD | 1 |
| Garay, E | 1 |
| Chen, D | 1 |
| Rymer, WZ | 1 |
| Rummery, NM | 1 |
| Tripovic, D | 1 |
| McLachlan, EM | 3 |
| Brock, JA | 4 |
| Rank, MM | 1 |
| Murray, KC | 1 |
| Stephens, MJ | 1 |
| D'Amico, J | 1 |
| Gorassini, MA | 1 |
| Bennett, DJ | 1 |
| Davoody, L | 1 |
| Quiton, RL | 1 |
| Lucas, JM | 1 |
| Ji, Y | 1 |
| Keller, A | 1 |
| Masri, R | 1 |
| Filli, L | 1 |
| Zörner, B | 1 |
| Weinmann, O | 1 |
| Schwab, ME | 1 |
| Al Dera, H | 1 |
| Habgood, MD | 1 |
| Furness, JB | 1 |
| Frigon, A | 1 |
| Johnson, MD | 1 |
| Heckman, CJ | 1 |
| Backo, AL | 1 |
| Clause, SL | 1 |
| Triller, DM | 1 |
| Gibbs, KA | 1 |
| Barbeau, H | 7 |
| Norman, KE | 2 |
| Carro-Juáreza, M | 1 |
| Rodríguez-Manzo, G | 1 |
| Côté, MP | 2 |
| Ménard, A | 1 |
| Gossard, JP | 2 |
| Denys, P | 5 |
| Even-Schneider, A | 1 |
| Rémy-Néris, O | 5 |
| Ben Smaïl, D | 1 |
| Chartier-Kastler, E | 4 |
| Bussel, B | 6 |
| Malinovsky, JM | 1 |
| Malinge, M | 1 |
| Lepage, JY | 1 |
| Pinaud, M | 1 |
| Parisod, E | 1 |
| Siddall, PJ | 4 |
| Viney, M | 1 |
| McClelland, JM | 1 |
| Cousins, MJ | 3 |
| Yeoh, M | 2 |
| Perren, F | 1 |
| Buchser, E | 1 |
| Chédel, D | 1 |
| Hirt, L | 1 |
| Maeder, P | 1 |
| Vingerhoets, F | 1 |
| Langlet, C | 1 |
| Leblond, H | 1 |
| Rossignol, S | 6 |
| Ma, W | 1 |
| Zhang, Y | 1 |
| Bantel, C | 1 |
| Eisenach, JC | 2 |
| Zou, Z | 1 |
| Shi, XY | 1 |
| Lü, Y | 1 |
| Xu, ZD | 1 |
| Shi, D | 1 |
| Wang, L | 1 |
| Liu, G | 1 |
| Taricco, M | 2 |
| Pagliacci, MC | 1 |
| Telaro, E | 2 |
| Adone, R | 2 |
| Martin, TJ | 1 |
| Kim, SA | 1 |
| Bevacqua, BK | 1 |
| Fattouh, M | 1 |
| Backonja, M | 1 |
| Schneider, AE | 1 |
| Ben-Smail, D | 1 |
| Ruffion, A | 1 |
| Kamen, L | 1 |
| Henney, HR | 1 |
| Runyan, JD | 1 |
| Naftchi, NE | 1 |
| Hall, PA | 1 |
| Young, JV | 1 |
| Tremblay, LE | 1 |
| Bedard, PJ | 1 |
| Bastings, E | 1 |
| Rapisarda, G | 1 |
| Pepin, JL | 1 |
| Delwaide, PJ | 1 |
| Gray, M | 1 |
| Rutkowski, S | 1 |
| Nance, PW | 4 |
| Bugaresti, J | 1 |
| Shellenberger, K | 1 |
| Sheremata, W | 1 |
| Martinez-Arizala, A | 1 |
| Rosenblum, D | 1 |
| Chau, C | 3 |
| Middleton, JW | 1 |
| Walker, S | 2 |
| Molloy, AR | 2 |
| Rutkowski, SB | 2 |
| Hao, JX | 1 |
| Yu, W | 1 |
| Xu, XJ | 1 |
| Wiesenfeld-Hallin, Z | 1 |
| Wickelgren, I | 1 |
| Pépin, A | 1 |
| Azouvi, P | 2 |
| Brenner, R | 1 |
| Hyman, N | 1 |
| Knobler, R | 1 |
| O'Brien, M | 1 |
| Stephan, T | 1 |
| Giroux, N | 3 |
| Brustein, E | 2 |
| Reader, TA | 3 |
| Daniel, O | 1 |
| Boiteau, F | 1 |
| Roche, WJ | 1 |
| Nwofia, C | 1 |
| Gittler, M | 1 |
| Patel, R | 1 |
| Yarkony, G | 1 |
| Yakovleff, A | 1 |
| Richard, F | 1 |
| Pagliacci, C | 1 |
| Marcoux, J | 2 |
| Mather, LE | 1 |
| Elovic, E | 1 |
| Advokat, C | 1 |
| Honda, M | 1 |
| Sekiguchi, Y | 1 |
| Sato, N | 1 |
| Ono, H | 1 |
| Glynn, CJ | 2 |
| Jamous, MA | 2 |
| Teddy, PJ | 2 |
| Weingarden, SI | 1 |
| Belen, JG | 1 |
| Edgerton, VR | 1 |
| Roy, RR | 1 |
| Hodgson, JA | 1 |
| Prober, RJ | 1 |
| de Guzman, CP | 1 |
| de Leon, R | 1 |
| Senard, JM | 1 |
| Arias, A | 1 |
| Berlan, M | 1 |
| Tran, MA | 1 |
| Rascol, A | 1 |
| Montastruc, JL | 1 |
| Stewart, JE | 2 |
| Gauthier, S | 1 |
| Herman, RM | 1 |
| Wainberg, MC | 1 |
| Fung, J | 1 |
| Shears, AH | 2 |
| Nance, DM | 2 |
| Mathias, CJ | 1 |
| Luckitt, J | 1 |
| Desai, P | 1 |
| Baker, H | 1 |
| el Masri, W | 1 |
| Frankel, HL | 1 |
| Farcot, JM | 1 |
| Mercky, F | 1 |
| Grasser, C | 1 |
| Moore, RA | 1 |
| Lloyd, JW | 1 |
| Donovan, WH | 1 |
| Carter, RE | 1 |
| Rossi, CD | 1 |
| Wilkerson, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of EXOPULSE Mollii Suit on Spasticity and Muscular Oxygenation in Patients With Multiple Sclerosis.[NCT05912595] | 36 participants (Anticipated) | Interventional | 2023-05-18 | Recruiting | |||
| Dexmedetomidine Comme Adjuvant à la rachianesthésie Lors de césariennes électives : Une étude Pilote[NCT05099055] | Phase 3 | 42 participants (Actual) | Interventional | 2022-03-15 | Completed | ||
| Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury[NCT03602014] | Phase 4 | 22 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for clonidine and Spinal Cord Injuries
| Article | Year |
|---|---|
Update on tizanidine for muscle spasticity and emerging indications.
Topics: Adrenergic alpha-2 Receptor Agonists; Clonidine; Dose-Response Relationship, Drug; Humans; Low Back | 2008 |
The effect of noradrenergic drugs on the recovery of walking after spinal cord injury.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Electromyography; Humans; Motor Activity; Norepinephr | 2003 |
[Intrathecal therapy for bladder hyperreflexia].
Topics: Adrenergic alpha-Agonists; Baclofen; Clonidine; Female; Humans; Injections, Spinal; Male; Muscle Rel | 2003 |
Pharmacological interventions for spasticity following spinal cord injury: results of a Cochrane systematic review.
Topics: Baclofen; Clonidine; Dantrolene; Humans; Muscle Relaxants, Central; Muscle Spasticity; Randomized Co | 2006 |
A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury.
Topics: Brain Injuries; Clonidine; Disease Progression; Drug Interactions; Female; Humans; Middle Aged; Mult | 2008 |
[Current pharmacological approach to the treatment of locomotion disorders due to spinal lesions].
Topics: Clonidine; Cyproheptadine; Humans; Locomotion; Spinal Cord Diseases; Spinal Cord Injuries | 1995 |
An approach to switching patients from baclofen to tizanidine.
Topics: Baclofen; Clinical Competence; Clonidine; Humans; Multiple Sclerosis; Muscle Relaxants, Central; Mus | 1998 |
Pharmacological interventions for spasticity following spinal cord injury.
Topics: Baclofen; Clonidine; Dantrolene; Humans; Muscle Relaxants, Central; Parasympatholytics; Spasm; Spina | 2000 |
Intrathecal clonidine for controlling spastic hypertonia.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Humans; Injections, Spinal; Muscle Spasticity; Reflex | 2001 |
Principles of pharmaceutical management of spastic hypertonia.
Topics: Anti-Dyskinesia Agents; Baclofen; Benzodiazepines; Botulinum Toxins; Brain Injuries; Clonidine; Dant | 2001 |
16 trials available for clonidine and Spinal Cord Injuries
| Article | Year |
|---|---|
Effect of antispastic drugs on motor reflexes and voluntary muscle contraction in incomplete spinal cord injury.
Topics: Adult; Baclofen; Clonidine; Cross-Over Studies; Double-Blind Method; Electromyography; Humans; Isome | 2014 |
Interventions to Reduce Spasticity and Improve Function in People With Chronic Incomplete Spinal Cord Injury: Distinctions Revealed by Different Analytical Methods.
Topics: Analysis of Variance; Cervical Vertebrae; Chronic Disease; Clonidine; Data Interpretation, Statistic | 2015 |
Variability in responsiveness to interventions in people with spinal cord injury: Do some respond better than others?
Topics: Ankle Joint; Clonidine; Humans; Muscle Relaxants, Central; Muscle Spasticity; Spinal Cord Injuries; | 2014 |
Classifying and predicting endurance outcomes of α2-adrenergic agonist intervention in spinal cord injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Clonidine; Humans; Physical Endurance; Recovery of Function; S | 2014 |
Sedation caused by clonidine in patients with spinal cord injury.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Analgesics; Analysis of Variance; Clonidine; Conscious Sedat | 2003 |
A comparison of clonidine, cyproheptadine and baclofen in spastic spinal cord injured patients.
Topics: Baclofen; Clonidine; Cyproheptadine; Dose-Response Relationship, Drug; Drug Administration Schedule; | 1994 |
Efficacy and safety of tizanidine in the treatment of spasticity in patients with spinal cord injury. North American Tizanidine Study Group.
Topics: Activities of Daily Living; Administration, Oral; Adolescent; Adult; Aged; Clonidine; Female; Humans | 1994 |
Effects of drugs on walking after spinal cord injury.
Topics: Adrenergic alpha-Agonists; Adult; Baclofen; Clonidine; Cyproheptadine; Electromyography; Exercise Te | 1998 |
Intrathecal clonidine for refractory detrusor hyperreflexia in spinal cord injured patients: a preliminary report.
Topics: Adrenergic alpha-Agonists; Clonidine; Dose-Response Relationship, Drug; Female; Humans; Injections, | 1998 |
Intrathecal catheter with subcutaneous port for clonidine test bolus injection. A new route and type of treatment for detrusor hyperreflexia in spinal cord-injured patients.
Topics: Adult; Catheters, Indwelling; Clonidine; Feasibility Studies; Female; Humans; Male; Middle Aged; Mus | 2000 |
The efficacy of intrathecal morphine and clonidine in the treatment of pain after spinal cord injury.
Topics: Adult; Aged; Analgesics, Opioid; Blood Pressure; Clonidine; Double-Blind Method; Female; Heart Rate; | 2000 |
Clonidine transdermal system for treatment of spasticity in spinal cord injury.
Topics: Administration, Cutaneous; Adult; Aged; Clonidine; Humans; Middle Aged; Muscle Spasticity; Spinal Co | 1992 |
Modulation of locomotor patterns and spasticity with clonidine in spinal cord injured patients.
Topics: Adult; Clonidine; Double-Blind Method; Electromyography; Humans; Locomotion; Male; Middle Aged; Musc | 1991 |
The combined effects of clonidine and cyproheptadine with interactive training on the modulation of locomotion in spinal cord injured subjects.
Topics: Adult; Biomechanical Phenomena; Clonidine; Combined Modality Therapy; Cyproheptadine; Double-Blind M | 1990 |
Reflex changes induced by clonidine in spinal cord injured patients.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; H-Reflex; Humans; Muscle Spasticity; Reflex, Monosynapt | 1989 |
Role of spinal noradrenergic system in transmission of pain in patients with spinal cord injury.
Topics: Adult; Aged; Central Nervous System; Clonidine; Female; Humans; Injections, Epidural; Male; Middle A | 1986 |
54 other studies available for clonidine and Spinal Cord Injuries
| Article | Year |
|---|---|
Noradrenergic Components of Locomotor Recovery Induced by Intraspinal Grafting of the Embryonic Brainstem in Adult Paraplegic Rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brain Stem; | 2020 |
Therapeutic effects of anti-spastic medication on neuromuscular abnormalities in SCI: a system identification approach.
Topics: Algorithms; Ankle; Ankle Joint; Anticonvulsants; Clonidine; Electromyography; Exercise Therapy; Huma | 2013 |
Facilitatory effects of anti-spastic medication on robotic locomotor training in people with chronic incomplete spinal cord injury.
Topics: Adult; Aged; Biomechanical Phenomena; Clonidine; Female; Gait; Humans; Isometric Contraction; Learni | 2015 |
Comparison between the therapeutic effects of robotic-assisted locomotor training and an anti-spastic medication on spasticity.
Topics: Ankle Joint; Clonidine; Electromyography; Humans; Motor Activity; Muscle Relaxants, Central; Muscle | 2015 |
Tail pinching-induced hindlimb movements are suppressed by clonidine in spinal cord injured mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics; Animals; Behavior, Animal; Clonidine; Dose-Respo | 2008 |
Quantification of the effects of an alpha-2 adrenergic agonist on reflex properties in spinal cord injury using a system identification technique.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Ankle Joint; Clonidine; Elas | 2010 |
Sympathetic vasoconstriction is potentiated in arteries caudal but not rostral to a spinal cord transection in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Data Interpre | 2010 |
Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Chromones; Clonidine; Excitatory Postsynaptic | 2011 |
Conditioned place preference reveals tonic pain in an animal model of central pain.
Topics: Analgesics; Animals; Buprenorphine; Clonidine; Conditioning, Operant; Disease Models, Animal; Electr | 2011 |
Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Brown-Sequard Syndrome; Clonidine; Dis | 2011 |
Prominent contribution of L-type Ca2+ channels to cutaneous neurovascular transmission that is revealed after spinal cord injury augments vasoconstriction.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
Differential modulation of crossed and uncrossed reflex pathways by clonidine in adult cats following complete spinal cord injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cats; Clonidine; Electric Stimulation; Electromyograp | 2012 |
Clonidine-induced hypertension in a patient with a spinal lesion.
Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Chronic Disease; Clonidine; Fructose; Humans; Hype | 2002 |
Yohimbine reverses the exhaustion of the coital reflex in spinal male rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Copulation; Ejaculation | 2003 |
Spinal cats on the treadmill: changes in load pathways.
Topics: Adrenergic alpha-Agonists; Afferent Pathways; Animals; Cats; Clonidine; Excitatory Postsynaptic Pote | 2003 |
Allodynia after acute intrathecal morphine administration in a patient with neuropathic pain after spinal cord injury.
Topics: Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Anesthetics, Local; Clonidine; Humans; Injectio | 2003 |
Tail arteries from chronically spinalized rats have potentiated responses to nerve stimulation in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Autonomic Dysreflexia; C | 2004 |
Spinal cord lesion after long-term intrathecal clonidine and bupivacaine treatment for the management of intractable pain.
Topics: Analgesia, Epidural; Analgesics; Bupivacaine; Clonidine; Humans; Infusion Pumps, Implantable; Longit | 2004 |
Chronic decentralization potentiates neurovascular transmission in the isolated rat tail artery, mimicking the effects of spinal transection.
Topics: Animals; Arteries; Clonidine; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Lumbar | 2004 |
Step training-dependent plasticity in spinal cutaneous pathways.
Topics: Adrenergic alpha-Agonists; Animals; Cats; Clonidine; Evoked Potentials; Exercise Therapy; Feedback, | 2004 |
Mid-lumbar segments are needed for the expression of locomotion in chronic spinal cats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cats; Clonidine; Deceleration; Ele | 2005 |
Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Cell Count; Cell Size; Clonidine; Functional Laterality | 2005 |
[Role of alpha-adrenergic receptors in vascular hyperreactivity in rats with high level spinal injury].
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Abdominal; Clonidine; Disease Models, Animal; Female; Mal | 2006 |
Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation.
Topics: Analgesics; Animals; Clonidine; Hyperalgesia; Injections, Spinal; Male; Neuralgia; Pain Measurement; | 2006 |
Depression, night terrors, and insomnia associated with long-term intrathecal clonidine therapy.
Topics: Aged; Analgesics; Aortic Aneurysm, Thoracic; Catheterization; Clonidine; Humans; Male; Neuritis; Pai | 2007 |
[Pharmacological treatment of neurogenic detrusor hyperactivity: intrathecal drugs].
Topics: Baclofen; Clonidine; Erectile Dysfunction; Humans; Injections, Spinal; Male; Spinal Cord Injuries; U | 2007 |
Effects of spinal alpha(2)-adrenoceptor and I(1)-imidazoline receptor activation on hindlimb movement induction in spinal cord-injured mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2008 |
Functional restoration of the traumatically injured spinal cord in cats by clonidine.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Cats; Cell Membrane; Clonidine; Humans; Muscle Sp | 1982 |
Autonomic hyperreflexia in spinal cord injured patients: trigger mechanism--dressing changes of pressure sores.
Topics: Adult; Autonomic Nervous System; Bandages; Clonidine; Humans; Male; Pressure Ulcer; Reflex, Abnormal | 1983 |
Action of 5-hydroxytryptamine, substance P, thyrotropin releasing hormone and clonidine on spinal neuron excitability.
Topics: 5-Hydroxytryptophan; Animals; Clonidine; Electromyography; Female; Motor Neurons; Muscle Spasticity; | 1995 |
Intrathecal morphine and clonidine in the management of spinal cord injury pain: a case report.
Topics: Adult; Chronic Disease; Clonidine; Drug Therapy, Combination; Humans; Infusion Pumps; Injections, Sp | 1994 |
Clonidine-induced bradycardia in patients with spinal cord injury.
Topics: Adult; Bradycardia; Clonidine; Humans; Male; Muscle Spasticity; Spinal Cord Injuries | 1993 |
Noradrenergic agonists and locomotor training affect locomotor recovery after cord transection in adult cats.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Cats; Clonidine; Combined Modality Therapy; Locomotion; M | 1993 |
Intrathecal clonidine and baclofen in the management of spasticity and neuropathic pain following spinal cord injury: a case study.
Topics: Adult; Baclofen; Clonidine; Female; Humans; Infusion Pumps, Implantable; Injections, Spinal; Muscle | 1996 |
A new drug to treat spasticity?
Topics: Clonidine; Drug Approval; Humans; Multiple Sclerosis; Muscle Relaxants, Central; Spinal Cord Injurie | 1996 |
Effects of intrathecal vs. systemic clonidine in treating chronic allodynia-like response in spinally injured rats.
Topics: Animals; Blood Pressure; Clonidine; Female; Injections, Intraperitoneal; Injections, Spinal; Ischemi | 1996 |
Teaching the spinal cord to walk.
Topics: Animals; Cats; Clonidine; Electrophysiology; Hindlimb; Humans; Leg; Motor Neurons; Muscle, Skeletal; | 1998 |
Spasticity: current and future management. Royal College of Physicians, November 13, 1997.
Topics: Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug; Gait; Humans; Muscle Spastici | 1998 |
Differential effects of the noradrenergic agonist clonidine on the locomotion of intact, partially and completely spinalized adult cats.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cats; Clonidine | 1998 |
Effects of intrathecal clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Electromyography; Female; Gait; Humans; Injection | 1999 |
Catecholamine-induced hypertension in lumbosacral paraplegia: five case reports.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Blood Pressure; Catecholamines; Clonidine; Humans; Hyp | 2000 |
Initiating or blocking locomotion in spinal cats by applying noradrenergic drugs to restricted lumbar spinal segments.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cats; Clonidine; Decerebrate State | 2000 |
Pharmacological aids to locomotor training after spinal injury in the cat.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Cats; Clonidine; Excitatory Amin | 2001 |
Comparison of the effect of intrathecal administration of clonidine and yohimbine on the locomotion of intact and spinal cats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cats; Clonidine; Electric Stimulat | 2001 |
Spinal transection increases the potency of clonidine on the tail-flick and hindlimb flexion reflexes.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; | 2002 |
Involvement of imidazoline receptors in the centrally acting muscle-relaxant effects of tizanidine.
Topics: Animals; Cervical Vertebrae; Clonidine; Imidazoline Receptors; Male; Muscle Relaxants, Central; Rats | 2002 |
Cerebrospinal fluid kinetics of epidural clonidine in man.
Topics: Adult; Aged; Clonidine; Female; Half-Life; Humans; Injections, Epidural; Male; Middle Aged; Pain; Ra | 1992 |
Potential of adult mammalian lumbosacral spinal cord to execute and acquire improved locomotion in the absence of supraspinal input.
Topics: Animals; Cats; Clonidine; Electromyography; Female; Locomotion; Motor Activity; Muscles; Spinal Cord | 1992 |
Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report.
Topics: Blood Pressure; Chronic Disease; Clonidine; Efferent Pathways; Humans; Hypotension, Orthostatic; Mal | 1991 |
Clonidine inhibits vesico-sphincter reflexes in patients with chronic spinal lesions.
Topics: Adult; Blood Pressure; Clonidine; Electromyography; Female; Humans; Muscle Contraction; Muscle Spast | 1991 |
Pharmacodynamics and pharmacokinetics of the oral antispastic agent tizanidine in patients with spinal cord injury.
Topics: Administration, Oral; Adult; Blood Pressure; Clonidine; Drug Evaluation; Heart Rate; Humans; Male; M | 1989 |
[Thoracolumbar or sacral epidural administration of clonidine in deafferentation pain: possibilities, limits and long-term follow-up].
Topics: Chronic Disease; Clonidine; Follow-Up Studies; Humans; Injections, Epidural; Pain; Spinal Cord Injur | 1989 |
Clonidine in spinal cord injury.
Topics: Adult; Clonidine; Female; Humans; Male; Middle Aged; Muscle Spasticity; Receptors, Adrenergic, alpha | 1985 |
Clonidine effect on spasticity: a clinical trial.
Topics: Adolescent; Adult; Aged; Clonidine; Female; Humans; Male; Middle Aged; Muscle Spasticity; Paraplegia | 1988 |