clonidine has been researched along with Sleep Wake Disorders in 30 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ten patients with idiopathic restless leg syndrome (RLS) were asked to rate their symptoms at baseline during 2 weeks of placebo and 2 weeks of clonidine treatment by using a four-point scale." | 9.08 | Randomized, Double-Blind, Placebo-Controlled Study of Clonidine in Restless Legs Syndrome. ( Chokroverty, S; Coleman, RG; Grasing, K; Hening, WA; Wagner, ML; Walters, AS, 1996) |
| "Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD." | 6.73 | Use of clonidine in children with autism spectrum disorders. ( Gordon, E; Kang, N; Ming, X; Wagner, GC, 2008) |
| "Ten patients with idiopathic restless leg syndrome (RLS) were asked to rate their symptoms at baseline during 2 weeks of placebo and 2 weeks of clonidine treatment by using a four-point scale." | 5.08 | Randomized, Double-Blind, Placebo-Controlled Study of Clonidine in Restless Legs Syndrome. ( Chokroverty, S; Coleman, RG; Grasing, K; Hening, WA; Wagner, ML; Walters, AS, 1996) |
| "This paper reports on the use of clonidine for the treatment of severe sleep problems associated with behavioural difficulties in children with neurodevelopmental disabilities." | 3.73 | The use of clonidine for severe and intractable sleep problems in children with neurodevelopmental disorders--a case series. ( Ingrassia, A; Turk, J, 2005) |
| " With the exception of one subject, all pre-eclamptics were taking clonidine (a known suppressant of rapid eye movement-REM-sleep) for control of their hypertension." | 3.70 | Pre-eclampsia is associated with marked alterations in sleep architecture. ( Blyton, CM; Edwards, N; Kesby, GJ; Sullivan, CE; Wilcox, I, 2000) |
| " To reduce muscle tension, 34 patients of the main group received tizanidine with the modified release of active substance (sirdalud MR) in dosage one capsule (6 mg) per day." | 2.75 | [The use of sirdalud MR in patients with multiple sclerosis]. ( Batysheva, TT; Boĭko, AN; Kamchatnov, PR; Petrov, SV; Popova, NF; Zaĭtsev, KA, 2010) |
| "Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD." | 2.73 | Use of clonidine in children with autism spectrum disorders. ( Gordon, E; Kang, N; Ming, X; Wagner, GC, 2008) |
| "Tizanidine is a centrally acting alpha-2 adrenoreceptor agonist widely used in the treatment of spasticity in patients with cerebral or spinal injury, and it is causing drawsiness in some of them." | 2.71 | [Effects of tizanidine for refractory sleep disturbance in disabled children with spastic quadriplegia]. ( Cho, K; Fujieda, K; Fukuda, I; Miyamoto, A; Oka, R; Tanaka, H, 2004) |
| " While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs." | 2.49 | Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. ( Banaschewski, T; Buitelaar, J; Coghill, D; Cortese, S; Danckaerts, M; Dittmann, RW; Graham, J; Holtmann, M; Sergeant, J; Taylor, E, 2013) |
| "This article reviews common sleep disorders in children and pharmacologic options for them." | 2.48 | Pediatric sleep pharmacology. ( Pelayo, R; Yuen, K, 2012) |
| "Posttraumatic stress disorder (PTSD) symptoms of hyperarousal are mediated through sympathetic nervous system hyperactivity." | 1.62 | Low-dose clonidine in veterans with Posttraumatic stress disorder. ( Burek, GA; Heslin, K; Larsen, SE; Liewen, AK; Waite, MR; Yaqub, TM, 2021) |
| "A total of 578 women with breast cancer were managed at the Menopausal Symptoms After Cancer Clinic between January 2003 and December 2008." | 1.36 | The multidisciplinary management of menopausal symptoms after breast cancer: a unique model of care. ( Doherty, DA; Emery, LI; Gregson, J; Hickey, M; Saunders, CM, 2010) |
| "(3,4) We report adverse effects of topical apraclonidine when used in the diagnosis of Horner syndrome in infants." | 1.34 | Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants. ( Lim, MK; Satterfield, D; Watts, P, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (26.67) | 18.7374 |
| 1990's | 4 (13.33) | 18.2507 |
| 2000's | 10 (33.33) | 29.6817 |
| 2010's | 6 (20.00) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Pereira, JA | 1 |
| Ravichandran, CT | 1 |
| Mullett, J | 1 |
| McDougle, CJ | 1 |
| Keary, CJ | 1 |
| Burek, GA | 1 |
| Waite, MR | 1 |
| Heslin, K | 1 |
| Liewen, AK | 1 |
| Yaqub, TM | 1 |
| Larsen, SE | 1 |
| Nguyen, M | 1 |
| Tharani, S | 1 |
| Rahmani, M | 1 |
| Shapiro, M | 1 |
| Amos, LB | 1 |
| Grekowicz, ML | 1 |
| Kuhn, EM | 1 |
| Olstad, JD | 1 |
| Collins, MM | 1 |
| Norins, NA | 1 |
| D'Andrea, LA | 1 |
| Ziegenhorn, AA | 1 |
| Roepke, S | 1 |
| Schommer, NC | 1 |
| Merkl, A | 1 |
| Danker-Hopfe, H | 1 |
| Perschel, FH | 1 |
| Heuser, I | 1 |
| Anghelescu, IG | 1 |
| Lammers, CH | 1 |
| Hickey, M | 1 |
| Emery, LI | 1 |
| Gregson, J | 1 |
| Doherty, DA | 1 |
| Saunders, CM | 1 |
| Batysheva, TT | 1 |
| Popova, NF | 1 |
| Petrov, SV | 1 |
| Kamchatnov, PR | 1 |
| Zaĭtsev, KA | 1 |
| Boĭko, AN | 1 |
| Pelayo, R | 1 |
| Yuen, K | 1 |
| Cortese, S | 2 |
| Holtmann, M | 1 |
| Banaschewski, T | 1 |
| Buitelaar, J | 1 |
| Coghill, D | 1 |
| Danckaerts, M | 1 |
| Dittmann, RW | 1 |
| Graham, J | 1 |
| Taylor, E | 1 |
| Sergeant, J | 1 |
| Beswick, T | 1 |
| Best, D | 1 |
| Rees, S | 1 |
| Bearn, J | 1 |
| Gossop, M | 1 |
| Strang, J | 1 |
| Tanaka, H | 1 |
| Fukuda, I | 1 |
| Miyamoto, A | 1 |
| Oka, R | 1 |
| Cho, K | 1 |
| Fujieda, K | 1 |
| Ingrassia, A | 1 |
| Turk, J | 1 |
| Lecendreux, M | 1 |
| Mouren, MC | 1 |
| Konofal, E | 1 |
| Schnoes, CJ | 1 |
| Kuhn, BR | 1 |
| Workman, EF | 1 |
| Ellis, CR | 1 |
| Kelsay, K | 1 |
| Watts, P | 1 |
| Satterfield, D | 1 |
| Lim, MK | 1 |
| Ming, X | 1 |
| Gordon, E | 1 |
| Kang, N | 1 |
| Wagner, GC | 1 |
| Sills, M | 1 |
| Congdon, P | 1 |
| Forsythe, I | 1 |
| Campbell, M | 1 |
| Cueva, JE | 1 |
| Kinzie, JD | 1 |
| Sack, RL | 1 |
| Riley, CM | 1 |
| Wagner, ML | 1 |
| Walters, AS | 1 |
| Coleman, RG | 1 |
| Hening, WA | 1 |
| Grasing, K | 1 |
| Chokroverty, S | 1 |
| Prince, JB | 1 |
| Wilens, TE | 1 |
| Biederman, J | 1 |
| Spencer, TJ | 1 |
| Wozniak, JR | 1 |
| Edwards, N | 1 |
| Blyton, CM | 1 |
| Kesby, GJ | 1 |
| Wilcox, I | 1 |
| Sullivan, CE | 1 |
| Henning, M | 1 |
| Ringwald, E | 1 |
| Campean, SJ | 1 |
| Gerstenbrand, F | 1 |
| Lorincz, A | 1 |
| Lörincz, P | 1 |
| Ludin, HP | 1 |
| Antonello, A | 1 |
| Campanini, M | 1 |
| Glorioso, S | 1 |
| Borsatti, A | 1 |
| Todesco, S | 1 |
| Mirmiran, M | 1 |
| Feenstra, MG | 1 |
| Dijcks, FA | 1 |
| Bos, NP | 1 |
| Van Haaren, F | 1 |
| Koella, WP | 1 |
| Huisjes, HJ | 1 |
| Hadders-Algra, M | 1 |
| Touwen, BC | 1 |
| Picchione, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.[NCT06069323] | 80 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for clonidine and Sleep Wake Disorders
| Article | Year |
|---|---|
A review of the use of clonidine as a sleep aid in the child and adolescent population.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Attention Deficit Disorder with Hyperactivity; Chi | 2014 |
Pediatric sleep pharmacology.
Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Child; Child, Preschool; Clonidine; Contraindicat | 2012 |
Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents.
Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Blood Pressure | 2013 |
Management of sleep disturbance associated with atopic dermatitis.
Topics: Algorithms; Clonidine; Dermatitis, Atopic; Doxepin; Histamine H1 Antagonists; Humans; Hypnotics and | 2006 |
Psychopharmacology in child and adolescent psychiatry: a review of the past seven years. Part II.
Topics: Adolescent; Alprazolam; Anticonvulsants; Antipsychotic Agents; Anxiety, Separation; Bipolar Disorder | 1995 |
Functional deprivation of noradrenaline neurotransmission: effects of clonidine on brain development.
Topics: Animals; Brain; Child, Preschool; Clonidine; Fetus; Humans; Mental Disorders; Neurotoxins; Norepinep | 1988 |
CNS-related (side-)effects of beta-blockers with special reference to mechanisms of action.
Topics: Adrenergic beta-Antagonists; Amphetamine; Animals; Anxiety; Blood-Brain Barrier; Central Nervous Sys | 1985 |
8 trials available for clonidine and Sleep Wake Disorders
| Article | Year |
|---|---|
Clonidine improves hyperarousal in borderline personality disorder with or without comorbid posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial.
Topics: Adrenergic alpha-Agonists; Adult; Arousal; Borderline Personality Disorder; Clonidine; Cross-Over St | 2009 |
[The use of sirdalud MR in patients with multiple sclerosis].
Topics: Adult; Clonidine; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Relaxants, Central; Muscle W | 2010 |
[Effects of tizanidine for refractory sleep disturbance in disabled children with spastic quadriplegia].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Child; Child, Preschool; Clonidine; Disabled Children; | 2004 |
Use of clonidine in children with autism spectrum disorders.
Topics: Adolescent; Adrenergic alpha-Agonists; Aggression; Attention Deficit Disorder with Hyperactivity; At | 2008 |
Clonidine and childhood migraine: a pilot and double-blind study.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Eruptions; F | 1982 |
Randomized, Double-Blind, Placebo-Controlled Study of Clonidine in Restless Legs Syndrome.
Topics: Adrenergic Agonists; Adult; Age of Onset; Clonidine; Double-Blind Method; Electroencephalography; Fe | 1996 |
[Clinical experiences with a new muscle relaxant (DS 103-282 Sandoz) (author's transl)].
Topics: Adult; Clinical Trials as Topic; Clonidine; Drug Evaluation; Drug Tolerance; Female; Humans; Male; M | 1977 |
[Long-term ambulatory treatment of arterial hypertension with clonidine].
Topics: Adult; Aged; Ambulatory Care; Clinical Trials as Topic; Clonidine; Drug Evaluation; Erectile Dysfunc | 1974 |
15 other studies available for clonidine and Sleep Wake Disorders
| Article | Year |
|---|---|
Characterization of sleep habits and medication outcomes for sleep disturbance in children and adults with Angelman syndrome.
Topics: Adolescent; Adult; Angelman Syndrome; Child; Child, Preschool; Clonidine; Female; Humans; Male; Mela | 2020 |
Low-dose clonidine in veterans with Posttraumatic stress disorder.
Topics: Clonidine; Humans; Retrospective Studies; Sleep Wake Disorders; Stress Disorders, Post-Traumatic; Tr | 2021 |
Treatment of pediatric restless legs syndrome.
Topics: Adolescent; Amines; Analgesics; Anticonvulsants; Antioxidants; Benzothiazoles; Child; Child, Prescho | 2014 |
The multidisciplinary management of menopausal symptoms after breast cancer: a unique model of care.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care Facilities; Amines; Anti-Anxiety Agents; Breast Neop | 2010 |
Major disruptions of sleep during treatment of the opiate withdrawal syndrome: differences between methadone and lofexidine detoxification treatments.
Topics: Clonidine; Humans; Methadone; Narcotic Antagonists; Narcotics; Sleep Wake Disorders; Substance Withd | 2003 |
The use of clonidine for severe and intractable sleep problems in children with neurodevelopmental disorders--a case series.
Topics: Adolescent; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Brain; Child; Cloni | 2005 |
ADHD and insomnia.
Topics: Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimula | 2006 |
Pediatric prescribing practices for clonidine and other pharmacologic agents for children with sleep disturbance.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Behavior Therapy; Child; Child, Preschool; Clonidine; | 2006 |
Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants.
Topics: Adrenergic alpha-Agonists; Bradycardia; Clonidine; Emergency Treatment; Female; Horner Syndrome; Hum | 2007 |
The polysomnographic effects of clonidine on sleep disorders in posttraumatic stress disorder: a pilot study with Cambodian patients.
Topics: Adult; Cambodia; Clonidine; Combined Modality Therapy; Comorbidity; Dreams; Female; Humans; Middle A | 1994 |
Clonidine for sleep disturbances associated with attention-deficit hyperactivity disorder: a systematic chart review of 62 cases.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Clonidine; Dose- | 1996 |
Pre-eclampsia is associated with marked alterations in sleep architecture.
Topics: Adult; Antihypertensive Agents; Clonidine; Electroencephalography; Electrooculography; Female; Human | 2000 |
Adverse reactions to antihypertensive drug therapy: central nervous system.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Brain; Clonidine; Depression; Humans; Hypnotic | 1979 |
[Clinical effects of a clonidine-chlorthalidone combination in the treatment of arterial hypertension].
Topics: Adult; Chlorthalidone; Clonidine; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypert | 1976 |
Is clonidine a behavioural teratogen in the human?
Topics: Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Clonidine; Dose-Response Rel | 1986 |