Page last updated: 2024-10-25

clonidine and Sleep Apnea Syndromes

clonidine has been researched along with Sleep Apnea Syndromes in 2 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Sleep Apnea Syndromes: Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Moss, JR	1
Cofer, S	1
Hersey, S	1
Goudy, S	1
Werkhaven, J	1
Swanson, E	1
Mantle, C	1
Stowell, N	1
Byrne, D	1
Wang, L	1
Labadie, R	1
Issa, FG	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Pediatric Tonsillectomy Pain Reduction Study, a Randomized, Placebo Controlled, Double-Blind Clinical Trial Using Clonidine and Local Anesthetics[NCT00678379]			Phase 3	120 participants (Actual)	Interventional	2008-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Median Number of Pain Medication Doses

The median number of intravenous fentanyl doses administered in the PACU due to pain (NCT00678379)
Timeframe: in recovery room

Intervention	number of doses (Median)
Normal Saline	3.0
Lidocaine (1%) + Bupivacaine 0.5%	3
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	3

Total Number of Post-operative Doses of Analgesics.

The total number of intravenous fentanyl doses given PACU which will be compared between the three randomized groups (arms) (NCT00678379)
Timeframe: Post-operative thru day 7

Intervention	number of doses (Median)
Normal Saline	12
Lidocaine (1%) + Bupivacaine 0.5%	12
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	14

Total Time Until Discharge From Hospital.

(NCT00678379)
Timeframe: Day of Surgery

Intervention	minutes (Median)
Normal Saline	122
Lidocaine (1%) + Bupivacaine 0.5%	111
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	120

Mean Visual Analog Scale Pain Number.

Visual analog pain scale range is 0-10 with 0=no pain and 10 = worst pain ever (NCT00678379)
Timeframe: in recovery room; post-operative days 1,3,5 & 7

Intervention	pain score (Mean)
	In recovery room	day 1	day 3	day 5	day 7
Lidocaine (1%) + Bupivacaine 0.5%	3	4	2.5	2	2
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	3	5	3	3	2
Normal Saline	3	3	3	3	2.5

Number and Percent of Participants Able to Tolerate a Regular Diet

The number and percent of patients whose post-operative diet has to a regular diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	4	8	18	26
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	1	12	14	22
Normal Saline	7	18	21	24

Number and Percent of Participants Able to Tolerate Only a Soft Diet

The number and percent of patients whose post-operative diet has only advanced to a soft diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	22	26	17	10
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	26	18	18	14
Normal Saline	26	18	13	13

Number and Percent of Participants Able to Tolerate Only Liquids

The number and percent of patients whose post-operative diet has advanced to liquids only on post-op days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	33	13	10	11
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	30	23	19	10
Normal Saline	16	8	13	6

Trials

2 trials available for clonidine and Sleep Apnea Syndromes

Article	Year
Comparison of clonidine, local anesthetics, and placebo for pain reduction in pediatric tonsillectomy. Archives of otolaryngology--head & neck surgery, 2011, Volume: 137, Issue:6 Topics: Adenoids; Adolescent; Age Factors; Analgesics; Anesthetics, Local; Bupivacaine; Child; Child, Presch	2011
Effect of clonidine in obstructive sleep apnea. The American review of respiratory disease, 1992, Volume: 145, Issue:2 Pt 1 Topics: Adult; Clonidine; Electrocardiography; Electroencephalography; Electromyography; Humans; Male; Middl	1992