clonidine has been researched along with Respiration Disorders in 6 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Respiration Disorders: Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonidine poisoning usually causes depressed sensorium, hypotension, and bradycardia." | 4.76 | Clonidine overdose: report of six cases and review of the literature. ( Anderson, RJ; Crumpler, CP; Hart, GR; Lerman, MJ, 1981) |
| "(3,4) We report adverse effects of topical apraclonidine when used in the diagnosis of Horner syndrome in infants." | 1.34 | Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants. ( Lim, MK; Satterfield, D; Watts, P, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Valença, AM | 1 |
| Nardi, AE | 1 |
| Mezzasalma, MA | 1 |
| Nascimento, I | 1 |
| Lopes, FL | 1 |
| Zin, WA | 1 |
| Versiani, M | 1 |
| Watts, P | 1 |
| Satterfield, D | 1 |
| Lim, MK | 1 |
| Anderson, RJ | 1 |
| Hart, GR | 1 |
| Crumpler, CP | 1 |
| Lerman, MJ | 1 |
| O'Halloran, KD | 1 |
| Herman, JK | 1 |
| Bisgard, GE | 1 |
| Thomas, AJ | 1 |
| Erokwu, BO | 1 |
| Yamamoto, BK | 1 |
| Ernsberger, P | 1 |
| Bishara, O | 1 |
| Strohl, KP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
1 review available for clonidine and Respiration Disorders
| Article | Year |
|---|---|
Clonidine overdose: report of six cases and review of the literature.
Topics: Adolescent; Adult; Atropine; Bradycardia; Child, Preschool; Clonidine; Dopamine; Female; Humans; Hyp | 1981 |
5 other studies available for clonidine and Respiration Disorders
| Article | Year |
|---|---|
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Clonidine in respiratory panic disorder subtype.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Female; Humans; Panic Disorder; Respiration Disorders | 2004 |
Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants.
Topics: Adrenergic alpha-Agonists; Bradycardia; Clonidine; Emergency Treatment; Female; Horner Syndrome; Hum | 2007 |
Nonvagal tachypnea following alpha2-adrenoceptor stimulation in awake goats.
Topics: Adrenergic alpha-Agonists; Afferent Pathways; Animals; Biguanides; Clonidine; Feedback; Female; Goat | 1999 |
Alterations in respiratory behavior, brain neurochemistry and receptor density induced by pharmacologic suppression of sleep in the neonatal period.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Animals, Newborn; Animals, Suckling; Brain; Brain Chemist | 2000 |